Polymer sodium hyaluronate composition and preparation method thereof

Abstract

The invention relates to a high-molecular sodium hyaluronate composition and a preparation method thereof. The wound dressing is prepared from sodium hyaluronate, carbomer, hydroxyethyl cellulose, glycerol, phenoxyethanol and triethanolamine, is used for wound dressing, and plays a physical barrier role by forming a protective layer on the surface of a wound. The wound dressing is used for nursing non-chronic wounds such as small wounds, scratches and cutting wounds and surrounding skin. The polymer sodium hyaluronate composition forms a thin wet film on the surface of a wound surface, provides a wet environment for the wound surface, and is isolated from the external environment, so that the moisturizing and isolating effects are achieved, a good repairing environment is formed for the wound surface, and wound surface rehabilitation is accelerated. The contained components cannot be absorbed by a human body and are safe to use.

Description

Technical Field

[0001] This invention relates to the field of medical composition technology, specifically to a high molecular weight sodium hyaluronate composition and its preparation method. Background Technology

[0002] Currently, the scientific community generally believes that sodium hyaluronate is beneficial for wound healing when used in medical dressings. Sodium hyaluronate is a stable disaccharide derivative formed by the linkage of N-acetyl-D-glucosamine and β-D-glucuronic acid through β-1,3-glycosidic bonds. These disaccharide units repeat continuously, forming the long-chain structure of hyaluronic acid; its large molecular weight allows it to form a transparent hydration film on the skin surface, providing a moist healing environment for the wound and thus promoting healing.

[0003] With the current popularity of cosmetic procedures, skin is often more sensitive and fragile afterward. Using medical-grade skincare products can quickly cool the skin, provide a moisturized environment, create a protective barrier, and accelerate wound healing. However, because these products come into direct contact with damaged skin, they must be sterile and safe. Existing products have complex ingredients and numerous functions, making them unsuitable for sensitive skin, skin damaged after cosmetic procedures (laser, IPL), chemical peels (glycolic acid peels), or sunburn. Conversely, skin affected by exogenous allergies, cosmetic procedures (laser, IPL), chemical peels (glycolic acid peels), or sunburn urgently needs a moist microenvironment for cooling, repair, and care. Summary of the Invention

[0004] In view of the problems existing in the prior art, the present invention discloses a high molecular weight sodium hyaluronate composition, the main components and their weight ratios as follows: Sodium hyaluronate 0.2%-0.5%; Glycerin 3%-5%; Hydroxyethyl cellulose 0.2%-0.4%; Triethanolamine 0.05%-0.2%; Phenoxyethanol 0.1%; Carbomer 0.05%-0.2%; the balance is purified water.

[0005] A method for preparing a high molecular weight sodium hyaluronate composition includes the following steps: Step 1: Select triethanolamine by weight and mix it with 9 times its weight of purified water to prepare a triethanolamine solution. Step 2: Select carbomer by weight and soak it in purified water for 12-24 hours. Take it out and put it into an emulsification pot and add an appropriate amount of purified water. Use a homogenizer to stir at 40 r / min for 10 minutes to mix evenly so that the solution is uniformly light white and free of flocculent precipitate, thus obtaining the carbomer solution. Step 3: Select hydroxyethyl cellulose and an appropriate amount of purified water by weight and put them into an aqueous phase pot. Heat with steam and stir continuously for no less than 0.5 hours. Mix evenly until the solution is a uniform and transparent liquid without flocculent precipitate to obtain hydroxyethyl cellulose solution. Step 4: Select sodium hyaluronate and glycerin by weight ratio, mix and stir evenly, then add an appropriate amount of purified water into the aqueous phase pot, heat with steam and stir constantly for no less than 0.5 hours, mix evenly so that the solution is a uniform and transparent liquid without flocculent precipitate, and obtain sodium hyaluronate solution. Step 5: Place the obtained carbomer solution and hydroxyethyl cellulose solution into an emulsifying pot, stir at room temperature until they are evenly mixed, then add sodium hyaluronate solution and phenoxyethanol selected according to the weight ratio, mix evenly, add triethanolamine solution to adjust the pH value of the mixed solution to between 5.0 and 7.5, stir with a stirrer at a speed of 20-40 r / min for 0.5 hours to make the solution evenly mixed without layering, and obtain a high molecular weight sodium hyaluronate composition.

[0006] As a preferred embodiment of the present invention, the steam heating temperature in step three does not exceed 80°C, and the stirring speed is 40 r / min.

[0007] As a preferred embodiment of the present invention, the steam heating temperature in step four does not exceed 50°C, and the stirring speed is 40 r / min.

[0008] The beneficial effects of this invention: This invention uses sodium hyaluronate, carbomer, hydroxyethyl cellulose, glycerin, phenoxyethanol, and triethanolamine to form a wound dressing. It acts as a physical barrier by forming a protective layer on the wound surface. It is used for the care of small wounds, abrasions, cuts, and other non-chronic wounds and surrounding skin. The high-molecular-weight sodium hyaluronate composition forms a thin, moist film on the wound surface, providing a moist environment while isolating it from the external environment, thus achieving moisturizing and isolating effects. This creates a favorable repair environment for the wound and accelerates wound healing. The ingredients are not absorbed by the human body, making it safe to use. Detailed Implementation

[0009] Example 1

[0010] The present invention discloses a high molecular weight sodium hyaluronate composition, the main components and their weight ratios being: sodium hyaluronate 0.2%, glycerol 3%, hydroxyethyl cellulose 0.2%, triethanolamine 0.05%, phenoxyethanol 0.1%, carbomer 0.05%, and purified water 96.4%.

[0011] A method for preparing a high molecular weight sodium hyaluronate composition includes the following steps: Step 1: Select triethanolamine by weight and mix it with 9 times its weight of purified water to prepare a triethanolamine solution. Step 2: Select carbomer by weight and soak it in purified water for 12 hours. Take it out and put it into an emulsification pot and add an appropriate amount of purified water. Use a homogenizer to stir at 40 r / min for 10 minutes to mix evenly so that the solution is uniformly light white and free of flocculent precipitate, thus obtaining the carbomer solution. Step 3: Select hydroxyethyl cellulose and an appropriate amount of purified water by weight and put them into an aqueous phase pot. Heat with steam and stir continuously. The steam heating temperature should not exceed 80℃, the stirring speed should be 40r / min, and the stirring time should not be less than 0.5 hours. Mix evenly so that the solution is a uniform and transparent liquid without flocculent precipitate to obtain hydroxyethyl cellulose solution. Step 4: Select sodium hyaluronate and glycerin by weight ratio, mix and stir evenly, then add an appropriate amount of purified water into the aqueous phase pot, heat with steam and stir constantly. The steam heating temperature should not exceed 50℃, the stirring speed should be 40r / min, and the stirring time should not be less than 0.5 hours. Mix evenly so that the solution is a uniform and transparent liquid without flocculent precipitate, and obtain sodium hyaluronate solution. Step 5: Place the obtained carbomer solution and hydroxyethyl cellulose solution into an emulsifying pot, stir at room temperature until they are evenly mixed, then add sodium hyaluronate solution and phenoxyethanol selected according to the weight ratio, mix evenly, add triethanolamine solution to adjust the pH value of the mixed solution to between 5.0 and 7.5, stir with a stirrer at 20 r / min for 0.5 hours to make the solution evenly mixed without layering, and obtain a high molecular weight sodium hyaluronate composition.

[0012] Example 2

[0013] The present invention discloses a high molecular weight sodium hyaluronate composition, the main components and their weight ratios being: sodium hyaluronate 0.5%, glycerol 5%, hydroxyethyl cellulose 0.4%, triethanolamine 0.2%, phenoxyethanol 0.1%, carbomer 0.2%, and purified water 93.6%.

[0014] A method for preparing a high molecular weight sodium hyaluronate composition includes the following steps: Step 1: Select triethanolamine by weight and mix it with 9 times its weight of purified water to prepare a triethanolamine solution. Step 2: Select carbomer by weight and soak it in purified water for 24 hours. Take it out and put it into an emulsification pot and add an appropriate amount of purified water. Use a homogenizer to stir at 40 r / min for 10 minutes to mix evenly so that the solution is uniformly light white and free of flocculent precipitate, thus obtaining the carbomer solution. Step 3: Select hydroxyethyl cellulose and an appropriate amount of purified water by weight and put them into an aqueous phase pot. Heat with steam and stir continuously. The steam heating temperature should not exceed 80℃, the stirring speed should be 40r / min, and the stirring time should not be less than 0.5 hours. Mix evenly so that the solution is a uniform and transparent liquid without flocculent precipitate to obtain hydroxyethyl cellulose solution. Step 4: Select sodium hyaluronate and glycerin by weight ratio, mix and stir evenly, then add an appropriate amount of purified water into the aqueous phase pot, heat with steam and stir constantly. The steam heating temperature should not exceed 50℃, the stirring speed should be 40r / min, and the stirring time should not be less than 0.5 hours. Mix evenly so that the solution is a uniform and transparent liquid without flocculent precipitate, and obtain sodium hyaluronate solution. Step 5: Place the obtained carbomer solution and hydroxyethyl cellulose solution into an emulsifying pot, stir at room temperature until they are evenly mixed, then add sodium hyaluronate solution and phenoxyethanol selected according to the weight ratio, mix evenly, add triethanolamine solution to adjust the pH value of the mixed solution to between 5.0 and 7.5, stir with a stirrer at 40 r / min for 0.5 hours to make the solution evenly mixed without layering, and obtain a high molecular weight sodium hyaluronate composition.

[0015] Example 3

[0016] The present invention discloses a high molecular weight sodium hyaluronate composition, the main components and their weight ratios being: sodium hyaluronate 0.35%, glycerol 4%, hydroxyethyl cellulose 0.3%, triethanolamine 0.15%, phenoxyethanol 0.1%, carbomer 0.15%, and purified water 94.95%.

[0017] A method for preparing a high molecular weight sodium hyaluronate composition includes the following steps: Step 1: Select triethanolamine by weight and mix it with 9 times its weight of purified water to prepare a triethanolamine solution. Step 2: Select carbomer by weight and soak it in purified water for 18 hours. Take it out and put it into an emulsification pot and add an appropriate amount of purified water. Use a homogenizer to stir at 40 r / min for 10 minutes to mix evenly so that the solution is uniformly light white and free of flocculent precipitate, thus obtaining the carbomer solution. Step 3: Select hydroxyethyl cellulose and an appropriate amount of purified water by weight and put them into an aqueous phase pot. Heat with steam and stir continuously. The steam heating temperature should not exceed 80℃, the stirring speed should be 40r / min, and the stirring time should not be less than 0.5 hours. Mix evenly so that the solution is a uniform and transparent liquid without flocculent precipitate to obtain hydroxyethyl cellulose solution. Step 4: Select sodium hyaluronate and glycerin by weight ratio, mix and stir evenly, then add an appropriate amount of purified water into the aqueous phase pot, heat with steam and stir constantly. The steam heating temperature should not exceed 50℃, the stirring speed should be 40r / min, and the stirring time should not be less than 0.5 hours. Mix evenly so that the solution is a uniform and transparent liquid without flocculent precipitate, and obtain sodium hyaluronate solution. Step 5: Place the obtained carbomer solution and hydroxyethyl cellulose solution into an emulsifying pot, stir at room temperature until they are evenly mixed, then add sodium hyaluronate solution and phenoxyethanol selected according to the weight ratio, mix evenly, add triethanolamine solution to adjust the pH value of the mixed solution to between 5.0 and 7.5, stir with a stirrer at 30 r / min for 0.5 hours to make the solution evenly mixed without layering, and obtain a high molecular weight sodium hyaluronate composition.

[0018] Components not described in detail in this article are existing technologies.

[0019] While the specific embodiments of the present invention have been described in detail above, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention, and modifications or variations without creative effort are still within the protection scope of the present invention.

Claims

1. A high molecular weight sodium hyaluronate composition, characterized in that, Its main components and weight ratios are as follows: sodium hyaluronate 0.2%-0.5%, glycerin 3%-5%, hydroxyethyl cellulose 0.2%-0.4%, triethanolamine 0.05%-0.2%, phenoxyethanol 0.1%, carbomer 0.05%-0.2%, and the balance being purified water.

2. The high molecular weight sodium hyaluronate composition according to claim 1, characterized in that: It includes 0.35% sodium hyaluronate, 4% glycerin, 0.3% hydroxyethyl cellulose, 0.15% triethanolamine, 0.1% phenoxyethanol, 0.15% carbomer, and 94.95% purified water.

3. The method for preparing a high molecular weight sodium hyaluronate composition according to claim 1, characterized in that, The steps include the following: Step 1: Select triethanolamine by weight and mix it with 9 times its weight of purified water to prepare a triethanolamine solution. Step 2: Select carbomer by weight and soak it in purified water for 12-24 hours. Take it out and put it into an emulsification pot and add an appropriate amount of purified water. Use a homogenizer to stir at 40 r / min for 10 minutes to mix evenly so that the solution is uniformly light white and free of flocculent precipitate, thus obtaining the carbomer solution. Step 3: Select hydroxyethyl cellulose and an appropriate amount of purified water by weight and put them into an aqueous phase pot. Heat with steam and stir continuously for no less than 0.5 hours. Mix evenly until the solution is a uniform and transparent liquid without flocculent precipitate to obtain hydroxyethyl cellulose solution. Step 4: Select sodium hyaluronate and glycerin by weight ratio, mix and stir evenly, then add an appropriate amount of purified water into the aqueous phase pot, heat with steam and stir constantly for no less than 0.5 hours, mix evenly so that the solution is a uniform and transparent liquid without flocculent precipitate, and obtain sodium hyaluronate solution. Step 5: Place the obtained carbomer solution and hydroxyethyl cellulose solution into an emulsifying pot, stir at room temperature until they are evenly mixed, then add sodium hyaluronate solution and phenoxyethanol selected according to the weight ratio, mix evenly, add triethanolamine solution to adjust the pH value of the mixed solution to between 5.0 and 7.5, and stir with a stirrer at a speed of 20-40 r / min for 0.5 hours to make the solution evenly mixed without layering, thus obtaining a high molecular weight sodium hyaluronate composition.

4. The method for preparing a high molecular weight sodium hyaluronate composition according to claim 3, characterized in that: In step three, the steam heating temperature should not exceed 80°C, and the stirring speed should be 40 r / min.

5. The method for preparing a high molecular weight sodium hyaluronate composition according to claim 3, characterized in that: In step four, the steam heating temperature shall not exceed 50°C, and the stirring speed shall be 40 r / min.