Liquid chromatograph temperature control device

Abstract

The invention relates to the technical field of liquid chromatograms, in particular to a liquid chromatograph temperature control device which comprises a guide rail, a sliding block is slidably connected to the inner side of the guide rail, a fixing frame is fixedly mounted at the outer end of the sliding block, a driving mechanism is fixedly mounted on the inner side of the fixing frame, and the driving mechanism is fixedly connected with the sliding block. A concave base is fixedly installed on the side, away from the guide rail, of the fixing frame. According to the device, the temperature control mechanism is arranged, so that the device can rapidly heat or cool a sample introduction disc for placing a sample vessel with a sample, during heating, an annular electric heating plate is attached to the bottom of the sample vessel for rapid heating, and the temperature change is monitored through a temperature sensor; during cooling, the circulating pump is started, water liquid is driven to flow in the heat conduction coil pipe and exchange heat with the sample vessel, meanwhile, the semiconductor cooler is used for cooling the cooling liquid in the water tank, so that the sample vessel is rapidly cooled, the temperature regulation and control reaction change rate of the device is high, and the overall temperature regulation and control performance is improved.

Description

Technical Field

[0001] This application relates to the technical field of liquid chromatography, and in particular to a temperature control device for a liquid chromatograph. Background Technology

[0002] A liquid chromatograph (LC) is a primary instrument used for liquid chromatographic separation. Its working principle is based on the difference in partition ratios between a mixture and a solid or two immiscible liquids. Specifically, LC achieves sample separation through two physicochemical processes: partition and adsorption. Partition involves the distribution of the sample between the mobile and stationary phases; different components are separated to varying degrees between the two phases due to their different partition coefficients. Adsorption, on the other hand, involves the adsorption of sample molecules onto an adsorbent present on the surface of the stationary phase, thus achieving separation. After these interactions occur between the mobile and stationary phases, the sample is separated into different components, which are then progressively separated within the column. When the sample components reach the detector, the detector converts the signal into an electrical signal. After amplification, filtering, and other processing, the signal is transmitted to a computer system for data processing and analysis.

[0003] In the field of chemical detection, chromatography plays a crucial role. Its key characteristic is the need to prevent contamination of the injected reagents. Therefore, sample plates are frequently used in liquid chromatography-tandem mass spectrometry (LC-MS) for sample analysis. However, existing sample plates lack a covering device, failing to effectively prevent the evaporation of volatile liquids during experiments. This is especially problematic during continuous injection, where longer injection times lead to greater sample liquid loss. Furthermore, the close proximity of the wells on the sample plate means that improper operation during sample solution addition can result in the pipette dripping into adjacent wells or overflowing and contaminating adjacent wells. Additionally, vibrations during plate movement can cause liquid in the wells to spill, leading to cross-contamination.

[0004] A search revealed Chinese Patent Publication No. CN211856483U, which discloses a sample injection plate for a liquid chromatography or liquid chromatography-tandem mass spectrometry (LC-MS / MS) instrument. The plate includes a rectangular base plate, injection ports, a groove on one side of the base plate, and a cover plate of the same size as the base plate. The cover plate has round caps of the same size and number as the injection ports on the base plate. The cover plate has protrusions that engage with the grooves when closed. The cover plate also has creases for folding. Alternatively, the cover plate can be a strip-shaped cover, with a length equal to the base plate and a width sufficient to cover only one row of injection ports on the base plate. This sample injection plate can reduce liquid splashing into adjacent ports due to improper operation, prevent inaccurate test results caused by different liquid evaporation rates, avoid cross-contamination of reagents, and prevent reagent spillage due to instrument vibration.

[0005] Regarding the aforementioned related technologies, the inventors have discovered the following drawbacks:

[0006] While the aforementioned device provides a degree of sealing and spill prevention during use, it lacks a corresponding heating structure and temperature control function. Temperature variations affect the flowability of the sample solvent and separation efficiency. The absence of a temperature control structure means that the temperature on the injection plate may not remain stable, leading to significant viscous heat generated by friction between the column and the mobile phase, affecting the temperature distribution within the column. This can cause changes in the viscosity of the mobile phase before it enters the column, impacting its flow characteristics under high pressure and ultimately reducing separation efficiency. A control structure is crucial for the injection plate in liquid chromatography, improving separation efficiency and analytical stability, as well as ensuring data quality and instrument durability. Clearly, the aforementioned device lacks flexible temperature control, failing to flexibly increase or decrease the temperature quickly when cooling is needed. Therefore, it has certain shortcomings and deficiencies that require improvement. Summary of the Invention

[0007] In order to improve the overall temperature control accuracy and convenience of the device and thus enhance its testing convenience, this application provides a temperature control device for a liquid chromatograph.

[0008] This application provides a temperature control device for a liquid chromatograph, which adopts the following technical solution: it includes a guide rail, a slider is slidably connected to the inner side of the guide rail, a fixed frame is fixedly installed at the outer end of the slider, a driving mechanism is fixedly installed on the inner side of the fixed frame, a concave seat is fixedly installed on the side of the fixed frame away from the guide rail, displacement mechanisms are fixedly installed on both sides of the inner side of the concave seat, an injection plate is fixedly installed on the inner side of one of the two displacement mechanisms, a temperature control mechanism is fixedly installed at the bottom of the injection plate, and a sealing mechanism is fixedly installed on the inner side of the other of the two displacement mechanisms, the sealing mechanism covering the top of the injection mechanism;

[0009] The temperature control mechanism includes a holding component and a water tank. The holding component is fixedly installed at equal intervals on the inner side of the sample injection tray. The water tank is fixedly installed on one side of the bottom of the sample injection tray. A circulation pump is fixedly installed on one side of the water tank. The input end of the circulation pump is connected to the water tank. A transfer coil is fixedly installed on the output end of the circulation pump. The transfer coil is connected to the holding component. The output end of the holding component is connected to the inside of the water tank. A semiconductor cooler is fixedly installed at the bottom of the water tank.

[0010] Optionally, the holding assembly includes a placement seat, which is fixedly installed at equal intervals on the inner side of the sample inlet tray. A heat-conducting coil is fixedly installed on the inner side of the placement seat. The transfer coil and each heat-conducting coil are connected in series. The main body of the heat-conducting coil is coiled on the inner side of the placement seat. A sample dish is inserted into the inner side of the placement seat.

[0011] Optionally, an annular electric heating plate is fixedly installed at the bottom of the placement seat, a temperature sensor is fixedly installed in the middle of the placement seat, the detection end of the temperature sensor is attached to the bottom of the sample dish, and a single-chip microcomputer control module is provided inside the semiconductor cooler.

[0012] Optionally, the displacement mechanism includes a first motor and a slide groove. The slide groove is formed on both sides of the concave seat. The first motor is fixedly installed at both ends of the concave seat near the guide rail. The output end of the first motor passes through the concave seat and is fixedly installed with a lead screw inside the slide groove. The lead screw is rotatably connected to the inside of the slide groove. A slide rod is threadedly connected to the outer surface of the lead screw. The slide rod is slidably connected to the inner side of the guide rail. The sample feeding plate is fixedly installed on the inner side of a slide rod.

[0013] Optionally, the sealing mechanism includes a side plate, which is fixedly installed on the inner side of another set of slide rods. An electric push rod is fixedly installed at the inner end of the side plate. A base frame is fixedly installed on the top of the electric push rod. A second motor is fixedly installed on the inner side of the base frame. A sealing disc is fixedly installed at the top output end of the second motor.

[0014] Optionally, sealing plugs are fixedly installed at equal intervals on the bottom of the sealing disk, and the bottom of each sealing plug is inserted into the upper part of the sample dish.

[0015] Optionally, the concave seat has a strip groove on the side near the electric push rod. The inner side of the strip groove is connected to the inside of the slide groove. A bracket is fixedly installed on the outer side of the slide rod with a side plate. The outer end of the bracket passes through the strip groove and is rotatably connected to the top of the sealing disc near the electric push rod.

[0016] Optionally, the overall cross-sectional shape of the slider and the slide rod is set to a convex shape, and the inner wall of the slide groove and the guide rail is also set to a convex shape. Wear-resistant pads are fixedly connected to the inner wall of the slide groove and the inner wall of the guide rail.

[0017] Optionally, the drive mechanism includes a dual-axis motor and a rack. The dual-axis motor is fixedly installed on the inner side of the fixed frame, and drive gears are fixedly installed at both output ends of the dual-axis motor. The rack is fixedly installed on both sides of the guide rail, and the drive gears and rack are meshed together.

[0018] Optionally, a support block is slidably connected to the rear side of the guide rail, and a support rod is fixedly installed on the outer side of the support block. The front end of the support rod is rotatably connected to the middle of the outer side of the drive gear.

[0019] In summary, this application includes the following beneficial technical effects:

[0020] 1. By incorporating a temperature control mechanism, this device can rapidly heat or cool the sample tray containing the sample. During heating, a ring-shaped electric heating plate is placed against the bottom of the sample tray for rapid heating, and temperature changes are monitored by a temperature sensor. During cooling, a circulating pump is activated to drive water to flow in the heat-conducting coil for heat exchange with the sample tray. Simultaneously, a semiconductor cooler is used to cool the coolant in the water tank, thereby achieving rapid cooling of the sample tray. This design enables the device to respond quickly to temperature changes, improving overall temperature control performance.

[0021] 2. By incorporating a drive mechanism, this device exhibits significant advantages in adjusting the sample inlet plate position. It enables flexible adjustment of the sample inlet plate height to adapt to different experimental needs, saving experimental preparation time. Simultaneously, the device features forward and backward displacement adjustment, allowing the sample inlet plate to automatically adapt to different sample inlet positions, enhancing its adaptability. This design improves the accuracy and efficiency of experimental analysis, reduces human error, and enhances experimental reliability. Furthermore, it provides convenience for researchers, simplifies the operation process, and allows them to focus more on the experiment itself, thus improving work efficiency.

[0022] 3. This device significantly improves the sealing performance of the sample dish during sample introduction by incorporating a sealing mechanism, effectively preventing sample spillage and cross-contamination, and ensuring the accuracy of experimental results. Simultaneously, the sealing plate moves synchronously when the sample introduction plate is adjusted, maintaining a sealed state, preventing sample loss, and improving experimental reliability. Furthermore, the device is easy to operate, allowing for quick loading and unloading of sample dishes, improving work efficiency. The auxiliary connection of the support enhances the stability of the sealing plate, preventing seal failure. In summary, this device boasts excellent sealing performance and is easy and stable to operate, providing researchers with efficient and accurate experimental conditions. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the overall structure in an embodiment of this application;

[0024] Figure 2 This is a rear-view structural schematic diagram of an embodiment of this application;

[0025] Figure 3 This is a schematic diagram of the structure viewed from below in an embodiment of this application;

[0026] Figure 4 This is a schematic diagram of the misaligned state of the sealing mechanism and the sample inlet plate in the embodiments of this application;

[0027] Figure 5 This is a bottom view of the sealing mechanism in an embodiment of this application;

[0028] Figure 6 This is a schematic diagram of the structure of the guide rail, slider, and drive mechanism in the embodiments of this application;

[0029] Figure 7 This is a bottom view of the structure of the container component in an embodiment of this application;

[0030] Figure 8 This is a top view of the internal structure of the container component in an embodiment of this application; Figure 9 This is a logic control diagram in the embodiments of this application.

[0031] Reference numerals: 1. Guide rail; 2. Slider; 3. Fixing frame; 4. Concave seat; 5. Drive mechanism; 51. Dual-axis motor; 52. Rack; 53. Drive gear; 54. Support block; 55. Support rod; 6. Sample inlet tray; 7. Temperature control mechanism; 71. Container assembly; 711. Placement seat; 712. Heat-conducting coil; 713. Temperature sensor; 714. Sample dish; 715. Annular electric heating plate; 72. Water tank; 73. Circulating pump; 74. Transfer coil; 75. Semiconductor cooler; 8. Sealing mechanism; 81. Side plate; 82. Electric push rod; 83. Base frame; 84. Second motor; 85. Sealing disc; 86. Sealing plug; 87. Strip groove; 88. Support; 9. Displacement mechanism; 91. First motor; 92. Slide groove; 93. Lead screw; 94. Slide rod. Detailed Implementation

[0032] The following is in conjunction with the appendix Figure 1-8 This application will be described in further detail.

[0033] This application discloses a temperature control device for a liquid chromatograph. For example... Figure 1 As shown, the system includes a guide rail 1, a slider 2 slidably connected to the inner side of the guide rail 1, a fixed frame 3 fixedly installed at the outer end of the slider 2, a drive mechanism 5 fixedly installed on the inner side of the fixed frame 3, a concave seat 4 fixedly installed on the side of the fixed frame 3 away from the guide rail 1, and displacement mechanisms 9 fixedly installed on both sides of the inner side of the concave seat 4. A sample injection plate 6 is fixedly installed on the inner side of one of the two sets of displacement mechanisms 9, a temperature control mechanism 7 is fixedly installed at the bottom of the sample injection plate 6, and a sealing mechanism 8 is fixedly installed on the inner side of the other set of displacement mechanisms 9. The sealing mechanism 8 covers the top of the sample injection mechanism.

[0034] The temperature control mechanism 7 includes a holding component 71 and a water tank 72. The holding component 71 is fixedly installed at equal intervals on the inner side of the sample injection tray 6. The water tank 72 is fixedly installed on one side of the bottom of the sample injection tray 6. A circulation pump 73 is fixedly installed on one side of the water tank 72. The input end of the circulation pump 73 is connected to the water tank 72. A transfer coil 74 is fixedly installed on the output end of the circulation pump 73. The transfer coil 74 is connected to the holding component 71. The output end of the holding component 71 is connected to the inside of the water tank 72. A semiconductor cooler 75 is fixedly installed at the bottom of the water tank 72. The device includes a guide rail 1. A slidable slider 2 is provided on the inner side of the guide rail 1. A fixing frame 3 is fixed on the outer end of the slider 2. A drive mechanism 5 is installed on the inner side of the fixing frame 3. A concave seat 4 is fixed on the other side of the fixing frame 3. Displacement mechanisms 9 are installed on both sides inside the concave seat 4. One set of displacement mechanisms 9... The sample inlet plate 6 is fixed inside the mechanism 9, and the temperature control mechanism 7 is installed at the bottom of the sample inlet plate 6. Another set of displacement mechanisms 9 fixes the sealing mechanism 8, which can cover the top of the sample inlet plate 6. The temperature control mechanism 7 consists of a holding component 71 and a water tank 72. The holding component 71 is fixedly installed at equal intervals inside the sample inlet plate 6 for placing samples. The function of the circulation pump 73 is to draw cooling liquid, such as coolant, from the water tank 72 and then pump the cooling liquid into the transfer coil 74. The transfer coil 74 is connected to the holding component 71. The cooling liquid flows in the holding component 71, absorbs the heat of the sample by contacting it and carries it away. Then, the cooling liquid flows back to the water tank 72, completing one cycle. The whole system can quickly regulate the temperature. At the same time, the holding component 71 itself has a heating function, which makes it easy for this device to flexibly control the temperature.

[0035] Please refer to Figure 8The holding assembly 71 includes a placement seat 711, which is fixedly installed at equal intervals inside the sample inlet tray 6. A heat-conducting coil 712 is fixedly installed inside the placement seat 711. A transfer coil 74 is connected in series with each heat-conducting coil 712. The main body of the heat-conducting coil 712 is coiled inside the placement seat 711. A sample dish 714 is inserted into the inside of the placement seat 711. The holding assembly 71 mainly consists of placement seats 711, which are fixedly installed at equal intervals inside the sample inlet tray 6. Each placement seat 711 has a heat-conducting coil 712 fixedly installed inside. These heat-conducting coils 712 have good thermal conductivity and can quickly transfer heat to the sample in the sample dish 714 or absorb heat from the sample. It is particularly noteworthy that the transfer coil 74 is connected in series with each heat-conducting coil 712. The two components are connected in series, which means that the cooling liquid, under the action of the circulating pump 73, can flow through each heat-conducting coil 712 sequentially, ensuring that the sample dish 714 on each placement seat 711 is uniformly cooled. In addition, the main body of the heat-conducting coil 712 is arranged in a spiral manner inside the placement seat 711. This design increases the contact area between the heat-conducting coil 712 and the internal space of the placement seat 711, thereby improving the efficiency of heat conduction. When cooling is required, the cooling liquid can quickly absorb the heat in the sample dish 714. Finally, the inner side of the placement seat 711 is designed with a plug-in structure to facilitate the insertion and removal of the sample dish 714. This design not only simplifies the experimental operation, but also ensures close contact between the sample dish 714 and the heat-conducting coil 712, further improving the heat conduction effect.

[0036] Please refer to Figure 3The displacement mechanism 9 includes a first motor 91 and a slide 92. The slide 92 is formed on both sides inside the concave seat 4. The first motor 91 is fixedly installed at both ends of the concave seat 4 near the guide rail 1. The output end of the first motor 91 passes through the concave seat 4 and is fixedly installed inside the slide 92 with a lead screw 93. The lead screw 93 is rotatably connected to the inside of the slide 92. A slide rod 94 is threadedly connected to the outer surface of the lead screw 93. The slide rod 94 is slidably connected to the inner side of the guide rail 1. The sample feeding plate 6 is fixedly installed inside one of the slide rods 94. The displacement mechanism 9 mainly consists of the first motor 91. The displacement mechanism 9 consists of a slide groove 92, a lead screw 93, and a slide rod 94. The slide groove 92 is formed on both sides of the concave seat 4, creating a stable sliding track. The first motor 91 is fixedly installed at both ends of the concave seat 4 near the guide rail 1, providing power to the displacement mechanism 9. When the first motor 91 starts, its output end passes through the concave seat 4 and enters the interior of the slide groove 92, where the lead screw 93 is fixedly installed. The lead screw 93 is rotatably connected inside the slide groove 92, forming a rotatable drive shaft. The outer surface of the lead screw 93 is designed with threads, which intersect with the threads inside the slide rod 94. The threads are matched, so when the lead screw 93 rotates, the slide bar 94 will move linearly along the lead screw 93 under the action of the thread. This linear motion is constrained by the slide groove 92, ensuring that the slide bar 94 slides smoothly inside the guide rail 1. It is particularly worth mentioning that the sample inlet plate 6 is fixedly installed inside the slide bar 94. This means that when the first motor 91 drives the lead screw 93 to rotate, the slide bar 94 will drive the sample inlet plate 6 to make precise displacement. This design not only realizes the stable movement of the sample inlet plate 6, but also ensures the position of the sample inlet plate 6 during the movement. The precise positioning provides a strong guarantee for the smooth progress of the experiment. In addition, another set of displacement mechanism 9 is used to drive sealing mechanism 8. When the position of injection plate 6 needs to be adjusted, sealing mechanism 8 can move synchronously to ensure that injection plate 6 maintains good sealing performance throughout the experiment. This design not only ensures the reliability of the experiment but also improves work efficiency. The displacement mechanism 9 of the liquid chromatograph temperature control device achieves precise displacement of injection plate 6 and sealing mechanism 8 through the coordinated work of first motor 91, slide groove 92, lead screw 93 and slide bar 94.

[0037] Please refer to Figure 8An annular electric heating plate 715 is fixedly installed at the bottom of the placement base 711, and a temperature sensor 713 is fixedly installed in the middle of the placement base 711. The detection end of the temperature sensor 713 is in close contact with the bottom of the sample dish 714. A microcontroller control module is provided inside the semiconductor cooler 75. The annular electric heating plate 715 fixedly installed at the bottom of the placement base 711 can quickly and evenly heat the sample in the sample dish 714. At the same time, the temperature sensor 713 fixedly installed in the middle of the placement base 711 has its detection end in close contact with the bottom of the sample dish 714 to monitor the temperature change of the sample in real time. This design ensures the accuracy and real-time nature of temperature data, providing a foundation for precise temperature control. More importantly, the semiconductor cooler 75 has a microcontroller control module inside, which intelligently adjusts the working state of the semiconductor cooler 75 based on the real-time data provided by the temperature sensor 713. When cooling is required, the semiconductor cooler 75 starts up quickly, absorbing and removing heat; when heating is required, the annular electric heating plate 715 comes into play, providing a stable heat source. This intelligent temperature control method enables the device to respond quickly to temperature changes and accurately maintain the set temperature.

[0038] Please refer to Figure 5The sealing mechanism 8 includes a side plate 81, which is fixedly installed inside another set of slide rods 94. An electric push rod 82 is fixedly installed at the inner end of the side plate 81. A base frame 83 is fixedly installed at the top of the electric push rod 82. A second motor 84 is fixedly installed inside the base frame 83. A sealing disc 85 is fixedly installed at the top output end of the second motor 84. The sealing mechanism 8 mainly consists of the side plate 81, the electric push rod 82, the base frame 83, the second motor 84, and the sealing disc 85. The side plate 81 is fixedly installed inside another set of slide rods 94, corresponding to the slide rod 94 where the sample inlet plate 6 is located. This design allows the sealing mechanism 8 to move synchronously with the movement of the sample inlet plate 6, ensuring effective sealing of the sample inlet plate 6 throughout the experiment. The electric push rod 82, the main power component of the sealing mechanism 8, can extend and retract as needed, thereby driving the sealing disc 85 closer to or further away from the sample inlet plate 6. The top of the electric push rod 82 is fixedly installed... A base frame 83 provides a stable mounting platform for the second motor 84. The second motor 84 is fixedly mounted on the inner side of the base frame 83. This motor drives the rotation of the sealing disk 85. The sealing disk 85, the core component of the sealing mechanism 8, is fixedly mounted on the top output end of the second motor 84. The sealing disk 85 is made of a material that is resistant to high and low temperatures and corrosion, ensuring a tight fit with the sample inlet disk 6 during the experiment to prevent heat or sample leakage. When the sample inlet disk 6 needs to be sealed, the electric push rod 82 extends, pushing the sealing disk 85 close to the sample inlet disk 6 and making it fit tightly. At the same time, the second motor 84 starts, driving the sealing disk 85 to rotate, ensuring a tighter contact between the sealing disk 85 and the sample inlet disk 6, further improving the sealing effect. This design not only ensures the sealing performance of the sample inlet disk 6 during the experiment but also improves the accuracy and reliability of the experiment. In addition, the synchronous displacement function of the sealing mechanism 8 and the sample inlet disk 6 greatly simplifies the experimental operation and improves work efficiency.

[0039] Please refer to Figure 2The concave seat 4 has a slot 87 on the side near the electric push rod 82. The inner side of the slot 87 is connected to the inside of the slide groove 92. A bracket 88 is fixedly installed on the outer side of the slide rod 94 with a side plate 81. The outer end of the bracket 88 passes through the slot 87 and is rotatably connected to the top of the sealing disc 85 near the electric push rod 82. The slot 87 on the side of the concave seat 4 near the electric push rod 82 is a clever design. This slot 87 not only provides space for the bracket 88 to pass through, allowing the bracket 88 to smoothly connect the sealing disc 85 and the slide rod 94, but it is also connected to the inside of the slide groove 92, ensuring that the movement of the slide rod 94 in the slide groove 92 is not hindered. The bracket 88 fixedly installed on the outer side of the slide rod 94 with a side plate 81 plays a role in connecting the two sides. The bracket 88 serves as a connector and support. Its outer end can pass through the strip groove 87 and rotate to connect with the top of the sealing disc 85 near the electric push rod 82. This connection method allows the sealing disc 85 to smoothly move closer to or away from the sample inlet disc 6 under the push of the electric push rod 82, while ensuring the stability of the sealing disc 85 during rotation. The advantage of this design is that it makes the linkage between the sealing mechanism 8 and the displacement mechanism 9 more compact and efficient. When the slide rod 94 moves under the drive of the lead screw 93, the sealing disc 85 connected through the bracket 88 can move synchronously, realizing real-time sealing of the sample inlet disc 6. At the same time, the sealing disc 85 can also rotate independently when needed to adapt to sample dishes 714 of different shapes and sizes, improving the flexibility and adaptability of sealing.

[0040] Please refer to Figure 5 Sealing plugs 86 are fixedly installed at equal intervals on the bottom of the sealing disk 85. The bottom of each sealing plug 86 is inserted into the upper interior of the sample dish 714. The design of the sealing plugs 86 allows the sealing disk 85 to be tightly inserted into the upper interior of the sample dish 714 when it is in contact with the sample inlet disk 6, forming a complete seal. This design not only prevents heat leakage but also effectively prevents the sample from being contaminated or volatilized during the experiment. Simultaneously, the equal-interval arrangement of the sealing plugs 86 ensures that each sample dish 714 receives uniform sealing pressure, avoiding seal failure caused by uneven pressure. The cloth sealing method not only improves the reliability of the seal but also ensures the accuracy of the experimental results. In addition, the material selection of the sealing plug 86 is also crucial. To ensure its good sealing performance and durability, the sealing plug 86 is usually made of high-temperature resistant and corrosion-resistant materials, which can maintain stable performance during the experiment. The sealing mechanism 8 of the liquid chromatograph temperature control device further enhances the sealing effect through the design of the sealing plug 86, providing researchers with a more stable and reliable experimental environment. This design not only improves the accuracy of the experiment but also extends the service life of the equipment and reduces maintenance costs.

[0041] Please refer to Figure 5The drive mechanism 5 includes a dual-axis motor 51 and a rack 52. The dual-axis motor 51 is fixedly installed inside the fixed frame 3. Drive gears 53 are fixedly installed at both output ends of the dual-axis motor 51. The rack 52 is fixedly installed on both sides of the guide rail 1. The drive gears 53 and the rack 52 are meshed together. The dual-axis motor 51 is fixedly installed inside the fixed frame 3 to ensure its stable working state. The drive gears 53 are fixedly installed at both output ends of the dual-axis motor 51. This design allows the motor to drive the gears on both sides to rotate simultaneously, improving working efficiency. The rack 52 is fixedly installed on both sides of the guide rail 1 and meshes with the drive gears 53. When the dual-axis motor 51 starts, the drive gears 53 will rotate accordingly. Through meshing with the rack 52, the rotational motion of the motor is converted into the linear motion of the guide rail 1. This meshing connection method has the advantages of high transmission efficiency and high positioning accuracy, ensuring the stability and accuracy of the temperature control device during movement.

[0042] Please refer to Figure 3 The overall cross-sectional shape of slider 2 and slider 94 is set as a convex shape. The inner walls of slide groove 92 and guide rail 1 are also set as convex shapes. Wear-resistant pads are fixedly connected to the inner walls of slide groove 92 and guide rail 1. The overall cross-sectional shape of slider 2 and slider 94 is set as a convex shape. This design allows them to better match slide groove 92 and guide rail 1. The convex structure not only provides a larger contact area and increases stability, but also prevents slider 2 and slider 94 from shifting or shaking during movement. The inner walls of slide groove 92 and guide rail 1 are also set as convex shapes, which fit the shape of slider 2 and slider 94, ensuring a tight fit between them. This design allows slider 2 and slider 94 to fit in the slide groove 92 and guide rail 1. The movement within the guide rail 1 is smoother, reducing friction and resistance and improving the transmission efficiency of the entire temperature control device. Furthermore, wear-resistant pads are fixedly connected to the inner walls of both the slide groove 92 and the guide rail 1. These pads are made of materials with excellent wear resistance, effectively reducing wear on the slide groove 92 and guide rail 1 during the movement of the slider 2 and slide rod 94. This not only extends the service life of the temperature control device but also reduces maintenance costs. The structural design of the liquid chromatograph temperature control device, including the slider 2, slide rod 94, slide groove 92, and guide rail 1, fully considers stability and wear resistance. By employing a convex cross-section and wear-resistant pads, the device ensures stable operation over extended periods, providing researchers with reliable and efficient experimental conditions.

[0043] Please refer to Figure 2A support block 54 is slidably connected to the rear side of the guide rail 1. A support rod 55 is fixedly installed on the outer side of the support block 54. The front end of the support rod 55 is rotatably connected to the middle outer side of the drive gear 53. The rear side of the guide rail 1 is designed with a sliding interface to form a sliding connection with the support block 54. This connection method allows the support block 54 to move smoothly on the guide rail 1 while maintaining its fixed position, providing stable support for the drive gear 53. The support rod 55 is fixedly installed on the outer side of the support block 54. This support rod 55 not only plays a connecting and supporting role, but also makes the entire structure more stable. The front end of the support rod 55 is rotatably connected to the middle outer side of the drive gear 53. The design ensures that the drive gear 53 remains stable during rotation, reducing transmission errors caused by vibration or offset. The advantage of this connection method is that it combines the advantages of sliding and rotating connections, ensuring both structural flexibility and transmission accuracy. At the same time, due to the fixed installation of the support block 54 and support rod 55, the entire drive mechanism 5 is more stable during operation, reducing malfunctions caused by structural loosening or deformation. The connection method between the guide rail 1 and the support block 54, support rod 55, and drive gear 53 in this liquid chromatograph temperature control device is ingenious and reasonable, which not only improves the structural stability of the device but also ensures the accuracy and reliability of transmission.

[0044] The implementation principle of the liquid chromatograph temperature control device in this application embodiment is as follows: By setting the temperature control mechanism 7, during use, a sample dish 714 containing a sample can be placed inside the placement seat 711. At this time, the sample dish 714 is inserted into the inner side of the heat-conducting coil 712, and the bottom of the sample dish 714 is in contact with the top of the annular electric heating plate 715. When temperature adjustment is required, if heating is needed, the annular electric heating plate 715 can be directly started. By using the annular electric heating plate 715 in contact with the bottom of the sample dish 714, the annular electric heating plate 715 can be heated quickly. At this time, the temperature sensor 713 contacts the bottom of the sample dish 714 to assist in detecting its temperature change. When the temperature meets the target, the annular electric heating plate 715 is stopped. The device can be operated automatically at step 15. When a rapid temperature reduction is needed, the circulation pump 73 can be activated. The circulation pump 73 drives the water to flow through the transfer coil 74 and each heat-conducting coil 712. The inner side of the heat-conducting coil 712 is in close contact with the sample dish, allowing for rapid heat exchange and transferring heat into the water tank 72. A semiconductor cooler 75 is located at the bottom of the water tank 72. Activating the semiconductor cooler 75 cools the coolant in the water tank 72, aiding in its circulation and heat dissipation. This, in turn, cools the sample dish 714 inside the placement seat 711. This allows the device to rapidly heat and cool the sample tray 6 during use, resulting in overall temperature control and response changes. With its fast operating speed and rapid temperature control, this device significantly improves overall temperature regulation performance. Firstly, it can quickly heat or cool the sample tray 6, greatly enhancing experimental efficiency. When a specific temperature condition needs to be reached rapidly, the annular electric heating plate 715 quickly contacts the bottom of the sample dish 714 for heating, ensuring the sample reaches the required temperature quickly. Simultaneously, the cooling process is equally rapid. A circulating pump 73 drives water to flow in the heat-conducting coil 712, achieving rapid heat exchange with the sample dish 714. A semiconductor cooler 75 further cools the coolant, allowing the sample dish 714 to cool rapidly. This efficient temperature control method greatly shortens experimental preparation time and improves analytical efficiency. Secondly… The device boasts stable and reliable temperature control performance. The close fit between the annular electric heating plate 715 and the bottom of the sample dish 714 ensures uniform heat transfer, avoiding experimental errors caused by temperature gradients. Simultaneously, the temperature sensor 713 monitors the temperature changes of the sample dish 714 in real time, ensuring precise temperature control. During cooling, the coordinated operation of the circulating pump 73 and the semiconductor cooler 75 ensures uniform cooling, preventing uneven temperature distribution within the sample dish 714. Furthermore, the device exhibits strong flexibility and adaptability. By adjusting the power of the annular electric heating plate 715 and the flow rate of the circulating pump 73, precise control of the temperature regulation rate can be achieved, meeting the temperature change requirements of different experiments.The device can also be expanded and upgraded according to experimental needs, such as adding more heat-conducting coils 712 or optimizing the performance of the semiconductor cooler 75 to adapt to more demanding temperature control tasks. Through the temperature control mechanism 7, the device demonstrates advantages in temperature control such as high efficiency, stability, flexibility, and adaptability, providing reliable assurance for experimental analysis.

[0045] By setting up the drive mechanism 5, the device can be operated by starting the dual-axis motor 51 during use. The operation of the dual-axis motor 51 drives the drive gears 53 at both ends to rotate. The rotation of the drive gears 53 engages with the rack 52 for transmission. When the drive gears 53 rotate, the slider 2 slides inside the guide rail 1. The vertical movement of the slider 2 within the guide rail 1 allows for flexible adjustment of the concave seat 4, enabling the entire device to flexibly adjust the sample inlet plate 6 to different heights. Simultaneously, the device can also be operated by starting the first motor 91. The first motor 91 drives the lead screw 93 inside the slide groove 92 to rotate. The lead screw 93 slides back and forth inside the slide groove 92, and the slide rod 94 moves back and forth, thus flexibly adjusting the position of the sample inlet plate 6. Combined with the lifting adjustment of the drive mechanism 5, this allows the sample inlet plate 6 to automatically adjust its position for sample inlet, further improving the adaptability of the device. Firstly, the device achieves flexible adjustment of the sample inlet plate 6's position. By starting the dual-axis motor 51, the drive gear 53 and rack 52 engage to transmit power, causing the slider 2 to slide up and down within the guide rail 1, thereby easily adjusting the height of the concave seat 4 and the sample inlet plate 6. This design allows the sample inlet tray 6 to easily adapt to experimental needs at different heights without manual adjustment, significantly saving experimental preparation time. Secondly, the device also features adjustable forward and backward displacement. By activating the first motor 91, the lead screw 93 slides back and forth within the groove 92, causing the slide rod 94 and sample inlet tray 6 to move forward and backward. This coordinated adjustment of lifting and displacement allows the sample inlet tray 6 to automatically adapt to sample inlet requirements at different positions, further improving the device's adaptability. Furthermore, this design significantly improves the accuracy and efficiency of experimental analysis. Because the position of the sample inlet tray 6 can be precisely adjusted, it can... To ensure the sample is in the optimal position during injection, the accuracy of the analysis is improved. Simultaneously, automated adjustment reduces human error, further enhancing experimental reliability. Finally, this design provides significant convenience for researchers, allowing them to easily adjust the position of the injection plate 6 according to experimental needs without tedious manual operations. This allows them to focus more on the experiment itself, improving work efficiency. Through the driving mechanism 5, this device demonstrates numerous advantages in adjusting the position of the injection plate 6, including flexibility, accuracy, efficiency, and convenience, providing significant assistance to researchers.

[0046] By setting up the sealing mechanism 8, during use, the electric push rod 82 can be activated to push the sealing disc 85 downwards. This allows the sealing disc 85 to move the sealing plug 86 to fill the top of the sample dish 714. The sealing plug 86 at the bottom of the sealing disc 85 also assists the top of the sample dish 714. Since both the sealing mechanism 8 and the temperature control mechanism 7 are installed inside the displacement mechanism, when the displacement of the sample inlet disc 6 needs to be adjusted, the two sets of first motors 91 can be activated. These first motors 91 drive the lead screw 93, causing the slider 2 to move synchronously within the groove 92. This drives the sample inlet disc 6 and the sealing disc 85 to move synchronously, ensuring the stable operation of the sample inlet disc. 6. Simultaneously, during the displacement of the sample injection tray 6, the top is sealed by the sealing disc 85, which further improves the overall sealing performance of the device and prevents sample spillage or cross-contamination inside the sample injection tray 6, maximizing detection accuracy. When it is necessary to open the sample injection tray 6, the sealing disc 85 can be moved upwards by activating the electric push rod 82, causing the sealing disc 85 and sealing plug 86 to move away from the top of the sample dish 714. At this time, the first motor 91 drives the sliding rod 94 to move the sealing disc 85 away, and then the second motor 84 drives the sealing disc 85 to rotate, thus completely dislocating the sealing disc 85 from the top of the sample injection tray 6. This facilitates quick and easy handling of the sample dish 714, making the overall operation of the device more convenient. Furthermore, the sliding period of the sealing disc 85... In the meantime, the sliding rod 94 and the sealing plate 85 can be connected by the bracket 88 sliding inside the strip groove 87, which can further improve the overall stability of the sealing plate 85. First, the device can ensure the sealing of the sample dish 714 during the sample injection process. Driven by the electric push rod 82, the sealing plate 85 and the sealing plug 86 can fit tightly against the top of the sample dish 714, effectively preventing sample spillage and cross-contamination. This is especially important for experiments requiring high-precision analysis, ensuring the accuracy and reliability of experimental results. Second, the device can maintain a sealed state when adjusting the position of the sample injection plate 6. Since the sealing mechanism 8 and the temperature control mechanism 7 are both installed inside the displacement mechanism 9, the sealing remains intact when the height or front-back position of the sample injection plate 6 needs to be adjusted. The sample tray 85 can move synchronously, always maintaining a tight seal against the top of the sample dish 714, ensuring good sealing performance of the sample tray 6 throughout the experiment. This not only prevents sample loss but also improves the reliability and repeatability of the experiment. Furthermore, the device is easy to operate. When it is necessary to open the sample tray 6, simply activate the electric push rod 82 to move the sealing tray 85 and sealing plug 86 upwards, and then drive the sealing tray 85 to move open via a motor. This allows for convenient and quick handling of the sample dish 714. This design greatly simplifies the operation process and improves work efficiency. Finally, the auxiliary connection of the support 88 further enhances the overall stability of the sealing tray 85. During the sliding of the sealing tray 85, the support 88 can slide inside the strip groove 87.Ensuring a secure and reliable connection between the slide rod 94 and the sealing disc 85 prevents seal failure due to vibration or external force. By incorporating the sealing mechanism 8, this device not only boasts excellent sealing performance but also offers convenient, stable, and reliable operation, providing researchers with efficient and accurate experimental conditions and contributing to improved accuracy and reliability of experimental results.

[0047] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A temperature control device for a liquid chromatograph, comprising a guide rail (1), characterized in that: A slider (2) is slidably connected to the inner side of the guide rail (1). A fixed frame (3) is fixedly installed at the outer end of the slider (2). A drive mechanism (5) is fixedly installed on the inner side of the fixed frame (3). A concave seat (4) is fixedly installed on the side of the fixed frame (3) away from the guide rail (1). Displacement mechanisms (9) are fixedly installed on both sides of the concave seat (4). A sample inlet plate (6) is fixedly installed on the inner side of one of the two displacement mechanisms (9). A temperature control mechanism (7) is fixedly installed at the bottom of the sample inlet plate (6). A sealing mechanism (8) is fixedly installed on the inner side of the other displacement mechanism (9). The sealing mechanism (8) covers the top of the sample inlet mechanism. The temperature control mechanism (7) includes a holding component (71) and a water tank (72). The holding component (71) is fixedly installed at equal intervals on the inner side of the sample injection plate (6). The water tank (72) is fixedly installed on one side of the bottom of the sample injection plate (6). A circulation pump (73) is fixedly installed on one side of the water tank (72). The input end of the circulation pump (73) is connected to the water tank (72). A transfer coil (74) is fixedly installed on the output end of the circulation pump (73). The transfer coil (74) is connected to the holding component (71). The output end of the holding component (71) is connected to the inside of the water tank (72). A semiconductor cooler (75) is fixedly installed at the bottom of the water tank (72).

2. The temperature control device for a liquid chromatograph according to claim 1, characterized in that: The holding assembly (71) includes a placement seat (711), which is fixedly installed at equal intervals on the inner side of the sample inlet tray (6). A heat-conducting coil (712) is fixedly installed on the inner side of the placement seat (711). The transfer coil (74) and each heat-conducting coil (712) are connected in series. The main body of the heat-conducting coil (712) is coiled on the inner side of the placement seat (711). A sample dish (714) is inserted into the inner side of the placement seat (711).

3. The temperature control device for a liquid chromatograph according to claim 2, characterized in that: An annular electric heating plate (715) is fixedly installed at the bottom of the placement seat (711), and a temperature sensor (713) is fixedly installed in the middle of the placement seat (711). The detection end of the temperature sensor (713) is attached to the bottom of the sample dish (714), and a single-chip microcomputer control module is provided on the inner side of the semiconductor cooler (75).

4. The temperature control device for a liquid chromatograph according to claim 3, characterized in that: The displacement mechanism (9) includes a first motor (91) and a slide (92). The slide (92) is opened on both sides inside the concave seat (4). The first motor (91) is fixedly installed at both ends of the concave seat (4) near the guide rail (1). The output end of the first motor (91) passes through the concave seat (4) and is fixedly installed inside the slide (92) with a lead screw (93). The lead screw (93) is rotatably connected to the inside of the slide (92). The outer surface of the lead screw (93) is threadedly connected to a slide rod (94). The slide rod (94) is slidably connected to the inner side of the guide rail (1). The sample feeding plate (6) is fixedly installed inside a slide rod (94).

5. The temperature control device for a liquid chromatograph according to claim 4, characterized in that: The sealing mechanism (8) includes a side plate (81), which is fixedly installed on the inner side of another set of slide rods (94). An electric push rod (82) is fixedly installed on the inner end of the side plate (81), and a base frame (83) is fixedly installed on the top of the electric push rod (82). A second motor (84) is fixedly installed on the inner side of the base frame (83), and a sealing disc (85) is fixedly installed on the top output end of the second motor (84).

6. The temperature control device for a liquid chromatograph according to claim 5, characterized in that: The bottom of the sealing plate (85) is fixedly equipped with sealing plugs (86) at equal intervals, and the bottom of each sealing plug (86) is inserted into the upper part of the sample dish (714).

7. A temperature control device for a liquid chromatograph according to claim 5, characterized in that: The concave seat (4) has a strip groove (87) on the side near the electric push rod (82). The inner side of the strip groove (87) is connected to the inside of the slide groove (92). A bracket (88) is fixedly installed on the outer side of the slide rod (94) with side plate (81). The outer end of the bracket (88) passes through the strip groove (87) and is rotatably connected to the top of the sealing plate (85) near the electric push rod (82).

8. A temperature control device for a liquid chromatograph according to claim 7, characterized in that: The overall cross-sectional shape of the slider (2) and the slide rod (94) is set to a convex shape. The inner wall of the slide groove (92) and the guide rail (1) is also set to a convex shape. Wear-resistant pads are fixedly connected to the inner wall of the slide groove (92) and the inner wall of the guide rail (1).

9. A temperature control device for a liquid chromatograph according to claim 1, characterized in that: The drive mechanism (5) includes a dual-axis motor (51) and a rack (52). The dual-axis motor (51) is fixedly installed on the inner side of the fixed frame (3). Drive gears (53) are fixedly installed at both output ends of the dual-axis motor (51). The rack (52) is fixedly installed on both sides of the guide rail (1). The drive gears (53) and the rack (52) are meshed together.

10. A temperature control device for a liquid chromatograph according to claim 9, characterized in that: A support block (54) is slidably connected to the rear side of the guide rail (1), and a support rod (55) is fixedly installed on the outer side of the support block (54). The front end of the support rod (55) is rotatably connected to the middle of the outer side of the drive gear (53).

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