Preparation method and application of titanium dental implant surface coating

Abstract

The invention belongs to the technical field of biomedical engineering, and particularly relates to a preparation method and application of a titanium dental implant surface coating, and the preparation method comprises the following steps: S1, pretreatment of a titanium dental implant matrix: sequentially carrying out grinding and polishing, ultrasonic cleaning and acid etching treatment; s2, preparation of a coating precursor solution: adding nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles into deionized water, stirring to form a suspension, then adding a silver nitrate solution, and continuously stirring to form the coating precursor solution; s3, coating a coating: coating the surface of the pretreated titanium dental implant matrix with the coating precursor solution by adopting an electrophoretic deposition method; and S4, drying and sintering: drying and sintering the coated titanium dental implant. According to the preparation method of the titanium dental implant surface coating, provided by the invention, the bonding strength between the coating and the titanium dental implant matrix can be improved.

Description

Technical Field

[0001] This invention belongs to the field of biomedical engineering technology, specifically a method for preparing and applying a coating on the surface of a titanium dental implant. Background Technology

[0002] In the field of oral medicine, titanium and titanium alloys have become the preferred materials for dental implants due to their excellent biocompatibility, mechanical properties, and corrosion resistance. However, the bioactivity of pure titanium implant surfaces is relatively low, and the strength and speed of integration with bone tissue need to be improved. This may lead to problems such as insufficient initial implant stability and excessively long osseointegration time, affecting the success rate of implantation and the patient's recovery process. To address the aforementioned issues, various surface modification technologies have been developed, among which surface coating technology is an effective approach. By preparing bioactive coatings on the surface of titanium dental implants, the adhesion, proliferation, and differentiation of osteoblasts can be promoted, accelerating the osseointegration process. Currently, commonly used surface coating materials for titanium dental implants include calcium phosphate bioceramics such as hydroxyapatite and tricalcium phosphate, as well as some bioactive polymers. However, existing methods for preparing surface coatings for titanium dental implants have some drawbacks, such as low bonding strength between the coating and the substrate, making them prone to detachment, thus affecting the long-term stability and lifespan of the implant. Summary of the Invention

[0003] The purpose of this invention is to provide a method for preparing and applying a coating on the surface of titanium dental implants, which can improve the bonding strength between the coating and the substrate.

[0004] To achieve the above objectives, the technical solution adopted by the present invention is: to provide a method for preparing a surface coating of a titanium dental implant, comprising the following steps: S1. Pretreatment of titanium dental implant matrix: grinding and polishing, ultrasonic cleaning and acid etching are performed in sequence; S2. Preparation of coating precursor solution: Nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles are added to deionized water and stirred to form a suspension. Then, silver nitrate solution is added and stirring is continued to form coating precursor solution. S3. Coating application: The coating precursor solution is coated onto the surface of the pretreated titanium dental implant substrate using an electrophoretic deposition method; S4. Drying and sintering: The coated titanium dental implants are dried and sintered.

[0005] Optionally, in step S1, the grinding and polishing is performed using silicon carbide sandpaper with grit sizes of 180 mesh, 400 mesh, 800 mesh and 1200 mesh, until the roughness of the titanium dental implant substrate surface reaches 0.1-0.3 μm.

[0006] Optionally, in step S1, ultrasonic cleaning involves sequentially immersing the polished titanium dental implant matrix in acetone, anhydrous ethanol, and deionized water for 15-20 minutes each time, at a temperature of 25-30°C.

[0007] Optionally, in step S1, the acid etching process involves immersing the ultrasonically cleaned titanium dental implant substrate in an acid etching solution at a temperature of 30-40°C for 10-15 minutes. The acid etching solution is a mixture of hydrofluoric acid and nitric acid in a mass ratio of 1:1, and the concentrations of both hydrofluoric acid and nitric acid are 5-8 mol / L.

[0008] Optionally, in step S2, the mass ratio of nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles is (5-8):(2-3):1:(1-2), the particle size of the nano-hydroxyapatite powder is 50-100nm, and the particle size of the titanium dioxide nanoparticles is 20-50nm.

[0009] Optionally, in step S2, during the formation of the suspension, the solution is heated to 60-70°C, and the stirring speed is 300-500 r / min for 2-3 hours; after the silver nitrate solution is added, stirring continues for 30-60 minutes.

[0010] Optionally, the parameters for electrophoretic deposition in step S3 are: voltage 10-20V, deposition time 10-20 minutes, electrode spacing 2-3cm, and deposition temperature room temperature.

[0011] Optionally, in step S4, the drying temperature is 60-80℃ and the drying time is 2-4 hours; sintering is carried out under inert gas protection, with a heating rate of 5-10℃ / min, a sintering temperature of 500-600℃, and a holding time of 2-3 hours.

[0012] The titanium dental implants prepared using the above-described method for preparing the surface coating of titanium dental implants are used in oral dental implantation.

[0013] Compared with the prior art, the present invention has the following beneficial effects: (1) The preparation method of the titanium dental implant surface coating provided by the present invention improves the roughness and activity of the substrate surface by pre-treating the titanium dental implant substrate, including grinding and polishing, ultrasonic cleaning and acid etching, which is beneficial to the bonding between the coating and the substrate. At the same time, the addition of titanium dioxide nanoparticles can enhance the cohesion of the coating. Furthermore, the use of electrophoretic deposition method and reasonable sintering process during coating further improves the bonding strength between the coating and the substrate, thereby preventing the coating from falling off.

[0014] (2) The preparation method of the surface coating of titanium dental implant provided by the present invention adds nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles to the coating. Among them, the composition of nano-hydroxyapatite is similar to the inorganic components in human bone tissue, and it has good bioactivity, which can promote the adhesion, proliferation and differentiation of osteoblasts; titanium dioxide nanoparticles have good biocompatibility and photocatalytic activity, which can further promote bone integration. At the same time, titanium dioxide nanoparticles have excellent corrosion resistance, and adding them to the coating can improve the corrosion resistance of the coating, thereby extending the service life of the titanium dental implant; in addition, chitosan and gelatin have biocompatibility and degradability, which can provide a good microenvironment for cell growth and further improve the bioactivity of the coating.

[0015] (3) The preparation method of the titanium dental implant surface coating provided by the present invention introduces silver ions into the coating. Silver ions have broad-spectrum antibacterial properties and can effectively inhibit the growth and reproduction of bacteria in the oral cavity. Titanium dioxide nanoparticles can generate free radicals under light irradiation and have a certain antibacterial effect. Together with silver ions, they further improve the antibacterial effect of the coating, reduce the occurrence of peri-implant inflammation, and improve the implantation success rate. Detailed Implementation

[0016] Example 1 Titanium dental implant matrix pretreatment (1) Grinding and polishing: Use silicon carbide sandpaper with grit sizes of 180 mesh, 400 mesh, 800 mesh and 1200 mesh to grind the surface of the titanium dental implant until the surface roughness Ra reaches 0.1 μm.

[0017] (2) Ultrasonic cleaning: The polished titanium dental implant matrix is ​​placed in acetone, anhydrous ethanol and deionized water for ultrasonic cleaning in sequence. Each cleaning time is 15 minutes and the cleaning temperature is 25℃. (3) Acid etching treatment: The ultrasonically cleaned titanium dental implant substrate is placed in the acid etching solution and soaked at 30°C for 10 minutes. The acid etching solution is a mixture of hydrofluoric acid and nitric acid in a volume ratio of 1:1, and the concentration of each is 5 mol / L. After acid etching treatment, it is rinsed with deionized water and dried with nitrogen gas to obtain the pretreated titanium dental implant substrate. Preparation of coating precursor solution (1) Add nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles to deionized water, wherein the particle size of nano-hydroxyapatite powder is 50 nm, the particle size of titanium dioxide nanoparticles is 20 nm, and the mass ratio of nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles is 5:2:1:1. (2) Under the condition of stirring speed of 300r / min, the above mixed solution is heated to 60°C and stirred continuously for 2 hours until a uniform suspension is formed. (3) Add a silver nitrate solution with a concentration of 0.5 mol / L to the suspension. The mass ratio of nano hydroxyapatite powder to silver nitrate is 10:1. Continue stirring for 30 minutes to obtain the coating precursor solution. Coating application The coating precursor solution was coated onto the pretreated titanium dental implant substrate surface using an electrophoretic deposition method. The specific parameters were: voltage 10V, deposition time 10 minutes, electrode spacing 2cm, and deposition temperature room temperature. Drying and sintering (1) Place the coated titanium dental implant into a vacuum drying oven and dry it at 60°C for 2 hours.

[0018] (2) The dried titanium dental implant is placed in a sintering furnace and heated to 500°C at a rate of 5°C / min under inert gas protection. It is held for 2 hours and then naturally cooled to room temperature to obtain a titanium dental implant with a surface coating. Example 2 Titanium dental implant matrix pretreatment (1) Grinding and polishing: Use silicon carbide sandpaper with grit sizes of 180 mesh, 400 mesh, 800 mesh and 1200 mesh to grind the surface of the titanium dental implant until the surface roughness Ra reaches 0.2 μm.

[0019] (2) Ultrasonic cleaning: The polished titanium dental implant matrix is ​​placed in acetone, anhydrous ethanol and deionized water for ultrasonic cleaning in sequence. Each cleaning time is 18 minutes and the cleaning temperature is 28℃. (3) Acid etching treatment: The ultrasonically cleaned titanium dental implant substrate is placed in the acid etching solution and soaked at 35°C for 12 minutes. The acid etching solution is a mixture of hydrofluoric acid and nitric acid with a volume ratio of 1:1 and a concentration of 6 mol / L. After acid etching treatment, it is rinsed with deionized water and dried with nitrogen gas to obtain the pretreated titanium dental implant substrate. Preparation of coating precursor solution (1) Add nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles to deionized water, wherein the particle size of nano-hydroxyapatite powder is 80 nm, the particle size of titanium dioxide nanoparticles is 35 nm, and the mass ratio of nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles is 6:2.5:1:1.5. (2) Under the condition of stirring speed of 400 r / min, the above mixed solution is heated to 65°C and stirred continuously for 2.5 hours until a uniform suspension is formed. (3) Add silver nitrate solution with a concentration of 0.8 mol / L to the suspension. The mass ratio of nano hydroxyapatite powder to silver nitrate is 10:1.5. Continue stirring for 45 minutes to obtain the coating precursor solution. Coating application The coating precursor solution was coated onto the pretreated titanium dental implant substrate surface using an electrophoretic deposition method. The specific parameters were: voltage 15V, deposition time 15 minutes, electrode spacing 2.5cm, and deposition temperature room temperature. Drying and sintering (1) Place the coated titanium dental implant in a vacuum drying oven and dry it at 70°C for 3 hours.

[0020] (2) The dried titanium dental implant is placed in a sintering furnace and heated to 550°C at a heating rate of 8°C / min under inert gas protection. It is held for 2.5 hours and then naturally cooled to room temperature to obtain a titanium dental implant with a surface coating. Example 3 Titanium dental implant matrix pretreatment (1) Grinding and polishing: Use silicon carbide sandpaper with grit sizes of 180 mesh, 400 mesh, 800 mesh and 1200 mesh to grind the surface of the titanium dental implant until the surface roughness Ra reaches 0.3 μm.

[0021] (2) Ultrasonic cleaning: The polished titanium dental implant matrix is ​​placed in acetone, anhydrous ethanol and deionized water for ultrasonic cleaning in sequence. Each cleaning time is 20 minutes and the cleaning temperature is 30℃. (3) Acid etching treatment: The ultrasonically cleaned titanium dental implant substrate is placed in the acid etching solution and soaked at 40°C for 15 minutes. The acid etching solution is a mixture of hydrofluoric acid and nitric acid with a volume ratio of 1:1 and a concentration of 8 mol / L. After acid etching treatment, it is rinsed with deionized water and dried with nitrogen gas to obtain the pretreated titanium dental implant substrate. Preparation of coating precursor solution (1) Add nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles to deionized water, wherein the particle size of nano-hydroxyapatite powder is 100nm, the particle size of titanium dioxide nanoparticles is 50nm, and the mass ratio of nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles is 8:3:1:2. (2) Under the condition of stirring speed of 500 r / min, the above mixed solution is heated to 70°C and stirred continuously for 3 hours until a uniform suspension is formed. (3) Add a silver nitrate solution with a concentration of 1 mol / L to the suspension. The mass ratio of nano hydroxyapatite powder to silver nitrate is 10:2. Continue stirring for 60 minutes to obtain the coating precursor solution. Coating application The coating precursor solution was coated onto the pretreated titanium dental implant substrate surface using an electrophoretic deposition method. The specific parameters were: voltage 20V, deposition time 20 minutes, electrode spacing 3cm, and deposition temperature room temperature. Drying and sintering (1) Place the coated titanium dental implant into a vacuum drying oven and dry it at 80°C for 4 hours.

[0022] (2) The dried titanium dental implant is placed in a sintering furnace and heated to 600°C at a rate of 10°C / min under inert gas protection. It is held for 3 hours and then naturally cooled to room temperature to obtain a titanium dental implant with a surface coating. Comparative Example 1 Compared with Example 2, the acid etching step is omitted, while the other steps and parameters are the same. Comparative Example 2 Compared with Example 2, no silver nitrate solution was added to the coating precursor solution, but all other steps and parameters were the same. Comparative Example 3 Compared with Example 2, no titanium dioxide nanoparticles were added to the coating precursor solution, while all other steps and parameters were the same.

[0023] Coating adhesion strength test Experimental Methods: The scratch test method was used to test the bonding strength of the surface coatings of the titanium dental implants prepared in Examples 1-3 and Comparative Examples 1-3 using a scratch tester. Test parameters: loading rate 10 N / min, scratch length 5 mm, diamond indenter radius 200 μm. The critical load at which the coating peeled off was recorded, which is the bonding strength between the coating and the substrate.

[0024] Table 1 shows the relevant experimental data for coating adhesion strength testing.

[0025] Table 1

[0026] As shown in Table 1, the coating bonding strength of Examples 1 to 3 is significantly higher than that of Comparative Examples 1 to 3. Comparative Example 1 omits acid etching, resulting in lower substrate surface roughness and bonding strength; Comparative Example 2 does not add silver nitrate, affecting the interfacial bonding between the coating and the substrate; Comparative Example 3 does not add titanium dioxide nanoparticles, resulting in insufficient coating cohesion and lower bonding strength than the examples; Example 2 exhibits the highest bonding strength and has the optimal process parameters.

[0027] Bioactivity test Experimental Methods: A simulated body fluid (SBF) immersion test was conducted. Titanium dental implant samples prepared in Examples 1 to 3 and Comparative Examples 1 to 3 were immersed in SBF at 37°C. After 7 and 14 days, the samples were removed and the hydroxyapatite deposition on the sample surface was observed using a scanning electron microscope (SEM). The phase composition of the deposition layer was analyzed using X-ray diffraction (XRD). Experimental data: After 7 days, hydroxyapatite particles were clearly deposited on the surface of the samples in Examples 1 to 3, and a continuous coating was formed after 14 days; the sample in Comparative Example 1 had only a small amount of particles after 7 days, and the deposition amount was small and discontinuous after 14 days; the sample in Comparative Example 2 had a certain amount of particles after 7 days, and the deposition amount after 14 days was more than that in Comparative Example 1, but less than that in Examples 1 to 3; the deposition amount of the sample in Comparative Example 3 was less than that in Example 2 after 7 days, and the continuity of the hydroxyapatite coating deposited after 14 days was not as good as that in Example 2. XRD analysis showed that the material deposited on the surface of the samples in Examples 1 to 3 and Comparative Examples 2 and 3 was mainly hydroxyapatite, while the characteristic peaks of hydroxyapatite on the surface of the sample in Comparative Example 1 were weaker. In summary, Examples 1 to 3, containing nano-hydroxyapatite, titanium dioxide, and other components, exhibit high bioactivity, with the photocatalytic activity of titanium dioxide nanoparticles promoting hydroxyapatite deposition; Comparative Example 3, lacking titanium dioxide, shows decreased bioactivity; Example 2 demonstrates the best bioactivity.

[0028] Antibacterial performance test Experimental Methods: The inhibition zone test was used. Staphylococcus aureus and Escherichia coli, common oral pathogens, were selected as test strains. The titanium dental implant samples prepared in Examples 1 to 3 and Comparative Examples 1 to 3 were placed on agar plates containing bacterial solution and incubated at 37°C for 24 hours. The diameter of the inhibition zone was then measured.

[0029] Table 2 shows the relevant experimental data for antibacterial performance testing.

[0030] Table 2

[0031] Table 2 shows that Comparative Example 2, lacking silver nitrate, had no antibacterial effect; Examples 1 to 3, containing silver ions and titanium dioxide, exhibited synergistic antibacterial activity and a large inhibitory ring; Comparative Example 3, lacking titanium dioxide, had a weaker antibacterial effect than the Examples; the coating in Comparative Example 1 was prone to peeling off, indicating poor antibacterial effect. Example 2 showed the best antibacterial effect.

[0032] Corrosion resistance test Experimental Methods: Electrodynamic polarization curves were performed using an electrochemical workstation to evaluate the corrosion resistance of the surface coatings of titanium dental implants prepared in Examples 1-3 and Comparative Examples 1-3. Tests were conducted in artificial saliva at 37°C using a three-electrode system: the sample was the working electrode, a saturated calomel electrode was the reference electrode, and a platinum sheet was the auxiliary electrode. The scan rate was 1 mV / s, and the scan range was -1.0 V to 1.0 V (relative to the reference electrode). The corrosion current density and corrosion potential were calculated from the polarization curves. A lower corrosion current density and a higher corrosion potential indicated better corrosion resistance of the coating.

[0033] Table 3 shows the relevant experimental data for corrosion resistance testing.

[0034] Table 3

[0035] According to the data in Table 3, the corrosion current density of Examples 1 to 3 is significantly lower than that of Comparative Examples 1 to 3, and the corrosion potential is higher than that of Comparative Examples 1 to 3, indicating that the corrosion resistance of Examples 1 to 3 is significantly better than that of the comparative examples. Comparative Example 1, due to the omission of acid etching treatment, has a weak coating bond, making it prone to damage in corrosive environments, leading to an increased corrosion current density and decreased corrosion resistance. Comparative Example 2, without silver nitrate, has some impact on corrosion resistance, but the impact is less than that of Comparative Examples 1 and 3. Comparative Example 3 did not add titanium dioxide nanoparticles, and since titanium dioxide has excellent corrosion resistance, its absence reduces the corrosion resistance of the coating, resulting in a higher corrosion current density and lower corrosion potential than Examples 1 to 3. Example 2 has the lowest corrosion current density, the highest corrosion potential, and the best corrosion resistance, which is attributed to its reasonable process parameters and the synergistic effect of each component. The titanium dioxide nanoparticles are uniformly distributed in the coating, effectively blocking the intrusion of corrosive media.

[0036] Osteointegration Performance Test Experimental Methods: Eighteen healthy adult Beagle dogs were randomly divided into 6 groups of 3 dogs each. Titanium dental implants prepared according to Examples 1-3 and Comparative Examples 1-3 were implanted into the bilateral mandibles of each dog, one implanted on each side. The dogs were sacrificed at 4, 8, and 12 weeks post-operation, and bone tissue specimens containing the implants were collected. Pathological sections were prepared using histological techniques, and the bone integration rate was calculated through histological observation. The microhardness of the bone tissue surrounding the implants was measured using a microhardness tester.

[0037] Bone integration rate (%) = (Total linear length of implant surface in direct contact with bone tissue ÷ Total linear length of implant exposed in tissue sections) × 100% Table 4 shows the relevant experimental data for osseointegration performance testing.

[0038] Table 4

[0039] As shown in Table 4, the bone integration rate of each group gradually increased over time. Examples 1-3 showed significantly higher bone integration rates and bone microhardness at each time point than Comparative Examples 1-3. Example 2 demonstrated the best performance, with a bone integration rate of 55% at four weeks and 95% at 12 weeks, and a bone microhardness of 280 HV. Comparative Example 1 suffered from poor coating adhesion, affecting bone integration. Comparative Example 2 lacked silver nitrate, potentially leading to mild inflammation that hindered bone integration. Comparative Example 3 lacked titanium dioxide, resulting in decreased bioactivity and corrosion resistance, and its bone integration effect was inferior to the examples. This indicates that the coatings of Examples 1-3 can promote the formation of high-quality bone tissue, especially the synergistic effect of Example 2, which is more conducive to bone integration.

[0040] The present invention provides a method for preparing a surface coating for titanium dental implants. Pretreatment improves the properties of the substrate surface by adding titanium dioxide nanoparticles to the coating precursor solution, which synergistically interact with other components. Experimental results show that the coating prepared by this method exhibits high bonding strength (35-45 MPa), good bioactivity, excellent antibacterial properties, and strong corrosion resistance, accelerating osseointegration. Example 2 demonstrates the best performance. In contrast, the performance of comparative examples lacking acid etching treatment, silver nitrate, or titanium dioxide all decreased. The surface coating preparation method for titanium dental implants provided by this invention is simple and controllable, and the prepared titanium dental implants show broad application prospects in the field of dental implantology.

[0041] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A method for preparing a surface coating for titanium dental implants, characterized in that, Includes the following steps: S1. Pretreatment of titanium dental implant matrix: grinding and polishing, ultrasonic cleaning and acid etching are performed in sequence; S2. Preparation of coating precursor solution: Nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles are added to deionized water and stirred to form a suspension. Then, silver nitrate solution is added and stirring is continued to form coating precursor solution. S3. Coating application: The coating precursor solution is coated onto the surface of the pretreated titanium dental implant substrate using an electrophoretic deposition method; S4. Drying and sintering: The coated titanium dental implants are dried and sintered.

2. The method for preparing a surface coating for a titanium dental implant as described in claim 1, characterized in that: In step S1, grinding and polishing are performed using silicon carbide sandpaper with grit sizes of 180 mesh, 400 mesh, 800 mesh and 1200 mesh, until the surface roughness of the titanium dental implant matrix reaches 0.1-0.3μm.

3. The method for preparing a surface coating for a titanium dental implant as described in claim 1, characterized in that: In step S1, ultrasonic cleaning involves immersing the polished titanium dental implant substrate in acetone, anhydrous ethanol, and deionized water in sequence. Each cleaning session lasts 15-20 minutes, and the cleaning temperature is 25-30℃.

4. The method for preparing a surface coating for a titanium dental implant as described in claim 1, characterized in that: In step S1, the acid etching process involves immersing the ultrasonically cleaned titanium dental implant substrate in an acid etching solution at a temperature of 30-40°C for 10-15 minutes. The acid etching solution is a mixture of hydrofluoric acid and nitric acid in a mass ratio of 1:1, and the concentrations of both hydrofluoric acid and nitric acid are 5-8 mol / L.

5. The method for preparing a surface coating for a titanium dental implant as described in claim 1, characterized in that: In step S2, the mass ratio of nano-hydroxyapatite powder, chitosan, gelatin and titanium dioxide nanoparticles is (5-8):(2-3):1:(1-2), the particle size of the nano-hydroxyapatite powder is 50-100nm, and the particle size of the titanium dioxide nanoparticles is 20-50nm.

6. The method for preparing a surface coating for a titanium dental implant as described in claim 1, characterized in that: In step S2, during the formation of the suspension, the solution is heated to 60-70°C and stirred at a speed of 300-500 r / min for 2-3 hours; after the silver nitrate solution is added, stirring continues for 30-60 minutes.

7. The method for preparing a surface coating for a titanium dental implant as described in claim 1, characterized in that: The parameters for electrophoretic deposition in step S3 are: voltage 10-20V, deposition time 10-20 minutes, electrode spacing 2-3cm, and deposition temperature room temperature.

8. The method for preparing a surface coating for a titanium dental implant as described in claim 1, characterized in that: In step S4, the drying temperature is 60-80℃ and the drying time is 2-4 hours; sintering is carried out under inert gas protection, with a heating rate of 5-10℃ / min, a sintering temperature of 500-600℃, and a holding time of 2-3 hours.

9. A titanium dental implant prepared by the method for preparing the surface coating of a titanium dental implant according to any one of claims 1-8, and applied to dental implantation.

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