Mixing device for medical intermediate processing

Abstract

The invention relates to the technical field of medicine preparation devices, and discloses a mixing device for medical intermediate processing, which comprises a workbench, a mixing device, a solid raw material feeding device, a material elevator, a solution pump station and a console, the mixing device is arranged on the inner side of the workbench; the solid raw material feeding device is arranged at the top of the stirring and mixing mechanism; the material elevator is arranged on the left front portion of the workbench. The solution pump station is arranged on the front side of the workbench; the control table is installed on the top of the workbench, and the material hoister and the solution pump station are electrically connected with the control table. An automatic material feeding and solution filling mode is adopted, manual intervention is reduced, operation errors are reduced, materials are fed from the interior of liquid in the reaction kettle, the materials are rapidly mixed with the reaction liquid through the stirrer while feeding is conducted, the reaction efficiency is improved, and accumulation of the materials on the surface of the liquid level is reduced.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical preparation equipment technology, specifically to a mixing device for processing pharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates are core raw materials in the pharmaceutical industry, and the mixing process in their preparation directly determines the purity, reaction conversion rate, and the quality stability of subsequent drugs. In the industrial production of pharmaceutical intermediates (such as those prepared by reacting sodium sulfite with phosphoric acid solution), mixing equipment must meet three core requirements: precise feeding, efficient mixing, and stable temperature control. However, current mixing equipment on the market generally suffers from the following technical deficiencies: 1. High risk of error and contamination due to excessive manual intervention: Solid raw materials are handled and dumped manually, and liquid raw materials require manual monitoring of flow rate. This is labor-intensive, inefficient, and the randomness of manual operation can easily lead to imbalance in raw material ratio. In addition, manual contact with raw materials can easily cause cross-contamination, which does not meet GMP requirements. 2. Poor feeding method, local concentration is easy to be too high: solid raw materials are directly fed above the liquid surface, which makes them easy to accumulate and agglomerate, unable to disperse quickly, prolonging the reaction time, and may also cause side reactions and reduce the purity of intermediates; 3. The stirring mode is simple and the mixing efficiency is low: most of them are single continuous rotation stirring, which can only achieve the overall circulation of liquid, making it difficult to fully disturb different areas. Some areas have dead zones, and uneven mixing affects the reaction conversion rate. 4. Poor quantitative conveying and large proportioning error: Solid raw materials mostly use a single conveying channel, making it difficult to flexibly adjust the flow rate and without real-time weighing feedback, making it difficult to accurately control the total amount of material fed. These defects restrict the production efficiency and quality stability of pharmaceutical intermediates. Therefore, a mixing device with functions such as "automated feeding, internal dispersion, efficient mixing, precise temperature control, and quantitative delivery" is needed to solve the pain points of existing technologies. Summary of the Invention

[0003] The purpose of this invention is to provide a mixing apparatus for processing pharmaceutical intermediates, so as to solve the problems mentioned in the background art.

[0004] To achieve the above objectives, the present invention provides the following technical solution: a mixing device for processing pharmaceutical intermediates, comprising: a workbench, a mixing device, a solid raw material feeding device, a material elevator, a solution pump station, and a control console; the mixing device is disposed on the inner side of the workbench; the solid raw material feeding device is disposed on the top of the mixing mechanism; the material elevator is disposed on the left front of the workbench; the solution pump station is disposed on the front side of the workbench; the control console is installed on the top of the workbench, and the material elevator and the solution pump station are electrically connected to the control console.

[0005] Preferably, the mixing device includes: a base, a mixing device body, a temperature control device, a top cover, a first motor, and a stirring and mixing mechanism; the base is disposed on the inner bottom of the workbench; the mixing device body is mounted on the top of the base, and the liquid inlet of the mixing device body is connected to a solution pump station via a pipe; the temperature control device is disposed on the inner side of the base, and the temperature control device and the mixing device body are connected via a pipe, and the temperature control device and the control console are electrically connected; the top cover is mounted on the top of the inner cavity of the mixing device body; the first motor is mounted on the top right side of the top of the top cover, the rotating end of the first motor extends out of the lower surface of the top cover, and the first motor and the control console are electrically connected; the stirring and mixing mechanism is disposed on the top of the inner cavity of the mixing device body.

[0006] Preferably, the mixing mechanism includes: a truss, a grooved wheel, a first electromagnetic clutch, a transmission belt assembly, a first mounting base, a drive wheel, a cam, and a second electromagnetic clutch; the truss is arranged at the top of the inner cavity of the mixing device body in the front-rear direction; the grooved wheel is rotatably connected to the middle of the truss via a bearing; one end of the first electromagnetic clutch is connected to the top of the shaft of the grooved wheel, and the first electromagnetic clutch is electrically connected to the control console; one end of the transmission belt assembly is mounted on the bottom of the rotating end of the first motor, and the other end of the transmission belt assembly is connected to the other end of the first electromagnetic clutch; the first mounting base is mounted on the bottom right side of the top cover; the drive wheel is rotatably connected to the bottom left side of the first mounting base via a rotating shaft, and the shaft of the drive wheel extends into the inner side of the first mounting base; the cam is mounted on the right end of the shaft of the drive wheel; the second electromagnetic clutch is mounted on the bottom right side of the inner side of the first mounting base, one end of the second electromagnetic clutch is connected to the right end of the shaft of the cam, and the second electromagnetic clutch is electrically connected to the control console.

[0007] Preferably, the mixing mechanism further includes: a second motor, a bevel gear assembly, a second mounting base, a U-shaped connecting rod, a first drive rod, and a rotating rod; the second motor is mounted on the top right end of the top cover, the rotating end of the second motor extends to the lower surface of the top cover, and the second motor is electrically connected to the control console; one end of the bevel gear assembly is mounted on the bottom of the rotating end of the second motor, and the other end of the bevel gear assembly is mounted on the outer side of the other end of the second electromagnetic clutch; the second mounting base is located on the front side of the middle of the bottom end of the top cover; the U-shaped connecting rod is rotatably connected to the inner bottom end of the second mounting base through a bearing, and the left and right sides of the shaft of the U-shaped connecting rod extend out of the outside of the second mounting base; the first drive rod is mounted on the right end of the shaft of the U-shaped connecting rod, and the rear side of the bottom end of the first drive rod contacts the outside of the cam; the rotating rod is mounted on the left end of the shaft of the U-shaped connecting rod.

[0008] Preferably, the mixing mechanism further includes: a third mounting base, a first connecting rod, a spring connecting rod, a connecting pin, a stirring rod, and a feeding component; the third mounting base is installed vertically on the lower left front of the bottom end of the top cover; one end of the first connecting rod is rotatably connected to the lower left side of the third mounting base via a rotating shaft; one end of the spring connecting rod is connected to the outer front end of the rotating rod via a rotating shaft, and the inner side of the other end of the spring connecting rod is connected to the outer side of the first connecting rod via a rotating shaft; the connecting pin is installed on the left side of the other end of the first connecting rod; the stirring rod is installed at the bottom end of the shaft of the grooved wheel; and the feeding component is installed on the left side of the bottom end of the top cover.

[0009] Preferably, the feeding component includes: a housing, insertion holes, a feeding port, insertion rods, a chute frame, a connecting frame, and a storage unit; the housing is installed vertically at the left opening of the top cover; there are two insertion holes, which are respectively located at the front and rear ends of the bottom right side of the housing; the feeding port is located at the top of the inner cavity of the housing; there are two insertion rods, which are respectively inserted into the bottom of the inner cavities of the front and rear insertion holes; the chute frame is installed at the bottom ends of the front and rear insertion rods, and the connecting pin is inserted into the inner cavity of the chute frame; the connecting frame is installed on the left side of the chute frame; and the storage unit is located inside the connecting frame.

[0010] Preferably, the storage unit includes: a storage cylinder, a mesh cover, a first sealing cover, a second sealing cover, a third connecting rod, a micro motor, a second drive rod, and a second connecting rod; the storage cylinder is installed inside the connecting frame in a vertical direction, and the top end of the storage cylinder extends into the inner cavity of the outer shell; the mesh cover is detachably installed at the bottom end of the inner cavity of the storage cylinder; the first sealing cover is rotatably connected to the bottom left side of the outer wall of the storage cylinder via a rotating shaft; the second sealing cover is rotatably connected to the outside of the first sealing cover via a rotating shaft and is located at the bottom right side of the outer wall of the storage cylinder; there are two third connecting rods, one end of which is respectively installed at the front end of the shaft core of the first and second sealing covers; there are two micro motors, which are installed at the bottom ends of the left and right sides of the outer wall of the storage cylinder, and the micro motors are electrically connected to the control console; there are two second drive rods, one end of which is respectively installed at the front side of the rotating end of the two micro motors; there are two second connecting rods, one end of which is respectively connected to the other end of the two second drive rods via a rotating shaft, and the other end of which is respectively connected to the other end of the two third connecting rods via a rotating shaft.

[0011] Preferably, the solid raw material feeding device includes: a base frame, a first mounting platform, a first conveying cylinder, a second conveying cylinder, and a cover shell; the base frame is installed vertically on the top left side of the workbench; the first mounting platform is fixedly installed on the top of the base frame; the first conveying cylinder is installed horizontally on the top rear side of the first mounting platform via a bracket; the second conveying cylinder is installed horizontally on the top front side of the first mounting platform via a bracket, and the inner diameter of the second conveying cylinder is smaller than the inner diameter of the first conveying cylinder; the cover shell is installed on the left side of the first mounting platform.

[0012] Preferably, the solid raw material feeding device further includes: a third motor, a first spiral conveyor, a fourth motor, a second spiral conveyor, a first hopper, a vibrating feeder, and a connecting pipe; the third motor is located on the rear side of the inner cavity of the outer shell, the rotating end of the third motor extends into the inner cavity of the first conveying cylinder, and the third motor is electrically connected to the control console; the first spiral conveyor is installed in the left-right direction at the rotating end of the third motor and located in the inner cavity of the first conveying cylinder; the fourth motor is located on the front side of the inner cavity of the outer shell, the rotating end of the fourth motor extends into the inner cavity of the second conveying cylinder, and the fourth motor is electrically connected to the control console; the second spiral conveyor is installed in the left-right direction at the rotating end of the fourth motor and located in the inner cavity of the second conveying cylinder; the first hopper is installed above the inlets of the first and second conveying cylinders; the vibrating feeder is installed at the top of the inner cavity of the first hopper, and the vibrating feeder is electrically connected to the control console; one end of the connecting pipe is connected to the inlet of the vibrating feeder, and the other end of the connecting pipe is connected to the outlet of the material elevator.

[0013] Preferably, the solid raw material feeding device further includes: a second mounting platform, a slot housing, a sealing plate, an electric telescopic rod, a second hopper, a storage housing, and a weighing sensor; the second mounting platform is installed outside the base frame and below the first mounting platform; the slot housing is installed on the top right side of the second mounting platform; the sealing plate is inserted into the inner cavity of the slot housing; there are two electric telescopic rods, which are respectively installed at the front and rear ends of the top left side of the second mounting platform, and the telescopic ends of the two electric telescopic rods are connected to the front and rear ends of the left side of the sealing plate, and the electric telescopic rods are electrically connected to the control console; the second hopper is installed inside the right opening of the second mounting platform, the top end of the inner cavity of the second hopper is connected to the bottom end of the inner cavity of the slot housing, and the bottom end of the second hopper is connected to the feeding port; the storage housing is installed on the bottom right side of the first and second conveying cylinders and connected to the discharge ports of the first and second conveying cylinders, and the bottom end of the inner cavity of the storage housing is connected to the top end of the inner cavity of the slot housing; the weighing sensor is installed in the inner cavity of the storage housing, and the weighing sensor is electrically connected to the control console.

[0014] Compared with the prior art, the beneficial effects of the present invention are: 1. Improve automation and reduce human intervention: By linking the control console with the material hoist, solution pump station and solid raw material feeding device, the entire process of solid raw material hoisting, conveying and feeding, and liquid raw material storage and dispensing is automated, reducing human operation errors. At the same time, the raw materials are transported through a closed channel to avoid cross-contamination caused by human contact, which meets the GMP requirements for pharmaceutical production.

[0015] 2. Optimize the feeding method to avoid excessively high local concentrations: With the cooperation of the feeding component and the storage unit, solid raw materials can be inserted into the reaction liquid below the surface during the rotation gap of the stirring rod, and then dispersed into the liquid through the mesh cover. This solves the problem of raw materials accumulating on the liquid surface in traditional devices, reduces side reactions, and ensures the purity of intermediates.

[0016] 4. Improve the mixing effect and enhance the uniformity of mixing: The mixing mechanism has multiple mixing modes. It can achieve continuous mixing in the liquid raw material mixing stage and intermittent mixing in the solid raw material feeding stage, while reserving space for feeding. Mixing and feeding are carried out simultaneously during feeding, eliminating mixing dead zones and improving the uniformity of raw material mixing.

[0017] 5. Achieve quantitative conveying and ensure accurate proportioning: The solid raw material feeding device adopts a double conveying cylinder design, which can adjust the feeding flow rate according to needs. In conjunction with the weighing sensor in the storage shell, the weight is fed back in real time, accurately controlling the total amount of material fed and avoiding proportioning deviation.

[0018] In summary, this invention employs an automated material feeding and solution addition method, reducing manual intervention and operational errors. It also enables the material to be fed from inside the liquid in the reactor, while simultaneously using a stirrer to rapidly mix the material with the reaction liquid, thereby improving reaction efficiency and reducing the accumulation of material on the liquid surface to avoid excessively high local concentrations. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of the present invention; Figure 2 for Figure 1 Exploded view of the mixing device in the image; Figure 3 for Figure 2 Exploded view of the mixing mechanism in the image; Figure 4 for Figure 3 Enlarged view of point A in the image; Figure 5 for Figure 3 Exploded view of the feeding component in the middle; Figure 6 for Figure 5 Exploded view of the memory cells in the diagram; Figure 7 for Figure 1Exploded view of the solid raw material feeding device in the image; Figure 8 for Figure 7 Enlarged view of point B in the image.

[0020] In the diagram: 1. Workbench; 2. Mixing device; 21. Base; 22. Main body of mixing device; 23. Temperature control device; 24. Top cover; 25. First motor; 3. Stirring and mixing mechanism; 31. Truss; 32. Grooved wheel; 33. First electromagnetic clutch; 34. Transmission belt assembly; 35. First mounting base; 36. Drive wheel; 37. Cam; 38. Second electromagnetic clutch; 39. Second motor; 310. Bevel gear assembly; 311. Second mounting base; 312. U-shaped connecting rod; 313. First drive rod; 314. Rotating rod; 315. Third mounting base; 316. First connecting rod; 317. Spring connecting rod; 318. Connecting pin; 319. Stirring rod; 4. Feeding component; 41. Outer shell; 42. Insertion hole; 43. Feeding port; 44. Insert rod; 45. Slide frame; 46. Connecting frame; 5. Storage unit; 51. Storage cylinder; 52. Mesh cover; 53. First sealing cover; 54. Second sealing cover; 55. Third connecting rod; 56. Micro motor; 57. Second drive rod; 58. Second connecting rod; 6. Solid raw material feeding device; 61. Base frame; 62. First mounting platform; 63. First conveying cylinder; 64. Second conveying cylinder; 65. Cover shell; 66. Third motor; 67. First screw conveyor rod; 68. Fourth motor; 69. Second screw conveyor rod; 610. First hopper; 611. Vibrating feeder; 612. Connecting pipe; 613. Second mounting platform; 614. Slot shell; 615. Sealing plate; 616. Electric telescopic rod; 617. Second hopper; 618. Storage shell; 619. Weighing sensor; 7. Material elevator; 8. Solution pump station; 9. Control console. Detailed Implementation

[0021] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0022] Please see Figures 1-8This invention provides a technical solution: a mixing device for processing pharmaceutical intermediates, comprising: a workbench 1, a mixing device 2, a solid raw material feeding device 6, a material elevator 7, a solution pump station 8, and a control console 9; the mixing device 2 is located inside the workbench 1; the solid raw material feeding device 6 is located on top of the mixing mechanism 3; the material elevator 7 is located at the left front of the workbench 1, and is controlled by the control console 9, capable of lifting sodium sulfite to a specified height; the solution pump station 8 is located at the front of the workbench 1, and is controlled by the control console 9, the solution pump station 8 having a heating module inside capable of storing various types of solutions, and the solution pump station 8 sequentially pumps the stored solutions into the mixing device body 22; the control console 9 is installed on top of the workbench 1, and the material elevator 7 and the solution pump station 8 are electrically connected to the control console 9, the control console 9 having a preset program, capable of manual operation or automated control according to actual needs.

[0023] As a preferred option, further, such as Figure 2 As shown, the mixing device 2 includes: a base 21, a mixing device body 22, a temperature control device 23, a top cover 24, a first motor 25, and a stirring and mixing mechanism 3; the base 21 is located on the inner bottom of the workbench 1; the mixing device body 22 is installed on top of the base 21, and the liquid inlet of the mixing device body 22 is connected to the solution pump station 8 through a pipe; a temperature sensor and a pH sensor are installed inside the mixing device body 22 as needed to realize real-time monitoring of the internal temperature and pH value of the mixing device body 22; the temperature control device 23 is located inside the base 21, and the temperature control device 23 is connected to the mixing device body 22 through a pipe. Temperature control device 23 is electrically connected to control console 9. Temperature control device 23 is controlled by control console 9. Temperature control device 23 heats the interior of mixing device body 22 to a specified temperature. Top cover 24 is installed on the top of the inner cavity of mixing device body 22. First motor 25 is installed on the top right side of top cover 24. Rotating end of first motor 25 extends out of the lower surface of top cover 24. First motor 25 is electrically connected to control console 9. First motor 25 is controlled by control console 9. First motor 25 can drive one end of pulley of transmission belt assembly 34 to rotate clockwise or counterclockwise. Stirring and mixing mechanism 3 is set on the top of the inner cavity of mixing device body 22.

[0024] As a preferred option, further, such as Figure 3 and Figure 4As shown, the mixing mechanism 3 includes: a truss 31, a grooved wheel 32, a first electromagnetic clutch 33, a transmission belt assembly 34, a first mounting base 35, a drive wheel 36, a cam 37, a second electromagnetic clutch 38, a second motor 39, a bevel gear assembly 310, a second mounting base 311, a U-shaped connecting rod 312, a first drive rod 313, a rotating rod 314, a third mounting base 315, a first connecting rod 316, a spring connecting rod 317, a connecting pin 318, a mixing rod 319, and a feeding component 4; the truss 31 is arranged at the top of the inner cavity of the mixing device body 22 in the front-rear direction; the grooved wheel 32 is rotatably connected to the middle of the truss 31 through a bearing; one end of the first electromagnetic clutch 33 is connected to the top of the shaft of the grooved wheel 32, and the first electromagnetic clutch... The device 33 and the control console 9 are electrically connected. The first electromagnetic clutch 33 is controlled by the control console 9 and can adjust the connection state between the pulley 32 and one end of the pulley of the transmission belt assembly 34. One end of the transmission belt assembly 34 is mounted on the bottom of the rotating end of the first motor 25, and the other end of the transmission belt assembly 34 is connected to the other end of the first electromagnetic clutch 33. The transmission belt assembly 34 adopts a structure in which the transmission belt is sleeved on the outside of the pulleys on both sides. The first mounting base 35 is mounted on the bottom right side of the top cover 24. The drive wheel 36 is rotatably connected to the bottom left side of the first mounting base 35 through a rotating shaft. The shaft of the drive wheel 36 extends into the inside of the first mounting base 35, and a pin is provided inside the drive wheel 36 to enable it to move on its own. A constant speed rotation simultaneously drives the pin to rotate continuously in the circumferential direction, allowing the pin to intermittently enter the groove of the grooved wheel 32; the cam 37 is mounted on the right end of the shaft of the drive wheel 36; the second electromagnetic clutch 38 is mounted on the bottom right side of the inner side of the first mounting base 35, one end of the second electromagnetic clutch 38 is connected to the right end of the shaft of the cam 37, the second electromagnetic clutch 38 is electrically connected to the control console 9, the second electromagnetic clutch 38 is controlled by the control console 9, and the second electromagnetic clutch 38 can adjust the connection state between the cam 37 and the bevel gear at one end of the bevel gear assembly 310; the second motor 39 is mounted on the top right end of the top cover 24, the rotating end of the second motor 39 extends to the lower surface of the top cover 24, the second motor 39 is electrically connected to the control console 9, and the second motor 39... Controlled by console 9, the second motor 39 drives the bevel gear assembly 310 to rotate at one end; the bevel gear assembly 310 is mounted at the bottom of the rotating end of the second motor 39, and the bevel gear assembly 310 is mounted on the outer side of the other end of the second electromagnetic clutch 38. The bevel gear assembly 310 adopts a 90-degree meshing structure of bevel gears on both sides; the second mounting base 311 is located at the front side of the middle of the bottom end of the top cover 24; the U-shaped connecting rod 312 is rotatably connected to the inner bottom end of the second mounting base 311 through bearings, and the shaft of the U-shaped connecting rod 312 extends out of the outside of the second mounting base 311 on both the left and right sides. The U-shaped connecting rod 312 can swing up or down at the inner bottom end of the second mounting base 311.The first drive rod 313 is installed at the right end of the shaft of the U-shaped connecting rod 312, and the rear side of the bottom end of the first drive rod 313 contacts the outside of the cam 37; the rotating rod 314 is installed at the left end of the shaft of the U-shaped connecting rod 312; the third mounting seat 315 is installed in the vertical direction at the left front of the bottom end of the top cover 24; one end of the first connecting rod 316 is rotatably connected to the left bottom end of the third mounting seat 315 via a rotating shaft; one end of the spring connecting rod 317 is connected to the outer front end of the rotating rod 314 via a rotating shaft, and the inner side of the other end of the spring connecting rod 317 is connected to the outside of the first connecting rod 316 via a rotating shaft, and the inner side of the spring connecting rod 317 adopts a flexible connection with a spring structure; the connecting pin 318 is installed on the left side of the other end of the first connecting rod 316; the stirring rod 319 is installed at the bottom end of the shaft of the grooved wheel 32; the feeding component 4 is installed on the left side of the bottom end of the top cover 24.

[0025] As a preferred option, further, such as Figure 5 As shown, the feeding component 4 includes: a housing 41, insertion holes 42, a feeding port 43, insertion rods 44, a chute frame 45, a connecting frame 46, and a storage unit 5; the housing 41 is installed vertically at the left opening of the top cover 24; there are two insertion holes 42, which are respectively opened at the front and rear ends of the bottom right side of the housing 41; the feeding port 43 is opened at the top of the inner cavity of the housing 41; there are two insertion rods 44, which are respectively inserted into the bottom of the inner cavity of the front and rear insertion holes 42, and the insertion rods 44 can move up and down in the inner cavity of the insertion holes 42; the chute frame 45 is installed at the bottom of the front and rear insertion rods 44, and a connecting pin 318 is inserted into the inner cavity of the chute frame 45, and the connecting pin 318 can move back and forth in the inner cavity of the chute frame 45; the connecting frame 46 is installed on the left side of the chute frame 45; the storage unit 5 is located inside the connecting frame 46.

[0026] As a preferred option, further, such as Figure 6As shown, the storage unit 5 includes: a storage cylinder 51, a mesh cover 52, a first sealing cover 53, a second sealing cover 54, a third connecting rod 55, a micro motor 56, a second drive rod 57, and a second connecting rod 58; the storage cylinder 51 is installed inside the connecting frame 46 in the vertical direction, and the top of the storage cylinder 51 extends into the inner cavity of the outer shell 41; the mesh cover 52 is detachably installed at the bottom end of the inner cavity of the storage cylinder 51; the first sealing cover 53 is rotatably connected to the bottom left side of the outer wall of the storage cylinder 51 via a rotating shaft; the second sealing cover 54 is rotatably connected to the outside of the first sealing cover 53 via a rotating shaft and is located at the bottom right side of the outer wall of the storage cylinder 51, and the first sealing cover 53 and the second sealing cover 54 can seal the storage cylinder 51 after the bottom end of the outer wall is closed; there are two third connecting rods 55. One end of rod 55 is respectively installed at the front end of the shaft core of the first sealing cover 53 and the second sealing cover 54; there are two micro motors 56, which are installed at the bottom of the left and right sides of the outer wall of the storage cylinder 51. The micro motors 56 are electrically connected to the control console 9 and are controlled by the control console 9. The micro motors 56 can drive the second drive rod 57 to rotate clockwise or counterclockwise; there are two second drive rods 57, one end of which is respectively installed in front of the rotating end of the two micro motors 56; there are two second connecting rods 58, one end of which is connected to the other end of the two second drive rods 57 through a rotating shaft, and the other end of which is connected to the other end of the two third connecting rods 55 through a rotating shaft.

[0027] As a preferred option, further, such as Figure 7 and Figure 8As shown, the solid raw material feeding device 6 includes: a base frame 61, a first mounting platform 62, a first conveying cylinder 63, a second conveying cylinder 64, a cover shell 65, a third motor 66, a first spiral conveying rod 67, a fourth motor 68, a second spiral conveying rod 69, a first hopper 610, a vibrating feeder 611, a connecting pipe 612, a second mounting platform 613, a slot shell 614, a sealing plate 615, an electric telescopic rod 616, a second hopper 617, a storage shell 618, and a weighing sensor 619; the base frame 61 is installed vertically on the top left side of the workbench 1; the first mounting platform 62 is fixedly installed on the top of the base frame 61; the first conveying cylinder 63 is installed horizontally via a bracket. The first mounting platform 62 is located on the top rear side; the second conveying cylinder 64 is mounted on the top front side of the first mounting platform 62 along the left-right direction via a bracket. The inner diameter of the second conveying cylinder 64 is smaller than that of the first conveying cylinder 63. The first conveying cylinder 63 is responsible for conveying large flow rates of material, while the second conveying cylinder 64 is used for fine-tuning the material flow rate. The first conveying cylinder 63 provides the basic flow rate, and the second conveying cylinder 64 performs fine adjustments to achieve high-precision quantitative feeding. The outer shell 65 is installed on the left side of the first mounting platform 62. The third motor 66 is located on the rear side of the inner cavity of the outer shell 65. The rotating end of the third motor 66 extends into the inner cavity of the first conveying cylinder 63. The third motor 66 is electrically connected to the control console 9. Controlled by console 9, the third motor 66 drives the first spiral conveyor rod 67 to rotate. The first spiral conveyor rod 67 is installed in the left-right direction at the rotating end of the third motor 66 and is located inside the cavity of the first conveying cylinder 63. The fourth motor 68 is located on the front side of the cavity of the outer shell 65, and the rotating end of the fourth motor 68 extends into the cavity of the second conveying cylinder 64. The fourth motor 68 is electrically connected to console 9 and is controlled by console 9. The fourth motor 68 drives the second spiral conveyor rod 69 to rotate. The second spiral conveyor rod 69 is installed in the left-right direction at the rotating end of the fourth motor 68 and is located inside the cavity of the second conveying cylinder 64. The first hopper 610 is installed in the first conveying cylinder. Above the feed inlet of the second conveyor cylinder 64; the vibrating feeder 611 is installed on the top of the inner cavity of the first hopper 610, and is electrically connected to the control console 9. The vibrating feeder 611 is controlled by the control console 9 and can discharge sodium sulfite particles inside it through vibration; one end of the connecting pipe 612 is connected to the feed inlet of the vibrating feeder 611, and the other end of the connecting pipe 612 is connected to the discharge port of the material elevator 7; the second mounting platform 613 is installed outside the base frame 61 and below the first mounting platform 62; the slot housing 614 is installed on the top right side of the second mounting platform 613; the sealing plate 615 is inserted into the inner cavity of the slot housing 614;Two electric telescopic rods 616 are installed at the front and rear ends of the top left side of the second mounting platform 613, respectively. The telescopic ends of the two electric telescopic rods 616 are connected to the front and rear ends of the left side of the sealing plate 615. The electric telescopic rods 616 are electrically connected to the control console 9 and are controlled by the control console 9. The electric telescopic rods 616 drive the sealing plate 615 to move left and right within the cavity of the slot housing 614 by extending and shortening themselves. The second hopper 617 is installed inside the right opening of the second mounting platform 613. The top of the inner cavity of the second hopper 617 is connected to the slot housing 614. The bottom of the inner cavity is connected, and the bottom of the second hopper 617 is connected to the feeding port 43; the storage shell 618 is installed on the right side of the bottom of the first conveying cylinder 63 and the second conveying cylinder 64 and is connected to the discharge port of the first conveying cylinder 63 and the second conveying cylinder 64. The bottom of the inner cavity of the storage shell 618 is connected to the top of the inner cavity of the slot shell 614; the weighing sensor 619 is installed in the inner cavity of the storage shell 618, and the weighing sensor 619 is electrically connected to the control console 9. The weighing sensor 619 is controlled by the control console 9 and can weigh the sodium sulfite particles in the inner cavity of the storage shell 618.

[0028] The working principle is as follows: Step 1: The operator controls the control console 9 to start the solution pump station 8, the first motor 25, the material elevator 7, the vibrating feeder 611, the third motor 66, the fourth motor 68, the weighing sensor 619, and the electric telescopic rod 616. The solution pump station 8 sequentially discharges the internally stored deionized water and phosphoric acid into the inner cavity of the mixing device body 22 through the internal inlet. The first motor 25, driven by the transmission belt assembly 34, drives the grooved wheel 32 to rotate through the first electromagnetic clutch 33, which in turn drives the stirring rod 319 to rotate, so that the stirring rod 319 stirs the phosphoric acid in the inner cavity of the grooved wheel 32 until it is completely dissolved, forming a uniform phosphoric acid solution. The material elevator 7 lifts the internally stored sodium sulfite particles to a designated height and enters the vibrating feeder 611 through the connecting pipe 612. The vibrating feeder 611, through its own vibration, feeds the internal sodium sulfite particles from the first hopper 610 into the first conveying cylinder 63 and the second conveying cylinder 616. Inside the second conveying cylinder 64, the third motor 66 and the fourth motor 68 respectively drive the first spiral conveying rod 67 and the second spiral conveying rod 69 at corresponding positions to rotate inside the first conveying cylinder 63 and the second conveying cylinder 64. Under the action of the rotational force of the first spiral conveying rod 67 and the second spiral conveying rod 69, the sodium sulfite particles are conveyed along the inner cavity of the first conveying cylinder 63 and the second conveying cylinder 64 to the inner cavity of the storage shell 618. The weighing sensor 619 weighs the sodium sulfite particles in the inner cavity of the storage shell 618 until they meet the usage requirements. Then, the third motor 66 and the fourth motor 68 stop driving the first spiral conveying rod 67 and the second spiral conveying rod 69 to rotate. The electric telescopic rod 616 shortens and drives the sealing plate 615 to move to the left in the inner cavity of the slot shell 614 to release the seal on the inner cavity of the slot shell 614. The sodium sulfite particles inside the storage shell 618 are poured into the inner cavity of the storage cylinder 51 through the inner cavity of the feeding port 43 by the slot shell 614 and the second hopper 617. Step 2: The operator controls the console 9 to activate the first electromagnetic clutch 33, the second electromagnetic clutch 38, the second motor 39, the micro motor 56, and the temperature control device 23. The first electromagnetic clutch 33 stops the transmission connection between the pulley shaft of the grooved pulley 32 and the corresponding position of the belt pulley shaft of the transmission belt assembly 34. The second electromagnetic clutch 38 realizes the transmission connection between the shaft of the cam 37 and the shaft of the bevel gear assembly 310 on one side. The second motor 39 drives the cam 37 to rotate under the transmission of the bevel gear assembly 310 and the second electromagnetic clutch 38, so that the cam 37 drives the drive wheel itself. As cam 36 rotates, the outer end of cam 37 intermittently contacts the lower surface of the first drive rod 313 at its far-hub end and near-hub end. Drive wheel 36 drives pin to rotate continuously in the circumferential direction at a constant speed. When the pin inside drive wheel 36 intermittently enters the groove of groove wheel 32, the rotational motion of drive wheel 36 is transmitted to groove wheel 32 through pin, causing groove wheel 32 to drive stirring rod 319 to rotate intermittently. Under the rotational force of spring connecting rod 317, first drive rod 313 drives U-shaped connecting rod 312 to swing up or down inside second mounting base 311, and causes U-shaped connecting rod 312 to drive rotating rod 314. One end rotates intermittently upwards or downwards, causing the rotating rod 314, in cooperation with the spring connecting rod 317, to drive the first connecting rod 316 to rotate intermittently upwards or downwards outside the third mounting base 315. The first connecting rod 316 drives the connecting pin 318 to reciprocate up and down within the slide frame 45, which is transmitted to the connecting frame 46 through the limiting action of the insert rod 44. The connecting frame 46 drives the storage unit 5 to insert below the liquid surface when the stirring rod 319 rotates to the empty position. The micro motors 56 on both sides drive the second driving rods 57 at the corresponding positions to rotate, so that the second driving rods 57 on both sides are at the corresponding positions. With the cooperation of the second connecting rod 58, one end of the third connecting rod 55 is driven to rotate upward, thereby causing the third connecting rods 55 on both sides to drive the first sealing cover 53 and the second sealing cover 54 to rotate outward and release the seal on the bottom of the mesh cover 52. The sodium sulfite particles stored inside the storage cylinder 51 enter the phosphoric acid solution through the pores inside the mesh cover 52. During the addition process, the stirring rod 319 is continuously rotated and stirred. After the sodium sulfite particles are added, the temperature control device 23 heats the inside of the mixing device body 22 to control the reaction temperature of the inner cavity of the mixing device body 22 at 60℃-80℃.

[0029] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A mixing apparatus for processing pharmaceutical intermediates, characterized in that, include: Workbench (1); A mixing device (2) is disposed inside the workbench (1); A solid raw material feeding device (6) is installed on top of the stirring and mixing mechanism (3); The material hoist (7) is located to the left front of the workbench (1); A solution pump station (8) is located on the front side of the workbench (1); The control console (9) is installed on top of the workbench (1), and the material elevator (7) and the solution pump station (8) are electrically connected to the control console (9); The mixing device (2) includes: The base (21) is located at the bottom inner side of the workbench (1); The mixing device body (22) is installed on the top of the base (21), and the liquid inlet of the mixing device body (22) is connected to the solution pump station (8) through a pipe; Temperature control device (23) is installed inside the base (21). The temperature control device (23) and the mixing device body (22) are connected by a pipe. The temperature control device (23) and the control console (9) are electrically connected. The top cover (24) is installed on the top of the inner cavity of the mixing device body (22); The first motor (25) is installed on the right side of the top of the top cover (24), the rotating end of the first motor (25) extends out of the lower surface of the top cover (24), and the first motor (25) is electrically connected to the control console (9). The stirring and mixing mechanism (3) is located at the top of the inner cavity of the mixing device body (22).

2. The mixing apparatus for processing pharmaceutical intermediates according to claim 1, characterized in that, The stirring and mixing mechanism (3) includes: A truss (31) is arranged at the top of the inner cavity of the main body (22) of the mixing device in the front-back direction; The grooved wheel (32) is rotatably connected to the middle of the truss (31) via a bearing; The first electromagnetic clutch (33) is connected at one end to the top of the shaft of the grooved wheel (32), and the first electromagnetic clutch (33) is electrically connected to the control console (9); The transmission belt assembly (34) has a pulley at one end installed at the bottom of the rotating end of the first motor (25), and the pulley at the other end of the transmission belt assembly (34) is connected to the other end of the first electromagnetic clutch (33). The first mounting base (35) is installed on the bottom right side of the top cover (24); The drive wheel (36) is rotatably connected to the bottom left side of the first mounting base (35) via a rotating shaft, and the shaft of the drive wheel (36) extends into the inside of the first mounting base (35); Cam (37) is mounted on the right end of the shaft of the drive wheel (36); The second electromagnetic clutch (38) is installed on the bottom right side of the first mounting base (35). One end of the second electromagnetic clutch (38) is connected to the right end of the shaft of the cam (37). The second electromagnetic clutch (38) is electrically connected to the control console (9).

3. The mixing apparatus for processing pharmaceutical intermediates according to claim 2, characterized in that, The stirring and mixing mechanism (3) also includes: The second motor (39) is installed at the top right end of the top cover (24), the rotating end of the second motor (39) extends to the lower surface of the top cover (24), and the second motor (39) is electrically connected to the control console (9). A bevel gear assembly (310) has a bevel gear at one end mounted on the bottom of the rotating end of the second motor (39), and a bevel gear at the other end mounted on the outer side of the other end of the second electromagnetic clutch (38). The second mounting base (311) is disposed on the front side of the middle of the bottom end of the top cover (24); The U-shaped connecting rod (312) is rotatably connected to the inner bottom end of the second mounting base (311) via a bearing, and the shaft of the U-shaped connecting rod (312) extends out of the second mounting base (311) on both the left and right sides. The first drive rod (313) is installed on the right end of the shaft of the U-shaped connecting rod (312), and the rear side of the bottom end of the first drive rod (313) is in contact with the outside of the cam (37). Rotating rod (314) is installed on the left end of the shaft of the U-shaped connecting rod (312).

4. The mixing apparatus for processing pharmaceutical intermediates according to claim 3, characterized in that, The stirring and mixing mechanism (3) also includes: The third mounting base (315) is installed in the vertical direction at the bottom left front of the top cover (24); The first connecting rod (316) is rotatably connected at one end to the bottom left side of the third mounting base (315) via a rotating shaft; A spring connecting rod (317) is connected at one end to the outer front end of the rotating rod (314) via a pivot, and the inner side of the other end of the spring connecting rod (317) is connected to the outer side of the first connecting rod (316) via a pivot. A connecting pin (318) is installed on the left side of the other end of the first connecting rod (316); A stirring rod (319) is installed at the bottom end of the shaft of the grooved wheel (32); The feeding component (4) is installed on the left side of the bottom end of the top cover (24).

5. A mixing apparatus for processing pharmaceutical intermediates according to claim 4, characterized in that, The feeding component (4) includes: The outer casing (41) is installed in the vertical direction at the left opening of the top cover (24); The number of sockets (42) is two, and the two sockets (42) are respectively opened at the front and rear ends of the bottom right side of the outer casing (41); The feeding port (43) is located at the top of the inner cavity of the outer shell (41); Insert rod (44), there are two insert rods (44), and the two insert rods (44) are respectively inserted into the bottom of the inner cavity of the front and rear insertion holes (42); The slide frame (45) is installed at the bottom end of the front and rear insert rods (44), and the connecting pin (318) is inserted into the inner cavity of the slide frame (45); A connecting bracket (46) is installed on the left side of the slide rail bracket (45); The storage unit (5) is disposed inside the connecting frame (46).

6. The mixing apparatus for processing pharmaceutical intermediates according to claim 5, characterized in that, The storage unit (5) includes: Storage cylinder (51) is installed inside the connecting frame (46) in the vertical direction, and the top end of the storage cylinder (51) extends into the inner cavity of the outer shell (41); A mesh cover (52) is detachably installed at the bottom of the inner cavity of the storage cylinder (51); The first sealing cover (53) is rotatably connected to the bottom left side of the outer wall of the storage cylinder (51) via a rotating shaft; The second sealing cover (54) is rotatably connected to the outside of the first sealing cover (53) via a rotating shaft and is located on the bottom right side of the outer wall of the storage cylinder (51); The third connecting rod (55) has two parts, and one end of each of the two third connecting rods (55) is respectively installed at the front end of the shaft core of the first sealing cover (53) and the second sealing cover (54); Two micro motors (56) are installed on the bottom left and right sides of the outer wall of the storage cylinder (51). The micro motors (56) are electrically connected to the control console (9). The second drive rod (57) has two parts, and one end of each of the two second drive rods (57) is installed on the front side of the rotating end of each of the two micro motors (56). The second connecting rod (58) has two ends. One end of each of the two second connecting rods (58) is connected to the other end of each of the two second driving rods (57) via a rotating shaft. The other end of each of the two second connecting rods (58) is connected to the other end of each of the two third connecting rods (55) via a rotating shaft.

7. A mixing apparatus for processing pharmaceutical intermediates according to claim 6, characterized in that, The solid raw material feeding device (6) includes: The base frame (61) is installed on the top left side of the workbench (1) in the vertical direction; The first mounting platform (62) is fixedly mounted on the top of the base frame (61); The first conveying cylinder (63) is mounted on the top rear side of the first mounting platform (62) via a bracket in the left-right direction; The second conveying cylinder (64) is mounted on the top front side of the first mounting platform (62) via a bracket in the left-right direction. The inner diameter of the second conveying cylinder (64) is smaller than the inner diameter of the first conveying cylinder (63). The outer shell (65) is installed on the left side of the first mounting platform (62).

8. A mixing apparatus for processing pharmaceutical intermediates according to claim 7, characterized in that, The solid raw material feeding device (6) also includes: The third motor (66) is located on the rear side of the inner cavity of the outer shell (65). The rotating end of the third motor (66) extends into the inner cavity of the first conveying cylinder (63). The third motor (66) is electrically connected to the control console (9). The first spiral conveying rod (67) is installed in the left-right direction at the rotating end of the third motor (66) and located in the inner cavity of the first conveying cylinder (63); A fourth motor (68) is disposed on the front side of the inner cavity of the outer shell (65) of the cover. The rotating end of the fourth motor (68) extends into the inner cavity of the second conveying cylinder (64). The fourth motor (68) is electrically connected to the control console (9). The second spiral conveyor rod (69) is installed in the left-right direction at the rotating end of the fourth motor (68) and located in the inner cavity of the second conveyor cylinder (64); The first hopper (610) is installed above the feed inlets of the first conveying cylinder (63) and the second conveying cylinder (64); A vibrating feeder (611) is installed on the top of the inner cavity of the first hopper (610), and the vibrating feeder (611) is electrically connected to the control console (9); The connecting pipe (612) is connected at one end to the feed port of the vibrating feeder (611) and at the other end to the discharge port of the material elevator (7).

9. A mixing apparatus for processing pharmaceutical intermediates according to claim 8, characterized in that, The solid raw material feeding device (6) also includes: The second mounting platform (613) is mounted outside the base frame (61) and located below the first mounting platform (62); The slot housing (614) is mounted on the top right side of the second mounting platform (613); A sealing plate (615) is inserted into the inner cavity of the slot housing (614); Electric telescopic rod (616), the number of electric telescopic rods (616) is two, the two electric telescopic rods (616) are respectively installed on the front and rear ends of the top left side of the second mounting platform (613), the telescopic ends of the two electric telescopic rods (616) are connected to the front and rear ends of the left side of the sealing plate (615), and the electric telescopic rods (616) are electrically connected to the control console (9); The second hopper (617) is installed inside the right opening of the second mounting platform (613). The top of the inner cavity of the second hopper (617) is connected to the bottom of the inner cavity of the slot shell (614), and the bottom of the second hopper (617) is connected to the feeding port (43). Storage housing (618) is installed on the right side of the bottom end of the first conveying cylinder (63) and the second conveying cylinder (64) and connected to the discharge port of the first conveying cylinder (63) and the second conveying cylinder (64). The bottom end of the inner cavity of the storage housing (618) is connected to the top end of the inner cavity of the slot housing (614). A weighing sensor (619) is installed in the inner cavity of the storage housing (618), and the weighing sensor (619) is electrically connected to the control console (9).

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