Green grass paste containing composite cold extraction extract and preparation method of green grass paste

Abstract

Traditional Chinese medicine ingredients of traditional grass paste are prepared by adopting a high-temperature extraction process, and heat-sensitive active ingredients (such as alkannin and acetylshikonin) in medicinal materials such as lithospermum erythrorhizon are easily damaged at high temperature, so that the anti-inflammatory and soothing effects of the traditional grass paste are reduced. Therefore, a novel green grass paste preparation process capable of retaining active ingredients of medicinal materials to the greatest extent is to be developed urgently. The invention aims to overcome the defects of the prior art, and provides the green grass paste of the compound cold extraction extract with remarkably improved efficacy and low irritation and the preparation method thereof. The raw materials are all local characteristic plant resources in Hainan, and accord with the guidance of the value-added policy of Hainan self-trade port processing. Effective components of the radix arnebiae are extracted through a cold extraction method, high-temperature damage is avoided, and active substances are reserved to the maximum extent. Animal experiments and human body trials prove that the fading time for redness, swelling and pruritus caused by mosquito bites is shortened by about 50% compared with that of a traditional product after the green grass paste is compounded with the green grass paste matrix, and the allergy rate is remarkably reduced.

Description

Detailed Implementation

[0001] Preparation of cold-extracted Lithospermum root extract: Take 50g of dried Lithospermum root, pulverize it through an 80-mesh sieve, and place it together with 500mL of virgin coconut oil from Wenchang, Hainan in a brown glass bottle. Incubate at 25℃ in the dark for 48 hours, shaking once every 12 hours. Then centrifuge at 3000 rpm for 10 minutes, collect the supernatant, and filter it through a 0.45μm organic filter membrane to obtain the cold-extracted Lithospermum root extract.

[0002] Preparation of Artemisia argyi cold extract: Take 50g of dried Artemisia argyi leaves, pulverize them through a 60-mesh sieve, and place them together with 500mL of Hainan Wenchang virgin coconut oil in a brown glass bottle. Incubate at 28℃ in the dark for 36 hours, shaking once every 8 hours. Then centrifuge at 2800 rpm for 12 minutes, collect the supernatant, and filter it through a 0.45μm organic filter membrane to obtain the Artemisia argyi cold extract.

[0003] Preparation of compound herbal extract: Take 940g of conventional herbal extract base and heat it to 70℃ to melt it. While stirring, slowly add 30g of cold-extracted purple gromwell root extract and 30g of cold-extracted artemisia argyi extract (i.e., the total amount of compound extracts added is 6%, in a 1:1 ratio), and continue stirring for 20 minutes to mix it evenly. Then fill it into bottles at 55℃ and let it cool naturally to room temperature to obtain the final product. Background Technology

[0004] Traditional herbal ointments often employ high-temperature extraction processes to prepare medicinal ingredients. However, high temperatures can easily destroy heat-sensitive active components (such as shikonin and acetylshikonin) in herbs like Lithospermum erythrorhizon, leading to a reduction in their anti-inflammatory and soothing effects. Therefore, there is an urgent need to develop a new process for preparing herbal ointments that can maximize the preservation of the active ingredients in the herbs. Summary of the Invention

[0005] This invention aims to overcome the shortcomings of existing technologies and provide a herbal ointment with significantly improved efficacy and low irritation, as well as its preparation method. The main technical solution of this invention is as described in the above claims. This invention extracts the effective components of Lithospermum erythrorhizon root using a cold extraction method, avoiding high-temperature destruction and maximizing the preservation of its active substances. After being compounded with a herbal ointment base, animal experiments and human trials have demonstrated that it reduces the time for the redness and itching caused by mosquito bites by approximately 50% compared to traditional products, and significantly reduces the allergy rate. Beneficial effects

[0006] The compound herbal ointment provided by this invention combines the dual effects of "anti-inflammatory and repairing" of purple gromwell root and "mosquito repellent and antipruritic" of mugwort leaf. The two are enhanced by cold extraction process, and compared with products with single extracts, its mosquito repellent effect is extended by 35%, and its antipruritic effect is more rapid. Experimental data

[0007] The herbal balm prepared in this embodiment was compared with a commercially available brand of traditional herbal balm (30 people in each group). The results showed that the average time for redness and swelling to subside after application of this product was (62±15) minutes, while that of the commercially available product was (125±28) minutes. No allergic reactions were observed with this product, while two cases of mild stinging sensation were observed with the commercially available product.

[0008] The above embodiments are merely preferred embodiments of the present invention and should not be construed as limiting the scope of protection of the present invention. Any non-substantial changes and substitutions made by those skilled in the art based on the present invention shall fall within the scope of protection claimed by the present invention.

Claims

1. A herbal paste containing a complex cold-extracted extract, characterized in that, It is made from raw materials comprising the following weight percentages: 90-98% herbal extract matrix and 2-10% compound cold extract; the compound cold extract is composed of cold extract of purple gromwell root and cold extract of mugwort.

2. The herbal paste as described in claim 1, characterized in that, In the compound cold extract, the mass ratio of Lithospermum root cold extract to Artemisia argyi cold extract is (1:0.5)-(1:2).

3. The herbal paste as described in claim 2, characterized in that, The cold-extracted extract of Lithospermum erythrorhizon root is prepared by the following method: after pulverizing dried Lithospermum erythrorhizon root, it is mixed with virgin coconut oil from Wenchang, Hainan at a mass-volume ratio of 1:8-1:12 (g / mL), soaked at 20-30℃ in the dark for 40-56 hours, then centrifuged and the supernatant is collected to obtain the extract.

4. The herbal paste as described in claim 3, characterized in that, The cold extract of Artemisia argyi was prepared by the following method: dried Artemisia argyi was pulverized and mixed with virgin coconut oil from Wenchang, Hainan, at a mass-volume ratio of 1:8-1:12 (g / mL). The mixture was soaked at 20-30℃ in the dark for 24-48 hours, then centrifuged and the supernatant was collected.

5. The herbal paste as described in claim 1, characterized in that, The amount of the compound cold extract added is 5%, wherein the mass ratio of the cold extract of Lithospermum erythrorhizon root to the cold extract of Artemisia argyi is 1:

1.

6. A method for preparing the herbal extract as described in any one of claims 1-5, characterized in that, The process includes the following steps: mixing the composite cold-extracted extract with the heated and melted herbal paste matrix under light-protected conditions, filling the container, and cooling it to form a solid shape.