Lead-free piezoelectric ceramic atomized mosquito repellent liquid, preparation method thereof and atomizer

Abstract

The invention discloses leadless piezoelectric ceramic atomized mosquito repellent liquid, a preparation method thereof and an atomizer. The mosquito repellent liquid is prepared from the following components: icaridin, a surfactant, an auxiliary material, ethanol and water. According to the mosquito repelling method, the designed lead-free piezoelectric ceramic atomizer is used for efficiently atomizing the solution formed by the icaridin and the auxiliaries, so that the particle size of the administrated medicine is finer, the administrated medicine concentration is smaller, and the mosquito repelling effect is better.

Description

TECHNICAL FIELD

[0001] The present application relates to mosquito repellent, more particularly to a mosquito repellent liquid that can be atomized by a lead-free piezoelectric ceramic atomizer and a preparation method thereof, and a corresponding lead-free piezoelectric ceramic atomizer. BACKGROUND

[0002] Mosquitoes are rampant throughout the year, except in the cold winter. Mosquito bites not only destroy people's happy mood and affect sleep, but also may cause people to contract viruses transmitted by mosquitoes, such as malaria, epidemic encephalitis, dengue fever, and other diseases. In addition, mosquito bites and the resulting itching and inflammation of the skin can affect the appearance of the skin. At present, common mosquito repellent methods include:

[0003] Preventive management: timely clean up garbage and keep clean. Disadvantages: difficult to completely eradicate, suitable for home use, but not suitable for public places.

[0004] Physical isolation: close doors and windows, and use screens and mosquito nets. Disadvantages: cannot completely eliminate, and has location limitations, suitable for home use, but not suitable for public places. Mosquito nets are only suitable for use in bedrooms.

[0005] Chemical mosquito killing and repellent: including mosquito killing products containing pyrethroids. Although the killing effect is significant, the toxicity cannot be ignored, which may have some impact on human health. And the number of consumers who raise pets such as cats and dogs is increasing, and the ability of pets to metabolize or excrete pyrethroid mosquito-killing components is very limited, so they are easily harmed, and the harm is often difficult to reverse. In addition, mosquito repellents such as DEET also have the problems of strong odor, skin irritation, and respiratory tract irritation. Mosquito repellent esters have the disadvantages of short effective time and skin irritation. Although plant essential oils have the advantage of low toxicity, they also have the limitation of relatively weak mosquito repellent effect. The release carriers of these products include mosquito coils, electric heating type mosquito killing tablets, mosquito killing liquid sprays, etc. Traditional mosquito coil mosquito killing products can achieve mosquito killing effect, but also produce a large amount of smoke and dust pollution. The PM2.5 can be as high as five hundred and the PM10 can be as high as seven hundred in one hour of mosquito coil testing. In addition, the burning process produces an unpleasant odor. Other release carriers also have the risk of being inhaled by people in excess and affecting health.

[0006] Ecothopropate, also known as hydroxypiperidine, is a safe, effective and environmentally friendly insect repellent, which has been widely used in developed countries. It does not directly kill insects, but can effectively repel insects by volatilizing the odor of the secretions such as sweat and oil on the human skin, and has very low damage to the health of the user, so that the user can avoid the bites of mosquitoes and insects. It has been proven to be a very effective and non-toxic insect repellent ingredient, and plays an important role in preventing and controlling high-fatal insect-borne diseases such as malaria, dengue fever, hemorrhagic fever, yellow fever, West Nile virus, Lyme disease (Lyme disease), and forest encephalitis. In particular, it is worth noting that ecothopropate has been recommended by the World Health Organization (WHO) as an effective ingredient for preventing diseases such as malaria caused by mosquito bites.

[0007] However, the currently sold mosquito repellent products on the market generally use a solution containing ecothopropate as the effective ingredient, and the administration methods include direct application and pressing the spray head of the medicine bottle to spray. If the administration is excessive, the high viscosity of the effective ingredient ecothopropate will cause the skin to feel greasy and uncomfortable. In addition, the attachment of ecothopropate to the skin surface will also slightly irritate the skin and be absorbed by the skin. Using atomization technology can reduce the release of the administration amount and accurately control the administration, so that the administration is more uniform, the greasy feeling of the skin is reduced, and the harm to the skin and body is further reduced on the basis of the original. However, the current challenge is that the pure ecothopropate or solution has high viscosity and is slightly soluble in water, and existing atomizers are difficult to effectively atomize it. SUMMARY

[0008] To solve the above problems, the present application discloses a mosquito repellent method, a lead-free piezoelectric ceramic atomized mosquito repellent liquid and a preparation method thereof.

[0009] A lead-free piezoelectric ceramic atomized mosquito repellent liquid, the mosquito repellent liquid is composed of the following ingredients: ecothopropate, a surfactant, an auxiliary material, ethanol and water.

[0010] Optionally, the ecothopropate contains various enantiomers and diastereomers; the mass fraction of each component is as follows: ecothopropate 5% to 25%, surfactant 1% to 10%, auxiliary material 1 to 10%, ethanol solvent 20% to 30% and water 50% to 90%; the auxiliary material includes an antioxidant and a perfume, the mass fraction of the antioxidant is 1% to 5%, and the mass fraction of the perfume is 1% to 5%; the antioxidant is Chinese pricklyash seed oil, and the perfume is carvacrol; the surfactant is sodium dodecyl sulfonate.

[0011] A preparation method of mosquito repellent liquid, comprising the following steps: step 1: after water and ethanol solvent are fully mixed, a surfactant is added, stirring is carried out until the surfactant is completely dissolved, and a mixed solution A is obtained; step 2: ecampridine and an antioxidant are added to the mixed solution A obtained in step 1, and stirring is uniformly carried out, so that a mixed solution B is obtained; and step 3: essence and spices are added to the mixed solution B, stirring is uniformly carried out, and the pH value is adjusted to 7-8, so that the mosquito repellent liquid is obtained.

[0012] A mosquito repellent method, wherein the mosquito repellent liquid is filled in a lead-free piezoelectric ceramic atomizer to realize atomization mosquito repellent.

[0013] The application provides a lead-free piezoelectric ceramic atomizer which effectively optimizes the performance and user experience of an electronic atomization device.

[0014] The piezoelectric ceramic micro-porous atomization device comprises a piezoelectric ceramic sheet and a liquid distribution partition plate which are coaxially connected in a stacked manner, and a first through hole is formed in the middle region of the piezoelectric ceramic sheet; the liquid distribution partition plate is located on the side of the piezoelectric ceramic sheet which is axially close to the liquid storage bin, and the liquid distribution partition plate is provided with a plurality of atomization micro-holes for flowing and filling the liquid to be atomized corresponding to the range of the first through hole.

[0015] In the application, the term "flowing and filling" refers to a process in which the liquid to be atomized in the form of molecules or small droplets is driven by surface tension, concentration difference or mechanical movement and realizes directional and continuous transmission through the atomization micro-holes with micron or even nanometer pore diameters.

[0016] In some embodiments of the application, the atomization micro-holes can be cylindrical, and the pore diameter can be 1-10 microns, preferably 6 microns.

[0017] In a preferred embodiment of the application, the atomization micro-holes are conical, the large-diameter end is located on the side close to the liquid storage bin, the inner diameter ranges from 2 to 25 microns, and the small-diameter end is close to the atomization cavity, and the inner diameter ranges from 2 to 6 microns.

[0018] In various embodiments of the present application, the porosity of the distribution partition corresponding to the range of the first through hole can be 20% to 80%.

[0019] In the present application, the "porosity" refers to the ratio of the volume of the pores (atomized micro-holes) in the material to the total volume of the material corresponding to the range of the first through hole of the distribution partition, which is used to reflect the density of the pores in the material. The distribution partition of the present application is provided with a plurality of atomized micro-holes, and the density of these atomized micro-holes is represented by the porosity. The higher the porosity, the greater the flow rate of the liquid to be atomized.

[0020] In various embodiments of the present application, the thickness of the piezoelectric ceramic sheet can be 0.1 to 1 cm, preferably 0.5 to 1 cm.

[0021] In preferred embodiments of the present application, the piezoelectric ceramic sheet is made of lead-free piezoelectric ceramic, preferably potassium sodium niobate (KNN) based lead-free piezoelectric ceramic.

[0022] In preferred embodiments of the present application, the distribution partition is made of metal material, for example, one of stainless steel, copper and copper alloy, aluminum and aluminum alloy, titanium and titanium alloy, magnesium and magnesium alloy, nickel-cobalt alloy, palladium-nickel alloy, etc., preferably stainless steel.

[0023] The present application does not have special limitations on the size of the first through hole formed in the middle region of the piezoelectric ceramic sheet and the proportion of the first through hole on the surface of the piezoelectric ceramic sheet, which can vary in a wide range according to actual needs.

[0024] In various embodiments of the present application, the electric control assembly further comprises an upper electrode and a lower electrode electrically connected with the main board to supply power to the piezoelectric ceramic micro-hole atomization device. In some preferred embodiments of the present application, the upper electrode is arranged between the piezoelectric ceramic micro-hole atomization device and the mist outlet chamber, and a second through hole is opened corresponding to the range of the first through hole; the lower electrode is arranged around the distribution partition in the form of concentric circles.

[0025] In some preferred embodiments of the present application, the mist outlet chamber and the liquid storage bin are connected by threads, and the lower electrode, piezoelectric ceramic micro-hole atomization device and upper electrode are sandwiched therebetween. Preferably, in order to ensure the sealing and stability of the connection part, a silica gel gasket is further arranged between the liquid storage bin and the lower electrode.

[0026] In some preferred embodiments of the present application, the shell is provided with a charging plug interface, which is electrically connected with the main board for charging the battery.

[0027] Preferably, the battery used in the present application is a detachable lithium battery. This can be quickly replaced when needed, reducing the use of the interruption caused by the battery depletion, providing the user with the convenience of continuous use.

[0028] Preferably, the electronic atomizer is designed in the shape of a cylinder or a cuboid with all sharp corners rounded. These shapes have the characteristics of simplicity and beauty in appearance, and meet the ergonomic design.

[0029] Currently marketed mosquito repellent products, such as flower water, mosquito repellent liquid, insecticide and other products have one or several of the following drawbacks: limited mosquito repellent effect, short mosquito repellent time, certain toxicity to humans or pets, poor skin feel, large drug viscosity, and excessive use of drug dosage. The present method solves the above problems by using lead-free piezoelectric ceramic atomization technology to atomize the mosquito repellent liquid.

[0030] Currently marketed mosquito repellent liquid is mainly in the following forms: first, by applying, that is, first pouring an excess of mosquito repellent liquid on the skin surface, and rubbing it evenly with hands; second, spray administration, that is, by pressing the piston rod of the spray bottle, the mosquito repellent liquid is sprayed in mist form under pressure accompanied by high-speed airflow. These methods have one or several of the following obvious drawbacks, such as: the droplets of the generated mist are large, it is difficult to control the accurate dose of administration, the effective ingredient concentration of the used liquid is relatively large, and it is easy to cause the liquid to contact the hands or other skin. The mosquito repellent liquid prepared by the present method is atomized by electricity, which atomizes the mosquito repellent liquid into aerosol with extremely small particle size, reduces the concentration of the effective ingredient of the mosquito repellent liquid, makes the administration more uniform, covers a wider area, and feels warm and not greasy, reducing the irritation and damage to the skin.

[0031] Advantages of atomization technology: the piezoelectric ceramic of the present application does not contain any lead or other toxic heavy metal elements, has the advantages of non-toxic, harmless, low cost, small working noise, controllable atomization amount, etc. By using the high-frequency oscillation of piezoelectric ceramic, the mosquito repellent liquid can be atomized into ultrafine particles of 1-5 microns.

[0032] The advantages of the atomization technology of the present application are:

[0033] (1) Safety. The piezoelectric ceramic atomization chip used in ultrasonic atomization is traditionally made of lead titanate (PZT), which releases heavy metal lead during production, use and disposal, posing a threat to the environment and human health. However, with the increasing demand for environmentally friendly materials, researchers are developing lead-free piezoelectric ceramics, such as lead-free potassium sodium niobate-based piezoelectric ceramics, to reduce the impact on the environment. With the continuous popularization and strengthening of environmental protection, it is inevitable to replace the PZT type with lead-free materials for ultrasonic atomization piezoelectric ceramic atomization chip.

[0034] (2) Product benefit is higher. Due to high volatility of Pb3O4, lead-containing piezoelectric ceramics are generally set up in the suburbs, which has great difficulty in site selection and high transportation cost. The product process is advanced, and no waste harmful to the environment is generated in the processing process. This not only conforms to the policy guidance of national energy conservation and environmental protection, but also significantly reduces the operating cost of enterprises.

[0035] (3) Advantages of mosquito repellent liquid: the prepared mosquito repellent liquid has lower viscosity and is easy to atomize (the comparative example contains an example that is difficult to atomize), improves the skin touch, and is not greasy; the mosquito repellent liquid is atomized by using the atomization method, which can achieve better effect with the same amount, improve the safety of drug use; the prepared mosquito repellent is tested to be safe for human body, and is suitable for sensitive groups such as pregnant women, infants and the elderly, and has no toxic side effects on companion pets such as cats and dogs; the first example of using electrically driven atomization for drug delivery is applied to mosquito repellent products.

[0036] The present application utilizes the lead-free piezoelectric ceramic atomization technology to efficiently atomize the solution of ecarizine and auxiliary ingredients, which can achieve the effects of finer atomized particle size, lower effective ingredient concentration, more uniform drug delivery, and solve the problems of poor skin touch and reduced skin irritation, and further improve the safety. Ecarizine can be used for infants and young children compared with other mosquito repellent products, and will not harm pets. After testing, the product shows little toxic side effects, fully meets the national standards, and achieves mosquito repellent effect comparable to similar products on the market with lower effective ingredient concentration and less amount. After investigation, there is no similar mosquito repellent product on the market that uses lead-free piezoelectric atomization technology for drug delivery. BRIEF DESCRIPTION OF DRAWINGS

[0037] Hereinafter, embodiments of the present application will be described in detail with reference to the accompanying drawings.

[0038] Figure 1 is a structural diagram of one embodiment of the lead-free piezoelectric ceramic atomizer provided by the present application.

[0039] Figure 2 is Figure 1 is a sectional view of the lead-free piezoelectric ceramic atomizer shown in the figure.

[0040] Figure 3 is a structural diagram of the lead-free piezoelectric ceramic microporous atomization device in the lead-free piezoelectric ceramic atomizer provided in the embodiment of the present application. DETAILED DESCRIPTION

[0041] The technical solutions of the present application will be described in detail below through specific embodiments and in conjunction with the drawings. The components or devices in the following experimental examples are general standard components or components known to those skilled in the art unless otherwise specified, and their structure and principle are known to those skilled in the art through technical manuals or through conventional experimental methods.

[0042] The present application provides a mosquito repellent liquid, which can be effectively atomized by a lead-free piezoelectric ceramic atomizer, and achieve ideal mosquito repellent effect by precise control of dosage and uniform administration.

[0043] The mosquito repellent liquid mainly comprises the following components by mass fraction: lcaridin (including various enantiomers and diastereomers) 5-25%, antioxidant 1-5% (auxiliary material), surfactant 1-10%, perfume 1-5% (auxiliary material), ethanol solvent 20-30%, and water 50-90%.

[0044] The mosquito repellent liquid can be atomized by an atomizer, which has a piezoelectric atomizing element. The piezoelectric atomizing element is also widely used in medical devices and household appliances, but most of the piezoelectric atomizing sheets (piezoelectric ceramics) used in the currently marketed atomizing products are made of traditional lead zirconate titanate (PZT) based piezoelectric materials; to make piezoelectric ceramic crystal sheets of specific shapes, it belongs to polycrystalline piezoelectric materials. The thickness is about 0.7mm, and the surface is plated with a silver electrode layer. The main components are lead zirconate titanate 95% and silver electrode 5%. The lead (Pb) element in the lead zirconate titanate (PZT) material is extremely harmful to human health and the ecological environment. According to the test, the lead content in the lead-containing atomizing sheet can reach 2*105 ng / g or more in deionized water at a resonant frequency of 115KHz. The lead (Pb) element in the lead zirconate titanate material is extremely harmful to human health and the ecological environment, and with the improvement of environmental awareness and the implementation of relevant regulations, the piezoelectric ceramics used in ultrasonic atomizers are gradually changing from traditional PZT materials to environmentally friendly lead-free alternatives.

[0045] The present application uses lead-free piezoelectric ceramics as piezoelectric atomizing elements, which do not contain any lead or other toxic heavy metal elements, have the advantages of non-toxicity, low cost, low working noise, controllable atomization amount, etc. By using the high-frequency oscillation of piezoelectric ceramics, the mosquito repellent liquid can be atomized into ultrafine particles of 1-5 microns.

[0046] The present application provides a mosquito repellent method, which is to fill the mosquito repellent liquid into a lead-free piezoelectric ceramic atomizer for atomization mosquito repellent.

[0047] The preparation process of the mosquito repellent liquid of the present application is as follows:

[0048] Step 1: After mixing water and ethanol solvent thoroughly, add surfactant (for example, sodium dodecyl sulfonate), stir to dissolve completely, and obtain mixture A.

[0049] Step 2: Add lcaridin and antioxidant (for example, litsea cubeba seed oil) to the mixture A obtained in step 1, stir uniformly, and obtain mixture B.

[0050] Step 3: Add the essence (e.g., carvacrol) to the mixed solution B, stir until uniform, and measure the pH to be 7-8. If not within the interval, add a pH buffer to adjust the pH to within the interval, and the mosquito repellent is obtained.

[0051] Step 4: Add the prepared mosquito repellent to the assembled atomizer, turn on the switch, and observe the liquid atomization phenomenon.

[0052] Using the above preparation method, the following eight examples of mosquito repellent were prepared:

[0053] Example 1: A mosquito repellent atomized by lead-free piezoelectric ceramic, the mosquito repellent is composed of the following mass fractions of components: ecarazine 5%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 20%, and water 70%.

[0054] Example 2: A mosquito repellent atomized by lead-free piezoelectric ceramic, the mosquito repellent is composed of the following mass fractions of components: ecarazine 10%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 20%, and water 65%.

[0055] Example 3: A mosquito repellent atomized by lead-free piezoelectric ceramic, the mosquito repellent is composed of the following mass fractions of components: ecarazine 15%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 20%, and water 60%.

[0056] Example 4: A mosquito repellent atomized by lead-free piezoelectric ceramic, the mosquito repellent is composed of the following mass fractions of components: ecarazine 20%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 20%, and water 55%.

[0057] Example 5: A mosquito repellent atomized by lead-free piezoelectric ceramic, the mosquito repellent is composed of the following mass fractions of components: ecarazine 5%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 25%, and water 65%.

[0058] Example 6: A mosquito repellent atomized by lead-free piezoelectric ceramic, the mosquito repellent is composed of the following mass fractions of components: ecarazine 10%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 25%, and water 60%.

[0059] Example 7: A mosquito repellent atomized by lead-free piezoelectric ceramic, the mosquito repellent is composed of the following mass fractions of components: ecarazine 15%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 25%, and water 55%.

[0060] Example 8: A mosquito repellent liquid atomized by a lead-free piezoelectric ceramic, the mosquito repellent liquid consists of the following mass fraction of ingredients: Ecamarin 20%, sodium dodecyl sulfonate 3%, carvacol 1%, Litsea cubeba seed oil 1%, ethanol 25%, water 50%.

[0061] The eight examples of mosquito repellent liquid prepared above were added to the assembled lead-free piezoelectric ceramic atomizer, the switch was turned on, and atomization was observed.

[0062] Experimental results

[0063] The above eight examples of mosquito repellent liquid can be successfully atomized (atomization hole diameter d = 6um), and the atomization particle size distribution is as follows:

[0064] Example 1:

[0065]

[0066] Table 1: Atomization particle size distribution of Example 1

[0067] Wherein, Xv55 = 8.379um, Xv65 = 9.899um, particle size d < 3um: 13.713%, particle size d < 5um: 28.954%.

[0068] Example 2:

[0069]

[0070] Table 2: Atomization particle size distribution of Example 2

[0071] Wherein, Xv55 = 7.937um, Xv65 = 9.296um, particle size d < 3um: 13.750%, particle size d < 5um: 30.139%.

[0072] Example 3:

[0073]

[0074] Table 3: Atomization particle size distribution of Example 3

[0075] Wherein, Xv55 = 8.459um, Xv65 = 9.959um, particle size d < 3um: 13.082%, particle size d < 5um: 28.151%.

[0076] Example 4:

[0077]

[0078] Table 4: Atomization particle size distribution of Example 4

[0079] wherein Xv55 = 7.956 um, Xv65 = 9.229 um, particle size d < 3 um: 12.358%, particle size d < 5 um: 28.740%.

[0080] Example 5:

[0081]

[0082] Table 5 Atomized particle size distribution of Example 5

[0083] wherein Xv55 = 8.460 um, Xv65 = 9.952 um, particle size d < 3 um: 12.979%, particle size d < 5 um: 28.047%.

[0084] Example 6:

[0085]

[0086] Table 6 Atomized particle size distribution of Example 6

[0087] wherein Xv55 = 7.949 um, Xv65 = 9.330 um, particle size d < 3 um: 14.000%, particle size d < 5 um: 30.336%.

[0088] Example 7:

[0089]

[0090] Table 7 Atomized particle size distribution of Example 7

[0091] wherein Xv55 = 8.170 um, Xv65 = 9.531 um, particle size d < 3 um: 12.601%, particle size d < 5 um: 28.388%.

[0092] Example 8:

[0093]

[0094] Table 8 Atomized particle size distribution of Example 8

[0095] wherein Xv55 = 8.273 um, Xv65 = 9.669 um, particle size d < 3 um: 12.568%, particle size d < 5 um: 28.087%.

[0096] From the above, the atomized pieces of d = 6 um can be successfully atomized in the above examples, and the atomized particle size distribution is good.

[0097] Experimental results two

[0098] The above eight examples are detected according to GB / T 13917.9-2009 Pesticide Registration Indoor Efficacy Test and Evaluation. Part 9: Repellent, and the test results are as follows:

[0099]

[0100]

[0101] The above examples can achieve good mosquito repellent effect, among which the average effective protection time of examples 1 and 5 is greater than or equal to 4h, which is a class B mosquito repellent product, and the average effective protection time of examples 2, 3, 4, 6, 7 and 8 is greater than or equal to 6h, which is a class A mosquito repellent product.

[0102] Experimental results 3

[0103] The above examples are detected according to GB / T 15670-2017 Pesticide Registration Toxicology Test Method.

[0104] Detection method: one-time limited method, 5000mg / kg percutaneous exposure. Take 10 SD rats, half male and half female, body weight 259.6±10.3(g), evenly apply the test object to the animal back skin exposure area, then cover with a thin adhesive film and porous gauze, fix with non-stimulating adhesive tape, prevent the animal from licking, close contact for 24h, after exposure, use warm water to remove residual test object. Observe the poisoning performance and death of the test animals within 14d after exposure.

[0105] The test results are as follows: example 1:

[0106]

[0107] Example 2:

[0108]

[0109] Example 3:

[0110]

[0111] Example 4:

[0112]

[0113] Example 5:

[0114]

[0115]

[0116] Example 6:

[0117]

[0118] Example 7:

[0119]

[0120] Example 8:

[0121]

[0122] Test: The above examples are all greater than 5000 mg / kg for SD rats acute transdermal LD50, according to the "Pesticide Registration Data Regulations" 3.3.2.8 skin toxicity classification standard, it is micro-toxicity level.

[0123] Comparative Example:

[0124] Comparative Example 1: A mosquito repellent liquid atomized by lead-free piezoelectric ceramic, the mosquito repellent liquid is composed of the following mass fraction of components: icaridin 5%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 15%, water 75%.

[0125] Comparative Example 2: A mosquito repellent liquid atomized by lead-free piezoelectric ceramic, the mosquito repellent liquid is composed of the following mass fraction of components: icaridin 10%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 15%, water 70%.

[0126] Comparative Example 3: A mosquito repellent liquid atomized by lead-free piezoelectric ceramic, the mosquito repellent liquid is composed of the following mass fraction of components: icaridin 15%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 15%, water 65%.

[0127] Comparative Example 4: A mosquito repellent liquid atomized by lead-free piezoelectric ceramic, the mosquito repellent liquid is composed of the following mass fraction of components: icaridin 20%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, ethanol 15%, water 60%.

[0128] Unlike the examples, the system reduces the content of ethanol, the whole solution system presents a non-uniform phase, contains oil substances, it is difficult to sustain atomization, after atomization, there will be oil residues, and it is easy to appear the phenomenon of hole blockage.

[0129] Compare several commonly used alcohol substances in industry:

[0130]

[0131] Toxicity: n-propanol > isopropanol > methanol > ethanol;

[0132] Price: n-propanol > isopropanol > ethanol > methanol;

[0133] Viscosity: isopropanol > n-propanol > ethanol > methanol.

[0134] Considering that methanol is harmful to human body, it is not considered.

[0135] Comparative Example 5: A mosquito repellent liquid atomized by a lead-free piezoelectric ceramic, the mosquito repellent liquid is composed of the following components in mass fraction: ecampridine 10%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, n-propanol 20%, water 65%.

[0136] Comparative Example 6: A mosquito repellent liquid atomized by a lead-free piezoelectric ceramic, the mosquito repellent liquid is composed of the following components in mass fraction: ecampridine 10%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, isopropanol 20%, water 65%.

[0137] The viscosity of the formula prepared by using n-propanol / water and isopropanol / water in Examples 5 and 6 is large, and it is difficult to continuously atomize in the actual measurement process.

[0138] Comparative Example 7: A mosquito repellent liquid atomized by a lead-free piezoelectric ceramic, the mosquito repellent liquid is composed of the following components in mass fraction: ecampridine 10%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, n-propanol 15%, water 70%.

[0139] Comparative Example 8: A mosquito repellent liquid atomized by a lead-free piezoelectric ceramic, the mosquito repellent liquid is composed of the following components in mass fraction: ecampridine 10%, sodium dodecyl sulfonate 3%, carvacrol 1%, Litsea cubeba seed oil 1%, n-propanol 10%, water 75%.

[0140] Considering that the viscosity of n-propanol is large, the content thereof is reduced in Examples 7 and 8, the viscosity of Example 7 is still large, and it is difficult to continuously atomize, and the solution in Example 8 is not uniform, and oily substances are left after atomization, which affects the atomization effect.

[0141] In summary, ethanol / water is selected as the solution, and the content of ethanol is greater than 20%.

[0142] Correspondingly, referring to Figure 1 , Figure 2 and Figure 3 , the application further discloses a lead-free piezoelectric ceramic atomizer which can be used for atomizing the mosquito repellent liquid, and the atomizer comprises a main body 1, a shell 2, an atomization bin 3, a lead-free ceramic micro-porous atomization device 4, a charging socket 5, a switch 6, a circuit board 7, a battery 8, a liquid sucking rod 9, a liquid storage bin 14 and the like. The lead-free piezoelectric ceramic micro-porous atomization device 4 comprises an upper electrode 10, a lead-free piezoelectric ceramic sheet 11, a liquid separation partition plate 12 and a lower electrode 13.

[0143] The main body 1, the shell 2 and the atomization chamber 3 constitute the whole atomizer main body. The main body 1 contains a liquid storage chamber 14, and the main body 1 is tightly connected with the shell 2 by threads, or the main body 1 is connected with the shell 2 by magnetic attraction, and / or the outer walls of the two are provided with clamping grooves, and one or more external clamping shells are used to connect the two. The liquid suction rod 9 penetrates between the main body 1 and the shell 2, and is connected with the lead piezoelectric ceramic microporous atomization device 4. The atomization assembly is integrated with the atomization chamber 3, the lower electrode 10, the lead-free piezoelectric ceramic sheet 11, the liquid distribution partition plate 12 and the lower electrode 13. The connection part of the atomization assembly and the shell 2 is provided with a silica gel gasket.

[0144] The atomization assembly includes the coaxially stacked and connected lead-free piezoelectric ceramic sheet 11 and the liquid distribution partition plate 12. The middle region of the lead-free piezoelectric ceramic sheet 11 forms a first through hole. The liquid distribution partition plate 12 is located on the side of the piezoelectric ceramic sheet close to the liquid storage chamber 14, and the liquid distribution partition plate 12 is provided with a plurality of atomization micropores for flowing the liquid to be atomized corresponding to the range of the first through hole.

[0145] The atomization micropore is cylindrical, and the pore size is 1-10 microns, preferably 6 microns. Alternatively, the atomization micropore is conical, the large diameter end is located on the side close to the liquid storage chamber, the inner diameter is 6-25 microns, the small diameter end is close to the mist outlet cavity, and the inner diameter is 4-6 microns. The porosity of the atomization micropore formed in the piezoelectric ceramic sheet is 20%-80%. The thickness of the piezoelectric ceramic sheet is 0.1-1 cm, preferably 0.5-1 cm. The piezoelectric ceramic sheet is made of lead-free piezoelectric ceramic, preferably potassium sodium niobate (KNN) based lead-free piezoelectric ceramic.

[0146] In use, the atomization liquid is filled into the liquid storage chamber 14 of the main body 1 in advance. In use, the circuit is started by the switch. The switch can select different modes to realize the power-on of one or more atomization ceramic sheets. After the lead-free piezoelectric ceramic sheet 11 is powered on, based on the atomization working principle, the liquid to be atomized reaching the atomization assembly through the liquid suction rod 9 can be continuously atomized, and discharged to the atomization chamber 3.

[0147] Further, the lead-free piezoelectric ceramic sheet 11 is wrapped by the upper electrode 10 and the lower electrode 13, the liquid distribution partition plate 12 is provided with a plurality of atomization micropores, and the liquid in the liquid storage chamber of the main body 1 is atomized and discharged outward through the plurality of atomization micropores.

[0148] Further, the thickness of the lead-free piezoelectric ceramic sheet 11 is about 0.8 cm, the pore size of the atomization micropore on the liquid distribution partition plate 12 is about 6 microns, and the porosity is as high as 80%. After the switch starts the circuit, the lead-free piezoelectric ceramic sheet 11 vibrates at high frequency, the volume of the atomization micropore on the liquid distribution partition plate 12 changes, and then the liquid is squeezed to realize atomization.

[0149] The present application utilizes the lead-free piezoelectric ceramic atomization technology, and the solution formed by mixing ecarizine and adjuvants is high-efficiency atomized, so that the particle size of the aerosol is finer than that of the traditional pressurized spray, the drug administration is more uniform and more precise and controllable, and at the same time, the problems of poor skin touch feeling, further reduction of skin irritation and damage and the like are solved, thereby further improving the safety. Ecarizine can be used for high-sensitive groups such as pregnant women, infants, the elderly and the like, compared with other mosquito repellents, and will not harm pets. The current product test shows that the toxic and side effects are small, completely reach the national standard, and the mosquito repellent effect is effective under the formula of low concentration of active ingredients, and through controllable atomization drug administration, the level of similar products on the market can be reached.

Claims

1. A lead-free piezoelectric ceramic atomizing mosquito repellent liquid, characterized in that, The mosquito repellent liquid contains the following ingredients: icolinergic acid, surfactant, excipients, ethanol and water.

2. The mosquito repellent liquid according to claim 1, characterized in that, The icocaredin comprises various enantiomers and diastereomers.

3. The mosquito repellent liquid according to claim 1, characterized in that, The mass fractions of each component are as follows: icoplanin 5%–25%, surfactant 1%–10%, excipients 1%–10%, ethanol solvent 20%–30%, and water 50%–90%.

4. The mosquito repellent liquid according to claim 3, characterized in that, The excipients include antioxidants and fragrances, wherein the antioxidants have a mass fraction of 1% to 5%, and the fragrances have a mass fraction of 1% to 5%.

5. The mosquito repellent liquid according to claim 4, characterized in that, The antioxidant is Litsea cubeba oil, and the flavoring is carvacrol.

6. The mosquito repellent liquid according to claim 3, characterized in that, The surfactant is sodium dodecyl sulfonate.

7. A method for preparing the mosquito repellent liquid according to any one of claims 1 to 6, characterized in that, Includes the following steps: Step 1: After thoroughly mixing water and ethanol solvent, add surfactant and stir until completely dissolved to obtain mixture A; Step 2: Add icoplanin and antioxidant to the mixture A obtained in Step 1, stir well to obtain mixture B; Step 3: Add fragrance and flavoring to mixture B, stir well, and adjust its pH to 7-8 to obtain the mosquito repellent liquid.

8. A mosquito repellent method, characterized in that, The mosquito repellent liquid described in any one of claims 1 to 6 is loaded into a lead-free piezoelectric ceramic atomizer for atomization and mosquito repellency.

9. A lead-free piezoelectric ceramic atomizer using any one of the mosquito repellent liquids described in claims 1 to 6, characterized in that, The atomizer includes a main body and an outer shell. An atomizing chamber is provided inside the outer shell, and a lead-free ceramic micro-mesh atomizing device is installed in the atomizing chamber. A liquid storage chamber is provided in the main body, and a liquid-absorbing rod passes through the liquid storage chamber and the outer shell of the main body, thereby transporting the mosquito repellent liquid from the liquid storage chamber to the lead-free ceramic micro-mesh atomizing device for atomization.

10. The lead-free piezoelectric ceramic atomizer according to claim 10, characterized in that, The lead-free piezoelectric ceramic microporous atomizing device includes an upper electrode, a lead-free piezoelectric ceramic sheet, a liquid separator, and a lower electrode. The lead-free piezoelectric ceramic sheet is wrapped by two electrode layers, the upper electrode and the lower electrode, and the liquid separator is provided with multiple atomizing micropores.

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