Mineralized protein-based bionic bone repair material as well as preparation method and application thereof

Abstract

The invention relates to a mineralized protein-based bionic bone repair material as well as a preparation method and application thereof. Ca < 2 + > and PO4 < 3-> are introduced into the silk fibroin solution for a mineralization reaction, so that the amorphous calcium phosphate is directionally deposited on the silk fibroin molecular template, and a silk fibroin-amorphous calcium phosphate nano-composite is generated; after the mineralization reaction is finished, a mineralized product is centrifuged, frozen and freeze-dried, and the bionic bone repair material based on the mineralized protein is obtained. The bionic block material which is compact in structure and excellent in mechanical property can be constructed through high-pressure compression molding at normal temperature. The biomimetic bone repair material based on mineralized protein or a biomimetic block material further prepared on the basis of the scheme of the application shows excellent mechanical properties and structural stability in dry and wet environments, and also has good processability; the method is suitable for personalized bone defect repair and manufacturing of clinical orthopedic implantation instruments such as bone nails, bone plates and interbody fusion cages, and has wide application prospects and transformation values.

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