Preparation method of pantothenic acid nicotine salt and atomization matrix

Abstract

The invention discloses a preparation method of nicotine pantothenate and an atomization matrix, and the preparation method comprises the following steps: dissolving calcium pantothenate in water, stirring for 0.5-1.5 h, standing for 30-60 min, and filtering out insoluble substances to obtain a calcium pantothenate solution; stirring at the temperature of 25-50 DEG C, dropwise adding nicotine into the calcium pantothenate solution, uniformly mixing, and introducing excessive CO2 gas at the rate of 30-50 ml / min to obtain a mixture A; filtering the mixture A to obtain a solution B, removing at least part of water in the solution B, and filtering the obtained liquid, namely the pantothenic acid nicotine salt; the atomization matrix comprises the pantothenic acid nicotine salt prepared by the preparation method. The preparation method is simple and reliable in process; the atomized matrix has the characteristics of small stimulation, no offensive odor and high safety.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of electronic atomization, and relates to a preparation method of pantothenic acid nicotine salt and an atomization substrate. BACKGROUND

[0002] Smoking is harmful to health, and some products in the prior art replace traditional cigarettes by adding nicotine or nicotine salt. Nicotine salt and free nicotine are generally used, wherein free nicotine has the disadvantage of being too irritating. Since nicotine salt itself has a smoother mouthfeel after being inhaled, nicotine salt atomization substrate can make the satisfaction of smokers closer to that of cigarettes, and the nicotine salt stock solution can last longer without nicotine degradation during storage. The most widely used is benzoic acid nicotine salt, but some countries have begun to ban benzoic acid nicotine salt because benzoic acid may have potential hazards. Other nicotine salts such as acetic acid nicotine salt and lactic acid nicotine salt are also used, but these nicotine salts have the disadvantages of heavy off-flavor, severe pressure fragrance and poor stability. SUMMARY

[0003] The technical problem to be solved by the present application is to provide a novel preparation method of pantothenic acid nicotine salt, which is simple and reliable.

[0004] The further technical problem to be solved by the present application is to provide an atomization substrate, which has the characteristics of low irritation, no off-flavor and high safety.

[0005] The technical solution adopted by the present application to solve the technical problem is: a preparation method of pantothenic acid nicotine salt is constructed, comprising the following steps:

[0006] Dissolve calcium pantothenate in water, stir for 0.5-1.5 h, and let stand for 30-60 min to filter out insoluble substances to obtain a calcium pantothenate solution;

[0007] Stir at a temperature of 25-50 DEG C, add nicotine dropwise to the calcium pantothenate solution, and after mixing, pass excess CO2 gas at a rate of 30-50 ml / min to obtain a mixture A;

[0008] Filter the mixture A to obtain a solution B, remove at least part of the water in the solution B, and filter the obtained liquid, which is the pantothenic acid nicotine salt.

[0009] Further, in the preparation method of the pantothenic acid nicotine salt, the molar ratio of calcium pantothenate to water in the calcium pantothenate solution is preferably 1:120-1:75.

[0010] Further, in the preparation method of the pantothenic acid nicotine salt, the molar ratio of nicotine to calcium pantothenate in the calcium pantothenate solution is preferably 1:1-1:2.

[0011] An atomizing matrix comprising pantothenic acid nicotine salt prepared by the above preparation method.

[0012] Furthermore, the atomizing matrix preferably further includes a matrix solvent and a flavoring agent, wherein the matrix solvent comprises 79-98 parts by weight, the pantothenic acid salt comprises 1-6 parts by weight, and the flavoring agent comprises 1-15 parts by weight.

[0013] Furthermore, in the atomizing matrix, the matrix solvent preferably includes propylene glycol and glycerol, and the weight ratio of propylene glycol to glycerol is 1:2-2:1.

[0014] Furthermore, in the atomizing matrix, the flavoring agent preferably includes at least one of a sweetener, a flavoring agent, and a cooling agent.

[0015] Furthermore, the sweetener in the atomizing matrix preferably includes at least one of neotame, sucralose, steviol glycosides, sorbitol, acesulfame potassium, xylitol, and erythritol.

[0016] Furthermore, in the atomizing matrix, the cooling agent is preferably at least one of WS-23, WS-3, menthol, and menthyl lactate.

[0017] Furthermore, in the atomizing matrix, the fragrance agent preferably includes a fragrance matrix and a fragrance essence. The fragrance matrix includes at least one of maltol, ethyl maltol, vanillin, lactic acid, acetic acid, phenylacetic acid, clove oil, chamomile essential oil, ethyl acetate, ethyl formate, propionic acid, acetic acid, leaf alcohol, eugenol, peach aldehyde, ethyl lactate, sec-butanol, coumarin, olive oil, indole, and rose oil. The fragrance essence includes natural fragrance materials and synthetic fragrances.

[0018] The present invention offers the following advantages: It uses calcium pantothenate and nicotine as raw materials to prepare pantothenate nicotine salt. Calcium pantothenate is readily available and reacts with carbon dioxide to obtain pantothenic acid. Pantothenic acid then reacts with nicotine to yield pantothenate nicotine salt. The entire preparation process is simple, reliable, requires minimal processing conditions, and yields a high output.

[0019] Pantothenic acid nicotine salt is compounded with other materials to form an atomizing matrix. The atomizing matrix has good stability, a smooth taste, no off-flavors, and a pure aroma during combustion or heating. Attached Figure Description

[0020] The present invention will be further described below with reference to the accompanying drawings and embodiments. In the accompanying drawings:

[0021] Figure 1 This is the infrared spectrum of nicotine;

[0022] Figure 2This is the infrared spectrum of Embodiment 1-1 of the present invention. Detailed Implementation

[0023] To provide a clearer understanding of the technical features, objectives, and effects of the present invention, the specific embodiments of the present invention are now described in detail.

[0024] In the following description, specific details, such as particular details, are set forth for illustrative purposes and not for limiting purposes, in order to provide a thorough understanding of the embodiments of the invention. However, it will be apparent to those skilled in the art that the invention may be practiced in other embodiments without these specific details.

[0025] Example 1, a method for preparing pantothenic acid nicotine salt, comprising the following steps:

[0026] S1: Dissolve calcium pantothenate in water, stir for 0.5-1.5 hours, let stand for 30-60 minutes, and filter out the insoluble matter to obtain a calcium pantothenate solution. Calcium pantothenate is a crystalline powder and is easily soluble in water. It can generally be dissolved at room temperature. To improve dissolution, the temperature can be appropriately increased. Therefore, this step preferably uses water heated to 25-50℃, or the solution can be heated to 25-50℃ during the dissolution process. The heating temperature can be selected from 25℃, 28℃, 32℃, 35℃, 40℃, 43℃, 45℃, 48℃, and 50℃. Calcium pantothenate can be dissolved under these temperature conditions. To avoid introducing impurities, distilled water, purified water, or deionized water can be used in this step.

[0027] To ensure complete dissolution, the solution should be stirred for 0.5-1.5 hours. The specific stirring time can be adjusted according to the heating temperature; higher temperatures require shorter stirring times, and lower temperatures require longer stirring times. For example, stirring times of 0.5 hours, 0.7 hours, 1.0 hour, 1.2 hours, 1.4 hours, and 1.5 hours can be used. Calcium pantothenate crystal powder may contain a small amount of impurities. After dissolution, allow the solution to stand to precipitate the insoluble impurities. After precipitation, filter the solution. To ensure complete precipitation of insoluble substances, allow the solution to stand for 30-60 minutes, depending on the actual needs; the standing time can be 30 minutes, 35 minutes, 40 minutes, 45 minutes, 50 minutes, 55 minutes, or 60 minutes.

[0028] In this step, the molar ratio of calcium pantothenate to water is 1:120-1:75. Any ratio within this range is applicable to this invention; for example, ratios such as 1:75, 1:78, 1:80, 1:82, 1:85, 1:88, 1:90, 1:98, 1:100, 1:110, and 1:120 can be selected.

[0029] S2: Add nicotine dropwise to the calcium pantothenate solution at a temperature of 25-50℃ with stirring. After mixing, pass excess CO2 gas at a rate of 30-50 ml / min until the white solid no longer increases, then stop passing the gas to obtain mixture A; mixture A includes solution and precipitate.

[0030] In this step, the reaction raw materials are calcium pantothenate, nicotine, and carbon dioxide. Calcium pantothenate reacts with carbon dioxide to produce pantothenic acid and calcium carbonate. Pantothenic acid reacts with nicotine to produce pantothenic acid salt.

[0031] In this step, the reaction system temperature is 25-50℃. The reaction can proceed normally at any temperature within this range. Therefore, the present invention does not limit the temperature. Temperatures such as 25℃, 28℃, 30℃, 32℃, 35℃, 37℃, 40℃, 43℃, 46℃, 48℃, and 50℃ can be selected, with 40-50℃ being preferred.

[0032] In this step, the molar ratio of nicotine to calcium pantothenate in the calcium pantothenate solution is 1:1 to 1:2. Any ratio within the above range is applicable to this invention.

[0033] The CO2 gas introduction rate is 30-50 ml / min, and this invention is applicable within this range. Specifically, the rates can be 40 ml / min, 30 ml / min, 50 ml / min, 35 ml / min, or 45 ml / min.

[0034] S3: Filter the mixture A to obtain solution B. Remove at least a portion of the water from solution B and filter the resulting liquid, which is pantothenic acid nicotine salt. The white solid precipitated in step S2 is calcium carbonate, which needs to be removed by filtration in this step. Remove the white solid calcium carbonate to obtain solution B.

[0035] Since calcium pantothenate is dissolved using a large amount of water, a large amount of water in solution B needs to be removed. The present invention can remove water by various means such as evaporation and drying, with heating evaporation being preferred. For example, rotary evaporation can be used to remove water, and the water can be evaporated at 100°C. Rotary evaporation can be carried out using a rotary evaporator.

[0036] Solution B also contains insoluble impurities. After filtering out the insoluble impurities, pantothenic acid nicotine salt is finally obtained.

[0037] The following detailed description is provided through specific embodiments:

[0038] Example 1-1, a method for preparing pantothenic acid nicotine salt, comprising the following steps:

[0039] S1. Add 1 mol of calcium pantothenate crystal powder to a clean 3L three-necked flask, add 83.3 mol of distilled water, stir at 25℃ for 1 h to dissolve, let stand for 30 min, filter out the insoluble matter to obtain calcium pantothenate solution.

[0040] S2. At 30℃, add 1 mol of nicotine solution dropwise to a calcium pantothenate solution while stirring. Once the addition is complete and the solution is well mixed, then pass CO2 gas at a rate of 40 ml / min while stirring the solution. A white solid will gradually precipitate out. Pass in excess carbon dioxide until the amount of precipitated white solid no longer increases, then stop the gas flow to obtain mixture A.

[0041] S3. Filter the mixture A to obtain solution B. Dry solution B by rotary evaporation at 100°C to remove all water. Filter the remaining solution again to remove insoluble impurities, yielding pantothenic acid nicotine salt with a yield of 96%. Figure 1 The image shown is the infrared spectrum of nicotine. Figure 2 The infrared spectrum of the final product in this embodiment shows that the product is pantothenic acid nicotine salt.

[0042] Examples 1-2 illustrate a method for preparing pantothenic acid nicotine salt, comprising the following steps:

[0043] S1. Add 1 mol of calcium pantothenate crystal powder to a clean 3L three-necked flask, add 90 mol of distilled water, stir at 50℃ for 1 hour to dissolve, let stand for 30 minutes, and filter out the insoluble matter to obtain calcium pantothenate solution.

[0044] S2. At 25℃, add 2 mol of nicotine solution dropwise to a calcium pantothenate solution while stirring. Once the addition is complete and the solution is well mixed, then pass CO2 gas at a rate of 50 ml / min while stirring the solution. A white solid gradually precipitates out. Continue passing excess carbon dioxide until the precipitated white solid stops increasing, then stop the gas flow to obtain mixture A.

[0045] S3. Filter the mixture A to obtain solution B. Vacuum dry solution B to evaporate the water, leave the solution and filter it again to remove insoluble impurities, to obtain pantothenic acid nicotine salt, with a yield of 98%.

[0046] Examples 1-3 illustrate a method for preparing pantothenic acid nicotine salt, comprising the following steps:

[0047] S1. Add 1 mol of calcium pantothenate crystal powder to a clean 3L three-necked flask, add 100 mol of distilled water, stir at 30℃ for 1 h to dissolve, let stand for 30 min, filter out the insoluble matter to obtain mixture A.

[0048] S2. At 50℃, add 1.5 mol of nicotine solution dropwise to a calcium pantothenate solution while stirring. Once the addition is complete and the solution is well mixed, then pass CO2 gas at a rate of 30 ml / min while stirring the solution. A white solid will gradually precipitate out, and the carbon dioxide will be fully introduced until the amount of precipitated white solid stops increasing. Stop the gas flow to obtain mixture A.

[0049] S3. Filter the mixture A to obtain solution B. Dry solution B by rotary evaporation at 100°C to remove water. Filter the remaining solution again to remove insoluble impurities, and obtain pantothenic acid nicotine salt with a yield of 98%.

[0050] Examples 1-4 illustrate a method for preparing pantothenic acid nicotine salt, comprising the following steps:

[0051] S1. Add 1 mol of calcium pantothenate crystal powder to a clean 3L three-necked flask, add 75 mol of distilled water, stir at 40℃ for 1.2 h to dissolve, let stand for 50 min, filter out the insoluble matter to obtain mixture A.

[0052] S2. At 40℃, 1.2 mol of nicotine solution is added dropwise to a calcium pantothenate solution while stirring. After the addition is complete and the solution is well mixed, CO2 gas is passed through at a rate of 40 ml / min while stirring the solution. A white solid gradually precipitates out, and carbon dioxide is fully introduced until the amount of precipitated white solid no longer increases. Then, the gas is stopped, and mixture A is obtained.

[0053] S3. Filter the mixture A to obtain solution B. Dry solution B by rotary evaporation at 100°C to remove water. Filter the remaining solution again to remove insoluble impurities, and obtain pantothenic acid nicotine salt with a yield of 97.5%.

[0054] Examples 1-5 illustrate a method for preparing pantothenic acid nicotine salt, comprising the following steps:

[0055] S1. Add 1 mol of calcium pantothenate crystal powder to a clean 3L three-necked flask, add 120 mol of distilled water, stir at 40℃ for 1.2 h to dissolve, let stand for 50 min, filter out the insoluble matter to obtain mixture A.

[0056] S2. At 40℃, 1.8 mol of nicotine solution is added dropwise to a calcium pantothenate solution while stirring. After the addition is complete and the solution is well mixed, CO2 gas is introduced at a rate of 35 ml / min while stirring the solution. A white solid gradually precipitates out, and carbon dioxide is fully introduced until the amount of white solid precipitated no longer increases. Then, the gas is introduced and the gas is stopped, yielding mixture A.

[0057] S3. Filter the mixture A to obtain solution B. Dry solution B by rotary evaporation at 100°C to remove water. Filter the remaining solution again to remove insoluble impurities, and obtain pantothenic acid nicotine salt with a yield of 97.7%.

[0058] Example 2: An atomizing matrix comprising pantothenic acid nicotine salt prepared by the method of Example 1. This atomizing matrix can be used in the preparation of e-cigarette liquids, as well as in nicotine pouches, mouth-dissolving films, HNBs, etc.

[0059] In one embodiment, the atomizing matrix further includes a matrix solvent and a flavoring agent, wherein the matrix solvent is in the amount of 79-98 parts by weight, the pantothenic acid salt is in the amount of 1-6 parts by weight, and the flavoring agent is in the amount of 1-15 parts by weight.

[0060] The matrix solvent includes propylene glycol and glycerol, and the weight ratio of propylene glycol to glycerol is 1:2 to 2:1.

[0061] The matrix solvent is the basic substance in the atomization matrix. Glycerol produces a large amount of mist after heating, which is used for atomization of the atomization matrix. However, it has high hygroscopicity and is very viscous. Propylene glycol is a good solvent and diluent that can reduce the viscosity of the atomization matrix and improve its fluidity. Propylene glycol also has good miscibility with flavorings and other flavorings.

[0062] Furthermore, in the atomizing matrix, the flavoring agent preferably includes at least one of a sweetener, a flavoring agent, and a cooling agent. The flavoring agent is used to adjust and improve the taste. The type and amount of flavoring agent can be selected according to needs; for example, only a flavoring agent, a sweetener, or a cooling agent can be added, or two of them can be added, or all three can be added.

[0063] The sweetener preferably includes at least one of neotame, sucralose, steviol glycosides, sorbitol, acesulfame potassium, xylitol, and erythritol.

[0064] The cooling agent is preferably at least one of WS-23, WS-3, menthol, and menthyl lactate, all of which are commercially available products.

[0065] The flavoring agent preferably comprises a flavor matrix and a fragrance, but a fragrance can also be used alone. The flavor matrix includes at least one of maltol, ethyl maltol, vanillin, lactic acid, acetic acid, phenylacetic acid, clove oil, chamomile essential oil, ethyl acetate, ethyl formate, propionic acid, acetic acid, leaf alcohol, eugenol, peach aldehyde, ethyl lactate, sec-butanol, coumarin, olive oil, indole, and rose oil. The fragrance includes natural flavor materials and synthetic fragrances. Natural flavor materials refer to plant and animal materials with various flavors. This invention does not limit the use of natural flavor materials and synthetic fragrances; fragrance materials of various flavors are applicable to this invention. The flavor matrix and fragrance can be selected arbitrarily from the above-mentioned raw materials; this invention does not limit them, and the compounding process can adopt existing technologies.

[0066] The fragrance agent in the following specific embodiments is a fragrance agent that has been combined with a fragrance matrix and a fragrance essence or a fragrance essence with independent components. The fragrance agent can be an existing commercial product, which will not be described in detail here.

[0067] The following detailed description is provided through specific embodiments and comparative examples:

[0068] Examples 2-1 to 2-6 of the present invention are compared one by one with Comparative Examples 1 to 6. The raw material components and their proportions remain unchanged in each set of examples of the present invention and the corresponding comparative examples. Only the type of nicotine salt changes. Examples 2-1 to 2-6 of the present invention use pantothenic acid nicotine salt, while Comparative Examples 1 to 6 use benzoic acid nicotine salt, acetate nicotine salt, lactate nicotine salt, and free nicotine, respectively. The weight parts are the same, and the types and weight parts of the other components are exactly the same.

[0069] Example 2-1: An atomizing matrix comprising the following raw materials in parts by weight:

[0070] Matrix solvents: 40 parts propylene glycol; 45 parts glycerol

[0071] Pantothenic acid nicotine salt: 3 parts

[0072] Neotame sweetener: 2 servings

[0073] Grape flavoring agent: 8 parts

[0074] Cooling agent WS-23: 2 parts

[0075] Comparative Example 1 includes the following raw materials in parts by weight:

[0076] Matrix solvents: 40 parts propylene glycol; 45 parts glycerol

[0077] Nicotine benzoate: 3 parts

[0078] Neotame sweetener: 2 servings

[0079] Grape flavoring agent: 8 parts

[0080] Cooling agent WS-23: 2 parts

[0081] The results of the puffing tests conducted by multiple individuals on Embodiment 2-1 and Comparative Example 1 of the present invention are as follows:

[0082] Example 2-1 Sampling Results

[0083]

[0084] Results of the inhalation of Comparative Example 1

[0085]

[0086] Example 2-2: An atomizing matrix comprising the following raw materials in parts by weight: matrix solvent: 50 parts propylene glycol; 39 parts glycerol

[0087] Pantothenic acid salts: 5 parts

[0088] Sweetener sorbitol: 1 part

[0089] Mint flavoring: 7 parts

[0090] Cooling agent: Menthyl lactate: 3 parts

[0091] Comparative Example 2: Includes the following raw materials in parts by weight:

[0092] Matrix solvents: 50 parts propylene glycol; 39 parts glycerol

[0093] Nicotine benzoate: 5 parts

[0094] Sweetener sorbitol: 1 part

[0095] Mint flavoring: 7 parts

[0096] Cooling agent: Menthyl lactate: 3 parts

[0097] The following are the results of the puffing tests conducted by multiple individuals on Embodiments 2-2 and Comparative Example 2 of the present invention:

[0098] Example 2-2 Sampling Results

[0099]

[0100] Comparative Example 2: Sampling Results

[0101]

[0102]

[0103] Examples 2-3: An atomizing matrix comprising the following raw materials in parts by weight:

[0104] Matrix solvents: 50 parts propylene glycol; 45 parts glycerol

[0105] Pantothenic acid nicotine salt: 4 parts

[0106] Sweetener acesulfame potassium: 5 servings

[0107] Banana flavoring agent: 8 servings

[0108] Cooling agent WS-3: 2 parts

[0109] Comparative Example 3: Includes the following raw materials in parts by weight:

[0110] Matrix solvents: 50 parts propylene glycol; 45 parts glycerol

[0111] Nicotine benzoate: 4 parts.

[0112] Sweetener acesulfame potassium: 5 servings

[0113] Banana flavoring agent: 8 servings

[0114] Cooling agent WS-3: 2 parts

[0115] The following are the results of puffing tests conducted by multiple individuals on Examples 2-3 and Comparative Example 3 of the present invention:

[0116] Sample absorption results of Examples 2-3

[0117]

[0118] Comparative Example 3: Sampling Results

[0119]

[0120] Based on the comparison of the above tasting results, it can be seen that: in terms of throat hit and smoothness, Examples 2-1 to 2-3 of the present invention are superior to Comparative Examples 1, 2, and 3. Regarding off-flavors and impurities, the present invention performs well and has a better taste than that of nicotine benzoate salts. In other words, the overall evaluation of the present invention is superior to that of Comparative Examples 1-3, demonstrating a better taste than that of nicotine benzoate salts.

[0121] Examples 2-4: An atomizing matrix comprising the following raw materials in parts by weight:

[0122] Matrix solvents: 30 parts propylene glycol; 60 parts glycerol

[0123] Pantothenic acid salt: 1 part

[0124] Sweetener sucralose: 1 part

[0125] Orange flavoring agent: 3 parts

[0126] Comparative Example 4 includes the following raw materials in parts by weight:

[0127] Matrix solvents: 30 parts propylene glycol; 60 parts glycerol

[0128] Nicotine acetate: 1 part

[0129] Sweetener sucralose: 1 part

[0130] Orange flavoring agent: 3 parts

[0131] The following are the results of puffing tests conducted by multiple individuals on Examples 2-4 and Comparative Example 4 of the present invention:

[0132] Sample absorption results of Examples 2-4

[0133]

[0134] Results of the inhalation of Comparative Example 4

[0135]

[0136] Examples 2-5: An atomizing matrix comprising the following raw materials in parts by weight:

[0137] Matrix solvents: 50 parts propylene glycol; 48 parts glycerol

[0138] Pantothenic acid nicotine salt: 6 parts

[0139] Mint flavoring agent: 13 parts

[0140] Menthol (a cooling agent): 2 parts

[0141] Comparative Example 5: Includes the following raw materials in parts by weight:

[0142] Matrix solvents: 50 parts propylene glycol; 48 parts glycerol

[0143] Lactate nicotine salts: 6 parts

[0144] Mint flavoring agent: 13 parts

[0145] Menthol (a cooling agent): 2 parts

[0146] The following are the results of puffing tests conducted by multiple individuals on Examples 2-5 and Comparative Example 5 of the present invention:

[0147] Sample absorption results of Examples 2-5

[0148]

[0149] Comparative Example 5: Smoke Result

[0150]

[0151] Examples 2-6: An atomizing matrix comprising the following raw materials in parts by weight:

[0152] Matrix solvents: 60 parts propylene glycol; 30 parts glycerol

[0153] Pantothenic acid nicotine salt: 3 parts

[0154] Sweetener steviol glycosides: 1 part

[0155] Comparative Example 6: Includes the following parts by weight of raw materials:

[0156] Matrix solvents: 60 parts propylene glycol; 30 parts glycerol

[0157] Nicotine: 3 servings

[0158] Sweetener steviol glycosides: 1 part

[0159] The following are the results of puffing tests conducted by multiple individuals on Examples 2-6 and Comparative Example 6 of the present invention:

[0160] Sample absorption results of Examples 2-6

[0161]

[0162]

[0163] Comparative Example 6: Smoke Result

[0164]

[0165] Based on the comparison of the above tasting results, it can be seen that: in terms of throat hit and smoothness, Examples 2-4 to 2-5 of the present invention are superior to Comparative Examples 4 and 5, and Example 2-6 is significantly superior to Comparative Example 6. Regarding off-flavors and impurities, the present invention is significantly superior to Comparative Examples 4, 5, and 6 in terms of the taste of acetate nicotine salt, lactate nicotine salt, and nicotine-based flavorings. In other words, the overall evaluation results of the present invention are superior to those of the comparative examples.

[0166] It is understood that the above embodiments only illustrate preferred embodiments of the present invention, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can freely combine the above technical features without departing from the concept of the present invention, and can also make several modifications and improvements, all of which fall within the protection scope of the present invention. Therefore, all equivalent transformations and modifications made with respect to the scope of the claims of the present invention should fall within the scope of the claims of the present invention.

Claims

1. A method for preparing pantothenic acid nicotine salt, characterized in that, Includes the following steps: Dissolve calcium pantothenate in water, stir for 0.5-1.5 hours, let stand for 30-60 minutes, and filter out the insoluble matter to obtain a calcium pantothenate solution. Stirring at 25-50℃, adding nicotine dropwise to the calcium pantothenate solution, and after mixing, passing excess CO2 gas at a rate of 30-50 ml / min to obtain mixture A; The mixture A is filtered to obtain solution B. At least a portion of the water in solution B is removed and the resulting liquid is pantothenic acid salt.

2. The method for preparing pantothenic acid nicotine salt according to claim 1, characterized in that, The molar ratio of calcium pantothenate to water in the calcium pantothenate solution is 1:120 to 1:

75.

3. The method for preparing pantothenic acid nicotine salt according to claim 1, characterized in that, The molar ratio of nicotine to calcium pantothenate in the calcium pantothenate solution is 1:1 to 1:

2.

4. An atomizing matrix, characterized in that, Including pantothenic acid nicotine salt prepared by the preparation method according to any one of claims 1-3.

5. The atomizing matrix according to claim 4, characterized in that, The atomizing matrix further includes a matrix solvent and a flavoring agent, wherein the matrix solvent comprises 79-98 parts by weight, the pantothenic acid salt comprises 1-6 parts by weight, and the flavoring agent comprises 1-15 parts by weight.

6. The atomizing matrix according to claim 5, characterized in that, The matrix solvent includes propylene glycol and glycerol, and the weight ratio of propylene glycol to glycerol is 1:2 to 2:

1.

7. The atomizing matrix according to claim 5, characterized in that, The flavoring agent includes at least one of sweeteners, flavoring agents, and cooling agents.

8. The atomizing matrix according to claim 7, characterized in that, The sweetener includes at least one of neotame, sucralose, steviol glycosides, sorbitol, acesulfame potassium, xylitol, and erythritol.

9. The atomizing matrix according to claim 7, characterized in that, The cooling agent is at least one of WS-23, WS-3, menthol, and menthyl lactate.

10. The atomizing matrix according to claim 7, characterized in that, The fragrance agent comprises a fragrance matrix and a fragrance essence. The fragrance matrix comprises at least one of maltol, ethyl maltol, vanillin, lactic acid, acetic acid, phenylacetic acid, clove oil, chamomile essential oil, ethyl acetate, ethyl formate, propionic acid, acetic acid, leaf alcohol, eugenol, peach aldehyde, ethyl lactate, sec-butanol, coumarin, olive oil, indole, and rose oil. The fragrance essence comprises natural fragrance materials and synthetic fragrances.

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