Foam type purification disinfectant and disinfection method

Abstract

The foam type purification disinfectant is prepared from the following components in percentage by mass: 0.15 to 0.2 percent of benzalkonium chloride, 10 to 15 percent of a foaming agent, 0.6 to 1.5 percent of alkyl glycoside, 2 to 4 percent of polyvinyl alcohol, 0.7 to 1 percent of nano bentonite and the balance of water, wherein the foaming agent is prepared from short-chain alkyl hydroxyl sulphobetaine with the carbon number of 8 to 12 and long-chain alkyl hydroxyl sulphobetaine with the carbon number of 20 to 24. The components in the foam type purification disinfectant cooperate with one another, so that the foam type purification disinfectant has excellent sterilization and disinfection effects and cleaning effects, and is good in freezing resistance, high in practicability, convenient and rapid.

Description

Technical Field

[0001] This invention relates to the field of disinfectants and disinfection methods, and in particular to a foam-type purifying disinfectant and disinfection method. Background Technology

[0002] Hospital-acquired infections refer to infections acquired within medical institutions. Among the many measures to control hospital-acquired infections, thorough cleaning and disinfection of medical equipment, ward environments, and various supplies are crucial. Experience has shown that effective cleaning and disinfection within hospitals can significantly reduce the incidence of hospital-acquired infections.

[0003] There are many types of disinfectants commonly used on the market, mainly divided into dry powder disinfectants, liquid disinfectants, and foam disinfectants. Foam disinfectants have good adhesion, ensure disinfection time, have good visibility, can clearly distinguish un-disinfected areas, and also have cleaning capabilities. However, many foam disinfectants on the market currently have poor foam stability and lack efficient cleaning and stain removal effects. Moreover, their bactericidal effect is greatly reduced at low temperatures, requiring higher concentrations of disinfectant to solve this problem, which significantly increases costs. Summary of the Invention

[0004] In view of the above situation and in order to overcome the defects of the prior art, the present invention provides a foam-type purifying disinfectant and its preparation method, which at least partially solves the problems in the prior art.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows: A foam-type purifying disinfectant, by mass percentage, comprises: 0.15-0.2% benzalkonium chloride, 10-15% foaming agent, 0.6-1.5% alkyl glycoside, 2-4% polyvinyl alcohol, 0.7-1% nano-bentonite, and the balance being water; wherein, The foaming agent comprises short-chain alkylhydroxysulfonate betaine with 10 to 14 carbon atoms and long-chain alkylhydroxysulfonate betaine with 20 to 24 carbon atoms.

[0006] In a further embodiment, the mass ratio of the short-chain alkylhydroxysulfonate to the long-chain alkylhydroxysulfonate is 7–8.5:1.5–3.

[0007] In a further preferred embodiment, the mass ratio of the short-chain alkylhydroxysulfonate to the long-chain alkylhydroxysulfonate is 8:2.

[0008] In a further embodiment, the alkyl glycoside is selected from any one of octyl xyloside, decyl glucoside, and decyl maltoside.

[0009] In a further embodiment, the mass ratio of the foaming agent to the alkyl glycoside is 10:0.6-1.

[0010] In a further embodiment, the molecular weight of the polyvinyl alcohol is 150,000 to 170,000.

[0011] In a further embodiment, the foam-type purifying disinfectant also contains an auxiliary agent, the mass fraction of which is 0.6% to 1.3%.

[0012] Optionally, the additive is selected from one or a combination of several of sodium salicylate, emulsifier, pH adjuster, and flavoring agent.

[0013] In a further preferred embodiment, the nano-bentonite is further modified with modified starch before use; the modification includes the following steps: (1) Dissolve carboxymethyl starch in water, add initiator, add acrylic acid and N,N-methylenebisacrylamide, react at 70-80℃ for 2-3 hours, wash, dry and pulverize after reaction to obtain modified starch; (2) The nano-bentonite and modified starch are ultrasonically mixed, ultrasonically dispersed in water, and dried to obtain the final product.

[0014] Optionally, in step (1), the mass ratio of carboxymethyl starch, acrylic acid, and N,N-methylenebisacrylamide is 1:1.2 to 2:0.1 to 0.2.

[0015] Optionally, in step (1), the initiator is a peroxide initiator.

[0016] Optionally, in step (2), the mass ratio of the nano-bentonite to the modified starch is 1:0.4 to 0.7.

[0017] The preparation method of the foam-type purification and disinfection agent described above includes the following steps: S1. Mix benzalkonium chloride with 30-50% of the total mass of water to obtain solution I; S2. Mix polyvinyl alcohol, sodium salicylate, nano-bentonite, and the remaining water to obtain solution II; S3. Mix solution I and solution II, add foaming agent, alkyl glycoside and auxiliary agent to obtain foam-type purification and disinfection agent.

[0018] The present invention also provides a disinfection method, which includes disinfection using the foam-type purifying disinfectant described above.

[0019] In a further preferred embodiment, the disinfection method includes the following steps: diluting the foam-type purifying disinfectant with water, and then using a foaming spray gun to spray it evenly at a distance of 2-3m from the object to be disinfected, so that a layer of disinfectant foam is evenly attached to the surface of the object to be disinfected. After 10-30 minutes, it can be rinsed with water.

[0020] Compared with the prior art, the present invention has the following beneficial effects: This invention provides a foam-type purifying disinfectant and disinfection method, which combines excellent bactericidal and disinfection effects with cleaning properties, and has good freeze resistance. It is suitable for cleaning and disinfecting hospital medical equipment, ward environments, and various supplies, and is highly practical, convenient, and quick. The addition of a foaming agent and alkyl glycosides makes the foam disinfectant produce rich foam that is not easily defoamed and has strong adhesion, thereby helping to extend the disinfection time and also providing a synergistic bactericidal effect. Detailed Implementation

[0021] The following non-limiting embodiments are intended to enable those skilled in the art to gain a more comprehensive understanding of the present invention, but do not limit the invention in any way. The following description is merely an exemplary illustration of the scope of protection of the present invention, and those skilled in the art can make various changes and modifications to the invention based on the disclosed content, which should also fall within the scope of protection of the present invention.

[0022] Proper cleaning and disinfection of medical equipment, ward environments, and various supplies can significantly reduce the incidence of hospital-acquired infections. Commonly used disinfectants include dry powder disinfectants, liquid disinfectants, and foam disinfectants. Foam disinfectants have good adhesion, ensure sufficient disinfection time, offer good visibility allowing for clear identification of unsterilized areas, and also possess cleaning capabilities. However, many foam disinfectants on the market currently have short foam half-lives and lack highly effective cleaning and stain removal properties. Their bactericidal effect is greatly reduced at low temperatures, requiring higher concentrations to address this issue, which significantly increases costs.

[0023] This invention uses benzalkonium chloride, a quaternary ammonium salt disinfectant, and adds foaming agents, alkyl glycosides, etc. to work synergistically with the disinfectant, giving it strong bactericidal and disinfecting ability, good adhesion, ensuring disinfection time, good cleaning ability, good antifreeze properties, and expanding its applicable range.

[0024] To address the aforementioned problems, this invention provides a foam-type purification and disinfection agent, comprising, by mass percentage: 0.15-0.2% benzalkonium chloride, 10-15% foaming agent, 0.6-1.5% alkyl glycoside, 2-4% polyvinyl alcohol, 0.7-1% nano-bentonite, 0.6-1.3% additives, with the balance being water; wherein, The foaming agent comprises short-chain alkylhydroxysulfonate betaine with 10 to 14 carbon atoms and long-chain alkylhydroxysulfonate betaine with 20 to 24 carbon atoms.

[0025] In a further embodiment, the mass ratio of the short-chain alkylhydroxysulfonate to the long-chain alkylhydroxysulfonate is 7-8.5:1.5-3, preferably 8:2.

[0026] In a further embodiment, the alkyl glycoside is selected from any one of octyl xyloside, decyl glucoside, and decyl maltoside.

[0027] In a further embodiment, the mass ratio of the foaming agent to the alkyl glycoside is 10:0.6-1.

[0028] In actual production, the carbon chain length of the foaming agent has a significant impact on the surfactant. While short-chain alkyl hydroxysulfonate betaines foam quickly, they have poor foam stability, while long-chain alkyl hydroxysulfonate betaines foam slowly but have good foam stability. This invention combines two foaming agents with different chain segments of alkyl hydroxysulfonate betaines in a certain proportion in a disinfectant. The two exhibit a synergistic effect, ensuring good foaming performance and improving foam stability. Adding a certain amount of alkyl glycosides, working together with the foaming agent, results in rich foam that is less prone to defoaming and has strong adhesion, thus helping to extend the disinfection time. The combined effect of alkyl glycosides and foaming agents also helps to compensate for the low-temperature crystallization problem of glutaraldehyde and quaternary ammonium salt disinfectants when used together, improving low-temperature stability and enhancing cleaning effectiveness.

[0029] It should be noted that the alkylhydroxysulfonate betaine of the present invention can be purchased directly or prepared according to existing technology, and there are no special limitations. In a specific embodiment of the present invention, the alkylhydroxysulfonate betaine is prepared from a corresponding alkyl tertiary amine and sodium 2-hydroxy-3-chloropropanesulfonate as raw materials. The alkylhydroxysulfonate betaine can also be prepared by other methods, which do not constitute a limitation of this application.

[0030] The main component of the disinfectant of this invention is benzalkonium chloride, a quaternary ammonium salt disinfectant. It is non-irritating to the skin, non-corrosive, and has strong surface activity, giving the disinfectant a strong bactericidal and disinfecting ability. It can kill pathogenic microorganisms in the environment, thereby cutting off the spread of pathogens.

[0031] In a further embodiment, the molecular weight of the polyvinyl alcohol is 150,000 to 170,000.

[0032] This invention adds polyvinyl alcohol of a certain molecular weight to the disinfectant, which can enhance the viscosity of the foam liquid film and further enhance the stability of the foam, thereby ensuring that the disinfectant can better exert its disinfection and cleaning effect.

[0033] In a further embodiment, the adjuvant includes, but is not limited to, any one or a combination of sodium salicylate, pH adjuster, and flavoring agent.

[0034] In a further preferred embodiment, the nano-bentonite is further modified with modified starch before use; the modification includes the following steps: (1) Dissolve carboxymethyl starch in water, add initiator, add acrylic acid and N,N-methylenebisacrylamide, react at 70-80℃ for 2-3 hours, wash, dry and pulverize after reaction to obtain modified starch; (2) The nano-bentonite and modified starch are ultrasonically mixed, ultrasonically dispersed in water, and dried to obtain the final product.

[0035] Optionally, in step (1), the mass ratio of carboxymethyl starch, acrylic acid, and N,N-methylenebisacrylamide is 1:1.2 to 2:0.1 to 0.2.

[0036] Optionally, in step (1), the mass ratio of the nano-bentonite to the modified starch is 1:0.4 to 0.7.

[0037] Optionally, in step (1), the initiator is a peroxide initiator.

[0038] The disinfectant of this invention incorporates nano-bentonite, which has a good deodorizing effect. The nano-bentonite, after modification, can act as a foam stabilizer. It interacts with the foaming agent to increase the viscosity of the foam system, improve foam stability, extend disinfection time, and also help improve low-temperature resistance. This helps overcome the problem that the disinfectant's performance deteriorates in low-temperature environments and requires a larger dosage to achieve the desired disinfection effect, thereby reducing costs and broadening its applicability.

[0039] This invention also provides a method for preparing the foam-type purification and disinfection agent described above, comprising the following steps: S1. Mix benzalkonium chloride with 30-50% of the total mass of water to obtain solution I; S2. Mix polyvinyl alcohol, sodium salicylate, nano-bentonite, and the remaining water to obtain solution II; S3. Mix solution I and solution II, add foaming agent, alkyl glycoside and auxiliary agent to obtain foam-type purification and disinfection agent.

[0040] The present invention also provides a disinfection method, which includes disinfection using the foam-type purifying disinfectant described above.

[0041] In a further embodiment, the disinfection method includes the following steps: diluting the foam-type purifying disinfectant with water, and then using a foaming spray gun to spray it evenly at a distance of 2 to 3 meters from the object to be disinfected, so that a layer of disinfectant foam is evenly attached to the surface of the object to be disinfected, and rinsing with water after 10 to 30 minutes.

[0042] The present invention will be further described below by way of specific embodiments. Unless otherwise specified, all chemical reagents used in the embodiments of the present invention are obtained through conventional commercial means.

[0043] Example 1 A foam-type purifying disinfectant, by mass percentage, comprises: 0.15% benzalkonium chloride, 10% foaming agent, 0.6% octyl xylosin, 1% polyvinyl alcohol (molecular weight 150,000), 0.5% sodium salicylate, 1% nano-bentonite, pH adjuster, and the balance being water. The foaming agent is tetradecyl hydroxysulfonate and tetradecyl hydroxysulfonate in a mass ratio of 7:3.

[0044] The preparation method of the above-mentioned foam-type purification and disinfection agent includes the following steps: S1. Mix benzalkonium chloride with 30% of the total mass of water to obtain solution I; S2. Mix polyvinyl alcohol, sodium salicylate, nano-bentonite, and the remaining water to obtain solution II; S3. Mix solution I and solution II, add foaming agent and octyl xyloside, and add pH adjuster to adjust pH to about 6.5 to obtain foam-type purification and disinfection agent.

[0045] Example 2 A foam-type purifying disinfectant, by mass percentage, comprises: 0.2% benzalkonium chloride, 15% foaming agent, 1.5% decyl glucoside, 3% polyvinyl alcohol (molecular weight 170,000), 1% sodium salicylate, 1.5% nano-bentonite, 0.3% pH adjuster, with the balance being water. The foaming agent is dodecyl hydroxysulfonate and eicosyl hydroxysulfonate in a mass ratio of 8:2.

[0046] The preparation method of the above-mentioned foam-type purification and disinfection agent includes the following steps: S1. Mix benzalkonium chloride with 50% of the total mass of water to obtain solution I; S2. Mix polyvinyl alcohol, sodium salicylate, nano-bentonite, and the remaining water to obtain solution II; S3. Mix solution I and solution II, add foaming agent and decyl glucoside, and add pH adjuster to adjust pH to about 6.5 to obtain foam-type purification and disinfection agent.

[0047] Example 3 A foam-type purifying disinfectant, by mass percentage, comprises: 0.2% decyl bromide, 15% foaming agent, 1.5% decyl glucoside, 3% polyvinyl alcohol (molecular weight 170,000), 1% sodium salicylate, 1.5% nano-bentonite, 0.3% pH adjuster, with the balance being water.

[0048] The foaming agents are decyl hydroxysulfonate and eicosyl hydroxysulfonate in a mass ratio of 8.5:1.5.

[0049] The preparation method of the above-mentioned foam-type purification and disinfection agent includes the following steps: S1. Mix decyl ammonium bromide with 50% of the total mass of water to obtain solution I; S2. Mix polyvinyl alcohol, sodium salicylate, nano-bentonite, and the remaining water to obtain solution II; S3. Mix solution I and solution II, add foaming agent and decyl glucoside, and add pH adjuster to adjust pH to about 6.5 to obtain foam-type purification and disinfection agent.

[0050] Example 4 The difference from Example 2 is that the foaming agent is dodecyl hydroxysulfonate and eicosyl hydroxysulfonate in a mass ratio of 6:4.

[0051] Example 5 The difference from Example 2 is that the foaming agent is dodecyl hydroxysulfonate and eicosyl hydroxysulfonate in a mass ratio of 9:1.

[0052] Example 6 The difference from Example 2 is that the foam-type purifying disinfectant contains 10% foaming agent and 0.5% decyl glucoside by mass.

[0053] Example 7 The difference from Example 2 is that the foam-type purification disinfectant contains 10% foaming agent and 2% decyl glucoside by mass.

[0054] Example 8 The difference from Example 2 is that the nano-bentonite is modified with modified starch before use. The modification method includes the following steps: Dissolve 10 parts of carboxymethyl starch in sufficient water, add 0.05 parts of initiator, 12 parts of acrylic acid, and 1 part of N,N-methylenebisacrylamide. React at 70°C for 3 hours. After the reaction is complete, wash, dry, and pulverize to obtain modified starch. Mix nano-bentonite and modified starch at a mass ratio of 1:0.4, add to water, ultrasonically disperse, and dry to obtain the final product.

[0055] Example 9 The difference from Example 8 is that the modification method of nano-swelling includes the following steps: Dissolve 10 parts of carboxymethyl starch in sufficient water, add nano-bentonite and modified starch at a mass ratio of 1:0.4, mix ultrasonically, and dry to obtain the final product.

[0056] Comparative Example 1 The difference from Example 2 is that the short-chain alkyl hydroxy sulfonate betaine is octyl hydroxy sulfonate betaine, and the long-chain alkyl hydroxy sulfonate betaine is hexadecyl hydroxy sulfonate betaine.

[0057] Comparative Example 2 The difference from Example 2 is that the foaming agent is only dodecyl hydroxysulfonate betaine.

[0058] Comparative Example 3 The difference from Example 2 is that the foaming agent is only eicosylhydroxysulfonate. Comparative Example 4 The difference from Example 2 is that decyl glucoside is not added.

[0059] Comparative Example 5 The difference from Example 2 is that polyvinyl alcohol is not added.

[0060] Test Example 1 Disinfection performance test The bactericidal performance was determined in accordance with GB4789.2-2016 "National Standard of the People's Republic of China for Food Hygiene Microbiology Examination: Determination of Total Colony Count". The test strains were Escherichia coli and Staphylococcus aureus, and the bactericidal rate after 10 minutes of action was recorded.

[0061] Tests showed that the foam-type purifying disinfectants prepared in each embodiment and comparative example exhibited excellent disinfection performance, with a sterilization rate of over 99%, capable of killing almost all test bacteria, demonstrating good sterilization and disinfection performance.

[0062] Test Example 2 Foaming stability test Using foaming spray guns of the same specifications, the foam-type purifying disinfectants prepared in the examples and comparative examples were sprayed, and the foam residence time was examined. The evaluation criteria were based on the "Determination of Foaming Power - Modified Ross-Miles Method" in the national standard. The results are shown in Table 1 below.

[0063] Table 1

[0064] The results showed that the disinfectant obtained in the embodiments of the present invention had a foam residence time of more than 28 minutes, exhibiting long foam residence time, high foam stability, and long effective disinfection time. Compared with Embodiment 2, the changes in the proportion of foaming agent and the proportion with decyl glucoside in Embodiments 4 to 7 significantly shortened the foam residence time. Adding only one foaming agent or not adding decyl glucoside also resulted in a significant reduction in foam residence time. Therefore, selecting foaming agents with two chain segments, or combining foaming agents with alkyl glycosides, helps to improve the foam stability of the disinfectant and extend the effective disinfection time.

[0065] Test Example 3 Antifreeze performance test The kill rate of disinfectants in Examples 1 to 8 against Escherichia coli and Staphylococcus aureus was tested at -20℃. The test method was the same as in Test Example 1, and the test time was 10 min.

[0066] The test results are shown in Table 2 below.

[0067] Table 2

[0068] The results showed that the disinfectant prepared by the present invention could achieve a sterilization rate of over 97% against Escherichia coli and Staphylococcus aureus after 10 minutes of sterilization at -20℃. In Example 8, the sterilization rate against both bacteria reached over 99.9%. This indicates that the disinfectant prepared by the formula and preparation method of the present invention has excellent antifreeze properties, can be used normally at -20℃, and does not require increasing the concentration.

[0069] Test Example 4 Cleaning performance test Comparison of ATP detection data before and after cleaning: Since all living cells contain a constant amount of ATP, the ATP content can clearly indicate the amount of microorganisms and other biological residues in the sample, and is used to judge the cleaning status. A comparison of ATP detection data for surgical instruments before and after cleaning with the foam-type purification disinfectant prepared using the embodiments and comparative examples of this invention is shown in Table 3 below.

[0070] Table 3

[0071] The results showed that the foam disinfectant provided by the present invention also has excellent cleaning performance. Compared with Example 2, the cleaning rates of Examples 4-7 and Comparative Examples 1-4 were significantly reduced. It can be seen that the addition of foaming agents and alkyl glycosides to the foam disinfectant of the present invention, in combination with other components, helps to give it excellent cleaning performance.

[0072] The above description of the embodiments is provided to enable those skilled in the art to understand and use the invention. It will be apparent to those skilled in the art that various modifications can be made to these embodiments, and the general principles described herein can be applied to other embodiments without inventive effort. Therefore, the present invention is not limited to the above embodiments, and any improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the invention should be within the protection scope of the present invention.

Claims

1. A foam-type purifying disinfectant, characterized in that, By mass percentage, it contains: benzalkonium chloride 0.15–0.2%, foaming agent 10–15%, alkyl glycoside 0.6–1.5%, polyvinyl alcohol 2–4%, nano-bentonite 0.7–1%, and the balance being water; among which, The foaming agent comprises short-chain alkylhydroxysulfonate betaine with 8 to 12 carbon atoms and long-chain alkylhydroxysulfonate betaine with 20 to 24 carbon atoms.

2. The foam-type purifying disinfectant according to claim 1, characterized in that, The mass ratio of the short-chain alkylhydroxysulfonate to the long-chain alkylhydroxysulfonate is 7-8.5:1.5-3.

3. The foam-type purifying disinfectant according to claim 1, characterized in that, The alkyl glycoside is selected from any one of octyl xyloside, decyl glucoside, and decyl maltose.

4. The foam-type purification and disinfection agent according to claim 1, characterized in that, The mass ratio of the foaming agent to the alkyl glycoside is 10:0.6-1.

5. The foam-type purifying disinfectant according to claim 1, characterized in that, The foam-type purifying disinfectant also includes additives, which are selected from one or more of sodium salicylate, emulsifiers, pH adjusters, and fragrances.

6. The foam-type purifying disinfectant according to any one of claims 1-5, characterized in that, The nano-bentonite is further modified with modified starch before use; the modification includes the following steps: (1) Dissolve carboxymethyl starch in water, add initiator, add acrylic acid and N,N-methylenebisacrylamide, react at 70-80℃ for 2-3 hours, wash, dry and pulverize after reaction to obtain modified starch; (2) The nano-bentonite and modified starch are ultrasonically mixed, ultrasonically dispersed in water, and dried to obtain the final product.

7. The foam-type purifying disinfectant according to claim 6, characterized in that, In step (1), the mass ratio of carboxymethyl starch, acrylic acid, and N,N-methylenebisacrylamide is 1:1.2-2:0.1-0.

2.

8. The foam-type purifying disinfectant according to claim 6, characterized in that, In step (2), the mass ratio of the nano-bentonite to the modified starch is 1:0.4 to 0.

7.

9. A disinfection method, characterized in that, This includes disinfection using the foam-type purifying disinfectant as described in any one of claims 1-8.

10. The disinfection method according to claim 9, characterized in that, The disinfection method includes the following steps: diluting the foam-type purifying disinfectant according to any one of claims 1-8 with water, and then using a foaming spray gun to spray it evenly at a distance of 2-3m from the object to be disinfected, so that a layer of disinfectant foam is evenly attached to the surface of the object to be disinfected, and rinsing with water after 10-30 minutes.

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