Traditional Chinese medicine composition for improving stool character

Abstract

The invention relates to a traditional Chinese medicine composition for improving stool characters, and belongs to the technical field of traditional Chinese medicine preparations. The composition is prepared from potamogeton pectinatus, oriental wormwood, jerusalem artichoke, humifuse euphorbia herb, liquorice and astragalus membranaceus. In the composition, potamogeton pectinatus degrades intestinal mucoprotein MUC2 and bidirectionally adjusts the water content of excrement; artemisia capillaris inhibits putrefying bacteria proliferation, adjusts bilirubin metabolism and improves stool color. The jerusalem artichoke inhibits synthesis of hydrogen sulfide through prebiotics and short-chain fatty acid and eliminates stink; the humifuse euphorbia herb can repair intestinal mucosal barriers; licorice root anti-inflammatory film protection; astragalus membranaceus promotes protein digestion and absorption. The composition can be prepared into dosage forms such as tablets, particles and capsules, can remarkably improve viscous, thin and loose or dry and uneven states of excrement, promote discharge of formed soft excrement, relieve adhesion of excrement bodies, adjust the color of the excrement to be brownish yellow and reduce stink and exhaust, has no drug dependence risk, and is suitable for functional abnormal defecation caused by dietary imbalance of healthy people.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for improving stool characteristics. Background Art

[0002] With the change of people's nutritional concepts and the accelerated pace of life, a diet characterized by high animal protein intake has become widely popular among healthy people. The average daily protein intake per person generally exceeds the recommended standard, and animal protein accounts for more than 35% of the total calories of some people, far exceeding the grain-based structure of the traditional diet. The convenience of eating meat, dairy products and protein supplements (such as protein powder and energy bars) makes high-protein diets popular among fitness groups and young people, but it actually leads to a sharp drop in plant fiber intake. In addition, the public generally equates high protein with high nutrition, but ignores a series of problems caused by excessive animal protein.

[0003] Excessive protein metabolism in the intestine can trigger some pathologies. For example, unabsorbed protein in the colon is fermented by microorganisms to produce ammonia, hydrogen sulfide, and indole substances, which cause foul-smelling flatulence, sticky stools, and increased pH, resulting in stool sticking to the toilet bowl. Excessive nitrogen metabolism can easily increase blood urea nitrogen levels and increase the metabolic burden on the kidneys. Current clinical interventions mainly use laxatives, probiotics, or digestive enzymes, but these only treat the symptoms and not the root cause, and are prone to dependence. Traditional Chinese medicine formulas are mostly designed for organic gastrointestinal diseases and metabolic diseases, and lack precise regulation plans for functional defecation abnormalities induced by dietary imbalance in healthy people. Therefore, there is an urgent need to develop a safe and effective Chinese medicine composition that can treat both the symptoms and the root causes, and specifically regulate abnormal stool characteristics caused by a high-protein diet. Summary of the Invention

[0004] In view of the above situation, in order to overcome the defects of the prior art, the Chinese medicine composition provided by the present invention can promote the excretion of soft stools, improve stool color, relieve stool sticking to the toilet, regulate intestinal function, and reduce flatulence odor.

[0005] In order to achieve the above-mentioned purpose, the following technical scheme is adopted: The present invention provides a traditional Chinese medicine composition for improving stool characteristics, which is prepared from the following raw materials in parts by weight: 5-30 parts of Potamogeton pectinata, 5-25 parts of Artemisia capillaris, 10-35 parts of Jerusalem artichoke, 8-30 parts of Herba Euphorbiae ibis, 3-15 parts of Licorice, and 5-20 parts of Astragalus.

[0006] Preferably, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 10-25 parts of Potamogeton ricinus, 8-20 parts of Artemisia capillaris, 15-30 parts of Jerusalem artichoke, 10-25 parts of Euphorbia milii, 5-12 parts of Licorice, and 8-18 parts of Astragalus.

[0007] Most preferably, the Chinese medicine composition is made from the following raw materials in parts by weight: 15 parts of Potamogeton ricinus, 12 parts of Artemisia capillaris, 20 parts of Jerusalem artichoke, 15 parts of Euphorbia milii, 8 parts of Licorice, and 12 parts of Astragalus.

[0008] As a further description of the above scheme: Each medicinal material of the present invention has the following effects:

[0009] Potamogeton pectinata: It promotes diuresis and eliminates dampness, clears turbidity, and promotes bowel movements. The Jingzhu Materia Medica records that it "relieves gastrointestinal stagnation." Rich in water-soluble polysaccharides and tannins, it specifically degrades the mucin MUC2 in intestinal mucus, reducing stool adhesion. Its flavonoids inhibit overexpression of aquaporins in the colonic epithelium, bidirectionally regulating stool water content.

[0010] As a further description of the above scheme: the harvest time of the Potamogeton crenata is from the end of August to the beginning of November. After harvesting, it is blanched in boiling water for one minute to remove a large amount of oxalic acid.

[0011] Artemisia capillaris: Clears heat and dampness, and dredges the liver and gallbladder. The "Shennong Bencao Jing" records that it "treats rheumatism, cold, and heat pathogens." The capillary chrysanthemum and chlorogenic acid contained in Artemisia capillaris can downregulate the TLR4 / NF-κB inflammatory pathway, inhibit the proliferation of intestinal putrefactive bacteria (such as Clostridium perfringens), and reduce the production of indole and skatole. It also promotes bile acid excretion, corrects bilirubin metabolism disorders caused by a high-protein diet, and improves the dark brown appearance of stool.

[0012] Jerusalem artichokes strengthen the spleen and stomach, promote fluid production and moisten the intestines. The "Compendium of Materia Medica in Southern Yunnan" records that they "treat spleen deficiency and water retention." Jerusalem artichokes contain inulin, which acts as a prebiotic, promoting the proliferation of bifidobacteria and lactobacilli while competitively inhibiting protein-spoilage bacteria. They also contain short-chain fatty acids, which can lower colonic pH, inhibit hydrogen sulfide synthase activity, and eliminate flatulence odors.

[0013] Herba Euphorbiae: Clears heat and detoxifies, promotes dampness and relieves dysentery. Compendium of Materia Medica states that it "treats carbuncles, ulcers, and promotes urination." Herba Euphorbiae contains quercetin and kaempferol, which activate the Nrf2 / ARE antioxidant pathway, repair goblet cells in the intestinal mucosa damaged by a high-protein diet, and enhance the physiological regulation of mucin secretion. Simultaneously, it inhibits the overgrowth of Proteobacteria and blocks mucus erosion.

[0014] Licorice: Strengthens the spleen and replenishes Qi, harmonizing various medicinal ingredients. The glycyrrhizic acid in it inhibits the 11β-HSD2 enzyme, elevating local cortisol levels and alleviating intestinal inflammation. Licorice polysaccharides enhance the expression of tight junction proteins in the intestinal epithelium, reducing endotoxin translocation and blocking immune activation triggered by undigested protein.

[0015] Astragalus: Replenishes Qi and raises Yang, strengthens the exterior and promotes diuresis. The astragaloside IV it contains promotes intestinal epithelial cell proliferation and mucus regeneration; the isoflavones it contains also enhance trypsin activity, accelerate protein breakdown and absorption, and reduce the undigested protein load in the colon.

[0016] As a further description of the above scheme: the Chinese medicine composition can be prepared into a pharmaceutically acceptable dosage form, including but not limited to any one of tablets, granules, capsules, suppositories, pills, decoctions, and oral liquids.

[0017] As a further description of the above scheme: the Chinese medicine composition also includes pharmaceutically acceptable excipients.

[0018] As a further description of the above scheme: the excipients include but are not limited to one or more of fillers, lubricants, disintegrants, suspending agents, binders and flavorings.

[0019] The beneficial effects of the present invention are as follows: the present invention significantly improves the pathological state of sticky, loose or dry stools through the dampness-clearing and turbidity-clearing effects of Potamogeton ricinus and Herba Euphorbiae rutaecarpa, promotes the discharge of formed soft stools, and relieves the phenomenon of stools sticking to the toilet; the Artemisia capillaris in the components clears away heat from the liver and gallbladder, and the Astragalus membranaceus replenishes the middle and invigorates Qi, and they jointly regulate the intestinal transportation and transformation function, so that the stool color changes from dark brown and sticky to a healthy brown-yellow; Jerusalem artichoke can regulate the balance of intestinal flora, inhibit the excessive proliferation of protein-corrupting bacteria, and reduce the generation of flatulent hydrogen sulfide and indole-type malodorous substances from the source; licorice harmonizes the various medicines and has an anti-inflammatory effect; the Astragalus membranaceus enhances the transportation and transformation capacity of the spleen and stomach, reduces the retention of undigested protein from the digestion and absorption link, and blocks the pathological basis for the generation of symptoms, and is suitable for dietary dysfunction in healthy people; the compositions provided by the present invention are all medicinal and edible or traditional non-toxic medicinal materials, and have no risk of drug dependence; they can be flexibly made into dosage forms such as tablets, granules, and oral liquids to meet the needs of different groups of people. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0021] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those familiar to those skilled in the art. Furthermore, any methods and materials similar or equivalent to those described herein can be applied to the present invention. The preferred embodiments and materials described herein are for illustrative purposes only and are not intended to limit the scope of this application.

[0022] Unless otherwise specified, the experimental methods used in the following examples are conventional methods. The experimental materials used in the following examples were all purchased from commercial sources unless otherwise specified. The Potamogeton serrata plant is harvested from late August to early November and blanched in boiling water for one minute to remove excess oxalic acid.

[0023] Example 1: A traditional Chinese medicine composition for improving stool characteristics is prepared from the following raw materials in parts by weight: 30 parts of Potamogeton ricinus, 25 parts of Artemisia capillaris, 35 parts of Jerusalem artichoke, 30 parts of Herba Euphorbiae chinensis, 15 parts of Licorice, and 20 parts of Astragalus.

[0024] Example 2: A traditional Chinese medicine composition for improving stool characteristics is prepared from the following raw materials in parts by weight: 20 parts of Potamogeton ricinus, 20 parts of Artemisia capillaris, 30 parts of Jerusalem artichoke, 25 parts of Herba Euphorbiae chinensis, 12 parts of Licorice, and 15 parts of Astragalus.

[0025] Example 3: A traditional Chinese medicine composition for improving stool characteristics is prepared from the following raw materials in parts by weight: 10 parts of Potamogeton ricinus, 8 parts of Artemisia capillaris, 15 parts of Jerusalem artichoke, 10 parts of Herba Euphorbiae chinensis, 5 parts of Licorice, and 8 parts of Astragalus.

[0026] Example 4: A traditional Chinese medicine composition for improving stool characteristics is prepared from the following raw materials in parts by weight: 12 parts of Potamogeton ricinus, 18 parts of Artemisia capillaris, 25 parts of Jerusalem artichoke, 20 parts of Herba Euphorbiae chinensis, 8 parts of Licorice, and 15 parts of Astragalus.

[0027] Example 5: A traditional Chinese medicine composition for improving stool characteristics is prepared from the following raw materials in parts by weight: 18 parts of Potamogeton ricinus, 18 parts of Artemisia capillaris, 15 parts of Jerusalem artichoke, 18 parts of Herba Euphorbiae Ibis, 7 parts of Licorice, and 10 parts of Astragalus.

[0028] Example 6: A traditional Chinese medicine composition for improving stool characteristics is prepared from the following raw materials in parts by weight: 15 parts of Potamogeton ricinus, 12 parts of Artemisia capillaris, 20 parts of Jerusalem artichoke, 15 parts of Herba Euphorbiae chinensis, 8 parts of Licorice, and 12 parts of Astragalus.

[0029] Test example: Evaluation of the effect of Chinese medicine combination

[0030] (1) Subjects: healthy adults, aged 18-50 years, half male and half female.

[0031] (2) Inclusion criteria:

[0032] No history of organic gastrointestinal disease;

[0033] Long-term high-protein diet (animal protein accounts for ≥30% of total calories);

[0034] The following symptoms persist for ≥ 1 month:

[0035] Bristol Stool Scale (BSS) type 2 (soft and mushy) or type 3 (soft stool with surface cracks);

[0036] The stool is dark brown / gray-black and sticks to the toilet bowl (subjective score ≥ 4 points).

[0037] (3) Exclusion criteria:

[0038] Organic intestinal disease, metabolic disease;

[0039] Probiotics / antidiarrheal agents / antibiotics used in the past month;

[0040] Pregnant or lactating women.

[0041] (4) Grouping: Randomized double-blind controlled trial:

[0042] Test group (n = 30): Take granules made of the formula of Example 3 of the present application;

[0043] Control group (n = 30): Placebo granules (containing only dextrin + caramel color) matching in appearance and taste;

[0044] Dose and course of treatment: 6g twice a day, taken before meals, for 4 consecutive weeks;

[0045] Diet control: Maintain the original high-protein diet pattern during the trial.

[0046] (5) Observation index and detection method: Before and after the test, the stool properties (BSS classification), stool color and toilet adhesion degree were evaluated and scored. Five fecal samples were randomly selected from each group, and the adhesion force was measured using a fecal adhesion tester. The test results are shown in Table 1.

[0047] Stool property evaluation uses the Bristol Stool Classification proposed by Heaton and Lewis in 1997, BSS classification method.

[0048] Toilet adhesion degree score is as follows:

[0049] 1 point, completely not adhered, no residue after flushing;

[0050] 2 points, slightly adhered, with a small amount of residue after flushing;

[0051] 3 points, moderate adhesion, with a small amount of residue after multiple flushing;

[0052] 4 points, a large amount of adhesion, requiring multiple flushing and manual scrubbing;

[0053] 5 points, severe adhesion, requiring multiple flushing and manual intensive scrubbing.

[0054] Table 1: Control table for evaluation of traditional Chinese medicine composition

[0055]

[0056] Analysis of the data in Table 1 shows the following conclusions: the changes in BSS classification show that the stool of the patients in the experimental group has changed to an ideal form, improving from type 2 (paste / loose) or type 3 (soft stool with cracks) before the test to type 4 (smooth banana-shaped) or type 5 (soft and easy-to-excrete lumps); the stool color of the patients in the experimental group has also changed from dark brown / gray-black to healthy yellow-brown and yellow, the adhesion score has dropped from a lot of adhesion and severe adhesion to slight adhesion, and the adhesion force value has also been greatly reduced, while there was no change in the control group. This shows that the Chinese medicine composition provided by the present invention can significantly improve the pathological state of sticky and loose stools or dry and uneven stools, promote the discharge of formed soft stools, and alleviate the phenomenon of stool sticking to the toilet, which has clinical application significance.

[0057] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

[0058] The above description of the present invention and its embodiments is non-limiting and only illustrates one embodiment of the present invention. The actual application is not limited thereto. In short, if a person skilled in the art is inspired by the above description and, without departing from the purpose of the present invention, devises methods and embodiments similar to the technical solution without inventiveness, they shall fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for improving stool characteristics, characterized in that: The invention is prepared from the following raw materials in parts by weight: 5-30 parts of Potamogeton ricinus, 5-25 parts of Artemisia capillaris, 10-35 parts of Jerusalem artichoke, 8-30 parts of Euphorbia milii, 3-15 parts of Licorice root and 5-20 parts of Astragalus root.

2. A Chinese medicine composition for improving stool characteristics according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 10-25 parts of Potamogeton ricinus, 8-20 parts of Artemisia capillaris, 15-30 parts of Jerusalem artichoke, 10-25 parts of Euphorbia milii, 5-12 parts of Licorice root and 8-18 parts of Astragalus root.

3. A Chinese medicine composition for improving stool characteristics according to claim 2, characterized in that: The invention is prepared from the following raw materials in parts by weight: 15 parts of Potamogeton ricinus, 12 parts of Artemisia capillaris, 20 parts of Jerusalem artichoke, 15 parts of Euphorbia milii, 8 parts of Licorice root and 12 parts of Astragalus root.

4. A Chinese medicine composition for improving stool characteristics according to any one of claims 1 to 3, characterized in that: The harvesting time of the Potamogeton pectinata is from the end of August to the beginning of November. After harvesting, the Potamogeton pectinata is blanched in boiling water for one minute to remove a large amount of oxalic acid.

5. A Chinese medicine composition for improving stool characteristics according to claim 4, characterized in that: The Chinese medicine composition can be prepared into pharmaceutically acceptable dosage forms, including but not limited to any one of tablets, granules, capsules, suppositories, pills, decoctions, and oral liquids.

6. A Chinese medicine composition for improving stool characteristics according to claim 4, characterized in that: The traditional Chinese medicine composition also includes pharmaceutically acceptable excipients.

7. A Chinese medicine composition for improving stool characteristics according to claim 4, characterized in that: The excipients include, but are not limited to, one or more of fillers, lubricants, disintegrants, suspending agents, binders and flavoring agents.

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