Implantable multifunctional arterial perfusion chemotherapy device and intelligent adjusting system

Abstract

The invention aims at providing an implantable multifunctional arterial perfusion chemotherapy device and an intelligent adjusting system, and relates to the technical field of medical instruments, through cooperation of a double-port body structure and a plurality of balloon devices, the position of a catheter can be effectively fixed, displacement of the catheter is avoided, and the accuracy of drug delivery is ensured; the intelligent control system accurately adjusts the blood flow rate, the balloon inflation degree and the like, it is ensured that medicine can be evenly and effectively distributed to a tumor area, the medicine effect is maximized, and damage to healthy tissue is reduced; side effects such as medicine leakage and vascular injury are reduced, and the treatment safety is ensured; the external control terminal provides a simple and convenient operation platform for a doctor, helps the doctor to make treatment adjustment through real-time data feedback, and reduces the operation complexity in the treatment process; and the intelligent system automatically generates a personalized treatment scheme according to the physiological reaction of the patient, so that each patient can obtain the most suitable treatment scheme, and the treatment accuracy is further improved.

Description

Technical Field

[0001] The present invention relates to the technical field related to medical devices, and in particular to an implantable multifunctional arterial perfusion chemotherapy device and an intelligent regulation system. Background Art

[0002] Intra-arterial chemotherapy (IAC) is a targeted local therapy that achieves precise tumor treatment by directly injecting high concentrations of chemotherapy drugs into the tumor's blood supply artery. However, existing arterial infusion devices still have many technical difficulties and application bottlenecks, mainly manifested in the following aspects:

[0003] 1. Inaccurate blood flow control: Existing arterial perfusion devices have difficulty accurately regulating blood flow velocity and drug delivery volume, resulting in inaccurate drug delivery to the tumor area. This leads to low drug penetration efficiency, increased side effects, and reduced therapeutic efficacy.

[0004] 2. Poor device stability and distal catheter displacement: The catheter and balloon fixation devices in traditional arterial perfusion devices often have poor stability. Currently, although some balloon fixation devices can provide a certain degree of stability, due to the imprecise control of balloon inflation, the fixation effect is often affected by local blood pressure and cannot guarantee stability in all situations.

[0005] 3. High operational complexity and difficulty adapting to individual differences: Existing devices often lack sufficient adaptive adjustment capabilities to account for the differences in arterial anatomy between patients, making it difficult to precisely adjust to individual differences. Furthermore, during treatment, catheter insertion and drug delivery often require multiple steps, which can easily lead to cumbersome operations or treatment delays.

[0006] 4. Drug concentration detection and feedback regulation: The effectiveness of intra-arterial chemotherapy relies on precise control of drug concentration. However, traditional devices lack real-time drug concentration monitoring and feedback regulation mechanisms. Manual adjustments are prone to inaccurate and untimely adjustments, resulting in drug concentrations in the tumor area failing to reach the desired target, which not only affects treatment efficacy but also increases the risk of drug toxicity and side effects. Summary of the Invention

[0007] In view of the shortcomings of the prior art, the present invention provides the following technical solutions:

[0008] A multifunctional arterial perfusion chemotherapy device comprises a double-port body, a main catheter, a balloon device, and a control terminal; the balloon device is mounted on the outer wall of the main catheter, and the double-port body is mounted on the tail end of the main catheter; two delivery channels are provided inside the main catheter, one delivery channel connects the double-port body and the head end of the main catheter, and the other delivery channel connects the double-port body and the balloon device; the balloon device comprises at least one airbag.

[0009] Furthermore, the balloon device is composed of a single airbag, which is fixedly connected to the main catheter.

[0010] Furthermore, the balloon device is composed of a plurality of airbags, which are fixedly arranged at intervals on the side wall of the main catheter.

[0011] Furthermore, the airbag is not coaxial with the main catheter, and the plurality of airbags on the main catheter are installed on the same side or cross-installed on both sides.

[0012] Furthermore, the portion of the main catheter near the head end is plastic, and the two delivery channels in the main catheter are of different thicknesses. The thin delivery channel connects the double-port body and the balloon device; the double-port body includes two infusion ports, which are integrally formed or exist separately.

[0013] Furthermore, the control terminal includes a body, an infusion bottle is provided in the body, an infusion pump is detachably provided on the infusion bottle, the infusion bottle is connected to the double port body through the infusion pump; an air pump is provided in the body and is connected to the double port body.

[0014] A multifunctional intelligent regulation system for arterial chemotherapy infusion includes a monitoring module disposed at the tip of a main catheter and a control module disposed on the body; the monitoring module is used to detect intravascular pressure, blood flow rate, and temperature of the infusion area; the control module is used to adjust the power of the infusion pump and air pump and receive signals from the monitoring module;

[0015] The monitoring module detects the pressure in the blood vessels, the blood flow rate, and the temperature of the perfusion area, and transmits the data to the control module in real time; the control module compares the detected data with the input pressure and flow rate, and controls the power of the infusion pump and air pump to make the pressure and flow rate reach the input values.

[0016] Furthermore, the monitoring module includes a pressure detection unit, a flow detection unit, a temperature detection unit, and a connection unit;

[0017] The pressure detection unit is used to detect pressure changes in blood vessels;

[0018] The flow detection unit is used to detect the change in blood flow rate in the blood vessels;

[0019] The temperature detection unit is used to detect the temperature change of the perfusion area in the blood vessel;

[0020] The connection unit is used to transmit signals to connect with the control module and transmit data;

[0021] Furthermore, the control module includes an input unit, and the input unit is used to input instructions.

[0022] Compared with the existing technology, the technical solution of this application has the following beneficial effects:

[0023] 1. Precision Control: The intelligent control system precisely adjusts blood flow rate, balloon inflation level, and other parameters to ensure that the drug is evenly and effectively distributed to the tumor area, maximizing drug efficacy and minimizing damage to healthy tissue. The system monitors and provides real-time feedback on changes in blood flow, drug concentration, and temperature, automatically adjusting treatment parameters to achieve precision and personalization of the treatment process and maximize treatment efficacy. The intelligent control system automatically adjusts drug delivery volume, blood flow rate, and balloon inflation level to minimize side effects such as drug leakage and vascular damage, ensuring treatment safety.

[0024] 2. Stable catheter fixation: The combination of the double port body and multiple airbag devices can effectively fix the catheter position, prevent catheter displacement, and ensure the accuracy of drug delivery;

[0025] 3. Simplify operations and improve treatment effects: The control terminal provides doctors with a simple operation platform, helping doctors make treatment adjustments through real-time data feedback, and reducing the operational complexity during the treatment process. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0027] Figure 2 This is a schematic diagram of the internal structure of the main conduit of the present invention;

[0028] Figure 3 Schematic diagram of a single airbag of the present invention.

[0029] In the figure: control terminal-1, display screen-11, control module-2, infusion bottle-3, infusion pump-4, air pump-5, connecting tube-6, puncture needle-7, double port body-8, main tube-9, delivery channel-91, air bag-92, monitoring module-93. DETAILED DESCRIPTION

[0030] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0031] Example 1:

[0032] See also Figure 1-3 A multifunctional arterial perfusion chemotherapy device includes a double port body 8, a main catheter 9, a balloon device, and a control terminal 1; the balloon device is installed on the outer wall of the main catheter 9, and the double port body 8 is installed on the tail end of the main catheter 9;

[0033] In this embodiment, the dual-port body 8 is embedded subcutaneously to secure the device and provide stability against high pressure and repeated punctures. The dual-port body 8 includes two infusion ports, which can be integrated or separate. The shape of the ports can be customized based on the patient's anatomical differences. The dual-port body 8 structure effectively secures the catheter, preventing deviation in drug delivery due to catheter displacement, and ensuring precise drug delivery to the target area.

[0034] In this embodiment, the portion of the main catheter 9 near the tip is plastic, made of thermoplastic polymer material or memory alloy, so that the main catheter 9 can be changed into different shapes according to actual conditions. Two delivery channels 91 are provided inside the main catheter 9. The two delivery channels 91 are of different thicknesses. The thin delivery channel 91 connects the double port 8 and the balloon device, controlling the balloon device to regulate the blood flow rate in the blood vessel; the thick delivery channel 91 connects the double port 8 and the tip of the main catheter 9, and is used to deliver chemotherapy drugs to the tumor blood supply artery.

[0035] In this embodiment, the balloon device includes at least one airbag 92; when the balloon device is composed of a single airbag 92, the airbag 92 is fixedly connected to the main catheter 9;

[0036] When the balloon device is composed of multiple balloons 92, the balloons 92 are fixedly arranged at intervals on the side wall of the main catheter 9. The balloons 92 are not coaxial with the main catheter 9, and the balloons 92 on the main catheter 9 are installed on the same side or cross-mounted on both sides. The degree of inflation of the balloons 92 can adjust the blood flow rate in the blood vessels. The balloons 92 are kept at least 2-3 cm apart to ensure the stability of the main catheter 9 and optimize blood flow control. The balloons 92 not only facilitate drug penetration in the tumor area, but also help stabilize the position of the main catheter 9, preventing displacement of the main catheter 9 and uneven blood flow.

[0037] In this embodiment, the control terminal 1 includes a body, in which an infusion bottle 3 is provided, and an infusion pump 4 is detachably provided on the infusion bottle 3. The infusion bottle 3 is connected to the double port body 8 through the infusion pump 4; an air pump 5 is provided in the body and is connected to the double port body 8; the infusion pump 4 and the air pump 5 are both connected to a puncture needle 7 through a connecting tube 6. The puncture needle 7 is used to insert into the infusion port during treatment to form a channel. The puncture needle 7 penetrates the blood vessel through the skin and enters the port body to ensure that the drug can enter the main catheter 9.

[0038] Example 2:

[0039] See also Figure 1-3 According to Example 1, a multifunctional intelligent regulation system for arterial chemotherapy perfusion includes a monitoring module 93 disposed at the tip of a main catheter 9 and a control module 2 disposed on the body; the monitoring module 93 is used to detect intravascular pressure, blood flow rate, and temperature of the perfusion area; the control module 2 is used to adjust the power of the infusion pump 4 and the air pump 5 and receive signals from the monitoring module 93; the monitoring module 93 includes a pressure detection unit, a flow detection unit, a temperature detection unit, and a connection unit;

[0040] The pressure detection unit is used to detect pressure changes in blood vessels;

[0041] The flow detection unit is used to detect the change in blood flow rate in the blood vessels;

[0042] The temperature detection unit is used to detect the temperature change of the perfusion area in the blood vessel;

[0043] The connection unit is used to transmit signals to connect with the control module 2 and transmit data;

[0044] The control module 2 includes an input unit, which is used to input instructions;

[0045] In this embodiment, the monitoring module 93 detects intravascular pressure, blood flow rate, and temperature of the perfusion area, and transmits the data in real time to the control module 2. The control module 2 compares the detected data with the input pressure, flow rate, and temperature. If the intravascular pressure is higher than a predetermined value, the air pump 5 is controlled to evacuate air, causing the airbag 92 to contract to a certain degree to balance the intravascular pressure. Otherwise, the air pump 5 is controlled to inflate air, causing the airbag 92 to expand to a certain degree to maintain blood flow stability. If the blood flow rate is lower than a predetermined value, the air pump 5 is controlled to evacuate air, causing the airbag 92 to contract to a certain degree to accelerate blood flow. Similarly, if the blood flow rate is higher than a predetermined value, the flow rate can be reduced to ensure uniform distribution of the drug. Based on the temperature comparison, the flow rate of the liquid delivered by the infusion pump 4 can be controlled to adjust the temperature of the perfusion area to prevent excessively high or low temperatures from damaging tissues. The temperature sensor can sense temperature changes in real time during treatment to prevent temperature fluctuations from adversely affecting normal tissues. The doctor can operate the intelligent adjustment system through the control module 2 of the control terminal 1 to make real-time adjustments. The operating interface is simple and intuitive, allowing medical personnel to manually or automatically adjust treatment parameters (such as blood flow velocity, drug delivery volume, balloon inflation volume, etc.) to respond to the patient's physiological changes during treatment.

[0046] Example 3:

[0047] See also Figure 1-3 , according to Example 1-2:

[0048] Treatment process: The doctor inserts the puncture needle 7 into the patient's double port 8, which is then connected to the infusion pump 4 and the air pump 5 via the connecting tube 6. The intelligent regulation system automatically adjusts treatment parameters, such as balloon inflation volume, drug delivery volume, and blood flow velocity, by monitoring blood flow status and perfusion area temperature data in real time, or the doctor manually adjusts them to ensure that the drug precisely enters the tumor area.

[0049] Operation method: The doctor inputs parameters through the control terminal 1 and connects the puncture needle 7, main catheter 9 and monitoring module 93 to start treatment; the system adjusts the treatment parameters according to real-time feedback data to ensure accurate drug delivery and maintain stable blood flow; after the treatment, the doctor continues to monitor or adjust the treatment plan as needed; the accuracy and stability of the treatment process are ensured, and through automated adjustment and real-time monitoring, arterial infusion chemotherapy is safer and more efficient.

[0050] Example 4:

[0051] According to Examples 1-3, this example is the application of arterial perfusion chemotherapy for different types of tumors; exploring the effects in the treatment of different tumors, based on the biological characteristics of different tumors, blood supply conditions and individual differences of patients, this example demonstrates the various adaptabilities and therapeutic effects of the device.

[0052] (1) Arterial infusion chemotherapy for breast cancer: In the treatment of breast cancer, puncture is usually performed through the subclavian artery, femoral artery, or brachial artery to enter the breast-related artery to accurately deliver chemotherapy drugs to the breast tumor area. Because breast cancer has a good vascular supply, arterial infusion chemotherapy can effectively increase the concentration of drugs in tumor tissue while preventing drug extravasation into normal tissues;

[0053] Implementation details: The Dual Harbor 8 is implanted subcutaneously in the patient. Through puncture of the subclavian or femoral artery, a drug catheter precisely delivers the drug to the artery supplying the breast tumor. Inflation of the balloon regulates blood flow, ensuring efficient drug penetration into the tumor tissue. Based on the blood flow characteristics of breast cancer, the device adjusts blood flow velocity and drug delivery volume in real time to optimize drug accumulation in the tumor area.

[0054] Therapeutic effect: In the treatment of breast cancer patients, the arterial infusion chemotherapy device can precisely control the drug concentration so that the drug can achieve the maximum effect in the tumor area while reducing side effects on the breast and surrounding normal tissues.

[0055] (2) Arterial infusion chemotherapy for liver cancer: Liver cancer has a complex blood supply network, and arterial infusion chemotherapy is particularly important for the treatment of liver cancer. Through femoral artery or radial artery puncture, chemotherapy drugs can be directly delivered to the liver tumor blood supply artery area, and at the same time, blood flow regulation can be used to enhance the drug retention time in the tumor tissue;

[0056] Implementation details: Dual-port device 8: Punctured via the femoral, radial, or cubital arteries, the main catheter 9 precisely delivers drugs to the liver tumor's blood supply artery. Inflation of the balloon device regulates blood flow velocity, prolonging drug residence time in the tumor area and optimizing drug distribution. Real-time monitoring of blood flow and drug delivery volume allows for dynamic adjustment of drug delivery volume and flow rate to address the liver's unique blood flow conditions.

[0057] Therapeutic effect: The arterial infusion chemotherapy device improves the penetration efficiency of drugs in liver tumors and reduces damage to healthy liver by precisely controlling drug delivery and blood flow rate, significantly improving the therapeutic effect.

[0058] (3) Arterial infusion chemotherapy for lung cancer: The blood supply of lung cancer tumors is heterogeneous. Arterial infusion chemotherapy can precisely treat the blood supply characteristics of different lung tumors. This embodiment uses bronchial artery infusion chemotherapy to optimize the distribution of drugs in lung tissue by precisely controlling the delivery of drugs to the tumor blood supply area.

[0059] Implementation details: The dual-port device 8 is inserted through the femoral or radial artery to deliver the main catheter 9 into the bronchial artery system. By adjusting the inflation level of the balloon device, the pulmonary artery blood flow velocity is regulated to optimize drug delivery to the tumor area. Based on real-time blood flow data, drug concentration, and temperature changes, blood flow and drug delivery volume are automatically adjusted to meet the special needs of lung tumors.

[0060] Therapeutic effect: Through an intelligent control system, the arterial infusion chemotherapy device can optimize the distribution of drugs in lung tumors, increase the accumulation concentration of drugs, and reduce the side effects of drugs on healthy lung tissue, thereby improving the therapeutic effect;

[0061] The present application can also be used for arterial infusion chemotherapy of pancreatic cancer, arterial infusion chemotherapy of gastric cancer, arterial infusion chemotherapy of head and neck tumors, arterial infusion chemotherapy of urinary system tumors, arterial infusion chemotherapy of gynecological tumors, and arterial infusion chemotherapy of bone malignancies.

[0062] The preferred embodiments of the present invention disclosed above are intended only to help illustrate the present invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the present invention to the specific embodiments described. Obviously, many modifications and variations are possible based on the content of this specification. These embodiments are selected and described in detail in this specification to better explain the principles and practical applications of the present invention, thereby enabling those skilled in the art to better understand and utilize the present invention. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. An implantable multifunctional arterial infusion chemotherapy device, comprising a double port, a main catheter, a balloon device, and a control terminal, characterized in that: The balloon device is installed on the outer wall of the main catheter, and the double port body is installed on the tail end of the main catheter; two delivery channels are provided inside the main catheter, one delivery channel connects the double port body and the head end of the main catheter, and the other delivery channel connects the double port body and the balloon device; the balloon device includes at least one airbag.

2. The implantable multifunctional arterial infusion chemotherapy device according to claim 1, characterized in that: The balloon device consists of a single airbag, which is fixedly connected to the main catheter.

3. The implantable multifunctional arterial infusion chemotherapy device according to claim 1, characterized in that: The balloon device is composed of a plurality of air bags, which are fixedly arranged at intervals on the side wall of the main catheter.

4. The implantable multifunctional arterial infusion chemotherapy device according to claim 3, characterized in that: The airbag is not coaxial with the main conduit, and the plurality of airbags on the main conduit are installed on the same side or cross-installed on both sides.

5. The implantable multifunctional arterial infusion chemotherapy device according to claim 1, characterized in that: The portion of the main catheter near the head end is plastic, and the two delivery channels in the main catheter are of different thicknesses. The thin delivery channel connects the double port body and the balloon device; the double port body includes two infusion ports, which are integrally formed or exist separately.

6. The implantable multifunctional arterial infusion chemotherapy device according to claim 1, characterized in that: The control terminal includes a body, an infusion bottle is arranged in the body, an infusion pump is detachably arranged on the infusion bottle, and the infusion bottle is connected to the double port body through the infusion pump; an air pump is arranged in the body and is connected to the double port body.

7. A multifunctional intelligent regulation system for arterial chemotherapy infusion, comprising a monitoring module mounted on the tip of a main catheter and a control module mounted on the body; the monitoring module is used to detect intravascular pressure, blood flow rate, and temperature in the infusion area; the control module is used to adjust the power of the infusion pump and air pump and receive signals from the monitoring module; The monitoring module detects the pressure in the blood vessels, the blood flow rate, and the temperature of the perfusion area, and transmits the data to the control module in real time; the control module compares the detected data with the input pressure and flow rate, and controls the power of the infusion pump and air pump to make the pressure and flow rate reach the input values.

8. The multifunctional arterial perfusion chemotherapy intelligent regulation system according to claim 7, characterized in that: The monitoring module includes a pressure detection unit, a flow detection unit, a temperature detection unit, and a connection unit; The pressure detection unit is used to detect pressure changes in blood vessels; The flow detection unit is used to detect the change in blood flow rate in the blood vessels; The temperature detection unit is used to detect the temperature change of the perfusion area in the blood vessel; The connection unit is used to transmit signals to connect with the control module and transmit data; The control module includes an input unit, and the input unit is used to input instructions.

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