Mild moisturizing skin care composition and application thereof

Abstract

The invention discloses a mild moisturizing skin care composition and application thereof, and belongs to the technical field of cosmetics. The skin care composition provided by the invention comprises an emulsifier, an auxiliary agent, grease and a humectant, the emulsifier comprises arachidinol glucoside and polyglycerol fatty acid ester; the auxiliary agent comprises ceramide EOP, stearic acid and phytosterol; the grease comprises first grease, second grease and third grease, the first grease comprises liquid grease, the second grease comprises natural semi-solid grease with the melting point of 25-52 DEG C, and the third grease comprises at least one of cetostearyl alcohol and behenyl alcohol; the humectant comprises a polyhydric alcohol. According to the skin care composition, specific components are selected and compounded with one another, so that a skin care product prepared from the skin care composition has excellent effects of rapidly relieving skin dryness and moisturizing for a long time, and the skin barrier capacity can be effectively improved; in addition, the obtained skin care product is high in tenderness and excellent in storage stability and use experience.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and particularly relates to a mild moisturizing skin care composition and application thereof. BACKGROUND

[0002] Children with sensitive skin, such as patients with atopic dermatitis, have impaired skin barrier, increased trans-epidermal water loss, extremely dry and sensitive skin, and high requirements for product safety. The moisturizing effect of skin care products is positively correlated with the type and amount of moisturizing agent, functional moisturizing agent, and barrier ability of the system. Different moisturizing combinations have different moisture absorption capacities, and the greater the moisture absorption capacity, the better the moisturizing effect; functional moisturizing agents can promote the generation of natural moisturizing factors, enhance the expression of aquaporin, and improve the moisturizing effect; the barrier effect of the system can effectively form a closed film on the skin surface, significantly reduce the rate of water loss from the skin surface to the environment, and the construction of a powerful barrier system is the key to "locking" water and amplifying the moisturizing effect. The barrier ability of the system is closely related to different oils, emulsifiers and combinations.

[0003] In order to improve the moisturizing effect of skin care products in the prior art, the formula design usually increases the type and amount of moisturizing agent, adds functional moisturizing agent, etc., and ignores the barrier ability design of the product, but this often accompanies the increase of product irritation, which is not conducive to the use of sensitive skin people, especially for the tender skin of babies. SUMMARY

[0004] The present application aims to overcome the shortcomings of the prior art, and ingeniously compounding emulsifiers, additives, oils and moisturizing agents by E (Emulsification System, emulsion system) L (Lipid Design, lipid design) M (Moisturizing System, moisturizing system) formula design technology, to provide a mild moisturizing skin care composition and application thereof, which has excellent rapid relief of skin dryness and long-term moisturizing effect, long-term improvement of skin barrier ability effect, and excellent mildness, product storage stability and good use experience.

[0005] To achieve the above-mentioned purpose, in the first aspect of the present application, the present application provides a mild moisturizing skin care composition, which comprises emulsifiers, additives, oils and moisturizing agents;

[0006] The emulsifiers include arachin glucoside and polyglycerol fatty acid ester;

[0007] The additives include ceramide EOP, stearic acid and phytosterol;

[0008] The oil and fat includes a first oil and fat, a second oil and fat and a third oil and fat, the first oil and fat includes a liquid oil and fat, the second oil and fat includes a natural semi-solid fat with a melting point of 25-52℃, and the third oil and fat includes at least one of cetyl alcohol and behenyl alcohol.

[0009] The humectant includes a polyhydric alcohol.

[0010] The present application researches and finds that by selecting the emulsifier system, the auxiliary agent system, the oil and fat system and the humectant of the present application, the systems are mutually compounded, and the components in the system also have good mutual synergistic effect, so that the skin care product obtained by using the skin care composition of the present application has excellent rapid relief of dry skin and long-acting moisturizing effect, and can effectively improve the skin barrier ability; in addition, the obtained skin care product is mild and has excellent storage stability, can be effectively applied to sensitive skin and baby skin, and has excellent experience in use.

[0011] Specifically, the emulsifiers in the present application include arachidyl glucoside and polyglyceryl fatty acid ester, which are compounded based on the assembly behavior of the emulsifier molecular interface, can be arranged and embedded at the oil-water interface after compounding, promote the crosslinking of the emulsifier layer, strengthen the improvement of the interface film strength and thickness of the emulsification system, thereby improving the barrier effect, and also optimizing the skin barrier ability on the basis of improving the skin moisture content, and also improving the stability of the product. The auxiliary agent combination in the present application can further strengthen the interface film formed by the emulsifier, and can form a lamellar structure of skin-like lipid together with the emulsifier and the oil and fat, enhance the physical barrier function of the interface film, further improve the occlusivity to the skin, and thereby better improve the moisturizing property and enhance the skin barrier ability. The oil and fat can better form an internal phase with moderate softness and better compatibility with the emulsifier on the basis of the interface film formed by the emulsifier, strengthen the strength of the interface film, and improve the stability and good occlusivity of the film layer in the process of contacting and applying to the skin. The selection of the humectant can provide direct moisturizing effect under the cooperation of the emulsifier, the auxiliary agent and the oil and fat, and the above-mentioned combination applied to the subsequent skin care product can improve the excellent moisturizing effect of the skin care product, and also has good application effect and product stability.

[0012] As a preferred embodiment of the skin care composition of the present application, the skin care composition includes the following components by mass: emulsifier 1-9 parts, auxiliary agent 0.03-0.5 parts, oil and fat 3-50 parts, and humectant 1-5 parts.

[0013] As a preferred embodiment of the skin care composition of the present application, the skin care composition includes the following components by mass: emulsifier 3-6 parts, auxiliary agent 0.1-0.2 parts, oil and fat 10-18 parts, and humectant 1-4 parts.

[0014] The present application researches and finds that the mass fraction of emulsifiers, adjuvants, oils and moisturizers in the skin care composition can affect the interaction between components. When the mass fraction of components is further selected within the above range, the emulsifier can form an interfacial film faster and better, the adjuvant can better improve the stability and strength of the interfacial film, the oil can form an internal phase with moderate softness and better compatibility with the emulsifier under the cooperation of the emulsifier and the adjuvant, strengthen the strength of the interfacial film, improve the stability and good sealing of the film during skin contact and application, help the moisturizer to play a role with less addition amount and reduce the water loss of the skin itself. That is, when the mass fraction of emulsifiers, adjuvants, oils and moisturizers in the skin care composition is further selected within the above range, the skin care composition obtained has excellent rapid relief of dry skin and long-acting moisturizing effect when applied to skin care products, and can also effectively improve the skin barrier ability, maintain good storage stability and mildness of the product.

[0015] As a preferred embodiment of the skin care composition of the present application, the mass percentage of the oil in the total mass of the skin care composition is 32-83%.

[0016] For example, the mass percentage of the oil in the total mass of the skin care composition can be any point value or any two-point range value between 32-83%, such as 32%, 35%, 40%, 42%, 45%, 50%, 52%, 54%, 56%, 58%, 60%, 62%, 64%, 66%, 68%, 70%, 72%, 75%, 80%, 83%, etc.

[0017] Preferably, the mass percentage of the oil in the total mass of the skin care composition is 64-70%.

[0018] More preferably, the mass percentage of the oil in the total mass of the skin care composition is 64-66%.

[0019] The present application researches and finds that the mass percentage of the oil in the skin care composition not only affects the formation of the oil film, but also affects the strength of the interfacial film formed by the emulsifier, and also affects the interaction with the moisturizer; when the mass percentage of the oil in the skin care composition is further selected within the above range, the subsequent prepared skin care product has better sealing effect, more excellent moisturizing effect, and can better improve the skin barrier ability and the stability of the product.

[0020] As a preferred embodiment of the skin care composition of the present application, the mass percentage of the adjuvant in the total mass of the skin care composition is 0.05-5.3%.

[0021] Exemplarily, the mass percentage of the auxiliary agent can be any point value or any two-point range value between 0.05-5.3% based on the total mass of the skin care composition, such as 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.5%, 0.8%, 1.0%, 1.2%, 1.3%, 1.4%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.3%, and the like.

[0022] Preferably, the mass percentage of the auxiliary agent is 0.4-1.4% based on the total mass of the skin care composition.

[0023] More preferably, the mass percentage of the auxiliary agent is 0.7-0.8% based on the total mass of the skin care composition.

[0024] The present application research found that by further selecting the mass percentage of the auxiliary agent in the above range, the stability of the interfacial film formed by the emulsifier can be better improved, the sealing property and stability of the product are improved, thereby the moisturizing performance of the product and the skin barrier ability are improved, and the auxiliary agent in the above addition amount range can make the product have excellent mildness.

[0025] As a preferred embodiment of the skin care composition of the present application, the mass ratio of the emulsifier to the oil is 1:(3-10).

[0026] Exemplarily, the mass ratio of the emulsifier to the oil can be any point value or any two-point range value between 1:(3-10), such as 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, and the like.

[0027] Preferably, the mass ratio of the emulsifier to the oil is 1:(3-8).

[0028] More preferably, the mass ratio of the emulsifier to the oil is 1:(3-5.56).

[0029] Further preferably, the mass ratio of the emulsifier to the oil is 1:(3.2-3.3).

[0030] The present application research found that the mass ratio of the emulsifier to the oil will affect the moisturizing effect of the product on the skin and the stability of the product itself, and also affect the mildness of the product, when the mass ratio of the emulsifier to the oil is further selected in the above range, the comprehensive performance of the obtained product is better.

[0031] As a preferred embodiment of the skin care composition of the present application, in the emulsifier, the mass ratio of arachinyl alcohol glucoside to polyglycerol fatty acid ester is (2-6):(0.01-1.5).

[0032] Exemplarily, in the emulsifier, the mass ratio of arachidyl glucoside and polyglyceryl fatty acid ester can be any point value or any two-point range value between (2-6):(0.01-1.5), such as 2:0.01, 2:0.1, 2:0.3, 2:0.5, 2:0.8, 2:1, 2:1.2, 2:1.5, 4:0.01, 4:0.1, 4:0.3, 4:0.5, 4:0.8, 4:1, 4:1.2, 4:1.5, 6:0.01, 6:0.1, 6:0.3, 6:0.5, 6:0.8, 6:1, 6:1.2, 6:1.5, and the like.

[0033] The present application researches and finds that when the mass ratio of arachidyl glucoside and polyglyceryl fatty acid ester in the emulsifier is further selected within the above range, the comprehensive performance of the product obtained is more excellent.

[0034] Preferably, in the emulsifier, the mass ratio of arachidyl glucoside and polyglyceryl fatty acid ester is (3-4):(0.8-1).

[0035] As a preferred embodiment of the skin care composition of the present application, in the auxiliary agent, the mass ratio of ceramide EOP, stearic acid and phytosterol is ceramide EOP:stearic acid:phytosterol=3:(0.5-1.5):(0.5-1.5).

[0036] Exemplarily, in the auxiliary agent, the mass ratio of ceramide EOP, stearic acid and phytosterol can be any point value or any two-point range value between ceramide EOP:stearic acid:phytosterol=3:(0.5-1.5):(0.5-1.5), such as 3:0.5:0.5, 3:0.5:1, 3:0.5:1.5, 3:1:0.5, 3:1:1, 3:1:1.5, 3:1.5:0.5, 3:1.5:1, 3:1.5:1.5, and the like.

[0037] The present application researches and finds that in the auxiliary agent, the long-chain saturated fatty acid of ceramide EOP can promote the close arrangement of molecules to form a rigid interfacial film; the carboxylic acid group of stearic acid can form hydrogen bonds with the water phase to stabilize the interfacial film; the structure of phytosterols can be well anchored at the oil-water interface to reduce the fluidity of the interfacial film; when the three are compounded in the above mass ratio range, the stability of the interfacial film obtained is more excellent and the strength is higher; thereby the subsequent prepared skin care product has more excellent rapid relief of dry skin and long-acting moisturizing effect, more excellent storage stability and better ability to improve skin barrier, and is also more mild.

[0038] Preferably, in the auxiliary agent, the mass ratio of ceramide EOP, stearic acid and phytosterol is ceramide EOP:stearic acid:phytosterol=3:(0.8-1.2):(0.8-1.2).

[0039] As a preferred embodiment of the skin care composition of the present application, the polyglyceryl fatty acid ester comprises at least one of polyglyceryl-3 diisostearate, polyglyceryl-4 isostearate, polyglyceryl-6 distearate.

[0040] Preferably, the polyglyceryl fatty acid ester is polyglyceryl-6 distearate.

[0041] The present application finds that the type of polyglyceryl fatty acid ester, mainly the difference in different degrees of polymerization, will affect its own HLB value, and will also affect its interaction with arachidyl glucoside; when further selecting polyglyceryl fatty acid ester as the above type of substance, it can better form an interface film, and can emulsify more oil, thereby improving the moisturizing property, stability and mildness of the product.

[0042] As a preferred embodiment of the skin care composition of the present application, the phytosteryl includes at least one of beta-sitosterol, brassica campestris sterol, phytosteryl australi oil acid ester.

[0043] Preferably, the phytosteryl includes brassica campestris sterol.

[0044] The present application finds that the type of phytosteryl will affect its interaction with ceramide EOP and stearic acid, and further affect the effect of the auxiliary on the emulsifier and oil; when further selecting phytosteryl as the above type of substance, it can help the emulsifier to emulsify more oil, and can better improve the stability and strength of the interface film after emulsification, thereby improving the moisturizing property, stability and mildness of the product.

[0045] As a preferred embodiment of the skin care composition of the present application, the liquid oil includes plant liquid oil and synthetic liquid oil.

[0046] As a preferred embodiment of the skin care composition of the present application, the plant liquid oil includes at least one of perilla seed oil, white pool flower seed oil, sunflower seed oil, milk thistle seed oil, sea buckthorn fruit oil, borage oil, rice bran oil, and squalane.

[0047] As a preferred embodiment of the skin care composition of the present application, the synthetic liquid oil includes at least one of caprylic acid / capric acid triglyceride, dimethicone, glyceryl tri(ethylhexanoate), pentaerythritol tetra(ethylhexanoate).

[0048] As a preferred embodiment of the skin care composition of the present application, the natural semi-solid fat with a melting point of 25-52℃ includes at least one of avocado tree fat, theobroma grandiflorum seed fat, jojoba ester, and lupine star fruit brown seed fat.

[0049] The present application researches and finds that by selecting the above-mentioned plant liquid oil, synthetic liquid oil and natural semi-solid fat, the product can be better matched with the third oil, has excellent formula stability while improving the good sealing performance of the product, does not have the problem of low-temperature roughness, and has good use feeling.

[0050] As a preferred embodiment of the skin care composition of the present application, the mass percentage of oleic acid in the plant liquid oil is ≤20%.

[0051] Exemplarily, the mass percentage of oleic acid in the first oil can be any point value or any two-point range value between ≤20%, such as 1%, 3%, 5%, 8%, 10%, 12%, 15%, 18%, 20%, etc.

[0052] The present application researches and finds that when the liquid oil is selected to include plant liquid oil and the content of oleic acid in the plant liquid oil is further controlled, the skin barrier can be better protected, and the product has good repair effect and stability.

[0053] As a preferred embodiment of the skin care composition of the present application, the mass ratio of the first oil, the second oil and the third oil in the oil is first oil: second oil: third oil = (2-4): (1-5): (1-4).

[0054] Exemplarily, the mass ratio of the first oil, the second oil and the third oil in the oil can be 2:1:1, 2:1:2, 2:1:3, 2:1:4, 2:5:1, 2:5:2, 2:5:3, 2:5:4, 4:1:1, 4:1:2, 4:1:3, 4:1:4, 4:5:1, 4:5:2, 4:5:3, 4:5:4, etc.

[0055] The present application researches and finds that when the first oil, the second oil and the third oil are compounded in different mass ratios, not only the emulsification effect under the emulsifier is affected, thereby affecting the interface film strength and stability, and further affecting the moisturizing effect and storage stability of the product, but also the problem of poor use experience caused by oil stacking is avoided; when the mass ratio of the first oil, the second oil and the third oil is further selected within the above-mentioned range, the comprehensive effect of the obtained product is more excellent.

[0056] Preferably, the mass ratio of the first oil, the second oil and the third oil in the oil is first oil: second oil: third oil = 2: (3-4): (2-3).

[0057] In the second aspect of the present application, the present application provides the use of the skin care composition in the preparation of skin care products.

[0058] The skin care composition provided by the application has good rapid relief of skin dryness and long-acting moisturizing effect, good storage stability and excellent ability to improve skin barrier, and the obtained skin care composition is mild and non-irritating, and can be widely applied in the preparation of skin care products, and the obtained skin care products have good moisturizing effect, skin barrier enhancement effect and mild and non-irritating characteristics.

[0059] As a preferred embodiment of the application, the skin care product includes any one of essence milk, cream, body milk.

[0060] In the third aspect of the application, the application provides a skin care product, which comprises the following components by mass percentage: 35-55% of the skin care composition of the application, 0.02-0.1% of a chelating agent, 0.05-1% of a thickening agent, 0.05-0.5% of a co-emulsifier, 0.4-0.6% of hexylene glycol, 0.4-0.6% of p-hydroxyacetophenone, and the balance of water.

[0061] As a preferred embodiment of the skin care product of the application, the chelating agent includes disodium EDTA.

[0062] As a preferred embodiment of the skin care product of the application, the thickening agent includes at least one of xanthan gum, microbacterial gum, acryloyldimethyltauramide / VP copolymer, and hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer.

[0063] As a preferred embodiment of the skin care product of the application, the co-emulsifier includes at least one of hydrogenated lecithin and hydrogenated phosphatidylcholine.

[0064] Compared with the prior art, the application has the following beneficial effects:

[0065] The application selects specific emulsifier systems, auxiliary systems, oil systems and moisturizing agents, and the systems are compounded with each other, and the components in the system also have good mutual synergistic effect, so that the skin care product obtained from the skin care composition of the application has excellent rapid relief of skin dryness and long-acting moisturizing effect, and can effectively improve the skin barrier ability; in addition, the obtained skin care product is mild, has excellent storage stability and use experience. BRIEF DESCRIPTION OF DRAWINGS

[0066] Figure 1 It is a stimulation test result graph of application example 1 in effect example 2;

[0067] Figure 2 It is a stimulation test result graph of application example 7 in effect example 2;

[0068] Figure 3 It is a stimulation test result graph of comparative application example 13 in effect example 2. DETAILED DESCRIPTION

[0069] For the purpose of better illustrating the object, technical scheme and advantages of the present application, the present application will be further described in conjunction with specific examples.

[0070] The reagents, methods and equipment used in the present application are all conventional reagents, methods and equipment in the art unless otherwise specified; and the raw materials used in parallel experiments are the same batch of raw materials unless otherwise specified.

[0071] Emulsifier 1: a mixture of arachidyl glucoside and polyglyceryl-6 diisostearate in a mass ratio of 4:0.8;

[0072] Emulsifier 2: the difference from emulsifier 1 is that the mass ratio of arachidyl glucoside and polyglyceryl-6 diisostearate is 2:1.5;

[0073] Emulsifier 3: the difference from emulsifier 1 is that the mass ratio of arachidyl glucoside and polyglyceryl-6 diisostearate is 6:0.01;

[0074] Emulsifier 4: the difference from emulsifier 1 is that polyglyceryl-4 isostearate is used instead of polyglyceryl-6 diisostearate;

[0075] Emulsifier 5: arachidyl glucoside;

[0076] Emulsifier 6: polyglyceryl-6 diisostearate;

[0077] Emulsifier 7: the difference from emulsifier 1 is that cocoglycoside is used instead of arachidyl glucoside.

[0078] Adjuvant 1: a mixture of ceramide EOP, stearic acid and phytosterol [BRASSICA CAMPESTRIS sterols (purchased from BASF (China) Co., Ltd.)] in a mass ratio of 3:1:1;

[0079] Adjuvant 2: the difference from adjuvant 1 is that the mass ratio of ceramide EOP, stearic acid and phytosterol is 1:3:1;

[0080] Adjuvant 3: the difference from adjuvant 1 is that BRASSICA CAMPESTRIS sterols are replaced by phytosterol macadamiate PHYTOSTERYL MACADAMIATE;

[0081] Adjuvant 4: the difference from adjuvant 1 is that ceramide EOP is not added;

[0082] Adjuvant 5: the difference from adjuvant 1 is that stearic acid is not added;

[0083] Adjuvant 6: the difference from adjuvant 1 is that phytosterol is not added;

[0084] Adjuvant 7: the difference from Adjuvant 1 is that ceramide NP is used instead of ceramide EOP.

[0085] Oil 1: a mixture of a first oil (a mixture of sunflower seed oil and caprylic / capric triglyceride in a ratio of 1:4, wherein the sunflower seed oil has an oleic acid content of ≤20%, purchased from Cargill, Incorporated), a second oil (Theobroma grandiflorum seed butter, melting point of 25-37℃, purchased from Clariant Chemicals (Shanghai) Co., Ltd.) and a third oil (behenyl alcohol) in a mass ratio of 2:4:3;

[0086] Oil 2: the difference from Oil 1 is that the mass ratio of the first oil, the second oil and the third oil is 4:1:1;

[0087] Oil 3: the difference from Oil 1 is that the first oil is perilla seed oil with an oleic acid content of ≤10% (purchased from Jiangxi Xinsen Natural Plant Oil Co., Ltd.);

[0088] Oil 4: the difference from Oil 1 is that the first oil is sea buckthorn oil with an oleic acid content of ≤10% (purchased from Draco Nature Product);

[0089] Oil 5: the difference from Oil 1 is that cetyl stearyl alcohol is used instead of behenyl alcohol;

[0090] Oil 6: the difference from Oil 1 is that the first oil is not added;

[0091] Oil 7: the difference from Oil 1 is that the second oil is not added;

[0092] Oil 8: the difference from Oil 1 is that the third oil is not added;

[0093] Oil 9: the difference from Oil 1 is that stearyl alcohol is used instead of behenyl alcohol.

[0094] Moisturizer 1: glycerol;

[0095] Moisturizer 2: a mixture of butylene glycol and glycerol in a mass ratio of 1:1;

[0096] Moisturizer 3: trehalose.

[0097] Examples 1-8 and Comparative Example 1

[0098] The examples and comparative examples of the present application provide a skin care composition, the components (mass parts) of which are shown in Table 1; wherein W1 represents the mass percentage of oil in the total mass parts of the skin care composition, W2 represents the mass percentage of adjuvant in the total mass parts of the skin care composition; and W3 represents the mass ratio of emulsifier to oil.

[0099] Table 1

[0100] Emulsifier 1 Adjuvant 1 Oil 1 Humectant 1 W1 / ％ W2 / ％ W3 Example 1 4 0.15 13 3 65 0.7 1:3.25 Example 2 3 0.2 10 1 70 1.4 1:3.30 Example 3 6 0.1 18 4 64 0.4 1:3.00 Example 4 1 0.5 3 5 32 5.3 1:3.00 Example 5 9 0.03 50 1 83 0.05 1:5.56 Example 6 3 0.15 18 3 75 0.6 1:6.00 Example 7 0.5 0.15 1.5 6 18 1.8 1:3.00 Example 8 4 2.0 13 0.5 67 10.3 1:3.25 Comparative Example 1 4 0 13 3 65 0 1:3.25

[0101] Example 9

[0102] An embodiment of the present application provides a skin care composition, the only difference between the skin care composition and Example 1 is that emulsifier 2 is used instead of emulsifier 1.

[0103] Example 10

[0104] An embodiment of the present application provides a skin care composition, the only difference between the skin care composition and Example 1 is that emulsifier 3 is used instead of emulsifier 1.

[0105] Example 11

[0106] An embodiment of the present application provides a skin care composition, the only difference between the skin care composition and Example 1 is that emulsifier 4 is used instead of emulsifier 1.

[0107] Example 12

[0108] An embodiment of the present application provides a skin care composition, the only difference between the skin care composition and Example 1 is that adjuvant 2 is used instead of adjuvant 1.

[0109] Example 13

[0110] An embodiment of the present application provides a skin care composition, the only difference between the skin care composition and Example 1 is that adjuvant 3 is used instead of adjuvant 1.

[0111] Example 14

[0112] An embodiment of the present application provides a skin care composition, the only difference between the skin care composition and Example 1 is that oil 2 is used instead of oil 1.

[0113] Example 15

[0114] An embodiment of the present application provides a skin care composition, the only difference between the skin care composition and Example 1 is that oil 3 is used instead of oil 1.

[0115] Example 16

[0116] An embodiment of the present application provides a skin care composition, the only difference between the skin care composition and Example 1 is that oil 4 is used instead of oil 1.

[0117] Example 17

[0118] An embodiment of the present application provides a skin care composition, the only difference between the skin care composition and Example 1 is that oil 5 is used instead of oil 1.

[0119] Example 18

[0120] The present example provides a skin care composition which differs from Example 1 only in that humectant 2 is used in place of humectant 1.

[0121] Comparative Example 2

[0122] The present comparative example provides a skin care composition which differs from Example 1 only in that emulsifier 5 is used in place of emulsifier 1.

[0123] Comparative Example 3

[0124] The present comparative example provides a skin care composition which differs from Example 1 only in that emulsifier 6 is used in place of emulsifier 1.

[0125] Comparative Example 4

[0126] The present comparative example provides a skin care composition which differs from Example 1 only in that emulsifier 7 is used in place of emulsifier 1.

[0127] Comparative Example 5

[0128] The present comparative example provides a skin care composition which differs from Example 1 only in that adjuvant 4 is used in place of adjuvant 1.

[0129] Comparative Example 6

[0130] The present comparative example provides a skin care composition which differs from Example 1 only in that adjuvant 5 is used in place of adjuvant 1.

[0131] Comparative Example 7

[0132] The present comparative example provides a skin care composition which differs from Example 1 only in that adjuvant 6 is used in place of adjuvant 1.

[0133] Comparative Example 8

[0134] The present comparative example provides a skin care composition which differs from Example 1 only in that adjuvant 7 is used in place of adjuvant 1.

[0135] Comparative Example 9

[0136] The present comparative example provides a skin care composition which differs from Example 1 only in that oil 6 is used in place of oil 1.

[0137] Comparative Example 10

[0138] The present comparative example provides a skin care composition which differs from Example 1 only in that oil 7 is used in place of oil 1.

[0139] Comparative Example 11

[0140] The present comparative example provides a skin care composition, the only difference between which and Example 1 is that oil 8 is used instead of oil 1.

[0141] Comparative Example 12

[0142] The present comparative example provides a skin care composition, the only difference between which and Example 1 is that oil 9 is used instead of oil 1.

[0143] Comparative Example 13

[0144] The present comparative example provides a skin care composition, the only difference between which and Example 1 is that moisturizer 3 is used instead of moisturizer 1.

[0145] Application Examples 1-19, Comparative Application Examples 1-13, and a Blank Application Example

[0146] The present application examples, comparative application examples, and a blank application example provide a skin care product, the components (mass percent) of which are shown in Table 2; wherein the skin care compositions used in Application Examples 1-18 are respectively the skin care compositions prepared in Examples 1-18, such as the skin care composition in Example 1 is used in Application Example 1, the skin care composition in Example 2 is used in Application Example 2, and so on; the skin care compositions used in Comparative Application Examples 1-13 are respectively the skin care compositions prepared in Comparative Examples 1-13; the skin care composition used in Application Example 19 is the skin care composition prepared in Example 1;

[0147] Table 2

[0148]

[0149]

[0150] The preparation method of the skin care product provided by Application Example 1 includes the following steps:

[0151] (1) Put the emulsifier, auxiliary agent, and oil into an oil phase pot, and heat to 85-90°C under stirring to prepare an oil phase;

[0152] (2) Put the water, thickening agent, chelating agent, and moisturizer into a water phase pot, and heat to 85°C under stirring to prepare a water phase;

[0153] (3) Add the oil phase into the water phase, stir until uniform, vacuumize, and then start the medium-high speed homogenization treatment for 10 minutes;

[0154] (4) Open the cooling water, slowly cool to 40-45℃, add the remaining material, stir evenly, take sample and pass the inspection, then discharge, and the skin care product is obtained.

[0155] The preparation method of the skin care product provided in Application Example 2-19, Comparative Application Example 1-13 and Blank Application Example is consistent with that of Application Example 1, and no related components are added.

[0156] Effect Example 1

[0157] The effect of the skin care product prepared in the application example, the comparative application example and the blank application example is explored.

[0158] 1, Barrier effect

[0159] The barrier effect of the sample is tested by using a physical model:

[0160] Test method: The physical model is composed of a circular transfer filter paper with a diameter of 5 cm and a tetrafluoroethylene gasket, and is placed in a constant temperature and humidity test chamber under the temperature and humidity conditions set by the chamber (temperature 30℃, humidity 50%). The weight of the blank physical model is recorded as m0. The physical model coated with a certain amount of test sample (1.2g sample) is placed on a weighing bottle containing a certain amount of purified water (20g), and is placed in a sieve with the same mesh size (200 mesh) in a constant temperature and humidity chamber. After 24h, the physical model is taken out and weighed, and the weight is recorded as m1. The physical model is placed in an oven at a temperature of 60℃ and dried for 16h. After drying, the physical model is taken out and weighed by using a thousandth balance and recorded, and the weight is recorded as m2. The barrier effect is represented by w, and the calculation formula is as follows:

[0161]

[0162] The results are shown in Table 3.

[0163] 2, Long-term moisturizing effect and effect of improving skin barrier ability

[0164] The moisture content of the stratum corneum (MMV value) represents the long-term moisturizing effect, and the transdermal water loss (TWEL value) represents the repair effect.

[0165] The skin care products prepared in the application example and the comparative application example are respectively taken, and sensitive skin (TEWL≥20g / hm 2 ) is used as the subject (6 people in each group) to test the moisture content of the stratum corneum and the transdermal water loss. The test area (face) of the subject cannot be coated with any product on the day of visit, and after washing the face, the subject is placed in a constant temperature and humidity room with a temperature of 21±1℃ and a humidity of 50±10% for 20min. The skin transdermal water loss probe TM Hex (Courage + Khazaka) and moisture measurement probe CM825 measured the initial TEWL value and MMV value of the left and right faces of each volunteer, and took the average value. The subjects used the skin care product continuously for 28 days, and the post-use TEWL value and MMV value of the facial skin were measured again.

[0166] TEWL value improvement rate (%) = (initial TEWL value - post-use TEWL value) / initial TEWL value x 100%;

[0167] MMV value improvement rate (%) = (post-use MMV value - initial MMV value) / initial MMV value x 100%;

[0168] The greater the TEWL value improvement rate, the stronger the skin barrier damage repair ability of the emollient; the greater the MMV value improvement rate, the better the long-acting moisturizing effect of the emollient. The results obtained are shown in Table 3.

[0169] Table 3

[0170]

[0171]

[0172] As can be seen from Table 3, when the technical solution provided by the present application is used, the skin care product obtained has excellent rapid relief of skin dryness and long-acting moisturizing effect, and can effectively improve the skin barrier ability; specifically, the barrier effect w of the skin care product obtained is above 32.5%, and the TEWL value improvement rate and the MMV value improvement rate are above 20.2% and 38.5%, respectively.

[0173] As can be seen from application examples 1-8 and comparative application example 1, the mass parts of the components and whether a certain component is added have a significant effect on the product performance, and when the mass parts of the components are further selected within the range of the present application, the comprehensive effect of the product obtained is better; specifically, the barrier effect w of the skin care product obtained is above 40.2%, and the TEWL value improvement rate and the MMV value improvement rate are above 23.5% and 46.2%, respectively; when no auxiliary agent is added in comparative application example 1, the improvement ability of the product obtained on the skin barrier is significantly reduced, and the barrier effect is also significantly reduced.

[0174] As can be seen from application examples 1, application examples 9-11 and comparative application examples 2-4, the selection of the emulsifier has a greater effect on the barrier effect, long-acting moisturizing and repair effect; when only any one of the emulsifiers is added or is replaced by other substances, the effect of the present application cannot be achieved.

[0175] As can be seen from application example 1, application examples 12-13 and comparative application examples 5-8, the selection of the auxiliary agent also has a greater influence on the barrier effect, long-term moisturizing and repair effect; when any of the auxiliary agents is not added or is replaced by other substances, the barrier effect, long-term moisturizing and repair effect of the obtained product are obviously reduced.

[0176] As can be seen from application example 1, application examples 14-17 and comparative application examples 9-12, the selection of the oil has a greater influence on the barrier effect, long-term moisturizing and repair effect; when any of the oils is not added or is replaced by other substances, the barrier effect, long-term moisturizing and repair effect of the obtained product are obviously reduced.

[0177] As can be seen from application example 1, application example 18 and comparative application example 13, the selection of the moisturizing agent directly influences the moisturizing effect, and has a relatively smaller influence on the barrier effect and repair effect.

[0178] Effect example 2

[0179] The effect example of the present application explores the irritability of the skin care products prepared from the application examples, comparative application examples and blank application examples, including the following steps:

[0180] The chicken embryo chorioallantoic membrane experiment is adopted, including the following steps: SPF grade chicken embryos are incubated in an incubator at a temperature of 37.5℃±0.5℃, a humidity of 65% and a rotation frequency of 5 times / h for 9 days, and after being taken out, the air chamber position is marked, the eggshell is carefully peeled off, the white egg membrane is exposed, the egg membrane is moistened with 1mL of normal saline, and the egg membrane is carefully removed to avoid damage to the blood vessel membrane. A Teflon ring is placed at the yolk position of the chicken embryo, the chicken embryo is placed under a stereomicroscope to record a photo before being loaded, an appropriate amount of emollient is added to the Teflon ring, and a photo at 30 minutes is recorded, and 6 chicken embryos are prepared in parallel for each sample.

[0181] Result evaluation: the irritability of the sample is scored according to the bleeding, coagulation and vascular lysis phenomena of the blood vessels, and 0, 1, 2 and 3 points are respectively given according to no bleeding, mild bleeding, moderate bleeding and severe bleeding; 0, 1, 2 and 3 points are respectively given according to no coagulation, mild coagulation, moderate coagulation and severe coagulation; 0, 1, 2 and 3 points are respectively given according to no vascular lysis, mild vascular lysis, moderate vascular lysis and severe vascular lysis.

[0182] The end point score ES is calculated by the formula: ES = the total sum of the scores corresponding to the degrees of bleeding, coagulation and vascular lysis observed in 6 chicken embryos / 3;

[0183] The scoring table is shown in Table 4, and the obtained results are shown in Table 5.

[0184] Table 4

[0185] End-point score Irritation classification ES < 12 No / mild irritation 12 < ES < 16 Moderate irritation ES > 16 Severe irritation

[0186] Table 5

[0187]

[0188]

[0189] As can be seen from Table 5, the skin care product obtained by using the technical scheme of the present application has high mildness; the moisturizing agent in application example 7 has a mass percentage in the skin care composition that is too high in the range of addition, resulting in relatively high irritation; when the skin care composition in comparative application example 13 is changed in the moisturizing agent, the irritation of the obtained skin care product also significantly increases. Specifically, the photographed images of any one of the chicken embryos in application example 1, application example 7 and comparative application example 13 are shown in Figs. 1, 2 and 3, respectively. Figures 1-3

[0190] Effect Example 3

[0191] The present application effect example explores the stability of the skin care products prepared by the application examples, comparative application examples and blank application examples, including the following steps:

[0192] The skin care products prepared by the application examples and comparative application examples are subjected to heat resistance, cold resistance, cold and heat cycle, light and centrifugal tests. The index requirements of heat resistance are: (40±1)℃ for 3 months, no delamination phenomenon after recovery to room temperature; the index requirements of cold resistance are: -15℃ for 1 month, no delamination phenomenon after recovery to room temperature; cold and heat cycle (-15℃~25℃~45℃) for 3 cycles without delamination; light (light aging box) for 1 month without discoloration and off-flavor; the index requirements of centrifugal test are: 3000r / m, 30min without delamination; the obtained results are shown in Table 6.

[0193] Table 6

[0194]

[0195]

[0196] As can be seen from Table 6, the stability of the skin care product obtained by using the technical scheme provided by the present application is excellent, while the stability of the non-inventive scheme will appear a certain degree of abnormality.

[0197] Finally, it should be noted that the above examples are to illustrate the technical scheme of the present application, not to limit the protection scope of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical scheme of the present application can be modified or replaced by equivalents without departing from the essence and scope of the technical scheme of the present application.​

Claims

1. A mild moisturizing skin care composition characterized in that, The skin care composition comprises an emulsifier, an auxiliary agent, an oil and a humectant; The emulsifier comprises arachidyl glucoside and polyglyceryl fatty acid ester; The auxiliary agent comprises ceramide EOP, stearic acid and phytosterol; The oil comprises a first oil, a second oil and a third oil, the first oil comprises a liquid oil, the second oil comprises a natural semi-solid fat with a melting point of 25-52℃, and the third oil comprises at least one of cetylstearyl alcohol and behenyl alcohol; The humectant comprises a polyhydric alcohol.

2. The skin care composition of claim 1, wherein, The skin care composition comprises the following components by mass: 1-9 parts of the emulsifier, 0.03-0.5 parts of the auxiliary agent, 3-50 parts of the oil, and 1-5 parts of the humectant.

3. The skin care composition of claim 1, wherein The mass percentage of the oil in the total mass of the skin care composition is 32-83%; And / or, the mass percentage of the auxiliary agent in the total mass of the skin care composition is 0.05-5.3%; And / or, the mass ratio of the emulsifier to the oil is 1:(3.0-10); And / or, in the emulsifier, the mass ratio of arachidyl glucoside to polyglyceryl fatty acid ester is (2-6):(0.01-1.5); And / or, in the auxiliary agent, the mass ratio of ceramide EOP, stearic acid and phytosterol is ceramide EOP:stearic acid:phytosterol=3:(0.5-1.5):(0.5-1.5).

4. The skin care composition of claim 1, wherein The polyglyceryl fatty acid ester comprises at least one of polyglyceryl-3 diisostearate, polyglyceryl-4 isostearate and polyglyceryl-6 distearate; And / or, the phytosterol comprises at least one of β-sitosterol, brassicasterol and phytosterol macadamia nut oil ester.

5. The skin care composition of claim 1, wherein The liquid oil comprises a plant-derived liquid oil and a synthetic liquid oil.

6. The skin care composition of claim 5, wherein, The plant-derived liquid oil comprises at least one of perilla seed oil, meadowfoam seed oil, sunflower seed oil, milk thistle seed oil, sea buckthorn fruit oil, glasswort seed oil, rice bran oil and squalane; And / or, the synthetic liquid oil comprises at least one of caprylic / capric triglyceride, dimethicone, glyceryl tri(ethylhexanoate) and pentaerythrityl tetra(ethylhexanoate); And / or, the natural semi-solid fat with a melting point of 25-52℃ comprises at least one of butyrospermum fruit fat, theobroma grandiflorum seed fat, jojoba esters and vaccarum prunifolium seed fat.

7. The skin care composition of claim 5, wherein In the first oil, the mass ratio of the plant-derived liquid oil to the synthetic liquid oil is 1:(3-5); And / or, in the plant-derived liquid oil, the mass percentage of oleic acid is ≤20%.

8. The skin care composition of claim 1, wherein In the oil, the mass ratio of the first oil, the second oil and the third oil is first oil:second oil:third oil=(2-4):(1-5):(1-4).

9. Use of the skin care composition according to any one of claims 1-8 in the preparation of a skin care product.

10. A skin care product, characterized by, The skin care product comprises the following components by mass percentage: 35-55% of the skin care composition according to any one of claims 1-8, 0.02-0.1% of a chelating agent, 0.05-1% of a thickening agent, 0.05-0.5% of a co-emulsifier, 0.4-0.6% of hexylene glycol, 0.4-0.6% of p-hydroxyacetophenone, and the balance water.

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