Stability-enhanced microencapsulation treatment system and method for active ingredients of eucommia seeds
By setting up an energy storage tank and heat exchange components inside the mixing tank, the problem of low temperature control efficiency was solved, achieving rapid temperature regulation and uniformity, and improving the microencapsulation efficiency of Eucommia ulmoides seed active ingredients.
Patent Information
- Application Number
- CN202511140043.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-14
- Publication Date
- 2025-11-07
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
In existing technologies, the temperature control efficiency of mixed emulsions is low, which leads to an increase in mixing time and affects the production efficiency of microencapsulation of active ingredients in Eucommia ulmoides seeds.
An energy storage tank with a heat source and a cold source on the back of the mixing tank is used. Combined with heat exchange components and communication components, the temperature inside the mixing tank can be quickly regulated. The heat exchange area of the emulsion is increased by spiral baffles to ensure temperature uniformity.
It enables rapid temperature control within the mixing tank, reduces mixing time, and improves the efficiency of microencapsulation and the stability of the active ingredients in Eucommia ulmoides seeds.
Smart Images
Figure CN120900529A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of microencapsulation of active ingredients of eucommia seed, and particularly relates to a microencapsulation system and method for enhancing the stability of active ingredients of eucommia seed. BACKGROUND
[0002] Eucommia seed oil (EUSO) is a natural plant oil rich in various nutrients and is widely used due to its unique medicinal effects. However, it is prone to oxidation and rancidity under many adverse environmental influences. Nanocapsulation technology can protect and slow down the loss of its biological activity; currently, there are several methods that can be used to synthesize nanoparticles for biomedical applications, including complex coacervation, ionotropic gelation, desolvation, and self-assembly. Among them, ionotropic gelation is to induce ion gelation of polymers such as chitosan under appropriate conditions with non-toxic tripolyphosphate (TPP). Due to its simple operation, mild reaction conditions, high encapsulation efficiency, strong controllability, and high stability, it has been widely used in the preparation of nanoparticles in recent years.
[0003] In the prior art, the nanometer particles are usually prepared by combining emulsification and ion gelation in two steps, which means that the water phase and the oil phase need to be mixed uniformly before the ion gelation reaction to form a water-in-oil lotion. During the mixing process, the required environmental temperature is different for each step, and the temperature regulation efficiency of the existing microcapsule processing system is low, which prolongs the mixing time and affects the production efficiency. SUMMARY
[0004] The purpose of the present application is to solve the problem of inconvenient and rapid temperature regulation in the prior art, and to provide a microencapsulation system and method for enhancing the stability of active ingredients of eucommia seed.
[0005] In order to achieve the above-mentioned purpose, the technical scheme adopted by the present application is as follows: A microencapsulation system for enhancing the stability of active ingredients of eucommia seed, comprising a mixing tank for mixing emulsion, two groups of energy storage tanks for providing heat source and cold source respectively are arranged on the back of the mixing tank, the energy storage tanks are communicated with the top of the mixing tank through a communication assembly, and a heat exchange assembly for keeping the temperature of the mixing tank uniform is fixed on the surface of the mixing tank. The energy storage tank comprises a tank body and a perforated plate fixed in the tank body, and a plurality of energy storage balls are stacked above the perforated plate.
[0006] In some embodiments, the communication assembly comprises a first communication pipe fixed on the top of the mixing tank and an air pump fixed on the lower end of the first communication pipe, the air inlet of the air pump is communicated with the top of the tank body through a three-way reversing valve, and the other end of the three-way reversing valve is used to extract normal temperature air.
[0007] In some embodiments, the heat exchange assembly comprises a heat preservation cover fixed on the surface of the mixing tank and a spiral partition fixed on the inner wall of the heat preservation cover, the heat preservation cover wraps the mixing tank, and the spiral partition divides a spiral channel between the heat preservation cover and the mixing tank.
[0008] In some embodiments, the surface of the mixing tank is provided with a reflux assembly for circulating the heat source or the cold source, the reflux assembly comprises two second communication pipes for communicating the heat preservation cover with two first communication pipes, and the reflux assembly further comprises two first reflux pipes for refluxing the heat source and the cold source into two energy storage tanks, respectively.
[0009] In some embodiments, the top of the mixing tank is communicated with the top of the spiral channel through a second reflux pipe, and the surface of the second reflux pipe is provided with a filter cartridge.
[0010] In some embodiments, a refrigeration assembly is arranged between the two energy storage tanks, the refrigeration assembly comprises a connecting pipe fixed between the two tank bodies and a refrigerator fixed on the inner wall of the connecting pipe, the refrigeration side of the refrigerator faces the energy storage tank for storing the cold source, and the heat dissipation side of the refrigerator faces the energy storage tank for storing the heat source.
[0011] In some embodiments, a temperature sensor for detecting the temperature inside the tank body is fixed on the upper surface of the energy storage tank for storing the heat source, and an electrically controlled heat dissipation pipe for heat dissipation is fixed on the upper surface of the tank body.
[0012] In some embodiments, a closing assembly for alternating the flow directions of the first communication pipe and the second reflux pipe is arranged on the inner top of the mixing tank, the closing assembly comprises a plurality of cover plates for unidirectionally closing the first communication pipe and the second reflux pipe, the plurality of cover plates are rotatable on the inner wall of the mixing tank through a rotating shaft, and a torsion spring for making the cover plates tightly adhere to the inner wall of the mixing tank is arranged on the surface of the rotating shaft.
[0013] In some embodiments, two cover plates for closing the first communication pipe are respectively provided with a lever on the surface thereof, and the cover plate for closing the second reflux pipe is provided with two baffles on the surface thereof, the baffles are L-shaped, and the end of the lever facing the baffle abuts against the inner side of the baffle.
[0014] The application also provides a stability-enhanced microencapsulation treatment method of active ingredients of eucommia seed, comprising the following steps: S1, dissolving chitosan in acetic acid solution, stirring the chitosan solution in the mixing tank at 25°C for 12 hours, and obtaining a chitosan solution; S2, adding Tween 80 into the stirred chitosan aqueous solution, and further stirring at 45°C for 1.5 hours to obtain an aqueous phase; S3, continuously drop the oil phase into the water phase, and use the mixing tank to stir for 30 min at 14000 rpm, 5 DEG C, to form an oil-in-water emulsion; S4, slowly add sodium tripolyphosphate into the emulsion, stir at 3000 rpm, continue to stir for 40 min at room temperature, to induce chitosan ionic gel; S5, add the emulsion into a high-speed centrifuge to precipitate, then wash twice in the high-speed centrifuge with deionized water, centrifuge again, disperse in an ultrasonic disperser and add distilled water to form a uniform suspension; S6, store the suspension in an ultra-low temperature refrigerator, place at-20 DEG C for 24 h, and freeze dry in a vacuum freeze dryer for 72 h to form microcapsules.
[0015] Compared with the prior art, the application provides a stable microencapsulation treatment system and method for active ingredients of eucommia seed, which has the following beneficial effects.
[0016] 1、The energy storage tank is arranged, cold source and heat source are stored in the two energy storage tanks respectively, when the temperature in the mixing tank needs to be regulated, the cold source or heat source stored in the energy storage tank is delivered to the mixing tank, so that the temperature in the mixing tank can be quickly regulated, the temperature regulation time is reduced, the mixing time is reduced, and the homogenization efficiency is improved.
[0017] 2、The heat exchange assembly is arranged, the heat source or cold source is introduced into the heat preservation cover and flows in the spiral channel divided by the spiral partition plate, so that the bottom of the mixing tank is simultaneously temperature-regulated, the heat exchange area of the emulsion is increased, uniform heat exchange is realized, and the required mixing temperature is reached.
[0018] Other advantages, objects, and features of the application will be set forth in part in the following specification taken in conjunction with the accompanying drawings; and in part will become apparent to those skilled in the art upon examination of the following specification and drawings; or can be learned from practice of the application. BRIEF DESCRIPTION OF DRAWINGS
[0019] Figure 1 It is a system flow diagram of the application.
[0020] Figure 2 It is a front view structural diagram of the mixing tank in the application.
[0021] Figure 3 It is a rear view structural diagram of the mixing tank in the application.
[0022] Figure 4 It is a cross-sectional structural diagram of the energy storage tank in the application.
[0023] Figure 5It is a side view structure schematic diagram of the energy storage tank in the application.
[0024] Figure 6 It is a cross-sectional structure schematic diagram of the heat preservation cover in the application.
[0025] Figure 7 It is a partial cross-sectional structure schematic diagram of the heat preservation cover in the application.
[0026] Figure 8 It is a bottom view structure schematic diagram of the mixing tank in the application.
[0027] Figure 9 It is a cross-sectional structure schematic diagram of the mixing tank in the application.
[0028] Figure 10 It is a structure schematic diagram of the A place in the application. Figure 4
[0029] Figure 11 It is a structure schematic diagram of the closed assembly in the application.
[0030] In the figure: 1, mixing tank; 2, high-speed centrifuge; 3, ultrasonic disperser; 4, ultra-low temperature refrigerator; 5, vacuum freeze dryer; 6, energy storage tank; 601, tank body; 602, perforated plate; 603, energy storage ball; 7, communication assembly; 701, first communication pipe; 702, air pump; 703, three-way reversing valve; 8, heat exchange assembly; 801, heat preservation cover; 802, spiral partition; 9, reflux assembly; 901, second communication pipe; 902, first reflux pipe; 903, second reflux pipe; 904, filter cartridge; 10, exhaust pipe; 11, refrigeration assembly; 1101, connecting pipe; 1102, refrigeration machine; 1103, fan; 12, temperature sensor; 13, electric control heat dissipation pipe; 14, closed assembly; 1401, cover plate; 1402, lever; 1403, baffle; 1404, torsional spring. DETAILED DESCRIPTION
[0031] The technical solutions in the embodiments of the application will be clearly and completely described below with reference to the drawings in the embodiments of the application. Obviously, the described embodiments are only part of the embodiments of the application, rather than all the embodiments of the application.
[0032] Referring to Figures 1-11 A stability-enhanced microencapsulation processing system of active ingredients of eucommia seed, comprising a mixing tank 1 for mixing emulsion, a high-speed centrifuge 2 for separating nano-particle precipitate and washing particles, an ultrasonic disperser 3 for forming a uniform suspension, an ultra-low temperature refrigerator 4 for pre-freezing the nano-particle suspension, and a vacuum freeze dryer 5 for freeze-drying the nano-particles.
[0033] It can be understood that, in the preparation of microcapsules, chitosan is dissolved in acetic acid solution, and the mixing tank 1 is stirred at 25°C for 12 hours to obtain a chitosan solution; then, Tween 80 is added to the stirred chitosan aqueous solution, and further stirred at 45°C for 1.5 hours to obtain an aqueous phase; at the same time, the eucommia seed essential oil is dissolved in dichloromethane to form an oil phase; then, the oil phase is continuously dropped into the aqueous phase in the mixing tank 1 at 14000 rpm and 5°C, and stirred for 30 min to form an oil-in-water emulsion; then, sodium tripolyphosphate is slowly added to the emulsion, stirred at 3000 rpm, and continue to stir at room temperature for 40 min to induce chitosan ionic gel; subsequently, the emulsion is added to the high-speed centrifuge 2 for precipitation, and then deionized water is added to the high-speed centrifuge 2 for washing twice, and then centrifuged; then, it is transferred to the ultrasonic disperser 3 and distilled water is added for dispersion to form a uniform suspension; finally, the suspension is stored in the ultra-low temperature refrigerator 4, placed at -20°C for 24h, and then freeze-dried in the vacuum freeze-drier 5 for 72h to form microcapsules; wherein the high-speed centrifuge 2, the ultrasonic disperser 3, the ultra-low temperature refrigerator 4 and the vacuum freeze-drier 5 all adopt the prior art, so they will not be described in detail.
[0034] Specifically, the back of the mixing tank 1 is provided with two groups of energy storage tanks 6 for providing heat source and cold source respectively, the energy storage tank 6 includes a tank body 601 and a perforated plate 602 fixed inside the tank body 601, a plurality of energy storage balls 603 are stacked above the perforated plate 602, the energy storage ball 603 is a hollow metal ball, and the perforated plate 602 is spaced apart from the bottom of the tank body 601 by a cavity.
[0035] It can be understood that, by arranging the energy storage tank 6, the cold source and the heat source are stored in the two energy storage tanks 6 respectively, and when the temperature in the mixing tank 1 needs to be regulated, the cold source or the heat source stored in the energy storage tank 6 is delivered to the mixing tank 1, so that the temperature in the mixing tank 1 can be quickly regulated, the temperature regulation time is reduced, the mixing time is reduced, and the homogenization efficiency is improved; by arranging a plurality of energy storage balls 603, more heat source or cold source can be stored, by arranging a cavity at the bottom of the tank body 601 through the perforated plate 602, the heat source or the cold source can be easily stored in the energy storage tank 6 from the cavity, and under the action of the perforated plate 602, the heat source or the cold source is transmitted upward to the surface of the plurality of energy storage balls 603 for energy storage, and the gaps between the energy storage balls 603 can make the air circulate to transmit the heat source or the cold source.
[0036] Specifically, the energy storage tank 6 is communicated with the top of the mixing tank 1 through the communication assembly 7, the communication assembly 7 includes a first communication pipe 701 fixed on the top of the mixing tank 1 and an air pump 702 fixed on the lower end of the first communication pipe 701, the air inlet of the air pump 702 is communicated with a three-way reversing valve 703, one end of the three-way reversing valve 703 is communicated with the top of the tank body 601, and the other end of the three-way reversing valve 703 is used for extracting normal temperature air.
[0037] It can be understood that by arranging the communication assembly 7, when the temperature of the mixing tank 1 needs to be regulated, the air pump 702 works to extract the heat source or cold source in the tank body 601 into the mixing tank 1, so that the temperature regulation is quickly performed. When rapid heating or rapid cooling is needed, first, the air inlet of the three-way reversing valve 703 is adjusted to the end communicated with the outside, so that the air pump 702 transports the normal temperature air from the outside to the mixing tank 1 for temperature neutralization, and then the cold source or heat source is transported to the mixing tank 1 through the adjustment of the three-way reversing valve 703 for temperature regulation, thereby avoiding the waste of the heat source or cold source and achieving the purpose of energy saving.
[0038] Specifically, the mixing tank 1 is fixed with a heat exchange assembly 8 for keeping the temperature of the mixing tank 1 uniform, the heat exchange assembly 8 includes a heat preservation cover 801 fixed on the surface of the mixing tank 1 and a spiral partition plate 802 fixed on the inner wall of the heat preservation cover 801, the heat preservation cover 801 wraps the mixing tank 1, and the spiral partition plate 802 divides a spiral channel between the heat preservation cover 801 and the mixing tank 1, and the top of the heat preservation cover 801 is flush with the height of the maximum stirring capacity of the mixing tank 1.
[0039] It can be understood that if only the heat source or cold source is transported into the mixing tank 1, only the temperature of the top of the mixing tank 1 can be regulated, the contact area with the emulsion is small, and the temperature of the emulsion at the bottom of the mixing tank 1 cannot reach the required temperature, which affects the stability of the active ingredients of the eucommia seed. Therefore, the heat exchange assembly 8 is arranged, the heat source or cold source is transported into the heat preservation cover 801 and flows in the spiral channel divided by the spiral partition plate 802, so that the bottom of the mixing tank 1 is simultaneously regulated, the heat exchange area of the emulsion is increased, the emulsion is uniformly heat exchanged, and the required mixing temperature is reached.
[0040] Specifically, the mixing tank 1 is provided with a reflux assembly 9 for flowing of the heat source or cold source, the reflux assembly 9 includes two second communication pipes 901 communicated with the heat preservation cover 801, the other ends of the two second communication pipes 901 are respectively communicated with the two first communication pipes 701, the second communication pipes 901 are communicated with the top of the spiral channel through the heat preservation cover 801, the reflux assembly 9 further includes two first reflux pipes 902 for refluxing the heat source and the cold source into the two energy storage tanks 6 respectively, one end of each of the two first reflux pipes 902 is communicated with the bottom of the spiral channel through the heat preservation cover 801, the other end of each of the two first reflux pipes 902 is communicated with the bottom of the two energy storage tanks 6, and an electromagnetic valve is arranged on the surface of each of the two first reflux pipes 902. The top of the mixing tank 1 is communicated with a second reflux pipe 903, the other end of the second reflux pipe 903 is communicated with the top of the spiral channel through a heat preservation cover 801, and a filter cartridge 904 is arranged on the surface of the second reflux pipe 903.
[0041] It can be understood that, by arranging the second communication pipe 901, when the first communication pipe 701 transports the heat source or the cold source into the mixing tank 1, part of the heat source or the cold source is transported into the heat preservation cover 801 through the second communication pipe 901, and the spiral channel can fully exchange heat with the emulsion in the mixing tank 1, so that the purpose of uniform temperature adjustment is achieved; by arranging the second reflux pipe 903, the excess heat source or the cold source in the mixing tank 1 is transported into the heat preservation cover 801 through the second reflux pipe 903, and then is returned to the corresponding energy storage tank 6 through the first reflux pipe 902 at the bottom of the heat preservation cover 801, so that the purpose of circulating flow is achieved; and by arranging the filter cartridge 904, the heat source or the cold source discharged from the mixing tank 1 is filtered.
[0042] Specifically, an exhaust pipe 10 is fixed at the bottom of the heat preservation cover 801, the exhaust pipe 10 is communicated with the bottom of the spiral channel, and an electromagnetic valve is arranged on the surface of the exhaust pipe 10.
[0043] It can be understood that, by arranging the exhaust pipe 10, when external air is used for temperature neutralization, the external air is discharged through the exhaust pipe 10, so as to avoid entering the energy storage tank 6 and causing loss of the heat source or the cold source.
[0044] Specifically, a refrigeration assembly 11 is arranged between the two energy storage tanks 6, the refrigeration assembly 11 comprises a connecting pipe 1101 fixed between the two tank bodies 601 and a refrigerating machine 1102 fixed on the inner wall of the connecting pipe 1101, the refrigerating side of the refrigerating machine 1102 faces the energy storage tank 6 for storing the cold source, the heat dissipation side of the refrigerating machine 1102 faces the energy storage tank 6 for storing the heat source, two fans 1103 are fixed on the inner wall of the connecting pipe 1101, and the two fans 1103 are respectively located on the two sides of the refrigerating machine 1102.
[0045] It can be understood that, by arranging the refrigerating machine 1102, the refrigerating machine 1102 also generates heat during refrigeration, therefore, the cold air generated by the refrigerating machine 1102 is transported into the energy storage tank 6 through the fan 1103 for storage, and the heat generated by the refrigerating machine 1102 is dissipated through the heat dissipation fin and is transported into the other energy storage tank 6 under the action of the fan 1103 for storage, since the heat required for stirring the emulsion is small, therefore, after the heat source generated by the refrigerating machine 1102 is collected, it is sufficient to meet the use.
[0046] Specifically, a temperature sensor 12 for detecting the temperature inside the tank body 601 is fixed on the upper surface of the energy storage tank 6 for storing the heat source, and an electrically controlled heat dissipation pipe 13 for heat dissipation is fixed on the upper surface of the tank body 601.
[0047] It can be understood that, in order to avoid the temperature inside the energy storage tank 6 storing the heat source being too high to affect the operation of the refrigerator 1102, a temperature sensor 12 is arranged to monitor the temperature inside the tank body 601, and when the temperature inside the tank body 601 exceeds a preset value, the tank body 601 is communicated with the outside through the electrically controlled heat dissipation pipe 13 to discharge the excess heat, so as to avoid the temperature inside the tank body 601 being too high.
[0048] Specifically, the mixing tank 1 is provided with a closing assembly 14 at the top for alternating the flow directions of the first communication pipes 701 and the second return pipes 903. The closing assembly 14 includes a plurality of cover plates 1401 for unidirectionally closing the first communication pipes 701 and the second return pipes 903. The plurality of cover plates 1401 are rotatable on the inner wall of the mixing tank 1 through a rotating shaft. A torsion spring 1404 is arranged on the surface of the rotating shaft to make the cover plates 1401 tightly adhere to the inner wall of the mixing tank 1. Two lever rods 1402 are fixed on the surfaces of the two cover plates 1401 for closing the first communication pipes 701. Two baffles 1403 are fixed on the surfaces of the cover plates 1401 for closing the second return pipes 903. The baffles 1403 are L-shaped, and the ends of the lever rods 1402 facing the baffles 1403 abut against the inner sides of the baffles 1403.
[0049] It can be understood that, by arranging a plurality of cover plates 1401, the two first communication pipes 701 and the second return pipes 903 are closed, so as to avoid the emulsion from splashing into the first communication pipes 701 and the second return pipes 903 when the temperature is not controlled. When the first communication pipes 701 are discharged, the air pressure drives the cover plates 1401 to rotate, so that the cover plates 1401 are automatically opened. When the cover plates 1401 closing the first communication pipes 701 rotate, the lever rods 1402 are driven to rotate, so that the lever rods 1402 drive the baffles 1403 and the cover plates 1401 closing the second return pipes 903 to open, so that the excess air in the mixing tank 1 is discharged through the second return pipes 903.
[0050] The embodiment also provides a method for enhancing the stability of the active ingredients of eucommia seed, comprising the following steps: S1, dissolving chitosan in acetic acid solution, stirring in the mixing tank 1 at 25°C for 12 hours to obtain a chitosan solution. Before stirring, the cold air generated by the refrigerator 1102 is delivered to the energy storage tank 6 through the fan 1103 for storage. During stirring, the air pump 702 is operated to extract the cold source in the tank body 601 into the mixing tank 1 and the heat preservation cover 801, so as to continuously lower the temperature in the mixing tank 1 and keep it at 25°C. S2, add Tween 80 to the stirred chitosan aqueous solution, further stir at 45°C for 1.5 hours to obtain the water phase; before adding Tween 80, use the air pump 702 above the energy storage tank 6 for storing heat source to make the air pump 702 deliver the normal temperature air from outside to the mixing tank 1 for temperature neutralization, then use the three-way reversing valve 703 to connect the first communication pipe 701 with the tank body 601, extract the heat source stored in the tank body 601 to the mixing tank 1 to quickly raise the temperature to 45°C; S3, continuously drop the oil phase into the water phase, and use the mixing tank 1 to stir at 14000 rpm and 5°C for 30 min to form an oil-in-water emulsion; during temperature adjustment, quickly adjust the temperature in the mixing tank 1 according to the temperature adjustment mode in S2; S4, slowly add sodium tripolyphosphate to the emulsion, stir at 3000 rpm, and continue to stir at room temperature for 40 min to induce chitosan ionic gel; S5, add the emulsion to the high-speed centrifuge 2 for precipitation, then add deionized water to the high-speed centrifuge 2 for washing twice, centrifuge again, disperse in the ultrasonic disperser 3 and add distilled water to form a uniform suspension; S6, store the suspension in the ultra-low temperature refrigerator 4, place at -20°C for 24 h, and freeze dry in the vacuum freeze dryer 5 for 72 h to form microcapsules.
[0051] In the present application, the chitosan is dissolved in acetic acid solution, and the refrigerator 1102 is operated. The refrigerator 1102 also generates heat during refrigeration. Therefore, the cold air generated by the refrigerator 1102 is delivered to the energy storage tank 6 by the fan 1103 for storage, and the heat generated by the refrigerator 1102 is dissipated by the heat dissipation fins and delivered to another energy storage tank 6 by the fan 1103 for storage. The multiple energy storage balls 603 can increase the storage capacity. By operating the air pump 702 above the energy storage tube storing the cold source, the cold source in the tank body 601 is extracted to the mixing tank 1 and the heat preservation cover 801 through the first communication pipe 701, continuously cooling the temperature in the mixing tank 1, and making the cold source return to the energy storage tube through the first return pipe 902 connected with the cold source energy storage tank 6, achieving the purpose of circulating flow and keeping at 25°C. The chitosan solution is obtained by stirring the mixing tank 1 at 25°C for 12 hours. Then, the first return pipe 902 on the cold source energy storage tank 6 is closed by the electromagnetic valve. The air pump 702 above the energy storage tank 6 for storing the heat source is operated, so that the air pump 702 delivers the normal temperature air outside to the mixing tank 1 and the heat preservation cover 801 for temperature neutralization, and discharges through the exhaust pipe 10. Then, the three-way reversing valve 703 is used to connect the first communication pipe 701 with the tank body 601, so that the heat source stored in the tank body 601 is extracted to the mixing tank 1 and the heat preservation cover 801, and returns to the energy storage tube through the first return pipe 902 on the heat source energy storage tank 6, achieving the purpose of circulation and rapidly increasing the temperature to 45°C. The Tween 80 is added dropwise to the stirred chitosan aqueous solution, and further stirred at 45°C for 1.5 hours to obtain the water phase. Then, the temperature is adjusted again according to the above method, the temperature in the mixing tank 1 is adjusted to 5°C, the oil phase is continuously added to the water phase, and the mixing tank 1 is stirred at 14000 rpm for 30 min to form an oil-in-water emulsion. Then, the sodium tripolyphosphate is slowly added to the emulsion, stirred at 3000 rpm, and continuously stirred at room temperature for 40 min to induce chitosan ionic gel. Then, the emulsion is added to the high-speed centrifuge 2 for precipitation, and then deionized water is added to the high-speed centrifuge 2 for washing twice, and then centrifuged, dispersed in the ultrasonic disperser 3, and distilled water is added to form a uniform suspension. Then, the suspension is stored in the ultra-low temperature refrigerator 4, placed at-20°C for 24h, and freeze-dried in the vacuum freeze dryer 5 for 72h to form microcapsules.
[0052] The above description is only a preferred embodiment of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art can make equivalent replacements or changes to the technical solution and the inventive concept of the present application within the technical range disclosed by the present application, which should be covered within the protection scope of the present application.
[0053] In the description of the specification, the description of the terms "one embodiment", "some embodiments", "an example", "a specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are contained in at least one embodiment or example of the present application. In the specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any suitable manner in any one or more embodiments or examples. In addition, the person skilled in the art can combine and combine the different embodiments or examples described in the specification and the features of the different embodiments or examples without contradiction.
[0054] Although the embodiments of the present application have been shown and described above, it is understood that the above-described embodiments are exemplary and are not to be construed as limiting the present application, and those skilled in the art can make changes, modifications, replacements and variations to the above-described embodiments within the scope of the present application.
Claims
1. A system for the stability-enhanced microencapsulation of active ingredients of eucommia ulmoides oliver seeds, characterized in that, The application relates to a mixing tank (1) for mixing emulsion, which is provided with two groups of energy storage tanks (6) for providing heat source and cold source respectively at the back of the mixing tank (1), the energy storage tanks (6) are communicated with the top of the mixing tank (1) through a communicating assembly (7), and a heat exchange assembly (8) for keeping the temperature of the mixing tank (1) uniform is fixed on the surface of the mixing tank (1). The energy storage tank (6) comprises a tank body (601) and a porous plate (602) fixed in the tank body (601), and a plurality of energy storage balls (603) are stacked above the porous plate (602).
2. The system for the stability-enhanced microencapsulation of active ingredients from eucommia ulmoides oliver seeds according to claim 1, characterized in that, The communicating assembly (7) comprises a first communicating pipe (701) fixed on the top of the mixing tank (1) and an air pump (702) fixed on the lower end of the first communicating pipe (701), the air inlet of the air pump (702) is communicated with the top of the tank body (601) through a three-way reversing valve (703), and the other end of the three-way reversing valve (703) is used for extracting normal-temperature air.
3. The system for the stability-enhanced microencapsulation of active ingredients of eucommia ulmoides oliver seeds according to claim 1, characterized in that, The heat exchange assembly (8) comprises a heat preservation cover (801) fixed on the surface of the mixing tank (1) and a spiral partition plate (802) fixed on the inner wall of the heat preservation cover (801), the heat preservation cover (801) wraps the mixing tank (1), and the spiral partition plate (802) divides a spiral channel between the heat preservation cover (801) and the mixing tank (1).
4. The system for the stability-enhanced microencapsulation of active ingredients from eucommia ulmoides oliver seeds according to claim 1, characterized in that, The surface of the mixing tank (1) is provided with a backflow assembly (9) for circulating the heat source or the cold source, the backflow assembly (9) comprises two second communicating pipes (901) for communicating the heat preservation cover (801) with two first communicating pipes (701), and the backflow assembly (9) further comprises two first backflow pipes (902) for respectively backflowing the heat source and the cold source into two energy storage tanks (6).
5. The system for the stability-enhanced microencapsulation of active eucommia seed ingredients according to claim 4, characterized in that, The top of the mixing tank (1) is communicated with the top of the spiral channel through a second backflow pipe (903), and a filter cartridge (904) is arranged on the surface of the second backflow pipe (903) in communication.
6. The system for the stability-enhanced microencapsulation of active eucommia seed ingredients according to claim 1, characterized in that, A refrigeration assembly (11) is arranged between the two energy storage tanks (6), the refrigeration assembly (11) comprises a connecting pipe (1101) fixed between the two tank bodies (601) and a refrigeration machine (1102) fixed on the inner wall of the connecting pipe (1101), one side of the refrigeration machine (1102) is used for storing the cold source, and the other side of the refrigeration machine (1102) is used for storing the heat source.
7. The system for the stability-enhanced microencapsulation of active eucommia seed ingredients according to claim 1, characterized in that, A temperature sensor (12) for detecting the temperature in the tank body (601) is fixed on the upper surface of the energy storage tank (6) for storing the heat source, and an electrically-controlled heat dissipation pipe (13) for heat dissipation is fixed on the upper surface of the tank body (601).
8. The system for the stability-enhanced microencapsulation of active eucommia seed ingredients according to claim 1, characterized in that, The mixing tank (1) is provided with a closing assembly (14) for alternating the flow direction of the first communication pipe (701) and the second return pipe (903) on the inner top, the closing assembly (14) comprises a plurality of cover plates (1401) for one-way closing of the first communication pipe (701) and the second return pipe (903), and the plurality of cover plates (1401) are rotated on the inner wall of the mixing tank (1) through a rotating shaft, and the surface of the rotating shaft is sleeved with a torsion spring (1404) for making the cover plate (1401) tightly adhere to the inner wall of the mixing tank (1).
9. The system for the stability-enhanced microencapsulation of active eucommia seed ingredients according to claim 8, characterized in that, The surface of two cover plates (1401) for closing the first communication pipe (701) is respectively fixed with a lever (1402), and the surface of the cover plate (1401) for closing the second return pipe (903) is fixed with two baffles (1403), the baffles (1403) are L-shaped, and the end of the lever (1402) towards the baffle (1403) abuts against the inner side of the baffle (1403).
10. A method for the enhanced stability microencapsulation of active ingredients from Eucommia ulmoides Oliver seeds, based on the system for the enhanced stability microencapsulation of active ingredients from Eucommia ulmoides Oliver seeds according to any one of claims 1 to 9, characterized in that, The method comprises the following steps: S1, dissolving chitosan in acetic acid solution, stirring in the mixing tank (1) at 25°C for 12 hours to obtain a chitosan solution; S2, adding Tween 80 to the stirred chitosan aqueous solution, and further stirring at 45°C for 1.5 hours to obtain an aqueous phase; S3, continuously dropping the oil phase into the aqueous phase, and stirring in the mixing tank (1) at 14000 rpm and 5°C for 30 min to form an oil-in-water emulsion; S4, slowly adding sodium tripolyphosphate to the emulsion, stirring at 3000 rpm, and continuing to stir at room temperature for 40 min to induce chitosan ionic gel; S5, adding the emulsion into a high-speed centrifuge (2) for precipitation, then adding deionized water into the high-speed centrifuge (2) for washing twice, and then centrifuging, dispersing in an ultrasonic disperser (3) and adding distilled water to form a uniform suspension; S6, storing the suspension in an ultra-low temperature refrigerator (4), placing at -20°C for 24h, and freeze-drying in a vacuum freeze dryer (5) for 72h to form microcapsules.