Non-contact infectious disease pathogen detection equipment

Abstract

The present invention relates to the field of detection equipment, and discloses non-contact infectious disease pathogen detection equipment, which comprises: a detection box body, the top of which is provided with a liquid box for storing a detection liquid; and the detection bracket is arranged in the detection box body. The rotary heating operation is set in the transition stage from descending to releasing after the container receives liquid, so that sequential coupling of structural action and mixing treatment is realized, extra waiting time and independent control steps are avoided, and the operating efficiency of the device is remarkably improved. The detection part controls the liquid to be accurately released between the container and the test paper, quantitative reaction on the test paper is achieved, and the detection consistency is improved. The replaceable design of the detection plate is matched with multiple times of dropwise adding, so that efficient circulation of single-time liquid taking and multi-batch detection is formed, and manual intervention and sample transfer are reduced. The whole structure is closed and free of contact, cross contamination and aerosol leakage can be effectively avoided, the biological safety of pathogen detection is improved, and the device is suitable for a high-risk pathogen screening environment.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of detection equipment, and particularly relates to a non-contact infectious disease pathogen detection equipment. BACKGROUND

[0002] In the process of laboratory pathogen detection, the pretreatment operation for infectious samples usually includes: adding a pathogen liquid sample into a treatment container, then adding a lysis solution or buffer solution into the container, and then mixing and heating the sample to realize the lysis, inactivation or antigen release of the pathogen. This treatment process is a key prerequisite for downstream antigen recognition and other detection reactions.

[0003] In the process of laboratory pathogen detection, the pretreatment operation for infectious samples usually includes: adding a pathogen liquid sample into a treatment container, then adding a lysis solution or buffer solution into the container, and then mixing and heating the sample to realize the lysis, inactivation or antigen release of the pathogen. This treatment process is a key prerequisite for downstream antigen recognition and other detection reactions. SUMMARY

[0004] In view of the defects of the prior art, the present application provides a non-contact infectious disease pathogen detection equipment, which aims to at least alleviate the above problems to some extent.

[0005] The above technical purpose of the present application is realized by the following technical scheme: A non-contact infectious disease pathogen detection equipment, comprising: A detection box body, a liquid tank for storing detection liquid is arranged on the top of the detection box body; A detection support arranged in the detection box body, a plurality of containers are arranged on the detection support; A detection plate arranged on the detection box body, the detection plate is inserted into the detection box body and located below the containers, the detection box body is located above the containers, and a plurality of insertion interfaces are arranged on the side wall of the detection plate for inserting test papers; A detection component arranged on the container, for receiving the liquid in the liquid tank and releasing on the surface of the test paper of the detection plate; A moving component arranged between the detection box body and the detection support, for moving the detection support and the containers thereon up and down; A pretreatment component arranged between the detection support and the containers, for rotating and heating the containers when the containers are moved up and down.

[0006] Preferably, the moving component comprises a screw rod rotatably connected to the detection box, and a servo motor is arranged on the detection box, and a driving shaft of the servo motor is connected to the screw rod.

[0007] Preferably, a liquid receiving port is arranged on the top of the test paper, and the liquid receiving port is communicated with the insertion port, and the insertion port is arranged in an inclined manner.

[0008] Preferably, the pretreatment component comprises a gear connected to the container, and a rack engaged with the gear is slidably connected to the detection support.

[0009] Preferably, the pretreatment component further comprises a mounting port arranged on the detection support, the container is rotatably arranged in the mounting port, an inner wall of the mounting port is provided with a heating cavity, and an electric heating wire is arranged in the heating cavity.

[0010] Preferably, the pretreatment component further comprises two convex strips connected to the detection box, the convex strips are provided with a plurality of arc-shaped convex parts, and two sections of the rack are respectively rotatably connected with rollers in contact with the convex strips.

[0011] Preferably, a plurality of disturbance pieces are fixedly connected to the inner wall of the container.

[0012] Preferably, the container receives liquid when moving upward to the liquid tank position, and releases liquid when moving downward to the detection plate position, and the released liquid is a preset amount. The detection component comprises a trigger tube slidably connected to the bottom of the container, a spring a is connected between the trigger tube and the container, an inner wall of the trigger tube is provided with a blocking ring, a release tube a is arranged in the container, a release cavity is formed in the release tube a, a liquid inlet channel and a liquid outlet channel are arranged on the release cavity, the liquid inlet channel is communicated with the container, and the liquid outlet channel corresponds to the position of the blocking ring.

[0013] Preferably, the detection component further comprises a liquid inlet tube slidably connected to the top of the container, a spring b is connected between the liquid inlet tube and the container, a liquid supplement channel is arranged on the outer wall of the liquid inlet tube, a release tube b is communicated with the bottom of the liquid tank, a connecting ring is slidably arranged on the outer wall of the release tube b, a spring c is connected between the connecting ring and the liquid tank, and a release port corresponding to the connecting ring is arranged on the outer wall of the release tube b.

[0014] Preferably, after the container receives liquid, a plurality of batches of test papers can be released multiple times, and the liquid is mixed once before and after each release. The detection component further comprises a connecting frame fixed in the container, a release pipe a is rotationally connected to the connecting frame, a spiral opening is formed in the outer wall of the release pipe a, the top of the trigger pipe is connected with a guide rod matched with the spiral opening, the top of the release pipe a is connected with a rotating shaft, and a plurality of blades are arranged on the rotating shaft.

[0015] In summary, the present application mainly has the following beneficial effects: The present application realizes integrated control of the whole process of liquid receiving, sample pretreatment, step-by-step release and test paper detection in the process of pathogen detection through the organic cooperation of the detection box, the liquid tank, the detection support, the container, the detection plate, the detection component, the moving component and the pretreatment component. The container can continuously release a plurality of test papers after taking liquid once, and the liquid in the container is mixed once before and after each release, so that the liquid does not settle or stratify during standing, and the reaction components are uniform and active. The setting significantly improves the stability and repeatability of the detection reaction, reduces the waste of detection liquid, eliminates the operation complexity brought by frequent liquid receiving, and is suitable for high-throughput detection tasks.

[0016] The present application realizes the time sequence coupling of structure action and mixing treatment by setting the rotary heating operation in the transition stage after the container receives liquid and before release, avoids additional waiting time and independent control steps, and significantly improves the device running efficiency. The detection component controls the accurate release of liquid between the container and the test paper, realizes the quantitative reaction on the test paper, and improves the detection consistency. The detection plate can be designed to be extracted and replaced to form an efficient cycle of single liquid taking and multiple batch detection, reducing manual intervention and sample transfer. The overall structure is closed and contactless, which can effectively avoid cross contamination and aerosol leakage, improve the biological safety of pathogen detection, and is suitable for high-risk pathogen screening environment. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 is a schematic diagram of the overall structure of the present application; Figure 2 is a sectional view of the overall structure of the present application; Figure 3 is a schematic diagram of the detection plate structure of the present application; Figure 4 is a schematic diagram of the detection support structure of the present application; Figure 5 is a sectional view of the container structure of the present application; Figure 6 is Figure 5 is an enlarged schematic diagram of the local structure at A in the above figure; Figure 7 is Figure 5 is an enlarged schematic diagram of the local structure at B in the above figure; Figure 8It is a structure schematic diagram of the release pipe a of the present application.

[0018] Reference signs: 100, detection box; 101, liquid tank; 102, detection support; 103, container; 104, detection plate; 105, plug interface; 106, screw; 107, servo motor; 108, liquid outlet; 200, gear; 201, rack; 202, mounting port; 203, heating cavity; 204, heating wire; 205, convex strip; 206, protruding part; 207, roller; 208, disturbing piece; 300, trigger pipe; 301, spring a; 302, blocking ring; 303, release pipe a; 304, release cavity; 305, liquid inlet channel; 306, liquid outlet channel; 307, liquid inlet pipe; 308, spring b; 309, liquid supplement channel; 310, release pipe b; 311, connecting ring; 312, spring c; 313, release port; 400, connecting frame; 401, spiral port; 402, guide rod; 403, rotating shaft; 404, blade. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0020] Reference Figures 1-8 The present embodiment provides a non-contact infectious disease pathogen detection device, which comprises the following main structural components: a detection box 100, a liquid tank 101, a detection support 102, a container 103, a detection plate 104, a detection component, a moving component, and a pretreatment component.

[0021] The detection box 100 is a support shell with an overall structure, used for accommodating internal components and defining their relative positions. The detection box 100 is a hollow cavity structure, the top of which is used to mount the liquid tank 101, the internal space of which is used to arrange the detection support 102 and the container 103 above it, and the front side of which is provided with a plug-in groove structure for inserting the detection plate 104.

[0022] The liquid tank 101 is arranged on the top of the detection box 100 and is a fixed structure, used for storing the liquid required in the detection process. A liquid outlet corresponding to the upper part of the container 103 is arranged below the liquid tank 101, so that when the container 103 moves up to a predetermined position below the liquid tank 101, the liquid tank 101 supplies liquid to the container 103 through the liquid outlet.

[0023] The detection support 102 is arranged inside the detection box 100 and is located below the liquid tank 101. The detection support 102 is provided with a plurality of containers 103. The detection support 102 can drive the containers 103 to move up and down along the vertical direction under the driving of the moving component.

[0024] The containers 103 can be arranged horizontally. Each container 103 has the ability to receive and release liquid. The upper end of the container 103 faces the direction of the liquid tank 101 for receiving liquid, and the lower end faces the direction of the detection plate 104 for releasing liquid. The inside of each container 103 is used for temporarily storing liquid, and the bottom is provided with a controllable release structure, and the release process is controlled by the detection component arranged thereon.

[0025] The detection plate 104 is arranged on the detection box 100 and is inserted into the detection box 100 through the slot structure and is located directly below the container 103. The detection plate 104 is a pull-out structure, which is convenient for plugging and replacing. The side wall of the detection plate 104 is provided with a plurality of plug-in interfaces 105, and each plug-in interface 105 is used for inserting a piece of test paper. After the container 103 is lowered to the preset position, the bottom outlet thereof is opposite to the corresponding test paper position, so as to realize the liquid point release.

[0026] The detection component is installed on each container 103 and is used for controlling the release action of the liquid. After the container 103 moves upward to the predetermined position of the bottom of the liquid tank 101 with the detection support 102, the detection component cooperates with the liquid outlet structure of the liquid tank 101 to receive liquid. After the container 103 completes the liquid receiving, the detection support 102 moves downward to the corresponding position of the detection plate 104, and when reaching the predetermined release height, the detection component controls the release of a preset amount of liquid to the surface of the test paper.

[0027] The moving component is arranged between the detection box 100 and the detection support 102 and is used for driving the detection support 102 to move up and down in the vertical direction, so as to drive the container 103 to complete the liquid receiving and liquid releasing process. The action of the moving component includes: moving the detection support 102 and the container 103 thereon upward to the liquid receiving position of the liquid tank 101, moving downward to the release position of the detection plate 104, and repeatedly moving up and down at the low position to realize the step-by-step release.

[0028] The pretreatment component is arranged between the detection support 102 and the container 103 and is specifically used for driving the container 103 to rotate and heat during the upward and downward movement of the container 103 with the detection support 102.

[0029] In addition, the detection component controls the liquid in the container 103 to be mixed once before and after each release of liquid, so as to improve the uniformity of the liquid.

[0030] Through the above arrangement, the non-contact infectious disease pathogen detection device described in the embodiment relies on the cooperative matching between the detection box 100, the liquid tank 101, the detection support 102, the container 103, the detection plate 104, the detection component, the moving component, and the pretreatment component to complete the whole process of receiving, mixing, step-by-step releasing, and multiple batches of test paper detection of the liquid, and has the remarkable advantages of high operation safety, strong automation, and good detection repeatability.

[0031] In the actual working process, first, the detection liquid is put into the liquid tank 101. The detection liquid can include sample liquid, lysis liquid, buffer liquid, or other pretreatment liquids suitable for pathogen detection, and the specific components can be configured according to the detection scheme. A plurality of test papers are inserted on the detection plate 104, including but not limited to: Immune chromatography test paper, used for detecting antigens or antibodies in samples, usually composed of nitrocellulose membrane, binding pad, and absorption pad, can realize color development reaction of colloidal gold, fluorescence, or enzyme label; Nucleic acid detection test paper, which is pre-installed with nucleic acid probes or amplification reaction substrates, is suitable for isothermal amplification (such as LAMP) or nucleic acid capture detection; Multi-component detection test paper, which has multiple detection zones or control zones, supports parallel detection of different pathogen antigens, nucleic acids, or antibodies; Chromatographic reaction test paper, which realizes the diffusion and reaction of mixed liquid on the test paper through capillary action, and finally forms a visible signal in a specific area.

[0032] The test papers are inserted into the insertion interfaces 105 of the side walls of the detection plate 104, and each test paper corresponds to the lower end liquid outlet of a container 103 to receive the release of mixed liquid and complete the pathogen recognition reaction on the surface of the test paper. The detected objects can include viruses, bacteria, mycoplasma, chlamydia, or their corresponding nucleic acids, antigens, antibody components, etc.

[0033] During detection, the moving component drives the detection support 102 and the plurality of containers 103 arranged thereon to move upward along the vertical direction until the upper end surface of the container 103 is butted against the liquid outlet structure at the bottom of the liquid tank 101. The detection component arranged on the container 103 is opened in cooperation with the liquid outlet structure of the liquid tank 101, which can control the liquid to enter the inner cavity of the container 103 to realize automatic injection of the liquid. This design can effectively avoid the risk of aerosol and cross contamination in the manual drop process, and significantly improve the biological safety level of the pathogen detection operation in the laboratory.

[0034] After the detection liquid in the liquid tank 101 is received by the container 103, the moving component drives the detection support 102 and the container 103 thereon to move downward along the vertical direction, so that the container 103 gradually approaches the preset release position of the detection plate 104. During the downward movement, the pretreatment component starts to perform rotation and heating operations on the container 103, so as to sufficiently mix the mixed liquid in the container 103. The rotation can disturb the liquid in the container 103, so as to break the possible chromatography or component deposition in the liquid. The heating process can help to activate the chemical components in the detection liquid, accelerate the pathogen lysis or antigen release, and thus significantly improve the reaction efficiency and detection sensitivity of the subsequent reaction. The operation is performed before the liquid is released, and the short window during the downward movement of the detection support 102 is used to quickly and sufficiently mix the liquid just received in the container 103 with the original pathogen sample liquid, so as to significantly improve the overall processing efficiency and compactness of the operation rhythm of the device.

[0035] The moving component drives the container 103 to reach the release position above the detection plate 104. At this time, the liquid outlet structure at the bottom of the container 103 is opposite to the inserted test paper area on the detection plate 104. After the detection plate 104 is contacted, the release structure is opened under the control of the detection component, and a preset amount of liquid is released to the surface of the test paper. The operation realizes accurate and quantitative liquid addition, and can ensure the consistency of the volume of the reagent received by each test paper, so as to enhance the stability and repeatability of the detection data.

[0036] In order to further improve the reaction consistency of the liquid in the multiple release processes, the detection component controls the liquid in the container 103 to be mixed before and after each release of the liquid. The mixing operation makes the liquid in the container 103 keep uniform composition and consistent reaction activity before and after the release, and effectively avoids the component sedimentation or concentration stratification caused by long-term standing. The design significantly improves the chemical stability and reaction reliability of the pathogen lysis liquid or antigen release liquid in the multiple release processes.

[0037] After the liquid is released on the test paper and the test paper detects the liquid, the detection plate 104 can be pulled out and the test paper can be replaced. After the new test paper is inserted, the moving component can drive the container 103 to complete a short downward movement again, the detection component controls the liquid to be released again, and the detection process of the next batch of test papers is performed. Under the premise that the liquid in the container 103 is not consumed, the detection support 102 can continuously perform multiple release operations, and the mixing process is performed between each release, so as to realize the efficient detection cycle of single liquid taking and multiple uses, reduce the reagent waste, and improve the operation efficiency. When the liquid in the container 103 is consumed, the moving component drives the detection support 102 to move upward again, the container 103 is reconnected to the liquid tank 101 to complete a new liquid taking operation, and enters the next cycle.

[0038] Overall, the device highly integrates the steps of liquid receiving, mixing, releasing, test paper replacement, etc. in the same device structure, without the need for sample transfer between multiple devices, avoiding the problems of high experimental intensity and high pollution risk caused by repeated opening of the cover and transfer of the container 103 in the prior art, and being suitable for infectious disease experimental environments with biological safety requirements.

[0039] In the embodiment, the moving component is used to drive the detection support 102 and the container 103 thereon to move up and down in the vertical direction, so as to complete the switching between the liquid receiving and releasing positions. Specifically, the moving component includes a lead screw 106 and a servo motor 107, wherein one end of the lead screw 106 is rotationally connected to the detection box 100, and is used to provide a lifting track in the vertical direction. The detection box 100 is provided with the servo motor 107, and the drive shaft of the servo motor 107 is connected with the lead screw 106, thereby constituting a power output mechanism.

[0040] Through the above arrangement, during the operation of the device, the servo motor 107 starts to operate after receiving a control instruction, and the drive shaft of the servo motor 107 drives the lead screw 106 connected to the detection box 100 to rotate. The lead screw 106 is connected with the detection support 102 through a screw transmission mechanism, so as to convert the rotary motion into linear lifting motion of the detection support 102, thereby driving the plurality of containers 103 thereon to move up and down in the vertical direction. The precise control and stable driving of the movement of the detection support 102 are realized. The servo motor 107 has high response and high-precision closed-loop control capability, and in combination with the high transmission efficiency of the lead screw 106 structure, the positioning accuracy, movement stability and repeatability of the containers 103 between the liquid receiving and releasing positions can be effectively guaranteed.

[0041] In the embodiment, in order to ensure that the liquid released from the container 103 can accurately, quickly and sufficiently enter the test paper reaction area, the top of the test paper is provided with a liquid receiving port 108, which is in communication with a plug-in port 105 arranged on the detection plate 104. The plug-in port 105 is arranged obliquely relative to the horizontal plane of the detection plate 104, and forms a certain angle, so that the test paper is in a slight inclination state after being inserted.

[0042] Through the above arrangement, the liquid released from the container 103 can directly flow into the liquid receiving port 108 at the top of the test paper under the action of gravity, and rapidly spread to the test paper reaction area under the cooperation of the capillary adsorption mechanism. The inclination angle of the plug-in port 105 can be optimized according to the relative position of the liquid drop falling point and the test paper sensing area. The plug-in port 105 is arranged obliquely, and the test paper is in a certain inclination state. This structure makes the liquid drop spread along the direction of the test paper surface after falling into the liquid receiving port 108, which helps to enhance the capillary guiding effect, shorten the penetration path of the reaction liquid on the test paper, and improve the liquid distribution uniformity.

[0043] In the embodiment, the pre-processing component is used to rotate the container 103 during the up-and-down movement of the container 103 to achieve sufficient mixing of the liquid in the container 103. Specifically, the pre-processing component includes a gear 200 connected to the container 103, and a rack 201 slidingly connected to the detection support 102. The gear 200 is arranged on the outer side surface of the container 103, and the rack 201 is arranged on the detection support 102 in the horizontal direction, and the rack 201 is engaged with the gear 200.

[0044] Through the above arrangement, when the detection support 102 moves up and down as a whole with the container 103, the rack 201 reciprocates transversely on the detection support 102, and the gear 200 is passively rotated due to the engagement between the rack 201 and the gear 200. The rotating motion directly acts on the container 103 body to make it rotate around its own axis to disturb, thereby achieving the stirring and mixing function of the liquid in the container 103. The rotating motion acts on the liquid in the container 103, which can disturb the liquid without damaging the sealing structure, so that the detection liquid in the container 103 and the original sample liquid complete physical mixing during vertical displacement.

[0045] At the same time, since the rotating action occurs synchronously with the movement of the container 103, the transition period of the container 103 from receiving liquid to releasing can be fully utilized to achieve sufficient mixing of the liquid under the natural transition rhythm, thereby providing higher uniformity and reaction stability for subsequent liquid release, and significantly improving the detection sensitivity and repeatability.

[0046] In the embodiment, the pre-processing component not only drives the container 103 to rotate and mix the liquid, but also includes a structure for heating the container 103. Specifically, the detection support 102 is provided with a mounting hole 202, and the outer wall of each container 103 is rotationally connected with the mounting hole 202 to achieve stable support in the rotating state.

[0047] The inner wall of the mounting hole 202 is provided with a heating cavity 203, and the heating cavity 203 is arranged along the inner periphery of the mounting hole 202, and an electric heating wire 204 is arranged inside. The electric heating wire 204 is used to provide a stable heat source for the container 103, and can heat the wall surface of the container 103 in the energized state, thereby achieving temperature control of the liquid in the container 103.

[0048] Through the above arrangement, during the operation of the detection device, when the container 103 moves up and down, the container 103 provided with the gear 200 is engaged with the rack 201 arranged on the detection support 102, and the rotating action is achieved through movement driving. At the same time, the outer wall of the container 103 is rotationally connected with the mounting hole 202 on the support to ensure the coaxial stability of the container 103 during rotation and maintain close contact with the heating cavity 203.

[0049] The inner wall of the installation port 202 is provided with a plurality of heating cavities 203 distributed in the circumferential direction. The heating cavities 203 are internally provided with electric heating wires 204. After being electrified, the electric heating wires 204 generate heat and conduct the heat to the wall surface of the container 103 in contact with the electric heating wires 204, so as to heat and treat the liquid in the container 103. The heating process can be adjusted in real time by the temperature control unit to adapt to different liquid reactions or inactivation requirements. In addition, by means of the rotating action of the container 103 in the heating process, the temperature gradient formed in the liquid due to static heating can be effectively broken, so that the liquid continuously performs heat convection exchange under the rotating disturbance, thereby realizing higher heating uniformity and heat reaction efficiency, and improving the stability and consistency of the sample processing process.

[0050] In the embodiment, in order to further optimize the dynamic response characteristics of the container 103 in the rotating process, the pretreatment component further includes two convex strips 205 arranged in the detection box 100.

[0051] The two ends of the rack 201 are rotationally connected with rollers 207, and each roller 207 is in surface contact with the convex strip 205 on the corresponding side. When the rack 201 moves up and down with the detection support 102, the rollers 207 roll on the arc-shaped protruding portions 206 of the convex strip 205, so as to guide the rack 201 to generate rhythmic transverse disturbance in the process of downward linear motion.

[0052] Through the above arrangement, when the detection support 102 moves up and down with the container 103 as a whole, the rollers 207 arranged at the two ends of the rack 201 slide on the two convex strips 205 in the detection box 100. Since the surface of the convex strip 205 is not smooth and straight, but is arranged with a plurality of arc-shaped protruding portions 206, the rollers 207 are affected by the arc-shaped protruding portions 206 in the sliding process, so as to enable the rack 201 to continuously move transversely on the predetermined path, thereby realizing the disturbance characteristics of the container 103 in the process of uniform rotation in the process of descending.

[0053] In the embodiment, in order to enhance the flow disturbance effect of the liquid in the container 103 in the rotating process, the inner wall of the container 103 is fixedly connected with a plurality of disturbance pieces 208. The disturbance pieces 208 can be strip-shaped structures protruding radially along the inner wall of the container 103. The plurality of disturbance pieces 208 are distributed in an equidistant staggered manner around the inner wall, and the width of the disturbance pieces 208 is less than the inner diameter of the container 103, which is constructed on the premise of not hindering the release of the liquid.

[0054] Through the above arrangement, in the process that the detection support 102 drives the container 103 to descend from the liquid receiving position to the detection plate 104, the pretreatment component starts to work, so that the container 103 is heated in the heating cavity 203 and simultaneously realizes the rotating disturbance through the structure of the gear 200 and the rack 201.

[0055] Due to the multiple disturbance pieces 208 arranged on the inner wall of the container 103, during rotation, the liquid not only generates flow around the shaft, but also forms complex shear flow, vortex and local disturbance under the repeated dispersion and segmentation of the disturbance pieces 208. This structure actively intervenes in the liquid flow pattern by physical means, which can effectively break the phenomena of liquid chromatography, suspension sedimentation or composition aggregation.

[0056] Especially in multi-component systems such as sample liquid, lysis liquid, buffer liquid, etc., different components have large differences in density and viscosity, which are prone to stratification. The disturbance piece 208 can strengthen the internal convection and boundary layer disturbance of the liquid, and improve the mixing uniformity.

[0057] In this embodiment, the detection component is arranged on each container 103, which includes a trigger tube 300 slidingly connected to the bottom of the container 103. An elastic structure, in this example a spring a 301, is arranged between the trigger tube 300 and the container 103, which is used to provide a reset force. A release tube a 303 is arranged inside the container 103, which is sleeved in the inner cavity of the trigger tube 300 from top to bottom, and maintains the relative position with the container 103 when the container 103 moves.

[0058] The inner cavity of the release tube a 303 constitutes a release cavity 304, which is used to temporarily store the liquid to be released. Two fluid passage structures are arranged on the release cavity 304: one is a liquid inlet passage 305, which is in communication with the main cavity of the container 103, and is used to receive the liquid stored in the container 103; the other is a liquid outlet passage 306, which is located corresponding to the blocking ring 302 on the inner wall of the trigger tube 300, and is controlled to be opened or closed in the sliding action.

[0059] Through the above arrangement, in the initial state, the spring a 301 is in the natural stretching state, and the trigger tube 300 is kept in the initial position under the action of the spring a 301. At this time, the liquid in the container 103 flows into the release cavity 304 through the liquid inlet passage 305, and the liquid outlet passage 306 is tightly closed by the blocking ring 302 on the inner wall of the trigger tube 300, so that the liquid is temporarily stored in the release cavity 304 and cannot flow out too early.

[0060] When the detection task starts, the moving part drives the detection support 102 and the container 103 to move downward, the trigger tube 300 at the bottom of the container 103 is inserted into the liquid receiving port 108 on the detection plate 104, and continues to press downward after contacting the detection plate 104. At this time, the trigger tube 300 is pushed in the vertical direction relative to the container 103 to slide upward, driving the spring a 301 to deform and compress. As the trigger tube 300 moves upward, the blocking ring 302 on the inner wall of the trigger tube 300 also moves upward synchronously, so as to gradually move away from the shielding position of the liquid outlet channel 306, and the liquid in the release cavity 304 can be smoothly discharged from the liquid outlet channel 306 and directly dropped onto the surface of the test paper through the trigger tube 300.

[0061] After the release is completed, the detection support 102 is temporarily moved upward, so that the trigger tube 300 is separated from the detection plate 104, and the trigger tube 300 falls back to the initial position under the restoring force of the spring a 301. At this time, the blocking ring 302 shields the liquid outlet channel 306 again, and the liquid inlet channel 305 is reopened, so that the release cavity 304 receives the liquid from the cavity of the container 103 again, to prepare for the next release.

[0062] The release cavity 304 provides a stable volume, avoids the influence of the liquid level of the container 103 on the release amount each time, ensures that the liquid amount of each test paper is consistent, and synchronizes the release action with the downward movement of the detection support 102. The blocking ring 302 is designed to close the liquid outlet channel 306 before release and automatically close after release, so that the whole operation is closed, avoiding aerosol or splashing pollution caused by manual drop, and cooperating with the liquid receiving port 108 and the detection plate 104 which can be inserted and extracted, the device is suitable for high-density array detection layout.

[0063] In the embodiment, the detection part further comprises a liquid inlet pipe 307 arranged at the top of the container 103, the liquid inlet pipe 307 is in sliding connection with the container 103 and is connected to the container 103 through an elastic member, and in this embodiment, the elastic member is a spring b 308 which is used to provide the upward restoring force of the liquid inlet pipe 307. The outer wall of the liquid inlet pipe 307 is provided with a liquid supplement channel 309, which is in a closed state in the initial state and is sleeved with the container 103.

[0064] The bottom of the liquid tank 101 is fixedly provided with a vertical downward release pipe b 310, and the outer wall of the release pipe b 310 is provided with a release port 313. The release port 313 is sleeved with a connecting ring 311, and the connecting ring 311 is elastically connected to the bottom of the liquid tank 101 through a spring c 312. In the natural state, the spring c 312 drives the connecting ring 311 to close the release port 313. The elastic potential energy of the spring c 312 is greater than that of the spring b 308, so as to ensure that the release port 313 is in a closed state before the container 103 is in place.

[0065] With the above arrangement, in the process of detecting the upward movement of the container 103 driven by the support 102, the liquid inlet pipe 307 at the top of the container 103 first interfaces with the release pipe b 310. As the movement process advances, the top end of the liquid inlet pipe 307 comes into contact with the connecting ring 311 and slides downward in the process of continuous upward movement, at which time the spring b 308 is compressed, the liquid inlet pipe 307 produces relative displacement, and the liquid supplement channel 309 on the outer wall thereof gradually enters the interior of the container 103 and forms communication.

[0066] As the liquid inlet pipe 307 further slides downward to the limit position thereof, the top of the liquid inlet pipe 307 continues to exert pressure on the connecting ring 311 and overcomes the elastic resistance of the spring c 312, so that the connecting ring 311 moves upward along the outer wall of the release pipe b 310 and leaves the release port 313 position. At this time, the liquid in the liquid tank 101 flows out from the interior of the release pipe b 310 under the action of gravity and is injected into the interior of the container 103 in turn through the release port 313, the liquid supplement channel 309 of the liquid inlet pipe 307, to complete the automatic injection of the liquid.

[0067] After the injection of liquid is completed, when the container 103 moves downward along the vertical direction with the detection support 102 to disengage from the bottom position of the liquid tank 101, the liquid inlet pipe 307 rebounds and resets upward under the action of the elastic force of the spring b 308, the liquid supplement channel 309 on the outer wall thereof is re-sheathed and shielded by the inner wall at the top of the container 103, so as to cut off the communication path between the liquid supplement channel 309 and the container 103, and further realize the automatic sealing of the opening at the top of the container 103. The structure ensures that the liquid in the container 103 will not leak or splash in the subsequent heating and rotation process. At the same time, the connecting ring 311 re-descends and covers the release port 313 under the action of the spring c 312, and the liquid release structure completes self-sealing, ready for the next injection of liquid.

[0068] In the embodiment, the detection component further comprises a connecting frame 400 fixedly arranged in the interior of the container 103, which is used for mounting and supporting the release pipe. The release pipe is rotatably connected to the connecting frame 400, and a spiral port 401 is formed in the outer wall thereof. The top of the trigger pipe 300 is provided with a guide rod 402 which is in sliding fit with the spiral port 401. When the trigger pipe 300 moves in the vertical direction, the guide rod 402 slides along the guide groove of the spiral port 401, so as to drive the release pipe to rotate.

[0069] The top of the release pipe a 303 is fixedly connected with a vertical rotating shaft 403 which is arranged along the axis of the container 103 and is provided with a plurality of radially distributed blade 404 structures. These blades 404 are used for disturbing the liquid in the container 103 in the mixing or heating stage, so as to realize the disturbance and homogeneous distribution of the liquid and improve the uniformity of treatment.

[0070] Through the above setting, in the device operation, the detection bracket 102 drives the container 103 to move downward, the trigger pipe 300 contacts the detection plate 104 and is forced to move upward relative to the container 103, at this time the guide rod 402 slides along the spiral port 401 of the outer wall of the release pipe, drives the release pipe to realize self-rotation in the vertical axis direction. The rotation not only triggers the action of the liquid release control structure, but also transmits the rotation to the blade 404 at the top of the release pipe through the rotating shaft 403, realizes the stirring of the blade 404 in the liquid. The blade 404 generates a turbulent flow to the liquid during rotation, effectively prevents the liquid from generating sedimentation or stratification phenomenon in the cavity, enhances the uniformity of the liquid composition, especially completes the mixing operation in a short time window before release.

[0071] After a liquid release and a corresponding test paper detection reaction are completed, the moving part drives the detection bracket 102 to perform a short upward movement, so that the container 103 as a whole leaves the current test paper slot position. The upward movement first makes the trigger pipe 300 at the bottom of the container 103 recover to the initial position under the elastic force of the spring a 301, and with the rebound of the trigger pipe 300, the guide rod 402 connected to the top thereof moves downward along the spiral port 401 under the action of the guide structure, drives the release pipe rotatingly connected to the container 103 to self-rotate again, so that the blade 404 at the top of the release pipe rotates.

[0072] At the same time, the short upward movement of the detection bracket 102 also provides necessary space for the operator to extract the detection plate 104 and replace the test paper, facilitates quick switching of the detection object. After the test paper replacement is completed, the detection bracket 102 moves downward again, the container 103 is positioned above the next group of test papers, and the subsequent release and detection process can be continued, forming an efficient, stable and automated multi-batch detection cycle.

[0073] Although the embodiments of the present application have been shown and described, it can be understood by those skilled in the art that various changes, modifications, replacements and variations can be made to the embodiments without departing from the principles and spirits of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. A contactless infectious disease pathogen detection apparatus, characterized by, The utility model relates to a detection device, including: a detection box (100) is provided with liquid tank (101) for storing detection liquid on the top of detection box (100); detection support (102) is arranged in detection box (100), and a plurality of containers (103) are arranged on detection support (102); detection board (104) is arranged on detection box (100), and detection board (104) is inserted in detection box (100) and is located below container (103), and detection box (100) is located above container (103), and a plurality of insertion interfaces (105) are formed in the side wall of detection board (104) and are used for inserting detection test paper; detection components are arranged on the container (103), which are used for receiving the liquid in the liquid tank (101) and releasing on the test paper surface of the detection board (104); a moving component is arranged between the detection box (100) and the detection support (102), which is used for moving the detection support (102) and the container (103) thereon up and down; a pretreatment component is arranged between the detection support (102) and the container (103), which is used for rotating and heating the container (103) when the container (103) moves up and down.

2. The non-contact infectious disease agent detection apparatus according to claim 1, wherein The moving component includes a lead screw (106) rotatably connected to the detection box (100), and a servo motor (107) is arranged on the detection box (100), and a driving shaft of the servo motor (107) is connected with the lead screw (106).

3. The non-contact infectious disease agent detection apparatus of claim 1, wherein, A liquid inlet (108) is formed in the top of test paper and communicates with the insertion interface (105), and the insertion interface (105) is arranged obliquely.

4. The non-contact infectious disease agent detection apparatus according to claim 1, wherein The pretreatment component includes a gear (200) connected to the container (103), and a rack (201) engaged with the gear (200) is slidably connected to the detection support (102).

5. The non-contact infectious disease agent detection apparatus of claim 1, wherein The pretreatment component further includes a mounting port (202) formed in the detection support (102), the container (103) is rotatably fitted in the mounting port (202), and a heating cavity (203) is formed in the inner wall of the mounting port (202), and an electric heating wire (204) is arranged in the heating cavity (203).

6. The non-contact infectious disease agent detection apparatus of claim 4, wherein, The pretreatment component further includes two convex strips (205) connected to the detection box (100), the convex strips (205) have a plurality of arc-shaped convex portions (206), and two sections of the rack (201) are rotatably connected with rollers (207) in contact with the convex strips (205).

7. The non-contact infectious disease agent detection apparatus of claim 1, wherein A plurality of disturbance pieces (208) are fixedly connected to the inner wall of the container (103).

8. The non-contact infectious disease agent detection apparatus of claim 1, wherein, When the container (103) moves upward to the position of the liquid tank (101), the liquid is received, and when the container (103) moves downward to the position of the detection board (104), the liquid is released, and the released liquid is a preset amount. The detection component comprises a trigger tube (300) slidably connected to the bottom of the container (103), a spring a (301) connected between the trigger tube (300) and the container (103), a retaining ring (302) arranged on the inner wall of the trigger tube (300), a release tube a (303) arranged in the container (103), a release cavity (304) formed in the release tube a (303), a liquid inlet channel (305) and a liquid outlet channel (306) formed on the release cavity (304), the liquid inlet channel (305) being communicated with the container (103), and the liquid outlet channel (306) corresponding to the position of the retaining ring (302).

9. The non-contact infectious disease agent detection apparatus of claim 1, wherein, The detection component further comprises a liquid inlet tube (307) slidably connected to the top of the container (103), a spring b (308) connected between the liquid inlet tube (307) and the container (103), a liquid supplement channel (309) formed on the outer wall of the liquid inlet tube (307), a release tube b (310) communicated with the bottom of the liquid tank (101), a connecting ring (311) slidably sleeved on the outer wall of the release tube b (310), a spring c (312) connected between the connecting ring (311) and the liquid tank (101), and a release port (313) formed on the outer wall of the release tube b (310) corresponding to the connecting ring (311).

10. The non-contact infectious disease agent detection apparatus of claim 8, wherein, After the container (103) receives the liquid, multiple batches of test papers can be released multiple times, and the liquid is mixed once before and after each release; The detection component further comprises a connecting frame (400) fixed in the container (103), the release tube a (303) is rotationally connected to the connecting frame (400), a spiral port (401) is formed on the outer wall of the release tube a (303), a guide rod (402) matched with the spiral port (401) is connected to the top of the trigger tube (300), a rotating shaft (403) is connected to the top of the release tube a (303), and a plurality of blades (404) are arranged on the rotating shaft (403).

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