Microneedle administration device for animal experiment

Abstract

The invention discloses a microneedle administration device for animal experiments. The microneedle administration device mainly solves the problems that in the prior art, a microneedle patch is prone to falling off, and administration pressure control is inaccurate. The device comprises a disc-shaped body, a medical fixing adhesive tape, a microneedle patch, a telescopic air bag and other core components. Safe storage and accurate ejection of the microneedle are achieved through contraction and inflation of the air bag, and the device can be matched with various microneedle types in combination with a replaceable annular light source system. The device adopts an integrated design, integrates pressure control, illumination adjustment and data display functions, can automatically adapt to different animal skin characteristics, and ensures the consistency of administration dosage. Compared with a traditional scheme, the reliability and accuracy of microneedle administration in animal experiments are remarkably improved, and a professional experimental tool is provided for research and development of a microneedle technology.

Description

Technical Field

[0001] The present invention relates to an animal experiment device, in particular to a microneedle drug delivery device for animal experiments. Background Art

[0002] Microneedle patch technology, a significant breakthrough in modern drug delivery, is transforming traditional injection and oral drug delivery methods. This innovative device, resembling a Band-Aid, features a dense surface of micron-sized needles and drug storage structures, enabling painless penetration through the skin's stratum corneum for precise drug delivery. Currently, a variety of microneedle products have been developed on the market, including soluble microneedles that rely on the solubility properties of the material, coated microneedles with drugs coated on the surface, and intelligent microneedle systems that respond to external stimuli such as light, heat, and magnetism. These technologies demonstrate unique advantages in areas such as vaccine delivery and chronic disease treatment, and related clinical research is rapidly advancing globally.

[0003] In the research and development chain of microneedle technology, animal experiments are an indispensable key link. However, researchers face many special challenges in practice. The activity characteristics of experimental animals such as mice make traditional fixation methods difficult to work. They will cause the microneedle patches to fall off or shift by biting each other, strenuous exercise, etc. There are significant differences in the thickness and elasticity of the skin of different strains of experimental animals, which puts higher requirements on the control of the penetration depth of microneedles. Existing clinical microneedle drug delivery devices are mainly designed for flat parts such as the back and arms of the human body, and cannot adapt to the special anatomical structure of small experimental animals such as mice. In response to these practical problems, the development of dedicated animal experimental microneedle drug delivery devices is particularly urgent. Summary of the Invention

[0004] In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is.

[0005] To achieve the above objectives, the present invention provides a microneedle drug delivery device for animal experiments, comprising:

[0006] The disc-shaped body consists of an upper cover and a lower cover;

[0007] Medical tape provided on the side of the body;

[0008] A microneedle patch disposed within the body;

[0009] The lower cover is provided with a window corresponding to the microneedle surface of the microneedle patch;

[0010] a stretchable airbag, the bottom of which is attached to the back of the microneedle patch;

[0011] When the telescopic airbag is deflated, the microneedles of the microneedle patch are located inside the lower cover;

[0012] When the telescopic airbag is inflated, the microneedles of the microneedle patch are pushed out of the window.

[0013] Furthermore, it also includes: a micro air pump and a battery arranged in the main body, which are used to inflate the telescopic airbag; or an inflation hole arranged on the upper cover, which is used for an external air source to inflate the telescopic airbag.

[0014] Furthermore, it also includes: an annular light strip arranged on the inner side of the lower cover; a light-guiding pressure plate arranged above the annular light strip, the upper surface of which is reflective and the side is fixedly connected to the annular light strip; and the telescopic airbag is made of a light-transmitting material.

[0015] Furthermore, the annular light strip is a replaceable light strip, and an 830nm infrared light strip or a 415nm blue light strip can be installed.

[0016] Furthermore, it also includes: a display screen arranged on the upper cover, which is used to display the airbag pressure, working time and lighting time parameters.

[0017] Furthermore, it also includes: a temperature measuring contact is provided on the lower cover for detecting the body temperature of the animal.

[0018] Furthermore, the telescopic airbag can automatically adapt to the height difference of the animal's skin when inflated, forming a consistent pressure on the microneedle patch, so that the depth of the microneedles penetrating the skin remains consistent.

[0019] Furthermore, the microneedle patch is any one of soluble microneedles, coated microneedles or responsive microneedles.

[0020] The present invention also discloses a method for using any of the above-mentioned microneedle drug delivery devices, comprising the following steps:

[0021] Fix the device to the skin surface of the experimental animal using medical tape;

[0022] Inflate the telescopic airbag through a micro air pump or an inflation hole;

[0023] The microneedle patch is pushed out from the window and penetrates the animal skin for drug administration.

[0024] Furthermore, it also includes: providing light stimulation of a specific spectrum to the responsive microneedles through an annular light strip; and monitoring and adjusting drug delivery parameters through a display screen.

[0025] The microneedle drug delivery device provided by the present invention significantly improves the drug delivery effect in animal experiments through innovative design. The device uses medical tape to fix the disc-shaped main body structure to ensure that it is firmly attached to the surface of the experimental animal and effectively prevent the microneedles from falling off. The pressure control system of the retractable airbag can accurately adjust the penetration depth of the microneedles to adapt to the skin characteristics of different animals and ensure the consistency of the drug delivery dose. The integrated light control system supports a variety of responsive microneedle requirements, and the replaceable light source design meets different experimental conditions. The upper cover display screen realizes real-time parameter monitoring and simplifies the operation process. The device combines microneedle storage protection with precise drug delivery functions, which not only ensures operational safety but also improves experimental efficiency. The integrated design is easy to use, and the built-in monitoring system records key data, providing a reliable basis for research and analysis. The device solves the problems of unstable microneedle fixation and insufficient drug delivery accuracy in traditional animal experiments, and provides a professional and reliable experimental tool for the research and development of microneedle technology.

[0026] The concept, specific structure and technical effects of the present invention will be further described below in conjunction with the accompanying drawings to fully understand the purpose, characteristics and effects of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a top view of the microneedle drug delivery device for animal experiments of the present invention;

[0028] Figure 2 yes Figure 1 A bottom view of the microneedle drug delivery device before drug delivery;

[0029] Figure 3 yes Figure 1 A view of the microneedle drug delivery device with the upper and lower covers removed;

[0030] Figure 4 yes Figure 1 Internal view of the microneedle drug delivery device after opening the top cover;

[0031] Figure 5 This is an exploded view of the microneedle drug delivery device;

[0032] Figure 6 This is a view from the bottom of the microneedle drug delivery device during drug delivery. DETAILED DESCRIPTION

[0033] The following describes several preferred embodiments of the present invention with reference to the accompanying drawings to make its technical content clearer and easier to understand. The present invention can be embodied in many different forms of embodiments, and the scope of protection of the present invention is not limited to the embodiments mentioned herein.

[0034] In the drawings, components with identical structures are denoted by the same reference numerals, and components with similar structures or functions are denoted by similar reference numerals. The size and thickness of each component shown in the drawings are arbitrary and are not limited by the present invention. For clarity, the thickness of components in some places in the drawings is appropriately exaggerated.

[0035] like Figure 1-2 As shown, the microneedle drug delivery device for animal testing of the present invention comprises a disc-shaped body comprising an upper cover 2 and a lower cover 4. Medical tape 1 is fixedly attached to the outer periphery of the side of the body. A microneedle patch 6 is disposed within the body. Lower cover 4 has a window 5 at a position corresponding to the microneedle surface of microneedle patch 6.

[0036] like Figure 3-6 As shown, the back side of the microneedle surface of the microneedle patch 6 is attached to the bottom of the telescopic airbag 8. When the telescopic airbag 8 is in a contracted state, the microneedles of the microneedle patch 6 are located inside the lower cover 4. When the telescopic airbag 8 is inflated, the microneedle patch 6 is pushed out of the window 5 by the telescopic airbag 8. In some embodiments, a micro air pump 9 and a battery 10 are also provided in the body for inflating the telescopic airbag 8. In other embodiments, the telescopic airbag 8 can also be inflated by means provided on the upper cover 2. When in use, the device is first attached to the skin surface of an experimental animal such as a mouse through medical tape, and then the telescopic airbag 8 is inflated through the micro air pump 9 or the inflation hole 14, so that the microneedle patch 6 is pushed out from the window 5 and penetrates the animal's skin for drug administration. In this way, on the one hand, the microneedles are stored in the lower cover 4 in the initial state, which is safer for the operator, and it is also easier to fix the device and the experimental animal with medical tape. On the other hand, since the telescopic airbag 8 and the microneedle patch 6 are both soft, when the microneedle patch 6 penetrates the animal skin, it can automatically adapt to the height difference of the animal skin, thereby sticking to the animal skin and forming a consistent pressure on the microneedle patch, so that the depth of microneedle penetration into the skin remains consistent, meeting the stability and effectiveness requirements of subsequent drug administration, and ensuring the consistency of experimental results.

[0037] In a further embodiment, an annular light strip 14 is further provided on the inner side of the lower cover 4. A light-guiding pressure plate 11 is provided above the annular light strip 14. The upper surface of the light-guiding pressure plate 11 is reflective, and its circular side is fixedly connected to the annular light strip 14, which can form side light and emit light uniformly downward. At the same time, the telescopic airbag 8 is also configured to be made of a light-transmitting material, thereby providing specific needs such as light and heat for the microneedles below. In the embodiment shown in the figure, the micro air pump 9 or the inflation hole 14 is provided above the light-guiding pressure plate 11, and the air pipe 12 of the micro air pump 9 passes through the central opening 13 of the light-guiding pressure plate 11 and passes into the transparent telescopic airbag 8 located below the light-guiding pressure plate 11.

[0038] In a further embodiment, a display screen 3 is further provided on the upper cover 2 for displaying control parameters such as airbag pressure, working time, light exposure time, etc. A temperature measuring contact 7 is provided on the lower cover 4 for detecting the body temperature of the animal.

[0039] The above describes in detail the preferred embodiments of the present invention. It should be understood that those skilled in the art can make numerous modifications and variations based on the concepts of the present invention without inventive effort. Therefore, any technical solutions that can be derived by those skilled in the art through logical analysis, reasoning, or limited experimentation based on the concepts of the present invention and the prior art should be within the scope of protection defined by the claims.

Claims

1. A microneedle drug delivery device for animal experiments, characterized in that: include: The disc-shaped body is composed of an upper cover (2) and a lower cover (4); A medical tape (1) is provided on the side of the body; A microneedle patch (6) disposed in the body; The lower cover (4) is provided with a window (5) corresponding to the microneedle surface of the microneedle patch (6); a telescopic airbag (8), the bottom of which is attached to the back of the microneedle patch (6); When the telescopic airbag (8) contracts, the microneedles of the microneedle patch (6) are located inside the lower cover (4); When the telescopic airbag (8) is inflated, the microneedles of the microneedle patch (6) are pushed out of the window (5).

2. The microneedle drug delivery device according to claim 1, wherein Also includes: A micro air pump (9) and a battery (10) arranged in the main body are used to inflate the telescopic airbag (8); or an inflation hole (14) arranged on the upper cover (2) is used to inflate the telescopic airbag (8) with an external air source.

3. The microneedle drug delivery device according to claim 1, wherein Also includes: An annular light strip (14) is arranged on the inner side of the lower cover (4); a light guide pressure plate (11) is arranged above the annular light strip (14), its upper surface is reflective, and its side is fixedly connected to the annular light strip (14); and the telescopic airbag (8) is made of a light-transmitting material.

4. The microneedle drug delivery device according to claim 3, wherein: The annular light strip (14) is a replaceable light strip, and an 830nm infrared light strip or a 415nm blue light strip can be installed.

5. The microneedle drug delivery device according to claim 1, wherein: Also includes: A display screen (3) provided on the upper cover (2) is used to display airbag pressure, working time and illumination time parameters.

6. The microneedle drug delivery device according to claim 1, wherein: Also includes: A temperature measuring contact (7) is provided on the lower cover (4) for detecting the body temperature of the animal.

7. The microneedle drug delivery device according to claim 1, wherein: The telescopic airbag (8) can automatically adapt to the height difference of the animal's skin when inflated, and form a consistent pressure on the microneedle patch (6), so that the depth of the microneedles penetrating the skin remains consistent.

8. The microneedle drug delivery device according to claim 1, wherein: The microneedle patch (6) is any one of soluble microneedles, coated microneedles or responsive microneedles.

9. The method for using the microneedle drug delivery device according to any one of claims 1 to 8, characterized in that: The following steps are involved: The device is fixed to the skin surface of the experimental animal by medical tape (1); Inflate the telescopic airbag (8) through the micro air pump (9) or the inflation hole (14); The microneedle patch (6) is pushed out from the window (5) and penetrates into the animal skin to administer the drug.

10. The method of use according to claim 9, characterized in that: Also includes: A ring light strip (14) is used to provide light stimulation of a specific spectrum to the responsive microneedles; The drug delivery parameters are monitored and adjusted via the display screen (3).

Images