Yao medicine composition for resisting inflammation and easing pain and preparation method thereof
By using a combination preparation process of *Smilax china*, *Senecio scandens*, *Polygonum cuspidatum*, and catechins, the adverse reactions of traditional anti-inflammatory and analgesic drugs and the poor stability of catechins have been solved, achieving a highly efficient and stable anti-inflammatory and analgesic effect.
Patent Information
- Application Number
- CN202511062471.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-31
- Publication Date
- 2025-11-07
AI Technical Summary
Existing anti-inflammatory and analgesic drugs often have adverse side effects such as gastrointestinal reactions and allergic reactions during use, and traditional Chinese medicine ingredients such as catechins have problems with poor stability and low utilization.
A Yao medicine composition was prepared by using a combination of *Smilax china*, *Senecio scandens*, *Polygonum cuspidatum*, and catechins, through a process of heating and reflux extraction, concentration, and spray drying, to form a paste powder with anti-inflammatory and analgesic effects.
It significantly reduces the degree of inflammation and swelling in the auricle of mice, increases the hot plate pain threshold, and reduces the number of painful writhing movements in mice induced by acetic acid. It has obvious anti-inflammatory and analgesic effects, and the manufacturing process is simple, low-cost, and the composition has stable quality.
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Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a Yao medicine composition for anti-inflammatory analgesia and a preparation method thereof. BACKGROUND
[0002] Inflammation and pain are common clinical symptoms, and anti-inflammatory analgesic drugs are used for treatment in clinic. At present, non-steroidal chemical drugs are commonly used for anti-inflammatory analgesia. However, the non-steroidal anti-inflammatory drugs with anti-inflammatory analgesic effect often cause a series of adverse reactions such as gastrointestinal reactions and allergic reactions in clinical use.
[0003] Arthritis refers to inflammatory diseases occurring in joints and surrounding tissues of human body, and the clinical manifestations are redness, swelling, heat, pain, dysfunction and joint deformity of joints. Common clinical arthritis mainly includes gouty arthritis, rheumatoid arthritis, osteoarthritis, traumatic arthritis and other joint manifestations of systemic diseases including systemic lupus erythematosus, tumors and blood diseases, which is one of common inflammatory diseases. The treatment drugs include non-steroidal anti-inflammatory drugs, steroid hormones, biological preparations and traditional Chinese medicines, among which the most widely used is the traditional Chinese medicine of rattan.
[0004] It is found that the anti-inflammatory effect of natural products mainly manifests that the inflammatory swelling or granuloma caused by chemical and physical stimulation can be significantly inhibited, and the permeability of capillaries in the abdominal cavity of mice after inflammation can be reduced, and the expression of inflammatory factors and genes can be inhibited. The analgesic effect of natural products can usually be represented as prolonging the pain threshold of various factors causing pain (such as heat pain, pressure pain and chemical stimulation). However, the anti-inflammatory analgesic drugs in clinic have certain toxic side effects or adverse reactions in addition to the anti-inflammatory and analgesic effects, such as coagulopathy, cardiovascular and cerebrovascular diseases, nephrotoxicity, liver damage, granulocytopenia and gastrointestinal damage.
[0005] Based on this, the present application provides a Yao medicine composition for anti-inflammatory analgesia and a preparation method thereof. SUMMARY
[0006] In order to solve the problems in the prior art, the present application provides a Yao medicine composition for anti-inflammatory analgesia and a preparation method thereof. In order to achieve the above purpose, the present application adopts the following technical solutions: A Yao medicine composition for anti-inflammatory analgesia is prepared from the following raw materials by weight: 30-40 parts of Fagara, 15-25 parts of Semecarpus, 1-4 parts of catechin and 12-18 parts of Giant Knotweed.
[0007] Preferably, the Fagara is 35-40 parts, the Semecarpus is 15-20 parts, the catechin is 2-3 parts and the Giant Knotweed is 15-18 parts.
[0008] Preferably, the Flemingia philippinensis 30-35 parts, the Loropetalum chinense 20-25 parts, the catechin 2-4 parts and the giant knotweed 12-15 parts.
[0009] The present application also provides a use of the Yao medicine composition for anti-inflammatory analgesia, which comprises the Yao medicine composition alone or in combination with other drugs.
[0010] Preferably, the preparation comprises any dosage form in pharmacy.
[0011] The present application further provides a preparation method of the Yao medicine composition for anti-inflammatory analgesia as described above, comprising the following steps: (1) measuring the above raw materials according to the weight fraction; and cutting the Flemingia philippinensis, the Loropetalum chinense and the giant knotweed respectively; (2) adding 8-16 times of water to the Flemingia philippinensis, the Loropetalum chinense and the giant knotweed for soaking, and heating for reflux extraction for a period of time; (3) filtering the extraction liquid; using 5 times of water to heat for reflux extraction of the filter residue for 20-30 min, and filtering; and combining the filtrates; (4) further concentrating the filtrate at 90℃ under reduced pressure into a concentrated liquid with a relative density of 1.05-1.25 g / ml; (5) cooling the concentrated liquid to room temperature, uniformly mixing with the catechin, and then reducing the pressure to concentrate the mixed liquid into a reformed extract with a relative density of 1.2-1.3 g / ml; (6) spray drying the extract to obtain a powder.
[0012] Preferably, in step (2), heating for reflux extraction is performed at 90-100℃ for 30-90 min.
[0013] Preferably, in step (3), heating for reflux extraction is performed for 25-30 min.
[0014] Preferably, in step (6), the inlet air temperature for spray drying is 160-165℃, the outlet air temperature is 90-100℃, and the air frequency is 30-40 Hz.
[0015] In particular, the present application provides a medicine with anti-inflammatory and / or analgesic effect, comprising the Yao medicine composition for anti-inflammatory analgesia as described above.
[0016] Flemingia polysaccharide is the dried root of Flemingia polyantha or Flemingia macrophylla, mainly distributed in South China, Central China, Southwest China and other places, which has the effects of expelling wind and dampness, relaxing muscles and tendons, strengthening muscles and bones, and relieving inflammation and pain, and is often used for the treatment of arthralgia such as rheumatic arthralgia. Flemingia polysaccharide is rich in chemical components, mainly composed of flavonoids, volatile oils, steroids and quinones, glycosides, proteins, saponins, organic acids and the like. Pharmacological studies have shown that Flemingia polysaccharide has the effects of analgesia, anti-inflammatory, anti-fatigue, antithrombotic, antitumor, blood lipid regulation, immune regulation and the like. Today, Flemingia polysaccharide has been used in the production of Chinese patent medicines for rheumatic arthralgia such as Huoluo Zhitong Pills, Compound Sea Snake and the like. In addition, Wang Mingjie et al. found that Flemingia polysaccharide oil needle therapy can significantly reduce the inflammatory damage of patients with arthritis and improve the joint function by using the volatile oil extracted from Flemingia polysaccharide combined with traditional acupuncture and through the effects of acupoint stimulation and drug efficacy transmission and penetration.
[0017] Semiliquidambar cathayesis is a monospecific plant of the genus Semiliquidambar in Hamamelidaceae, and the whole plant is used as a medicine. Semiliquidambar cathayesis was first recorded in Lingnan Caiyao Lu, has the effects of activating blood and resolving stasis, warming meridians and dispelling cold and dampness, and is used for treating limb paralysis, rheumatic lumbar and leg pain, traumatic injury, joint stiffness, hemiplegia and postpartum paralysis, and is one of the components of folk prescriptions, and has a long history of clinical use and definite efficacy. The Guangxi Zhuang folk uses Semiliquidambar cathayesis to make decoction as tea for treating rheumatoid arthritis, and the effect is very good. Semiliquidambar cathayesis of Hamamelidaceae is most commonly used and has the best anti-rheumatic effect. Semiliquidambar cathayesis mainly contains citrulline, cholic acid, resveratrol and 7-ketosteroid, and has significant antibacterial, antioxidant, analgesic and anti-inflammatory effects.
[0018] Catechin is a kind of phenolic active substance extracted from natural plants such as tea leaves, which has the pharmacological effects of antioxidant, anti-inflammatory, antibacterial and the like. The use of catechin alone has the problems of low liposolubility, poor stability and low utilization rate in the human body.
[0019] Giant knotweed is a perennial herb of the genus Polygonum in Polygonaceae, and the leaves, rhizomes and roots of giant knotweed can be used as medicines. Modern pharmacological studies have shown that giant knotweed has the biological activities of immune regulation, anti-inflammatory, antiviral, lipid-lowering, antioxidant and antitumor, and more than 100 prescriptions containing giant knotweed have been successfully applied in clinical treatment. The pharmacological components of giant knotweed are very rich, mainly including stilbenes, anthraquinones, flavonoids, coumarins and the like.
[0020] In summary, due to the adoption of the technical scheme, the present application has the following technical effects: 1.The Yao medicine composition can significantly reduce the swelling degree of mouse auricle inflammation, significantly improve the hot plate pain threshold of mice, and reduce the number of acetic acid-induced mouse pain writhing, which shows that the Yao medicine composition has obvious anti-inflammatory and analgesic effects, and can be used for preparing related drugs.
[0021] 2.The raw material preparation process is simple, the extracts of multiple raw materials are combined, the quality stability of the composition is improved, the treatment effect is significantly improved, the anti-inflammatory effect of multiple components is synergistically enhanced, the stimulation to the body is reduced, the production cost is low, the pain and inflammation are reduced, and the recurrence of various inflammations is reduced. DETAILED DESCRIPTION
[0022] In order to make the purpose, technical scheme and advantages of the present application clearer and more apparent, the following preferred embodiments are given to further illustrate the present application. However, it should be noted that many details in the specification are only to make the reader have a thorough understanding of one or more aspects of the present application, and the aspects of the present application can be realized without these specific details.
[0023] Example 1 A Yao medicine composition for anti-inflammatory and analgesic, which is made of the following raw materials by weight: 30 parts of flemingia, 15 parts of half-fenghe, 1 part of catechin and 12 parts of giant knotweed, and the preparation method comprises the following steps: (1) The above-mentioned raw materials are weighed according to the weight fraction; and flemingia, half-fenghe and giant knotweed are cut into pieces respectively; (2) The flemingia, half-fenghe and giant knotweed are soaked in 8-16 times the amount of water, heated and refluxed at 90-100 DEG C for 30-90 min; (3) The extract is filtered; the filter residue is heated and refluxed with 5 times the amount of water for 20-30 min, and then filtered; the filtrates are combined; (4) The filtrate is concentrated into a concentrated solution with a relative density of 1.05-1.25 g / ml at 90 DEG C under reduced pressure; (5) The concentrated solution is cooled to room temperature, mixed uniformly with catechin, and then concentrated into a concentrated extract with a relative density of 1.2-1.3 g / ml under reduced pressure; (6) The concentrated extract is spray dried, the inlet air temperature of spray drying is 160-165 DEG C, the outlet air temperature is 90-100 DEG C, and the air frequency is 30-40 Hz, to obtain a powder.
[0024] Example 2 A Yao medicine composition for anti-inflammatory and analgesic, which is made of the following raw materials by weight: 40 parts of flemingia, 25 parts of half-fenghe, 4 parts of catechin and 18 parts of giant knotweed, and the preparation method comprises the following steps: (1) The above-mentioned raw materials are weighed according to the weight fraction; and flemingia, half-fenghe and giant knotweed are cut into pieces respectively; (2) The Radix Dipsaci, Radix Paeoniae Alba and Rhizoma Polygoni Cuspidati are soaked in 8-16 times the amount of water, heated to reflux at 90-100°C for 30-90 minutes; (3) The extract is filtered; the residue is extracted with 5 times the amount of water by heating to reflux for 20-30 minutes, and filtered; the filtrates are combined; (4) The filtrate is concentrated under reduced pressure at 90°C to a concentrated solution with a relative density of 1.05-1.25 g / ml; (5) The concentrated solution is cooled to room temperature, mixed with the catechin, and the mixture is concentrated under reduced pressure to a reformed extract with a relative density of 1.2-1.3 g / ml; (6) The extract is spray-dried, with an inlet air temperature of 160-165°C, an outlet air temperature of 90-100°C, and an air frequency of 30-40 Hz, to obtain a powder.
[0025] Example 3 A Yao medicine composition for anti-inflammatory analgesia is made from the following raw materials by weight: Radix Dipsaci 35 parts, Radix Paeoniae Alba 20 parts, catechin 2 parts, and Rhizoma Polygoni Cuspidati 15 parts. The preparation method comprises the following steps: (1) The above raw materials are weighed according to the weight fraction; and the Radix Dipsaci, Radix Paeoniae Alba and Rhizoma Polygoni Cuspidati are separately cut into pieces; (2) The Radix Dipsaci, Radix Paeoniae Alba and Rhizoma Polygoni Cuspidati are soaked in 8-16 times the amount of water, heated to reflux at 90-100°C for 30-90 minutes; (3) The extract is filtered; the residue is extracted with 5 times the amount of water by heating to reflux for 20-30 minutes, and filtered; the filtrates are combined; (4) The filtrate is concentrated under reduced pressure at 90°C to a concentrated solution with a relative density of 1.05-1.25 g / ml; (5) The concentrated solution is cooled to room temperature, mixed with the catechin, and the mixture is concentrated under reduced pressure to a reformed extract with a relative density of 1.2-1.3 g / ml; (6) The extract is spray-dried, with an inlet air temperature of 160-165°C, an outlet air temperature of 90-100°C, and an air frequency of 30-40 Hz, to obtain a powder.
[0026] Example 4 A Yao medicine composition for anti-inflammatory analgesia is made from the following raw materials by weight: Radix Dipsaci 35 parts, Radix Paeoniae Alba 20 parts, catechin 2 parts, and Rhizoma Polygoni Cuspidati 15 parts. The preparation method comprises the following steps: (1) The above raw materials are weighed according to the weight fraction; and the Radix Dipsaci, Radix Paeoniae Alba and Rhizoma Polygoni Cuspidati are separately cut into pieces; (2) The Radix Dipsaci, Radix Paeoniae Alba and Rhizoma Polygoni Cuspidati are soaked in 8-16 times the amount of water, heated to reflux at 90-100°C for 30-90 minutes; (3) filter the extract; the residue is extracted with 5 times the amount of water by heating and refluxing for 20-30 minutes, and filtering; combine the filtrates; (4) further concentrate the filtrate under reduced pressure at 90°C to a concentrated solution with a relative density of 1.05-1.25 g / ml; (5) cool the concentrated solution to room temperature, mix it evenly with catechin, and then concentrate the mixture under reduced pressure to a reformed extract with a relative density of 1.2-1.3 g / ml; (6) spray dry the extract; the inlet air temperature for spray drying is 160-165°C, the outlet air temperature is 90-100°C, and the air frequency is 30-40 Hz, to obtain a powder.
[0027] Example 5 A Yao medicine composition for anti-inflammatory analgesia is made from the following raw materials by weight: 32 parts of Fagara, 18 parts of Semen Macrostyli, 2 parts of catechin, and 14 parts of Giant Knotweed; the preparation method comprises the following steps: (1) weigh the above-mentioned raw materials according to the weight fraction; and shred Fagara, Semen Macrostyli, and Giant Knotweed separately; (2) soak Fagara, Semen Macrostyli, and Giant Knotweed in 8-16 times the amount of water, and extract them by heating and refluxing at 90-100°C for 30-90 minutes; (3) filter the extract; the residue is extracted with 5 times the amount of water by heating and refluxing for 20-30 minutes, and filtering; combine the filtrates; (4) further concentrate the filtrate under reduced pressure at 90°C to a concentrated solution with a relative density of 1.05-1.25 g / ml; (5) cool the concentrated solution to room temperature, mix it evenly with catechin, and then concentrate the mixture under reduced pressure to a reformed extract with a relative density of 1.2-1.3 g / ml; (6) spray dry the extract; the inlet air temperature for spray drying is 160-165°C, the outlet air temperature is 90-100°C, and the air frequency is 30-40 Hz, to obtain a powder.
[0028] Example 6 A Yao medicine composition for anti-inflammatory analgesia is made from the following raw materials by weight: 36 parts of Fagara, 18 parts of Semen Macrostyli, 3 parts of catechin, and 14 parts of Giant Knotweed; the preparation method comprises the following steps: (1) weigh the above-mentioned raw materials according to the weight fraction; and shred Fagara, Semen Macrostyli, and Giant Knotweed separately; (2) soak Fagara, Semen Macrostyli, and Giant Knotweed in 8-16 times the amount of water, and extract them by heating and refluxing at 90-100°C for 30-90 minutes; (3) filter the extract; the residue is extracted with 5 times the amount of water by heating and refluxing for 20-30 minutes, and filtering; combine the filtrates; (4) The filtrate is concentrated under reduced pressure at 90°C to a concentrated solution with a relative density of 1.05-1.25 g / ml; (5) The concentrated solution is cooled to room temperature, mixed uniformly with catechin, and then the mixture is concentrated under reduced pressure to a reformed extract with a relative density of 1.2-1.3 g / ml; (6) The extract is spray-dried, with an inlet temperature of 160-165°C, an outlet temperature of 90-100°C, and a wind frequency of 30-40 Hz, to obtain a powder.
[0029] Comparative Example 1 The preparation method and raw materials are the same as in Example 1, except that no Radix Aristolochiae was added.
[0030] Comparative Example 2 The preparation method and raw materials are the same as in Example 1, except that no Radix Paeoniae Alba was added.
[0031] Comparative Example 3 The preparation method and raw materials are the same as in Example 1, except that no catechin was added.
[0032] Comparative Example 4 The preparation method and raw materials are the same as in Example 1, except that no Polygonum Cuspidatum was added.
[0033] Comparative Example 5 The preparation method and raw materials are the same as in Example 1, except that no Radix Aristolochiae and no Radix Paeoniae Alba were added.
[0034] Comparative Example 6 The preparation method and raw materials are the same as in Example 1, except that no catechin and no Polygonum Cuspidatum were added.
[0035] Test Experiment 1: Anti-inflammatory performance index detection The compositions prepared in Examples 1-6 and Comparative Examples 1-6 were tested for anti-inflammatory performance. 75 SPF male Kunming mice were randomly divided into 15 groups according to body weight: a blank group (normal saline), a model group (1% polysorbate-80 aqueous solution, 10 ml / kg), a positive control group (aspirin suspension, 0.2 g / kg), Examples 1-6, and Comparative Examples 1-6, with 5 mice in each group. The mice in each group of Examples 1-6 and Comparative Examples 1-6 were given a dosage of 10 ml / kg, once a day, for 5 consecutive days.
[0036] 1 h after the last administration, 100% xylene 0.05 mL was evenly applied to the left auricle of each mouse to cause inflammation, and the right ear was used as a control. 0.5 h later, the mice were executed by cervical dislocation, and the mouse ears were cut along the baseline, and a circular ear piece with a diameter of 8 mm was punched out from the same part of the left and right ears using an electric ear swelling punch, and the mass of the ear piece was weighed on an electronic balance. The difference in mass between the two ear pieces was used as the ear swelling degree, and the swelling inhibition rate was calculated. Ear swelling value = left ear piece mass - right ear piece mass, swelling inhibition rate (%) = (model group ear swelling degree - administration group ear swelling degree) / model group ear swelling degree X 100%. The results are shown in Table 1.
[0037] The results in Table 1 show that the ear swelling values of Examples 1-6 are significantly lower than those of Comparative Examples 1-6, and the ear swelling values of Examples 1-6 are close to the positive control group, indicating that the composition of the present application can significantly improve inflammation, and its effect is better than that of other groups, and each raw material has a synergistic effect on inflammation.
[0038] Test Experiment 2 Mouse Foot Swelling Method The compositions prepared in Examples 1-6 and Comparative Examples 1-6 were tested for mouse foot swelling, and 65 SPF male Kunming mice were selected, 5 in each group, and the blank group (normal saline), 1 h after the last administration, each rat left hind foot was inflamed with 10% egg white normal saline solution (freshly prepared before use) 0.1 mL, and the foot volume before and 1 h after inflammation was determined by volume method, and the foot swelling degree was calculated. The results are shown in Table 2.
[0039] Foot swelling degree = foot volume 1 h after the last administration - foot volume before administration.
[0040] The results in Table 2 show that the foot swelling degree of the blank mice is significantly higher, the foot swelling degree of the mice in the administration treatment group, Examples 1-6, is significantly decreased, and the decrease is more obvious than that of Comparative Examples 1-6.
[0041] Test Experiment 3 Acetic Acid Writhing Method The compositions prepared in the above Examples 1-6 and Comparative Examples 1-6 were subjected to mouse trauma writhing test. 65 SPF male Kunming mice were selected, 5 mice in each group, blank group (normal saline), the mice were anesthetized, after anesthesia, a 5mm diameter epidermis wound was made on the back of the mice, and the wound was given a dose of 0.5mg / ml, a dose of 30ul, and 0.5h after treatment, 0.6% acetic acid, 0.2mL per mouse (the acetic acid solution was prepared before use) was added to each mouse. The number of writhing reactions (abdominal contraction, body and hind limb stretching) of each group of mice within 15min after adding acetic acid was recorded, and the analgesic inhibition rate was calculated. Analgesic inhibition rate (%) = (number of writhing reactions of blank group-number of writhing reactions of administration group) / number of writhing reactions of blank group x 100%. The results are shown in Table 3.
[0042] The results in Table 3 show that the Yao medicine composition prepared in Examples 1-6 of the present application can significantly reduce the number of mouse writhing, has a good analgesic effect on mice, and each raw material can significantly improve the analgesic effect, and the combination effect is obviously higher than that of other combinations.
[0043] The above description is only the preferred embodiments of the present application, and it should be pointed out that for ordinary skilled in the art, without departing from the principles of the present application, a number of improvements and refinements can be made, and these improvements and refinements should be considered as the protection scope of the present application.
Claims
1. A Yao medicine composition for anti-inflammatory analgesia, characterized in that, The Yao medicine composition is prepared from the following raw materials by weight: Ficus tikoua 30-40 parts, Ficus tikoua var. hypogallica 15-25 parts, catechin 1-4 parts, and giant knotweed 12-18 parts.
2. The Yao medicine composition for anti-inflammatory analgesia according to claim 1, characterized in that, The Yao medicine composition is prepared from the following raw materials by weight: Ficus tikoua 30-40 parts, Ficus tikoua var. hypogallica 15-25 parts, catechin 1-4 parts, and giant knotweed 12-18 parts.
3. The Yao medicine composition for anti-inflammatory analgesia according to claim 1, characterized in that, The Yao medicine composition is prepared from the following raw materials by weight: Ficus tikoua 30-40 parts, Ficus tikoua var. hypogallica 15-25 parts, catechin 1-4 parts, and giant knotweed 12-18 parts.
4. The use of the Yao medicine composition for anti-inflammatory analgesic according to claim 1, characterized in that, The application includes a preparation of the Yao medicine composition alone or in combination with other drugs.
5. The use of the Yao medicine composition for anti-inflammatory analgesic according to claim 4, characterized in that, The preparation includes any dosage form in pharmacy.
6. A method for preparing the Yao medicine composition for anti-inflammatory analgesic as claimed in claim 1, characterized in that, The method comprises the following steps: (1) The raw materials are weighed according to the weight ratio, and Ficus tikoua, Ficus tikoua var. hypogallica, and giant knotweed are cut into pieces; (2) Ficus tikoua, Ficus tikoua var. hypogallica, and giant knotweed are soaked in 8-16 times the amount of water, heated, and refluxed for a period of time; (3) The extract is filtered, the residue is heated and refluxed with 5 times the amount of water for 20-30 min, and the filtrate is combined; (4) The filtrate is concentrated under reduced pressure at 90 ℃ to form a concentrated solution with a relative density of 1.05-1.25 g / ml; (5) The concentrated solution is cooled to room temperature, mixed with catechin, and then concentrated under reduced pressure to form an extract with a relative density of 1.2-1.3 g / ml; (6) The extract is spray-dried to obtain a powder.
7. The method for preparing the Yao medicine composition for anti-inflammatory analgesia according to claim 6, characterized in that, In step (2), the heating and refluxing is performed at 90-100 ℃ for 30-90 min.
8. The method for preparing the Yao medicine composition for anti-inflammatory analgesia according to claim 6, characterized in that, In step (3), the heating and refluxing is performed for 25-30 min.
9. The method for preparing the Yao medicine composition for anti-inflammatory analgesia according to claim 6, characterized in that, In step (6), the spray-drying is performed at an inlet temperature of 160-165 ℃, an outlet temperature of 90-100 ℃, and a wind frequency of 30-40 Hz.
10. A medicament having anti-inflammatory and / or analgesic properties, characterized in that it comprises a compound of the formula (I) as defined in claim 1. The Yao medicine composition for anti-inflammatory and analgesic purposes as claimed in any one of claims 1-5.