Compound sterilization method of dragon's blood and compound capsule using sterilized dragon's blood

Abstract

The invention relates to the technical field of traditional Chinese medicine treatment, and aims to provide a compound sterilization method of dragon's blood and a compound capsule using sterilized dragon's blood. The method comprises the following steps: grinding dry dragon's blood into particles, and soaking the particles in an ethanol water solution to form a dragon's blood alcohol solution; transferring into a water bath to be volatilized until no alcohol smell exists, so as to obtain a dragon's blood extract, and performing sterilization treatment by microwave boiling; and cooling and drying under reduced pressure to obtain the sanguis draconis sterilized product. Compared with a high-pressure steam sterilization method and a single ethanol sterilization method in the traditional technology, the method disclosed by the invention has the advantages that the content of the active component dracorhodin perchlorate can be kept relatively stable while the microbial limit in the dragon's blood product meets the requirement. The method is simple and easy to operate, does not need to purchase novel instruments and equipment, is low in energy consumption, can greatly reduce the production cost, has wide market application value and space, and meets the requirements of industrial production.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine processing technology, and in particular to a compound sterilization treatment method for dragon's blood, as well as a traditional Chinese medicine compound preparation made using sterilized dragon's blood. Background Technology

[0002] Dragon's blood, also known as "Qilin Jie," is a traditional and precious Chinese medicine. The 2020 edition of the Chinese Pharmacopoeia records that it originates from the resin exuded from the fruit of the palm tree *Daemonorops draco* Bl., and is processed from this resin. Modern pharmacology has confirmed that it possesses various physiological activities, including antioxidant, blood-activating and hemostatic, lipid metabolism-improving, and microcirculation-improving effects. Currently, it is widely used clinically for trauma and gastrointestinal bleeding, with significant efficacy. However, due to its content of reducing sugars and resinous substances, it is susceptible to contamination by various microorganisms during production and storage. This results in high bacterial counts in Chinese medicine preparations using dragon's blood powder, with significant batch-to-batch variations, directly impacting the quality and safety of drugs containing dragon's blood. Therefore, dragon's blood generally requires sterilization to ensure the microbiological compliance of the medicine.

[0003] In traditional Chinese medicine preparations (such as capsules and granules) that use non-sterile raw medicinal materials as ingredients, microbial limits are typically controlled through methods such as heating during preparation. Because the main active ingredient in dragon's blood, daphne perchlorate, is thermally unstable, prolonged exposure to high temperatures (humid or dry heat) or heating conditions will cause it to decompose, leading to a significant decrease in the content of the active ingredient. Furthermore, as a resinous medicinal material, dragon's blood is easily encapsulated by bacteria, resulting in variations in bacterial load between batches. Even after pulverizing and sterilizing with ethanol alone, inconsistent treatment standards can lead to some batches failing microbial limit tests, and molds are not easily killed under ethanol conditions. In addition, instantaneous high-temperature sterilization of dragon's blood powder can cause clumping and adhesion to the container walls due to the melting of the powder at high temperatures, affecting the instantaneous high-temperature sterilization process. The melting of dragon's blood at high temperatures also affects subsequent formulation processes, preventing the use of high-temperature granulation methods such as spray drying. In existing published literature and patent texts, the currently applicable method may be to use cobalt-60 irradiation to sterilize drugs containing dragon's blood. However, this treatment method will cause changes in the efficacy of the drug, reduce the content of active ingredients, and affect the appearance and packaging. Moreover, it has problems such as radioactive residues, harsh sterilization conditions, and poor sterilization effect.

[0004] Given that many existing processing methods are insufficient to achieve the goal of sterilization while ensuring a relatively stable perchlorate content in dragon's blood, it is necessary to research and improve the sterilization methods for dragon's blood. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to overcome the shortcomings of the prior art and provide a compound sterilization method for dragon's blood and a compound capsule preparation using sterilized dragon's blood.

[0006] To solve the technical problem, the solution of the present invention is:

[0007] A method for sterilizing dragon's blood is provided, comprising: grinding dried dragon's blood into granules, soaking it in an aqueous ethanol solution to form a dragon's blood alcohol solution; evaporating it in a water bath until no alcohol odor is detected to obtain dragon's blood extract, sterilizing it by microwaving; and drying it under reduced pressure after cooling to obtain sterilized dragon's blood product.

[0008] As a preferred embodiment of the present invention, the blood dragon is ground into powder and then passed through a 100-mesh sieve.

[0009] As a preferred embodiment of the present invention, the volume percentage concentration of the ethanol aqueous solution is 80%, and the mass ratio of bloodwort granules to ethanol aqueous solution is 1:5 to 1:10.

[0010] As a preferred embodiment of the present invention, the soaking time of the blood dragon granules in the ethanol aqueous solution is 12 to 16 hours.

[0011] As a preferred embodiment of the present invention, the water bath temperature is 50-60°C.

[0012] As a preferred embodiment of the present invention, the temperature of the blood ointment is maintained at 100-105°C during the boiling sterilization process by controlling the microwave power.

[0013] As a preferred embodiment of the present invention, the microwave boiling sterilization time is controlled to be 8 to 13 minutes.

[0014] As a preferred embodiment of the present invention, the pressure during vacuum drying is controlled at 40-60 kPa and the temperature at 50-60°C.

[0015] The present invention further provides a compound capsule for blood-sucking herbs, comprising a capsule shell and a mixture of drug powder contained therein; the specific proportions of the raw materials in the drug powder mixture are as follows:

[0016] Panax notoginseng 8 parts, Asarum 1 part, Dragon's blood 2 parts, vinegar-processed Cyperus rotundus 10 parts, vinegar-processed Corydalis yanhusuo 13 parts, Poria cocos 10 parts, Salvia miltiorrhiza 10 parts, Citrus reticulata 10 parts, Angelica dahurica 6 parts;

[0017] All components are listed in parts by weight.

[0018] The blood dragon is the sterilized blood dragon prepared by the aforementioned method.

[0019] This invention further provides a method for preparing the aforementioned blood-spinning compound capsules, comprising:

[0020] (1) Take Panax notoginseng and Asarum, sterilize them at 105℃ for 15 minutes, dry them at below 60℃, and then grind them into fine powder for later use; take the sterilized blood dragon product and grind it into fine powder for later use.

[0021] (2) Take vinegar-processed Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Poria cocos, Salvia miltiorrhiza, Citrus reticulata peel, and Angelica dahurica and place them in an extraction pot. Add water and decoct twice. For the first decoction, add 8 times the amount of water and soak for 30 minutes. Heat to boiling and decoct for 2 hours. For the second decoction, add 6 times the amount of water and boil for 1.5 hours. Combine the decoctions and filter. Concentrate the filtrate to a relative density of 1.30 to 1.40 at 50 to 55°C to obtain a clear extract for later use.

[0022] (3) Take the three fine powders and an appropriate amount of starch from step (1) and add them to the clear paste prepared in step (2); mix well and granulate, dry initially and then granulate, and further dry at a temperature not exceeding 60°C; add an appropriate amount of magnesium stearate and then fill into capsules to obtain the blood dragon compound capsules.

[0023] Description of the invention principle:

[0024] This invention has two technical objectives: first, to kill aerobic bacteria, molds, and yeasts in dragon's blood; and second, to ensure that the content of the active ingredient, dragon's blood perchlorate, is not reduced due to the sterilization treatment. To those skilled in the art, these are two opposing and mutually exclusive technical objectives.

[0025] After long-term in-depth research and repeated experiments, the applicant's research team proposed a combined sterilization method for blood dragon's blood, which involves overnight ethanol soaking combined with microwave boiling. This technology has significant innovations, as detailed below:

[0026] First, the dragon's blood granules are dissolved in ethanol. Ethanol can penetrate the interior of the dragon's blood, killing most aerobic bacteria by denaturing microbial proteins. Then, it is treated in a water bath until no alcohol odor remains, allowing most of the ethanol in the dragon's blood alcohol solution to evaporate safely and gently, while avoiding the destruction of dragon's blood perchlorate. Further boiling of the dragon's blood extract is then performed to generate steam from the remaining water and a small amount of ethanol. The stronger penetrating power of the alcohol-containing steam kills residual microorganisms; high-temperature steam is particularly effective against molds that are difficult to kill in this product. Microwave boiling allows the internal water of the dragon's blood to penetrate from the inside out, rapidly killing microorganisms. Compared to traditional high-pressure steam sterilization, although both use steam, microwave sterilization is faster and reduces the degradation of dragon's blood perchlorate. During boiling, microwave power and processing time must be controlled. Excessive microwave power will cause localized overheating and damage to the dragon's blood components; insufficient power will not reach the required temperature threshold; excessive processing time will reduce the dragon's blood perchlorate content; and insufficient time will result in poor sterilization. Drying under reduced pressure is chosen to lower the boiling point, prevent the destruction of the perchlorate component of bloodwort, and accelerate the drying process, thereby improving efficiency.

[0027] Compared with the prior art, the technical advantages of the present invention are:

[0028] 1. Compared with traditional high-pressure steam sterilization and ethanol sterilization alone, the present invention can maintain the content of the active ingredient, bloodwort extract perchlorate, relatively stable while ensuring that the microbial limit in the bloodwort product meets the requirements.

[0029] 2. The blood-skin sterilization method of the present invention is simple and easy to operate, does not require the purchase of new instruments and equipment, has low energy consumption, can significantly reduce production costs, has broad market application value and space, and meets the needs of industrial production.

[0030] 3. This invention innovatively uses a composite sterilization method to screen the optimal sterilization scheme for dragon's blood powder. A practical application example is provided using the Shangtong Capsule as an example, offering a reference for other traditional Chinese medicine preparations that use dragon's blood powder as an ingredient. Detailed Implementation

[0031] The specific embodiments of the present invention will be described in detail below.

[0032] 1. Overview of the implementation scheme of the present invention

[0033] (1) The compound sterilization method for blood dragon provided by the present invention includes:

[0034] The dried dragon's blood is ground into granules and passed through a 100-mesh sieve. The granules are added to an 80% (v / v) ethanol-water solution at a mass ratio of 1:5 to 1:10. After soaking for 12–16 hours, a dragon's blood alcohol solution is formed. The alcohol solution is then evaporated in a water bath at 50–60°C until no alcohol odor remains, yielding a dragon's blood extract. This extract is then sterilized by microwave boiling, maintaining the temperature at 100–105°C (using an infrared temperature sensor for real-time monitoring) for 8–13 minutes by controlling the microwave power. After cooling, the extract is dried under reduced pressure at 40–60 kPa and 50–60°C to obtain the sterilized dragon's blood product.

[0035] (2) As an application example, the blood-skin sterilization of the present invention can be used to prepare blood-skin compound capsules. The compound capsules include a capsule shell and a mixture of drug powder contained therein; the specific proportions of the raw materials in the drug powder mixture are as follows: 8 parts of Panax notoginseng, 1 part of Asarum heterotropoides, 2 parts of blood-skin, 10 parts of vinegar-processed Cyperus rotundus, 13 parts of vinegar-processed Corydalis yanhusuo, 10 parts of Poria cocos, 10 parts of Salvia miltiorrhiza, 10 parts of Citrus reticulata peel, and 6 parts of Angelica dahurica; all the above components are in parts by weight.

[0036] The compound capsules can be prepared according to the process shown in Example 4, or by referring to the process described in other published literature.

[0037] 2. Examples and Comparative Examples

[0038] Example 1

[0039] Weigh an appropriate amount of dragon's blood, grind it and pass it through a 100-mesh sieve. Dissolve it in 80% (V / V) ethanol aqueous solution at a mass ratio of 5 and soak it overnight (16 hours). Dry it in a 55°C water bath until there is no alcohol smell. Microwave sterilize the dragon's blood extract at 105°C for 10 minutes by controlling the microwave power. Then dry it under reduced pressure at 50°C and 50 kPa to obtain the sterilized dragon's blood product.

[0040] Example 2

[0041] Weigh an appropriate amount of dragon's blood, grind it and pass it through a 100-mesh sieve. Dissolve it in an 80% (v / v) ethanol aqueous solution with a mass ratio of 8 and soak it overnight (14 hours). Dry it in a 50°C water bath until there is no alcohol smell. Microwave sterilize the dragon's blood extract at 100°C for 8 minutes by controlling the microwave power. Then dry it under reduced pressure at 60°C and 40 kPa to obtain the sterilized dragon's blood product.

[0042] Example 3

[0043] Weigh an appropriate amount of dragon's blood, grind it and pass it through a 100-mesh sieve. Dissolve it in 10 times its mass ratio of 80% (V / V) ethanol aqueous solution, soak it overnight (12 hours), and evaporate it in a 60°C water bath until there is no alcohol smell. Sterilize the dragon's blood extract by microwave at 103°C for 13 minutes by controlling the microwave power. Then dry it under reduced pressure at 55°C and 60 kPa to obtain the sterilized dragon's blood product.

[0044] Example 4: Preparation of Compound Capsules

[0045] The formulation of the compound capsule of the present invention is as follows: by weight

[0046] 8 parts Panax notoginseng, 2 parts Dragon's Blood, 1 part Asarum, 10 parts Vinegar-processed Cyperus rotundus, 13 parts Vinegar-processed Corydalis yanhusuo, 10 parts Poria cocos, 10 parts Salvia miltiorrhiza, 10 parts Citrus reticulata peel, and 6 parts Angelica dahurica.

[0047] The preparation process of the blood-spinning compound capsules of the present invention is as follows:

[0048] (1) Sterilize Panax notoginseng and Asarum at 105℃ for 15 minutes, dry (≤60℃), and then grind into fine powder for later use; take sterilized blood dung and grind into fine powder for later use.

[0049] (2) Place the vinegar-processed Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Poria cocos, Salvia miltiorrhiza, Citrus reticulata peel, and Angelica dahurica in an extraction pot, add water and decoct twice. For the first decoction, add 8 times the amount of water and soak for 30 minutes, heat to boiling and decoct for 2 hours. For the second decoction, add 6 times the amount of water and boil for 1.5 hours. Combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.30-1.40 (50-55℃) for later use.

[0050] (3) Add the fine powder from step (1) and an appropriate amount of starch to the clear paste from step (2), mix well, granulate, pre-dry, granulate, dry (≤60℃), add an appropriate amount of magnesium stearate, and fill into capsules to obtain the blood dragon compound capsules.

[0051] Dosage and administration: Take 6 capsules orally, 3 times a day.

[0052] The blood-skin compound capsules obtained by the compound sterilization method of this invention meet the requirements for large-scale production.

[0053] Comparative Example 1

[0054] Weigh out an appropriate amount of blocky dragon's blood and sterilize it by water bath at 60℃ for 12 hours and water bath at 80℃ for 6 hours respectively to obtain sterilized dragon's blood products.

[0055] Comparative Example 2

[0056] Weigh out appropriate amounts of blocky dragon's blood and coarse powder of dragon's blood that has passed through a 24-mesh sieve, and sterilize them in a water bath at 80°C for 6 hours to obtain sterilized dragon's blood.

[0057] Comparative Example 3

[0058] Weigh out an appropriate amount of dragon's blood, grind it into powder, pass it through a 24-mesh sieve, and sterilize it in a water bath at 90℃ for 6 hours to obtain sterilized dragon's blood.

[0059] Comparative Example 4

[0060] Weigh out an appropriate amount of dragon's blood, grind it into powder, pass it through a 24-mesh sieve, and sterilize it with high-pressure steam at 105℃ for 15 minutes to obtain sterilized dragon's blood.

[0061] Comparative Example 5

[0062] Take 8 portions of coarse dragon's blood powder that have passed through a 24-mesh sieve, and sterilize them using microwave sterilization methods at different temperatures and times to obtain sterilized dragon's blood products.

[0063] Comparative Example 6

[0064] Weigh out an appropriate amount of dragon's blood, grind it into powder, and pass it through a 24-mesh sieve. Dissolve it in 5, 10, and 15 times the amount of 80% ethanol, respectively, soak it for 12 hours, and dry it in a 50°C water bath until there is no alcohol smell. Then sterilize it in a microwave at 50°C for 30 minutes to obtain sterilized dragon's blood.

[0065] In the above comparative examples, "lumpy dragon's blood" refers to lumpy raw materials obtained from the market, which have not undergone drying and grinding. "Dragon's blood" refers to raw materials that have been dried but not ground, the same as the raw materials used in Examples 1-3 of this invention. "Coarse dragon's blood powder" refers to raw materials that have been dried and ground through a 24-mesh sieve, and whose particle size is larger than that of the particles in Examples 1-3 of this invention.

[0066] 3. Product Test Results and Analysis

[0067] (1) The product testing content for each embodiment and comparative example includes the perchlorate content of bloodwort and the detection of microorganisms. The specific testing methods are as follows.

[0068] Determination of dracosanol perchlorate: Refer to the high-performance liquid chromatography method (Chinese Pharmacopoeia 2020 Edition, Part IV, General Chapter 0512). Chromatographic conditions and system suitability test: Octadecylsilane-bonded silica gel was used as the stationary phase; acetonitrile-0.05 mol / L sodium dihydrogen phosphate solution (50:50) was used as the mobile phase; the detection wavelength was 272 nm. The theoretical plate number calculated based on dracosanol perchlorate should not be less than 4000. Preparation of reference solution: Accurately weigh 9 mg of dracosanol perchlorate reference standard, place it in a 50 ml brown volumetric flask, add 3% phosphate methanol solution to dissolve it, and dilute to the mark. Shake well. Accurately measure 1 ml of the solution, place it in a 5 ml volumetric flask, add methanol to the mark, and shake well. Preparation of the test solution: Take an appropriate amount of this product, grind it finely, accurately weigh 0.05-0.15 g, place it in a stoppered test tube, accurately add 10 ml of 3% phosphate methanol, stopper tightly, shake for 3 minutes, filter, accurately measure 1 ml of the filtrate, place it in a 5 ml volumetric flask, add methanol to the mark, shake well, and the solution is ready. Accurately pipette 10 μl each of the reference solution and the test solution, inject them into the liquid chromatograph, and determine the results.

[0069] Microbial Detection Method: Accurately weigh 10g each of unsterilized dragon's blood samples and samples treated according to various examples or comparative proportions. Add 100mL of sterile sodium chloride-peptone buffer (pH 7.0) to make a 1:10 test solution. Shake thoroughly (for at least 15 minutes). Use the liquid as the test solution and further dilute it 10-fold with the above buffer. Aerobic Bacterial Culture: Pour 1ml of the test solution into a Petri dish, add 15-20ml of tryptic soy agar medium, mix well, allow to solidify, and incubate upside down at 30-35℃ for 3-5 days. Mold and Yeast Culture: Replace the medium with Sabouraud dextrose agar medium and incubate upside down at 20-25℃ for 5-7 days. Prepare two Petri dishes for each of the above experiments. The results are interpreted according to the 2020 edition of the Chinese Pharmacopoeia, Part IV, General Chapter 1107, Microbial Limit Standard Test Method for Non-sterile Drugs. Total Aerobic Bacterial Count Test: Not exceeding 10 4 (cfu / g); Total mold and yeast count: not exceeding 10 2 (cfu / g).

[0070] (2) The blood-blood sterilized samples obtained in Examples 1-3 and the blood-blood samples before sterilization were subjected to blood-blood perchlorate content determination and / or microbial detection, and the results are shown in Table 1.

[0071] Table 1. Sterilization effect and perchlorate content of each embodiment.

[0072]

[0073]

[0074] Using the blood-skin sterilized sample from Example 1, three batches of compound capsule samples were prepared according to the method of Example 4. The microbiological test results of these three batches of samples are shown in Table 2.

[0075] Table 2. Microbiological test results of three batches of compound capsule samples

[0076]

[0077] The samples obtained from Comparative Examples 1-6 and the unsterilized dragon's blood were subjected to determination of the perchlorate content of dragon's blood extract and / or microbial detection. The experimental results are shown in Tables 3-8.

[0078] Table 3. Results of the effect of water bath sterilization temperature and time on microorganisms on the surface of blood dung blocks (Comparative Example 1)

[0079]

[0080] Table 4. Results of the study on the effect of pulverization on the sterilization effect of blood stasis (Comparative Example 2)

[0081]

[0082] Table 5. Changes in the content of active ingredients before and after sterilization at 90℃ for 6 hours (Comparative Example 3)

[0083]

[0084] Table 6. Changes in the content of active ingredients before and after autoclaving at 105℃ for 15 minutes (Comparative Example 4)

[0085]

[0086]

[0087] Table 7 Results of the study on the effect of microwave sterilization time and temperature on the sterilization effect of bloodwort (Comparative Example 5)

[0088]

[0089] Table 8. Results of the sterilization effect of 80% ethanol combined with microwave sterilization on bloodwort (Comparative Example 6)

[0090]

[0091] The results in Table 3-8 show that Comparative Examples 1-3 changed the water bath temperature and time, but the sterilization effect remained poor; moreover, the perchlorate content of dragon's blood decreased with the increase of water bath temperature and time. This proves that the water bath low-temperature long-term sterilization method for dragon's blood is not feasible; it also proves that there are a large number of microorganisms inside the dragon's blood block, so it should be crushed before sterilization. Comparative Example 4 used high-pressure steam sterilization at 105℃ for 15 minutes, and the perchlorate content of dragon's blood decreased significantly, proving that the moist heat high-temperature high-pressure sterilization method for dragon's blood is also not feasible. Comparative Example 5 changed the time and temperature of microwave sterilization of dragon's blood solution, and the sterilization effect was poor; moreover, increasing the microwave temperature and extending the time both reduced the perchlorate content of dragon's blood, so the simple microwave dry heat sterilization condition is also not feasible. Comparative Example 6 used simple 80% ethanol sterilization plus microwave low-temperature drying, and the sterilization effect was also unsatisfactory.

[0092] The data from the above embodiments and comparative examples are sufficient to prove that the composite sterilization method described in this invention is the optimal sterilization scheme for blood dragon; while ensuring that the microbial limit in blood dragon medicine meets the requirements, it can maintain the relatively stable content of the active ingredient blood dragon perchlorate.

[0093] The specific embodiments of the present invention have been described above. It should be understood that the present invention is not limited to the specific embodiments described above, and those skilled in the art can make various modifications or variations within the scope of the claims, which do not affect the essence of the present invention.

Claims

1. A compound sterilization method for dragon's blood, characterized in that, include: The dried dragon's blood is ground into granules and soaked in an ethanol-water solution to form a dragon's blood alcohol solution. It is then transferred to a water bath and evaporated until there is no alcohol odor to obtain dragon's blood extract. It is then sterilized by microwaving and boiling. After cooling, it is dried under reduced pressure to obtain sterilized dragon's blood product.

2. The method according to claim 1, characterized in that, After grinding the blood dragon into powder, pass it through a 100-mesh sieve.

3. The method according to claim 1, characterized in that, The volume percentage concentration of the ethanol-water solution is 80%, and the mass ratio of blood dragon granules to the ethanol-water solution is 1:5 to 1:

10.

4. The method according to claim 1, characterized in that, The soaking time for blood dragon granules in an ethanol aqueous solution is 12 to 16 hours.

5. The method according to claim 1, characterized in that, The water bath temperature is 50-60℃.

6. The method according to claim 1, characterized in that, By controlling the microwave power, the temperature of the bloodwort extract is maintained at 100-105℃ during the boiling sterilization process.

7. The method according to claim 1, characterized in that, The microwave boiling sterilization time should be controlled to be 8 to 13 minutes.

8. The method according to claim 1, characterized in that, The pressure during vacuum drying is controlled at 40–60 kPa and the temperature at 50–60 °C.

9. A compound capsule for treating dragon's blood, comprising a capsule shell and a mixture of drug powder contained therein; characterized in that, The specific proportions of the raw materials in the drug powder mixture are as follows: Panax notoginseng 8 parts, Asarum 1 part, Dragon's blood 2 parts, vinegar-processed Cyperus rotundus 10 parts, vinegar-processed Corydalis yanhusuo 13 parts, Poria cocos 10 parts, Salvia miltiorrhiza 10 parts, Citrus reticulata 10 parts, Angelica dahurica 6 parts; All components are listed in parts by weight. The blood dragon is a sterilized blood dragon product prepared by the method described in any one of claims 1 to 8.

10. The method for preparing the blood-spinning compound capsules according to claim 9, characterized in that, include: (1) Take Panax notoginseng and Asarum, sterilize them at 105℃ for 15 minutes, dry them at below 60℃, and then grind them into fine powder for later use; take the sterilized blood dragon product and grind it into fine powder for later use. (2) Take vinegar-processed Cyperus rotundus, vinegar-processed Corydalis yanhusuo, Poria cocos, Salvia miltiorrhiza, Citrus reticulata peel, and Angelica dahurica and place them in an extraction pot. Add water and decoct twice. For the first decoction, add 8 times the amount of water and soak for 30 minutes. Heat to boiling and decoct for 2 hours. For the second decoction, add 6 times the amount of water and boil for 1.5 hours. Combine the decoctions and filter. Concentrate the filtrate to a relative density of 1.30 to 1.40 at 50 to 55°C to obtain a clear extract for later use. (3) Take the three fine powders and an appropriate amount of starch from step (1) and add them to the clear paste prepared in step (2); mix well and granulate, dry initially and then granulate, and further dry at a temperature not exceeding 60°C; add an appropriate amount of magnesium stearate and then fill into capsules to obtain the blood dragon compound capsules.

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