Extraction method of rutin extract for bone-strengthening musk analgesic paste

Abstract

The extraction method is characterized by comprising the following steps: (1) crushing, (2) primary extraction: putting crushed particles into a screen container, then putting the screen container into an extraction tank, adding ethanol into the extraction tank, soaking for 1-2 hours, then opening an interlayer of the extraction tank, heating and refluxing, and extracting for 1-2 hours; a filter screen is arranged at the tank bottom of the extraction tank, a liquid outlet is formed in the bottom end of the extraction tank, a forced reflux pump is connected to the liquid outlet, and liquid medicine in the extraction tank is extracted from the tank bottom and then flows back into the extraction tank from the top of the extraction tank; condensing steam generated by the extraction tank through a reflux condensing pipe, refluxing the steam into the extraction tank, extracting for 1-2 hours, and pumping liquid medicine into a liquid storage tank from a liquid outlet; (3) adding ethanol into the extraction tank, repeating the step of extracting for the first time, and repeatedly extracting for 2-3 times; and (4) combining the extracting solutions, and concentrating to obtain the ruta graveolens extract. The pipeline is prevented from being blocked in the extraction process, stable and autonomous production is achieved, the product yield is stable, the quality consistency is good, the production cost is reduced, and the technological process is simplified.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine technology, in particular to an extraction method of citrus extract for bone-strengthening musk pain-relieving paste. BACKGROUND

[0002] The bone-strengthening musk pain-relieving paste is an external use traditional Chinese medicine patch, which has the effects of dispelling wind and dampness, promoting blood circulation and relieving pain, and is suitable for symptoms such as rheumatic arthralgia, muscle pain and sprain.

[0003] The main component of the paste, the citrus extract, is currently mainly purchased from outside, and there are problems such as quality fluctuation and poor controllability.

[0004] The raw material for preparing the citrus extract, liquidambar resin, is a resin secreted from the plant Liquidambar formosana Hance of Hamamelidaceae, which belongs to a plant natural spice. The liquidambar resin is also a famous traditional Chinese medicine, which has the effects of promoting blood circulation and relieving pain, detoxifying and promoting tissue regeneration, and cooling blood and stopping bleeding. It is used for treating contusion and sprain, carbuncle and swelling pain, hematemesis, epistaxis and external injury bleeding. At present, the extraction method of the citrus extract mainly includes the following steps: cutting the liquidambar resin into pieces, adding ethanol into an extraction tank, and stirring and extracting. The current extraction tank is provided with a heating jacket, can be connected with steam reflux, is provided with a discharge port at the bottom, and is provided with a filter screen at the bottom. After the extraction is completed, the medicinal liquid is discharged, and the drug residue is retained on the filter screen. The top of the extraction tank is provided with a reflux condenser pipe, the steam generated by heating is condensed through the reflux condenser pipe and then returns to the extraction tank, and the top of the extraction tank is provided with a feeding port. However, since the current extraction method is all through mechanical forced stirring to achieve good extraction effect, the stirring blades will further break the soft drug residue in the soaking process, so that the drug residue blocks the filter screen and the pipeline. Therefore, the extraction process becomes complex, stable production cannot be realized, the product quality consistency is poor, and the production cost is reduced. SUMMARY

[0005] In order to solve the above technical problems, the present application provides an extraction method of citrus extract for bone-strengthening musk pain-relieving paste, which avoids the blockage of the pipeline in the extraction process, realizes stable and independent production, has stable product yield, good quality consistency, reduces production cost, and simplifies the process flow.

[0006] In order to achieve the above purposes, the present application is realized by the following technical scheme: an extraction method of citrus extract for bone-strengthening musk pain-relieving paste, characterized by the following steps:

[0007] (1) crushing

[0008] The liquidambar resin is moved into a crushing chamber and crushed into particles by using a coarse crusher for standby use;

[0009] (2) first extraction

[0010] Put the crushed particles into the screen container, then put it into the extraction tank, and add ethanol in the extraction tank, soak for 1-2h, then open the interlayer of the extraction tank, heat and reflux, the bottom of the extraction tank is provided with a filter screen, the bottom end is provided with a liquid outlet, the liquid outlet is connected with a forced reflux pump, the liquid in the extraction tube is pumped out from the tank bottom and then refluxed into the extraction tank from the top of the extraction tank, and the top end of the extraction tank is also provided with a reflux condenser tube, the steam generated by the extraction tank is condensed through the reflux condenser tube and then refluxed into the extraction tank, and the liquid is pumped from the liquid outlet to the liquid storage tank after extraction for 1-2h;

[0011] (3) Add ethanol in the extraction tank again, repeat the steps of the first extraction, and repeat the extraction for 2-3 times;

[0012] (4) Combine the extraction liquid and concentrate to obtain the turmeric extract.

[0013] In the above scheme: in step (1), the toon resin is crushed into 10-18 mesh particles.

[0014] In the above scheme: the mesh of the screen container is 40-60 mesh.

[0015] In the above scheme: during extraction, the amount of ethanol added is 4-5 times the mass of the medicinal material.

[0016] In the above scheme: the mesh of the filter screen is 100 mesh. A finer mesh can prevent soft fine residues from blocking the outlet.

[0017] Beneficial effects: in the present application, the crushed toon resin particles are added to the screen container, the screen container is put into the extraction tank from the feeding port, and the screen container can be multiple, according to the amount of the added medicine, the present application does not need stirring, and uses forced reflux extraction, so that the ethanol is pumped out from the bottom and then reciprocally flows from the drug residue, achieving the extraction effect, reducing the further crushing effect of the stirring blade on the drug residue, avoiding the blockage of the drug residue in the pipeline, improving the production efficiency, simplifying the production process, and finally obtaining the material that can stably reach the quality standard of turmeric extract, with stable yield and good consistency, compared with outsourcing, the production cost is greatly reduced. The inside of the extraction tank does not need to be cleaned, which greatly simplifies the process. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a structural schematic view of the extraction tank of the present application. DETAILED DESCRIPTION

[0019] The present application will be further described below in combination with the drawings and examples.

[0020] Example 1

[0021] A method for extracting turmeric extract for bone-strengthening musk pain-relieving ointment, according to the following steps:

[0022] Crushing

[0023] Put the liquid amber into the crushing room, and use the crusher to crush it into 10-20 mesh particles for later use.

[0024] First extraction

[0025] Put the crushed particles into the screen container 5, which has a mesh size of 40-60 mesh, and a discharge door can be provided. The screen container 5 can also be a cloth bag, and a hanging rope can be provided on the screen container, with the hanging rope located outside the extraction tank, extending from the charging port to the outside of the extraction tank, facilitating the removal of the screen container. Then put it into the extraction tank, and add 4-5 times the amount of ethanol in the extraction tank, soak for 1-2 hours, then open the interlayer of the extraction tank, and use steam heating reflux. The structure of the extraction tank is shown in the prior art, including a tank body 1, and a 100 mesh filter screen 2 is arranged at the bottom of the tank, and a liquid outlet is arranged at the bottom end, and a forced reflux pump 3 is connected to the liquid outlet to extract the liquid from the bottom of the tank, and then reflux into the tank from the top of the tank. A reflux condenser tube 4 is also arranged at the top end of the extraction tank, and the steam generated in the extraction tank is condensed and then refluxed into the extraction tank. A charging port is arranged at the top end of the extraction tank, and the liquid is extracted from the liquid outlet to the liquid tank after 1-2 hours of extraction. The extraction is carried out under normal pressure. Figure 1

[0026] Second extraction: When the first extraction of the liquid is completed, 4 times the amount of 95% ethanol is added to the extraction tank, the interlayer and the steam in the tank are opened for heating, and when the liquid is kept boiling and starts to reflux, the timing is started and the liquid pump is opened for circulation extraction. Extract for 1-2 hours, filter the liquid through a 100 mesh filter after extraction, and then pump it into the liquid tank until it is extracted. The extraction is carried out under normal pressure.

[0027] Third extraction: When the second extraction of the liquid is completed, 4 times the amount of 95% ethanol is added to the extraction tank, the interlayer and the steam in the tank are opened for heating, and when the liquid is kept boiling and starts to reflux, the timing is started and the liquid pump is opened for circulation extraction. Extract for 1-2 hours, filter the liquid through a 100 mesh filter after extraction, and then pump it into the liquid tank until it is extracted. The extraction is carried out under normal pressure.

[0028] Combine the extracted liquid and concentrate to obtain the turmeric extract. The ethanol is recycled. The turmeric extract extracted by the present application can stably meet the quality standards.

[0029]

[0030] ​While embodiments of the application have been shown and described, it is to be understood that the embodiments described are merely exemplary of the principles and application of the present application. Numerous modifications and adaptions can be effected without departing from the spirit and scope of the present application, which is not limited to the exact construction and arrangement described. It is intended, therefore, to cover all modifications and adaptions that fall within the scope of the claims and their equivalents.

Claims

1. A method for the extraction of a rue extract for use in the bone-strengthening musk balm, characterized in that, Extract according to the following steps: (1) crushing The toonak is moved into the crushing room, and a coarse crusher is used to crush it into particles for standby; (2) first extraction The crushed particles are put into a screen container, and then into an extraction tank, and ethanol is added into the extraction tank, soaked for 1-2h, then the interlayer of the extraction tank is opened, heated to reflux, the tank bottom of the extraction tank is provided with a filter screen, the bottom end is provided with a liquid outlet, the liquid outlet is connected with a forced reflux pump, the liquid in the extraction tank is pumped out from the tank bottom, and then refluxed into the extraction tank from the top of the extraction tank, the top end of the extraction tank is also provided with a reflux condenser tube, the steam generated by the extraction tank is condensed through the reflux condenser tube and then refluxed into the extraction tank, and the liquid is pumped from the liquid outlet to the liquid storage tank after extraction for 1-2h; (3) ethanol is added into the extraction tank again, and the steps of the first extraction are repeated, and the extraction is repeated for 2-3 times; (4) the extraction liquid is combined, and the toonak extract is obtained by concentration.

2. The extraction method of the extract of the Rue macerate for the bone-strengthening musk pain-relieving ointment according to claim 1, characterized by: In step (1), the toonak is crushed into 10-18 mesh particles.

3. The extraction method of the extract of the Rue macerate for the bone-strengthening musk pain-relieving ointment according to claim 2, characterized in that: The mesh of the screen container is 40-60 mesh.

4. The extraction method of the rue extract of the bone-strengthening musk pain-relieving ointment according to claim 3, characterized by: When extracting, the amount of ethanol added is 4-5 times the quality of the medicinal material.

5. The extraction method of the extract of the Rubia cordifolia for the bone-strengthening musk pain-relieving ointment according to any one of claims 1-4, characterized in that: The mesh of the filter screen is 100 mesh.

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