Solid preparation for cleaning

Abstract

The invention provides a solid preparation for cleaning. A solid cleaning preparation for cleaning an oral appliance, which contains (A) a chelating agent, (B) an oxygen-based bleaching agent, and (C) a foaming agent, and optionally contains (D) a sterilizing agent, is prepared. Such a solid preparation for cleaning can be used by being dissolved in water having a hardness of 60-400 mg / L, and has a rapid disintegration property.

Description

Technical Field

[0001] This invention relates to a solid cleaning preparation. More specifically, it relates to a solid cleaning preparation for cleaning intraoral appliances, including dentures, orthodontic retainers, sports braces, and their storage containers. Background Technology

[0002] Oral care is important for improving quality of life and is also useful for the prevention of systemic diseases such as cardiovascular disease and diabetes, which are considered to be associated with periodontal disease.

[0003] For people who wear dentures or frequently use removable retainers after orthodontic treatment, keeping dentures and appliances clean is also related to maintaining oral hygiene and overall health. Keeping dentures and retainers unclean can negatively impact the remaining teeth and periodontal tissues that come into contact with them, potentially leading to tooth decay and periodontal disease.

[0004] Dentures and retainers contain food debris, saliva film (from saliva) on the dentures, tartar, deposits of dental calculus, staining, etc. In contrast, denture care compositions such as food debris adhesion preventers (Patent Document 1) and cleaning agents that act on biofilms have been proposed (Patent Document 2).

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: Japanese Patent Application Publication No. 2018-104345

[0008] Patent Document 2: Japanese Patent Application Publication No. 2021-104937 Summary of the Invention

[0009] Although there are cleaning agents that can remove or prevent dirt from adhering to dentures and retainers, they are sometimes difficult to use effectively due to the hardness of the water used, or sometimes the dissolution in the water takes time, which in turn takes time to clean.

[0010] The purpose of this invention is to provide a solid cleaning preparation that can achieve rapid solubility and excellent cleaning effect when using water with high hardness, which is usually difficult to achieve a cleaning effect, when related instruments are installed in the oral cavity.

[0011] The inventors conducted repeated and in-depth research to solve this problem, and found that by preparing a solid formulation containing an oxygen-based bleaching agent, a specific foaming agent and a chelating agent and having a specified hardness, it is possible to prepare a cleaning agent that exhibits excellent cleaning effect in a short time even when the water used has high hardness, while also having the safety to be compatible with the cleaning of instruments installed in the oral cavity, thus completing the present invention.

[0012] That is, the present invention provides a solid cleaning formulation as described below.

[0013] Item 1.

[0014] A solid cleaning preparation for cleaning oral cavity devices contains (A) a chelating agent, (B) an oxygen bleaching agent, and (C) a foaming agent.

[0015] Item 2.

[0016] The solid dosage form for cleaning according to item 1, wherein the solid dosage form for cleaning is a tablet.

[0017] Item 3.

[0018] The solid cleaning formulation according to claim 1 or 2 further comprises at least one bactericide selected from dichloroisocyanurate, quaternary ammonium salt, isopropyl methylphenol, fluoride, thymol, physalisol and chlorhexidine hydrochloride.

[0019] Item 4.

[0020] A solid cleaning preparation for cleaning oral cavity devices contains (A) a chelating agent, (B) an oxygen bleaching agent and (C) a foaming agent, and dissolves in 150 ml of water with a hardness of 300 mg / L in 0.5 to 10 minutes.

[0021] Item 5.

[0022] According to item 4, the solid cleaning preparation, wherein the above-mentioned component (A) is selected from at least one of alkali metal salts of phosphates, aluminosilicates (zeolites), ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetic acid, tetrasodium ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid and its salts, hydroxyethylethylenediaminetriacetic acid and its salts, and hydroxyethylidene diphosphonic acid (HEDP) and its salts.

[0023] Item 6.

[0024] According to item 4 or 5, the solid cleaning preparation wherein the above-mentioned component (B) is selected from at least one of persulfate, persulfate, percarbonate and perborate.

[0025] Item 7.

[0026] The solid cleaning preparation according to any one of items 4 to 6, wherein the above-mentioned component (C) is a combination of carbonate or bicarbonate with succinic acid, aminosulfonic acid or citric acid.

[0027] Item 8.

[0028] A method for cleaning the oral cavity where related instruments are installed, comprising:

[0029] The process of dissolving a solid cleaning formulation containing (A) a chelating agent, (B) an oxygen-based bleaching agent, and (C) a foaming agent in water with a hardness of 60–400 mg / L; and

[0030] The process of cleaning the oral cavity and installing related instruments in the presence of (A) chelating agent, (B) oxygen bleaching agent, (C) foaming agent and water with a hardness of 60-400 mg / L.

[0031] Item 9.

[0032] A method for sterilizing intraoral appliances includes:

[0033] The process of dissolving a solid cleaning formulation containing (A) a chelating agent, (B) an oxygen-based bleaching agent, and (C) a foaming agent in water with a hardness of 60–400 mg / L; and

[0034] The process of sterilizing intraoral devices in the presence of (A) chelating agent, (B) oxygen bleaching agent, (C) foaming agent and water with a hardness of 60-400 mg / L.

[0035] According to the present invention, a solid preparation for cleaning oral devices that combines cleaning effect and rapid solubility can be provided. Detailed Implementation

[0036] In this specification, salt can be alkali metal salts such as lithium salts, sodium salts, and potassium salts; alkaline earth metal salts such as barium salts; ammonium salts; and their hydrates, etc.

[0037] In this specification, cleaning also includes the removal, sterilization, disinfection, or disinfection of protein-based dirt. Examples of control bacteria in this case include, but are not limited to, *Candida albicans* (a fungus commonly found in the oral cavity), *Streptococcus mutans* (a Gram-positive coccus that is one of the pathogens of dental caries), or *Porphyromonas gingivalis* (a Gram-negative bacillus associated with periodontal disease).

[0038] [Solid preparations for cleaning]

[0039] The solid cleaning formulation of the present invention contains (A) a chelating agent, (B) an oxygen-based bleaching agent, and (C) a foaming agent. It is a solid cleaning formulation that can exert its cleaning effect even when dissolved in water with a hardness of 60–400 mg / L, and is used for cleaning intraoral appliances such as dentures or orthodontic retainers. The water hardness can be high, around 200–400 mg / L.

[0040] (A) Chelating agent)

[0041] The solid cleaning formulation of the present invention contains a chelating agent. Examples of chelating agents include at least one selected from alkali metal salts of phosphoric acid, aluminosilicates (zeolites), ethylenediaminetetraacetic acid (EDTA), disodium EDTA, tetrasodium EDTA, diethylenetriaminepentaacetic acid and its salts, hydroxyethylethylenediaminetriacetic acid and its salts, and hydroxyethylidene diphosphonic acid (HEDP) and its salts. Here, the alkali metal salts of phosphoric acid include alkali metal salts of phosphoric acid, alkali metal salts of pyrophosphate, alkali metal salts of condensed phosphoric acid, and alkali metal salts of metaphosphate. As a preferred component (A), at least one selected from sodium metaphosphate, potassium metaphosphate, sodium polyphosphate, sodium tripolyphosphate, sodium tetrapolyphosphate, sodium pentapolyphosphate, sodium hexametaphosphate, potassium tripolyphosphate, potassium tetrapolyphosphate, potassium pentapolyphosphate, potassium hexametaphosphate, and disodium EDTA. Sodium polyphosphate is more preferably selected from at least one of sodium metaphosphate and disodium EDTA. Alternatively, sodium metaphosphate with the product name Ultraporine (manufactured by Taihei Chemical Co., Ltd.) can be used.

[0042] The content of component (A) relative to the total amount of the solid cleaning formulation of the present invention can vary depending on the mass per unit of the solid cleaning formulation, but from the viewpoint of maximizing the effects of the present invention, it is preferably 0.1% to 25% by mass, more preferably 0.2% to 20% by mass, even more preferably 0.5% to 10% by mass, and particularly preferably 1% to 10% by mass. Component (A) may also be 1% to 20% by mass or 5% to 20% by mass.

[0043] The solid cleaning formulation of the present invention is preferably used in a water-soluble manner. From the viewpoint of maximizing the effects of the present invention, the content of component (A) when used is preferably 0.0001 w / v% to 0.6 w / v, more preferably 0.002 w / v% to 0.5 w / v, even more preferably 0.005 w / v% to 0.4 w / v, even more preferably 0.01 w / v% to 0.3 w / v, and particularly preferably 0.02 w / v% to 0.2 w / v.

[0044] (B) Oxygen-based bleaching agents)

[0045] The solid cleaning formulation of the present invention contains an oxygen-based bleaching agent. Examples of oxygen-based bleaching agents include persulfate, persulfate, percarbonate, or perborate.

[0046] Examples of persulfates include sodium persulfate, potassium persulfate, lithium persulfate, barium persulfate, potassium persulfate monosulfate, and ammonium persulfate.

[0047] Examples of persulfates include sodium persulfate, potassium persulfate, and ammonium persulfate.

[0048] Examples of perborates include sodium perborate, potassium perborate, ammonium perborate, and sodium perborate monohydrate.

[0049] Examples of percarbonates include sodium percarbonate, potassium percarbonate, and ammonium percarbonate.

[0050] As oxygen-based bleaching agents, at least one of them or a combination of two or more can be used.

[0051] As an oxygen-based bleaching agent, an alkali metal salt of persulfate or a complex salt of potassium persulfate, potassium bisulfate, and potassium sulfate is preferred.

[0052] The content of component (B) relative to the total amount of the solid cleaning formulation of the present invention may vary depending on the mass per unit of the solid cleaning formulation, but from the viewpoint of maximizing the effect of the present invention, it is preferred to be 2% to 55% by mass, more preferably 3% to 50% by mass, even more preferably 4% to 40% by mass, even more preferably 5% to 35% by mass, and particularly preferably 6% to 30% by mass.

[0053] The solid cleaning formulation of the present invention is preferably used in a manner that dissolves it in water. From the viewpoint of maximizing the effects of the present invention, the content of component (B) when used is preferably 0.001 w / v% to 1.2 w / v, more preferably 0.005 w / v% to 0.8 w / v, even more preferably 0.01 w / v% to 0.4 w / v, even more preferably 0.02 w / v% to 0.2 w / v, and particularly preferably 0.04 w / v% to 0.1 w / v.

[0054] In the solid cleaning formulation of the present invention, the ratio of component (B) to component (A) is preferably 0.08 parts by mass to 550 parts by mass, more preferably 0.15 parts by mass to 250 parts by mass, even more preferably 0.4 parts by mass to 230 parts by mass, even more preferably 0.8 parts by mass to 220 parts by mass, particularly preferably 1.0 parts by mass to 200 parts by mass, and most preferably 1.5 parts by mass to 20 parts by mass.

[0055] (C) Foaming agent)

[0056] The solid cleaning formulation of the present invention contains a foaming agent. Examples of foaming agents include combinations of carbonates and / or bicarbonates with acids.

[0057] Examples of carbonates and / or bicarbonates include sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, or sodium sesquicarbonate.

[0058] You may use at least one of them or a combination of two or more.

[0059] Sodium carbonate or sodium bicarbonate is preferred as a carbonate and / or bicarbonate.

[0060] Here, acids can be exemplified by organic acids or phosphoric acid, and more specifically, citric acid, succinic acid, sulfamic acid, malic acid, gluconic acid, tartaric acid, maleic acid, sorbic acid, phytic acid, or phosphoric acid, etc.

[0061] You may use at least one of them or a combination of two or more.

[0062] There is no limitation on the acid, but it is preferred to use, for example, citric acid, succinic acid or aminosulfonic acid.

[0063] The ratio of carbonate and / or bicarbonate to acid is not particularly limited, but the acid is preferably 0.3 to 4 parts by mass relative to 1 part by mass of carbonate and / or bicarbonate, more preferably 0.4 to 3.5 parts by mass, and even more preferably 0.5 to 3 parts by mass.

[0064] From the viewpoint of maximizing the effects of the present invention, the content of the foaming agent relative to the total amount of the solid cleaning preparation of the present invention is preferably 30% to 95% by mass, more preferably 40% to 94% by mass, and even more preferably 50% to 92% by mass.

[0065] In the solid cleaning formulation of the present invention, the ratio of component (C) to component (A) is preferably 20 to 99 parts by mass of component (C) to component (A), more preferably 30 to 95 parts by mass, even more preferably 40 to 90 parts by mass, even more preferably 50 to 85 parts by mass, and particularly preferably 60 to 80 parts by mass.

[0066] ((D) component)

[0067] The cleaning solid formulation of the present invention may contain a bactericide (D). Such a bactericide is not limited, but may contain at least one selected from dichloroisocyanurate, quaternary ammonium salts, isopropyl methylphenol, fluorides, thymol, physalisol, and chlorhexidine hydrochloride. Examples of quaternary ammonium salts include, for instance, hexadecylpyridine chloride, benzalkonium chloride, or benzyl chloride.

[0068] As component (D), two or more of them may be used in combination. Although not limited, dichloroisocyanurate and quaternary ammonium salts are preferred, and dichloroisocyanurate, hexadecylpyridine chloride, benzyl chloride or benzalkonium chloride are more preferred.

[0069] The content of component (D) relative to the total amount of the solid cleaning formulation of the present invention may vary depending on the mass of each unit of the solid cleaning formulation, but from the viewpoint of maximizing the effect of the present invention, it is preferred to be 0.1% to 20% by mass, more preferably 0.2% to 10% by mass, and even more preferably 0.3% to 8% by mass.

[0070] The solid cleaning formulation of the present invention is preferably dissolved in water for use. From the viewpoint of maximizing the effect of the present invention, the content of component (D) during use is preferably 0.001 w / v% to 1 w / v, more preferably 0.01 w / v% to 0.5 w / v, and even more preferably 0.1 w / v% to 0.2 w / v.

[0071] (Other ingredients)

[0072] To the extent that it does not impair the effects of the present invention, in addition to the components (A), (B), and (C) described above, any other components may be appropriately incorporated into the solid cleaning formulation of the present invention. These arbitrary components may include surfactants, binders, enzymes, flow improvers, stabilizers, deodorizers, rust inhibitors, fragrances, and / or pigments, etc.

[0073] As a surfactant, any of the following can be used: anionic surfactant, nonionic surfactant, and amphoteric surfactant, with anionic surfactant being particularly preferred.

[0074] Examples of such anionic surfactants include alkylbenzene sulfonates, olefin sulfonates, alkyl sulfonyl acetates, alkyl sulfates, or alkane sulfonates. Among these, alkyl sulfates or olefin sulfonates having an alkyl group having 8 to 16 carbon atoms are particularly preferred, sulfates or olefin sulfonates having a lauryl or myristyl group are more preferred, and sodium lauryl sulfate or sodium olefin sulfonate are even more preferred.

[0075] You may use at least one of them or a combination of two or more.

[0076] Examples of nonionic surfactants include sorbitol fatty acid esters, propylene glycol fatty acid esters, hydrogenated castor oil derivatives, polyoxyethylene sorbitol fatty acid esters, glycerol derivatives, and polyoxyalkylene ethers.

[0077] Examples of amphoteric surfactants include alkyl betaine, fatty acid amyl betaine, alkyl imidazole, lauroyl glutamate, and amine oxide.

[0078] Examples of binders include polyvinylpyrrolidone, polyoxyethylene, polyethylene glycol, carbon wax, sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and cellulose. These binders can be used individually or in combination of two or more.

[0079] You may use at least one of them or a combination of two or more.

[0080] There are no limitations on the binder, but polyethylene glycol or cellulose derivatives with a molecular weight of around 1,000 to 10,000 are preferred.

[0081] Examples of enzymes include proteases, elastinases, amylases, lipases, dextranases, allosteric hydrolases, and glucanases. These enzymes can be used individually or in combination of two or more. Among these, proteases such as papain are preferred.

[0082] Examples of flow improvers (lubricants) include talc, magnesium stearate, magnesium oxide, or talc.

[0083] From the viewpoint of achieving the effects of the present invention, the solid cleaning formulation of the present invention preferably contains substantially no sorbitol or silica, or substantially no one of them. Here, substantially no sorbitol means, except for the case of complete absence, a level of 0.1% by mass or less, preferably 0.01% by mass or less, and more preferably 0.001% by mass or less.

[0084] (pH)

[0085] From the viewpoint of component stability or safety, for example, the solid cleaning formulation of the present invention preferably forms a solution with pH 1 to 9 when 3g is dissolved in 150ml of water and measured at 20°C, and more preferably a solution with pH 1.5 to 8.5. The pH can be measured at 20°C using a commercially available pH meter (e.g., Horiba Manufacturing Co., Ltd., F-52 (registered trademark) type, etc.).

[0086] (Uses, etc.)

[0087] The solid cleaning preparation of the present invention is a solid cleaning preparation for cleaning oral cavity-mounted appliances. Here, oral cavity-mounted appliances refer to dentures, orthodontic retainers, sports braces, and their storage containers, etc.

[0088] The solid cleaning formulation of the present invention is used to dissolve in a solvent such as water and impregnate related instruments placed in the oral cavity with the solution. Impregnation cleans these instruments and also sterilizes them. Here, sterilization refers not only to the complete elimination of bacteria but also to a reduction in their number. The types of bacteria are not limited. Examples of bacteria include facultative anaerobic Gram-positive cocci such as *Streptococcus mutans*, obligate anaerobic Gram-negative bacteria such as *Porphyromonas gingivalis*, and fungi such as *Candida albicans*. The solid cleaning formulation of the present invention is particularly useful for sterilizing fungi such as *Candida albicans*.

[0089] The solid cleaning formulation of the present invention exhibits bactericidal activity even in the absence of a bactericide. For example, there are formulations that do not contain at least one bactericide selected from dichloroisocyanurate, quaternary ammonium salt, isopropyl methylphenol, fluoride, thymol, physalisol, and chlorhexidine hydrochloride, and can still have bactericidal activity against the target bacteria even without these bactericides.

[0090] There are no specific restrictions on the water used at this time, but it can be water with a hardness of about 60 to 400 mg / L, especially water with a hardness of about 200 to 400 mg / L.

[0091] The solid preparation for cleaning of the present invention is not limited and can be provided in tablet or granule form, etc. Tablets are preferred. The shape, weight, and hardness of the tablets are not particularly limited.

[0092] Although the solid cleaning agent of the present invention is not limited, the shape is preferably spherical, cylindrical, ellipsoidal, or polygonal.

[0093] Although the solid cleaning formulation of the present invention is not limited, the weight of each tablet is preferably about 0.5 to 20g, more preferably about 1 to 10g, and even more preferably about 1 to 5g.

[0094] Although the solid cleaning formulation of the present invention is not limited, the diameter of one tablet is preferably about 10 to 60 mm, more preferably 15 to 40 mm.

[0095] The solid cleaning agent of the present invention is not limited, but as for hardness, it is preferred to be about 30 to 400 N, and more preferably about 50 to 200 N, although not limited.

[0096] The solid cleaning formulation of the present invention can be used at a frequency of about 1 to 2 times a day or about once every 2 to 7 days.

[0097] [Instant solubility]

[0098] The preferred dissolution rate of the solid cleaning agent of the present invention in water is, for example, within the range of 0.5 to 10 minutes when 3 g of the solid cleaning agent is dissolved in 150 mL of water (hardness 300 mg / L, water temperature 38°C). This range is preferably 0.7 to 8 minutes, more preferably 0.8 to 7 minutes, even more preferably 0.9 to 6 minutes, and even more preferably 1 to 5 minutes.

[0099] [Cleaning Method]

[0100] A typical cleaning method using the solid cleaning formulation of the present invention may include the following steps: dissolving the tablet-shaped solid cleaning formulation in approximately 50 to 300 mL of water, preferably in approximately 100 to 200 mL of water, and more preferably in approximately 150 mL of water, while immersing a control oral cavity device in the solution, allowing it to stand for 1 to 30 minutes, and then thoroughly rinsing the oral cavity device with water. In cases of severe soiling, the solution may be left to stand overnight before use.

[0101] [Sterilization Method]

[0102] A typical method for sterilization using the solid cleaning formulation of the present invention may include the following steps: dissolving the tablet-shaped solid cleaning formulation in approximately 50-300 mL of water, preferably in approximately 100-200 mL of water, and more preferably in approximately 150 mL of water, while immersing a control oral cavity-mounted device in the solution for 1-30 minutes, and then thoroughly rinsing the oral cavity-mounted device with water. Examples of bacteria targeted for sterilization at this time include facultative anaerobic Gram-positive cocci such as *Streptococcus mutans*, obligate anaerobic Gram-negative bacteria such as *Porphyromonas gingivalis*, and fungi such as *Candida albicans*. The sterilization method of the present invention is particularly useful for sterilizing fungi such as *Candida albicans*.

[0103] Example

[0104] Next, the present invention will be specifically described with reference to embodiments, but the present invention is not limited to the following embodiments. It should be noted that, unless otherwise specified in the table, the units of the component quantities in the table are all mass percentages.

[0105] Tablets of the examples and comparative examples having the compositions shown in Tables 1 and 2 were prepared. Specifically, each component in the table was weighed and mixed by hand. The resulting raw material mixture was compressed into tablets using a mold with a diameter of 20 mm, thereby producing a solid dosage form for denture cleaning with each tablet weighing 3 g and having a hardness of 12 kgf.

[0106] [1] Evaluation test of water dissolution time

[0107] The dissolution time of these tablets in water was evaluated.

[0108] Specifically, the dissolution time was evaluated as follows: One tablet was added to 150 mL of warm water at 38°C, and the time until the tablet was completely dissolved was measured. Water with a hardness of 300 mg / L was used for this process.

[0109] [2] Cleaning effect evaluation test

[0110] The cleaning effect on these tablets was evaluated.

[0111] Specifically, the cleaning effect is evaluated in the following manner.

[0112] Following the JIS K 3370 test method, dentures with simulated dirt were fabricated and cleaned using various cleaning agents. Then, they were rinsed with tap water for 10 seconds, and the degree of dirt removal was visually observed. Complete dirt removal was marked as ◎, partial removal as 〇, slight removal as △, and no removal as ×. Water with a hardness of 300 mg / L was used for this process.

[0113] [Table 1]

[0114]

[0115] In the table, sodium metaphosphate represents the linear compound represented by NanH2PnO3n+1, while sodium polyphosphate refers to the mesh-like structure represented by NaxHy(PO3)(x+y)(X, Y≥1). Here, n is an integer greater than or equal to 14 (although not limited, it is typically around 14 to 30), and x and y represent integers greater than or equal to 1.

[0116] Regarding the results of the evaluation test, the compositions of the examples showed faster disintegration rates and better cleaning effects when using hard water compared to the compositions of the comparative examples.

[0117] [3] Evaluation test of bactericidal effect

[0118] For these tablets, the bactericidal effect (bactericidal power) was evaluated in the following manner.

[0119] (Target bacteria)

[0120] Candida albicans

[0121] (Cultivation medium for bacteria)

[0122] Add lecithin and polysorbate 80 to GP agar medium (glucose peptone agar medium) and use.

[0123] (Preparation method of bacterial culture)

[0124] The formulations of the examples and comparative examples shown in Table 2 were dissolved in 150 mL of purified water. Water with a hardness of 120 mg / L was used. Approximately 0.9 mL of this liquid was added to a test tube to prepare a test sample. 0.1 mL of bacterial suspension was added to the test sample and mixed thoroughly to ensure the target bacteria concentration was approximately 10. 5 ~10 6 cfu / mL. Then store at 25°C, and measure the number of viable bacteria in the test solution after 10 minutes.

[0125] The bacterial count after treatment is divided by the bacterial count before treatment to calculate the bacterial reduction value. The bacterial reduction obtained in this way is evaluated as follows.

[0126] The number of live bacteria is reduced by more than 99%: ◎

[0127] The number of live bacteria is reduced by more than 90% but less than 99%: ○

[0128] The number of live bacteria is reduced by more than 80% but less than 90%: △

[0129] Live bacteria count reduced by less than 80%: ×

[0130] [Table 2]

[0131]

[0132] Regarding the results of the evaluation test, a higher bactericidal effect (sterilization effect) was confirmed in the composition of the examples compared to the composition of the comparative examples. This shows that the bactericidal effect is also higher when using water with high hardness.

Claims

1. A solid cleaning preparation for cleaning oral cavity devices, comprising (A) a chelating agent, (B) an oxygen bleaching agent, and (C) a foaming agent.

2. The solid preparation for cleaning according to claim 1, wherein, The solid preparation for cleaning is a tablet.

3. The solid preparation for cleaning according to claim 1, wherein, It further contains at least one bactericide selected from dichloroisocyanurate, quaternary ammonium salt, isopropyl methylphenol, fluoride, thymol, physalisol and chlorhexidine hydrochloride.

4. A solid preparation for cleaning oral cavity devices, comprising (A) a chelating agent, (B) an oxygen bleaching agent and (C) a foaming agent, dissolving in 150 ml of water with a hardness of 300 mg / L at a dissolution rate of 0.5 to 10 minutes.

5. The solid preparation for cleaning according to claim 4, wherein, The component (A) is selected from at least one of the following: alkali metal salts of phosphates, aluminosilicates (zeolites), ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetic acid, tetrasodium ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid and its salts, hydroxyethylethylenediaminetriacetic acid and its salts, and hydroxyethylidene diphosphonic acid (HEDP) and its salts.

6. The solid cleaning formulation according to claim 4, wherein, The component (B) is selected from at least one of persulfate, persulfate, percarbonate and perborate.

7. The solid preparation for cleaning according to claim 4, wherein, The component (C) is a combination of carbonate or bicarbonate with succinic acid, aminosulfonic acid, or citric acid.

8. A method for cleaning the oral cavity where related instruments are installed, comprising: The process of dissolving a solid cleaning formulation containing (A) a chelating agent, (B) an oxygen-based bleaching agent, and (C) a foaming agent in water with a hardness of 60–400 mg / L; and The process of cleaning the oral cavity with related instruments in the presence of (A) chelating agent, (B) oxygen bleaching agent, (C) foaming agent and water with a hardness of 60-400 mg / L.

9. A method for sterilizing intraoral appliances, comprising: The process of dissolving a solid cleaning formulation containing (A) a chelating agent, (B) an oxygen-based bleaching agent, and (C) a foaming agent in water with a hardness of 60–400 mg / L; and The process of sterilizing intraoral devices in the presence of (A) chelating agent, (B) oxygen bleaching agent, (C) foaming agent and water with a hardness of 60-400 mg / L.

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