Multimodal soft stretchable wearable sensing patch and methods of making and applications thereof

Abstract

The application relates to the technical field of biological interface sensing, in particular to a multi-modal soft stretchable wearable sensing patch as well as a preparation method and application thereof. The sensing patch comprises a stretchable substrate and a blood oxygen sensing unit, an electromyography sensing unit and a muscle sound sensing unit. The stretchable substrate comprises opposite front and back surfaces. The blood oxygen sensing unit and the electromyography sensing unit are sequentially arranged on the front surface of the stretchable substrate. The blood oxygen sensing unit and the electromyography sensing unit are separated by a first encapsulation layer, and the electromyography sensing unit is encapsulated by a second encapsulation layer. The muscle sound sensing unit is located on the back surface of the stretchable substrate. The wearable sensing patch provided by the application can be stably attached to the skin under dynamic conditions. Moreover, multi-modal integrated collection of electromyography, muscle sound and blood oxygen signals can be realized on the sensing patch, and real-time, dynamic and synchronous monitoring of multi-modal signals is realized, thereby providing a reliable basis for comprehensive evaluation of human physiological states.

Description

Technical Field

[0001] This application relates to the field of biointerface sensing technology, and in particular to a multimodal, soft, and stretchable wearable sensing patch, its preparation method, and its application. Background Technology

[0002] With the development of wearable electronics and flexible sensing technologies, the demand for continuous, real-time, and non-invasive monitoring of human physiological information is increasing. Existing wearable devices mostly focus on acquiring single-modal signals, such as detecting electromyography (EMG) signals through surface electrodes, detecting blood oxygen saturation (SpO2) through photoplethysmography (PPG), or acquiring the acoustic response of muscles (AMG) through accelerometers and piezoelectric sensors. These single-modal detection methods have been applied to some extent in clinical diagnosis, sports rehabilitation, and health management. However, because human physiological processes often involve complex couplings of electrical activity, mechanical behavior, and hemodynamics, relying solely on single-modal signals is insufficient to comprehensively and accurately reflect the human body's state. Therefore, academia and industry are increasingly focusing on the simultaneous monitoring of multimodal physiological signals, hoping to achieve a comprehensive characterization of human physiological activities by integrating electrical, mechanical, and optical signals.

[0003] However, most current multimodal wearable devices employ cross-device or cross-site collaborative acquisition methods, lacking integrated structural design between devices. This makes it difficult to guarantee the temporal synchronization and spatial consistency of different modal signals under dynamic conditions. Furthermore, existing integration solutions primarily focus on bimodal monitoring and have not yet achieved the integration and real-time dynamic synchronous acquisition of electromyography (EMG), myoacoustic, and blood oxygenation signals within a single flexible and stretchable wearable patch. Therefore, how to achieve high-quality acquisition and dynamic synchronous monitoring of multimodal signals on a single flexible and stretchable platform has become a crucial problem that urgently needs to be solved in current wearable health monitoring technology. Summary of the Invention

[0004] This application provides a multimodal, soft, and stretchable wearable sensing patch, its preparation method, and its application, enabling real-time, dynamic, and synchronous monitoring of multimodal signals, thereby providing a reliable basis for the comprehensive assessment of human physiological state.

[0005] To address the aforementioned technical problems, in a first aspect, embodiments of this application provide a wearable sensing patch, comprising: a stretchable substrate and a blood oxygen sensing unit, an electromyography (EMG) sensing unit, and a myoacoustic sensing unit integrated on the stretchable substrate; the stretchable substrate includes a front side and a back side facing each other; the blood oxygen sensing unit and the EMG sensing unit are sequentially disposed on the front side of the stretchable substrate, with the blood oxygen sensing unit positioned close to the stretchable substrate and the EMG sensing unit positioned above the blood oxygen sensing unit; the blood oxygen sensing unit and the EMG sensing unit are separated by a first encapsulation layer, and the EMG sensing unit is encapsulated by a second encapsulation layer; the myoacoustic sensing unit is located on the back side of the stretchable substrate; the myoacoustic sensing unit is encapsulated by a third encapsulation layer.

[0006] In some exemplary embodiments, the blood oxygen sensing unit includes a blood oxygen sensing element connected to a wire disposed on the front side of a stretchable substrate.

[0007] In some exemplary embodiments, the blood oxygen sensing element is fixed to the front side of a stretchable substrate by an adhesive.

[0008] In some exemplary embodiments, the electromyography sensing unit includes electromyography electrodes made of gold.

[0009] In some exemplary embodiments, the myosophy sensing unit includes a myosophy sensing element connected to a wire disposed on the back side of a stretchable substrate.

[0010] In some exemplary embodiments, the myosomatic sensing element is fixed to the back side of a stretchable substrate by an adhesive.

[0011] Secondly, this application also provides a method for preparing a multimodal flexible and stretchable wearable sensing patch. This method is used to prepare the multimodal flexible and stretchable wearable sensing patch described in the above embodiments. The method includes the following steps: First, a stretchable substrate is provided; the stretchable substrate includes a front side and a back side; then, a wire for connecting a blood oxygen sensing element is formed on the front side of the stretchable substrate; the blood oxygen sensing element is placed on the wire, and an adhesive is used to fix the blood oxygen sensing element to the front side of the stretchable substrate; next, the blood oxygen sensing element is encapsulated using an encapsulation material to form... The encapsulation layer of the blood oxygen sensing unit; next, using the encapsulation layer of the blood oxygen sensing unit as a substrate, electromyographic electrodes are formed on the substrate; the electromyographic electrodes are encapsulated with an encapsulation material to form the encapsulation layer of the electromyographic sensing unit; then, the stretchable substrate integrating the blood oxygen sensing unit and the electromyographic sensing unit is flipped over, and wires for connecting the myoacoustic sensing components are formed on the back side of the stretchable substrate; the myoacoustic sensing components are placed on the wires, and the myoacoustic sensing components are fixed to the back side of the stretchable substrate with an adhesive; finally, the myoacoustic sensing components are encapsulated with an encapsulation material to form the encapsulation layer of the myoacoustic sensing unit.

[0012] In some exemplary embodiments, wires for connecting blood oxygen sensing components are formed by depositing gold on the front side of the stretchable substrate; and wires for connecting myositis sensing components are formed by depositing gold on the back side of the stretchable substrate.

[0013] In some exemplary embodiments, the endpoints of all wires are dotted with liquid metal to improve the electrical connection between the wires and the blood oxygen sensing element or myoacoustic sensing element.

[0014] Thirdly, this application also provides an application of the wearable sensing patch described in the above embodiments in scenarios such as sports assessment and monitoring, rehabilitation training monitoring, and wearable health monitoring.

[0015] The technical solution provided in this application has at least the following advantages:

[0016] This application provides a multimodal, flexible, and stretchable wearable sensing patch, its preparation method, and its application. The sensing patch includes: a stretchable substrate and a blood oxygen sensing unit, an electromyography (EMG) sensing unit, and a myoacoustic sensing unit integrated on the stretchable substrate; the stretchable substrate includes a front side and a back side facing each other; the blood oxygen sensing unit and the EMG sensing unit are sequentially disposed on the front side of the stretchable substrate, with the blood oxygen sensing unit positioned close to the stretchable substrate and the EMG sensing unit positioned above the blood oxygen sensing unit; the blood oxygen sensing unit and the EMG sensing unit are separated by a first encapsulation layer, and the EMG sensing unit is encapsulated by a second encapsulation layer; the myoacoustic sensing unit is located on the back side of the stretchable substrate; the myoacoustic sensing unit is encapsulated by a third encapsulation layer. This application provides a multimodal, soft, and stretchable wearable sensing patch that can stably adhere to the skin under dynamic conditions. Moreover, the sensing patch can achieve multimodal integrated acquisition of electromyography, myosophyll, and blood oxygenation signals, and realize real-time, dynamic, and synchronous monitoring of multimodal signals, thereby providing a reliable basis for the comprehensive assessment of human physiological state. Attached Figure Description

[0017] One or more embodiments are illustrated by way of example with reference to the accompanying drawings. These illustrations do not constitute a limitation on the embodiments, and unless otherwise stated, the figures in the drawings are not to be limited by scale.

[0018] Figure 1 This is a schematic diagram of the structure of a multimodal, soft, and stretchable wearable sensing patch provided in an embodiment of this application.

[0019] Figure 2 This is a schematic flowchart illustrating a method for preparing a multimodal, soft, and stretchable wearable sensing patch, as provided in an embodiment of this application. Detailed Implementation

[0020] As the background technology indicates, most existing wearable sensors focus on detecting single physiological signals, such as electromyography (EMG), myoacoustic waves, or blood oxygen saturation. There is currently no solution capable of integrating and monitoring multimodal physiological signals on a single, flexible, and stretchable platform. This limits the comprehensive assessment of complex physiological states and prevents real-time dynamic correlation analysis between different modal signals. Furthermore, existing monitoring devices are often too rigid or lack sufficient flexibility, making it difficult to maintain a stable fit and acquire high-quality signals during human movement.

[0021] Existing research has explored various aspects of multimodal monitoring. For example, some studies have reported integrating electrodes and acoustic sensors onto flexible, stretchable patches to achieve simultaneous dual-modal monitoring of electromyography (EMG) signals and acoustic myography (AMG). This approach allows for the simultaneous acquisition of electrical and mechanical signals on the same platform, enriching the methods for characterizing muscle activity, but optical modules for blood oxygen monitoring have not yet been introduced. Other researchers have proposed combining pressure sensors with flexible fiber structures to achieve simultaneous acquisition of EMG signals and force myography (FMG), validating the complementary value of mechanical and electrical signals. However, these dual-modal systems still have limitations in terms of functional completeness.

[0022] On the other hand, in the field of blood oxygen monitoring, the integration of flexible organic photodiodes (OPDs) and organic light-emitting diodes (OLEDs) has been applied to reflective blood oxygen detection, enabling flexible and array-based optical monitoring. Other studies have employed polarization-selective flexible optical structures, effectively reducing motion artifacts and maintaining high signal quality under dynamic conditions. These achievements demonstrate the feasibility of blood oxygen monitoring modules on flexible and stretchable platforms. Simultaneously, some studies are attempting to integrate electromyography (EMG) monitoring with other physiological signals (such as temperature, strain, or pressure) onto the same flexible patch to achieve simultaneous acquisition of multi-sensor information.

[0023] However, based on currently available patents and journal reports, no literature or device has yet achieved the integration and synchronous dynamic monitoring of electromyography (EMG), myoacoustic, and blood oxygenation signals on a single soft, stretchable patch. Existing technologies are either limited to dual-modality or achieve multimodal data fusion through cross-device collaborative measurements, but neither meets the requirement of simultaneously acquiring multimodal electrical, mechanical, and optical signals within a single device.

[0024] In summary, the existing technology has the following main shortcomings:

[0025] (1) Single monitoring modality and insufficient information dimensions: Most wearable sensors currently monitor only one type of physiological signal, such as recording electromyography (EMG) signals through electrodes, acquiring muscle acoustic or mechanical signals (MMG / AMG) through piezoelectric or accelerometer sensors, and monitoring blood oxygen (SpO2 / PPG) through optical sensors. Although a single modality signal can reflect a certain aspect of physiological characteristics, it is difficult to comprehensively present the complex electrical, mechanical and hemodynamic processes of the human body, thus limiting the comprehensive assessment of physiological state.

[0026] (2) Insufficient multimodal integration, and the function remains at the bimodal level: Existing multimodal wearable devices are mostly concentrated on bimodal integration, such as the combination of electromyography and myosophyll, or the combination of electromyography and mechanical signals. Although such solutions have enriched the monitoring methods to a certain extent, they have not yet achieved integrated monitoring of three types of signals: electromyography, myosophyll, and blood oxygenation, and cannot meet the needs of real-time, dynamic, and synchronous analysis between multimodal signals.

[0027] (3) Poor signal stability under dynamic conditions: Some existing flexible or wearable sensors can obtain good signals under static conditions, but they are prone to signal drift, increased noise, or even acquisition failure when the human body moves or the skin is stretched. This is mainly due to their insufficient softness and stretchability, which leads to unstable contact between the electrodes, acoustic or optical components and the skin, limiting their application in dynamic monitoring scenarios such as motion assessment and rehabilitation training.

[0028] Therefore, this application aims to fill this technological gap by proposing a multimodal, flexible, and stretchable wearable sensing patch, its fabrication method, and its application, which enables real-time dynamic synchronous monitoring of electromyography (EMG), myosomal, and blood oxygenation signals under dynamic conditions. The wearable sensing patch includes: a stretchable substrate and a blood oxygenation sensing unit, an EMG sensing unit, and an EMG sensing unit integrated on the stretchable substrate; the stretchable substrate includes a front and a back side facing each other; the blood oxygenation sensing unit and the EMG sensing unit are sequentially disposed on the front side of the stretchable substrate, with the blood oxygenation sensing unit positioned close to the stretchable substrate and the EMG sensing unit positioned above the blood oxygenation sensing unit; the blood oxygenation sensing unit and the EMG sensing unit are separated by a first encapsulation layer, and the EMG sensing unit is encapsulated by a second encapsulation layer; the EMG sensing unit is located on the back side of the stretchable substrate; the EMG sensing unit is encapsulated by a third encapsulation layer.

[0029] This sensing patch integrates electromyography (EMG), myoacoustic, and blood oxygenation monitoring modules into a single device, enabling real-time dynamic synchronous acquisition of these three types of physiological signals. This allows for a comprehensive and accurate reflection of the body's physiological state. The patch's flexible and stretchable structural design ensures excellent adhesion and stability to the skin surface, maintaining signal quality even under motion and dynamic conditions. Furthermore, this invention provides a new technological pathway for exercise assessment, rehabilitation training, disease monitoring, and health management through the integrated and synchronous monitoring of multimodal signals. It overcomes the limitations of existing technologies that only provide single-modal or dual-modal monitoring, expanding the application scope of wearable health monitoring systems.

[0030] The embodiments of this application will now be described in detail with reference to the accompanying drawings. However, those skilled in the art will understand that many technical details have been provided in the embodiments of this application to facilitate a better understanding of the application. However, the technical solutions claimed in this application can be implemented even without these technical details and various variations and modifications based on the following embodiments.

[0031] See Figure 1 This application provides a multimodal, soft, and stretchable wearable sensing patch, comprising: a stretchable substrate 100 and a blood oxygen sensing unit 101, an electromyography (EMG) sensing unit 102, and a myoacoustic sensing unit 103 integrated on the stretchable substrate 100; the stretchable substrate 100 includes a front side and a back side facing each other; the blood oxygen sensing unit 101 and the EMG sensing unit 102 are sequentially disposed on the front side of the stretchable substrate 100, with the blood oxygen sensing unit 101 disposed close to the stretchable substrate 100 and the EMG sensing unit 102 disposed above the blood oxygen sensing unit 101; the blood oxygen sensing unit 101 and the EMG sensing unit 102 are separated by a first encapsulation layer 104, and the EMG sensing unit 102 is encapsulated by a second encapsulation layer 105; the myoacoustic sensing unit 103 is located on the back side of the stretchable substrate 100; the myoacoustic sensing unit 103 is encapsulated by a third encapsulation layer 106.

[0032] The multimodal, flexible, and stretchable wearable sensing patch provided in this application includes a stretchable substrate 100 (flexible substrate), a blood oxygenation sensing unit 101, an electromyography (EMG) sensing unit 102, and a myosomatic sounding (MMS) sensing unit 103. Each sensing unit is rationally arranged and integrated on the flexible substrate. By optimizing the arrangement of the sensing units and selecting conductive materials, efficient coupling between various signal units is achieved while ensuring the overall flexibility and wearing comfort of the sensing patch. This sensing patch uses a multi-channel acquisition system to simultaneously acquire EMG, MMS, and blood oxygenation signals, ensuring temporal synchronization and spatial coupling efficiency between different signals. This enables the simultaneous acquisition of multimodal physiological information, improving the accuracy and reliability of multimodal monitoring and solving the problems of simple sensor structure, asynchronous multimodal signals, and high integration difficulty in existing technologies.

[0033] In some embodiments, the blood oxygen sensing unit 101 includes a blood oxygen sensing element, which is connected to a wire disposed on the front side of the stretchable substrate 100.

[0034] In some embodiments, the blood oxygen sensing element is fixed to the front side of the stretchable substrate 100 by an adhesive.

[0035] In some embodiments, the electromyography sensing unit 102 includes electromyography electrodes made of gold.

[0036] In some embodiments, the myosophy sensing unit 103 includes a myosophy sensing element connected to a wire disposed on the back side of the stretchable substrate 100.

[0037] In some embodiments, the myosomatic sensing element is fixed to the back of the stretchable substrate 100 by an adhesive.

[0038] See Figure 2 This application also provides a method for preparing a wearable sensing patch, which is used to prepare the wearable sensing patch described in the above embodiments. The method includes the following steps.

[0039] Step S1: Provide a stretchable substrate; the stretchable substrate includes a front side and a back side.

[0040] Step S2: Form wires for connecting the blood oxygen sensing element on the front side of the stretchable substrate; place the blood oxygen sensing element on the wires and fix the blood oxygen sensing element to the front side of the stretchable substrate using an adhesive.

[0041] Step S3: Use encapsulation material to encapsulate the blood oxygen sensing element to form an encapsulation layer for the blood oxygen sensing unit.

[0042] Step S4: Using the encapsulation layer of the blood oxygen sensing unit as a substrate, form electromyographic electrodes on the substrate; encapsulate the electromyographic electrodes with encapsulation material to form the encapsulation layer of the electromyographic sensing unit.

[0043] Step S5: Flip the stretchable substrate integrating the blood oxygen sensing unit and the electromyography sensing unit to form a wire for connecting the myoacoustic sensing element on the back of the stretchable substrate; place the myoacoustic sensing element on the wire and fix the myoacoustic sensing element to the back of the stretchable substrate with an adhesive.

[0044] Step S6: Use encapsulation material to encapsulate the muscle acoustic sensing components to form the encapsulation layer of the muscle acoustic sensing unit.

[0045] In some embodiments, in step S2, gold is deposited on the front side of the stretchable substrate to form wires for connecting blood oxygen sensing components; in step S5, gold is deposited on the back side of the stretchable substrate to form wires for connecting myosomal sensing components.

[0046] In some embodiments, the endpoints of all wires are dotted with liquid metal to improve the electrical connection between the wires and the blood oxygen sensing element or myoacoustic sensing element.

[0047] The following detailed description of the multimodal, flexible, and stretchable wearable sensing patch and its preparation method provided in this application is based on specific embodiments.

[0048] The multimodal, flexible, and stretchable wearable sensing patch is fabricated layer by layer. Specifically, two layers of Ecoflex 00-20 (A:B mixing ratio of 1:1, 100 rpm, 1 min) are first spin-coated onto an acrylic plate as a stretchable substrate. The stretchable substrate includes opposing front and back sides, such as... Figure 1 As shown, as an example, the top surface of the stretchable substrate 100 can be used as the front surface and its bottom surface as the back surface.

[0049] Then, after heat curing, gold (400 nm, 10 Å / s) is vapor-deposited on the front side of the stretchable substrate as the wire for the blood oxygen sensing element. Liquid metal is applied to the endpoints of the wire to improve the electrical connection between the wire and the blood oxygen sensing element. The blood oxygen sensing element is placed on the gold wire, and then silicone sealant is applied around the blood oxygen sensing element to make it firmly adhere to the stretchable substrate.

[0050] After all the blood oxygen sensing components are fixed, spin-coat a layer of Ecoflex 00-20 (A:B mixing ratio of 1:1, 100 rpm, 1 min) onto them as an encapsulation layer for the blood oxygen sensing unit (e.g. Figure 1 The first encapsulation layer (as shown in 104) and the base layer of the electromyography electrode are heat-cured and then gold is vapor-deposited (400 nm, 10 Å / s) on them as the electromyography electrode. An Ecoflex 00-20 thin layer is then spin-coated onto the electromyography electrode (1500 rpm, 1 min) to form the encapsulation layer of the electromyography sensing unit (as shown in 104). Figure 1 As shown in the second encapsulation layer 105, the electromyography electrode is encapsulated, thereby completing the integration of the blood oxygen sensing unit and the electromyography sensing unit.

[0051] Subsequently, the stretchable substrate was flipped over, and gold was deposited on the back side (400 nm, 10 Å / s) as the conductor for the myosomal sensing element. Liquid metal was applied to the ends of the conductor to improve the electrical connection between the conductor and the myosomal sensing element. The myosomal device was placed on the gold conductor, and then silicone sealant was applied around the myosomal device to firmly adhere it to the stretchable substrate. After all the myosomal sensing elements were fixed, a layer of Ecoflex 00-20 (A:B mixing ratio of 1:1, 100 rpm, 1 min) was spin-coated on top as the encapsulation layer for the myosomal sensing unit (e.g., ...). Figure 1 The third encapsulation layer 106 is shown. A thin layer of Ecoflex 00-20 is spin-coated (1500 rpm, 1 min) to encapsulate the wires of the myoacoustic sensing unit.

[0052] To establish the connection between the flexible, stretchable wearable sensing patch and the FPCB, this application employs liquid metal. This process involves coating the tails of all wires and electrodes with liquid metal using a mask roll coating method. Subsequently, the leads of the FPCB are connected to the liquid metal, and then firmly secured to the flexible, stretchable wearable sensing patch using silicone sealant. After the silicone sealant has completely cured, a complete, integrated, multimodal flexible, stretchable wearable sensing patch is obtained.

[0053] This application provides a method for integrating multimodal sensing units. By constructing and strategically arranging electromyography (EMG), myoacoustic, and blood oxygenation (POO) sensing units layer by layer on a flexible substrate, and then integrating the three sensing units through methods such as vapor-depositing wires on a stretchable substrate, spot-coating liquid metal to enhance electrical connections, placing and fixing each sensing element, and sequentially spin-coating flexible material for encapsulation, the integrated method ensures efficient spatial coupling between the multimodal sensing units, improves the accuracy and reliability of overall signal acquisition, and avoids interference between different modal signals.

[0054] Furthermore, this application also provides a three-modal synchronous acquisition method, which uses a multi-channel acquisition system to synchronously acquire electromyography, myosophyll, and blood oxygenation signals, ensuring the consistency of each modality signal in time and space, and improving the correlation and accuracy of multimodal physiological information.

[0055] Furthermore, this application also provides an application of the multimodal soft and stretchable wearable sensing patch described in the above embodiments in scenarios such as motion assessment and monitoring, rehabilitation training monitoring, and wearable health monitoring.

[0056] The applications of multimodal soft and stretchable wearable patches include: the design of this sensing patch takes into account flexibility, wearing comfort and multimodal signal acquisition performance, can adapt to different body parts and movement states, ensures stable acquisition of multimodal physiological information in actual use, and has good application value and promotion potential.

[0057] Compared with existing technologies, the modally flexible and stretchable wearable sensing patch and its preparation method provided in this application have the following advantages:

[0058] (1) Trimodal synchronous acquisition: The sensing patch of this application can simultaneously acquire electromyography, myosalpingography and blood oxygenation signals, realizing true trimodal synchronous monitoring. The time synchronization and spatial coupling between different signals are guaranteed, which can accurately reflect the correlation of multiple physiological activities. In the prior art, multimodal sensing patches usually have each signal unit working independently, and the acquired signals have time delays or are not correlated with each other, making it difficult to provide high-precision multimodal data.

[0059] (2) Integrated sensor patch structure: By rationally arranging the various sensing units and optimizing the flexible substrate and conductive materials, this application achieves efficient integration of multimodal sensing units. The overall structure is compact, flexible, comfortable to wear, and can conform to the complex curvature of the skin, making it easy to use. In contrast, existing technologies are mostly distributed or rigid sensors, which are bulky and difficult to adapt to the curvature of the skin.

[0060] (3) High-efficiency signal coupling: The coupling efficiency between each sensing unit is high, and the signals do not interfere with each other, ensuring the accuracy and reliability of multimodal data acquisition. Existing multimodal sensors often experience interference or accuracy degradation during signal acquisition. This application effectively avoids this problem by optimizing the layout and material selection.

[0061] (4) Strong adaptability and practicality: The sensor patch design of this application takes into account flexibility, wearing comfort and multimodal signal acquisition performance, adapts to different human body parts and movement states, and can stably collect physiological information. Compared with the prior art, this application has more practical value and application prospects in actual use.

[0062] The sensor patch structure and trimodal synchronous monitoring function of this application have been experimentally verified. In the experiments, the prepared flexible sensor patch was tested on the forearm and other parts of the human body, simultaneously acquiring electromyography, myosalpingography, and blood oxygenation signals. The three modal data achieved time synchronization and no interference between them. By acquiring signals from different movements (such as clenching a fist and extending the arm) and at rest, the response sensitivity and signal coupling efficiency of each sensing unit were verified. Experimental results show that the wearable fat sensor patch of this application can stably acquire high-precision multimodal physiological data. The sensor patch exhibits good flexibility and wearing comfort, verifying the feasibility and effectiveness of the technical solution of this application.

[0063] Based on the above technical solutions, this application provides a multimodal, soft, and stretchable wearable sensing patch, its preparation method, and its application. The sensing patch includes: a stretchable substrate 100 and a blood oxygen sensing unit 101, an electromyography (EMG) sensing unit 102, and a myoacoustic sensing unit 103 integrated on the stretchable substrate 100; the stretchable substrate 100 includes a front side and a back side facing each other; the blood oxygen sensing unit 101 and the EMG sensing unit 102 are sequentially disposed on the front side of the stretchable substrate 100, with the blood oxygen sensing unit 101 disposed close to the stretchable substrate 100 and the EMG sensing unit 102 disposed above the blood oxygen sensing unit 101; the blood oxygen sensing unit 101 and the EMG sensing unit 102 are separated by a first encapsulation layer 104, and the EMG sensing unit 102 is encapsulated by a second encapsulation layer 105; the myoacoustic sensing unit 103 is located on the back side of the stretchable substrate 100; the myoacoustic sensing unit 103 is encapsulated by a third encapsulation layer 106. This application provides a multimodal, soft, and stretchable wearable sensing patch that can stably adhere to the skin under dynamic conditions. Moreover, the sensing patch can achieve multimodal integrated acquisition of electromyography, myosophyll, and blood oxygenation signals, and realize real-time, dynamic, and synchronous monitoring of multimodal signals, thereby providing a reliable basis for the comprehensive assessment of human physiological state.

[0064] Those skilled in the art will understand that the above-described embodiments are specific examples of implementing this application, and in practical applications, various changes in form and detail may be made without departing from the spirit and scope of this application. Any person skilled in the art can make their own modifications and alterations without departing from the spirit and scope of this application; therefore, the scope of protection of this application should be determined by the scope defined in the claims.

Claims

1. A multi-modal soft stretchable wearable sensing patch, characterized in that, include: A stretchable substrate and a blood oxygen sensing unit, an electromyography (EMG) sensing unit, and a myoacoustic sensing unit integrated on the stretchable substrate; the blood oxygen sensing unit includes blood oxygen sensing components; the EMG sensing unit includes EMG electrodes; and the myoacoustic sensing unit includes myoacoustic sensing components. The stretchable substrate includes opposing front and back sides; The blood oxygen sensing unit and the electromyography (EMG) sensing unit are sequentially disposed on the front side of the stretchable substrate, with the blood oxygen sensing unit disposed close to the stretchable substrate and the EMG sensing unit disposed above the blood oxygen sensing unit; the blood oxygen sensing unit and the EMG sensing unit are separated by a first encapsulation layer, and the EMG sensing unit is encapsulated by a second encapsulation layer. The myoacoustic sensing unit is located on the back side of the stretchable substrate; the myoacoustic sensing unit is encapsulated by a third encapsulation layer.

2. The multi-modal soft stretchable wearable sensing patch of claim 1, wherein, The blood oxygen sensing unit includes a blood oxygen sensing element, which is connected to a wire disposed on the front side of the stretchable substrate.

3. The multi-modal soft stretchable wearable sensing patch of claim 2, wherein, The blood oxygen sensing element is fixed to the front side of the stretchable substrate by an adhesive.

4. The multi-modal soft and stretchable wearable sensing patch of claim 1, wherein, The electromyography sensing unit includes electromyography electrodes, and the electromyography electrodes are made of gold.

5. The multi-modal soft and stretchable wearable sensing patch of claim 1, wherein, The myosophytic sensing unit includes a myosophytic sensing element, which is connected to a wire disposed on the back side of the stretchable substrate.

6. The multi-modal soft and stretchable wearable sensing patch of claim 5, wherein, The myosomatic sensing element is fixed to the back of the stretchable substrate by an adhesive.

7. A method of making a multi-modal soft stretchable wearable sensing patch, the method for making the multi-modal soft stretchable wearable sensing patch according to any one of claims 1 to 6, characterized in that, The method includes the following steps: A stretchable substrate is provided; the stretchable substrate includes opposing front and back sides; A wire for connecting a blood oxygen sensor is formed on the front side of the stretchable substrate; the blood oxygen sensor is placed on the wire and fixed to the front side of the stretchable substrate with an adhesive. The blood oxygen sensing components are encapsulated using encapsulation materials to form an encapsulation layer for the blood oxygen sensing unit. Using the encapsulation layer of the blood oxygen sensing unit as a substrate, electromyographic electrodes are formed on the substrate; the electromyographic electrodes are encapsulated with encapsulation material to form the encapsulation layer of the electromyographic sensing unit. The stretchable substrate integrating the blood oxygen sensing unit and the electromyography sensing unit is flipped over, and a wire for connecting the myoacoustic sensing element is formed on the back of the stretchable substrate; the myoacoustic sensing element is placed on the wire, and the myoacoustic sensing element is fixed to the back of the stretchable substrate with an adhesive. The myoacoustic sensing components are encapsulated using encapsulation materials to form an encapsulation layer for the myoacoustic sensing unit.

8. The method of claim 7, wherein the multilayered soft stretchable wearable sensing patch is prepared by, By depositing gold on the front side of the stretchable substrate, wires for connecting blood oxygen sensing components are formed. By depositing gold on the back side of the stretchable substrate, wires for connecting myosomatic sensing components are formed.

9. The method of claim 7, wherein the multi-modal soft stretchable wearable sensing patch is prepared by, All wire endpoints are dotted with liquid metal to improve the electrical connection between the wires and the blood oxygen sensor or myoacoustic sensor.

10. The application of a multimodal, soft, and stretchable wearable sensing patch as described in any one of claims 1 to 6 in motion assessment and monitoring, rehabilitation training monitoring, and wearable health monitoring scenarios.

Images