Normal-temperature rapid oxygen consumption device for medical and chemical analysis and use method of normal-temperature rapid oxygen consumption device

By using a pluggable, high-efficiency catalytic oxygen-consuming module and a standardized, fast-coupling interface, the problem of catalyst activity degradation requiring professional maintenance in existing devices has been solved. This enables rapid catalyst replacement and leak-free connection, improving the accuracy and detection efficiency of medical chemical analysis.

CN120919937APending Publication Date: 2025-11-11SHENZHEN SECOND PEOPLES HOSPITAL (SHENZHEN INST OF TRANSLATIONAL MEDICINE)
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Patent Information

Application Number
CN202511111819.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-08
Publication Date
2025-11-11

AI Technical Summary

Technical Problem

In existing medical chemical analysis devices, the oxygen consumption function is implemented in a fixed integrated manner, which leads to the need for professional personnel to disassemble and maintain the device after the catalyst activity decreases. Moreover, it cannot be replaced quickly, which poses a risk of contamination and results in low flexibility and maintenance efficiency.

Method used

It adopts a pluggable high-efficiency catalytic oxygen-consuming module, combined with a standardized fast coupling interface and precise closed-loop airflow control, to achieve rapid catalyst replacement and leak-free connection. It consumes oxygen by loading a highly active room-temperature catalyst with a high specific surface area material.

Benefits of technology

It enables rapid catalyst replacement and leak-free connection, avoids contact contamination between the catalyst and the reaction system, improves the accuracy of analytical results and detection efficiency, and reduces maintenance costs.

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Abstract

The invention provides a normal-temperature rapid oxygen consumption device for medical chemical analysis and a use method, and is characterized in that the normal-temperature rapid oxygen consumption device is composed of a device host, a main control unit, a gas circulation / driving unit, an analysis reaction unit and a pluggable efficient catalytic oxygen consumption module. The oxygen consumption speed far higher than that of a traditional method is achieved at normal temperature, the design effectively avoids chemical reagent interference and damage of high temperature to biological samples, and instant and pure low-oxygen environment guarantee is provided for oxygen-sensitive medical chemical analysis such as glucose oxidase reaction and chemiluminescence detection. And the accuracy and reliability of an analysis result are remarkably improved.
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Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a room-temperature rapid oxygen-consuming device for medical chemical analysis and its usage method. Background Technology

[0002] A room-temperature rapid oxygen depletion device is a tool used in medical chemical analysis. It rapidly consumes oxygen at room temperature by using a highly efficient catalyst (such as activated copper powder) to induce an oxidation reaction between dissolved oxygen and reducing substances in the sample. Its main purpose is to eliminate the interference of oxygen in certain sensitive chemical analyses (such as glucose and uric acid determination), improving the accuracy and stability of detection. It is widely used in clinical testing and biochemical analysis.

[0003] In existing medical chemical analysis devices, oxygen consumption functions are often implemented in a fixed integrated manner (such as a built-in non-replaceable catalyst layer or a complex sealed reaction chamber). This results in the need for professional personnel to disassemble and maintain the device after the catalyst activity declines, leading to long downtime. It is also impossible to quickly replace the dedicated oxygen-consuming core according to the oxygen consumption requirements of different tests. Furthermore, the catalyst or oxygen scavenger is directly exposed near the reaction system, posing a risk of contaminating sensitive samples or reagents, thus limiting flexibility, maintenance efficiency, and safety. Summary of the Invention

[0004] Technical problems to be solved To address the shortcomings of existing technologies, this invention provides a room-temperature rapid oxygen-consuming device and its usage method for medical chemical analysis. This solves the problem that in existing medical chemical analysis devices, the oxygen-consuming function is often implemented in a fixed integrated manner, which leads to the need for professional personnel to disassemble and maintain the device after the catalyst activity decreases.

[0005] Technical solution To achieve the above objectives, the present invention is implemented through the following technical solution: a room temperature rapid oxygen consumption device for medical chemical analysis, characterized in that it consists of a device host, a main control unit, a gas circulation / drive unit, an analysis reaction unit, and a pluggable high-efficiency catalytic oxygen consumption module; The pluggable high-efficiency catalytic oxygen-consuming module includes: Module housing: provides physical support and encapsulation; High-efficiency room-temperature catalyst support structure: Encapsulated in a shell, it consists of a highly active room-temperature catalyst supported on a high specific surface area material; Optimized airflow channels: Designed within the shell, surrounding the catalyst support structure, to maximize the contact efficiency between the gas and the catalyst and the reaction rate; Standardized quick-coupled interface: Located at one end of the module housing, it is used to achieve quick and reliable connection and sealing between the module and the host interface socket, and specifically includes: (1) Positioning structure: Ensures that the module is inserted in the only correct direction; (2) Main sealing ring: provides sealing for the main airflow channel between the module and the host interface face; (3) Fluid port: recessed or flush design, serving as a channel for gas to enter and exit the module; (4) Port sealing rings: provide a secondary seal for each fluid port connection to prevent leakage; Locking mechanism: Works in conjunction with the locking mechanism on the host side to reliably secure the module.

[0006] Preferably, the gas circulation / drive unit includes a miniature air pump, a flow sensor, and a control valve. The miniature air pump is used to drive the flow of the gas to be treated; the flow sensor is used to monitor the gas flow rate; and the control valve is used to adjust the airflow path and flow rate.

[0007] Preferably, the analytical reaction unit consists of a sample reaction chamber, a reaction channel of a microfluidic chip, and a detection chamber of a biosensor.

[0008] Preferably, the main control unit includes a microprocessor and a control circuit, used to receive flow sensor signals, control the speed of the micro air pump, control valve switching, and optionally read the identity information or status signal of the pluggable high-efficiency catalytic oxygen-consuming module.

[0009] Preferably, the main unit of the device is provided with an oxygen-consuming module interface socket, which includes a positioning structure that precisely corresponds to the standardized quick coupling interface of the module, a precision sealing end face, a protruding fluid pin / sleeve, a locking mechanism, and an electrical connection socket / sensor.

[0010] The method of using a room-temperature rapid oxygen-consuming device for medical chemical analysis is characterized by the following steps: S1. Based on the analysis requirements, select a suitable pluggable high-efficiency catalytic oxygen-consuming module, align the standardized quick coupling interface of the module with the oxygen-consuming module interface seat of the main unit, push the module in a straight line to the mechanical stop, and perform a locking operation to compress the main sealing ring and port sealing ring on the module housing to form a leak-free seal. At the same time, the inlet / outlet of the module is connected to the fluid pin / sleeve of the main unit. S2. Start the main control unit and turn on the device power. The main control unit initializes the gas circulation / drive unit and connects the gas inlet and outlet of the medical chemical analysis component to be protected to the gas circuit of the device: the gas outlet of the analysis reaction unit is connected to the gas inlet of the gas circulation / drive unit; the purified gas output of the device is connected to the protective gas inlet of the analysis reaction unit. S3. Start Gas Circulation: The main control unit starts the micro gas pump to drive gas out of the analysis and reaction unit; the control valve switches to the oxygen consumption path, and the gas flows through: the analysis and reaction unit, the gas circulation / drive unit, and the oxygen consumption module inlet. After entering the module, the gas flows through the optimized airflow channel. At room temperature (20–30℃), the oxygen in the gas comes into full contact with the high-efficiency room temperature catalyst carrier structure, and a rapid catalytic reaction occurs, realizing oxygen consumption. The flow sensor monitors the flow rate in real time and feeds it back to the main control unit. The main control unit dynamically adjusts the speed of the micro gas pump and the valve opening to ensure that the gas flows through the catalyst at the optimal flow rate. Then, the target gas flow rate and running time are set by the main control unit. S4. Delivery of purified gas: The low-oxygen / oxygen-free flow after oxygen consumption is output from the module outlet, through the interface seat fluid sleeve → device purified gas output end → analysis reaction unit protection gas inlet, continuously replacing the oxygen in the reaction chamber, and performing oxygen-sensitive operation in the low-oxygen environment maintained by the module. S5. Status monitoring: The main control unit records the cumulative usage time / flow of the module; monitors catalytic activity in real time and triggers a "replacement reminder" alarm.

[0011] Beneficial effects This invention provides a room-temperature rapid oxygen-consuming device for medical chemical analysis and its usage method. It has the following beneficial effects: This invention achieves an oxygen consumption rate far exceeding that of traditional methods at room temperature through a pluggable, high-efficiency catalytic oxygen-consuming module and precise closed-loop airflow control. This design effectively avoids interference from chemical reagents and damage to biological samples caused by high temperatures, providing an immediate and pure low-oxygen environment for oxygen-sensitive medical chemical analyses such as glucose oxidase reactions and chemiluminescence detection, significantly improving the accuracy and reliability of analytical results.

[0012] The unique standardized quick-coupled interface design allows for rapid plug-and-play replacement of the core oxygen-consuming module. Users can complete maintenance within seconds without tools or professional training. The modular packaging isolates the catalyst from the reaction system, effectively preventing cross-contamination, and supports the selection of different performance modules as needed. This significantly simplifies the operation process, reduces maintenance costs, and ensures the continuity and efficiency of high-throughput medical testing. Attached Figure Description

[0013] Figure 1 This is a flowchart of the room-temperature rapid oxygen consumption device for medical chemical analysis and its usage method proposed in this invention. Detailed Implementation

[0014] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0015] Example: like Figure 1 As shown, this embodiment of the invention provides a room-temperature rapid oxygen consumption device for medical chemical analysis, characterized in that it consists of a device host, a main control unit, a gas circulation / drive unit, an analysis reaction unit, and a pluggable high-efficiency catalytic oxygen consumption module; The pluggable high-efficiency catalytic oxygen depletion module includes: Module housing: provides physical support and encapsulation; High-efficiency room-temperature catalyst support structure: Encapsulated in a shell, it consists of a highly active room-temperature catalyst supported on a high specific surface area material; Optimized airflow channels: Designed within the shell, surrounding the catalyst support structure, to maximize the contact efficiency between the gas and the catalyst and the reaction rate; Standardized quick-coupled interface: Located at one end of the module housing, it is used to achieve quick and reliable connection and sealing between the module and the host interface socket, and specifically includes: (1) Positioning structure: Ensures that the module is inserted in the only correct direction; (2) Main sealing ring: provides sealing for the main airflow channel between the module and the host interface face; (3) Fluid port: recessed or flush design, serving as a channel for gas to enter and exit the module; (4) Port sealing rings: provide a secondary seal for each fluid port connection to prevent leakage; Locking mechanism: In conjunction with the locking mechanism on the host side, the module is reliably fixed. The pluggable high-efficiency catalytic oxygen-consuming module is physically connected, sealed and locked to the oxygen-consuming module interface seat on the host device through its standardized quick coupling interface. The module's air inlet is connected to the air outlet of the gas circulation / drive unit through the fluid pin / sleeve of the interface seat; the module's air outlet is connected to the air inlet / protective gas inlet of the analysis reaction unit through another fluid pin / sleeve of the interface seat.

[0016] The gas circulation / drive unit includes a micro gas pump, a flow sensor, and control valves. The micro gas pump drives the flow of the gas to be treated; the flow sensor monitors the gas flow rate; and the control valves regulate the airflow path and flow rate. The micro gas pump in the gas circulation / drive unit pumps the gas to be treated (usually a carrier gas drawn from the analysis reaction unit or directly introduced). Under the command of the main control unit, the control valves guide the gas flow through the inlet of the pluggable high-efficiency catalytic oxygen-consuming module, the optimized airflow channel, the high-efficiency room-temperature catalyst support structure, and the outlet. During this process, the oxygen in the gas is rapidly catalyzed and consumed by the catalyst at room temperature.

[0017] The analytical reaction unit consists of a sample reaction chamber, a reaction channel of a microfluidic chip, and a detection chamber of a biosensor. The flow sensor monitors the gas flow rate through the module in real time and feeds the signal back to the main control unit. The main control unit dynamically adjusts the speed of the micro gas pump and the opening of the control valve according to the preset program or analytical requirements to optimize the airflow state (flow rate, flow rate) and ensure the most efficient oxygen consumption rate.

[0018] The main control unit includes a microprocessor and control circuitry, used to receive flow sensor signals, control the speed of the micro air pump, control valve switching, and optionally read the identity information or status signal of the pluggable high-efficiency catalytic oxygen-consuming module. The low-oxygen / oxygen-free flow processed by the module is accurately delivered back to or introduced into the analysis reaction unit through the module's outlet and the fluid pin / sleeve of the interface seat, providing a protective environment for oxygen-sensitive reactions (such as enzyme reactions, specific chemiluminescence detection, and cell culture observation).

[0019] The main unit of the device is equipped with an oxygen-consuming module interface socket, which includes a positioning structure that precisely corresponds to the standardized quick-coupling interface of the module, a precision sealing end face, a raised fluid pin / sleeve, a locking mechanism, and an electrical connection socket / sensor. The main control unit reads the identity information (model, batch, lifespan) of the inserted pluggable high-efficiency catalytic oxygen-consuming module or receives the signal from its built-in status indicator sensor through the electrical connection socket / sensor of the oxygen-consuming module interface socket, for module effectiveness monitoring, usage counting, and replacement prompts.

[0020] The method of using a room-temperature rapid oxygen-consuming device for medical chemical analysis is characterized by the following steps: S1. Based on the analysis requirements, select a suitable pluggable high-efficiency catalytic oxygen-consuming module, align the standardized quick coupling interface of the module with the oxygen-consuming module interface seat of the main unit, push the module in a straight line to the mechanical stop, and perform a locking operation to compress the main sealing ring and port sealing ring on the module housing to form a leak-free seal. At the same time, the inlet / outlet of the module is connected to the fluid pin / sleeve of the main unit. S2. Start the main control unit and turn on the device power. The main control unit initializes the gas circulation / drive unit and connects the gas inlet and outlet of the medical chemical analysis component to be protected to the gas circuit of the device: the gas outlet of the analysis reaction unit is connected to the gas inlet of the gas circulation / drive unit; the purified gas output of the device is connected to the protective gas inlet of the analysis reaction unit. S3. Start Gas Circulation: The main control unit starts the micro gas pump, driving gas to be drawn out from the analysis and reaction unit; the control valve switches to the oxygen-consuming path, and the gas flows through: the analysis and reaction unit, the gas circulation / drive unit, and the oxygen-consuming module inlet. After entering the module, the gas flows through the optimized airflow channel; at room temperature (20–30℃), the oxygen in the gas comes into full contact with the high-efficiency room-temperature catalyst support structure, resulting in a rapid catalytic reaction. To achieve oxygen consumption, a flow sensor monitors the flow rate in real time and feeds it back to the main control unit. The main control unit dynamically adjusts the speed of the micro gas pump and the valve opening to ensure that the gas flows through the catalyst at the optimal flow rate. Then, the target gas flow rate and running time are set through the main control unit. S4. Delivery of purified gas: The low-oxygen / oxygen-free flow after oxygen consumption is output from the module outlet, through the interface seat fluid sleeve → device purified gas output end → analysis reaction unit protection gas inlet, continuously replacing the oxygen in the reaction chamber, and performing oxygen-sensitive operation in the low-oxygen environment maintained by the module. S5. Status monitoring: The main control unit records the cumulative usage time / flow of the module; monitors catalytic activity in real time and triggers a "replacement reminder" alarm.

[0021] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A room-temperature rapid oxygen-consuming device for medical chemical analysis, characterized in that, It consists of a main unit, a main control unit, a gas circulation / drive unit, an analysis and reaction unit, and a pluggable high-efficiency catalytic oxygen-consuming module; The pluggable high-efficiency catalytic oxygen-consuming module includes: Module housing: provides physical support and encapsulation; High-efficiency room-temperature catalyst support structure: Encapsulated in a shell, it consists of a highly active room-temperature catalyst supported on a high specific surface area material; Optimized airflow channels: Designed within the shell, surrounding the catalyst support structure, to maximize the contact efficiency between the gas and the catalyst and the reaction rate; Standardized quick-coupled interface: Located at one end of the module housing, it is used to achieve quick and reliable connection and sealing between the module and the host interface socket, and specifically includes: (1) Positioning structure: Ensures that the module is inserted in the only correct direction; (2) Main sealing ring: provides sealing for the main airflow channel between the module and the host interface face; (3) Fluid port: recessed or flush design, serving as a channel for gas to enter and exit the module; (4) Port sealing rings: provide a secondary seal for each fluid port connection to prevent leakage; Locking mechanism: Works in conjunction with the locking mechanism on the host side to reliably secure the module.

2. The room-temperature rapid oxygen consumption device for medical chemical analysis according to claim 1, characterized in that: The gas circulation / drive unit includes a miniature air pump, a flow sensor, and a control valve. The miniature air pump is used to drive the flow of the gas to be processed; the flow sensor is used to monitor the gas flow rate; and the control valve is used to adjust the airflow path and flow rate.

3. The room-temperature rapid oxygen consumption device for medical chemical analysis according to claim 1, characterized in that: The analytical reaction unit consists of a sample reaction chamber, a reaction channel of a microfluidic chip, and a detection chamber of a biosensor.

4. The room-temperature rapid oxygen consumption device for medical chemical analysis according to claim 1, characterized in that: The main control unit includes a microprocessor and control circuitry, used to receive flow sensor signals, control the speed of the micro air pump, control valve switching, and optionally read the identity information or status signals of the pluggable high-efficiency catalytic oxygen-consuming module.

5. The room-temperature rapid oxygen consumption device for medical chemical analysis according to claim 1, characterized in that: The main unit of the device is equipped with an oxygen-consuming module interface socket, which includes a positioning structure that precisely corresponds to the standardized quick coupling interface of the module, a precision sealing end face, a protruding fluid pin / sleeve, a locking mechanism, and an electrical connection socket / sensor.

6. A method for using a room-temperature rapid oxygen-consuming device for medical chemical analysis, characterized in that, The following usage steps are included: S1. Based on the analysis requirements, select a suitable pluggable high-efficiency catalytic oxygen-consuming module, align the standardized quick coupling interface of the module with the oxygen-consuming module interface seat of the main unit, push the module in a straight line to the mechanical stop, and perform a locking operation to compress the main sealing ring and port sealing ring on the module housing to form a leak-free seal. At the same time, the inlet / outlet of the module is connected to the fluid pin / sleeve of the main unit. S2. Start the main control unit and turn on the device power. The main control unit initializes the gas circulation / drive unit and connects the gas inlet and outlet of the medical chemical analysis component to be protected to the gas circuit of the device: the gas outlet of the analysis reaction unit is connected to the gas inlet of the gas circulation / drive unit; the purified gas output of the device is connected to the protective gas inlet of the analysis reaction unit. S3. Start Gas Circulation: The main control unit starts the micro gas pump to drive gas out of the analysis and reaction unit; the control valve switches to the oxygen consumption path, and the gas flows through: the analysis and reaction unit, the gas circulation / drive unit, and the oxygen consumption module inlet. After entering the module, the gas flows through the optimized airflow channel. At room temperature (20–30℃), the oxygen in the gas comes into full contact with the high-efficiency room temperature catalyst carrier structure, and a rapid catalytic reaction occurs, realizing oxygen consumption. The flow sensor monitors the flow rate in real time and feeds it back to the main control unit. The main control unit dynamically adjusts the speed of the micro gas pump and the valve opening to ensure that the gas flows through the catalyst at the optimal flow rate. Then, the target gas flow rate and running time are set by the main control unit. S4. Delivery of purified gas: The low-oxygen / oxygen-free flow after oxygen consumption is output from the module outlet, through the interface seat fluid sleeve → device purified gas output end → analysis reaction unit protection gas inlet, continuously replacing the oxygen in the reaction chamber, and performing oxygen-sensitive operation in the low-oxygen environment maintained by the module. S5. Status monitoring: The main control unit records the cumulative usage time / flow of the module; monitors catalytic activity in real time and triggers a "replacement reminder" alarm.