Traditional Chinese medicine decoction boiling device and traditional Chinese medicine formula

By designing an automated decoction preparation device and a specific formula, the problem of inconvenient decoction preparation of traditional Chinese medicine was solved, realizing automated decoction preparation and quantitative distribution of traditional Chinese medicine, thus enhancing the treatment effect of colorectal cancer.

CN121102014APending Publication Date: 2025-12-12SUZHOU TRADITIONAL CHINESE MEDICINE HOSPITAL
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Patent Information

Application Number
CN202510216324.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-02-26
Publication Date
2025-12-12

AI Technical Summary

Technical Problem

When treating colorectal cancer with traditional Chinese medicine, the decoction equipment for the herbs needs to be heated manually and the dosage cannot be controlled, making it inconvenient to take the medicine.

Method used

A traditional Chinese medicine decoction preparation device was designed, including a heating structure, a decoction structure, and a mixing and separation structure. The device achieves automatic decoction and dosage control of medicinal materials through a lifting chamber and a guide screw, and enhances the therapeutic effect by combining it with a specific traditional Chinese medicine formula.

Benefits of technology

It has enabled the automated preparation and quantitative distribution of traditional Chinese medicine decoctions, improving the convenience and efficacy of treatment. In particular, when combined with PD1 therapy, it enhances the sensitivity to immunotherapy and inhibits tumor growth.

✦ Generated by Eureka AI based on patent content.

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Abstract

The traditional Chinese medicine decoction boiling device comprises a mixing and separating structure, the mixing and separating structure comprises a lifting bin, a vertical plate is arranged at the bottom of the lifting bin, a connecting plate is arranged under the vertical plate, a clamping ring is arranged at the top of the connecting plate, and the clamping ring is connected with the vertical plate in a clamped mode; a flow dividing hole is formed in the connecting plate, and the connecting plate is connected with the flow dividing groove in a sliding mode. The device is reasonable in design, a traditional Chinese medicine formula is put into the filtering barrel, then the filtering barrel moves downwards, medicinal materials enter the boiling pot to be soaked, then the medicinal materials in the boiling pot are boiled through the heating device, the mixing and separating device moves upwards after boiling, and the traditional Chinese medicine formula is mixed and separated. The mixing and separating device drives the connecting plate at the bottom to block the containing groove, only decoction boiled between the two partition plates needs to be discharged subsequently, decoction at different positions is discharged subsequently, and therefore the dosage of medicine taken in the morning, noon and evening is achieved.
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Description

TECHNICAL FIELD

[0001] The present application mainly relates to the field of intestinal cancer treatment, and particularly relates to a traditional Chinese medicine decoction cooking device and a traditional Chinese medicine formula. BACKGROUND

[0002] Intestinal cancer mainly includes rectal cancer, colon cancer and the like, and can be caused by factors such as heredity, lifestyle, eating habits, chronic inflammation of the intestines. Intestinal cancer patients can have no obvious symptoms in the early stage, and can have symptoms such as diarrhea, constipation, hematochezia, abdominal pain, abdominal mass, anemia, and weight loss when the disease develops to a certain degree.

[0003] The method for treating intestinal cancer by traditional Chinese medicine mainly includes regulating yin and yang, soothing the liver and regulating qi, promoting blood circulation to remove blood stasis, and the like, and the treatment is performed according to different stages of intestinal cancer and the disease conditions of patients.

[0004] The inventor found the following defects in the specific embodiment operation process.

[0005] Among them, the intestinal cancer patients need to cook traditional Chinese medicinal materials by using a decoction cooking device when taking traditional Chinese medicine for adjuvant therapy, but traditional Chinese medicine is generally taken before and after meals, and a set of medicine is used for one day. However, the traditional Chinese medicine needs to be heated and the amount of traditional Chinese medicine poured out cannot be controlled each time.

[0006] It should be noted that the above content belongs to the technical cognition of the inventor. Since the technical content in the art is vast and complex, the above content of the present application does not necessarily constitute the prior art. SUMMARY

[0007] 1. Technical problem to be solved by the present application:

[0008] The present application provides a traditional Chinese medicine decoction cooking device and a traditional Chinese medicine formula to solve the technical problems in the background art.

[0009] 2. Technical solution:

[0010] To achieve the above purpose, the technical solution provided by the present application is: a traditional Chinese medicine decoction cooking device and a traditional Chinese medicine formula, comprising a heating structure, a cooking structure is arranged on the top of the heating structure, a top sealing structure is arranged on the top of the cooking structure, and the top sealing structure;

[0011] The cooking structure comprises a cooking pot, a support column is arranged in the middle of the cooking pot, side grooves are formed in the outer wall of the support column and the inner side of the cooking pot, a partition plate is arranged between the two side grooves, a placing groove is formed in the inside of the partition plate, and a shunt groove is formed in the inside of the partition plate.

[0012] The mixed separation structure includes a lifting bin, the bottom of the lifting bin is provided with a vertical plate, the vertical plate is provided with a connecting plate below, the top of the connecting plate is provided with a snap ring, the snap ring is connected with the vertical plate, the inside of the connecting plate is provided with a shunt hole, and the connecting plate is slidably connected with a shunt groove.

[0013] Further, the heating structure includes a shell, the inside of the shell is provided with an air guide pipe, the middle of the inner wall of the shell is provided with a support ring, and the outer wall of the shell is provided with a fitting groove.

[0014] Further, the outer wall of the decoction pot is provided with a valve, the valve is aligned with the fitting groove, and the inner wall of the decoction pot is rotatably connected with a guide screw rod on both sides.

[0015] Further, the top sealing structure includes that the top of the sealing cover is rotatably connected with a transmission gear ring, the top of the sealing cover is rotatably connected with an intermediate gear, and the top of the sealing cover is rotatably connected with an inner gear.

[0016] Further, the number of intermediate gears is multiple, and the multiple intermediate gears are arranged in an annular array on the top of the sealing cover.

[0017] Further, the bottom of the intermediate gear is provided with a rotating shaft, the bottom of the rotating shaft is provided with a sealing block, the sealing block is in the shape of a circular truncated cone, the bottom of the sealing block is provided with a first spring rod, and the outer wall of the first spring rod is provided with a first stirring rod.

[0018] Further, the bottom of the inner gear is provided with a bottom rod, the bottom of the bottom rod is provided with a second spring rod, and one end of the bottom of the second spring rod is provided with a second stirring rod.

[0019] Further, the two sides of the lifting bin are provided with matching holes, the matching holes are matched with the guide screw rod, the inner side of the lifting bin is provided with a guide ring, the inside of the lifting bin is provided with an auxiliary ring, the bottom of the auxiliary ring is provided with a filter barrel, a circular truncated cone groove is formed in the middle of the auxiliary ring, and the inner wall of the groove is matched with the sealing block.

[0020] Further, the number of filter barrels is multiple, and the inside of the filter barrel is provided with a first spring rod.

[0021] A traditional Chinese medicine decoction formula is used in a traditional Chinese medicine decoction cooking device, and the traditional Chinese medicine decoction formula has the characteristics that

[0022] The monarch medicine is 30 parts of herba agrimoniae and 15 parts of fried atractylodes, which has the effects of invigorating the spleen, tonifying deficiency, and resisting evil.

[0023] Ministerial medicine: 30 parts of Actinidia root, 30 parts of half branch orchid, 15 parts of snakeberry, which has the effects of clearing heat and detoxifying and resisting tumors;

[0024] Auxiliary medicine: 10 parts of Zedoary Turmeric and 10 parts of Earthworm, which has the effects of breaking blood and removing stasis and stasis caused by long-term disease;

[0025] Medicine: 15 parts of mountain yam and 15 parts of bitter orange fruit, which has the effects of promoting qi and resolving phlegm and phlegm causing many diseases.

[0026] 3. Beneficial effects:

[0027] Compared with the prior art, the technical scheme provided by the present application has the following beneficial effects:

[0028] The present application puts the traditional Chinese medicine formula into the filter barrel, then moves the filter barrel downward, so that the medicinal materials enter the inside of the decocting pot for soaking, and then the medicinal materials in the decocting pot are decocted by the heating device, after decocting, the mixing and separating device moves upward, so that the mixing and separating device drives the bottom connecting plate to block the placement groove, and the decocted decoction between the two partition plates is discharged, and then the decoction at different positions is discharged in turn, so that the amount of medicine for taking in the morning, noon and evening is realized.

[0029] The traditional Chinese medicine formula has good tumor inhibition effect through in vivo pre-experiment verification, and the treatment effect is better after being combined with PD1, which shows that the formula can inhibit tumor growth by enhancing immunotherapy sensitivity. BRIEF DESCRIPTION OF DRAWINGS

[0030] Figure 1 It is a schematic diagram of the three-dimensional structure of the present application;

[0031] Figure 2 It is a schematic diagram of the three-dimensional cross-sectional structure of the present application;

[0032] Figure 3 It is a schematic diagram of the heating structure of the present application;

[0033] Figure 4 It is a schematic diagram of the decocting structure of the present application;

[0034] Figure 5 It is a schematic diagram of the top sealing structure of the present application;

[0035] Figure 6 It is a schematic diagram of the mixing and separating structure of the present application;

[0036] Figure 7 It is an example diagram of animal experiment results of the present application;

[0037] Figure 8 It is a flow phase gradient diagram of the present application;

[0038] Figure 9 Mass Spectrometric Parameter Plot for the Invention;

[0039] Figure 10 Base Peak Chromatogram (BPC) - Negative Ion Mode Plot for the Invention;

[0040] Figure 11 Base Peak Chromatogram (BPC) - Positive Ion Mode Plot for the Invention;

[0041] Figure 12 Ultraviolet Chromatogram for the Invention;

[0042] Figure 13 Gradient Plot for the Invention;

[0043] Figure 14 Mass Spectrometric Parameter Plot for the Invention;

[0044] Figure 15 Base Peak Chromatogram (BPC) - Negative Ion Mode Plot for the Invention;

[0045] Figure 16 Base Peak Chromatogram (BPC) - Positive Ion Mode Plot for the Invention;

[0046] Figure 17 Extracted Ion Chromatogram (EIC) - Negative Ion Mode Plot for the Invention;

[0047] Figure 18 Extracted Ion Chromatogram (EIC) - Positive Ion Mode Plot for the Invention.

[0048] Reference Numerals:

[0049] 1, heating structure; 101, shell; 102, air guide pipe; 103, support ring; 104, fitting groove; 2, boiling structure; 201, boiling pot; 202, valve; 203, guide screw; 204, support column; 205, side groove; 206, partition plate; 207, placing groove; 208, shunt groove; 3, top sealing structure; 301, sealing cover; 302, transmission gear ring; 303, intermediate gear; 304, rotating shaft; 305, sealing block; 306, first spring rod; 307, first stirring rod; 308, inner gear; 309, bottom rod; 310, second spring rod; 311, second stirring rod; 4, mixing and separating structure; 401, lifting bin; 402, matching hole; 403, guide ring; 404, auxiliary ring; 405, filter barrel; 406, vertical plate; 407, connecting plate; 408, snap ring; 409, shunt hole. DETAILED DESCRIPTION

[0050] In order to facilitate the understanding of the present application, a more full description of the present application will be made below with reference to the relevant drawings, which show several embodiments of the present application. However, the present application can be realized in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided to make the disclosure of the present application more thorough and comprehensive.

[0051] In the description of the present application, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "page", "bottom", "inner", "outer", "clockwise", "counterclockwise" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0052] In addition, the terms "first" and "second" are only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features referred to. Therefore, the features defined with "first" and "second" can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "a plurality of" is two or more, unless otherwise explicitly specified and limited.

[0053] In the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connection", "fixing", "provided with", "provided in" and the like should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or it can be integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0054] Embodiments

[0055] Referring to the drawings Figures 1-7 A traditional Chinese medicine decoction cooking device and a traditional Chinese medicine formula, comprising a heating structure 1, the top of the heating structure 1 is provided with a cooking structure 2, the top of the cooking structure 2 is provided with a top sealing structure 3, the top sealing structure 3;

[0056] The decocting structure 2 comprises a decocting pot 201, a support column 204 is arranged in the middle of the decocting pot 201, side grooves 205 are formed in the outer wall of the support column 204 and the inner side of the decocting pot 201, a partition plate 206 is arranged between the two side grooves 205, a placing groove 207 is formed in the inner side of the partition plate 206, a shunt groove 208 is formed in the inner side of the partition plate 206, a valve 202 is arranged on the outer wall of the decocting pot 201, the valve 202 is aligned with the fitting groove 104, guide lead screws 203 are rotatably connected to the two sides of the inner wall of the decocting pot 201, when the decoction of the traditional Chinese medicine formula is completed, the motor is started, the motor drives the guide lead screw 203 to rotate, the guide lead screw 203 drives the lifting bin 401 to move upwards, so that the traditional Chinese medicine formula is separated from the water in the decocting pot 201, at the same time, the shunt hole 409 is separated from the placing groove 207, the decoction between the two partition plates 206 is spaced, and then the valve 202 is opened to discharge the decoction in the interval;

[0057] The mixing and separating structure 4 comprises a lifting bin 401, a vertical plate 406 is arranged at the bottom of the lifting bin 401, a connecting plate 407 is arranged directly below the vertical plate 406, a snap ring 408 is arranged at the top of the connecting plate 407, the snap ring 408 is clamped and connected with the vertical plate 406, a shunt hole 409 is formed in the inner side of the connecting plate 407, the connecting plate 407 is slidably connected with the shunt groove 208, cooperating holes 402 are formed in the two sides of the lifting bin 401, the cooperating holes 402 are matched with the guide lead screws 203, a guide ring 403 is arranged on the inner side of the lifting bin 401, an auxiliary ring 404 is arranged in the inner side of the lifting bin 401, a plurality of filter barrels 405 are arranged at the bottom of the auxiliary ring 404, a circular truncated cone groove is formed in the middle of the auxiliary ring 404, the inner wall of the groove is matched with the sealing block 305, the first spring rods 306 are arranged in the inner sides of the filter barrels 405, when the traditional Chinese medicine formula for treating intestinal cancer needs to be decocted, the monarch, the minister, the assistant and the messenger are simultaneously put into the inner side of the lifting bin 401;

[0058] When the formula is mixed, the motor is started, the guide screw 203 is driven by the motor, the guide screw 203 drives the lifting bin 401 to move down through the matching hole 402, then the lifting bin 401 drives the auxiliary ring 404 to move down, the top inner wall of the filter barrel 405 in the auxiliary ring 404 is separated from the sealing block 305, at the same time, the second spring rod 310 pushes the second stirring rod 311 to move down, so that the second stirring rod 311 is attached to the inner wall of the lifting bin 401, then the second stirring rod 311 sends the traditional Chinese medicine formula in the lifting bin 401 into the inside of the filter barrel 405, the first stirring rod 307 mixes and stirs the traditional Chinese medicine formula in the filter barrel 405, at the same time, when the lifting bin 401 moves down, the shunt hole 409 is aligned with the placing groove 207, and water is sent into the inside of the boiling pot 201 through the water pump, the filter barrel 405 moves down to soak the traditional Chinese medicine formula, and the soaking time is 30 minutes.

[0059] Further, the heating structure 1 comprises a shell 101, a gas guide pipe 102 is arranged in the shell 101, a support ring 103 is arranged on the inner wall of the shell 101, and a fitting groove 104 is formed in the outer wall of the shell 101, after soaking, the heater heats the gas guide pipe 102, then the gas guide pipe 102 heats the traditional Chinese medicine formula in the boiling pot 201 to boil the traditional Chinese medicinal materials.

[0060] Further, the top sealing structure 3, which comprises a top rotating connection of a sealing cover 301 with a transmission gear ring 302, a top rotating connection of the sealing cover 301 with an intermediate gear 303, a top rotating connection of the sealing cover 301 with an internal gear 308, the intermediate gear 303 is engaged with the internal gear 308 and the transmission gear ring 302, the number of the intermediate gear 303 is set to be multiple, multiple intermediate gears 303 are arranged in an annular array on the top of the sealing cover 301, the bottom of the intermediate gear 303 is provided with a rotating shaft 304, the bottom of the rotating shaft 304 is provided with a sealing block 305, the sealing block 305 is arranged in a circular truncated cone shape, the bottom of the sealing block 305 is provided with a first spring rod 306, the outer wall of the first spring rod 306 is provided with a first stirring rod 307, the bottom of the internal gear 308 is provided with a bottom rod 309, the bottom of the bottom rod 309 is provided with a second spring rod 310, one end of the bottom of the second spring rod 310 is provided with a second stirring rod 311, the motor is started, the motor drives the transmission gear ring 302 to rotate, the transmission gear ring 302 drives the intermediate gear 303 to rotate, the intermediate gear 303 drives the rotating shaft 304 to rotate, the rotating shaft 304 drives the sealing block 305, the first spring rod 306 and the first stirring rod 307 to rotate, the first stirring rod 307 stirs and mixes the formula entering the inside of the filter barrel 405 subsequently, at the same time, the intermediate gear 303 drives the internal gear 308 to rotate, the internal gear 308 drives the bottom rod 309 to rotate, the bottom rod 309 drives the second spring rod 310 to rotate, the second spring rod 310 drives the second stirring rod 311 to rotate, the second stirring rod 311 mixes the traditional Chinese medicine in the lifting bin 401 for the first time, so that the monarch, minister and assistant are mixed together.

[0061] A traditional Chinese medicine decoction formula according to a traditional Chinese medicine decoction cooking device, characterized by comprising

[0062] Monarch drug: 30 parts of Xianhecao and 15 parts of fried Baizhu, which has the effect of invigorating the spleen and tonifying deficiency, evil gathering, and gas deficiency;

[0063] Minister drug: 30 parts of Tenglisheng, 30 parts of Banzhu and 15 parts of Shegu, which has the effect of clearing heat and resolving toxicity and resisting tumor;

[0064] Assistant drug: 10 parts of E Zhi and 10 parts of Tuobiechong, which has the effect of breaking blood and removing stasis and stasis caused by long-term disease;

[0065] Making drug: 15 parts of Shancigu and 15 parts of Zhishi, which has the effect of promoting qi and resolving phlegm and phlegm causing many diseases.

[0066] Sample:

[0067] Compound sample

[0068] Acetonitrile, mass spectrometry pure, D618978;

[0069] Methanol, mass spectrometry pure, D618975;

[0070] Water, purified water, 20240717C;

[0071] Formic acid, mass spectrometry pure, B2307771.

[0072] Instrument used

[0073] Waters H-Class ultra-performance liquid chromatograph, Waters Corporation;

[0074] 4600 high-resolution mass spectrometer, SCIEX Corporation;

[0075] Electronic balance, ME104, Mettler-Toledo International Trade (Shanghai) Co., Ltd.;

[0076] Ultrasonic cleaner, KQ-300BD, Kunshan Ultrasonic Instrument Co., Ltd.;

[0077] High-speed centrifuge, H1650-W, Hunan Xiangyi Laboratory Instrument Development Co., Ltd.

[0078] Solution preparation

[0079] Take 0.5 ml of sample and put it in a 2 ml centrifuge tube, add 50% methanol to 1.5 ml, shake well, high-speed centrifugation (12000 r / min) for 5 minutes, take the supernatant, and it is obtained.

[0080] Chromatographic conditions

[0081] Chromatographic column: Waters ACQUITY UPLC HSS T3 (2.1 x 100 mm, 1.8 μm)

[0082] Column temperature: 30℃

[0083] Flow rate: 0.3 ml / min

[0084] Injection volume: 2 μl

[0085] Detection wavelength: 280 nm, 190-400 nm

[0086] Mobile phase ratio: A phase acetonitrile, B phase 0.1% formic acid aqueous solution, gradient see Figure 8 .

[0087] Mass spectrometry conditions

[0088] Mass spectrometry detection mode: ESI-negative / positive ion mode

[0089] Mass spectrometry parameters: see Figure 9.

[0090] Mass spectrometry results

[0091] The compound sample of Wumen Xiantu Jiedu Decoction was analyzed by using ultra-high performance liquid chromatography-high resolution mass spectrometry (UPLC-Q-TOF / MS). According to the mass spectrometry information of the sample, combined with the high resolution mass spectrometry database of natural products and related literature, 91 compounds were identified from the compound sample of Wumen Xiantu Jiedu Decoction.

[0092] The data acquisition software was Analyst TF1.7.1, and the data processing software was Peakview 1.2. During the identification, the mass spectrometry data was matched with the Natural Products HR-MS / MS Spectral Library 1.0 database in priority, the compounds were preliminarily screened according to the score information of each chromatographic peak, and the compounds were further confirmed according to the first and second information of each chromatographic peak. The Natural Products HR-MS / MS Spectral Library 1.0 database collected the mass spectrometry diagrams of the standard samples from the company or other sources, including different acquisition modes, different adduct ions, different collision energies, etc. The compound information was comprehensive, and all the diagrams were the actual acquisition of the standard samples without any simulated diagrams, so the matching result was accurate.

[0093] Preparation of test sample solution

[0094] The blank serum (1.7 ml) and the drug serum (7.5 ml) samples were taken, 3 times of methanol (mass spectrometry grade) was added to precipitate the protein, vortex mixed for 5 minutes, and then placed for 15 minutes (4℃). After centrifugation for 15 minutes (12000 rpm / minute), the supernatant was taken, concentrated and dried by centrifugation, and then placed at-80℃. Before analysis, the residue of the blank serum was redissolved with 0.2 ml of 50% methanol, the residue of the drug serum was redissolved with 0.4 ml of 50% methanol, vortex mixed for 3 minutes, and then centrifuged for 15 minutes (12000 rpm / minute). The supernatant was taken, and the sample was obtained.

[0095] Chromatographic conditions

[0096] Chromatographic column: Waters ACQUITY UPLC HSS T3 (2.1x100 mm, 1.8 μm)

[0097] Column temperature: 30℃

[0098] Flow rate: 0.3 ml / min

[0099] Injection volume: 5 μl

[0100] Detection wavelength: 190-400 nm

[0101] Mobile phase ratio: Phase A acetonitrile, Phase B 0.1% formic acid in water, Figure 13 as shown.

[0102] Mass spectrometry conditions

[0103] Mass spectrometry detection mode: ESI-Negative / Positive ion mode

[0104] Mass spectrometry parameters, Figure 14 as shown.

[0105] Experimental results

[0106] UPLC-HRMS base peak ion chromatogram (BPC) of the soup serum sample - negative ion mode, Figure 15 as shown.

[0107] UPLC-HRMS base peak ion chromatogram (BPC) of the soup serum sample - positive ion mode, Figure 16 as shown.

[0108] UPLC-HRMS extracted ion chromatogram (EIC) of the soup administration serum sample - negative ion mode, Figure 17 as shown.

[0109] UPLC-HRMS extracted ion chromatogram (EIC) of the soup administration serum sample - positive ion mode, Figure 18 as shown.

[0110] Mass spectrometry results

[0111] The soup administration serum sample was analyzed by ultra-high performance liquid chromatography-high resolution mass spectrometry (UPLC-Q-TOF / MS). According to the mass spectrometry information of the sample, combined with the original prescription identification results and related literature, 127 compounds were identified from the administration serum sample, including 42 prototype components and 85 metabolites

[0112]

[0113]

[0114]

[0115]

[0116]

[0117]

[0118]

[0119]

[0120]

[0121]

[0122]

[0123]

[0124]

[0125] Animal experiment results are shown in Figure 7

[0126] has good tumor inhibition effect, and the treatment effect is better after combination with PD1, which shows that the decoction can inhibit tumor growth by enhancing immunotherapy sensitivity, see Figure 7 A-C. WB experiment verification was carried out by collecting clinical samples, and it was found that the expression amount of ELOVL6 protein in normal tissues was significantly higher than that in tumor tissues, see 7D, F. In order to construct overexpression ELOVL6 stable strain in the later stage, background expression experiment was carried out, see Figure 7 E, G;

[0127] A. Body weight of each group before treatment of subcutaneous tumor in vivo pre-experiment; B-C. Compound and combination drug groups can significantly inhibit tumor growth; D, F. WB shows that ELOVL6 is significantly highly expressed in tumor tissues; E, G. Background expression of ELOVL6 in different mouse CRC tumor cell lines.

[0128] The above-described embodiments only express certain embodiments of the present application, which are described in detail and in detail, but should not be understood as limiting the scope of the present patent; it should be pointed out that for ordinary skilled in the art, without departing from the concept of the present application, a number of modifications and improvements can be made, which belong to the protection scope of the present application; therefore, the protection scope of the present patent should be subject to the appended claims.​

Claims

1. A device for decocting traditional Chinese medicine decoctions, characterized in that: include A heating structure (1) is provided with a cooking structure (2) at the top of the heating structure (1), and a top sealing structure (3) is provided at the top of the cooking structure (2). The cooking structure (2) includes a cooking pot (201), a support column (204) is provided in the middle of the cooking pot (201), a side groove (205) is provided on the outer wall of the support column (204) and the inner side of the cooking pot (201), a partition plate (206) is provided between the two side grooves (205), a placement groove (207) is provided inside the partition plate (206), and a diversion groove (208) is provided inside the partition plate (206). The hybrid separation structure (4) includes a lifting chamber (401), a vertical plate (406) is provided at the bottom of the lifting chamber (401), a connecting plate (407) is provided directly below the vertical plate (406), a retaining ring (408) is provided at the top of the connecting plate (407), the retaining ring (408) is engaged with the vertical plate (406), a diversion hole (409) is provided inside the connecting plate (407), and the connecting plate (407) is slidably connected with the diversion groove (208).

2. The herbal decoction preparation device according to claim 1, characterized in that: The heating structure (1) includes a housing (101), an air guide pipe (102) is provided inside the housing (101), a support ring (103) is provided in the middle of the inner wall of the housing (101), and a fitting groove (104) is provided on the outer wall of the housing (101).

3. The traditional Chinese medicine decoction preparation device according to claim 1, characterized in that: The outer wall of the cooking pot (201) is provided with a valve (202), the valve (202) is aligned with the fitting groove (104), and guide screws (203) are rotatably connected to both sides of the inner wall of the cooking pot (201).

4. The traditional Chinese medicine decoction preparation device according to claim 1, characterized in that: The top sealing structure (3) includes a top of a sealing cover (301) rotatably connected to a transmission gear ring (302), a top of the sealing cover (301) rotatably connected to an intermediate gear (303), a top of the sealing cover (301) rotatably connected to an internal gear (308), and the intermediate gear (303) meshing with the internal gear (308) and the transmission gear ring (302).

5. The traditional Chinese medicine decoction preparation device according to claim 4, characterized in that: The number of intermediate gears (303) is set to multiple, and the multiple intermediate gears (303) are arranged in a ring array on the top of the sealing cover (301).

6. The traditional Chinese medicine decoction preparation device according to claim 4, characterized in that: The bottom of the intermediate gear (303) is provided with a rotating shaft (304), the bottom of the rotating shaft (304) is provided with a sealing block (305), the sealing block (305) is configured as a frustum, the bottom of the sealing block (305) is provided with a first spring rod (306), and the outer wall of the first spring rod (306) is provided with a first stirring rod (307).

7. The traditional Chinese medicine decoction preparation device according to claim 4, characterized in that: The bottom of the internal gear (308) is provided with a bottom rod (309), the bottom of the bottom rod (309) is provided with a second spring rod (310), and one end of the bottom of the second spring rod (310) is provided with a second stirring rod (311).

8. The traditional Chinese medicine decoction preparation device according to claim 1, characterized in that: The lifting chamber (401) has mating holes (402) on both sides, which are mated with the guide screw (203). The lifting chamber (401) has a guide ring (403) on its inner side and an auxiliary ring (404) inside. The bottom of the auxiliary ring (404) has a filter barrel (405). The auxiliary ring (404) has a frustum-shaped groove in the middle, and the inner wall of the groove fits against the sealing block (305).

9. The traditional Chinese medicine decoction preparation device according to claim 8, characterized in that: The number of filter barrels (405) is set to multiple, and a first spring rod (306) is provided inside the filter barrel (405).

10. A traditional Chinese medicine decoction formula for use in a traditional Chinese medicine decoction preparation device according to any one of claims 1-9, characterized in that: include The principal herbs are Agrimonia pilosa (30 parts) and Atractylodes macrocephala (15 parts), which have the functions of strengthening the spleen and replenishing deficiency, and addressing the problem of deficiency when pathogenic factors gather. The accompanying ingredients are: 30 parts of *Actinidia chinensis* root, 30 parts of *Scutellaria barbata*, and 15 parts of *Duchesnea indica*, which have the effects of clearing heat and detoxifying, and anti-tumor activity. The adjuvant herbs are 10 parts Curcuma zedoaria and 10 parts Eupolyphaga sinensis, which have the effects of breaking up blood stasis and removing blood stasis caused by prolonged illness. The main ingredients are 15 parts of *Cremastra appendiculata* and 15 parts of *Citrus aurantium*, which have the functions of promoting qi circulation, eliminating phlegm, and treating many diseases caused by phlegm.