Capsule for promoting gastrointestinal mucosa repair and preparation method thereof

Abstract

The invention relates to the technical field of biological medicines, and particularly discloses a capsule for promoting gastrointestinal mucosa repair and a preparation method thereof. The capsule for promoting gastrointestinal mucosa repair comprises a capsule core and a capsule skin, the capsule core is prepared from the following components in parts by weight according to the weight of the capsule core: 40 to 60 parts of radix astragali seu hedysari extract, 20 to 30 parts of hericium erinaceus extract, 10 to 20 parts of radix notoginseng extract, 5 to 10 parts of glutamine derivative and 3 to 5 parts of growth factor; the growth factor is a mixture of an insulin-like growth factor and a glial cell-derived neurotrophic factor in a weight ratio of 1: (0.2-0.5); the invention also provides a preparation method of the capsule. The capsule for promoting gastrointestinal mucosa repair provided by the invention can be dissolved and release active ingredients in a specific pH environment of the gastrointestinal tract, so that the gastrointestinal tract is protected, and cell proliferation and gastrointestinal mucosa repair are promoted.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biological medicine, in particular to a capsule for promoting gastrointestinal mucosa repair and a preparation method thereof. BACKGROUND

[0002] In the field of medicine and health, gastrointestinal diseases have been one of the important problems that have plagued people's health. With the acceleration of life pace, the change of eating habits and the influence of environmental factors, the damage to the gastrointestinal mucosa is increasingly common. The health of the gastrointestinal mucosa is crucial for the normal functioning of the entire digestive system, as it not only protects the gastrointestinal tract from harmful substances, but also participates in the digestion and absorption of nutrients. Therefore, the research on promoting the repair of gastrointestinal mucosa has always been a hot direction in the field of medicine and pharmacy, which is of great significance for improving the quality of life and preventing and treating gastrointestinal diseases.

[0003] At present, the methods for promoting the repair of gastrointestinal mucosa in the prior art mainly include the following: first, traditional Western medicine treatment, such as using proton pump inhibitors to inhibit gastric acid secretion, reducing the stimulation of gastric acid to the damaged mucosa, thereby creating a relatively mild environment for mucosa repair; and using gastric mucosa protectants to form a protective film on the mucosa surface to prevent further erosion of harmful substances. Second, using some single plant extracts for conditioning, such as some herbal extracts with anti-inflammatory and antioxidant effects, which promote mucosa repair by regulating the body's physiological functions. In addition, dietary therapy is also one of the commonly used means, which reduces the burden on the gastrointestinal tract by eating food rich in nutrients and easy to digest, and promotes the recovery of self-repairing ability.

[0004] However, these existing methods for promoting the repair of gastrointestinal mucosa have certain limitations. For example, traditional Western medicine treatment often focuses on relieving symptoms, and has only an indirect effect on mucosa repair, which cannot fundamentally and quickly and effectively promote mucosa regeneration and repair. The efficacy of single plant extracts is relatively limited, which is difficult to meet the complex needs of gastrointestinal mucosa repair. Although dietary therapy is safe, the effect is relatively slow and cannot respond to severe mucosa damage in a timely manner. In addition, the above-mentioned methods also have the problem that the active ingredients cannot be precisely released at specific sites in the gastrointestinal tract, making it difficult to fully exert their therapeutic effects, and thus the repair effect of the gastrointestinal mucosa is limited.

[0005] Therefore, it is of great significance to develop a drug with controllable drug release and good gastrointestinal mucosa repair effect for the treatment of gastrointestinal diseases. SUMMARY

[0006] In order to overcome the defect of limited repair effect in the existing methods for repairing gastrointestinal mucosa, the present application provides a capsule for promoting gastrointestinal mucosa repair and a preparation method thereof.

[0007] In a first aspect, the application provides a capsule for promoting repair of gastrointestinal mucosa, which adopts the following technical solution: A capsule for promoting repair of gastrointestinal mucosa, comprising a capsule core and a capsule shell; The capsule core comprises the following components in parts by weight: 40-60 parts of Astragalus extract, 20-30 parts of Hericium extract, 10-20 parts of Panax notoginseng extract, 220-250 parts of sesame oil, 10-20 parts of beeswax, 5-10 parts of glutamine derivative, and 3-5 parts of growth factor, based on the weight of the capsule core. The growth factor is a mixture of insulin-like growth factor and glial cell-derived neurotrophic factor at a weight ratio of 1: (0.2-0.5).

[0008] The capsule for promoting repair of gastrointestinal mucosa provided by the application can dissolve in a specific pH environment in the gastrointestinal tract after being taken, and release the active ingredients in the capsule core, which can directly act on the damaged mucosa site, protect the gastrointestinal tract, and promote cell proliferation and repair of the gastrointestinal mucosa. Specifically, the Astragalus extract in the capsule core provided by the application contains various active ingredients, which can enhance the body's immunity, improve the internal environment of the gastrointestinal tract, and provide good basic conditions for mucosal repair. In addition, it can also regulate the physiological function of the gastrointestinal tract and promote the normal peristalsis of the gastrointestinal tract, so that food is better digested and absorbed in the gastrointestinal tract. The Hericium extract is rich in nutrients such as polysaccharides and polypeptides, and has the effect of protecting the gastric mucosa, which can reduce the stimulation and damage of gastric acid, pepsin, etc. to the gastric mucosa, and at the same time provide nutritional support for the damaged mucosa, and accelerate the repair process. Panax notoginseng extract has the effect of promoting blood circulation to remove blood stasis, which can improve the blood circulation of the gastrointestinal mucosa, transport sufficient oxygen and nutrients to the mucosal cells, and help promote the regeneration and repair of mucosal cells, and has a good therapeutic effect on mucosal damage caused by ischemia and hypoxia. Glutamine derivative can provide energy for gastrointestinal mucosal cells, maintain normal metabolism and function of mucosal cells, enhance the barrier function of mucosa, and resist the invasion of external pathogens. Growth factor can stimulate cell proliferation and differentiation, promote ulcer healing, enhance mucosal barrier function, and thus restore the integrity and function of mucosal tissue. In summary, the capsule for promoting repair of gastrointestinal mucosa provided by the application can comprehensively promote the repair of gastrointestinal mucosa and improve the health status of the gastrointestinal tract through the synergistic effect of the components in the capsule core.

[0009] In the present application, insulin-like growth factor can promote the proliferation and differentiation of gastrointestinal mucosal cells on the one hand, accelerate the generation of new cells, and promote the repair of damaged mucosa; on the other hand, it can also inhibit the secretion of gastric acid, reduce the stimulation of gastric acid to damaged mucosa, and provide a healthy environment for mucosal repair. Glial cell-derived neurotrophic factor can inhibit the apoptosis of gastrointestinal glial cells and epithelial cells through autocrine and paracrine, maintain the integrity of the intestinal barrier; on the other hand, it can reduce the release of pro-inflammatory factors such as INF-α and IL-6, thereby relieving the inflammatory microenvironment of the mucosa and avoiding excessive inflammatory response to interfere with the repair process; in addition, during the repair of gastrointestinal mucosa, glial cell-derived neurotrophic factor can also participate in promoting mucosal reconstruction and angiogenesis, supporting the proliferation and differentiation of stem cells and the activity of fibroblasts, and providing necessary nutrients and oxygen for the repair process. The present application found through experiments that the capsule for promoting the repair of gastrointestinal mucosa prepared by using insulin-like growth factor and glial cell-derived neurotrophic factor in combination, and controlling the weight ratio of the two within the above range, has a faster repair speed for intestinal mucosa.

[0010] Optionally, the capsule core comprises the following components by weight: 40-60 parts of Astragalus extract, 20-30 parts of Hericium extract, 10-20 parts of Panax notoginseng extract, 220-250 parts of sesame oil, 10-20 parts of beeswax, 8-10 parts of glutamine derivative, and 3-4 parts of growth factor.

[0011] In some embodiments, the glutamine derivative is 5-8 parts or 8-10 parts.

[0012] In a specific embodiment, the weight of the glutamine derivative can be 5 parts, 8 parts or 10 parts.

[0013] In some embodiments, the glutamine derivative is 3-4 parts or 4-5 parts.

[0014] In a specific embodiment, the weight of the glutamine derivative can be 3 parts, 4 parts or 5 parts.

[0015] Optionally, the weight ratio of the insulin-like growth factor and the glial cell-derived neurotrophic factor is 1: (0.3-0.4).

[0016] In some embodiments, the weight ratio of the insulin-like growth factor and the glial cell-derived neurotrophic factor can be 1: (0.2-0.3), 1: (0.2-0.35), 1: (0.2-0.4), 1: (0.3-0.35), 1: (0.3-0.4), 1: (0.3-0.5), 1: (0.3-0.4), 1: (0.35-0.5), or 1: (0.4-0.5).

[0017] In a specific embodiment, the weight ratio of the insulin-like growth factor and the glial cell-derived neurotrophic factor can also be 1:0.2, 1:0.3, 1:0.35, 1:0.4, or 1:0.5.

[0018] Optionally, the glutamine derivative is selected from one or more of acetylglutamine, glycolglutamine, propylglutamine, pyrrolidone carboxylic acid, and gamma-glutamyl cysteine.

[0019] Optionally, the glutamine derivative is a mixture of pyrrolidone carboxylic acid and gamma-glutamyl cysteine.

[0020] Optionally, the weight ratio of the pyrrolidone carboxylic acid and the gamma-glutamyl cysteine is 1:(1.5-3).

[0021] In some embodiments, the weight ratio of the pyrrolidone carboxylic acid and the gamma-glutamyl cysteine is 1:(1.5-2), 1:(1.5-2.5), 1:(2-2.5), 1:(2-3), or 1:(2.5-3).

[0022] In a specific embodiment, the weight ratio of the pyrrolidone carboxylic acid and the gamma-glutamyl cysteine is 1:1.5, 1:2, 1:2.5, or 1:3.

[0023] Optionally, the capsule shell comprises the following components by weight: gelatin 180-220 parts, hydroxypropyl methyl cellulose 50-100 parts, glycerol 100-150 parts, and water 280-320 parts, based on the weight of the capsule shell.

[0024] The present application can ensure the integrity and stability of the capsule by using gelatin, hydroxypropyl methyl cellulose, glycerol, and water to prepare the capsule shell, so that the capsule core ingredients can be slowly released at the damaged site of the gastrointestinal mucosa, thereby exerting its best repair effect. Specifically, gelatin as the main film-forming material of the capsule shell can form a tough and elastic film structure, effectively wrapping the capsule core to prevent content leakage, while also ensuring the stability of the capsule during storage and transportation. Hydroxypropyl methyl cellulose can improve the flexibility and transparency of the capsule shell, making the capsule appearance more beautiful, and can also adjust the dissolution rate of the capsule shell to allow the drug to be released more accurately in the gastrointestinal tract. Glycerol as a plasticizer can increase the softness and plasticity of the capsule shell, avoid capsule shell rupture due to drying, and prolong the shelf life of the capsule. In summary, the above-mentioned specific formulation of the capsule shell can better adapt to the gastrointestinal environment, ensuring the accurate release of the active ingredients in the capsule that promote the repair of the gastrointestinal mucosa at specific sites in the gastrointestinal tract, fully exerting its therapeutic effect, and achieving efficient repair of the gastrointestinal mucosa.

[0025] In a second aspect, the application provides a preparation method of a capsule for promoting gastrointestinal mucosa repair, comprising the following steps: preparation of a capsule core material, preparation of a capsule shell material, and preparation of the capsule. Preparation of the capsule core material: place sesame oil and beeswax in a preparation tank, heat to 70-80℃, and stir at a speed of 700-850 rpm for 5-10 min, and then cool to room temperature; then add Astragalus extract, Hericium extract, Panax notoginseng extract, glutamine derivative, and growth factor under stirring, stir for 30-40 min, grind 3 times through a colloid mill, and vacuum degassing to obtain the capsule core material. Preparation of the capsule shell material: place water and glycerol in a gel preparation tank, heat to 55-65℃; then add gelatin and hydroxypropyl methylcellulose, heat to 70-80℃ while stirring at a speed of 1000-1100 rpm; after the gelatin is completely swelled and no particles are left, vacuum degassing, and sieve the gel through an 80-mesh sieve to obtain the capsule shell material.

[0026] Optionally, the specific steps for preparing the capsule are as follows: the capsule core material and the capsule shell material are respectively put into a soft capsule machine at a weight ratio of 1:(1.4-1.6), and then pressure balling, shaping, washing, drying, and screening are performed to obtain the capsule for promoting gastrointestinal mucosa repair.

[0027] Optionally, the capsule for promoting gastrointestinal mucosa repair has a specification of 0.5 g / pill.

[0028] In summary, the application has the following beneficial effects: 1. The application provides a capsule for promoting gastrointestinal mucosa repair, which comprises a capsule shell and a capsule core, and the capsule core contains various plant extracts, glutamine derivative, and growth factor as active ingredients. After taking the capsule, the capsule shell can dissolve in a specific pH environment in the gastrointestinal tract, and release the active ingredients in the capsule core, thereby protecting the gastrointestinal tract, promoting cell proliferation, and repairing the gastrointestinal mucosa.

[0029] 2. The weight ratio of insulin-like growth factor and glial cell-derived neurotrophic factor is controlled in the range of 1:(0.3-0.4), and pyrrolidone carboxylic acid and γ-glutamyl cysteine with a weight ratio of 1:(1.5-3) are used as the glutamine derivative in the capsule core, so that the obtained capsule has better protective effect on the gastrointestinal mucosa damaged by anhydrous ethanol. DETAILED DESCRIPTION

[0030] The application provides a capsule for promoting gastrointestinal mucosa repair, which comprises a capsule core and a capsule shell. The capsule core comprises the following components by weight parts: Astragalus extract 40-60 parts, Hericium extract 20-30 parts, Panax notoginseng extract 10-20 parts, sesame oil 220-250 parts, beeswax 10-20 parts, glutamine derivative 5-10 parts, and growth factor 3-5 parts, based on the weight of the capsule core; The capsule shell comprises the following components by weight parts: gelatin 180-220 parts, hypromellose 50-100 parts, glycerol 100-150 parts, and water 280-320 parts, based on the weight of the capsule shell.

[0031] The growth factor is a mixture of insulin-like growth factor and glial cell-derived neurotrophic factor at a weight ratio of 1:(0.2-0.5); the glutamine derivative is selected from one or more of acetyl glutamine, glycolyl glutamine, propionyl glutamine, pyrrolidone carboxylic acid, and γ-glutamyl cysteine. Further, the weight ratio of the insulin-like growth factor and the glial cell-derived neurotrophic factor is 1:(0.3-0.4). The glutamine derivative is a mixture of pyrrolidone carboxylic acid and γ-glutamyl cysteine. Still further, the weight ratio of the pyrrolidone carboxylic acid and the γ-glutamyl cysteine is 1:(1.5-3).

[0032] The application provides a preparation method of the capsule for promoting gastrointestinal mucosa repair, comprising the following steps: (1) Preparation of capsule core material: place sesame oil and beeswax in a blending tank, heat to 70-80℃, and stir at a speed of 700-850 rpm for 5-10 min, and then cool to room temperature; then add Astragalus extract, Hericium extract, Panax notoginseng extract, glutamine derivative, and growth factor under stirring, stir for 30-40 min, grind 3 times through a colloid mill, and vacuum degassing to obtain the capsule core material; (2) Preparation of capsule shell material: place water and glycerol in a gelatinizing tank, heat to 55-65℃; then add gelatin and hypromellose, and heat to 70-80℃ while stirring at a speed of 1000-1100 rpm; after the gelatin is completely swelled without particles, vacuum degassing, and 80-mesh sieving, the capsule shell material is obtained; (3) Preparation of capsule: the capsule core material and the capsule shell material are respectively put into a soft capsule machine at a weight ratio of 1:(1.4-1.6), and then pressure pill, shape, wash pill, dry, and sieve to obtain the capsule for promoting gastrointestinal mucosa repair.

[0033] In the embodiments of the present application, the CAS number of the Astragalus extract is 83207-58-3, which is purchased from Hubei Chengfeng Chemical Co., Ltd.; the Hericium extract is food grade, 95%, purchased from Baoji Kosme Plant Polysaccharide Development Co., Ltd.; the CAS number of the Panax notoginseng extract is 80418-29-7, which is purchased from Shaanxi Chenming Biological Technology Co., Ltd.; the CAS number of the sesame oil is 8008-74-0; the CAS number of the beeswax is 8012-89-3; the insulin-like growth factor is purchased from Sichuan Weikeqi Biological Technology Co., Ltd., with the product number WKQ-0035690; the glial cell-derived neurotrophic factor is purchased from Yakeyin Biological Technology Co., Ltd., with the product number PRP1067; the CAS number of the pyrrolidone carboxylic acid is 149-87-1; and the CAS number of the γ-glutamyl cysteine is 636-58-8. The raw materials, reagents, solvents and the like used in the present application can be commercially available.

[0034] The present application will be further described in detail in combination with the examples and performance detection tests. Examples 1-5

[0035] Examples 1-5 respectively provide a capsule for promoting repair of gastrointestinal mucosa.

[0036] The differences between the above examples are the addition amounts of glutamine derivatives and growth factors, which are specifically shown in Table 1.

[0037] The preparation method of the capsule for promoting repair of gastrointestinal mucosa provided in Examples 1-5 comprises the following steps: (1) Preparation of the core material: 250 g of sesame oil and 15 g of beeswax were placed in a blending tank and heated to 75°C, and then stirred at a speed of 800 rpm for 5 min, and then cooled to room temperature; then 50 g of Astragalus extract, 25 g of Hericium extract, 15 g of Panax notoginseng extract, glutamine derivatives (acetyl glutamine) and growth factors (insulin-like growth factor and glial cell-derived neurotrophic factor with a weight ratio of 1:0.35) were added under stirring, and stirred for 30 min, and then ground for 3 times by a colloid mill, and then vacuum degassed to obtain the core material; (2) Preparation of the shell material: 300 g of water and 140 g of glycerol were placed in a gelatin tank and heated to 60°C; then 200 g of gelatin and 80 g of hydroxypropyl methyl cellulose were added, and heated to 75°C while stirring at a speed of 1000 rpm; after the gelatin was completely swelled without particles, vacuum degassing and 80 mesh sieving were performed to obtain the shell material; (3) Preparation of the capsule: the core material and the shell material were respectively put into a soft capsule machine according to a weight ratio of 1:1.5 for pill pressing, and then shaped, washed, dried and sieved to obtain the capsule for promoting repair of gastrointestinal mucosa with a specification of 0.5 g / pill.

[0038] Table 1 Amount of glutamine derivative and growth factor added in capsules provided in Examples 1-5 Examples 6-9

[0039] Examples 6-9 each provide a capsule for promoting repair of gastrointestinal mucosa.

[0040] The above examples differ from Example 2 in the weight ratio of the two growth factors, as shown in Table 2 below.

[0041] Table 2 Weight ratio of two growth factors in Examples 2, 6-9 Examples 10-17

[0042] Examples 10-17 each provide a capsule for promoting repair of gastrointestinal mucosa.

[0043] The above examples differ from Example 2 in the type and ratio of glutamine derivative, as shown in Table 3 below.

[0044] Table 3 Type and ratio of glutamine derivative in Examples 2, 10-17 Comparative Example 1

[0045] Comparative Example 1 provides a capsule for promoting repair of gastrointestinal mucosa.

[0046] The above comparative example differs from Example 2 in that the amount of glutamine derivative added is 0. Comparative Example 2

[0047] Comparative Example 2 provides a capsule for promoting repair of gastrointestinal mucosa.

[0048] The above comparative example differs from Example 2 in that the amount of growth factor added is 0. Comparative Example 3

[0049] Comparative Example 3 provides a capsule for promoting repair of gastrointestinal mucosa.

[0050] The above comparative example differs from Example 2 in that the growth factor is insulin-like growth factor. Comparative Example 4

[0051] Comparative Example 4 provides a capsule for promoting repair of gastrointestinal mucosa.

[0052] The above comparative example differs from Example 2 in that the growth factor is glial cell-derived neurotrophic factor. Comparative Example 5

[0053] Comparative Example 5 provides a capsule for promoting repair of gastrointestinal mucosa.

[0054] The above comparative example differs from Example 2 in that the growth factors are insulin-like growth factor and epidermal growth factor in a weight ratio of 1:0.35. Performance detection test

[0055] Capsules for promoting repair of gastrointestinal mucosa obtained from Examples 1-17 and Comparative Examples 1-5 were subjected to animal experiments, and the specific process was as follows: (1) 230 healthy male SD rats, 180-220 g each, were selected and randomly divided into 23 groups, 10 rats each. Seventeen groups (test groups 1-17) of rats were administered with the capsule core material provided by Examples 1-17, the administration amount was 50 mg / 100 g, five groups (control groups 1-5) of rats were administered with the capsule core material provided by Comparative Examples 1-5, the administration amount was 50 mg / 100 g, and one group of rats was administered with normal saline every day; continuous administration for 30 days; (2) After 30 days, all animals were fasted for 48 hours, and water was not limited. All animals were orally administered with absolute ethanol, the administration amount was 1 ml per animal. One hour later, the animals were sacrificed, the stomach was dissected, perfused with an appropriate amount of 10% formaldehyde solution, and fixed for 20 min. Then, the stomach was cut along the greater curvature, the degree of gastric mucosal injury was observed, the length of gastric mucosal injury was measured with a precision caliper (unit: mm), the sum of the length of gastric mucosal injury was taken as the ulcer index, and the average value of each group was taken as the result, which was shown in Table 4.

[0056] Table 4 Influence of capsules obtained from Examples 1-17 and Comparative Examples 1-5 on ulcer index of ethanol-damaged rats

[0057] According to the detection results in Table 4, the ulcer index of the rats in test groups 1-17 was 18.7-32.2 mm; and the ulcer index of the rats in the blank control group was 73.4 mm. It was indicated that the capsules for promoting repair of gastrointestinal mucosa provided by Examples 1-17 had a good protective effect on the gastrointestinal mucosa damaged by absolute ethanol.

[0058] According to the detection results of test groups 1-5 and control groups 1-2, the ulcer index of the rats in test groups 1-5 was 27.4-32.2 mm after being administered with the capsules containing glutamine derivatives and growth factors provided by Examples 1-5; and the ulcer index of the rats in control groups 1-2 was 43.8-47.6 mm after being administered with the capsules containing only glutamine derivatives or growth factors provided by Comparative Examples 1-2. Therefore, it was indicated that the capsules prepared by using various plant extracts, glutamine derivatives and growth factors as the core material had a good protective and repair effect on the gastrointestinal mucosa.

[0059] The results of the detection of the test group 2, the test group 6-9 and the control group 3-5 show that the rats of the test group 2 and the test group 6-9 use the capsules in which the insulin-like growth factor and the glial cell-derived neurotrophic factor are used as the growth factors in the capsule core, and the ulcer index of the rats is 27.4-31.4 mm; while the rats of the control group 3-5 use the capsules in which only the insulin-like growth factor or the glial cell-derived neurotrophic factor is used as the growth factor in the capsule core, or the insulin-like growth factor and the epidermal growth factor with a weight ratio of 1:0.35 are used as the growth factors in the capsule core, and the ulcer index of the rats is 36.9-42.2 mm; further comparison shows that the ulcer index of the rats of the test group 2, the test group 7-8 is 27.4-29.3 mm (≤30.0 mm). Therefore, it is indicated that the weight ratio of the insulin-like growth factor and the glial cell-derived neurotrophic factor is controlled in the range of 1:(0.3-0.4) in the present application, and the obtained capsules have better protection effect on the damaged gastrointestinal mucosa caused by anhydrous ethanol.

[0060] The results of the detection of the test group 2, the test group 10-17 show that the rats of the test group 1, the test group 10-11 use the capsules in which the acetyl glutamine, pyrrolidone carboxylic acid or γ-glutamyl cysteine is used as the glutamine derivative in the capsule core, and the ulcer index of the rats is 27.4-31.8 mm; the rats of the test group 12-13 use the capsules in which the acetyl glutamine and γ-glutamyl cysteine with a weight ratio of 1:2 or the pyrrolidone carboxylic acid and acetyl glutamine with a weight ratio of 1:2 are used as the glutamine derivative in the capsule core, and the ulcer index of the rats is 25.2-26.7 mm; while the rats of the test group 14-17 use the capsules in which the pyrrolidone carboxylic acid and γ-glutamyl cysteine with a weight ratio of 1:(1.5-3) are used as the glutamine derivative in the capsule core, and the ulcer index of the rats is 18.7-23.3 mm (≤24 mm). It is indicated that the pyrrolidone carboxylic acid and γ-glutamyl cysteine with a weight ratio of 1:(1.5-3) are further used as the glutamine derivative in the capsule core in the present application, and the obtained capsules have more significant protection effect on the damaged gastrointestinal mucosa caused by anhydrous ethanol.

[0061] Although the present application has been described in detail by the general description and the specific embodiments above, some modifications or improvements can be made on the basis of the present application, which is obvious to those skilled in the art. Therefore, these modifications or improvements made on the basis of not deviating from the spirit of the present application, all belong to the scope of protection claimed by the present application.

Claims

1. A capsule for promoting repair of the gastrointestinal mucosa, characterized in that, The capsule core and the capsule shell are included; The capsule core comprises the following components by weight parts: 40-60 parts of Astragalus extract, 20-30 parts of Hericium extract, 10-20 parts of Panax notoginseng extract, 220-250 parts of sesame oil, 10-20 parts of beeswax, 5-10 parts of glutamine derivative, and 3-5 parts of growth factor; The growth factor is a mixture of insulin-like growth factor and glial cell-derived neurotrophic factor at a weight ratio of 1: (0.2-0.5).

2. The capsule to promote gastrointestinal mucosa repair according to claim 1, characterized by, The capsule core comprises the following components by weight parts: 40-60 parts of Astragalus extract, 20-30 parts of Hericium extract, 10-20 parts of Panax notoginseng extract, 220-250 parts of sesame oil, 10-20 parts of beeswax, 8-10 parts of glutamine derivative, and 3-4 parts of growth factor.

3. The capsule to promote gastrointestinal mucosa repair according to claim 1, characterized by the fact that, The weight ratio of the insulin-like growth factor and the glial cell-derived neurotrophic factor is 1: (0.3-0.4).

4. The capsule for promoting repair of the gastrointestinal mucosa according to claim 3, characterized in that, The glutamine derivative is selected from one or more of acetyl glutamine, glycolyl glutamine, propionyl glutamine, pyrrolidone carboxylic acid, and γ-glutamyl cysteine.

5. The capsule to promote repair of the gastrointestinal mucosa according to claim 4, characterized in that, The glutamine derivative is a mixture of pyrrolidone carboxylic acid and γ-glutamyl cysteine.

6. The capsule to promote repair of the gastrointestinal mucosa according to claim 5, characterized in that, The weight ratio of the pyrrolidone carboxylic acid and the γ-glutamyl cysteine is 1: (1.5-3).

7. The capsule to promote gastrointestinal mucosa repair according to claim 1, characterized by the fact that it comprises, The capsule shell comprises the following components by weight parts based on the weight of the capsule shell: 180-220 parts of gelatin, 50-100 parts of hydroxypropyl methyl cellulose, 100-150 parts of glycerol, and 280-320 parts of water.

8. The method of preparing a capsule for promoting repair of the gastrointestinal mucosa according to any one of claims 1 to 7, wherein The method comprises the following steps: Preparation of capsule core material, preparation of capsule shell material, and preparation of capsules; Preparation of capsule core material: the sesame oil and beeswax are placed in a blending tank and heated to 70-80°C, and stirred at a speed of 700-850 rpm for 5-10 min, and then cooled to room temperature; then the Astragalus extract, Hericium extract, Panax notoginseng extract, glutamine derivative, and growth factor are added while stirring, and stirred for 30-40 min, and ground 3 times through a colloid mill, and vacuum degassed to obtain the capsule core material; Preparation of capsule shell material: the water and glycerol are placed in a gelatinizing tank and heated to 55-65°C; then the gelatin and hydroxypropyl methyl cellulose are added, and heated to 70-80°C while stirring at a speed of 1000-1100 rpm; after the gelatin is completely swelled and no particles are present, vacuum degassing and 80-mesh sieving of the gelatin are performed to obtain the capsule shell material.

9. The method of claim 8, wherein the capsule is prepared by mixing the active ingredient and the pharmaceutically acceptable carrier, and then filling the mixture into a capsule shell. The specific steps for preparing the capsules are as follows: the capsule core material and the capsule shell material are respectively placed in a soft capsule machine at a weight ratio of 1: (1.4-1.6), and then pressed, shaped, washed, dried, and sieved to obtain the capsules for promoting repair of gastrointestinal mucosa.

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