Dual-power drug delivery device

Abstract

The invention relates to a dual-power dosing device which comprises a shell, a valve assembly, a spray head, a retainer and a counting assembly, and the shell comprises a nose socket, an air blowing port and an air flow channel communicating the air blowing port with the nose socket; the valve assembly is at least used for opening the airflow channel; the spray head is provided with a spraying channel leading to the nose socket and can move relative to the shell; the retaining piece is used for driving a medicine bottle containing medicine to move relative to the shell, and a pump assembly is arranged on the medicine bottle; the counting assembly comprises a counting screw rod which is rotatably mounted on the shell and a counting indicator which is in threaded connection with the counting screw rod; the holder is capable of driving the vial and pump assembly to move toward the nose socket. In the upward moving process of the retaining piece, spraying can be achieved, the spraying head, the valve assembly and the counting screw rod can be in linkage, the linkage mode can simplify operation of the dual-power dosing device, and user experience is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical drug delivery devices, in particular to a double-power drug delivery device. BACKGROUND

[0002] Nasal drug delivery system refers to the drug entering the nasal cavity through the nasal mucosa epithelial cells into the circulatory system, thereby treating systemic or local diseases. The current common dosage forms include nasal drops, powder / gas / spray, gel, and nasal wash. Studies have shown that nasal drug delivery can bypass the blood-brain barrier and avoid the blocking of active drug molecules, thereby reducing bioavailability and affecting drug efficacy. Due to its convenience, high efficiency, and non-invasive nature, it has become a research hotspot at home and abroad and is increasingly widely used in the medical field.

[0003] The droplet size is a key parameter for evaluating the atomization effect. The Sauter mean diameter (SMD) refers to the diameter of the droplet, which is the ratio of the volume and surface area of all droplets in the spray. When the total volume of the droplets remains unchanged, the smaller the SMD, the larger the total surface area of the droplets, and the better the atomization effect.

[0004] The existing double-power drug delivery device is inserted into the nasal cavity during use, the middle finger is buckled to hold the device, and the thumb is pressed to trigger the pump assembly to atomize the liquid into the nasal cavity. Commonly, the double-power drug delivery device is an injection molding part, which is affected by the injection mold. The outlet diameter of the nozzle has a lower limit, generally about 0.3 mm, and the precision is about ±0.05 mm. In addition, the injection molding part is affected by temperature, humidity, pressure, material, and other factors, which leads to fluctuations and batch problems in the outlet diameter of the nozzle. Existing papers and journals have determined the atomization effect of the cyclone atomization, which is greatly affected by the length-diameter ratio (diameter to height ratio) of the nozzle and the liquid flow rate.

[0005] The existing double-power drug delivery device is single-powered, and the power source is the force of the finger pressing. The power of each time is greatly affected by the force and speed of different patients, leading to inconsistent liquid flow rate and affecting the final atomization effect. At the same time, patients have different habits of use and operation, and the position of the nozzle inserted into the nasal cavity is also different, leading to different deposition positions of the atomized liquid. If the patient inserts shallowly, the liquid is deposited in the vestibule of the nasal cavity, which has no absorption function. If the patient inserts deeply, the liquid enters the airway or esophagus through the soft palate of the oral cavity, affecting the drug efficacy and causing other adverse reactions.

[0006] Although some dual-power drug delivery devices can improve atomization effect by airflow assistance, the opening and closing control of the spray and airflow channels is relatively complex. Moreover, such dual-power drug delivery devices cannot easily grasp the remaining dose in the drug bottle, which may lead to false medication. If a counting function is added to the dual-power drug delivery device, not only the structural complexity of the device is increased, but also how to coordinate the opening and closing of the spray, airflow channels and counting is a difficult problem. SUMMARY

[0007] To solve at least one technical problem in the background counting, an embodiment of the present application provides a dual-power drug delivery device.

[0008] To achieve the above-mentioned purpose, an embodiment of the present application provides the following technical solutions: An embodiment of the present application provides a dual-power drug delivery device, which comprises: A housing comprising a nosepiece, an air blowing port and an airflow channel communicating the air blowing port and the nosepiece; A valve assembly for opening at least the airflow channel; A spray head having a spray channel leading to the nosepiece and being movable relative to the housing; A retaining member for moving a drug bottle containing a drug relative to the housing, the drug bottle being provided with a pump assembly; the pump assembly can extract the drug in the drug bottle and spray the drug out of the nosepiece through the spray channel; A counting assembly comprising a counting screw and a counting indicator threadedly connected to the counting screw, the counting screw being rotatably mounted on the housing; The retaining member can move the drug bottle and the pump assembly towards the nosepiece; wherein the movement of the retaining member can trigger drug spraying, the movement of the pump assembly can move the spray head towards the nosepiece before the drug bottle sprays, the movement of the retaining member or the spray head can move the valve assembly to an open position, and the movement of the retaining member can rotate the counting screw.

[0009] Optionally, the housing further comprises a limiting structure, when the spray head moves towards the nosepiece to the limiting structure, the limiting structure hinders the spray head from continuing to move, and the retaining member can continue to move the pump assembly relative to the spray head towards the nosepiece to trigger the pump assembly to spray the drug.

[0010] Optionally, the valve assembly comprises a valve core, a valve switch and a force diversion structure. The force conversion structure is configured to convert the axial movement of the nozzle or the retaining member into a movement of the valve switch in a first preset direction, which can open or close the airflow passage; wherein the first preset direction is not parallel to the axial direction.

[0011] Optionally, the valve core comprises an elastic membrane provided with a gap, the movement of the valve switch can cover the gap, and the elastic membrane can tightly adhere to the valve switch by its elasticity to close the airflow passage. The movement of the valve switch can also separate the valve switch from the elastic membrane, and the airflow from the blowing port can deform the elastic membrane to increase the gap, thereby opening the airflow passage.

[0012] Optionally, the force conversion structure comprises a valve connecting rod, one end of the valve connecting rod is pivotally connected to the nozzle or the retaining member, and the other end of the valve connecting rod is pivotally connected to the valve switch.

[0013] Optionally, the housing is provided with a track extending in the first preset direction, and the valve switch moves along the track.

[0014] Optionally, the valve core comprises an elastic membrane provided with a gap, and the elastic membrane can close the gap by its elasticity. The valve switch can separate the elastic membrane to allow the valve assembly to conduct the blowing port and the nosepiece through the gap.

[0015] Optionally, the force conversion structure comprises a first brake inclined surface provided on the retaining member or the nozzle, and a second brake inclined surface provided on the valve switch, the first brake inclined surface abuts against the second brake inclined surface; when the retaining member or the nozzle moves towards the nosepiece, the first brake inclined surface can move in abutment with the second brake inclined surface to move the valve switch from an initial position to a position for separating the elastic membrane.

[0016] Optionally, the valve assembly further comprises an elastic member, which can drive the valve switch to return to a position for closing the valve core.

[0017] Optionally, the retaining member is provided with a driving protrusion, the driving protrusion has a counting inclined surface, the counting screw is provided with a transmission protrusion, the transmission protrusion has a transmission inclined surface, and when the retaining member moves, the counting inclined surface can move in abutment with the transmission inclined surface to rotate the counting screw about its axis.

[0018] Optionally, the counting screw is provided with a plurality of transmission protrusions along its circumference, and the driving protrusion comprises a first protrusion and a second protrusion. When the retaining member is static relative to the housing, the first protrusion is located in the interval space between two adjacent transmission protrusions to hinder the rotation of the counting screw; when the retaining member moves relative to the housing, the first protrusion can move out of the interval space, and the counting slope of the second protrusion can be in contact with the transmission slope to move, so as to rotate the counting screw; or, When the retaining member is static relative to the housing, the second protrusion is located in the interval space between two adjacent transmission protrusions to hinder the rotation of the counting screw; when the retaining member moves relative to the housing, the second protrusion can move out of the interval space, and the counting slope of the first protrusion can be in contact with the transmission slope to move, so as to rotate the counting screw.

[0019] Optionally, the dual-power drug delivery device further comprises a manual trigger, the manual trigger is connected with the retaining member through a wedge mechanism, and the wedge mechanism can convert the force of moving the manual trigger in a first preset direction into the force of moving the retaining member in the axial direction.

[0020] Optionally, the wedge mechanism comprises a first trigger slope on the manual trigger and a second trigger slope on the retaining member, and the first trigger slope is in contact with the second trigger slope.

[0021] Optionally, the wedge mechanism comprises a first trigger slope on one of the manual trigger and the retaining member and a curved surface on the other, and the first trigger slope is in line contact with the curved surface.

[0022] Optionally, the manual trigger is used to trigger the retaining member to move towards the nosepiece, the manual trigger is mounted on the housing, and the manual trigger comprises a plurality of finger placement portions.

[0023] The embodiments of the present application have at least the following technical effects: During the upward movement of the retaining member, not only can the spraying be realized, but also the spray head, the valve assembly and the counting screw can be linked and moved, and such linkage can not only simplify the operation of the dual-power drug delivery device and improve the user experience, but also can effectively ensure the coordination of the spraying, the airflow assistance and the counting.

[0024] During the upward movement of the retaining member, the spray head also moves towards the nosepiece, so that the atomization starting point of the liquid medicine can further enter the nasal cavity, the medicine delivery is more in-depth, and the atomized medicine can be prevented from adhering to the inner wall of the nosepiece to cause pollution and waste.

[0025] The remaining dose can be more accurately determined by the scale indicated by the counter. If the remaining dose in the vial is less than the amount needed for one dose, the patient can be informed promptly and accurately, reducing or even avoiding false medication use. Attached Figure Description

[0026] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0027] Figure 1 This is a schematic diagram of the structure of a dual-powered drug delivery device provided in some embodiments of this application; Figure 2 This is a longitudinal sectional view of the dual-power drug delivery device of some embodiments of this application before spraying; Figure 3 for Figure 2 A schematic diagram of the structure of a dual-powered drug delivery device during spraying; Figure 4 This is a schematic diagram of the counting component in the initial state of a dual-powered drug delivery device according to some embodiments of this application; Figure 5 for Figure 4 A schematic diagram of the counting component in the dual-power drug delivery device at the end of the spray cycle; Figure 6 Showing Figure 1 A schematic diagram of the first type of valve assembly in a dual-power drug delivery device; Figure 7 for Figure 6 Schematic diagram of the middle valve core; Figure 8 for Figure 6 Schematic diagram of the structure of the central valve switch; Figure 9 for Figure 1 A schematic diagram of the structure of a Chinese medicine bottle cap; Figure 10 This is a schematic diagram of the structure of the second type of valve assembly in the dual-power drug delivery device of some embodiments of this application; Figure 11 for Figure 11 Schematic diagram of the middle valve core; Figure 12 for Figure 11 Schematic diagram of the structure of the central valve switch; Figure 13 To and Figure 11 A schematic diagram of the bottle cap structure matched with the second type of valve assembly; Figure 14This is a cross-sectional view of a dual-power drug delivery device according to other embodiments of this application before spraying; wherein, the valve assembly of the dual-power drug delivery device is... Figure 10 The valve assembly shown; Figure 15 for Figure 14 Cross-sectional view of the dual-power drug delivery device during spraying; Figure 16 for Figure 1 A schematic diagram of the retainer engaging with the medicine bottle in its initial state; Figure 17 This is a schematic diagram showing the structure of the retainer engaging with the medicine bottle after the button is pressed. Figure 18 for Figure 1 A schematic diagram of the left shell in a dual-powered drug delivery device; Figure 19 for Figure 1 A schematic diagram of the right shell in a dual-power drug delivery device; Figure 20 A schematic diagram of a dual-powered drug delivery device with a protective cap; Figure 21 This is a schematic diagram of the manual trigger element in some embodiments of the dual-power drug delivery device of this application; Figure 22 This is a schematic diagram of the structure of the retainer in the initial state of the dual-power drug delivery device according to some embodiments of this application, in which the retainer engages with the medicine bottle; wherein the retainer has a generally elliptical cylindrical boss.

[0028] Explanation of reference numerals in the attached figures: 1. Housing; 100. Airflow channel; 2. Mouth support; 21. Mouth support core; 211. Core cylinder; 212. Support rib; 22. Air inlet; 23. Mouth support channel; 3. Nose support; 31. Nose support opening; 4-a / 4-b. Valve assembly; 41-a / 41-b. Valve core; 411-a / 411-b. Gap; 412-a / 412-b. Elastic membrane; 413. Inlet end; 414. Outlet end; 42-a / 42-b. Valve switch; 421-a / 421-b. Valve boss; 422. First pivot part; 423. Notch; 424. Second braking slope; 43. Valve connecting rod; 431. Pivoting boss; 5. Nozzle; 51. Nozzle body; 512. Shoulder; 513. Injection Channel; 6. Left Shell; 61. Counting Window; 611. Upper Limit Surface; 612. Lower Limit Surface; 62. Support Platform; 63. Screw Fixing Position; 64. Rail; 65. Connecting Boss; 68. Thumb Position; 69. Limiting Structure; 7. Right Shell; 74. External Dustproof Platform; 75. Internal Dustproof Platform; 8. Manual Trigger; 81. Finger Placement; 82. Hook; 83. First Trigger Angled Surface; 9. Sealing Ring; 10. Counting Assembly; 101. Counting Screw; 1011. External Thread; 1012. First Angled Surface; 1013. Second Angled Surface; 1014. Transmission Protrusion; 1 02. Counting indicator; 1021. Indicating boss; 11. Retainer; 111. Bottle cap; 1112. First braking ramp; 151. Protrusion; 1151. Second trigger ramp; 112. Bottle; 113. Bottle base; 1132. First counting ramp; 1133. Second counting ramp; 1134. First protrusion; 1135. Second protrusion; 1136. First retaining surface; 1137. Second retaining surface; 114. Pump assembly; 1141. Metering valve; 1142. Suction tube; 13. Protective cap; 14. Shell body; 141. Inner cavity; 161. Elliptical cylindrical boss; 1611. Curved surface. Detailed Implementation

[0029] To make the technical solution and beneficial effects of the present invention more apparent and understandable, a detailed description is provided below by listing specific embodiments. The accompanying drawings are not necessarily drawn to scale, and local features may be enlarged or reduced to more clearly show the details of the local features; unless otherwise defined, the technical and scientific terms used herein have the same meanings as those in the technical field to which this application pertains.

[0030] In the description of this invention, the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "height," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the purpose of simplifying the description of this invention and do not indicate that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. That is, they should not be construed as limiting this invention.

[0031] In this invention, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating the relative importance of the indicated features or the number of indicated technical features. Therefore, a feature specified as "first" or "second" can explicitly include at least one of that feature. In the description of this invention, "a plurality of" means at least two, such as two, three, etc.; "several" means at least one, such as one, two, three, etc., unless otherwise explicitly specified.

[0032] In this invention, unless otherwise explicitly defined, the terms "installation," "connection," "linking," "fixing," and "setting," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral part; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can also refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0033] In this invention, unless otherwise explicitly defined, the terms "above," "on top of," "over," "above," "below," "below," "below," or "below" for "first feature above second feature" can refer to the first and second features being in direct contact, or to the first and second features being in indirect contact through an intermediate medium. Furthermore, "above," "over," and "below" for "first feature above second feature" can mean the first feature is directly above or diagonally above the second feature, or simply indicates that the horizontal height of the first feature is higher than the horizontal height of the second feature. Similarly, "below," "below," and "below" for "first feature below second feature" can mean the first feature is directly below or diagonally below the second feature, or simply indicates that the horizontal height of the first feature is lower than the horizontal height of the second feature.

[0034] Figures 1 to 22 Examples illustrate the overall structure and some components of the nose support device in some embodiments of this application.

[0035] See Figure 1The dual-powered drug delivery device includes a housing 1, which includes a nose inlet 31, an air outlet 22, and an airflow channel 100 connecting the air outlet 22 and the nose inlet 31. Figure 3 The airflow enters through the air inlet 22 and is guided through the airflow channel 100 to the nasal inlet 31, from which it is sprayed into the nasal cavity. The airflow blown in from the air inlet 22 can flow through the airflow channel 100 toward the nasal inlet 31, providing assistance to the sprayed droplets and helping to carry the liquid medicine into the olfactory and respiratory areas of the nasal cavity as much as possible. Moreover, the air blown out of the mouth can provide shear force to assist in the atomization of the liquid medicine, thereby making the liquid medicine atomized more thoroughly, obtaining smaller particle sizes, and achieving better effects.

[0036] exist Figure 1 In the illustrated implementation, the housing 1 includes a housing body 14 and a receiving port 2 connected to the housing body. A nose support 3 is formed on the top of the housing body, and the nose support 3 has a nose support opening 31. The receiving port 2 extends laterally from the side wall of the housing body and has a receiving port channel 23. Figure 2 The mouth-holding channel 23 has an air inlet 22 at one end and is connected to the nose-holding port 31 through the airflow channel 100 at the other end. The air inlet 22 is on the side and the nose-holding port 31 is on top, which makes it easier to align with the mouth and nose during use.

[0037] See Figure 2 and Figure 3 ,as well as Figure 14 and Figure 15 The dual-powered drug delivery device also includes valve assemblies 4-a / 4-b, which are used to open the airflow passage 100 at least.

[0038] exist Figure 2 and Figure 3 ,as well as Figure 16 and Figure 17 In both implementations shown, valve assemblies 4-a / 4-b are located at the connection between the bearing 2 and the housing body, and are situated to the side of the housing body's axis. The valve assemblies 4-a / 4-b can open or close the fluid passage by changing their position during movement.

[0039] See also Figure 2 and Figure 3 The dual-powered drug delivery device also includes a nozzle 5, which has a spray channel 513 leading to the nasal inlet 31, through which the drug is sprayed into the nasal cavity. The aforementioned airflow channel 100 is located between the outer wall of the nozzle 5 and the housing body, and surrounds the spray channel 513.

[0040] The dual-powered drug delivery device also includes a retainer 11, which can move the medicine bottle containing the medicine relative to the housing 1. Here, the retainer 11 can serve as a mounting carrier for the medicine bottle 112, which is equipped with a pump assembly 114 connected to the nozzle 5; the pump assembly 114 and the nozzle 5 work together to achieve spraying. For example, when the pump assembly 114 moves relative to the nozzle 5 toward the nose socket 31 (i.e., upwards), the nozzle 5 can activate the pump assembly 114, which can then spray the medicine through the spray channel 513 out of the nose socket 31. After spraying, the pump assembly 114 can extract the medicine needed for the next spray from the medicine bottle 112.

[0041] See also Figure 2 and Figure 3 The dual-power drug delivery device also includes a counting assembly 10, which includes a counting screw 101 and a counting indicator 102 threadedly connected to the counting screw 101. The counting screw 101 is rotatably mounted on the housing 1. When the counting screw 101 rotates, the counting indicator 102 can move along the axial direction of the counting screw 101.

[0042] See Figure 1 The housing 1 is equipped with a counting window 61, through which the counting indicator 102 can be observed, and the remaining dose of the medicine bottle 112 can be determined according to the indication of the counting indicator 102. The remaining dose is visualized, eliminating the need to distinguish the liquid level of the medicine with the naked eye, making it accurate and reliable.

[0043] For example, to facilitate counting, the counting indicator 102 is initially positioned above the counting screw 101. As the number of uses increases, the counting indicator 102 moves downwards. The housing 1 can also have a scale near the counting window 61. The remaining dose can be more accurately determined based on the scale indicated by the counting indicator 102. If the remaining dose in the vial 112 is less than the amount needed for one dose, the patient can be promptly and accurately informed, reducing or even avoiding false dosing. Furthermore, an upper limit surface 611 and a lower limit surface 612 can be provided on the inner wall of the counting window 61, limiting the movement range of the counting indicator 102 between the upper limit surface 611 and the lower limit surface 612.

[0044] The aforementioned nozzle 5 is movable relative to the housing 1. The retainer 11 can move the medicine bottle 112 and the pump assembly 114 toward the nose port 31; wherein, the movement of the retainer 11 can trigger the spraying of medicine, and the movement of the pump assembly 114 can drive the nozzle 5 to move toward the nose port 31 before the medicine bottle 112 sprays. The movement of the retainer 11 or the nozzle 5 can drive the valve assembly 4-a / 4-b to the open position, and the movement of the retainer 11 can drive the counting screw 101 to rotate. That is to say, during the upward movement of the retainer 11, not only can spraying be achieved, but the nozzle 5, valve assembly 4-a / 4-b and counting screw 101 can also be linked. This linkage method can not only simplify the operation of the dual-power drug delivery device and improve the user experience, but also effectively ensure the coordination of multiple actions such as spraying, airflow assistance and counting.

[0045] During the upward movement of the retainer 11, the nozzle 5 also moves towards the nasal inlet 31 by approximately 0.5 to 3 mm. This allows the atomization point of the medication to penetrate deeper into the nasal cavity, delivering the medication more thoroughly. Simultaneously, it prevents the atomized medication from adhering to the inner wall of the nasal inlet 3, thus avoiding contamination and waste. After spraying is complete, the retainer 11 returns to its original position, and the nozzle 5 also moves downward to its original position.

[0046] See Figure 2 , Figure 3 and Figure 18 In some optional embodiments, the housing 1 further includes a limiting structure 69. When the nozzle 5 moves toward the nose socket 31 to the limiting structure 69, the limiting structure 69 prevents the nozzle 5 from moving further. The retainer 11 can continue to drive the pump assembly 114 to move relative to the nozzle 5 toward the nose socket 31, thereby opening the pump assembly 114 and triggering the pump assembly 114 to spray the drug. Before the nozzle 5 is limited by the limiting structure 69, the nozzle 5 can move synchronously with the movement of the retainer 11 and the pump assembly 114. The valve assemblies 4-a / 4-b can open the airflow passage 100 to its maximum extent when the nozzle 5 is limited by the limiting structure 69.

[0047] See Figure 1 The dual-powered drug delivery device is also equipped with a manual trigger element 8 such as a button. Pressing the button will move the retainer 11 toward the nose port 31.

[0048] The operation process of the dual-powered drug delivery device according to this application embodiment generally includes the following steps: 1. Insert the nose support 3 into the nostril, hold the mouth support 2 in your mouth, and blow air into the air outlet 22. At this time, the airflow channel 100 of the device is in a closed state, which will cause high pressure in the oral cavity and close the soft palate.

[0049] 2. Press the button to activate spray channel 513. Simultaneously, valve assembly 4-a / 4-b opens airflow channel 100, allowing airflow from mouthpiece channel 23 to enter airflow channel 100 and pass through nosepiece 31 into the nasal cavity, carrying the medication sprayed through spray channel 513 into the nasal vestibule. At the moment of spraying, the oral cavity is filled with high-pressure gas, causing the soft palate to close, preventing the medication from entering the airway or esophagus.

[0050] The following is combined Figures 2 to 20 The counting component 10, valve components 4-a / 4-b, and other structures (such as the drive structure of the medicine bottle 112, the mouth support 2, the protective cap 13, etc.) of the dual-power drug delivery device of this application will be described in further detail.

[0051] Counting component

[0052] See Figure 4 and Figure 5 The retaining member 11 is provided with a driving protrusion, which has a counting inclined surface. The counting screw 101 is provided with a transmission protrusion 1014, which has a transmission inclined surface. When the retaining member 11 moves, the counting inclined surface can move in contact with the transmission inclined surface, so that the counting screw 101 rotates around its axis. This linkage between the counting inclined surface and the transmission inclined surface eliminates the need for intermediate parts. The retaining member 11 and the counting screw 101 can directly contact each other to drive the screw to rotate and count, realizing the transmission of force. The structure is simple and also helps to save internal space of the housing 1 and reduce costs.

[0053] As previously described, the counting screw 101 is rotatably mounted on the housing 1, and the counting indicator 102 can move axially along the counting screw 101 as it rotates to count. When the manual trigger 8 is triggered, the holding member 11 moves upward, and the driving protrusion also moves upward. Since the screw is rotatable relative to the housing 1 but cannot move axially, the moving driving protrusion pushes the screw to rotate through the contact between the counting ramp and the transmission ramp, thus enabling the counting indicator 102 to count.

[0054] See Figure 4 and Figure 5 The driving protrusion is a boss formed by the protrusion of the main body side wall of the generally cylindrical retainer 11, and the transmission protrusion 1014 is a boss formed by the protrusion of the non-threaded section at the bottom of the generally cylindrical screw.

[0055] See Figure 18 and Figure 19The counting indicator 102 is mounted on the outside of the counting screw 101 by a cylindrical body. The outer wall of the counting screw 101 has an external thread 1011, and the inner wall of the cylindrical body of the counting indicator 102 has a single-turn internal thread. The housing 1 includes a left housing 6 and a right housing 7. Specifically, the housing body 14 generally includes the left housing 6 and the right housing 7. The left housing 6 and the right housing 7 are assembled to form a space for accommodating components such as the counting assembly 10, valve assembly 4-a / 4-b, pump assembly 114, nozzle 5, and medicine bottle 112. The nose support 3 is located on the left housing 6, and the button is located on the right housing 7. The bottom of the left housing 6 has a generally cylindrical support platform 62, and the upper part of the support platform 62 has a screw fixing position 63. The lower end of the counting screw 10 is inserted into the support platform 62, and the upper end is engaged with the screw fixing position 63. The counting indicator 102 is inserted from the upper end of the counting screw 101 and engages with the thread on the outer wall of the counting screw 101. The indicating boss 1021 is inserted into the counting window 61 of the left housing 6. The counting screw 101 and the counting indicator 102 are engaged by threads. When viewed from above the nose bearing 3, the counting screw 101 rotates clockwise and the counting indicator 102 moves downward.

[0056] See Figure 3 The indicator boss 1021 can be limited between the upper limit surface 611 and the lower limit surface 612 to prevent the counting indicator 102 from disengaging from the counting screw 101.

[0057] In some embodiments, the drive protrusion includes a first protrusion 1134 and a second protrusion 1135. The retainer 11 is in... Figure 4 In the initial state shown, the first protrusion 1134 is limited to the transmission protrusion 1014 to prevent the counting screw 101 from rotating; when the retainer 11 moves relative to the housing 1 toward the nose port 31, the first protrusion 1134 can be released from the transmission protrusion 1014, and the second protrusion 1135 can drive the counting screw 101 to rotate in the second preset direction through the transmission protrusion 1014.

[0058] Since the first protrusion 1134 is located within the transmission protrusion 1014, the counting screw 101 can remain in its original position and will not rotate due to the movement, shaking or falling of the dual-power drug delivery device, thus preventing inaccurate dosage.

[0059] The second preset direction can be either clockwise or counterclockwise.

[0060] "Initial state" can be understood as: the button is not pressed, the dual-power drug delivery device is not used, and the retainer 11 is stationary relative to the housing 1.

[0061] After pressing the button, the retainer 11 moves upward relative to the housing 1 toward the nose port 31. As the retainer 11 moves, the first protrusion 1134 disengages from the limiting position on the transmission protrusion 1014, making the counting screw 101 rotatable. When the second protrusion 1135 moves to abut against the transmission protrusion 1014, the counting inclined surface of the second protrusion 1135 moves in contact with the transmission inclined surface, pushing the counting screw 101 to rotate and start counting. At this time, the device is also in spray mode.

[0062] In some alternative embodiments, when the retainer 11 moves away from the nose port 31 relative to the housing 1, the first protrusion 1134 can drive the counting screw 101 to rotate in a second preset direction via the transmission protrusion 1014 before the retainer 11 returns to its initial state. That is, during the downward resetting process of the retainer 11, the transmission protrusion 1014 can still drive the counting screw 101 to rotate, and the counting indicator 102 will still count. Thus, the dose change caused by a single spray is achieved through two stages of counting: one stage is the counting during the upward movement of the retainer 11 in the spray state, and the other stage is the counting during the downward resetting process of the retainer 11. In these two stages, the sum of the axial changes of the counting indicator 102 along the counting screw 101 matches the dose of a single spray. This counting method fully utilizes the driving force of the retainer 11 during its downward movement to drive the counting screw 101 to rotate, shortening the unidirectional stroke of the retainer 11 (especially the upward movement stroke), effectively reducing the difficulty for the user to apply external force to drive the retainer 11 upward by pressing a button. Moreover, this method also makes the device structure more compact.

[0063] In some alternative embodiments, when the retainer 11 moves relative to the housing 1 toward the nose socket 31, see [reference needed]. Figure 5 The second protrusion 1135 can continue to move to the position limited by the transmission protrusion 1014 after the counting screw 101 has rotated a preset number of times in the second preset direction. Based on the above, as the retaining member 11 continues to move upward (while the button is still pressed), the counting ramp of the second protrusion 1135 gradually disengages from the transmission ramp of the transmission protrusion 1014. The second protrusion 1135 can no longer drive the counting screw 101 to rotate, but it will be in a position that limits the rotation of the counting screw 101. At this time, the button is still pressed, the retaining member 11 rises to its highest position, and the retaining member 11 is stationary relative to the housing 1. The limiting effect of the second protrusion 1135 ensures that the counting screw 101 remains in its original position and will not rotate due to movement, shaking, or dropping of the dual-power drug delivery device, thus ensuring the accuracy of the dosage.

[0064] In some alternative embodiments, the counting ramp includes a second counting ramp 1133 located on the second protrusion 1135, and the counting screw 101 includes a plurality of drive protrusions 1014 distributed circumferentially thereon, with the drive ramp including a second ramp 1013 located on each drive portion; when the retainer 11 is in the initial state, see [reference needed]. Figure 4 The first protrusion 1134 is at least partially located within the gap between two adjacent transmission protrusions 1014. Since the retainer 11 cannot rotate relative to the housing 1, the retainer 11 can restrict the rotation of the counting screw 101 relative to the housing 1 through the first protrusion 1134. When the button is pressed, as the retainer 11 moves relative to the housing 1 toward the nose socket 31, the first protrusion 1134 can disengage from the gap to release the restriction, and the second counting ramp 1133 can move in contact with the second ramp 1013 to make the counting screw 101 rotate in the second preset direction.

[0065] In some alternative embodiments, see Figure 4 and Figure 5 The counting ramp also includes a first counting ramp 1132 located on the first protrusion 1134, and the transmission ramp includes a first ramp 1012 located on each transmission protrusion. When the retainer 11 moves away from the nose bearing 31 relative to the housing 1, the first counting ramp 1132 can move in contact with the first ramp 1012 to make the counting screw 101 rotate in a second preset direction. The cooperation between the first counting ramp 1132 and the first ramp 1012 is used to drive the screw to rotate during the descent of the retainer 11. In conjunction with the foregoing description, when the retainer 11 moves relative to the housing 1, the first protrusion 1134 or the second protrusion 1135 can make the counting screw 101 rotate. Specifically: during the descent of the retainer 11, the counting screw 101 is driven by the second protrusion 1135; during the descent and reset of the retainer 11, the counting screw 101 is driven by the first protrusion 1134. When the retainer 11 is stationary relative to the housing 1, the first protrusion 1134 or the second protrusion 1135 can restrict the rotation of the counting screw 101. Therefore, the first protrusion 1134 and the second protrusion 1135 can achieve both driving and limiting functions at different stages, with one component having multiple functions, further reducing the number of parts in the device, improving the device's compactness, and reducing costs.

[0066] Figure 4 and Figure 5 The diagrams show the relative positional relationship between the retainer 11 and the counting screw 101 in two static states. Figure 4 The structure of the counting component 10 in the initial state of the retainer 11 is shown. Figure 5 The structure of the counting assembly 10 is shown when the retainer 11 is in its highest position (i.e., when the spray has ended). See also Figure 5When the retainer 11 moves relative to the housing 1 toward the nose port 31, the second protrusion 1135 can continue to move into the interval after the second counting slope 1133 disengages from the second slope 1013.

[0067] During the resetting process of the retainer 11 (i.e., when the retainer 11 moves away from the nose bearing 31 relative to the housing 1), the first protrusion 1134 can continue to move into the interval after the first counting ramp 1132 disengages from the first ramp 1012. At this time, the retainer 11 resets to its original position. Figure 4 The initial state is shown.

[0068] For example, see Figure 4 and Figure 5 In some alternative embodiments, the first protrusion 1134 is located above the second protrusion 1135.

[0069] In some alternative embodiments, the first protrusion 1134 and the second protrusion 1135 are spaced apart. As can be seen from the foregoing description, the distance between the first protrusion 1134 and the second protrusion 1135 is related to the upper and lower limit positions of the retainer 11's axial movement, that is, to the entire stroke of the retainer 11's axial movement.

[0070] In some alternative embodiments, the first inclined surface 1012 and the second inclined surface 1013 are located at the upper and lower ends of the transmission protrusion 1014, respectively.

[0071] The counting process is described in more detail below: See Figure 4 Before the button is pressed, the first protrusion 1134 is located between the two transmission protrusions 1014. At this time, the first holding surface 1136 of the first protrusion 1134 is close to the transmission protrusion 1014, so that the counting screw 101 remains in the original position.

[0072] When the button is pressed, the retaining member 11 (specifically, the medicine bottle base 113, which will be further described below) moves upward. After the first protrusion 1134 disengages from the transmission protrusion 1014, the counting screw 101 can rotate. The second counting inclined surface 1133 engages with the second inclined surface 1013. The second counting inclined surface 1133 continues to move upward, pushing the transmission protrusion 1014 to rotate clockwise until the second retaining surface 1137 of the second protrusion 1135 engages with the transmission protrusion 1014. When the retaining member 11 reaches the second position (which can be understood as the highest position that the retaining member 11 can reach), the second protrusion 1135 is located between the two transmission protrusions 1014, and the counting screw 101 cannot rotate.

[0073] After the button is released, the retainer 11 moves downward, causing the medicine bottle 112 and pump assembly 114 to reset. The second retaining surface 1137 of the second protrusion 1135 gradually disengages from the transmission protrusion 1014, allowing the counting screw 101 to rotate. The first counting surface engages with the first inclined surface 1012, pushing the transmission protrusion 1014 to rotate clockwise until the first protrusion 1134 is positioned between the two transmission protrusions 1014. The first retaining surface 1136 of the first protrusion 1134 engages with the transmission protrusion 1014, restricting the rotation of the counting screw 101 and ensuring the accuracy of the dosage indicator.

[0074] Valve assembly 4-a / 4-b Figure 6 and Figure 10 The implementation methods of two valve assemblies 4-a and 4-b are shown respectively.

[0075] See Figure 6 and Figure 10 In some optional embodiments, the valve assembly includes a valve core 41-a / 41-b, a valve switch 42-a / 42-b, and a force steering structure; the force steering structure is used to convert the axial movement of the nozzle 5 or the retainer 11 into movement applied to the valve switch along a first preset direction, and the movement of the valve switch 42-a / 42-b along the first preset direction can open or close the airflow passage 100; wherein, the first preset direction is not parallel to the axial direction.

[0076] In the embodiments of this application, see Figure 2 In the embodiment of this application, the housing 1, retainer 11, medicine bottle 112, nozzle 5 and pump assembly 114 are all arranged approximately coaxially. Therefore, the "axial direction" mentioned in this application embodiment also refers to the axial direction of these components, and the movement of retainer 11 is also approximately along this axial direction.

[0077] The movement of retainer 11, whether rising or falling, refers to movement approximately along its axial direction.

[0078] The counting screw 101 is located to the side of the retainer 11, and the axis of the counting screw 101 is approximately parallel to the axis of the retainer 11.

[0079] In this embodiment, valve assemblies 4-a / 4-b are generally positioned at the connection between the inlet 2 and the housing body, and are located to the side of the axis of the dual-power drug delivery device. Generally, the inner diameter of the inlet channel 23 is small, and valve assemblies 4-a / 4-b can more easily achieve the opening or closing of the airflow channel 100 by opening or closing the outlet of the inlet channel 23, resulting in better reliability of the opening and closing control of the airflow channel 100. Moreover, the placement of valve assemblies 4-a / 4-b here will not significantly interfere with the spraying process (the spraying devices involved in the spraying process are basically moving in the axial direction), resulting in a more scientific spatial layout and effectively improving the overall reliability of the device.

[0080] See Figure 3 and Figure 18 The main housing also includes a connecting boss 65 that protrudes horizontally outward from the inner cavity. The connecting boss 65 has a hollow space 651 communicating with the inner cavity. The valve cores 41-a / 41-b are at least partially located in the hollow space 651, and the bearing 2 is connected to the connecting boss 65.

[0081] By utilizing the force-directing structure, the placement of the connecting boss 65 can be made more flexible, thereby reducing the manufacturing difficulty of the housing 1. For example, when manufacturing the housing 1 using methods such as injection molding, it is roughly as follows: Figure 3 The horizontally positioned connecting boss 65 shown makes demolding easier.

[0082] The connecting boss 65 provides some protection for the valve cores 41-a / 41-b, especially those with elastic diaphragms 412-a / 412-b (mentioned below), which require even more protection. The connecting boss 65 also extends the inner cavity 141 of the housing body 14. Figure 2 The space of the connecting boss 65 is fully utilized to install the valve core 41-a / 41-b, improving space utilization. Furthermore, the connecting boss 65 facilitates the installation of the bearing 2. When the bearing 2 is deformable (mentioned below), the connecting boss 65 allows the deformed portion of the bearing 2 to be moved away from the housing body 14 (i.e., away from the root of the bearing 2), transferring more of the deformed portion to the bent part of the bearing 2. This extends the service life of the bearing 2, and improves the sealing at the connection between the bearing 2 and the connecting boss 65, reducing the likelihood of air leakage.

[0083] It is understandable that the sealing of parts such as the mouthpiece 2 and the airflow channel 100 involves the airflow process. The better the sealing of these parts, the better it is to ensure that the oral cavity does not leak air during the patient's blowing process. The oral cavity is more likely to maintain high pressure, thereby ensuring that the soft palate inside the oral cavity is closed and that the liquid medicine does not enter the airway or esophagus during spraying.

[0084] Based on this valve assembly 4-a / 4-b layout, the movement of the valve switch and the movement of the spray assembly are not parallel. In the embodiment illustrated in this application, the first preset direction is substantially perpendicular to the axial direction, that is, the first preset direction is substantially parallel to the horizontal direction.

[0085] By utilizing the force steering structure to convert the axial movement of the retainer 11 into the first preset direction movement of the valve switch, the linkage between the retainer 11 and the valve assembly 4-a / 4-b is realized. This facilitates the coordination of the two steps of spraying and opening the airflow channel 100, ensuring that the airflow channel 100 can be opened during spraying, and also helps to improve the utilization rate of the internal space of the housing 1.

[0086] In some alternative embodiments, the housing 1 is provided with a track 64 extending along a first preset direction, and the valve switches 42-a / 42-b move along the track 64. When the retainer 11 or the nozzle 5 moves toward the nose socket 31, the retainer 11 or the nozzle 5 can drive the valve switch 42-a to move toward the valve core 41-a / 41-b in the track 64 along the first preset direction via the valve connecting rod 43; when the retainer 11 or the nozzle 5 moves away from the nose socket 31 to reset, the retainer 11 or the nozzle 5 drives the valve switch 42-a to move away from the valve core 41-a / 41-b in the track 64 along the first preset direction via the valve connecting rod 43.

[0087] The track 64 can limit the axial displacement of the valve switch 42-a, ensuring that the valve switches 42-a / 42-b move along the first preset direction, thereby allowing the valve switches 42-a / 42-b to switch back and forth between the two positions of opening the valve core 41-a and not opening the valve core 41-a.

[0088] The following are combined with Figures 6 to 8 The first type of valve assembly shown, and Figures 10 to 13 The second type of valve assembly shown will be described.

[0089] First type of valve assembly Combination Figure 6 and Figure 7 The valve core 41-a includes an elastic membrane 412-a with a slit 411-a. The movement of the valve switch 42-a toward the valve core 41-a allows the valve switch 42-a to cover the slit 411-a. The elastic membrane 412-a can tightly adhere to the valve switch 42-a using its own elasticity to close the airflow channel 100. The movement of the valve switch 42-a away from the valve core 41-a allows the valve switch 42-a to separate from the elastic membrane 412-a. The airflow from the air outlet 22 can deform the elastic membrane 412-a to increase the slit 411-a and open the airflow channel 100.

[0090] The elasticity of the elastic membrane 412-a can be used to improve the tightness of the fit between the elastic membrane 412-a and the valve switch 42-a, which in turn helps to increase the closing effect of the valve assembly on the airflow channel 100.

[0091] The elastic closed airflow channel 100 using the elastic membrane 412-a offers higher reliability and lower cost.

[0092] exist Figure 7 In the implementation shown, the elastic membrane 412-a includes four valves, and two intersecting gaps 411-a are formed between the four valves. The material of the valves is preferably silicone. When no external force is applied, the four valves adhere to each other, and the gaps 411-a basically disappear. Figure 7For illustrative purposes only, the number of valves in the elastic membrane 412-a may also be 5 or more, and the number of slits 411-a may also be 3 or more. The number of valves and slits 411-a are not intended to limit this application.

[0093] See Figure 6 In some alternative embodiments, the force steering structure includes a valve rod 43, one end of which is pivotally connected to the nozzle 5, and the other end of which is pivotally connected to the valve switch 42-a. In other implementations, one end of the valve rod 43 may also be pivotally connected to the retainer 11. The following description uses the example of the valve rod 43 being pivotally connected to the nozzle 5.

[0094] See Figure 6 The valve connecting rod 43 is directly connected to the nozzle 5 (or retainer 11), without the need for intermediate parts, which reduces the number of parts in the device and makes the linkage simple and convenient. Moreover, by using the upward or downward movement of the retainer 11, the valve switch 42-a is driven to switch back and forth between the open valve core 41-a and the closed valve core 41-a positions, without the need for elastic parts or other components, resulting in a simple and compact structure.

[0095] See Figure 6 The valve connecting rod 43 is bent at a certain angle. By adjusting the bending angle of the valve connecting rod 43 and the ratio of the lengths of the two ends of the bend (such as the ratio of a to b), the displacement transmission ratio between the valve switch 42-a and the nozzle 5 can be adjusted. For example, if the nozzle moves up 1mm, the valve switch moves to the left 1mm, and the displacement transmission ratio is 1:1. Alternatively, if the nozzle moves 1mm, the valve switch moves to the left 2mm, and the displacement transmission ratio is 1:2.

[0096] Valve connecting rod 43 in Figure 6 The structure is roughly inverted V-shaped. This structure not only improves the utilization of the internal space of the housing 1, but also allows for smoother movement of the valve switch 42-a.

[0097] In the first type of valve assembly, the reset of valve switch 42-a does not require the aid of a spring element. Figures 6 to 9 In the implementation shown, valve switch 42-a is provided with valve boss 421-a corresponding to gap 411-a. Figure 8The valve rod 43 has two pivot bosses 431; the nozzle 5 includes a nozzle body 51, which has a second pivot and a protruding shoulder 512. The pivot bosses 431 at both ends of the valve rod 43 respectively engage with the first pivot of the valve core 41-a and the second pivot of the nozzle 5. Both the first pivot 422 and the second pivot are groove structures. The valve core 41-a is installed in the track of the left outer casing, restricting its axial displacement relative to the nozzle body. When the nozzle body moves upward, the valve plug moves along the axis of the valve core 41-a through the linkage of the valve rod 43.

[0098] When the dual-power drug delivery device is in its initial state, the valve switch 42-a is tightly fitted with the valve core 41-a, the valve boss 421-a is tightly fitted with the gap 411-a, and at the same time the valve boss 421-a abuts against the valve, the valve assembly is in a closed state, and airflow cannot pass through.

[0099] When using, first hold the mouthpiece 2 in your mouth and blow air into your mouth. At this time, the valve assembly is not open, and the gas is stored in the mouthpiece channel 23. After pressing the button, the button moves the medicine bottle 112 upward. The nozzle 5 drives the valve switch 42-a through the valve connecting rod 43, disengaging it from the valve core 41-a. High-pressure airflow is present in the mouthpiece 2. The valve loses the support of the valve boss 421-a and begins to deform towards the low-pressure side, which increases the gap 411-a. The airflow can then pass through the valve core 41-a, enter the airflow channel 100, and then pass through the nosepiece 3 to enter the nasal cavity.

[0100] The second type of valve assembly See Figure 10 and Figure 11 The valve core 41-b includes a slit 411-b ( Figure 15 The elastic membrane 412-b is capable of closing the elastic slit 411-b; the valve switch 42-b is capable of opening the elastic membrane 412-b so that the valve assembly can conduct air inlet 22 and nose port 31 through slit 411-b.

[0101] For the second type of valve assembly, the valve switch 42-b is used to open the airflow passage 100, but not to close it. The closure of the airflow passage 100 relies on the elasticity of the elastic diaphragm 412-b in the valve core 41-b. Compared with valve assemblies that rely on the cooperation of the valve switch and the valve core to close the airflow passage, the valve assembly of this embodiment has a more reliable closing effect and is more conducive to ensuring the cleanliness of the inside of the housing 1. Since the requirements for the fit between the valve core 41-b and the valve switch 42-b are reduced, the structure is simpler, easier to assemble, and the valve assembly with the elastic diaphragm 412-b is less expensive.

[0102] See Figure 11The elastic membrane 412-b includes at least two valves, preferably made of silicone. When no external force is applied, the valves will automatically close under their own elasticity, forming a tight seal. At this time, airflow can only flow in from the inlet end 413 and cannot flow in from the outlet end 414 to the inlet end 413, thus forming a one-way valve.

[0103] Because the second valve assembly is a one-way valve, it will not leak air regardless of the input pressure at the air outlet 414. In other words, even if the pressure input by the patient towards the air inlet 22 is high, as long as the valve switch 42-b does not open the elastic diaphragm 412-b, no airflow will enter the airflow channel. Furthermore, the higher the air pressure, the better the sealing performance.

[0104] See Figure 12 and Figure 13 The force steering structure includes a first braking ramp 1112 disposed on the retainer 11 and a second braking ramp 424 disposed on the valve switch 42-b. The first braking ramp 1112 abuts against the second braking ramp 424. When the retainer 11 or the nozzle 5 moves toward the nose port 31, the first braking ramp 1112 can drive the second braking ramp 424 to move away from the valve core 41-b to the position where the valve core 41-b is opened. The elastic membrane 412-b is stretched open by the valve switch 42-b, and the gap 411-b becomes larger. A gas flow channel can also be provided inside the valve switch 42-b, and the gap 411-b is connected to the airflow channel 100 through the gas flow channel.

[0105] Figure 9 It is a vial base 113 adapted to the first type of valve assembly. (Comparison) Figure 9 and Figure 13 The medicine bottle base 113 adapted to the first type of valve assembly does not have a first braking ramp 1112.

[0106] In addition, in some other implementations, the first braking slope 1112 can also be provided on the nozzle 5.

[0107] By utilizing the first braking inclined surface 1112 and the second braking inclined surface 424 to abut and move relative to each other, the axial movement of the retaining member 11 or the nozzle 5 is transformed into the horizontal movement of the valve switch 42-b, resulting in a simple and compact structure.

[0108] In some alternative embodiments, the valve assembly also includes an elastic element capable of resetting the valve switch 42-b to the position where the valve core 41-b is closed (this position may also be referred to as the initial position).

[0109] The elastic element can be Figure 10 The spring shown can also be a spring sheet, an elastic rubber component, etc.

[0110] See Figure 16 and Figure 17The retainer 11 includes two parts: a bottle cap 111 and a bottle base 113. The bottle 112 and the retainer 11 together form a bottle assembly. See also Figure 2 A sealing ring 9 is also provided at the connection between the medicine bottle cap 111 and the shell 1.

[0111] When using the device, the patient first holds the mouthpiece 2 in their mouth and blows air forcefully. At this time, the outer side of the valve core 41-b is subjected to air pressure, making the closure tighter and preventing air leakage. Due to the high pressure in the oral cavity, the soft palate inside the patient's mouth will close. After inserting the nose support 3 into the nasal cavity, the button is pressed. At this time, the button will cause the medicine bottle cap 111 to move upward. The first braking slope 1112 on the medicine bottle cap 111 fits against the second braking slope 424 on the valve switch 42-b. Through the cooperation of the two slopes, the vertical upward movement of the medicine bottle cap 111 is converted into the horizontal movement of the valve switch 42-b. The valve boss 421-b of the valve switch 42-b is inserted into the inlet end 413 of the valve core 41-b, separating the two valves. At this time, the valve core 41-b is opened, and the air blown out of the mouthpiece 2 can flow from the outlet end 414 to the inlet end 413, and enter the nasal cavity through the nose support 3. This airflow helps to atomize the medication and carries the droplets deeper into the nasal cavity. Because the soft palate is closed, the medication will eventually be deposited in the nasal vestibule and will not enter the airway or esophagus, thus enhancing the therapeutic effect.

[0112] After the button is released, the retainer 11 can move downwards to reset under the weight of the medicine bottle 112 and the retainer 11. During the reset process of the retainer 11, the elastic element uses its elastic force to reset the valve switch 42-b. The elastic element can also maintain the initial position of the valve switch 42-b when the retainer 11 is stationary relative to the housing 1, and the airflow passage 100 is not opened.

[0113] Drive structure of medicine bottle The manual trigger 8 is used to trigger the retainer 11 to move toward the nose socket 31. See also Figures 1 to 3 The manual trigger 8 is installed on the housing 1 and includes multiple finger placement parts 81. The housing body has a thumb position 68 on the opposite side of the manual trigger 8, so that the other four or three fingers can press the manual trigger 8. With the five fingers working together, the structural design is more ergonomic and the pressing is less strenuous.

[0114] The manual trigger 8 and the retaining member 11 are linked by a wedge mechanism. The wedge mechanism can convert the force of the manual trigger 8 moving in the first preset direction into the force that drives the retaining member 11 to move in its axial direction.

[0115] See Figure 16 and Figure 17In some alternative embodiments, the wedge mechanism includes a first triggering ramp 83 located on the manual trigger 8 and a second triggering ramp 1151 located on the retainer 11. Under the action of an external force in a first preset direction, the manual trigger 8 can slide by the first triggering ramp 83 against the second triggering ramp 1151, so that the retainer 11 moves toward the nose socket 31 along its axial direction.

[0116] The vial 112 and the retainer 11 together form a vial assembly. Figure 16 This is a schematic diagram of the structure of the medicine bottle assembly before the medicine bottle 112 is activated, that is, before the button is pressed, which can also be understood as the device being in its initial state. Figure 17 This is a schematic diagram of the structure of the medicine bottle assembly after the button is pressed.

[0117] The structure of the first trigger ramp 83 and the second trigger ramp 1151 being attached and sliding relative to each other can convert the axial movement of the retaining member 11 into the lateral horizontal movement of the button, that is, the movement direction of the manual trigger member 8 is perpendicular to the axis of the nose bearing 31. This linkage method of changing the force direction through direct hard contact has a simple structure, fewer parts, and helps to reduce costs.

[0118] Moreover, compared with rotation and other movement methods, the horizontal movement of the button towards the bearing 2 in this embodiment of the application is more in line with the patient's usage habits and can improve the user experience.

[0119] In the initial state, due to the weight of the vial assembly itself, the first triggering ramp 83 and the second triggering ramp 1151 can fit tightly together. The vial cap 111 and the vial base 113 are each provided with at least one protrusion 151, and each protrusion 151 is provided with a second triggering ramp 1151. See also... Figure 21 The manual trigger 8 is also equipped with a hook 82 and multiple first trigger ramps 83. The hook 82 is engaged with the inner wall of the right shell 7 to prevent the manual trigger 8 from dislodging from the right shell 7. In use, the thumb presses the thumb position 68 of the left shell 6, and the other four or three fingers press the multiple finger placement parts 81 on the manual trigger 8, causing the manual trigger 8 to move horizontally inward. The medicine bottle 112 and the retainer 11 are constrained by the left shell 6 and the right shell 7 and cannot move horizontally, but can only move vertically. Under the action of the first trigger ramp 83 and the corresponding second trigger ramp 1151, the horizontal movement of the button is converted into the up and down movement of the medicine bottle assembly composed of the medicine bottle 112 and the retainer 11.

[0120] See Figure 22In another implementation, the wedge mechanism includes a first trigger ramp 83 on the manual trigger 18 and a curved surface 1611 on the retainer 11, with the first trigger ramp 83 in line contact with the curved surface 1611. Here, the curved surface 1611 can be the elliptical circumference of a generally elliptical cylindrical boss 161 protruding from the sidewall of the retainer 11. Relative Figure 16 and Figure 17 Regarding the surface contact method where the first triggering inclined surface 83 and the second triggering inclined surface 1151 are in contact... Figure 22 This line contact method requires less effort and makes it easier to push the retaining component 11 upward.

[0121] In some embodiments not illustrated in this application, the curved surface may also be disposed on the manual trigger 18, and the first trigger ramp that fits against the curved surface may be disposed on the retainer 11.

[0122] The nozzle 5 moves upward synchronously with the medicine bottle assembly. After about 0.5 to 3 mm, the protruding shoulder 512 on the nozzle 5 comes into contact with the nozzle limiting structure 69 inside the housing 1 (i.e., one implementation of the aforementioned limiting structure 69). The nozzle 5 can no longer move upward, while the medicine bottle assembly continues to move upward, squeezing the pump assembly 114 and causing the buffered medicine to be squeezed. Since there is a one-way valve at the bottom of the pump assembly 114, the medicine can only flow upward, through the nozzle assembly, and be sprayed out from the swirling chamber (i.e., the spray channel 513) on the nozzle 5 to form atomized droplets.

[0123] In addition, the right shell 7 is provided with an external dustproof platform 74 and an internal dustproof platform 75. Before the button is pressed, the external dustproof platform 74 blocks dust from entering the device; after the button is pressed, the internal dustproof platform 75 blocks dust from entering the device from the bottom.

[0124] Figure 9 The bottle cap 111 shown is applied to a bottle with Figure 6 The valve assembly shown is a dual-powered drug delivery device. Figure 13 The bottle cap 111 shown is applied to a bottle with Figure 10 The valve assembly shown is a dual-powered drug delivery device. A comparison of the two reveals that... Figure 13 The cap 111 of the traditional Chinese medicine bottle is provided with the aforementioned first braking inclined surface 1112, and Figure 9 The cap of the Chinese medicine bottle 111 does not have a first braking slope 1112. Figure 12 The gap 423 in the middle is used for avoidance. Figure 10 Rib position of nozzle 5.

[0125] Regarding pump assembly 114: Pump assembly 114 may be any existing pump assembly 114, and its specific structure is not intended to limit this application. For ease of understanding, pump assembly 114 is briefly described below. Pump assembly 114 includes a suction tube 1142, a metering valve 1141, and a check valve. Under the action of the check valve, the suction tube 1142 can only draw the liquid medicine in the medicine bottle 112 into the metering valve 1141, and will not flow back from the metering valve 1141 into the medicine bottle 112. When pump assembly 114 moves upward relative to nozzle 5, the spring of metering valve 1141 is compressed, and the liquid medicine in metering valve 1141 is compressed into the vortex chamber of nozzle 5. The inner wall of the vortex chamber is a vortex groove. According to the principle of vortex atomization, the liquid medicine moves radially outward under the action of centrifugal force, and extends into a liquid film on the rotating surface of the vortex groove. Centrifugal force overcomes the surface tension and viscosity of the liquid, causing the liquid film to continuously thin, and detach from the surface at the rotating edge to form a filamentous or ribbon-like structure. High-speed airflow or ambient gas interacts with the liquid filaments and liquid bands, further breaking them down into micron-sized droplets through gas-liquid shear forces. When the button is released, the spring resets the metering valve 1141, and simultaneously, the suction tube 1142 draws the required liquid for the next spray from the medicine bottle 112. This cycle repeats continuously.

[0126] oral tradition The mouthpiece 2 is at least partially deformable. Since the relative positions between the mouth and nose of different patients are different, the deformability of the mouthpiece 2 can increase the degree of freedom between the mouthpiece 2 and the nosepiece 3, so that the dual-power drug delivery device can adapt to different patients.

[0127] See Figure 1 The dual-powered drug delivery device also includes an oral support core 21 located at least within the oral support channel 23. The oral support core 21 supports the oral support channel 23, and the oral support 2 can adjust the relative position between the blowing port 22 and the nose port 31 by deformation. The oral support core 21 supports the oral support channel 23, reducing the impact of the oral support channel 23 being flattened and affecting airflow. Moreover, the oral support core 21 supports the oral support channel 23, allowing the outer wall of the oral support 2 to better fit the lips, reducing air leakage during blowing, improving the seal between the oral support 2 and the lips, and facilitating blowing.

[0128] In some embodiments, the mouth support core 21 is at least partially located at the air outlet 22 and extends in the direction of airflow. The mouth support core 21 is positioned close to the air outlet 22, which reduces the possibility of the mouth support 2 being flattened and ensures its support for the mouth support channel 23, allowing for smooth flow in the mouth support channel 23.

[0129] Generally, the length of the bearing core 21 is less than the length of the bearing channel 23. This reduces the impact of the bearing core 21 on the deformability of the bearing 2.

[0130] See Figure 2The side wall of the mouth-bearing channel 23 is provided with an installation groove, which is adjacent to the air blowing port 22, and the mouth-bearing core 21 can be installed in the installation groove.

[0131] See Figure 1 The inlet support core 21 includes a core cylinder 211 and a support rib 212. The core cylinder 211 is connected to the side wall of the inlet support channel 23. The two ends of the support rib 212 are connected to the side wall of the core cylinder, and are not parallel to the axis of the core cylinder. The support rib 212 is used to strengthen the support force on the inner wall of the core cylinder 211, ensuring strength while allowing air to pass through.

[0132] For example, the hardness of the bearing core 21 is greater than that of the bearing 2. For instance, the bearing 2 is made of soft plastic, while the bearing core 21 is made of hard plastic. This ensures the support effect of the bearing core 21.

[0133] In some implementations, the mouthpiece 2 is made of a flexible or elastic material, allowing the entire mouthpiece 2 to deform. Elastic materials include, but are not limited to, soft plastic or silicone. Soft plastic can adapt to various situations, allowing the patient to adjust it themselves, ensuring sufficient adjustment range between the mouthpiece 2 and the nasal support 3.

[0134] See Figure 3 The shell body has a connecting boss 65, and the mouth support 2 is set outside the connecting boss 65.

[0135] The connection between the bearing channel 23 and the connecting boss 65 of the left shell 6 can be achieved using processes such as adhesive bonding, ultrasonic welding, insert injection molding, and overmolding. The connection between the bearing 2 and the bearing core 21 can also use the same process to ensure a tight and sealed connection.

[0136] Protective cover 13 See Figure 20 The dual-power drug delivery device also includes a protective cover 13 and a connector. The connector connects the protective cover 13 and the shell body respectively, and allows the protective cover 13 to rotate relative to the shell body. During rotation, the protective cover 13 can open the nose port 31 and the air inlet 22.

[0137] By rotating the protective cover 13 in different directions, the nose port 31 and the air inlet 22 can be closed or opened simultaneously. There is no need to provide separate covers for the nose port 31 or the air inlet 22, making it convenient to use.

[0138] When the device is not in use, the nose port 31 and the air outlet 22 can be closed by using the protective cover 13 to reduce the entry of foreign objects such as dust into the device and reduce or even avoid the risk of the moving parts inside the device being stuck by foreign objects.

[0139] The protective cover 13 is also movable vertically relative to the shell body, so that the protective cover 13 avoids the nose support 3 on the top of the shell 1 before opening or closing the nose support 31 and the air inlet 22, wherein the nose support 3 is provided with the nose support 31.Figure 2 To conform to the human body structure and facilitate use, the top of the nose port 31 is higher than the top of the air inlet 22. Before the protective cover 13 is rotated, it should be moved up or down to avoid the nose port 31, making the operation smoother.

[0140] The operating logic of the protective cover 13 generally includes: 1. First, lift the protective cover 13 upwards until the protective cover 13 is disengaged from the nose support 3 and can be rotated without being blocked by the nose support 3. Then rotate the protective cover 13 to complete the opening action. 2. After spraying, when closing the dust cover, first rotate the protective cover 13 so that it is above the nose support 3, and then press the protective cover 13 down to make it engage with the nose support 3 and the mouth support 2.

[0141] The various embodiments or implementation methods described in this specification are presented in a progressive manner. Each embodiment focuses on the differences from other embodiments, and the same or similar parts between the embodiments can be referred to each other.

[0142] In the description of this specification, references to "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with an embodiment or example is included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0143] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. A dual-powered drug delivery device, characterized in that, The dual-powered drug delivery device includes: The housing includes a nose inlet, an air outlet, and an airflow channel connecting the air outlet and the nose inlet; Valve assembly, at least for opening the airflow passage; The nozzle has a spray channel leading to the nose port and is movable relative to the housing; A retainer is provided for moving a medicine bottle containing medicine relative to the housing. The medicine bottle is equipped with a pump assembly. The pump assembly can draw medicine from the medicine bottle and spray the medicine out of the nose cup through the spray channel. A counting assembly includes a counting screw and a counting indicator threaded to the counting screw, the counting screw being rotatably mounted on the housing; The retainer can move the medicine bottle and the pump assembly toward the nose socket; wherein, the movement of the retainer can trigger the medicine to be sprayed, the movement of the pump assembly can move the nozzle toward the nose socket before the medicine bottle is sprayed, the movement of the retainer or the nozzle can move the valve assembly to the open position, and the movement of the retainer can rotate the counting screw.

2. The dual-powered drug delivery device according to claim 1, characterized in that, The housing also includes a limiting structure. When the nozzle moves toward the nose socket to the limiting structure, the limiting structure prevents the nozzle from moving further. The retainer can continue to drive the pump assembly to move relative to the nozzle toward the nose socket to trigger the pump assembly to spray the medicine.

3. The dual-powered drug delivery device according to claim 1, characterized in that, The valve assembly includes a valve core, a valve switch, and a force steering structure; The force steering structure is used to convert the axial movement of the nozzle or the retainer into a movement applied to the valve switch along a first preset direction, the movement of the valve switch along the first preset direction being able to open or close the airflow channel; wherein, the first preset direction is not parallel to the axial direction.

4. The dual-power drug delivery device according to claim 3, characterized in that, The valve core includes an elastic membrane with a slit. The movement of the valve switch allows the valve switch to cover the slit, and the elastic membrane can use its elasticity to tightly fit the valve switch to close the airflow channel. The movement of the valve switch can also separate the valve switch from the elastic membrane, and the airflow from the air outlet can deform the elastic membrane to increase the gap and open the airflow channel.

5. The dual-powered drug delivery device according to claim 3 or 4, characterized in that, The force steering structure includes a valve link, one end of which is pivotally connected to the nozzle or the retainer, and the other end of which is pivotally connected to the valve switch.

6. The dual-powered drug delivery device according to claim 3, characterized in that, The housing is provided with a track extending along a first preset direction, and the valve switch moves along the track.

7. The dual-powered drug delivery device according to claim 3, characterized in that, The valve core includes an elastic membrane with a slit, which can elastically close the slit. The valve switch can expand the elastic membrane so that the valve assembly can conduct air through the gap to the air inlet and the nose port.

8. The dual-powered drug delivery device according to claim 7, characterized in that, The force steering structure includes a first braking ramp disposed on the retainer or the nozzle, and a second braking ramp disposed on the valve switch; When the retainer or the nozzle moves toward the nose socket, the first braking slope can move in contact with the second braking slope, so that the valve switch moves from the initial position to the position where the elastic membrane is opened.

9. The dual-powered drug delivery device according to claim 8, characterized in that, The valve assembly also includes an elastic element that can drive the valve switch to reset to its initial position.

10. The dual-powered drug delivery device according to claim 1, characterized in that, The retainer is provided with a driving protrusion, which has a counting inclined surface. The counting screw is provided with a transmission protrusion, which has a transmission inclined surface. When the retainer moves, the counting inclined surface can move in contact with the transmission inclined surface so that the counting screw can rotate around its axis.

11. The dual-powered drug delivery device according to claim 10, characterized in that, The counting screw is provided with a plurality of transmission protrusions along its circumference, and the driving protrusions include a first protrusion and a second protrusion. When the retainer is stationary relative to the housing, the first protrusion is located within the space between two adjacent transmission protrusions to impede the rotation of the counting screw; when the retainer moves relative to the housing, the first protrusion can move outside the space, and the counting ramp of the second protrusion can move in contact with the transmission ramp to allow the counting screw to rotate; or, When the retainer is stationary relative to the housing, the second protrusion is located in the space between two adjacent transmission protrusions to prevent the counting screw from rotating; when the retainer moves relative to the housing, the second protrusion can move outside the space, and the counting ramp of the first protrusion can move in contact with the transmission ramp to make the counting screw rotate.

12. The dual-powered drug delivery device according to claim 1, characterized in that, The dual-power drug delivery device also includes a manual trigger, which is linked to the retainer via a wedge mechanism. The wedge mechanism can convert the force of the manual trigger moving in a first preset direction into a force that drives the retainer to move in its axial direction.

13. The dual-powered drug delivery device according to claim 12, characterized in that, The wedge mechanism includes a first trigger ramp located on the manual trigger and a second trigger ramp located on the retainer, the first trigger ramp and the second trigger ramp being in contact.

14. The dual-powered drug delivery device according to claim 12, characterized in that, The wedge mechanism includes a first trigger ramp located on one of the manual trigger and the retainer, and a curved surface located on the other, the first trigger ramp contacting the curved surface line.

15. The dual-powered drug delivery device according to claim 12, characterized in that, The manual trigger is used to trigger the retainer to move toward the nose socket. The manual trigger is mounted on the housing and includes multiple finger placement portions.

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