Blood purification device

Abstract

In the blood purification device (100), in a pre-charge step, a vein-side on-off valve (112v) is closed while a vein connector (119) is connected to a connection port (161), and a pre-charge liquid (10) is stored in a vein-side air collection chamber (117) in a state in which a section downstream of the vein-side air collection chamber (117) in a vein-side blood circuit (112) is replaced by air, whereby the liquid level can be adjusted.

Description

TECHNICAL FIELD

[0001] The present application relates to a blood purification apparatus. BACKGROUND

[0002] As a prior art document disclosing a liquid level control method of a drip chamber connected to an extracorporeal circulation circuit of blood, there is Japanese Patent Application Laid-Open No. 09-164197 (Patent Document 1). In the liquid level control method of the drip chamber described in Patent Document 1, while preventing substantial expansion of the extracorporeal circulation circuit due to pressure, fluid is supplied to the drip chamber in a state where a discharge valve and an air valve connected to the drip chamber are closed. In this state, the pressure of the drip chamber is detected by a pressure sensor to rise to a set pressure. When the liquid level of the drip chamber rises to a set level, the supply of the fluid is stopped and the air valve is opened, and the pressurized air accumulated in the drip chamber is discharged with the air valve. It is detected that the drip chamber is in a non-pressurized state, the air valve is closed and the discharge valve is opened, and then the fluid is supplied, and the fluid is discharged from the discharge valve while the drip chamber is maintained at a prescribed liquid level.

[0003] PRIOR ART DOCUMENT

[0004] PATENT DOCUMENT

[0005] Patent Document 1: Japanese Patent Application Laid-Open No. 09-164197 SUMMARY

[0006] PROBLEMS TO BE SOLVED BY THE INVENTION

[0007] In the liquid level control method of the drip chamber described in Patent Document 1, since the liquid level of the drip chamber is grasped as a function of the pressure in the drip chamber, if the liquid level before adjustment is not stably maintained at the set level, the liquid level cannot be accurately adjusted.

[0008] The present application has been achieved in view of the above problems, and aims to provide a blood purification apparatus capable of adjusting the liquid level of a drip chamber without being affected by variation of the liquid level before adjustment.

[0009] TECHNICAL SOLUTION

[0010] The blood purification device according to the present application is provided with a blood purifier, an arterial side blood circuit, a venous side blood circuit, a dialysate supply source, a dialysate line, a blood pump, a priming liquid line, a venous side air trap chamber, a venous connector, a venous side on-off valve, a dialysate pump, a connection port, and a venous side air supply and exhaust line. The arterial side blood circuit is connected to the blood purifier and is provided so as to cause blood to flow into the blood purifier. The venous side blood circuit is connected to the blood purifier and is provided so as to cause blood to flow out from the blood purifier. The dialysate supply source supplies fresh dialysate. The dialysate line is connected to the dialysate supply source and enables fresh dialysate supplied from the dialysate supply source and used dialysate used in the blood purifier to flow. The blood pump is provided in the arterial side blood circuit and transports blood. The priming liquid line is connected to the arterial side blood circuit and supplies priming liquid. The venous side air trap chamber is provided in the venous side blood circuit. The venous connector is provided in the venous side blood circuit and is capable of being connected to a vein. The venous side on-off valve is provided in the venous side blood circuit at a position downstream of the venous side air trap chamber and is capable of opening and closing the venous side blood circuit. The dialysate pump is provided in the dialysate line and is capable of transporting fresh dialysate and used dialysate. The connection port is provided in the dialysate line and is capable of being connected to the venous connector. The venous side air supply and exhaust line is connected to the venous side air trap chamber and is capable of exhausting air in the venous side air trap chamber and capable of supplying air into the venous side air trap chamber. By driving the dialysate pump in a priming process, fresh dialysate and used dialysate are caused to flow intermittently through the dialysate line. The blood purification device, in the priming process, stores priming liquid in the venous side air trap chamber in a state in which the interval of the venous side blood circuit downstream of the venous side air trap chamber is replaced with air while the venous side on-off valve is closed and the venous connector is connected to the connection port, and thereby enables adjustment of the liquid level.

[0011] In one embodiment of the present application, the blood purification device performs a first priming process, a second priming process, a third priming process, a fourth priming process, and a fifth priming process in the above-described priming process. In the first priming process, the venous connector is connected to the connection port, the venous side on-off valve is opened, and the blood pump is driven in the forward direction, thereby priming until a certain amount of priming solution is stored in the venous side air trap chamber. In the second priming process, which is performed after the first priming process, the blood pump is stopped, air is supplied from the venous side air supply and exhaust line to the venous side air trap chamber, and the venous side air trap chamber and the above-described section of the venous side blood circuit downstream of the venous side air trap chamber are replaced with air. In the third priming process, which is performed after the second priming process, the venous side on-off valve is closed, the air supply from the venous side air supply and exhaust line to the venous side air trap chamber is stopped, and the venous side air trap chamber is maintained at atmospheric pressure via the venous side air supply and exhaust line. In the fourth priming process, which is performed after the third priming process, the blood pump is driven in the forward direction or the air in the venous side air trap chamber is exhausted from the venous side air supply and exhaust line, and the priming solution is stored in the venous side air trap chamber, thereby adjusting the liquid level. In the fifth priming process, which is performed after the fourth priming process, the venous side on-off valve is opened, and the section of the venous side blood circuit from the venous side on-off valve to the venous connector is primed.

[0012] In one embodiment of the present application, the blood purification device further includes a viscous liquid chamber provided in the dialysate line and capable of storing fresh dialysate and used dialysate. The dialysate pump is connected to the viscous liquid chamber and capable of delivering fresh dialysate and used dialysate.

[0013] Effects of the Invention

[0014] According to the present application, the liquid level of the drip chamber can be adjusted without being affected by the variation of the liquid level before adjustment. BRIEF DESCRIPTION OF DRAWINGS

[0015] Figure 1 FIG. 1 is a circuit diagram showing the configuration of a blood purification device according to an embodiment of the present application.

[0016] Figure 2 FIG. 2 is a circuit diagram showing the state in which the first priming process is performed in the blood purification device according to the embodiment of the present application.

[0017] Figure 3 FIG. 3 is a circuit diagram showing the state in which the second priming process is performed in the blood purification device according to the embodiment of the present application.

[0018] Figure 4 FIG. 4 is a circuit diagram showing the state in which the third priming process is performed in the blood purification device according to the embodiment of the present application.

[0019] Figure 5is a circuit diagram showing a state in which a fourth priming process is executed in the blood purification device of one embodiment of the present application.

[0020] Figure 6 is a circuit diagram showing a state in which a fifth priming process is executed in the blood purification device of one embodiment of the present application. DETAILED DESCRIPTION

[0021] Hereinafter, a blood purification device of one embodiment of the present application will be described with reference to the drawings. In the description of the following embodiments, the same or equivalent portions in the drawings are denoted by the same symbols, and will not be described repeatedly.

[0022] In the description of the following embodiments, as the blood purification device, a blood purification device for continuous renal replacement therapy (CRRT) will be described. However, the blood purification device can be a blood purification device for any one of continuous hemodiafiltration (CHDF), continuous hemofiltration (CHF), continuous hemodialysis (CHD), and slow continuous ultrafiltration (SCUF).

[0023] Figure 1 is a circuit diagram showing the structure of the blood purification device of one embodiment of the present application. As shown in Figure 1 the blood purification device 100 of one embodiment of the present application includes a blood purification apparatus 120, an arterial side blood circuit 111, a venous side blood circuit 112, a dialysate supply source 150, a dialysate line 160, a blood pump 113, a priming liquid line 130, a venous side air trap 117, a venous connector 119, a venous side on-off valve 112v, a dialysate pump, a connection port 161, and a venous side air supply and exhaust line 118.

[0024] In this embodiment, the blood purification device 100 further includes an arterial side air trap 114, an arterial connector 116, an arterial side air supply and exhaust line 115, an arterial side air valve 115v, a venous side air valve 118v, an arterial side pressure measuring device 114P, a venous side pressure measuring device 117P, a priming liquid supply source 140, a priming on-off valve 130v, an atmospheric air opening valve 21v, an air pump 21p, an arterial side protection filter 115f, a venous side protection filter 118f, a first powder dissolving device 151, and a second powder dissolving device 152. At least one of these structures need not necessarily be provided.

[0025] The blood purifier 120 internally contains a semipermeable membrane composed of, for example, a hollow fiber membrane. The blood purifier 120 has a blood inlet 121 and a blood outlet 122. The arterial side blood circuit 111 is connected to the blood inlet 121. The venous side blood circuit 112 is connected to the blood outlet 122.

[0026] A blood pump 113 that pumps blood is provided in the arterial side blood circuit 111. An arterial side air trap chamber 114 is provided in the arterial side blood circuit 111 between the blood pump 113 and the blood purifier 120. An arterial side pressure measuring device 114P that measures the pressure in the arterial side air trap chamber 114 is provided in the arterial side air trap chamber 114. An arterial side protection filter 115f is provided between the arterial side air trap chamber 114 and the arterial side pressure measuring device 114P.

[0027] An arterial connector 116 is provided in the arterial side blood circuit 111 and can be connected to an artery. Blood collected from the artery of a patient through the arterial connector 116 flows through the arterial side blood circuit 111 and is measured for pressure as it passes through the arterial side air trap chamber 114, and then flows into the blood purifier 120 from the blood inlet 121. The arterial side air trap chamber 114 is provided to prevent air from mixing into the blood in the arterial side blood circuit 111.

[0028] A venous side air trap chamber 117 is provided in the venous side blood circuit 112. A venous side pressure measuring device 117P that measures the pressure in the venous side air trap chamber 117 is provided in the venous side air trap chamber 117. A venous side protection filter 118f is provided between the venous side air trap chamber 117 and the venous side pressure measuring device 117P. A venous side on-off valve 112v that can open and close the venous side blood circuit 112 is provided in the venous side blood circuit 112 at a position downstream of the venous side air trap chamber 117.

[0029] A venous connector 119 is provided in the venous side blood circuit 112 and can be connected to a vein. Blood purified by the blood purifier 120 flows through the venous side blood circuit 112 and is measured for pressure as it passes through the venous side air trap chamber 117, and then returns to the vein of a patient through the venous connector 119. The venous side air trap chamber 117 is provided to prevent air from mixing into the blood in the venous side blood circuit 112.

[0030] The blood purifier 120 also has a dialysate inlet 124 and a dialysate outlet 123. A first connection line 181 is connected to the dialysate inlet 124. A second connection line 182 is connected to the dialysate outlet 123.

[0031] The pre-charging line 130 is connected to the arterial side blood circuit 111, and supplies the pre-charging liquid 10. The pre-charging liquid 10 is physiological saline or the like. The end portion of the upstream side of the pre-charging line 130 is connected to a pre-charging liquid supply source 140. The pre-charging liquid supply source 140 is a bag that stores physiological saline or the like. A pre-charging opening and closing valve 130v that opens and closes the pre-charging line 130 is provided in the pre-charging line 130.

[0032] The arterial side air supply and discharge line 115 is connected to the arterial side air trap chamber 114. An arterial side air valve 115v that can open and close the arterial side air supply and discharge line 115 is provided in the arterial side air supply and discharge line 115. The arterial side air supply and discharge line 115 is configured to be able to discharge air in the arterial side air trap chamber 114 and to be able to supply air to the arterial side air trap chamber 114.

[0033] The venous side air supply and discharge line 118 is connected to the venous side air trap chamber 117. A venous side air valve 118v that can open and close the venous side air supply and discharge line 118 is provided in the venous side air supply and discharge line 118. The venous side air supply and discharge line 118 is configured to be able to discharge air in the venous side air trap chamber 117 and to be able to supply air to the venous side air trap chamber 117.

[0034] The section of the arterial side air supply and discharge line 115 on the downstream side of the arterial side air valve 115v and the section of the venous side air supply and discharge line 118 on the downstream side of the venous side air valve 118v are connected to each other by a connection line 20. An atmospheric air opening valve 21v is provided at a position in the arterial side air supply and discharge line 115 on the downstream side of the connection portion with the connection line 20. An air pump 21p is provided at a position in the venous side air supply and discharge line 118 on the downstream side of the connection portion with the connection line 20. Alternatively, the positions of the atmospheric air opening valve 21v and the air pump 21p can be exchanged.

[0035] By providing the arterial side air valve 115v, the venous side air valve 118v, the atmospheric air opening valve 21v, and the air pump 21p, the arterial side air supply and discharge line 115 is able to discharge air in the arterial side air trap chamber 114 and to supply air to the arterial side air trap chamber 114, and the venous side air supply and discharge line 118 is able to discharge air in the venous side air trap chamber 117 and to supply air to the venous side air trap chamber 117.

[0036] The arterial side protection filter 115f and the venous side protection filter 118f each have a function of preventing blood from flowing out of the blood circuit and a function of preventing infection from a pressure measuring device.

[0037] The dialysate supply source 150 supplies fresh dialysate. The fresh dialysate is prepared by mixing reverse osmosis water, a first stock solution, and a second stock solution in the dialysate supply source 150.

[0038] The first stock solution is a liquid preparation prepared by dissolving a first powder, which is a part of the solute component of fresh dialysate, in water. The first powder contains, for example, at least any one of a calcium salt, a magnesium salt, a potassium salt, a sodium salt, and glucose. The first stock solution is prepared by the first powder dissolving device 151. Alternatively, the first stock solution can be stored in the first stock solution tank in a pre-prepared state, instead of being prepared by the first powder dissolving device 151.

[0039] The second stock solution is a liquid preparation prepared by dissolving a second powder, which is another part of the solute component of fresh dialysate, in water. The second powder contains, for example, at least sodium bicarbonate. The second stock solution is prepared by the second powder dissolving device 152. Alternatively, the second stock solution can be stored in the second stock solution tank in a pre-prepared state, instead of being prepared by the second powder dissolving device 152.

[0040] The dialysate supply source 150 is connected to the first powder dissolving device 151 and the second powder dissolving device 152. The first stock solution is supplied from the first powder dissolving device 151 to the dialysate supply source 150. The second stock solution is supplied from the second powder dissolving device 152 to the dialysate supply source 150. Alternatively, in the case where the first stock solution is stored in the first stock solution tank, the first stock solution is supplied from the first stock solution tank to the dialysate supply source 150. In the case where the second stock solution is stored in the second stock solution tank, the second stock solution is supplied from the second stock solution tank to the dialysate supply source 150.

[0041] The dialysate line 160 is connected to the dialysate supply source 150, so that fresh dialysate supplied from the dialysate supply source 150 and used dialysate used in the blood purification device 120 can flow. A dialysate pump capable of transporting fresh dialysate and used dialysate is provided in the dialysate line 160.

[0042] In the present embodiment, the blood purification device 100 is provided with a viscous fluid control system 170 including a first chamber 171, a second chamber 172, and a viscous pump 173 as a dialysate pump. The viscous fluid control system 170 is provided in the dialysate line 160. Alternatively, the dialysate pump is not limited to the viscous pump 173, as long as it is capable of transporting fresh dialysate and used dialysate.

[0043] The first chamber 171 and the second chamber 172 are each a viscous fluid chamber. The viscous fluid chamber includes a fresh dialysate chamber, a used dialysate chamber, and a viscous fluid chamber. The volume of the fresh dialysate chamber and the used dialysate chamber can be adjusted by causing silicon oil to enter and exit the viscous fluid chamber by the viscous pump 173.

[0044] The first connection line 181 is a line for supplying fresh dialysate to the blood purification device 120. The first connection line 181 connects the blood purification device 120 and the viscous fluid control system 170. Specifically, the first connection line 181 connects the dialysate inlet 124 of the blood purification device 120 and each fresh dialysate chamber of the first chamber 171 and the second chamber 172 of the viscous fluid control system 170.

[0045] The first chamber 171 and the second chamber 172 each have a first on-off valve. When the first on-off valve of the first chamber 171 is in an open state, the first on-off valve of the second chamber 172 is in a closed state. When the first on-off valve of the first chamber 171 is in a closed state, the first on-off valve of the second chamber 172 is in an open state. The first connection line 181 is connected to the fresh dialysate chamber via the first on-off valve in the first chamber 171 and the first on-off valve in the second chamber 172. Thus, the first connection line 181 is alternately connected to each fresh dialysate chamber of the first chamber 171 and the second chamber 172.

[0046] The second connection line 182 is a line for flowing used dialysate used in the blood purification device 120. The second connection line 182 connects the blood purification device 120 and the viscous fluid control system 170. Specifically, the second connection line 182 connects the dialysate outlet 123 of the blood purification device 120 and each used dialysate chamber of the first chamber 171 and the second chamber 172 of the viscous fluid control system 170.

[0047] The first chamber 171 and the second chamber 172 each have a second on-off valve. When the second on-off valve of the first chamber 171 is in an open state, the second on-off valve of the second chamber 172 is in a closed state. When the second on-off valve of the first chamber 171 is in a closed state, the second on-off valve of the second chamber 172 is in an open state. The second connection line 182 is connected to the used dialysate chamber via the second on-off valve in the first chamber 171 and the second on-off valve in the second chamber 172. Thus, the second connection line 182 is alternately connected to each used dialysate chamber of the first chamber 171 and the second chamber 172.

[0048] As described above, the blood purification device 100 of the present embodiment is provided with the viscous fluid chamber provided in the dialysate line 160 and capable of storing fresh dialysate and used dialysate. The first chamber 171 and the second chamber 172 store fresh dialysate supplied from the dialysate supply source 150 in the fresh dialysate chamber. The first chamber 171 and the second chamber 172 store used dialysate used in the blood purification device 120 in the used dialysate chamber.

[0049] The dialysate pump is a viscous pump 173 connected to the viscous liquid chamber, which can deliver fresh dialysate and used dialysate. By driving the viscous pump 173 in the forward direction, the silicone oil moves from the viscous liquid chamber of the first chamber 171 to the viscous liquid chamber of the second chamber 172. As a result, negative pressure is generated in the fresh dialysate chamber and the used dialysate chamber of the first chamber 171, respectively. On the other hand, positive pressure is generated in the fresh dialysate chamber and the used dialysate chamber of the second chamber 172, respectively.

[0050] As a result, fresh dialysate supplied from the dialysate supply source 150 flows into the fresh dialysate chamber of the first chamber 171, and used dialysate used in the blood purifier 120 flows into the used dialysate chamber of the first chamber 171 through the second connection line 182.

[0051] Next, by driving the viscous pump 173 in the reverse direction, the silicone oil moves from the viscous liquid chamber of the second chamber 172 to the viscous liquid chamber of the first chamber 171. As a result, negative pressure is generated in the fresh dialysate chamber and the used dialysate chamber of the second chamber 172, respectively. On the other hand, positive pressure is generated in the fresh dialysate chamber and the used dialysate chamber of the first chamber 171, respectively.

[0052] As a result, fresh dialysate supplied from the dialysate supply source 150 flows into the fresh dialysate chamber of the second chamber 172, and used dialysate used in the blood purifier 120 flows into the used dialysate chamber of the second chamber 172 through the second connection line 182. The viscous pump 173 alternately repeats the forward direction driving and the reverse direction driving. As a result, fresh dialysate and used dialysate intermittently flow through the dialysate line 160.

[0053] The connection port 161 is provided to the dialysate line 160, which can be connected to the venous connector 119. In the present embodiment, the connection port 161 is provided to a position in the dialysate line 160 on the downstream side from the dialysate pump. That is, the connection port 161, which can be connected to the venous connector 119, is provided to a position in the dialysate line 160 on the downstream side from the viscous liquid control system 170. When the connection port 161 is provided to a position in the dialysate line 160 on the downstream side from the second connection line 182, where the pressure fluctuation is larger, the function of the present application is effectively exerted. In addition, the connection port 161 can be provided to a position in the dialysate line 160 on the upstream side from the dialysate pump. By connecting the venous connector 119 to the connection port 161, the priming liquid 10 flowing into the venous side blood circuit 112 can be discharged to the dialysate line 160 through the venous connector 119 and the connection port 161.

[0054] The following describes the operation when the priming process is performed in the blood purification device 100 of the present embodiment. In the blood purification device 100 of the present embodiment, the fresh dialysate and the used dialysate are intermittently caused to flow through the dialysate line 160 by driving the dialysate pump during the priming process. By continuously driving the dialysate pump during the priming process, the mixed state of the first primary liquid and the second primary liquid can be kept constant, and the composition ratio of the fresh dialysate supplied from the dialysate supply source 150 can be stabilized.

[0055] The blood purification device 100 stores the priming liquid 10 in the venous-side air trap chamber 117 in a state where the section of the venous-side blood circuit 112 downstream of the venous-side air trap chamber 117 is air-displaced while the venous connector 119 is connected to the connection port 161 during the priming process, and thus the liquid level can be adjusted. Specifically, the blood purification device 100 performs the following first to fifth priming processes during the priming process.

[0056] Figure 2 is a circuit diagram showing a state where the first priming process is performed in the blood purification device of the present embodiment. As shown in Figure 2 , the venous connector 119 is connected to the connection port 161 when the priming process is performed.

[0057] In the first priming process, the venous-side on-off valve 112v is opened while the arterial-side gas valve 115v and the venous-side gas valve 118v are closed, and the blood pump 113 is driven in the forward direction, and thus the priming is performed until a certain amount of the priming liquid 10 is stored in the venous-side air trap chamber 117. In the first priming process, the priming on-off valve 130v is in the open state, the atmospheric air opening valve 21v is in the closed state, and the gas pump 21p is stopped.

[0058] In the first priming process, the viscous pump 173 as the dialysate pump is driven, and thus the pressure at the connection port 161 varies at a certain cycle, as a result of which the liquid level of the priming liquid 10 stored in the venous-side air trap chamber 117 varies up and down.

[0059] Figure 3 is a circuit diagram showing a state where the second priming process is performed in the blood purification device of the present embodiment. As shown in Figure 3In the second priming process, the blood pump 113 is stopped, the venous-side air valve 118v is opened, and air is supplied from the venous-side supply / discharge air line 118 into the venous-side air trap chamber 117 to replace the space in the venous-side air trap chamber 117 and the space in the venous-side blood circuit 112 downstream of the venous-side air trap chamber 117 with air. In the second priming process, the priming on / off valve 130v, the arterial-side air valve 115v, and the atmospheric air opening valve 21v are in the closed state, and the air pump 21p is driven in the forward direction to supply air into the venous-side air trap chamber 117.

[0060] In the second priming process, the priming liquid 10 stored in the venous-side air trap chamber 117 is discharged and replaced with air. The viscous pump 173, which functions as a dialysis pump, is driven so that the pressure at the connection port 161 fluctuates at a certain cycle, and as a result, the liquid level of the priming liquid 10 fluctuates in the space in the venous-side blood circuit 112 downstream of the venous-side air trap chamber 117. In addition, the space in the venous-side blood circuit 112 from the venous-side air trap chamber 117 to the venous connector 119 does not need to be completely replaced with air, and it is sufficient that the priming liquid 10 does not remain in the venous-side air trap chamber 117 when the pressure at the connection port 161 is the highest.

[0061] Figure 4 is a circuit diagram showing a state in which the third priming process is performed in the blood purification device according to the embodiment of the present application. As shown in Figure 4 In the third priming process, the venous-side on / off valve 112v is closed, and the supply of air into the venous-side air trap chamber 117 from the venous-side supply / discharge air line 118 is stopped, and the pressure in the venous-side air trap chamber 117 is maintained at atmospheric pressure through the venous-side supply / discharge air line 118. In the third priming process, the priming on / off valve 130v and the arterial-side air valve 115v are in the closed state, the venous-side air valve 118v and the atmospheric air opening valve 21v are in the open state, and the blood pump 113 and the air pump 21p are stopped.

[0062] In the third priming process, since the venous-side on / off valve 112v is closed, the pressure of the air in the venous-side air trap chamber 117 is maintained at atmospheric pressure without being affected by the fluctuation of the pressure at the connection port 161.

[0063] Figure 5 is a circuit diagram showing a state in which the fourth priming process is performed in the blood purification device according to the embodiment of the present application. As shown in Figure 5 In the fourth priming process, the blood pump 113 is driven in the forward direction to store the priming liquid 10 in the venous-side air trap chamber 117 to adjust the liquid level. In the fourth priming process, the priming on / off valve 130v, the arterial-side air valve 115v, the venous-side air valve 118v, and the atmospheric air opening valve 21v are in the open state, and the air pump 21p is stopped.

[0064] In addition, in the fourth priming process, instead of driving the blood pump 113 in the forward direction, the air in the venous-side air trap chamber 117 can be discharged from the venous-side air discharge line 118, thereby priming the priming liquid 10 from the venous-side blood circuit 112 and storing it in the venous-side air trap chamber 117 to adjust the liquid level. In this case, the venous-side air valve 118v is in the open state, the priming on-off valve 130v, the arterial-side air valve 115v, and the atmospheric air opening valve 21v are in the closed state, the blood pump 113 is stopped, and the air pump 21p is driven in the reverse direction to discharge the air in the venous-side air trap chamber 117.

[0065] In the fourth priming process, since the venous-side on-off valve 112v is closed, the priming liquid 10 in the venous-side air trap chamber 117 can be adjusted in the liquid level without being affected by the pressure variation at the connection port 161.

[0066] Figure 6 is a circuit diagram showing a state in which the fifth priming process is performed in the blood purification device according to the embodiment of the present application. As shown in Figure 6 In the fifth priming process, the venous-side on-off valve 112v is opened, and the section from the venous-side on-off valve 112v to the venous connector 119 in the venous-side blood circuit 112 is primed. In the fifth priming process, the arterial-side air valve 115v is in the closed state, the priming on-off valve 130v, the venous-side air valve 118v, and the atmospheric air opening valve 21v are in the open state, the blood pump 113 is driven in the forward direction, and the air pump 21p is stopped.

[0067] By priming as described above, the liquid level of the venous-side air trap chamber 117 can be adjusted without being affected by the variation in the liquid level of the venous-side air trap chamber 117 before adjustment caused by the pressure variation at the connection port 161 in the first priming process.

[0068] It should be understood that the embodiments disclosed herein are illustrative in all respects and are not restrictive. The scope of the present application is indicated by the claims rather than the description, and is intended to include all modifications equivalent in meaning and scope to the claims.

[0069] Explanation of Symbols

[0070] 10 priming solution, 20 connecting line, 21p gas pump, 21v atmospheric opening valve, 100 blood purification device, 111 arterial side blood circuit, 112 venous side blood circuit, 112v venous side opening and closing valve, 113 blood pump, 114 arterial side air trap chamber, 114P arterial side pressure measuring device, 115 arterial side air supply and exhaust line, 115f arterial side protection filter, 115v arterial side air valve, 116 arterial connector, 117 venous side air trap chamber, 117P venous side pressure measuring device, 118 venous side air supply and exhaust line, 118f venous side protection filter, 118v venous side air valve, 119 venous connector, 120 blood purification device, 121 blood inlet, 122 blood outlet, 123 dialysate outlet, 124 dialysate inlet, 130 priming solution line, 130v priming opening and closing valve, 140 priming solution supply source, 150 dialysate supply source, 151 first powder dissolving device, 152 second powder dissolving device, 160 dialysate line, 161 connecting port, 170 viscous liquid control system, 171 first chamber, 172 second chamber, 173 viscous pump, 181 first connecting line, 182 second connecting line.

Claims

1. A blood purification device, characterized in that, have: Blood purifier; An arterial blood circuit, which is connected to the blood purifier, is used to allow blood to flow into the blood purifier; A venous blood circuit, which is connected to the blood purifier, is used to allow blood to flow out of the blood purifier; The dialysate supply source provides fresh dialysate. A dialysate line, which is connected to the dialysate supply source, allows the flow of fresh dialysate supplied from the dialysate supply source and used dialysate used in the blood purifier. A blood pump, which is installed in the blood circuit on the arterial side, delivers blood; A pre-fill fluid line is connected to the arterial side blood circuit to supply pre-fill fluid; A vein-side air trapping chamber is disposed in the vein-side blood circuit; A vein connector, which is located on the vein-side blood circuit and can be connected to a vein; A vein-side on / off valve is located in the vein-side blood circuit at a position downstream of the vein-side air collection chamber, and is capable of opening and closing the vein-side blood circuit. A dialysate pump, which is installed in the dialysate pipeline, is capable of delivering the fresh dialysate and the used dialysate; A connection port, located in the dialysate tubing, is capable of connecting to the venous connector; and The venous side air supply and exhaust pipe is connected to the venous side air collection chamber, and is capable of exhausting air from the venous side air collection chamber and supplying air into the venous side air collection chamber. By driving the dialysate pump during the pre-filling process, the fresh dialysate and the used dialysate flow intermittently through the dialysate tubing. In the pre-filling process, the venous side on / off valve is closed while the venous connector is connected to the connection port. The pre-filling fluid is stored in the venous side air trap chamber while the section downstream of the venous side air trap chamber in the venous side blood circuit is replaced by air, thereby enabling the adjustment of the fluid level.

2. The blood purification device according to claim 1, characterized in that, The pre-charging process includes the execution of a first pre-charging process, a second pre-charging process, a third pre-charging process, a fourth pre-charging process, and a fifth pre-charging process. In the first pre-filling process, the vein connector is connected to the connection port, and the blood pump is driven to rotate forward while the vein-side on / off valve is opened, thereby performing pre-filling until a certain amount of pre-filling fluid is stored in the vein-side air collection chamber. The second pre-charging step, following the first pre-charging step, stops the blood pump and supplies air from the venous side supply and exhaust pipe into the venous side air collection chamber, replacing the venous side air collection chamber and the downstream section of the venous side blood circuit with air. The third pre-charging step, following the second pre-charging step, closes the vein-side on / off valve, stopping the air supply from the vein-side air supply and exhaust pipe to the vein-side air collection chamber, and maintains atmospheric pressure in the vein-side air collection chamber through the vein-side air supply and exhaust pipe. The fourth pre-filling step, following the third pre-filling step, drives the blood pump to rotate forward or discharges air from the venous-side air collection chamber through the venous-side supply and exhaust pipe, allowing the pre-filling fluid to be stored in the venous-side air collection chamber, thereby adjusting the fluid level. The fifth pre-charging step, following the fourth pre-charging step, involves opening the venous-side on / off valve to pre-charge the section of the venous-side blood circuit from the venous-side on / off valve to the venous connector.

3. The blood purification device according to claim 1 or 2, characterized in that, It also includes a viscous liquid chamber located in the dialysate pipeline, capable of storing both fresh and used dialysate. The dialysate pump is connected to the viscous liquid chamber and is a viscous pump capable of delivering both fresh dialysate and used dialysate.

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