Pharmaceutical composition for treating respiratory system diseases and preparation method and device thereof

Abstract

The invention discloses a pharmaceutical composition for treating respiratory system diseases and a preparation method and device thereof. The pharmaceutical composition is efficient, safe, free of toxic and side effects and capable of effectively relieving the respiratory system diseases. The pharmaceutical composition comprises the following components in parts by weight: 1-5 parts of honeysuckle, 0.5-10 parts of raw liquorice, 1-15 parts of pericarpium citri reticulatae, 1-3 parts of radix angelicae, 3-6 parts of pinellia ternate, 0.5-2 parts of folium eriobotryae, 1-2 parts of dandelion, 1-3 parts of astragalus membranaceus, 0.5-3 parts of agastache rugosus, 3-15 parts of mint, 1-3 parts of cedar pine leaves and 0.2-2 parts of hawthorn. The extraction device integrates distillation, decoction and filter pressing. The device provided by the invention is matched with the preparation method, so that the extraction efficiency of Chinese herbal medicines and the extraction rate of effective components can be improved.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical preparation and preparation apparatus, specifically to a pharmaceutical composition for treating respiratory diseases and its preparation method and apparatus. Background Technology

[0002] Respiratory diseases include upper respiratory tract infections, acute tracheobronchitis, chronic bronchitis, chronic obstructive pulmonary disease, bronchial asthma, bronchiectasis, infectious lung diseases, primary bronchogenic carcinoma, interstitial lung disease, pulmonary thromboembolism, pulmonary hypertension, pulmonary heart disease, and pleural diseases.

[0003] Respiratory diseases primarily affect the trachea, bronchi, lungs, and pleural cavity. Patients often present with symptoms such as cough, chest pain, and difficulty breathing. Severe cases can lead to respiratory distress, hypoxia, and even respiratory failure and death. The main causes of these diseases include weakened immune function, autonomic nervous system dysfunction, acidic body constitution, infection, and air pollution.

[0004] Treatment of respiratory diseases primarily depends on the underlying cause and accompanying clinical symptoms. There are relatively many respiratory system diseases, the most common being inflammatory reactions of the respiratory tract, such as bronchitis and pneumonia. Anti-inflammatory drugs can be chosen for treatment. For bacterial infections, antibiotics such as penicillin, amoxicillin, cefoperazone, and levofloxacin can be used. For bronchial asthma, bronchodilators, as well as anti-allergic and anti-inflammatory drugs, can be used, such as budesonide nebulizer solution, salbutamol nebulizer solution, and terbutaline nebulizer solution. For diseases with idiopathic diffuse interstitial fibrosis, glucocorticoids such as dexamethasone, methylprednisolone, and prednisone can generally be chosen, and immunosuppressants such as cyclophosphamide can also be used in combination. Current treatments mostly provide relief, not a cure, and long-term use can lead to drug resistance and side effects. Traditional Chinese medicine has fewer side effects and has certain advantages in treating respiratory diseases. Therefore, providing a highly effective, safe, and non-toxic drug combination for treating respiratory diseases is of great significance. Summary of the Invention

[0005] The purpose of this invention is to provide a pharmaceutical composition for treating respiratory diseases, as well as a method and apparatus for preparing the same, in order to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: This invention provides a pharmaceutical composition for treating respiratory diseases. The pharmaceutical composition of this invention is highly effective, safe, and has no toxic side effects, and can effectively alleviate respiratory diseases. The pharmaceutical composition, by weight, includes 1-5 parts of honeysuckle, 0.5-10 parts of raw licorice, 1-15 parts of dried tangerine peel, 1-3 parts of angelica dahurica, 3-6 parts of pinellia ternata, 0.5-2 parts of loquat leaf, 1-2 parts of dandelion, 1-3 parts of astragalus membranaceus, 0.5-3 parts of agastache rugosa, 3-15 parts of peppermint, 1-3 parts of pine needles, and 0.2-2 parts of hawthorn.

[0007] Furthermore, the aforementioned pharmaceutical composition for treating respiratory diseases comprises, by weight, 5 parts honeysuckle, 4 parts raw licorice root, 3 parts dried tangerine peel, 2 parts angelica dahurica, 5 parts pinellia ternata, 1 part loquat leaf, 2 parts dandelion, 3 parts astragalus membranaceus, 3 parts agastache rugosa, 6 parts peppermint, 2 parts pine needles, and 1 part hawthorn.

[0008] This invention also provides a method for preparing a pharmaceutical composition for treating respiratory diseases. The apparatus provided by this invention, combined with the preparation method, can improve the extraction efficiency and extraction rate of active ingredients from traditional Chinese medicine. The preparation method includes the following steps: Weigh out the following ingredients according to the weight proportions specified in claim 1 or claim 2: honeysuckle, raw licorice root, dried tangerine peel, angelica root, pinellia tuber, loquat leaf, dandelion, astragalus root, patchouli, mint, pine needles, and hawthorn, then pulverize them into particles of 0.1-0.5 cm and mix them to obtain Chinese medicine granules. Add the above-mentioned Chinese herbal granules to the Chinese herbal extraction device, steam for 0.5 hours, then soak the Chinese herbal granules in 15-20 times the amount of water, soak for 1-2 hours, heat up, decoct for 3-5 hours, filter under pressure to obtain a first decoction. Add 10-12 times the amount of water to the Chinese herbal medicine granules, heat up, decoct for 2-3 hours, filter under pressure to obtain the second decoction; The decoction from the first and second decoctions are combined and concentrated to obtain a clear extract. The clear extract is dried and pulverized to obtain a traditional Chinese medicine powder. An acceptable pharmaceutical carrier is added to obtain a pharmaceutical composition for treating respiratory diseases.

[0009] Furthermore, the traditional Chinese medicine extraction device includes: a base plate fixed to the ground, an outer cylinder on the base plate, a temperature control device outside the outer cylinder, a drain outlet at the bottom of the outer cylinder, an inner cylinder inside the outer cylinder, a mesh plate at the bottom of the inner cylinder, a support ring plate at the top of the inner cylinder, multiple hydraulic rods between the support ring plate and the base plate, and a sealing mechanism above the support ring plate.

[0010] Further, the sealing mechanism includes: a sealing ring plate matched with the support ring plate; a first support vertical plate and a second support vertical plate are arranged opposite to each other on the sealing ring plate; the first support vertical plate and the second support vertical plate are connected by a first support horizontal plate and a second support horizontal plate; a driving gear, a first driven gear, and a second driven gear are arranged between the first support horizontal plate and the second support horizontal plate; the driving gear and the first driven gear mesh; the first driven gear and the second driven gear mesh; the driving gear is connected to a motor through a first rotating shaft; the first driven gear is placed on the second rotating shaft; the second rotating shaft is fixed between the first support horizontal plate and the second support horizontal plate; a lifting screw is arranged inside the second driven gear; the lifting screw passes through the first support horizontal plate and the second support horizontal plate; the driving gear is driven by the first driven gear to rotate; the first driven gear is driven by the first driven gear to rotate. The rotation of the second driven gear drives the lifting screw to move up and down. A positioning plate is provided at the top of the lifting screw, and a filter plate is fixedly connected to the bottom of the lifting screw through the sealing plate. The through hole on the sealing plate is slightly larger than the diameter of the lifting screw. The sealing plate is provided with an inlet and an outlet. The inlet is used to add water, and the outlet is used to pump out the decoction. An outlet pipe is installed inside the outlet. Multiple connecting rods are provided on the upper surface of the filter plate. The inlet port of the outlet pipe is in contact with the filter plate. The outlet pipe is a telescopic pipe to pump out the filtrate as completely as possible. The outlet pipe is connected to a pump. The diameter of the sealing plate and the filter plate is the same as the inner diameter of the inner cylinder to facilitate sealing. The up and down movement of the lifting screw drives the up and down movement of the filter plate. The filter plate moves down to filter the decocted Chinese herbal medicine, reducing the residue of the Chinese herbal extract.

[0011] Furthermore, the filter press plate is a mesh plate, which facilitates the separation of the filtrate from the traditional Chinese medicine.

[0012] Furthermore, the lower surface edge of the sealing plate is uniformly provided with multiple first limiting grooves, and the inner cylinder is provided with limiting blocks that match the first limiting grooves. The first limiting grooves and limiting blocks are provided so that the sealing plate is locked in the top of the inner cylinder, sealing the inner cylinder. The edge of the filter press plate is provided with a second limiting groove, and the inner wall of the inner cylinder is provided with a limiting strip that matches the second limiting groove. The second limiting groove and limiting strip prevent the filter press plate from rotating, indirectly limiting the lifting screw and preventing the lifting screw from rotating with the second driven gear, thus ensuring the up and down movement of the lifting screw and the up and down movement of the filter press plate.

[0013] Furthermore, the support ring plate is bolted to the sealing ring plate, which facilitates sealing and separation, and makes cleaning easier.

[0014] Compared with the prior art, the beneficial effects of the present invention are: This invention relates to a pharmaceutical composition for treating respiratory diseases, which is highly effective, safe, and has no toxic side effects, and can effectively alleviate respiratory diseases.

[0015] The present invention discloses a method for preparing a pharmaceutical composition for treating respiratory diseases. Based on a traditional Chinese medicine extraction device, the herbal granules are placed in an inner cylinder, and the herbal medicine is first distilled. Then, the inner cylinder is lowered to the bottom of the outer cylinder by a hydraulic rod, and then water is added through the inlet for soaking. The temperature is then raised and decocted by a temperature control device. After decocting, the motor is started to drive the drive gear to rotate. Through the transmission of the first driven gear, the second gear rotates, thereby gradually lowering the lifting screw, thereby lowering the filter plate and stretching the water outlet pipe. The liquid pump is then started to pump out the decoction. The extraction device of the present invention integrates distillation, decoction, and pressure filtration, which increases the extraction efficiency and extraction yield during the preparation of the pharmaceutical composition. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of the herbal medicine extraction device of the present invention; Figure 2 This is a schematic diagram of the structure of the sealing plate and filter press plate of the present invention; Figure 3 This is a structural diagram of the content.

[0017] Explanation of reference numerals in the attached figures In the diagram: 1. Base plate; 2. Temperature control device; 3. Inner cylinder; 4. Hydraulic rod; 5. Sealing ring plate; 6. Support ring plate; 7. First support vertical plate; 8. Second support vertical plate; 9. First support horizontal plate; 10. Second support horizontal plate; 11. Motor; 12. Drive gear; 13. First driven gear; 14. Second driven gear; 15. Lifting screw; 16. Positioning plate; 17. Sealing plate; 18. Inlet; 19. Outlet; 20. Filter press plate; 21. Connecting rod; 22. First limiting groove; 23. Second limiting groove; 24. Limiting strip; 25. Limiting block. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Example 1

[0019] A pharmaceutical composition for treating respiratory diseases, comprising, by weight, 5 parts honeysuckle, 4 parts raw licorice root, 3 parts dried tangerine peel, 2 parts angelica root, 5 parts pinellia tuber, 1 part loquat leaf, 2 parts dandelion, 3 parts astragalus root, 3 parts patchouli, 6 parts peppermint, 2 parts pine needles, and 1 part hawthorn.

[0020] The preparation method of the above-described pharmaceutical composition for treating respiratory diseases includes the following steps: Weigh out the following ingredients according to the weight proportions mentioned above: honeysuckle, raw licorice root, dried tangerine peel, angelica root, pinellia tuber, loquat leaf, dandelion, astragalus root, patchouli, mint, pine needles, and hawthorn. Then pulverize them into particles of 0.1-0.5cm and mix them to obtain Chinese medicine granules. Add the above-mentioned Chinese herbal granules to the Chinese herbal extraction device, steam for 0.5 hours, then soak the Chinese herbal granules in 15 times the amount of water, soak for 2 hours, heat up, decoct for 4 hours, filter under pressure to obtain a first decoction. Add 10 times the amount of water to the Chinese herbal medicine granules, heat up, decoct for 3 hours, filter, and obtain the second decoction. (4) After combining the first decoction and the second decoction, the concentrated extract is obtained. The extract is dried and pulverized to obtain Chinese medicine powder. An acceptable pharmaceutical carrier is added to obtain a drug composition for treating respiratory diseases. Example 2

[0021] A pharmaceutical composition for treating respiratory diseases, comprising, by weight, 2 parts honeysuckle, 8 parts raw licorice root, 10 parts dried tangerine peel, 3 parts angelica root, 3 parts pinellia tuber, 2 parts loquat leaf, 1 part dandelion, 2 parts astragalus root, 2 parts agastache rugosa, 10 parts peppermint, 3 parts pine needles, and 2 parts hawthorn.

[0022] The same method as in Example 1 was used to prepare a pharmaceutical composition for treating respiratory diseases. Example 3

[0023] A pharmaceutical composition for treating respiratory diseases, comprising, by weight, 1 part honeysuckle, 0.5 parts raw licorice root, 15 parts dried tangerine peel, 1 part angelica dahurica, 6 parts pinellia ternata, 0.5 parts loquat leaf, 2 parts dandelion, 3 parts astragalus membranaceus, 3 parts agastache rugosa, 8 parts peppermint, 3 parts pine needles, and 0.5 parts hawthorn.

[0024] The same method as in Example 1 was used to prepare a pharmaceutical composition for treating respiratory diseases. Example 4

[0025] The traditional Chinese medicine extraction device includes: a base plate fixed to the ground, an outer cylinder on the base plate, a temperature control device outside the outer cylinder, and a drain outlet at the bottom of the outer cylinder (not shown in the figure); an inner cylinder is fitted inside the outer cylinder, the bottom of the inner cylinder is a mesh plate, a support ring plate is provided at the top of the inner cylinder, multiple hydraulic rods are provided between the support ring plate and the base plate, and a sealing mechanism is provided above the support ring plate.

[0026] The sealing mechanism includes: a sealing ring plate matched with a support ring plate; the support ring plate and the sealing ring plate are bolted together; a first support vertical plate and a second support vertical plate are arranged opposite each other on the sealing ring plate; the first support vertical plate and the second support vertical plate are connected by a first support horizontal plate and a second support horizontal plate; a driving gear, a first driven gear, and a second driven gear are arranged between the first support horizontal plate and the second support horizontal plate; the driving gear and the first driven gear mesh; the first driven gear and the second driven gear mesh; the driving gear is connected to a motor through a first rotating shaft; the first driven gear is placed on a second rotating shaft; the second rotating shaft is fixed between the first support horizontal plate and the second support horizontal plate; a lifting screw is arranged inside the second driven gear; the lifting screw passes through the first support horizontal plate and the second support horizontal plate; the driving gear drives the first driven gear to rotate; the first driven gear drives the second driven gear to rotate. The rotation of the second driven gear drives the lifting screw to rise and fall. A positioning plate is set on the top of the lifting screw, and a filter plate is fixedly connected to the bottom of the lifting screw through the sealing plate. The through hole on the sealing plate is slightly larger than the diameter of the lifting screw. The sealing plate is equipped with an inlet and an outlet. The inlet is used to add water, and the outlet is used to pump out the decoction. An outlet pipe is installed in the outlet. Multiple connecting rods are set on the upper surface of the filter plate. The inlet port of the outlet pipe is in contact with the filter plate (the inlet port and the filter plate are not sealed, so the liquid can be drawn into the outlet pipe). The outlet pipe is a telescopic pipe to pump out the filtrate as completely as possible. The outlet pipe is connected to a pump. The diameter of the sealing plate and the filter plate is the same as the inner diameter of the inner cylinder. The up and down movement of the lifting screw drives the up and down movement of the filter plate. The filter plate moves down to filter the decocted Chinese herbal medicine. The filter plate is a mesh plate.

[0027] Multiple first limiting grooves are evenly arranged on the lower surface edge of the sealing plate, and a limiting block matching the first limiting groove is provided on the inner cylinder. The arrangement of the first limiting groove and the limiting block causes the sealing plate to be locked in the top of the inner cylinder, thus sealing the inner cylinder. The edge of the filter press plate is provided with a second limiting groove, and a limiting strip matching the second limiting groove is provided on the inner wall of the inner cylinder.

[0028] Working principle: Water is added through the inlet, and the herbal granules are placed in the inner cylinder. The herbal medicine is first distilled, and the water used for distillation is discharged. Then, the inner cylinder is lowered to the bottom of the outer cylinder by a hydraulic rod. Then, the appropriate amount of water is added through the inlet for soaking (in a specific embodiment of the invention, the water may include the hot water discharged from distillation). Then, the temperature is raised and decocted by a temperature control device. After decocting, the motor is started to drive the drive gear to rotate. Through the first driven gear, the second gear rotates, thereby gradually moving the lifting screw downward, thereby moving the filter plate downward and stretching the water outlet pipe. The liquid pump is started to pump out the decoction. The lifting screw moves upward, moving the filter plate upward. Water is added again for a second decoction, and then the filter is pressed again. The liquid pump is started to pump out the decoction. When cleaning is required, the lifting screw continues to move upward, moving the sealing plate upward until it is removed from the inner cylinder. Cleaning can be done without disassembly. The extraction device of the present invention integrates distillation, decoction, and filtration, which increases the extraction efficiency and extraction yield during the preparation of drug compositions.

[0029] The pharmaceutical compositions prepared in Examples 1-3 were subjected to clinical trials: Two hundred patients with respiratory diseases were selected and divided into four groups. Three groups were treated with the drug composition of Example 1, Example 2 or Example 3, respectively. The other group was the control group and was treated with saline. The dosage was 2g twice a day, taken orally, for 14 days as one course of treatment. The specific efficacy is shown in Table 1.

[0030] Efficacy evaluation criteria: Significant effect: No cough or breathing obstruction after one course of treatment; Effective: Coughing and breathing difficulties were reduced after one course of treatment, and there were no coughing or breathing difficulties after two courses of treatment; Ineffective: Coughing and breathing difficulties did not improve after one course of treatment.

[0031] Table 1 Comparison of therapeutic effects

[0032] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0033] It should be noted that the above content merely illustrates the technical concept of the present invention and should not be construed as limiting the scope of protection of the present invention. For those skilled in the art, various improvements and modifications can be made without departing from the principle of the present invention, and all such improvements and modifications fall within the scope of protection of the claims of the present invention.

Claims

1. A pharmaceutical composition for treating respiratory diseases, characterized in that, By weight, it includes 1-5 parts honeysuckle, 0.5-10 parts raw licorice, 1-15 parts dried tangerine peel, 1-3 parts angelica dahurica, 3-6 parts pinellia, 0.5-2 parts loquat leaf, 1-2 parts dandelion, 1-3 parts astragalus, 0.5-3 parts agastache, 3-15 parts peppermint, 1-3 parts pine needles, and 0.2-2 parts hawthorn.

2. The pharmaceutical composition for treating respiratory diseases according to claim 1, characterized in that, By weight, it includes 5 parts honeysuckle, 4 parts raw licorice root, 3 parts dried tangerine peel, 2 parts angelica root, 5 parts pinellia tuber, 1 part loquat leaf, 2 parts dandelion, 3 parts astragalus root, 3 parts patchouli, 6 parts peppermint, 2 parts pine needles, and 1 part hawthorn.

3. A method for preparing a pharmaceutical composition for treating respiratory diseases, characterized in that, Includes the following steps: (1) Weigh out the following ingredients according to the weight proportions described in claim 1 or claim 2: honeysuckle, raw licorice, tangerine peel, angelica, pinellia, loquat leaf, dandelion, astragalus, patchouli, mint, pine needles, and hawthorn, then pulverize them into particles of 0.1-0.5 cm and mix them to obtain Chinese medicine granules; (2) Add the above Chinese medicine granules to the Chinese medicine extraction device, steam for 0.5 hours, then soak the Chinese medicine granules in 15-20 times the amount of water, soak for 1-2 hours, heat up, decoct for 3-5 hours, filter under pressure to obtain a first decoction. (3) Add 10-12 times the amount of water to the Chinese herbal medicine granules, heat up, decoct for 2-3 hours, filter under pressure to obtain the second decoction; (4) After combining the first decoction and the second decoction, the concentrated extract is obtained. The extract is dried and pulverized to obtain Chinese medicine powder. An acceptable pharmaceutical carrier is added to obtain a drug composition for treating respiratory diseases.

4. The method for preparing a pharmaceutical composition for treating respiratory diseases according to claim 3, characterized in that, The herbal medicine extraction device includes: a base plate fixed to the ground, an outer cylinder on the base plate, a temperature control device outside the outer cylinder, a drain outlet at the bottom of the outer cylinder, an inner cylinder inside the outer cylinder, a mesh plate at the bottom of the inner cylinder, a support ring plate at the top of the inner cylinder, multiple hydraulic rods between the support ring plate and the base plate, and a sealing mechanism above the support ring plate.

5. The method for preparing a pharmaceutical composition for treating respiratory diseases according to claim 4, characterized in that, The sealing mechanism includes: a sealing ring plate matched with the support ring plate; a first support vertical plate and a second support vertical plate are arranged opposite each other on the sealing ring plate; the first support vertical plate and the second support vertical plate are connected by a first support horizontal plate and a second support horizontal plate; a driving gear, a first driven gear and a second driven gear are arranged between the first support horizontal plate and the second support horizontal plate; the driving gear and the first driven gear mesh; the first driven gear and the second driven gear mesh; the driving wheel is connected to a motor through a first rotating shaft; the first driven wheel is placed on a second rotating shaft; the second rotating shaft is fixed between the first support horizontal plate and the second support horizontal plate; a lifting screw is arranged inside the second driven gear; the lifting screw passes through the first support horizontal plate and the second support horizontal plate; a positioning plate is arranged at the top of the lifting screw; a filter press plate is fixedly connected to the bottom of the lifting screw through the sealing plate; an inlet and an outlet are arranged on the sealing plate; and the sealing plate is placed at the top of the inner cylinder.

6. The method for preparing a pharmaceutical composition for treating respiratory diseases according to claim 5, characterized in that, The filter press plate is a mesh plate.

7. The method for preparing a pharmaceutical composition for treating respiratory diseases according to claim 5, characterized in that, The lower surface edge of the sealing plate is uniformly provided with a plurality of first limiting grooves, the inner cylinder is provided with a limiting block that matches the first limiting grooves, the edge of the filter press plate is provided with a second limiting groove, and the inner wall of the inner cylinder is provided with a limiting strip that matches the second limiting groove.

8. A method for preparing a pharmaceutical composition for treating respiratory diseases according to claim 5, characterized in that, The support ring plate is bolted to the sealing ring plate.

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