Response type self-driven motor core-shell microneedle for treating intervertebral disc degeneration and preparation method and application thereof

By designing a responsive self-driven motor core-shell microneedle, a functional drug is pumped using an acidic microenvironment to generate bubbles. The core is loaded with anti-inflammatory drugs for time-sequential release, which solves the shortcomings of existing microneedle technology in drug delivery and mechanical properties. It achieves precise time-sequential control of multiple targets and promotes intervertebral disc repair.

CN121154513APending Publication Date: 2025-12-19THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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Patent Information

Application Number
CN202511260264.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-04
Publication Date
2025-12-19

AI Technical Summary

Technical Problem

Existing microneedle technology has difficulty achieving time-controlled release of multiple drug components when treating intervertebral disc degeneration. The drugs cannot reach the treatment site deeply and accurately. It has poor mechanical properties and cannot adapt to the biomechanical environment of multidimensional spinal movement. Furthermore, it lacks simultaneous intervention on the microenvironment and cellular behavior of annulus fibrosus degeneration.

Method used

Design a responsive self-driven motor core-shell microneedle. The shell contains a biodegradable material with bubble pump function and a metallophenolic network loaded with lactate oxidase. The core contains chitosan grafted with cyclodextrin/dihydrocaffeic acid and celecoxib. It utilizes an acidic microenvironment to generate bubble pumps to deliver functional drugs, while the core is loaded with anti-inflammatory drugs for timed release.

Benefits of technology

It achieves autonomous and precise drug treatment, reduces the accumulation of lactic acid and ROS in the microenvironment, restores cell vitality, promotes intervertebral disc repair, and adapts to the multidimensional biomechanical environment of the spine.

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Abstract

The invention discloses a response type self-driven motor core-shell microneedle for treating intervertebral disc degeneration and a preparation method and application thereof, and relates to the technical field of biological medicine. The core-shell microneedle comprises a shell layer and a core layer, the shell layer is a biodegradable shell layer, and the shell layer comprises ureido pyrimidone grafted gelatin UPy-Gel, a bubble pump NaHCO3, and a metal phenolic aldehyde network HCA-Se / LOX formed by 3, 4-dihydroxyphenylpropionic acid loaded with lactate oxidase and selenium dioxide; the core layer is prepared from cyclodextrin / dihydrocaffeic acid grafted chitosan (CS-HCA-CD) and celecoxib, and the cyclodextrin / dihydrocaffeic acid grafted chitosan (CS-HCA-CD) and the celecoxib; wherein the metal phenolic network HCA-Se / LOX formed by 3, 4-dihydroxyphenylpropionic acid loaded with lactate oxidase and selenium dioxide is prepared by the following steps: dissolving lactate oxidase and dihydrocaffeic acid in a selenium dioxide solution, adding polyvinylpyrrolidone and an ascorbic acid solution, and reacting to obtain the metal phenolic network HCA-Se / LOX formed by 3, 4-dihydroxyphenylpropionic acid loaded with lactate oxidase. The metal phenolic aldehyde network HCA-Se / LOX is formed by 2, 4-dihydroxyphenylpropionic acid and selenium dioxide.
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