Novel nutritional composition and application thereof

Abstract

The invention belongs to the technical field of nutritional supplements, and particularly relates to a novel nutritional composition and application thereof. Comprising creatine monohydrate and a Chinese wolfberry extract, and the weight ratio of the creatine monohydrate to the Chinese wolfberry extract is (0.5: 1)-(3: 1). Experiments find that after a human body takes the nutritional composition, the content of phosphocreatine PCr in muscles can be increased by 14%-19%, the 1-RM strength can be increased by 6.1%-8.5%, and it is indicated that the nutritional composition has the effect of improving the functional muscle strength and the phosphocreatine level. And the effect generated by the nutritional composition is far beyond the sum of the independent effects of all the components, so that the combination of the creatine monohydrate and the wolfberry extract has an unexpected and non-obvious synergistic effect in the aspects of improving the functional muscle strength and the creatine phosphate level.

Description

Technical Field

[0001] The present invention belongs to the technical field of nutritional supplements, and in particular relates to a novel nutritional composition and application thereof. Background Art

[0002] Nutritional supplements are widely used to improve health, well-being, and athletic performance. Two well-known supplements in this field are creatine monohydrate and goji berry (also known as goji berry or Lycium barbarum) extract.

[0003] Goji berry, a fruit highly revered in traditional medicine, is now gaining popularity as a health supplement. Goji berry extracts are rich in antioxidants, polysaccharides, vitamins (A and C), and other phytonutrients, which have been linked to a variety of health benefits, including improved immune function and antioxidant capacity. Human studies have shown that drinking goji berry juice can increase subjective energy, concentration, and even enhance athletic performance. However, on its own, goji berry is not generally considered a strong enhancer of muscle strength. Its performance benefits tend to be mild or auxiliary, typically attributed to improved vitality or recovery rather than a direct increase in muscle strength or phosphocreatine levels, as creatine does.

[0004] In contrast, creatine monohydrate is one of the most established and effective dietary supplements for improving muscle performance. Creatine is naturally stored in muscle as phosphocreatine (PCr), which helps regenerate ATP during high-intensity activity. Oral creatine supplementation has been shown to increase PCr levels within muscle, thereby increasing the energy required for brief, high-intensity exercise. A standard dose of creatine can increase muscle PCr by approximately 10% to 20% within a few weeks and improve one-repetition maximum (1-RM) strength by several percentage points. Creatine is known for its ability to achieve gains in muscle strength and size beyond those achieved through training alone.

[0005] Despite the widespread use of creatine and the growing interest in goji berries, both ingredients have been used independently in the health and sports nutrition fields. The prior art posits that these two ingredients have separate and distinct physiological benefits: creatine for anaerobic performance, and goji berries for antioxidant support and overall well-being. The prior art does not teach or suggest combining goji berry extract with creatine for performance enhancement. Therefore, addressing this gap, a nutritional supplement combining goji berry extract and creatine monohydrate was developed to enhance the effects of increasing muscle strength and creatine phosphate levels. Summary of the Invention

[0006] Based on this, the present application provides a novel nutritional composition to solve the technical gap in the prior art of combining wolfberry extract with creatine to enhance performance.

[0007] The technical solution of the present application to solve the above technical problems is as follows: A novel nutritional composition, comprising creatine monohydrate and wolfberry extract, wherein the weight ratio of the creatine monohydrate to the wolfberry extract is (0.5:1) to (3:1).

[0008] Preferably, in the novel nutritional composition, the weight ratio of the creatine monohydrate to the wolfberry extract is 2:1.

[0009] Preferably, in the novel nutritional composition, the wolfberry extract contains more than 40% polysaccharides.

[0010] Preferably, in the novel nutritional composition, the wolfberry extract contains 40% to 60% polysaccharides.

[0011] Application of the novel nutritional composition in a nutritional supplement.

[0012] Preferably, in the application, conventional excipients are added to the novel nutritional composition, and a clinically acceptable dosage form is prepared according to a conventional process.

[0013] Preferably, in the application, the novel nutritional composition is prepared into a capsule, wherein the capsule comprises the novel nutritional composition and excipients, and the excipients include fillers, disintegrants, lubricants, glidants, and sweeteners.

[0014] Preferably, in the application, the mass ratio of the novel nutritional composition to the excipients is (1 to 2):1.

[0015] Preferably, in the application, the fillers include any one of microcrystalline cellulose, hydroxypropyl cellulose, corn starch, pregelatinized starch, mannitol, sorbitol, etc.; the disintegrants include any one of croscarmellose sodium, low-substituted hydroxypropyl cellulose, cross-linked povidone, sodium carboxymethyl starch, etc.; the lubricants include any one of magnesium stearate, calcium stearate, potassium stearate, polyethylene glycol, sodium dodecyl sulfate, etc.; the glidants include any one of silicon dioxide, talc, corn starch, etc.; and the sweeteners include any one of sucrose, lactose, mannitol, sorbitol, aspartame, stevioside, etc.

[0016] A preparation method of the capsule as described above, comprising the following steps: Weighing and sieving the nutritional composition, fillers, disintegrants, glidants, and sweeteners; Mixing all the raw materials uniformly, and then adding lubricants and continuing to mix until uniform; Filling the mixed powder into HPMC or gelatin capsules, and packaging into capsules that meet the specifications.

[0017] Compared with the prior art, the present application has at least the following advantages: The nutritional composition disclosed herein comprises creatine monohydrate and wolfberry extract, with the weight ratio of creatine monohydrate to wolfberry extract ranging from 0.5:1 to 3:1. Experiments have shown that after taking this nutritional composition, muscle creatine phosphate (PCr) can be increased by 14% to 19%, and 1-RM strength can be increased by 6.1% to 8.5%, indicating that this nutritional composition has the effect of improving functional muscle strength and creatine phosphate levels. Furthermore, the effects produced by this nutritional composition far exceed the sum of the effects of each component alone, indicating that the combination of creatine monohydrate and wolfberry extract produces an unexpected and non-obvious synergistic effect in improving functional muscle strength and creatine phosphate levels. DETAILED DESCRIPTION

[0018] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments of the present invention can be combined with each other. The following will further describe the technical solution of the present invention in conjunction with the embodiments of the present invention, and the present invention is not limited to the following specific implementation methods.

[0019] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this application belongs. The terms used in the specification herein are for the purpose of describing specific embodiments only and are not intended to limit this application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0020] In one embodiment of the present invention, a novel nutritional composition comprises the creatine monohydrate and the wolfberry extract in a weight ratio of (0.5:1) to (3:1).

[0021] The molecular formula of creatine monohydrate in this application is C4H 11 N₃O₃·H₂O has a molecular weight of 149.15. The active ingredients in the Chinese wolfberry extract, extracted from the mature fruit of the Chinese wolfberry, include Chinese wolfberry polysaccharides, carotenoids, fat, protein, free amino acids, taurine, betaine, vitamin B1, vitamin B2, vitamin E, and vitamin C. In this application, the Chinese wolfberry extract is preferably in a concentrated form, such as an extract standardized to a high polysaccharide content, to ensure consistency and potency. Therefore, preferably, the Chinese wolfberry extract contains greater than 40% polysaccharides, and more preferably, the Chinese wolfberry extract contains 40% to 60% polysaccharides. The polysaccharide content in the Chinese wolfberry extract is determined using the phenol-sulfuric acid method, a commonly used colorimetric method for quantifying polysaccharide content, ensuring consistency and reproducibility.

[0022] Experiments have found that the combined effect of creatine monohydrate and wolfberry extract can significantly increase the level of phosphocreatine (PCr) in muscles and functional muscle strength (evaluated by 1-RM strength). When the weight ratio of creatine monohydrate and wolfberry extract is (0.5:1) to (3:1), PCr can be increased by 14% to 19%, and 1-RM strength can be increased by 6.1% to 8.5%. Furthermore, the weight ratio of creatine monohydrate and wolfberry extract is 2:1, which has the best effect on increasing the level of phosphocreatine (PCr) in muscles and 1-RM strength.

[0023] In another specific embodiment of the present application, the novel nutritional composition is used in nutritional supplements.

[0024] In a preferred embodiment, conventional excipients are added to the novel nutritional composition and prepared into a clinically acceptable dosage form according to conventional processes. Conventional excipients include fillers, disintegrants, glidants, and sweeteners. The dosage form includes, but is not limited to, granules, capsules, tablets, etc., depending on actual use needs.

[0025] Furthermore, the novel nutritional composition is prepared into a capsule, which includes the novel nutritional composition and excipients, wherein the excipients include a filler, a disintegrant, a lubricant, a glidant, and a sweetener. The mass ratio of the novel nutritional composition to the excipients is (1 to 2):1.

[0026] Furthermore, the filler includes any one of microcrystalline cellulose, hydroxypropyl cellulose, corn starch, pregelatinized starch, mannitol, sorbitol, etc.; the disintegrant includes any one of cross-linked carboxymethyl cellulose sodium, low-substituted hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone, sodium starch glycolate, etc.; the lubricant includes any one of magnesium stearate, calcium stearate, potassium stearate, polyethylene glycol, sodium lauryl sulfate, etc.; the glidant includes any one of silicon dioxide, talc, corn starch, etc.; the sweetener includes any one of sucrose, lactose, mannitol, sorbitol, aspartame, steviol glycoside, etc.

[0027] In another specific embodiment of the present application, the preparation method of the above-mentioned capsule comprises the following steps: The nutritional composition, filler, disintegrant, glidant and sweetener are weighed and sieved; all the raw materials are mixed evenly, and then a lubricant is added and the mixture is continued until uniform; the mixed powder is filled into HPMC or gelatin capsules and encapsulated into capsules that meet the specifications.

[0028] The following is a detailed description of the technical solutions and effects of the present invention through specific experimental examples.

[0029] 1. Experimental Materials and Methods 1.1 Experimental Materials Creatine monohydrate: from Ningxia Hengkang Technology Co., Ltd., purity 98%.

[0030] Lycium barbarum extract: contains 50% Lycium barbarum polysaccharides, from Bairuiyuan Lycium barbarum Co., Ltd.

[0031] Placebo drink: Red Bull.

[0032] 1.2 Experimental methods To evaluate changes in muscle phosphocreatine levels (PCr) and one-repetition maximum (1-RM) in recreational athletes during a 4-week supplementation period.

[0033] Four groups of five amateur athletes were recruited, all maintaining a consistent diet and exercise intensity. Key physiological parameters were measured before supplementation (baseline) and again after four weeks. The primary outcome measures were: Intramuscular creatine phosphate (PCr) levels, as measured by 31 P-Magnetic Resonance Spectroscopy ( 31 P-MRS) is a non-invasive measurement that reflects muscle energy storage capacity.

[0034] One-repetition maximum (1-RM) strength in the bench press, representing maximal force output, was calculated for each individual relative to their baseline to assess improvement.

[0035] 2. Example 1 Comparative Group 1: Each person consumed 500ml of a placebo drink (Red Bull) daily to account for any training or psychological effects.

[0036] Comparative group 2: Each person took 4.5g of creatine monohydrate per day. The specific method was: 4.5g of creatine monohydrate was dissolved in 500ml of pure water and then drank.

[0037] Comparative group 3: Each person took 4.5g of wolfberry extract every day. The specific method was: dissolve 4.5g of wolfberry extract in 500ml of pure water and drink it.

[0038] Experimental group 1: Each person took 4.5 g of the nutritional composition per day. The specific method was: 2.25 g of creatine monohydrate and 2.25 g of wolfberry extract were dissolved in 500 ml of purified water and the mixture was drunk.

[0039] Table 1 Mean percentage improvement relative to baseline after four weeks

[0040] Please see Table 1. Under the premise of consistent diet and exercise intensity, the control group 1 took a placebo drink. The group showed only trivial changes, confirming that the observed gains were due to the supplement and not training effects or measurement error. All differences were statistically significant for Experimental Group 1 compared to the placebo group (Comparison Group 1) and each of the individual ingredient groups (Comparison Groups 2, 3), emphasizing that the benefits of the combination supplement were real and robust.

[0041] After four weeks of taking the wolfberry extract, there were no significant changes in the average PCr increase and average 1-RM strength increase from baseline for Comparison Group 3. While Comparison Group 2 showed significant increases in PCr and 1-RM strength from taking creatine monohydrate, Experimental Group 1, which took the nutritional composition of the present application, increased muscle PCr by 19% and 1-RM strength by 7.2%, indicating that the wolfberry extract-creatine monohydrate combination facilitated the uptake or retention of enhanced phosphocreatine in muscle beyond that which could be achieved with creatine monohydrate alone. This indicates that subjects taking the nutritional composition of the present application increased more PCr and provided greater strength gains than subjects taking an equivalent amount of creatine without wolfberry.

[0042] 3. Example Two To determine how the ratio of creatine to wolfberry affected the synergistic results, further studies were conducted with various formulations covering a range of ratios from 0.5:1 to 3:1 (weight ratio of creatine monohydrate to wolfberry extract). In these trials, the dose of the nutritional composition was held constant (4.5 g / day) while the ratio of creatine monohydrate to wolfberry extract was adjusted.

[0043] Experimental Group 2: Each person took 4.5 g of the nutritional composition per day by dissolving 1.5 g of creatine monohydrate and 3 g of wolfberry extract in 500 ml of purified water and drinking it.

[0044] Experimental Group 3: Each person took 4.5 g of the nutritional composition per day by dissolving 3 g of creatine monohydrate and 1.5 g of wolfberry extract in 500 ml of purified water and drinking it.

[0045] Experimental Group 4: Each person took 4.5 g of the nutritional composition per day by dissolving 3.375 g of creatine monohydrate and 1.125 g of wolfberry extract in 500 ml of purified water and drinking it.

[0046] Table 2 Average Percent Improvement from Baseline after Four Weeks

[0047] As can be seen from the table above, while maintaining the same total daily intake of the nutritional composition, varying the ratio of creatine monohydrate to wolfberry extract in the nutritional composition produces different effects on the human body. Given the same total nutritional composition intake, those who consumed either less creatine monohydrate (Experimental Group 2) or less wolfberry extract (Experimental Group 4) showed slightly lower increases in PCr and 1-RM strength than the other two experimental groups, but greater than those who took creatine monohydrate alone (Control Group 2).

[0048] The most effective results were achieved in Experimental Group 3, where the ratio of creatine monohydrate to wolfberry extract was 2:1. The average PCr increase reached 19%, a 7% increase compared to creatine monohydrate alone (Control Group 2), with a 58.3% improvement rate. The average 1-RM strength increase reached 8.5%, a 3% increase compared to creatine monohydrate alone, with a 54.5% improvement rate. This demonstrates that a 2:1 ratio of creatine monohydrate to wolfberry extract produces the most synergistic effect. It is worth noting that while the data indicates a 2:1 ratio of creatine monohydrate to wolfberry extract is optimal, the present invention is not limited to this ratio. Any formula within the range of 0.5:1 to 3:1 falls within the scope of the present invention. Combining creatine monohydrate with wolfberry extract at these ratios significantly surpasses the effects of creatine monohydrate alone, demonstrating that they all achieve synergistic effects to varying degrees.

[0049] 4. Example 3: Preparation of nutritional composition capsules Formula (500mg per capsule): 300mg of nutritional composition, containing 200mg (40%) of creatine monohydrate and 100mg (20%) of wolfberry extract (containing 50% polysaccharides); Excipients: 200 mg, including microcrystalline cellulose (filler) 150 mg (30%); cross-linked carboxymethyl cellulose sodium (disintegrant) 20 mg (4%); magnesium stearate (lubricant) 5 mg (1%); silicon dioxide (glidant) 5 mg (1%); steviol glycosides (sweetener) 20 mg (4%).

[0050] Preparation process: The above dosage of nutritional composition, filler, disintegrant, glidant and sweetener are weighed and sieved; all raw materials are mixed evenly, and then a lubricant is added and the mixture is continued until uniform; the mixed powder is filled into HPMC or gelatin capsules and encapsulated into capsules that meet the specifications.

[0051] The above embodiments only express several implementation ways of the present application, and the description is specific and detailed, but it should not be understood as a limitation to the patent scope of the application. It should be pointed out that for ordinary skilled in the art, without departing from the concept of the present application, several modifications and improvements can be made, which all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.

Claims

1. A novel nutritional composition, characterized in that: The invention comprises creatine monohydrate and wolfberry extract, wherein the weight ratio of the creatine monohydrate to the wolfberry extract is (0.5:1) to (3:1).

2. The novel nutritional composition according to claim 1, characterized in that The weight ratio of the creatine monohydrate to the wolfberry extract is 2:

1.

3. The novel nutritional composition according to claim 1, characterized in that The wolfberry extract contains more than 40% polysaccharide.

4. The novel nutritional composition according to claim 3, characterized in that The wolfberry extract contains 40% to 60% polysaccharides.

5. Use of the novel nutritional composition according to any one of claims 1 to 4 in nutritional supplements.

6. The use according to claim 5, characterized in that Conventional auxiliary materials are added to the novel nutritional composition, and a clinically acceptable dosage form is prepared according to conventional processes.

7. The use according to claim 6, characterized in that The novel nutritional composition is prepared into capsules, which include the novel nutritional composition and auxiliary materials, wherein the auxiliary materials include fillers, disintegrants, lubricants, glidants and sweeteners.

8. The use according to claim 7, characterized in that The mass ratio of the novel nutritional composition to the auxiliary material is (1 to 2):

1.

9. The use according to claim 7, characterized in that The filler includes any one of microcrystalline cellulose, hydroxypropyl cellulose, corn starch, pregelatinized starch, mannitol, sorbitol, etc.; the disintegrant includes any one of cross-linked carboxymethyl cellulose sodium, low-substituted hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone, sodium starch glycolate, etc.; the lubricant includes any one of magnesium stearate, calcium stearate, potassium stearate, polyethylene glycol, sodium lauryl sulfate, etc.; the glidant includes any one of silicon dioxide, talc, corn starch, etc.; the sweetener includes any one of sucrose, lactose, mannitol, sorbitol, aspartame, steviol glycoside, etc.

10. The method for preparing the capsule according to claim 7, wherein: The following steps are involved: Weighing and sieving the nutritional composition, filler, disintegrant, glidant and sweetener; Mix all ingredients well, then add lubricant and continue mixing until smooth; The mixed powder is put into HPMC or gelatin capsules and encapsulated into capsules that meet the specifications.

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