Hydrogel eye pad for assisting in improving myopia and preparation method thereof

Abstract

The invention discloses a hydrogel eye pad for assisting in improving myopia and a preparation method thereof, and relates to the technical field of hydrogel eye pads, the eye pad comprises the following raw materials by mass: 10-15 parts of a hydrogel matrix including 3-5 parts of sodium carboxymethyl cellulose, 2-4 parts of polyvinyl alcohol, 1-2 parts of sodium hyaluronate, and 2-4 parts of sodium polyacrylate; 8-11 parts of an active functional component, including 1.8-2.2 parts of anthocyanin; 1.2 to 1.7 parts of xanthophyll; 5-8 parts of a composite plant extract; 74-82 parts of an auxiliary component, wherein the auxiliary component comprises 73-80 parts of deionized water; 0.6 to 1 part of a humectant; 0.3 to 0.6 part of a stabilizing agent; 0.1-0.3 part of a pH regulator, which is used for regulating the pH value to 6.0-7.0; and 0.1-0.2 part of a preservative. The hydrogel eye pad for assisting in improving myopia is synergistic in component, stable in process and high in comfort.

Description

Technical Field

[0001] This invention relates to the field of hydrogel eye patch technology, and in particular to a hydrogel eye patch for assisting in the improvement of myopia and its preparation method. Background Technology

[0002] Myopia is a prevalent vision problem worldwide, especially among teenagers, with its incidence rate rising year by year and showing a trend towards younger onset and increased severity. Current clinical correction methods mainly include optical correction (glasses, orthokeratology lenses), drug intervention (such as atropine), and surgical treatment, but these have limitations: optical correction can only relieve eye strain and control the rate of myopia progression, but cannot improve the physiological state of the eye; drug treatment has side effects such as photophobia and decreased accommodation; surgical treatment has strict limitations on age and corneal thickness, and carries risks of postoperative complications such as dry eye and glare. Eye care products (such as eye patches) have become an important means of assisting in improving eye health due to their convenience and safety. Most existing eye patches use non-woven fabric as a carrier, with the main ingredient being a single plant extract (such as Senecio scandens and wolfberry), achieving moisturizing or cooling effects through physical application. In recent years, hydrogel eye patches have gradually emerged, but their technology still has the following limitations: Insufficient carrier performance: Non-woven fabric carriers have low drug loading (usually <30%), uneven release of active ingredients, short moisturizing time (<4h), and are prone to falling off during application; Poor synergy of ingredients: Most existing products contain only 1-2 active ingredients and lack multi-target interventions targeting the pathological mechanisms of myopia (such as retinal oxidative damage, ciliary muscle spasm, and ocular microcirculation disorders). Process defects: Poor control of hydrogel cross-linking degree results in a texture that is too hard or too soft, affecting the stability of the patch; easily oxidized components (such as anthocyanins and lutein) lack protective measures and are easily degraded and ineffective.

[0003] Defects and shortcomings of existing technology: (1) Single ingredients and limited efficacy: Existing eye patches only target a single pathological process (such as moisturizing and cooling), without combining synergistic mechanisms such as anti-oxidation, improving microcirculation, and relieving ciliary muscle spasm, and therefore cannot achieve the effect of assisting in improving myopia. (2) Insufficient carrier performance: Non-woven fabric carriers have low drug loading rate (<30%) and fast release rate (>80% within 1 hour), resulting in low utilization of effective ingredients; hydrogel carriers have cross-linking problems, and excessive hardness can easily irritate the eyes, while excessive softness will result in unstable application. (3) Poor stability of active ingredients: Anthocyanins, lutein and other easily oxidized ingredients lack protection, and the degradation rate is >40% during preparation and storage, which reduces the efficacy of the product; (4) Insufficient comfort and safety: Non-woven fabrics have poor breathability (breathability < 200g / (m²·24h)), which can easily cause a stuffy feeling when applied; some products contain preservatives and irritating ingredients, which may pose an allergy risk. Summary of the Invention

[0004] This invention provides a hydrogel eye patch for assisting in the improvement of myopia and its preparation method. By optimizing the hydrogel matrix formulation, compounding multi-target active ingredients, and improving the preparation process, a hydrogel eye patch for assisting in the improvement of myopia is provided, which has synergistic components, stable process, and high comfort.

[0005] According to one aspect of this disclosure, a hydrogel eye patch for assisting in the improvement of myopia is provided, the raw material composition of which is as follows in parts by weight: The hydrogel matrix consists of 10-15 parts, including: 3-5 parts sodium carboxymethyl cellulose, 2-4 parts polyvinyl alcohol, 1-2 parts sodium hyaluronate, and 2-4 parts sodium polyacrylate. The active functional ingredients consist of 8-11 parts, including: 1.8-2.2 parts anthocyanins; 1.2-1.7 parts lutein; and 5-8 parts compound plant extract. The auxiliary ingredients are 74-82 parts, including: 73-80 parts deionized water; 0.6-1 part humectant; 0.3-0.6 parts stabilizer; 0.1-0.3 parts pH adjuster to adjust the pH to 6.0-7.0; and 0.1-0.2 parts preservative.

[0006] In one possible implementation, the anthocyanin is bilberry extract with a purity ≥95%.

[0007] In one possible implementation, the compound plant extract is prepared by extracting ginseng, Senecio scandens, Buddleja officinalis, peppermint, borneol, cassia seed, and black goji berry in a weight ratio of 1.2:1.2:1.0:0.8:0.8:0.6:0.6.

[0008] In one possible implementation, the stabilizer is a vitamin; the pH adjuster is citric acid or sodium hydroxide; and the preservative is phenoxyethanol that meets cosmetic hygiene standards. The moisturizer is glycerin.

[0009] A method for preparing a hydrogel eye patch for assisting in improving myopia, the method comprising: ① Preparation of compound plant extract: Pretreatment: Crush the mixed raw materials through an 80-mesh sieve, and add 8-10 times the weight of the mixed raw materials in a 50% ethanol aqueous solution; Ultrasonic extraction: The pretreated mixed solution was ultrasonically extracted twice at 40-50℃ and 300-400W power, for 30-40 minutes each time, and the extracts from the two extractions were combined. Purification and concentration: The extract was filtered using a 0.45μm filter membrane and concentrated under reduced pressure of -0.08 to -0.09MPa at 50-60℃ to obtain an extract with a relative density of 1.10-1.15. The concentrated extract was cooled to 23-25℃ and dissolved in 4 times the amount of water to obtain the compound plant extract. ②Preparation of hydrogel eye patches: Matrix dissolution: Add the hydrogel matrix components to 3 times the weight of the hydrogel matrix in deionized water, and stir at 300-500 rpm for 8-12 minutes until dissolved; Dispersion of active ingredients: Anthocyanins, lutein, and vitamins are added to a humectant and homogenized to obtain an active ingredient dispersion. Mixed crosslinking: Mix the active ingredient dispersion, compound plant extract, gel matrix, and remaining deionized water (40% of the total deionized water). After adjusting the pH, add the preservative, vacuum -0.085~-0.095MPa, stir in a star shape for 8-10 minutes, and then coat it onto non-woven fabric. The hydrogel coating thickness is 3.0-3.4mm. Cut it into 720mm long sheets and place them in the crosslinking curing chamber. The curing chamber temperature is 30-35℃, the humidity is 40-50%, and the crosslinking is allowed to stand for 3.5-4.5 hours. Packaging: Blister packaging after laser cutting and forming.

[0010] In one possible implementation, the mixed ingredients include: ginseng, Senecio scandens, Buddleja officinalis, peppermint, borneol, cassia seed, and black goji berry.

[0011] In one possible implementation, the rotation speed during homogeneous dispersion of the active ingredient is 400-600 rpm for 10-15 minutes.

[0012] Compared with the prior art, the beneficial effects of the present invention are: 1. Synergistic effects of ingredients and multi-target intervention: Anthocyanins (antioxidant, protect retinal photoreceptor cells), lutein (filter blue light, inhibit macular degeneration) and compound plant extracts (Senecio scandens for clearing heat and detoxifying, Cassia tora for clearing liver and improving eyesight, and ginseng for improving microcirculation) work synergistically to improve myopia-related pathological mechanisms from multiple targets such as oxidative damage, ciliary muscle spasm, and microcirculatory disorders.

[0013] 2. Advanced technology and high stability: The hydrogel matrix loading rate is ≥90%, the moisturizing time is ≥8h, and the active ingredients are slowly released (6-8h); low-temperature ultrasonic extraction preserves the activity of plant components, and vitamin stabilization treatment makes the degradation rate of anthocyanins and lutein <10%.

[0014] 3. Excellent comfort and safety: The hydrogel texture is soft and conforms to the contour of the eye, adapting to different eye shapes and is not easy to fall off. It has a breathability of ≥500g / (m²·24h) and is non-irritating. 4. Clearly effective: Continuous use for 3 months can slow down the rate of myopia progression in 85% of patients (≤5 degrees per month) and relieve eye strain symptoms in 95% of patients. Attached Figure Description

[0015] Figure 1 The diagram shows a flowchart of a method for preparing a hydrogel eye patch for assisting in the improvement of myopia, according to an embodiment of the present disclosure. Detailed Implementation

[0016] Various exemplary embodiments, features, and aspects of this disclosure will now be described in detail with reference to the accompanying drawings. The same reference numerals in the drawings denote elements that have the same or similar functions. Although various aspects of the embodiments are shown in the drawings, they are not necessarily drawn to scale unless specifically indicated otherwise.

[0017] The term “exemplary” as used herein means “serving as an example, embodiment, or illustration.” Any embodiment illustrated herein as “exemplary” is not necessarily to be construed as superior to or better than other embodiments.

[0018] Furthermore, to better illustrate this disclosure, numerous specific details are set forth in the following detailed description. Those skilled in the art will understand that this disclosure can be practiced without certain specific details. In some instances, methods, means, components, and circuits well known to those skilled in the art have not been described in detail in order to highlight the main points of this disclosure.

[0019] 1. Raw material composition: 12 parts hydrogel matrix (4 parts sodium carboxymethyl cellulose, 3 parts polyvinyl alcohol, 1.5 parts sodium hyaluronate, 3.5 parts sodium polyacrylate); 10 parts active functional ingredients (2 parts anthocyanins, 1.5 parts lutein, 6.5 parts compound plant extract); 78 parts auxiliary ingredients (76.4 parts deionized water, 0.8 parts moisturizer, 0.5 parts vitamins, 0.2 parts citric acid, 0.1 parts phenoxyethanol).

[0020] 2. Preparation ① Preparation of compound plant extract: Pretreatment: Crush the mixed raw materials (black goji berries, cassia seeds, etc.) through an 80-mesh sieve, and add 8-10 times the weight of the mixed raw materials in a 50% ethanol aqueous solution; Ultrasonic extraction: Ultrasonic extraction was performed twice at 45℃ and 350W power, for 35 minutes each time, and the extracts from the two extractions were combined. Purification and concentration: Filter through a 0.45μm filter membrane and concentrate at 55℃ under reduced pressure of -0.08 to -0.09MPa to obtain an extract with a relative density of 1.10-1.15. Cool the concentrated extract to 24℃ and dissolve it in 4 times the amount of water to obtain the compound plant extract.

[0021] ②Preparation of hydrogel eye patches: Matrix dissolution: Add the hydrogel matrix components to 3 times the weight of the hydrogel matrix in deionized water, and stir at 400 rpm for 10 minutes until dissolved; Active ingredient dispersion: Anthocyanins, lutein, and vitamins were added to a humectant and homogenized (500 rpm, 13 min). Mixed crosslinking: The active ingredient dispersion, compound plant extract, gel matrix, and remaining deionized water are mixed, citric acid is added to adjust the pH to 6.5, preservatives are added, and the mixture is vacuumed at -0.09 MPa and stirred in a star shape for 9 minutes. The mixture is then coated onto nonwoven fabric with a hydrogel coating thickness of 3.2 mm. The coating is cut into 720 mm long pieces and placed in a crosslinking curing chamber at a temperature of 33°C and a humidity of 45% for 4 hours of static crosslinking. Packaging: After laser cutting and shaping, the mixture is packaged in blister packs.

[0022] The various embodiments of this disclosure have been described above. These descriptions are exemplary and not exhaustive, nor are they limited to the disclosed embodiments. Many modifications and variations will be apparent to those skilled in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen to best explain the principles, practical application, or technical improvements to the embodiments in the market, or to enable others skilled in the art to understand the embodiments disclosed herein.

Claims

1. A hydrogel eye patch for assisting in improving myopia, characterized in that, The raw material composition of the eye patch, in parts by weight, is as follows: The hydrogel matrix consists of 10-15 parts, including: 3-5 parts sodium carboxymethyl cellulose, 2-4 parts polyvinyl alcohol, 1-2 parts sodium hyaluronate, and 2-4 parts sodium polyacrylate. The active functional ingredients consist of 8-11 parts, including: 1.8-2.2 parts anthocyanins; 1.2-1.7 parts lutein; and 5-8 parts compound plant extract. The auxiliary ingredients are 74-82 parts, including: 73-80 parts deionized water; 0.6-1 part humectant; 0.3-0.6 parts stabilizer; 0.1-0.3 parts pH adjuster to adjust the pH to 6.0-7.0; and 0.1-0.2 parts preservative.

2. The hydrogel eye patch for assisting in improving myopia according to claim 1, characterized in that, The anthocyanins are blueberry extracts with a purity of ≥95%.

3. The hydrogel eye patch for assisting in improving myopia according to claim 1, characterized in that, The compound plant extract is made from ginseng, Senecio scandens, Buddleja officinalis, peppermint, borneol, cassia seed, and black goji berry in a weight ratio of 1.2:1.2:1.0:0.8:0.8:0.6:0.

6.

4. A hydrogel eye patch for assisting in improving myopia according to claim 1, characterized in that, The stabilizer is a vitamin; the pH adjuster is citric acid or sodium hydroxide; the preservative is phenoxyethanol that meets cosmetic hygiene standards. The moisturizer is glycerin.

5. A method for preparing a hydrogel eye patch for assisting in improving myopia, characterized in that, The method is used to prepare the eye patch according to any one of claims 1-4, the method comprising: ① Preparation of compound plant extract: Pretreatment: Crush the mixed raw materials through an 80-mesh sieve, and add 8-10 times the weight of the mixed raw materials in a 50% ethanol aqueous solution; Ultrasonic extraction: The pretreated mixed solution was ultrasonically extracted twice at 40-50℃ and 300-400W power, for 30-40 minutes each time, and the extracts from the two extractions were combined. Purification and concentration: The extract was filtered using a 0.45μm filter membrane and concentrated under reduced pressure of -0.08 to -0.09MPa at 50-60℃ to obtain an extract with a relative density of 1.10-1.

15. The concentrated extract was cooled to 23-25℃ and dissolved in 4 times the amount of water to obtain the compound plant extract. ②Preparation of hydrogel eye patches: Matrix dissolution: Add the hydrogel matrix components to 3 times the weight of the hydrogel matrix in deionized water, and stir at 300-500 rpm for 8-12 minutes until dissolved; Dispersion of active ingredients: Anthocyanins, lutein, and vitamins are added to a humectant and homogenized to obtain an active ingredient dispersion. Mixed crosslinking: Mix the active ingredient dispersion, compound plant extract, gel matrix, and remaining deionized water. After adjusting the pH, add preservatives, vacuum at -0.085 to -0.095 MPa, stir in a star pattern for 8-10 minutes, and then coat it onto non-woven fabric. The hydrogel coating thickness is 3.0-3.4 mm. Cut it into 720 mm long sheets and place them in a crosslinking curing chamber. The curing chamber temperature is 30-35℃ and the humidity is 40-50%. Let it stand for crosslinking for 3.5-4.5 hours. Packaging: Blister packaging after laser cutting and forming.

6. The method for preparing a hydrogel eye patch for assisting in improving myopia according to claim 5, characterized in that, The mixed ingredients include: ginseng, Senecio scandens, Buddleja officinalis, peppermint, borneol, cassia seed, and black goji berry.

7. The method for preparing a hydrogel eye patch for assisting in improving myopia according to claim 5, characterized in that, During the homogenization dispersion of the active ingredients, the rotation speed is 400-600 rpm for 10-15 minutes.

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