Hair preparation for killing mites and relieving scalp inflammation and preparation process

Abstract

The invention relates to the field of cosmetics, in particular to a hair preparation for killing mites and relieving scalp inflammation and a preparation process. The composition for killing mites and relieving scalp inflammation is prepared from salicylic acid, azelaic acid, a citronella extract, a herba violae extract, a herba houttuyniae / radix scutellariae extract, a solvent, a solubilizer and water, and then the composition is applied to a hair preparation. The composition has excellent acarus killing and anti-inflammatory performance, and the hair composition is endowed with excellent performance.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to a hair preparation for killing mites and relieving inflammation of the scalp and a preparation process thereof. BACKGROUND

[0002] In the field of personal care, scalp health is increasingly valued. As a special part of human skin, the scalp is long exposed to the outside world and is easily affected by various factors. Among them, mite breeding and scalp inflammation are common problems that seriously affect people's quality of life and image.

[0003] Mites, especially Demodex folliculorum, breed in large numbers in the scalp environment. Mites feed on the sebum secreted by the scalp, and their metabolic products and carcasses easily block the hair follicles, hindering the normal nutrient supply and excretion of the hair follicles, and thus triggering a series of scalp problems. Hair follicle blockage can cause imbalance in the secretion of scalp sebum, making the hair greasy and unmanageable, affecting the freshness and styling of the hair; more seriously, mites stimulate the immune system of the scalp, triggering an inflammatory response, resulting in symptoms such as scalp itching, redness, and scaling. Long-term inflammation can also affect the health of the hair follicles, leading to hair thinning and shedding.

[0004] Scalp inflammation is also a problem that plagues many consumers. In addition to being induced by mites, the causes of scalp inflammation are complex and varied. Modern people have a fast-paced life and high stress, which can easily cause endocrine disorders, affect the secretion of scalp sebum, disrupt the balance of the scalp micro-ecosystem, create conditions for the breeding of harmful microorganisms, and thus trigger inflammation. Frequent hair perming and dyeing, the use of inferior hair care products, and environmental pollution can also directly stimulate and damage the scalp, weaken the scalp barrier function, and make the scalp more vulnerable to inflammatory attacks. Common scalp inflammation includes seborrheic dermatitis and contact dermatitis, which not only cause physical discomfort such as unbearable itching and pain, but also can cause psychological burden to patients due to appearance problems.

[0005] Currently, there are many hair preparations on the market to address the problems of scalp mites and inflammation, but most of them have limitations. Traditional mite-killing hair preparations mostly use chemical synthetic mite-killing agents such as benzyl benzoate and dicloran. Although these ingredients can kill mites to some extent, they are highly irritating and can easily disrupt the normal secretion of sebum and the micro-ecological environment of the scalp when used for a long time, leading to dry scalp, allergies, and even exacerbation of inflammatory reactions. Moreover, with the increasing resistance of mites, the effectiveness of chemical mite-killing agents gradually decreases.

[0006] For hair preparations targeting scalp inflammation, some add glucocorticoids or antibiotics, which can quickly relieve inflammatory symptoms, but long-term use can have many side effects, such as hormone-dependent dermatitis and dysbiosis. In addition, some products that claim to have the effect of soothing scalp inflammation have unclear mechanisms of action and can only provide temporary relief, failing to address the root cause of inflammation.

[0007] Therefore, it is necessary to develop a hair preparation which can effectively remove mites, safely and effectively relieve scalp inflammation, and is friendly to the scalp microecological environment, and a preparation process thereof. SUMMARY

[0008] The present application aims at the above technical problems, and provides a hair preparation for removing mites and relieving scalp inflammation and a preparation process thereof.

[0009] The present application provides a composition for removing mites and relieving scalp inflammation, raw materials of which include salicylic acid, azelaic acid, citronella extract, viola philippica extract, houttuynia cordata / scutellaria baicalensis extract, solvent, solubilizer and water.

[0010] In one specific embodiment, the solvent in the composition includes at least one of ethylene glycol, propylene glycol, butylene glycol and glycerol.

[0011] In one specific embodiment, the solubilizer in the composition includes at least one of tween-20, tween-40 and polyglyceryl-10 laurate.

[0012] In one specific embodiment, the composition includes salicylic acid 0.05-0.3%, azelaic acid 0.05-0.3%, citronella extract 0.5-2.5%, viola philippica extract 0.5-2.5%, houttuynia cordata / scutellaria baicalensis extract 0.7-4.5%, solvent 15-30%, solubilizer 5-10% and the rest water, according to the weight percentage.

[0013] In one specific embodiment, the weight ratio of citronella extract and viola philippica extract in the composition is 1:0.5-1.5.

[0014] In one specific embodiment, the preparation method of citronella extract in the composition includes selecting 80-95wt% ethanol solution for extraction.

[0015] In one specific embodiment, the preparation method of citronella extract in the composition includes: drying and crushing the whole plant of citronella, then adding 80-95wt% ethanol solution according to the ratio of 1:5-30g / mL, stirring and extracting at the temperature of 40-65℃ for 3-8 hours, filtering and concentrating to obtain.

[0016] In one specific embodiment, the preparation method of viola philippica extract in the composition includes selecting 70-85wt% ethanol solution for extraction.

[0017] In one embodiment, the preparation method of the extract of Hedy siffalcatra in the composition comprises: drying the whole plant of Hedy siffalcatra, crushing, then adding 70-85 wt% ethanol solution according to the ratio of 1:5-30 g / mL, stirring and extracting at 45-65℃ for 3-8 hours, filtering, and concentrating to obtain.

[0018] In one embodiment, the preparation method of the extract of Hedy siffalcatra in the composition comprises: drying the whole plant of Hedy siffalcatra, crushing, then adding 70-85 wt% ethanol solution according to the ratio of 1:5-30 g / mL, stirring and extracting at 45-65℃ for 3-8 hours, filtering, and concentrating to obtain.

[0019] In one embodiment, the preparation method of the extract of Hedy siffalcatra in the composition comprises: drying the whole plant of Hedy siffalcatra, crushing, then adding 70-85 wt% ethanol solution according to the ratio of 1:5-30 g / mL, stirring and extracting at 45-65℃ for 3-8 hours, filtering, and concentrating to obtain.

[0020] The present application also provides a preparation method of the composition, comprising heating water, adding a solubilizing agent and stirring to obtain mixture one; heating a solvent, adding salicylic acid, azelaic acid, citronella extract, Hedy siffalcatra extract and Houttuynia cordata / Scutellaria baicalensis extract, and stirring to obtain mixture two; adding mixture two to mixture one, continuing to stir, sterilizing, and obtaining the composition.

[0021] In one embodiment, the water is heated to 50-70℃.

[0022] In one embodiment, the water is heated to 50-70℃.

[0023] The application also provides a hair preparation for killing mites and relieving inflammation of the scalp, which comprises, by weight percentage, 1-15% of the composition according to any one of claims 1-7, 2-4% of glycerol, 4-8% of alkyl glucoside, 3-6% of cocamidopropyl betaine, 2-4.5% of sodium lauroyl glutamate, 0.1-0.8% of rosemary extract, 0.5-2% of avocado oil, 0.5-1.5% of camellia seed oil, 0.1-1% of ginseng extract, 0.01-0.2% of polyquaternium-10, 0.5-2% of carbomer-941, 0.1-0.4% of a pH regulator, 0.1-0.3% of a preservative, and the balance of water.

[0024] The application also provides a preparation method of the hair preparation, which comprises the steps of adding water into a container, heating, and adding and stirring the remaining raw materials.

[0025] The application has the following beneficial technical effects:

[0026] The application uses salicylic acid, azelaic acid, citronella extract, viola philippica extract, houttuynia cordata / scutellaria baicalensis extract, a solvent, a solubilizer, and water to prepare a composition for killing mites and relieving inflammation of the scalp, which is then applied to a hair preparation. The composition has excellent mite-killing and anti-inflammatory properties, and endows the hair preparation with excellent properties.

[0027] The citronella extract and the viola philippica extract prepared by the application can inhibit the expression of inflammatory factors TNF-α and IL-1β at low concentrations, both of which have anti-inflammatory effects, and the two have a certain synergistic effect on improving the anti-inflammatory effect. In particular, when the ratio of the two is in the range of 1:0.5-1.5, the synergistic effect is particularly obvious, and the anti-inflammatory performance is very good.

[0028] The houttuynia cordata / scutellaria baicalensis extract prepared by the application has a good killing effect on mites at low concentrations, and the killing rate reaches about 99.2%.

[0029] In the application, when houttuynia cordata and scutellaria baicalensis are extracted together, the extract obtained by using 50-75wt% ethanol for extraction has a better mite-killing effect. In addition, the application uses extraction to further improve the mite-killing effect, and chloroform and cyclohexane are used as the organic phase for extraction in the extraction stage, which can greatly improve the mite-killing effect of the extract compared with using one of them as the organic phase. The ratio of chloroform and cyclohexane is changed, and in particular when the ratio is 1:0.5-1.3, the mite-killing effect of the extract obtained is better.

[0030] The hair preparation prepared by using the composition has a good effect of relieving itching and improving oily hair. BRIEF DESCRIPTION OF DRAWINGS

[0031] Figure 1Inhibition effect of the extract group on TNF-α expression

[0032] Figure 2 Inhibition effect of the extract group on IL-1β expression

[0033] Figure 3 Test results of the mite removal rate of each group DETAILED DESCRIPTION

[0034] The technical solutions in the specific embodiments of the application will be described in detail below.

[0035] I. Preparation and testing of citronella extract and viola philippevillii extract

[0036] The citronella extract and the viola philippevillii extract were prepared, and the anti-inflammatory effects of different collocation groups were studied.

[0037] The citronella extract was prepared by drying the whole plant of citronella to a water content of 1.67 wt%, crushing it to less than 0.3 mm, then adding 85 wt% ethanol solution in a sealed container at a solid-liquid ratio of 1:15 g / mL, stirring at a speed of 100 rpm at a temperature of 52℃ for 5 hours, filtering through a 0.22 μm filter membrane, and concentrating the filtrate under reduced pressure at 60℃ and 0.008 Mpa to a water content of 1.78 wt% to obtain the citronella extract.

[0038] The viola philippevillii extract was prepared by drying the whole plant of viola philippevillii to a water content of 1.54 wt%, crushing it to less than 0.3 mm, then adding 80 wt% ethanol solution in a sealed container at a solid-liquid ratio of 1:17.5 g / mL, stirring at a speed of 100 rpm at a temperature of 50℃ for 4.5 hours, filtering through a 0.22 μm filter membrane, and concentrating the filtrate under reduced pressure at 60℃ and 0.008 Mpa to a water content of 1.59 wt% to obtain the viola philippevillii extract.

[0039] The anti-inflammatory effect of the test samples of the test groups prepared using the citronella extract and the viola philippevillii extract was tested. The sample collocations are shown in Table 1. In the test groups, A represents the weight ratio of the citronella extract to the viola philippevillii extract.

[0040] Table 1: Sample composition

[0041] Group Group 1 Group 2 Group 3 Group 4 Group 5 Group 6 Group 7 Group 8 Group 9 Group 10 A 1:0 1:0.1 1:0.3 1：0.5 1:1 1:1.2 1:1.5 1:2 1:5 0:1

[0042] The anti-inflammatory effect of the test samples of the test groups in Table 1 above was tested. The specific test process is as follows:

[0043] Reagents and equipment: HaCaT cells, LPS, samples, culture medium (DMEM culture medium), cell culture plates, and ELISA kit.

[0044] Experimental operation process: logarithmic growth period RAW264.7 cells and culture medium were added to a 24-well plate, 0.5 mL per well, and the cell density in each well was 1.20 x 10 5 Each group was given a drug culture: LPS was added to the model group well plate to 1 μg / mL for 24 hours, and the culture medium was replaced and continued to culture for 24 hours; LPS was added to the group 1-10 well plate to 1 μg / mL for 24 hours, and the culture medium was replaced and group 1-10 samples were added to a total concentration of 175 μg / mL for 24 hours; the blank group was not treated and continuously cultured for 48 hours; the culture conditions of each group were 37°C, 5% CO2 constant temperature culture. After the drug culture was completed, the supernatant in the well plate was taken, and the expression concentration of TNF-α and IL-1β was detected according to the method recorded in the instruction manual of the ELISA kit. The results are shown in Table 2 and the attached Figure 1-2 .

[0045] Table 2: TNF-α and IL-1β expression concentration

[0046] Serial number TNF-α / ng / L IL-1β / ng / L Blank group 465.74 48.93 Model group 718.38 102.65 Group 1 608.92 83.81 Group 2 589.14 78.92 Group 3 557.36 70.87 Group 4 537.28 65.76 Group 5 523.19 62.18 Group 6 530.73 64.11 Group 7 542.97 67.20 Group 8 560.85 71.79 Group 9 598.76 81.43 Group 10 615.31 85.64

[0047] According to Tables 1-2 and the attached Figure 1-2 content, the citronella extract and the purple hedyis extract can inhibit the expression of inflammatory factors TNF-α and IL-1β at low concentrations, both of which have anti-inflammatory effects. In groups 2-9, the ratio of the two is changed from 1:0.1 to 1:5, and the anti-inflammatory ability produced by the combination is weak, then it becomes weak again, the effect of the combination of the two in groups 2-9 (the total concentration of active ingredients is the same as that of groups 1 and 10) is better than that of groups 1 and 10 alone, and the effect of citronella extract and purple hedyis extract, indicating that the combination of the two has a certain synergistic effect in improving the anti-inflammatory effect. Especially when the ratio of the two is in the range of 1:0.5-1.5, the synergistic effect is particularly obvious, and it has very good anti-inflammatory performance.

[0048] II. Preparation and testing of Houttuynia cordata / Scutellaria baicalensis extract

[0049] Houttuynia cordata / Scutellaria baicalensis extract (hereinafter referred to as sample 1#-8#) was prepared, and the acaricidal effect of the extract obtained by different extraction processes was studied. Houttuynia cordata root and Scutellaria baicalensis root were dried to contain about 2.73wt% water, then crushed to below 0.3mm, and used.

[0050] 1#, the preparation of the extract is as follows:

[0051] The above-mentioned Houttuynia cordata Thunb. and Scutellaria baicalensis Georgi powder on standby were mixed according to the weight ratio of 1:2 to obtain a mixture, 60wt% ethanol solution was added according to the solid-liquid ratio of 1:15g / mL, and was placed in a sealed reaction container, and was extracted at 100rpm under stirring at 50°C for 4 hours, and then was filtered through a 0.22μm filter membrane, and the filtrate was concentrated at 55°C under reduced pressure to a filtrate weight of 12.5% to obtain a concentrate, and the concentrate was extracted at 40°C under stirring at 60rpm for 2 hours using an extractant (the extractant was composed of an organic solvent and water according to the volume ratio of 1:0.3, and the organic solvent was composed of chloroform and cyclohexane according to the volume ratio of 1:0.5) according to the mass ratio of 1:10, was left to stand at room temperature for 1 hour to be layered, and the organic solvent layer was taken, and then was concentrated at 50°C under reduced pressure until the chloroform and cyclohexane were removed to stop the concentration to obtain the extract.

[0052] 2#, the extract was prepared as follows:

[0053] The above-mentioned Houttuynia cordata Thunb. and Scutellaria baicalensis Georgi powder on standby were mixed according to the weight ratio of 1:3.5 to obtain a mixture, 75wt% ethanol solution was added according to the solid-liquid ratio of 1:18g / mL, and was placed in a sealed reaction container, and was extracted at 100rpm under stirring at 52°C for 4.5 hours, and then was filtered through a 0.22μm filter membrane, and the filtrate was concentrated at 55°C under reduced pressure to a filtrate weight of 12.1% to obtain a concentrate, and the concentrate was extracted at 40°C under stirring at 60rpm for 2.5 hours using an extractant (the extractant was composed of an organic solvent and water according to the volume ratio of 1:0.4, and the organic solvent was composed of chloroform and cyclohexane according to the volume ratio of 1:1.3) according to the mass ratio of 1:12, was left to stand at room temperature for 1 hour to be layered, and the organic solvent layer was taken, and then was concentrated at 50°C under reduced pressure until the chloroform and cyclohexane were removed to stop the concentration to obtain the extract.

[0054] 3#, the extract was prepared as follows:

[0055] The above-mentioned Houttuynia cordata Thunb. and Scutellaria baicalensis Georgi powder on standby were mixed according to the weight ratio of 1:2 to obtain a mixture, 25wt% ethanol solution was added according to the solid-liquid ratio of 1:15g / mL, and was placed in a sealed reaction container, and was extracted at 100rpm under stirring at 50°C for 4 hours, and then was filtered through a 0.22μm filter membrane, and the filtrate was concentrated at 55°C under reduced pressure to a filtrate weight of 12.5% to obtain a concentrate, and the concentrate was extracted at 40°C under stirring at 60rpm for 2 hours using an extractant (the extractant was composed of an organic solvent and water according to the volume ratio of 1:0.3, and the organic solvent was composed of chloroform and cyclohexane according to the volume ratio of 1:0.5) according to the mass ratio of 1:10, was left to stand at room temperature for 1 hour to be layered, and the organic solvent layer was taken, and then was concentrated at 50°C under reduced pressure until the chloroform and cyclohexane were removed to stop the concentration to obtain the extract.

[0056] 4#, the extract was prepared as follows:

[0057] The above-mentioned prepared Houttuynia cordata Thunb. and Scutellaria baicalensis Georgi powders were mixed according to a weight ratio of 1:2 to obtain a mixture, 60wt% ethanol solution was added to the mixture according to a solid-liquid ratio of 1:15g / mL, and the mixture was placed in a sealed reaction container and extracted at 50°C and 100rpm for 4 hours, followed by 0.22μm membrane filtration, 55°C reduced-pressure concentration of the filtrate to 12.5% of the weight of the filtrate to obtain a concentrate, and extraction of the concentrate according to a mass ratio of 1:10 using an extraction agent (the extraction agent was composed of an organic solvent and water according to a volume ratio of 1:0.3, and the organic solvent was chloroform) at 40°C and 60rpm for 2 hours, standing at room temperature for 1 hour for layer separation, and taking the organic solvent layer, followed by 50°C reduced-pressure concentration until the chloroform was removed to stop the concentration, to obtain the extract.

[0058] 5#, the extract was prepared as follows:

[0059] The above-mentioned prepared Houttuynia cordata Thunb. and Scutellaria baicalensis Georgi powders were mixed according to a weight ratio of 1:2 to obtain a mixture, 60wt% ethanol solution was added to the mixture according to a solid-liquid ratio of 1:15g / mL, and the mixture was placed in a sealed reaction container and extracted at 50°C and 100rpm for 4 hours, followed by 0.22μm membrane filtration, 55°C reduced-pressure concentration of the filtrate to 12.5% of the weight of the filtrate to obtain a concentrate, and extraction of the concentrate according to a mass ratio of 1:10 using an extraction agent (the extraction agent was composed of an organic solvent and water according to a volume ratio of 1:0.3, and the organic solvent was chloroform) at 40°C and 60rpm for 2 hours, standing at room temperature for 1 hour for layer separation, and taking the organic solvent layer, followed by 50°C reduced-pressure concentration until the chloroform was removed to stop the concentration, to obtain the extract.

[0060] 6#, the extract was prepared as follows:

[0061] The above-mentioned prepared Houttuynia cordata Thunb. and Scutellaria baicalensis Georgi powders were mixed according to a weight ratio of 1:2 to obtain a mixture, 60wt% ethanol solution was added to the mixture according to a solid-liquid ratio of 1:15g / mL, and the mixture was placed in a sealed reaction container and extracted at 50°C and 100rpm for 4 hours, followed by 0.22μm membrane filtration, 55°C reduced-pressure concentration of the filtrate to 12.5% of the weight of the filtrate to obtain a concentrate, and extraction of the concentrate according to a mass ratio of 1:10 using an extraction agent (the extraction agent was composed of an organic solvent and water according to a volume ratio of 1:0.3, and the organic solvent was chloroform) at 40°C and 60rpm for 2 hours, standing at room temperature for 1 hour for layer separation, and taking the organic solvent layer, followed by 50°C reduced-pressure concentration until the chloroform was removed to stop the concentration, to obtain the extract.

[0062] 7#, the extract was prepared as follows:

[0063] The above-mentioned Houttuynia cordata Thunb. and Scutellaria baicalensis Georgi powder is mixed according to a weight ratio of 1:2 to obtain a mixture, 60wt% ethanol solution is added according to a solid-liquid ratio of 1:15g / mL, and then the mixture is placed in a sealed reaction container, stirred at 100rpm at 50°C for 4 hours, filtered through a 0.22μm filter membrane, and then the filtrate is concentrated at 55°C under reduced pressure to a filtrate weight of 12.5% to obtain a concentrate. The concentrate is extracted at 40°C for 2 hours at 60rpm using an extractant (the extractant is composed of an organic solvent and water according to a volume ratio of 1:0.3, and the organic solvent is composed of chloroform and cyclohexane according to a volume ratio of 1:0.1) according to a mass ratio of 1:10, and then the mixture is left to stand at room temperature for 1 hour to separate the layers, the organic solvent layer is taken, and then the mixture is concentrated at 50°C under reduced pressure until the chloroform and cyclohexane are removed to stop the concentration to obtain the extract.

[0064] 8#, the extract is prepared as follows:

[0065] The above-mentioned Houttuynia cordata Thunb. and Scutellaria baicalensis Georgi powder is mixed according to a weight ratio of 1:2 to obtain a mixture, 60wt% ethanol solution is added according to a solid-liquid ratio of 1:15g / mL, and then the mixture is placed in a sealed reaction container, stirred at 100rpm at 50°C for 4 hours, filtered through a 0.22μm filter membrane, and then the filtrate is concentrated at 55°C under reduced pressure to a filtrate weight of 12.5% to obtain a concentrate. The concentrate is extracted at 40°C for 2 hours at 60rpm using an extractant (the extractant is composed of an organic solvent and water according to a volume ratio of 1:0.3, and the organic solvent is composed of chloroform and cyclohexane according to a volume ratio of 1:3.5) according to a mass ratio of 1:10, and then the mixture is left to stand at room temperature for 1 hour to separate the layers, the organic solvent layer is taken, and then the mixture is concentrated at 50°C under reduced pressure until the chloroform and cyclohexane are removed to stop the concentration to obtain the extract.

[0066] The above-mentioned extract samples 1#-8# are tested for the effect of mite removal by the following method.

[0067] The efficiency η value of the drug for killing dust mites in 24 hours is tested according to the method described in NY / T1151.2-2006, each group is tested in triplicate, 1000 mites are used for each test, the drug is the above-mentioned extract samples 1#-8# which are diluted to 0.5wt‰ using a solvent, and the solvent is composed of ethylene glycol and water according to a weight ratio of 1:3. The specific test results are shown in Table 3 and Figure 3 wherein, Δη is the η difference value of sample 1# and other samples.

[0068] Table 3: Mite removal effect Serial number η Δη 1# 99.2% / 2# 98.7% 0.5% 3# 81.3% 17.9% 4# 88.6% 10.6% 5# 92.5% 6.7% 6# 91.1% 8.1% 7# 94.6% 4.6% 8# 95.8% 3.4%

[0069] Combined with Table 3 and Figure 3 The test results show that the above-mentioned extract has a good killing effect on mites at a low concentration, and the killing rate is about 99.2%.

[0070] According to the comparison of samples 1#-8#, it can be seen that the adjustment of the extraction process significantly affects the acaricidal performance of the Houttuynia cordata / Scutellaria baicalensis extract. When co-extracting Houttuynia cordata and Scutellaria baicalensis, the extract obtained by extraction with 50-75 wt% ethanol has better acaricidal effect, which can be obtained by comparing 1# with 3#, 4#. Further, the present application uses extraction to improve the acaricidal effect. In the extraction stage, chloroform and cyclohexane are used as the organic phase, which can greatly improve the acaricidal effect of the extract compared with using one of them as the organic phase. This can be obtained by comparing the comparison results of 1#, 2#, 5# and 6#. According to the comparison of 1#, 2#, 7# and 8#, it can be seen that changing the ratio of chloroform and cyclohexane, especially when the ratio is 1:0.5-1.3, the extract obtained has better acaricidal effect.

[0071] III. Application and Test

[0072] 1. Preparation of the composition

[0073] Composition 1: ingredients by weight percentage: salicylic acid 0.1%, azelaic acid 0.15%, citronella extract 2%, viola yedoensis extract 2%, Houttuynia cordata / Scutellaria baicalensis extract 3.5%, solvent 25%, solubilizer 8%, and the balance water; the solvent is composed of ethylene glycol and 1,3-butanediol in a mass ratio of 1:2; the solubilizer is composed of Tween-20 and polyglyceryl-10 laurate in a mass ratio of 1:1.5; the citronella extract and the viola yedoensis extract are prepared according to the method in section I above; the Houttuynia cordata / Scutellaria baicalensis extract is extract 1#.

[0074] Specific preparation method: heat water to 65°C, add solubilizer and stir at 100 rpm for 5 minutes to obtain mixture one; heat the solvent to 45°C, add salicylic acid, azelaic acid, citronella extract, viola yedoensis extract and Houttuynia cordata / Scutellaria baicalensis extract, and stir at 100 rpm for 15 minutes to obtain mixture two; add mixture two to mixture one, continue to stir at 200 rpm for 30 minutes, sterilize to obtain the composition.

[0075] Composition 2: Composition 1: ingredients by weight percentage: salicylic acid 0.11%, azelaic acid 0.2%, citronella extract 2.5%, viola yedoensis extract 1.5%, Houttuynia cordata / Scutellaria baicalensis extract 3.6%, solvent 23%, solubilizer 8.2%, and the balance water; the solvent is composed of ethylene glycol and glycerol in a mass ratio of 1:1; the solubilizer is composed of Tween-60 and polyglyceryl-10 laurate in a mass ratio of 1:1; the citronella extract and the viola yedoensis extract are prepared according to the method in section I above; the Houttuynia cordata / Scutellaria baicalensis extract is extract 2#.

[0076] Specific preparation method: heat water to 60℃, add solubilizer, stir at 100 rpm for 10 minutes to obtain mixture one; heat the solvent to 47℃, add salicylic acid, azelaic acid, citronella extract, viola yedoensis extract and houttuynia cordata / scutellaria extract, stir at 120 rpm for 10 minutes to obtain mixture two; add mixture two to mixture one, continue to stir at 220 rpm for 25 minutes, sterilize to obtain the composition.

[0077] 2. Preparation of hair preparations

[0078] Rosemary extract: Fufeng Snoot Biotechnology Co., Ltd. Avocado oil: Tuofa (Guangzhou) Biotechnology Co., Ltd. Camellia seed oil: Wuhan Huaxiang Kejebioengineering Technology Co., Ltd. Ginseng extract: Shenzhen Xingkeyue Biotechnology Co., Ltd.

[0079] Hair preparation 1

[0080] Raw material composition: 10% composition 1, 3% glycerol, 6% alkyl glucoside APG 0814, 4% cocamidopropyl betaine, 3.5% sodium lauroyl glutamate, 0.5% rosemary extract, 1.2% avocado oil, 1% camellia seed oil, 0.3% ginseng extract, 0.08% polyquaternium-10, 1.3% carbomer-941, 0.4% pH adjuster citric acid, 0.25% preservative phenoxyethanol and the balance water.

[0081] Preparation method: add water into the reaction kettle, heat to 60℃, add glycerol, alkyl glucoside APG 0814, cocamidopropyl betaine and sodium lauroyl glutamate, stir at 120 rpm for 20 minutes, then add avocado oil and camellia seed oil and continue to stir for 15 minutes, then add composition 1, rosemary extract, ginseng extract and polyquaternium-10 and continue to stir for 20 minutes, then add carbomer-941, pH adjuster and preservative and continue to stir for 3 minutes, stand at room temperature for aging, sterilize, fill, to obtain the hair preparation.

[0082] Hair preparation 2: compared with hair preparation 1, use composition 2 to replace composition 1 in hair preparation 1, and the others are the same as hair preparation 1.

[0083] Hair preparation 3: compared with hair preparation 1, no composition 1 is used, and water is used to make up, and the others are the same as hair preparation 1.

[0084] 18 volunteers aged 30-55 years old, with symptoms of scalp itching and oily hair, 9 males and 9 females, were randomly divided into 3 groups (Group 1 to Group 3), 6 people in each group, 3 males and 3 females in each group; Group 1 to Group 3 correspond to the use of hair preparations 1-3 respectively; usage: use once every 2 days, wash hair before taking a bath at night, specifically squeeze the preparation into the palm (3g for males and 6g for females), then rub and apply on the hair, then rinse with clean water; after 7 times of continuous use, evaluation is carried out.

[0085] The results show that in Group 1, the scalp itching of 5 volunteers disappeared, and 1 volunteer fed back that the scalp itching was significantly reduced; the oily hair of 6 volunteers was improved to a large extent. In Group 2, the scalp itching of 5 volunteers disappeared, and 1 volunteer fed back that the scalp itching was significantly reduced; the oily hair of 6 volunteers was improved to a large extent. In Group 3, only 2 volunteers fed back that the scalp itching and oily hair were slightly improved, and the other 4 volunteers fed back that the scalp itching and oily hair were basically unchanged.

[0086] According to the above test results, it can be known that the hair preparation prepared by using the composition has good effects of relieving itching and improving oily hair.

Claims

1. A composition for killing mites and relieving inflammation of the scalp, characterized by comprising, The raw materials include: salicylic acid, azelaic acid, citronella extract, viola philippica extract, houttuynia cordata / scutellaria baicalensis extract, solvent, solubilizer and water.

2. The composition of claim 1, wherein, The solvent includes at least one of ethylene glycol, propylene glycol, butylene glycol and glycerol.

3. The composition of claim 1, wherein, The solubilizer includes at least one of tween-20, tween-40 and polyglyceryl-10 laurate.

4. The composition of claim 1, wherein, The composition includes, by weight percentage, 0.05-0.3% salicylic acid, 0.05-0.3% azelaic acid, 0.5-2.5% citronella extract, 0.5-2.5% viola philippica extract, 0.7-4.5% houttuynia cordata / scutellaria baicalensis extract, 15-30% solvent, 5-10% solubilizer and the balance water.

5. The composition of claim 1, wherein, The preparation method of the citronella extract includes selecting 80-95wt% ethanol solution for extraction.

6. The composition of claim 1, wherein, The preparation method of the viola philippica extract includes selecting 70-85wt% ethanol solution for extraction.

7. The composition of claim 1, wherein, The preparation method of the houttuynia cordata / scutellaria baicalensis extract includes selecting 1:2-3.5 by weight ratio of houttuynia cordata and scutellaria baicalensis, extracting with 50-75wt% ethanol solution, then filtering, concentrating, extracting with an extractant composed of an organic solvent and water, and taking the organic solvent for concentration; wherein the organic solvent is chloroform and cyclohexane in a volume ratio of 1:0.5-1.

3.

8. A process for the preparation of a composition according to any one of claims 1 to 7, characterized in that, The method includes heating water, adding the solubilizer and stirring to obtain a mixture one; heating the solvent, adding salicylic acid, azelaic acid, citronella extract, viola philippica extract and houttuynia cordata / scutellaria baicalensis extract and stirring to obtain a mixture two; adding the mixture two to the mixture one and continuing to stir, sterilizing to obtain the composition.

9. A hair preparation for removing mites and alleviating inflammation of the scalp, characterized by comprising: The composition includes, by weight percentage, 1-15% of the composition according to any one of claims 1-7, 2-4% glycerol, 4-8% alkyl glucoside, 3-6% cocamidopropyl betaine, 2-4.5% sodium lauroyl glutamate, 0.1-0.8% rosemary extract, 0.5-2% avocado oil, 0.5-1.5% camellia seed oil, 0.1-1% ginseng extract, 0.01-0.2% polyquaternium-10, 0.5-2% carbomer-941, 0.1-0.4% pH adjuster, 0.1-0.3% preservative and the balance water.

10. A process for the preparation of a preparation according to claim 9, characterized in that, The method includes adding water into a container, heating, adding the remaining raw materials and stirring.

Images