Lip moistening composition as well as preparation method and application thereof

Abstract

The invention provides a lip-moistening composition as well as a preparation method and application thereof, and belongs to the technical field of lip-moistening compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1.6 to 2.4 parts of flos carthami, 3.2 to 4.8 parts of flos rosae rugosae, 0.4 to 0.6 part of radix angelicae sinensis, 0.4 to 0.6 part of pericarpium citri reticulatae, 0.2 to 0.3 part of fructus hippophae and 0.2 to 0.3 part of fructus lycii. The traditional Chinese medicine composition is clear in whole formula compatibility, simple in medicine and specific in effect, the total effective rate for treating chronic cheilitis reaches 76% or above, the recurrence rate is remarkably reduced, and the composition is suitable for repairing chronic cheilitis, chapped lips and hyperpigmentation and preventing cheilitis recurrence. The composition is natural and safe in components and wide in universality, has the safety of food and the effect of medicines, has the property of homology of medicine and food, and is very safe and reliable when acting on lips.

Description

Technical Field

[0001] The present invention belongs to the technical field of lip balm compositions, and in particular relates to a lip balm composition, a preparation method thereof, and an application thereof. Background Art

[0002] Lips are a special part of the human skin. With a thin stratum corneum and no hair follicles or sweat glands, they are prone to moisture loss and are highly susceptible to environmental irritation, leading to dryness, peeling, and pigmentation. As people become more aware of the beauty and health of their lips, the market demand for products that repair and moisturize their lips continues to grow.

[0003] Currently, mainstream lip balms on the market are mostly based on chemically synthesized ingredients. For example, ≥60% of products use polyethylene glycol (PEG) as the main moisturizing ingredient. While it can temporarily lock in moisture, long-term use may damage the natural barrier of the lip skin. Preservatives such as methylparaben, while they can extend the shelf life of the product, carry the risk of causing skin allergies and contact dermatitis. Chemical sunscreens, while absorbing ultraviolet rays, can also penetrate into the human body, posing potential health risks. Furthermore, these products generally suffer from three major technical flaws: ① They only physically cover the lip surface and fail to deeply repair mucosal cells (for example, a clinical trial of a certain petrolatum lipstick showed a 41% recurrence rate of dryness and cracking after 3 days of discontinuation); ② poor ingredient synergy, making it difficult for a single active ingredient to address the multifactorial pathology of cheilitis; and ③ long-term safety is questionable, as synthetic ingredients may disrupt the balance of the lip microbiome. Furthermore, some products are prone to addiction after use, and once discontinued, lip problems can relapse severely.

[0004] Food and drug substances refer to items that can function as both food and medicine. They are highly safe and possess diverse biological activities, demonstrating enormous potential for application. However, the research and development of their application in lip balm products is still in its infancy. Most existing products have single ingredients and fail to fully exploit the synergistic effects of these substances, preventing them from providing comprehensive and effective treatment for dry and damaged lips. Therefore, the development of a lip-repairing and lip-smoothing food and drug substance combination is crucial for filling this market gap and promoting the development of lip balm products towards safety and efficacy. Summary of the Invention

[0005] In view of this, the object of the present invention is to provide a lip balm composition, the raw materials of which are both food safe and medicinal, have the effects of relieving dryness, anti-inflammatory and repairing, can improve chronic cheilitis and reduce its recurrence rate.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The present invention aims to provide a lip balm composition, which comprises the following raw materials in parts by weight: 1.6 to 2.4 parts of safflower, 3.2 to 4.8 parts of rose, 0.4 to 0.6 part of angelica, 0.4 to 0.6 part of tangerine peel, 0.2 to 0.3 part of sea buckthorn, and 0.2 to 0.3 part of wolfberry.

[0008] Preferably, the following raw materials are included in parts by weight: 2 parts of safflower, 4 parts of rose, 0.5 parts of angelica, 0.5 parts of tangerine peel, 0.25 parts of sea buckthorn, and 0.25 parts of wolfberry.

[0009] Another object of the present invention is to provide a method for preparing the lip balm composition, comprising the following steps: weighing the raw materials in proportion, mixing and sieving to obtain a mixed coarse powder; mixing the mixed coarse powder with coconut oil and then soaking; performing ultrasound-assisted extraction after soaking to obtain an extract; refluxing the extract and condensing to recover volatile oil; mixing the reflux extract with the volatile oil and filtering, concentrating the filtrate to obtain a concentrated solution; and mixing the concentrated solution with white beeswax.

[0010] Preferably, the mass ratio of the coarse powder to the coconut oil is 1:(4-6).

[0011] Preferably, the soaking is performed at 55-65° C. for 10-14 hours.

[0012] Preferably, the conditions for ultrasound-assisted extraction are: extraction temperature of 55-65° C., extraction time of 1.5-2.5 h, ultrasound power of 250-350 W, and ultrasound frequency of 35-45 kHz.

[0013] Preferably, the temperature of the reflux extraction is 75-85° C., and the reflux time is 2.5-3.5 h.

[0014] Preferably, the mass ratio of the mixed coarse powder to white beeswax is 1:(1.6-1.8).

[0015] Another object of the present invention is to provide use of the lip balm composition or the preparation method in preparing products for treating and / or preventing cheilitis.

[0016] Another object of the present invention is to provide a repairing lip balm containing the lip balm composition.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The present invention provides a lip balm composition. The present invention has a clear formula and a simple and effective medicine. It is effective in promoting blood circulation, removing blood stasis, unblocking meridians, nourishing yin, moistening dryness and promoting tissue regeneration, targeting qi and blood stasis in the lips caused by repeated attacks of chronic cheilitis, as well as dryness and desquamation caused by yin-blood deficiency and wind-dryness damaging body fluid. The present invention has the effect of nourishing blood while promoting blood circulation, and can quickly relieve the dryness and cracking of the lips, taking both attacking and replenishing measures. The present invention achieves the effects of dispersing wind, clearing heat and regulating qi by dispersing local stagnant heat and preventing damp-heat stagnation. The present invention can effectively improve the dullness and dryness of the lips, relieve chronic cheilitis, and prevent the recurrence of cheilitis. The ingredients of the composition of the present invention are natural and safe, with wide universality. It has both the safety of food and the effect of medicine, and has the property of being both a medicine and a food. It is very safe and reliable to act on the lips. DETAILED DESCRIPTION

[0019] The present invention provides a lip balm composition, which comprises the following raw materials in parts by weight: 1.6-2.4 parts of safflower, 3.2-4.8 parts of rose, 0.4-0.6 parts of angelica, 0.4-0.6 parts of dried tangerine peel, 0.2-0.3 parts of sea buckthorn, and 0.2-0.3 parts of wolfberry. Preferably, the composition comprises the following raw materials in parts by weight: 2 parts of safflower, 4 parts of rose, 0.5 parts of angelica, 0.5 parts of dried tangerine peel, 0.25 parts of sea buckthorn, and 0.25 parts of wolfberry.

[0020] In the present invention, safflower and rose are used as the main medicines. Safflower can promote blood circulation and remove blood stasis, dredge meridians and relieve pain. It targets the main cause of "blood stasis", promotes local microcirculation, repairs damaged mucosa, and can improve the dark redness, swelling and cracking caused by blood stasis on the lips. The antioxidant ingredients it contains can assist in anti-inflammatory; rose can soothe the liver and harmonize blood, promote qi and relieve depression, and has a moisturizing property, which can relieve dryness and desquamation on the lips. Rose can reconcile the poor distribution of body fluids caused by liver qi stagnation, and has the dual effects of "promoting blood circulation" and "moisturizing dryness", which can relieve dryness and soften cuticles; safflower and rose are used together and play a leading role in the prescription, so that the prescription has the effects of promoting blood circulation and removing blood stasis, moisturizing dryness and promoting tissue regeneration. Angelica and dried tangerine peel are auxiliary drugs. Angelica nourishes blood, promotes blood circulation, relieves pain, moisturizes dryness and promotes tissue regeneration. It can be used to treat carbuncles and ulcers. It can not only promote blood circulation, reduce swelling and relieve pain, but also nourish blood and promote tissue regeneration. It assists safflower in enhancing its ability to remove blood stasis, while nourishing yin and moistening dryness to repair chapped lips; dried tangerine peel regulates qi and strengthens the spleen, dries dampness and resolves phlegm, promotes qi to help the penetration of blood-activating drugs, and prevents dampness and turbidity stagnation from aggravating cheilitis; the two are used together to assist the main drug in exerting the effect of promoting blood circulation and removing blood stasis, while making the formula have the effect of clearing heat and nourishing blood. It is a combination of attack and supplement, which can not only promote blood circulation and remove blood stasis, but also nourish blood and reduce dryness. Sea buckthorn and wolfberry are adjuvants. Sea buckthorn can promote blood circulation and dissipate blood stasis, clear away heat and promote the production of body fluid, and assist in resolving local blood stasis and heat. It is rich in vitamin C and can promote mucosal repair. Wolfberry nourishes the yin of the liver and kidneys, moisturizes and relieves itching, balances the pungent and dispersing properties of safflower and tangerine peel, prevents further loss of body fluid in the lips, can moisturize and lock in water, resist inflammation, and reduce redness and swelling caused by environmental stimuli. Sea buckthorn and wolfberry, as adjuvants, further enhance the efficacy of the formula in promoting blood circulation and removing blood stasis, and make the formula have the effects of nourishing yin, moisturizing and regulating qi.

[0021] The present invention has a clear prescription, simple medicine and specific efficacy. It is effective in promoting blood circulation, removing blood stasis and unblocking meridians, nourishing yin, moistening dryness and promoting tissue regeneration, targeting the stagnation of qi and blood in the lips (manifested as lip microcirculation disorders) caused by repeated attacks of chronic cheilitis, as well as yin and blood deficiency (manifested as decreased mucosal repair ability), and dryness and desquamation caused by wind and dryness damaging body fluid. The present invention not only promotes blood circulation but also nourishes blood, can quickly relieve the dryness and cracking of the lips, and has both attacking and replenishing effects. The present invention disperses local stagnant heat and prevents damp-heat stagnation, achieving the effects of dispersing wind, clearing heat and regulating qi, preventing recurrence of cheilitis and significantly reducing the recurrence rate of cheilitis.

[0022] The raw materials in the present invention can be obtained through common commercial channels. The coconut oil in the specific embodiment of the present invention is pharmaceutical grade coconut oil (conforming to the standards of the Chinese Pharmacopoeia, with an acid value of ≤1 mg / g).

[0023] The present invention also provides a method for preparing the lip balm composition, comprising the following steps: weighing each raw material in proportion, mixing and crushing, and sieving to obtain a mixed coarse powder; mixing the mixed coarse powder with coconut oil and then soaking; performing ultrasonic-assisted extraction after soaking to obtain an extract; refluxing the extract and condensing to recover the volatile oil; mixing the reflux extract with the volatile oil and filtering, concentrating the filtrate to obtain a concentrate; and mixing the concentrate with white beeswax. In the present invention, it is preferred that the mixture after the reflux extract and the volatile oil is filtered while hot, and the hot filtration is to keep the mixture at 70-80°C (water bath) and then filter immediately. The present invention can avoid the coagulation of lipids when the temperature is below 55°C by filtering while hot, prevent clogging of the filter pores, maintain a low viscosity of the mixture to improve filtration efficiency, and at the same time reduce the precipitation of dissolved impurities into the mixture after cooling. As an practicable method, the present invention adopts a double-layer filter paper vacuum filtration method for filtration.

[0024] In the method of the present invention, it is preferred that the powder be sieved through a 50-70 mesh sieve after pulverization, more preferably through a 60 mesh sieve. The mass ratio of the coarse powder to coconut oil is preferably 1:(4-6), and in some embodiments, it can be 1:4, 1:5 or 1:6. Coconut oil is a natural skin-friendly oil that can quickly penetrate and soften keratin, moisturize the skin, form a lipid protective film, and relieve dry lips. At the same time, as a solvent, it can not only effectively extract the active ingredients in the raw materials, but also promote transdermal absorption of drugs. In the present invention, the coarse powder is preferably mixed with coconut oil and pre-soaked. The temperature is controlled by a water bath during soaking. The soaking temperature is preferably 55-65°C, and in some embodiments, it can be 55°C, 60°C or 65°C; the soaking time is preferably 10-14h, and in some embodiments, it can be 10h, 12h or 14h. In the present invention, the extraction temperature for ultrasonic-assisted extraction is preferably 55-65°C, and in some embodiments, it can be 55°C, 60°C, or 65°C; the ultrasonic-assisted extraction time is preferably 1.5-2.5 hours, and in some embodiments, it can be 1.5 hours, 2 hours, or 2.5 hours; the ultrasonic power is preferably 250-350W, and in some embodiments, it can be 250W, 260W, 270W, 280W, 290W, 300W, 310W, 320W, 330W, 340W, or 350W; the ultrasonic power is preferably 35-45kHz, and in some embodiments, it can be 35kHz, 40kHz, or 45kHz. In the present invention, the temperature for reflux extraction is preferably 75-85°C, and in some embodiments, it can be 75°C, 80°C, or 85°C; the reflux extraction time is preferably 2.5-3.5 hours, and in some embodiments, it can be 2.5 hours, 3.0 hours, or 3.5 hours. The concentration described in the present invention is preferably concentrated to 1 / 2 to 2 / 3 of the original volume. As an practicable method, the present invention adopts a rotary evaporator for concentration. The amount of white beeswax added in the present invention is based on the mass of the mixed coarse powder, and the mass ratio of the mixed coarse powder to the white beeswax is preferably 1: (1.6 to 1.8), and in some embodiments it can be 1: 1.6, 1: 1.7 or 1: 1.8. White beeswax is an excipient for solidifying the paste, locking in moisture, enhancing the adhesion of the lipstick, and prolonging the residence time of the drug to maintain the therapeutic effect. After the white beeswax is mixed with the concentrated solution, it is preferably melted in a water bath at 70 to 80°C, and in some embodiments it can be 70°C, 75°C or 80°C; after melting, it is magnetically stirred until homogeneous. Quickly inject it into the mold while hot, and cool and solidify it into shape.

[0025] The present invention also provides the use of the lip balm composition or the preparation method in preparing a product for treating and / or preventing cheilitis. The composition of the present invention can improve dull lips, keep lips moisturized, effectively relieve chronic cheilitis, and reduce the recurrence rate.

[0026] The present invention also provides a repairing lip balm containing the lip balm composition.

[0027] The technical solutions provided by the present invention are described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0028] Example 1

[0029] A lip balm composition, comprising the following raw materials in parts by weight:

[0030] 2 parts of safflower, 4 parts of rose flowers, 0.5 part of angelica, 0.5 part of dried tangerine peel, 0.25 part of sea buckthorn, and 0.25 part of wolfberry.

[0031] Preparation method:

[0032] Weigh the raw materials in proportion, mix and grind them, pass through a 60-mesh sieve to obtain a mixed coarse powder, mix the mixed coarse powder with coconut oil in a mass ratio of 1:5, and pre-soak in a 60°C water bath for 12 hours.

[0033] After soaking, ultrasonic-assisted extraction was performed at a temperature of 60° C. and a time of 2 h (ultrasonic power of 300 W and frequency of 40 kHz) to obtain an extract.

[0034] The extract was subjected to reflux extraction at a temperature of 80°C for 3 h. The volatile oil was recovered through a condenser, and the reflux extract and the volatile oil were combined and vacuum filtered using double-layer filter paper while hot. The filtrate was concentrated to 2 / 3 of the original volume using a rotary evaporator to obtain a concentrated solution.

[0035] Mix the concentrate with white beeswax, with the weight of the coarse powder being the mass ratio of the coarse powder to the white beeswax being 1:1.7. Melt the mixture in a 75°C water bath and stir magnetically until homogeneous. Quickly pour the mixture into a mold while hot and allow it to solidify under cooling to form the lip balm.

[0036] Example 2

[0037] A lip balm composition is different from Example 1 in that the mixed coarse powder and coconut oil are mixed in a mass ratio of 1:6.

[0038] Example 3

[0039] A lip balm composition is different from Example 1 in that the mixed coarse powder and coconut oil are mixed in a mass ratio of 1:4.

[0040] Example 4

[0041] A lip balm composition, comprising the following raw materials in parts by weight:

[0042] 2 parts of safflower, 3.5 parts of rose, 0.45 part of angelica, 0.55 part of dried tangerine peel, 0.2 part of sea buckthorn, and 0.2 part of wolfberry.

[0043] The preparation method is the same as that of Example 1.

[0044] Example 5

[0045] A lip balm composition, comprising the following raw materials in parts by weight:

[0046] 2.4 parts of safflower, 4.5 parts of rose, 0.55 parts of angelica, 0.45 parts of dried tangerine peel, 0.3 parts of sea buckthorn, and 0.3 parts of wolfberry.

[0047] The preparation method is the same as that of Example 1.

[0048] Comparative Example 1

[0049] A lip balm composition is different from Example 1 in that the mixed coarse powder and coconut oil are mixed in a mass ratio of 1:10.

[0050] Comparative Example 2

[0051] A lip balm composition is different from Example 1 in that the mixed coarse powder and coconut oil are mixed in a mass ratio of 1:3.

[0052] Comparative Example 3

[0053] A lip balm composition, which differs from Example 3 in that safflower is not added.

[0054] Comparative Example 4

[0055] A lip balm composition, which differs from Example 3 in that no angelica is added.

[0056] Comparative Example 5

[0057] A lip balm composition is provided, which differs from Example 3 in that safflower is replaced with an equal amount of salvia miltiorrhiza.

[0058] Comparative Example 6

[0059] A lip balm composition, which differs from Example 3 in that seabuckthorn is replaced with an equal amount of vitamin E.

[0060] The preparation method is as follows: weigh each Chinese medicinal raw material in proportion, grind after mixing, pass through a 60-mesh sieve to obtain a mixed coarse powder, mix the mixed coarse powder with coconut oil in a mass ratio of 1:5, and pre-soak in a 60°C water bath for 12 hours.

[0061] After soaking, ultrasonic-assisted extraction was performed at a temperature of 60° C. and a time of 2 h (ultrasonic power of 300 W and frequency of 40 kHz) to obtain an extract.

[0062] The extract was subjected to reflux extraction at a temperature of 80° C. for 3 h, and the volatile oil was recovered by condensation. The reflux extract was mixed with the volatile oil and vacuum filtered using double-layer filter paper. The filtrate was concentrated to 2 / 3 of the original volume using a rotary evaporator to obtain a concentrated solution.

[0063] Mix the concentrate with vitamin E and white beeswax. The amount of white beeswax added is based on the mass of the mixed coarse powder, and the mass ratio of the mixed coarse powder to the white beeswax is 1:1.7. After mixing, melt in a 75°C water bath and stir magnetically until homogeneous. While hot, quickly pour into a mold and cool to solidify to obtain a lip balm.

[0064] Comparative Example 7

[0065] A lip balm composition, comprising the following raw materials in parts by weight:

[0066] 8 parts of safflower, 2 parts of rose flowers, 0.5 part of angelica, 0.5 part of dried tangerine peel, 0.25 part of sea buckthorn, and 0.25 part of wolfberry.

[0067] The preparation method is the same as that of Example 1.

[0068] Comparative Example 8

[0069] A lip balm composition is different from Example 1 in that: after the mixed coarse powder is pre-soaked with coconut oil, reflux extraction is directly performed, and the ultrasound-assisted extraction step is omitted.

[0070] Example 6

[0071] Effects of different lip balm compositions.

[0072] A total of 700 patients with chronic cheilitis caused by bad habits were included.

[0073] 1. The inclusion criteria for patients with chronic cheilitis are as follows:

[0074] (1) Poor lip habits; (2) Clinical manifestations of chronic cheilitis; (3) No cleft lip or palate, other systemic immune and psychological problems; (4) No history of lip surgery, trauma, or abnormal lip morphology; (5) Exclusion of lip inflammation caused by other factors, such as light exposure, allergies, etc.; (6) Good compliance; (7) Patients have complete lip information; (8) Voluntary signing of the informed consent form.

[0075] 2. The exclusion criteria for patients with chronic cheilitis are as follows:

[0076] (1) Women who are pregnant or breastfeeding, or individuals who plan to have children within the next three months; (2) People with allergic constitutions; (3) People with confirmed skin diseases or a history of chronic systemic diseases; (4) The test area has obvious birthmarks, abnormal pigmentation, active inflammatory reactions, scar tissue, pigmented moles or excessive hair growth; (5) Systemic or topical use of glucocorticoid preparations or other anti-inflammatory drugs within 30 days; (6) Contact with functional skin care products or other similar products involved in the test within 14 days; (7) Participation in other cosmetic human testing projects within 30 days; (8) Other clinical indications determined by the researchers to be unsuitable for participation in the trial.

[0077] 3. Ethics and Compliance:

[0078] (1) Comply with the Declaration of Helsinki; (2) Provide free emergency consultation with dermatologists; (3) Subjects have the right to withdraw from the experiment at any time.

[0079] 4. Patients with chronic cheilitis were randomly divided into 14 groups. Thirteen of these groups corrected their bad habits and applied 0.2 g of the lip balm obtained in Examples 1 to 5 and Comparative Examples 1 to 8 four times daily for three months. The remaining group, designated the control group, only corrected their bad habits for three months. The improvement in cheilitis was assessed after three months.

[0080] The evaluation criteria for cheilitis treatment effect are:

[0081] (1) Significantly effective: clinical manifestations include significant relief of red lip symptoms and a healing ratio of >2 / 3 of the cheilitis area; (2) Improved: clinical manifestations include slight relief of red lip symptoms and a healing ratio of 1 / 3 to 2 / 3 of the cheilitis area; (3) Ineffective: clinical manifestations include no relief of red lip symptoms and a healing ratio of <1 / 3 of the cheilitis area.

[0082] Cheilitis area healing ratio = (cheilitis area ratio before treatment - cheilitis area ratio after treatment) / cheilitis area ratio before treatment; total effective rate of cheilitis treatment = (number of effective cases + number of improved cases) / total number of cases × 100%.

[0083] Patients were followed up five days after the three-month lipstick application to investigate the recurrence of chronic cheilitis. Recurrence rate = number of recurrences / total number of cases × 100%.

[0084] 5. Statistical Analysis

[0085] SPSS 28.0 software was used for statistical analysis of the data. 2 The results were analyzed using the statistician's test. A P value < 0.05 was considered statistically significant. The results are shown in Tables 1 and 2.

[0086] Table 1 Treatment effect of cheilitis

[0087] Sample size / case Significantly effective / case Effective / Example Invalid / Example Total effective rate / % Recurrence / case Recurrence rate / % Example 1 50 24 20 6 88.00 4 8.00 Example 2 50 20 18 12 76.00 6 12.00 Example 3 50 26 18 6 88.00 8 16.00 Example 4 50 22 19 9 82.00 6 12.00 Example 5 50 23 18 9 82.00 7 14.00 control group 50 10 14 26 48.00 12 24.00 Comparative Example 1 50 12 16 22 56.00 9 18.00 Comparative Example 2 50 18 16 16 68.00 8 16.00 Comparative Example 3 50 8 12 30 40.00 18 36.00 Comparative Example 4 50 15 18 17 66.00 10 20.00 Comparative Example 5 50 18 16 16 68.00 9 18.00 Comparative Example 6 50 20 17 13 74.00 7 14.00 Comparative Example 7 50 10 14 26 48.00 12 24.00 Comparative Example 8 50 16 18 16 68.00 10 20.00

[0088] Table 2χ 2 Test results

[0089] Total efficiency Recurrence rate Total efficiency Recurrence rate Example 1 vs control group P<0.01 P<0.05 Comparative Example 3 vs Example 1 P<0.01 P<0.01 Example 2 vs control group P<0.01 P＞0.05 Comparative Example 4 vs Example 1 P<0.01 P<0.05 Example 3 vs. control group P<0.01 P＞0.05 Comparative Example 5 vs Example 1 P<0.01 P<0.05 Example 4 vs Example 1 P＞0.05 P＞0.05 Comparative Example 6 vs Example 1 P<0.05 P<0.05 Example 5 vs Example 1 P＞0.05 P＞0.05 Comparative Example 7 vs Example 1 P<0.01 P<0.01 Comparative Example 1 vs Example 1 P<0.01 P<0.05 Comparative Example 8 vs Example 1 P<0.01 P<0.05 Comparative Example 2 vs Example 1 P<0.05 P<0.05

[0090] The results in Tables 1 and 2 indicate that the present invention can effectively improve chronic cheilitis and has a low recurrence rate. The results of Comparative Examples 1 and 2 show that when coconut oil is used to extract the active ingredient of the composition, the amount of coconut oil used affects the improvement effect of the composition on chronic cheilitis and the effect of reducing the recurrence rate. In Comparative Example 3, safflower was omitted, resulting in a loss of the blood-activating and blood-stasis-removing function, a significant decrease in the total effective rate, and a surge in the recurrence rate. In Comparative Example 4, the absence of angelica affected the blood-tonifying and myogenic function, resulting in a decrease in wound repair ability, and a significant decrease in both efficacy and recurrence prevention. In Comparative Example 5, safflower was replaced with salvia miltiorrhiza. Although salvia miltiorrhiza has a blood-activating effect, it lacks the antioxidant components unique to safflower, and its efficacy and recurrence prevention effects are inferior to those of Example 1. In Comparative Example 6, vitamin E was used to replace sea buckthorn. Vitamin E only provides antioxidant function and cannot replace the repair and moisturizing synergistic effects of sea buckthorn, resulting in a reduced efficacy. In Comparative Example 7, the excessive amount of safflower added caused local irritation, an imbalance in the ratio of monarch and ministerial herbs, and a significant decrease in efficacy. Comparative Example 8 only adopts reflux extraction, which results in insufficient release of the active ingredients of the raw materials in the formula and reduced efficacy.

[0091] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A lip balm composition, characterized in that: The raw materials are as follows, calculated by weight: 1.6-2.4 parts of safflower, 3.2-4.8 parts of rose, 0.4-0.6 part of angelica, 0.4-0.6 part of tangerine peel, 0.2-0.3 part of sea buckthorn, and 0.2-0.3 part of wolfberry.

2. The lip balm composition according to claim 1, characterized in that The preparation comprises the following raw materials in parts by weight: 2 parts of safflower, 4 parts of rose, 0.5 parts of angelica, 0.5 parts of dried tangerine peel, 0.25 parts of sea buckthorn, and 0.25 parts of wolfberry.

3. The method for preparing the lip balm composition according to claim 1 or 2, characterized in that: The method comprises the following steps: weighing raw materials in proportion, mixing and sieving to obtain a mixed coarse powder; mixing the mixed coarse powder with coconut oil and then soaking the mixture; performing ultrasonic-assisted extraction after soaking to obtain an extract; refluxing the extract and condensing to recover volatile oil; mixing the reflux extract with the volatile oil and filtering, concentrating the filtrate to obtain a concentrated solution; and mixing the concentrated solution with white beeswax.

4. The preparation method according to claim 3, characterized in that The mass ratio of the coarse powder to the coconut oil is 1:(4-6).

5. The preparation method according to claim 3, characterized in that The soaking is performed at 55-65° C. for 10-14 hours.

6. The preparation method according to claim 3, characterized in that The conditions for ultrasound-assisted extraction are: extraction temperature of 55-65° C., extraction time of 1.5-2.5 h, ultrasound power of 250-350 W, and ultrasound frequency of 35-45 kHz.

7. The preparation method according to claim 6, characterized in that The temperature of the reflux extraction is 75-85° C., and the reflux time is 2.5-3.5 hours.

8. The preparation method according to claim 1, characterized in that The mass ratio of the mixed coarse powder to white beeswax is 1:(1.6-1.8).

9. Use of the lip balm composition according to claim 1 or 2 or the preparation method according to any one of claims 3 to 8 in preparing a product for treating and / or preventing cheilitis.

10. A lip balm for repairing, characterized in that: Contains the lip balm composition according to claim 1 or 2.