Multi-target ion and photon synchronous radiotherapy system

Abstract

The invention belongs to the field of tumor treatment, and particularly relates to a multi-target ion and photon synchronous radiotherapy system, which comprises a rotating seat for driving a human body to rotate, and an ion treatment module and a photon treatment module are arranged around the rotating seat; the release end of the ion treatment module is arranged towards the rotating seat, and the ion treatment module is used for outputting ion beams to the drug-resistant tumor target region; meanwhile, the release end of the photon treatment module is arranged towards the rotating seat, and the photon treatment module is used for outputting photon beams to the sensitive tumor target region; the rotating seat, the photon treatment module and the ion treatment module are in signal connection with the controller, and the controller is in signal connection with a treatment scheme planning module. The invention provides a multi-target-region ion and photon synchronous radiotherapy system, and aims to solve the problem that a conventional means cannot perform targeted treatment on a drug-resistant tumor region and a sensitive tumor region.

Description

TECHNICAL FIELD

[0001] The application belongs to the field of tumor treatment, and particularly relates to a multi-target region ion and photon synchronous radiotherapy system. BACKGROUND

[0002] As a malignant disease threatening human life and health worldwide, the incidence and mortality of tumors are on the rise. According to the statistics of the World Health Organization (WHO), there are more than 19 million new cases of malignant tumor patients every year, and the number of death cases accounts for 16% of the total number of deaths. Among them, lung cancer, breast cancer, colorectal cancer, liver cancer and other solid tumors, as well as leukemia, lymphoma and other hematological tumors are high-incidence types. With the aggravation of population aging, changes in lifestyle (such as high-fat diet, sedentary, smoking) and environmental pollution exposure, the disease spectrum of tumor is gradually complicated, and the proportion of cases of advanced, metastatic and multiple primary tumors is increasing year by year, which puts forward higher requirements for the precision, systematization and individualization of clinical treatment.

[0003] According to the applicant's clinical practice, it is found that by using a multi-point biomolecular imaging method, tumor cells in a tumor can be divided into a drug-resistant tumor cell region and a sensitive tumor cell region, and a plurality of sensitive and drug-resistant tumor target regions are constructed. The biological characteristics of drug-resistant tumor cells and sensitive tumor cells are different, and the inactivation of the drug-resistant tumor cell tumor target region is more difficult than that of the sensitive tumor cell tumor target region, which is also the main reason for the failure of current tumor treatment. The research background and related theories of this part can refer to some papers published by the present inventor in advance.

[0004] In the conventional tumor treatment process, the above two different biological characteristic tumor cell regions in an individual tumor cannot be distinguished and treated specifically, which leads to the problem of incomplete inactivation of drug-resistant tumor cells during tumor treatment, and further leads to the poor tumor treatment effect in the conventional method. SUMMARY

[0005] The present application provides a multi-target region ion and photon synchronous radiotherapy system, which aims to solve the problem that conventional tumor treatment cannot separately treat drug-resistant tumor regions and sensitive tumor regions.

[0006] In order to achieve the above object, the application provides a multi-target area ion and photon synchronous radiotherapy system, which comprises a rotating seat for driving the human body to rotate, an ion therapy module and a photon therapy module are arranged around the rotating seat; the release end of the ion therapy module is arranged towards the rotating seat, the ion therapy module is used for outputting an ion beam to a drug-resistant tumor target area, and the ion beam is used for inactivating the drug-resistant tumor target area; the release end of the photon therapy module is arranged towards the rotating seat, the photon therapy module is used for outputting a photon beam to a sensitive tumor target area, and the photon beam is used for inactivating the sensitive tumor target area; the rotating seat, the photon therapy module and the ion therapy module are signal connected to a controller, and a treatment plan module is signal connected to the controller.

[0007] The present application provides targeted treatment for the sensitive tumor target area through the photon therapy module, and targeted treatment for the drug-resistant tumor target area through the ion therapy module by maximizing the LET / RBE of the ion beam. The angle of the human body is adjusted through the rotating seat to ensure that the tumor of the human body can be completely covered and treated. The treatment plan module provides a cooperative control scheme for the photon beam, the ion beam, the rotating seat and the real-time image. The technical scheme of the present application provides accurate treatment for the sensitive tumor target area and the drug-resistant tumor target area, and has better treatment effect than the conventional treatment method in the prior art.

[0008] Preferably, in order to realize accurate treatment of the drug-resistant tumor target area, the scanning position, the dose rate and the output energy of the output end of the ion therapy module are adjustable, so as to adjust the LET / RBE and make the ion beam accurately act on the drug-resistant tumor target area. The scanning position, the dose rate and the output energy are adjusted, so that the ion beam can accurately act on the drug-resistant tumor target area, the accurate treatment of the drug-resistant tumor target area is realized by maximizing the LET / RBE, and the treatment effect is better.

[0009] Preferably, in order to realize accurate treatment of the sensitive tumor target area, the grating position and the metering rate of the output end of the photon therapy module are adjustable, so that the photon beam accurately acts on the sensitive tumor target area. The grating position and the metering rate are adjusted, so that the photon beam accurately acts on the sensitive tumor target area, and the accurate treatment of the sensitive tumor target area is realized.

[0010] Preferably, in order to monitor the position of the tumor target area and adjust the position of the seat, the present application further comprises an online real-time image module, which is arranged towards the rotating seat and is signal connected to the controller; the online real-time image module receives the control signal of the controller, monitors the position of the tumor target area in real time, returns the monitoring data to the controller, and the controller controls the working state change of the rotating seat, the ion therapy module and the photon therapy module.

[0011] The scheme obtains the three-dimensional image of the tumor through the online real-time image module, and the controller monitors the position of the tumor target area and adjusts the position of the seat according to the three-dimensional image, so as to facilitate accurate tumor treatment.

[0012] Preferably, since the human body is driven to rotate by the rotating seat, in order to obtain multi-angle images of the tumor target area during the rotation of the human body, the online real-time image module is provided as two, the two online real-time image modules are distributed at an included angle, and the two online real-time image modules cooperate to realize real-time monitoring of the position of the tumor target area.

[0013] The two online real-time image modules in the scheme can ensure multi-angle monitoring of the tumor target area during tumor treatment. At the same time, in order to reduce the mutual interference of the two online real-time image modules, the two online real-time image modules are distributed at an included angle.

[0014] Preferably, in order to obtain a three-dimensional image of the tumor target area, the online real-time image module includes an X-ray emitting device and a flat panel detector, the X-ray emitting device and the flat panel detector are oppositely arranged, and the rotating seat is located between the X-ray emitting device and the flat panel detector.

[0015] Preferably, the X-ray emitting device is a CT module unit or a CBCT module unit.

[0016] Preferably, in order to distinguish the drug-resistant tumor target area and the sensitive tumor target area, the scheme further includes a tumor multi-target area generation module, which is connected with the treatment plan module, and is used to obtain information of tumor cells and send the information to the treatment plan module.

[0017] In order to install the ion treatment module and the photon treatment module, the scheme further includes a treatment cabin, the rotating seat is arranged in the middle of the treatment cabin, and the photon treatment module and the ion treatment module are fixedly installed on the side wall of the treatment cabin.

[0018] Preferably, the tumor multi-target area generation module includes an organ image unit, a molecular image unit and a processor, the organ image unit is used to obtain position information of the tumor in the human body, the molecular image unit is used to obtain spatial density distribution information of the tumor cells, and the processor generates tumor target area information by the information obtained by the organ image unit and the molecular image unit and sends the information to the treatment plan module.

[0019] Preferably, in order to make the partitioning of drug-resistant tumor target areas of sensitive tumor target areas more accurate and avoid errors, the molecular imaging unit of this scheme acquires the spatial density distribution information of tumor cells before treatment and the spatial density distribution information of tumor cells after treatment with a predetermined dose.

[0020] The beneficial effects of this invention are as follows: This solution combines a photon therapy module and an ion therapy module, with the ion therapy module targeting drug-resistant tumors and the photon therapy module targeting sensitive tumors. Simultaneously, by rotating the seat, the photon and ion therapy beams can be precisely applied to the target area at different spatial angles. Compared to existing conventional tumor treatment methods, this solution offers superior tumor treatment. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of a multi-target area ion and photon synchronous radiotherapy system.

[0022] Figure 2 This is a reference diagram showing sensitive and drug-resistant tumor target areas.

[0023] The attached reference numerals include: rotating seat 1, ion therapy module 2, photon therapy module 3, online real-time imaging module 4, X-ray emitting device 41, flat panel detector 42, isolation block 5, controller 6, treatment plan module 7, and tumor multi-target generation module 8. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of the embodiments clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only for explaining the present invention and are not intended to limit the present invention.

[0025] Example 1 This embodiment is basically as shown in the appendix. Figure 1 As shown, a multi-target area ion and photon synchronous radiotherapy system includes a rotating seat 1, an ion therapy module 2, a photon therapy module 3, an online real-time imaging module 4, a controller 6, and a treatment plan module 7.

[0026] In this embodiment, the rotating seat 1 is fixedly installed and can rotate 360 ​​degrees around its axis. A human body can rotate evenly 360 degrees on the rotating seat 1, and the rotating seat 1 can be appropriately raised and lowered to adjust the height and posture of the human body. The rotating seat 1 is equipped with a motor as its power source to ensure that it can drive the human body to rotate evenly under its own power. The specific structure of the rotating seat 1 can adopt existing chairs with automatic rotation and lifting functions.

[0027] The ion therapy module 2 of the embodiment is fixedly arranged towards the rotating chair 1, and can be fixedly installed on a wall of a treatment room, so that the ion therapy module 2 remains stable. When a human body is located on the rotating chair 1, the ion therapy module 2 outputs an ion beam to perform targeted treatment on a drug-resistant tumor target area in the human body. The ion therapy module 2 can be a proton therapy device or a heavy ion therapy device in the prior art. The ion therapy module 2 performs tumor treatment by releasing an ion beam, and can further realize precise treatment of maximizing LET / RBE of the drug-resistant tumor target area by adjusting a scanning position, a dose rate, and an output energy of the output ion beam.

[0028] The photon therapy module 3 of the embodiment is also arranged towards the rotating chair 1, and can be fixedly installed on a wall of a treatment room, so that the photon therapy module 3 remains stable. When a human body is located on the rotating chair 1, the photon therapy module 3 is used to perform targeted treatment on a sensitive tumor target area in the human body. The photon therapy module 3 is a photon therapy device in the prior art, which performs tumor radiotherapy by emitting a photon beam. The photon therapy device can also precisely act on the sensitive tumor target area by adjusting a dose rate of the output photon and adjusting a position of a grating, so as to realize precise treatment of the sensitive tumor target area.

[0029] In order to reduce radiation, the embodiment can be provided with an isolation block 5 on the wall facing the photon therapy module 3. The isolation block can be a lead block, which plays a role of isolation and blocking through the lead block.

[0030] In order to reduce interference between the photon therapy module 3 and the ion therapy module 2, the photon therapy module 3 and the ion therapy module 2 are arranged at an included angle in the embodiment, and the included angle between the photon therapy module 3 and the ion therapy module 2 is preferably 90 degrees, at which the interference is smaller. Of course, in some embodiments, the included angle between the photon therapy module 3 and the ion therapy module 2 can also be other angles. However, the included angle between the photon therapy module 3 and the ion therapy module 2 cannot be 180 degrees, so as to avoid the photon therapy module 3 and the ion therapy module 2 from being opposite to each other.

[0031] In order to obtain the three-dimensional image of the tumor, so as to facilitate the monitoring of the tumor target position and the adjustment of the seat position, the online real-time image module 4 is arranged on the rotating seat 1. The online real-time image module 4 can be fixedly installed on the wall of the treatment room. The online real-time image module 4 comprises an X-ray emitting device 41 and a flat panel detector 42, and the X-ray emitting device 41 and the flat panel detector 42 are oppositely arranged, and the rotating seat 1 is located between the X-ray emitting device 41 and the flat panel detector 42. The X-ray emitting device 41 can be a CT module unit or a CBCT module unit. The three-dimensional image of the human body on the rotating seat 1 is obtained through the online real-time image module 4, so as to facilitate the monitoring of the tumor target position and the adjustment of the seat position.

[0032] In the embodiment, the online real-time image module 4 can be provided with one or two, but it is more preferred that the online real-time image module 4 is provided with two, and the three-dimensional image of the tumor is obtained by cooperation of the two online real-time image modules 4. The two online real-time image modules 4 are arranged at an included angle, and it is preferred that the included angle is 90 degrees. The two online real-time image modules 4 cannot be oppositely arranged.

[0033] In the embodiment, the online real-time image module 4, the rotating seat 1, the photon treatment module 3 and the ion treatment module 2 are signal-connected with the controller 6. The three-dimensional image of the tumor is fed back to the controller 6 by the online real-time image module 4, the controller 6 monitors the tumor target position and controls the adjustment of the seat state according to the three-dimensional image of the tumor; the rotating seat 1 can be uniformly rotated at different speeds under the control of the controller 6, and the height and posture of the rotating seat 1 can be adjusted; the photon treatment module 3 adjusts the output photon dose rate and adjusts the position of the grating under the control of the controller 6, so as to realize the accurate treatment of the sensitive tumor target; the ion treatment module 2 adjusts the output ion dose rate and adjusts the output energy under the control of the controller 6, so as to realize the accurate treatment of the drug-resistant tumor target. The controller 6 can be a medical equipment main controller used in the prior art, and only needs to increase the control and adjustment of the online real-time image.

[0034] Since the treatment control schemes required by different tumors are different, the treatment scheme planning module 7 is signal-connected with the controller 6 in the embodiment. The treatment scheme planning module 7 is used to determine the targeted treatment optimization control scheme according to different tumor states, and feed back the treatment control scheme to the controller 6, and the controller 6 controls the working state of the rotating seat 1, the photon treatment module 3 and the ion treatment module 2 according to the treatment control scheme, so as to realize the targeted tumor treatment. The treatment scheme planning module 7 is specifically a computer, which formulates the targeted treatment control scheme and feeds back the treatment control scheme to the controller 6.

[0035] The following detailed description of the specific implementation method is as follows: Before tumor treatment, the treatment plan module 7 formulates a corresponding treatment optimization control plan based on the tumor status and feeds back the corresponding treatment control plan to the controller 6.

[0036] Next, the human body is positioned on the rotating seat 1, which rotates the body evenly. During this rotation, the online real-time imaging module 4 acquires three-dimensional images of the tumor within the body and adjusts the posture of the human body and the rotating seat 1 based on these images to ensure precise treatment. Once the postures of the human body and the rotating seat 1 are adjusted, tumor treatment can begin.

[0037] During tumor treatment, the controller 6, based on the obtained treatment control plan, controls the rotating seat 1 to rotate the body uniformly at a predetermined speed. During this rotation, the controller 6 coordinates the ion therapy module 2 and the photon therapy module 3 to target sensitive and drug-resistant tumor target areas within the tumor cells, thereby achieving better treatment results. Throughout the treatment process, the online real-time imaging module 4 continuously monitors the tumor target area position; if any unexpected events occur, the treatment is immediately stopped.

[0038] Example 2 This embodiment is an improvement on embodiment 1, such as... Figure 1 As shown, in order to distinguish between sensitive tumor target areas and drug-resistant tumor target areas in a tumor, this embodiment sets up a tumor multi-target area generation module 8 and a treatment plan planning module 7 with signal connection. The tumor multi-target area generation module 8 detects the tumor target area information of tumor cells and feeds back the obtained information to the treatment plan planning module 7. The treatment plan planning module 7 determines a targeted treatment control plan based on the obtained data.

[0039] The tumor multi-target generation module 8 in this embodiment specifically includes an organ imaging unit, a molecular imaging unit, and a processor. The organ imaging unit, the molecular imaging unit, and the processor are connected by signals.

[0040] In the process of distinguishing the tumor target area, the position information of the tumor in the human body is obtained by the organ imaging device, and the spatial density distribution information of the tumor cells is obtained by the molecular imaging unit. The spatial density distribution information of the tumor cells is obtained indirectly by measuring the data such as tumor cell metabolic activity, fibrosis expression, and specific antibody. The images for obtaining the above data include tumor cell metabolism image, tumor fibrosis image, and tumor cell specific antibody image. When the molecular imaging unit obtains the spatial density distribution information, the spatial density distribution information of the tumor cells before treatment and the spatial density distribution information of the tumor cells after a predetermined dose of treatment (such as 2Gy of standard dose of radiotherapy) need to be obtained. Then, the organ imaging unit and the molecular imaging unit feed back the obtained information to the processor, and the processor processes the data by algorithm and model to generate a tumor drug sensitivity distribution map, which can be specifically referred to as shown in Figure 2 According to the tumor drug sensitivity distribution map and the spatial density distribution information of the tumor cells before treatment, the target area information of the drug-resistant tumor target area and the sensitive tumor target area is obtained.

[0041] Example 3 This embodiment is improved on the basis of example 1. In the scheme of example 1, the rotating seat 1, the ion treatment module 2, the photon treatment module 3 and the online real-time imaging module 4 are installed on the wall of the treatment room. Obviously, due to the different positions of the wall, the installation state needs to be adjusted correspondingly in different environments, which is relatively cumbersome. In order to install the rotating seat 1, the photon treatment module 3, the ion treatment module 2 and the online real-time imaging module 4, a treatment cabin is separately provided as the installation basis. The treatment cabin can be a cylindrical cabin body, and the treatment cabin is provided with a cabin door for personnel to enter. The rotating seat 1 can be specifically installed at the middle position of the treatment cabin, and the online real-time imaging module 4, the photon treatment module 3 and the ion treatment module 2 are installed on the side wall of the treatment cabin, so that the online real-time imaging module 4, the photon treatment module 3 and the ion treatment module 2 remain stable and fixed in position.

[0042] The above is only an embodiment of the present application, and the specific structure and characteristics of the scheme are not described in detail. It should be pointed out that for those skilled in the art, without departing from the structure of the present application, a number of modifications and improvements can be made, which should be regarded as the protection scope of the present application, and these will not affect the effect and practicality of the patent. The protection scope claimed in this application should be subject to the content of its claims, and the specific implementation mode and the like recorded in the specification can be used to explain the content of the claims.

Claims

1. A multi-target volume ion and photon synchronous radiotherapy system, characterized in that: The utility model provides a rotating chair (1) for driving human body rotation, ion therapy module (2) and photon therapy module (3) are arranged around rotating chair (1); The release end of ion therapy module (2) is arranged towards rotating chair (1), and ion therapy module (2) is used to output ion beam to drug resistance tumor target area, and ion beam inactivates drug resistance tumor target area;The release end of photon therapy module (3) is arranged towards rotating chair (1), and photon therapy module (3) is used to output photon beam to sensitive tumor target area, and photon beam inactivates sensitive tumor target area; Rotating chair (1), photon therapy module (3) and ion therapy module (2) are signal connected to controller (6) respectively, and treatment scheme planning module (7) is signal connected on controller (6).

2. The multi-target volume ion and photon synchronous radiotherapy system of claim 1, wherein: The scanning position, dose rate and output energy of the output end of ion therapy module (2) can be adjusted, so that the LET / RBE is adjusted and the ion beam is accurately acted on the drug resistance tumor target area.

3. The multi-target volume ion and photon synchronous radiotherapy system of claim 1, wherein: The grating position and metering rate of the output end of photon therapy module (3) can be adjusted, so that the photon beam is accurately acted on the sensitive tumor target area.

4. The multi-target volume ion and photon synchronous radiotherapy system of claim 1, wherein: It also includes an online real-time image module (4) arranged towards rotating chair (1), and the online real-time image module (4) is signal connected to controller (6); The online real-time image module (4) receives the control signal of controller (6), and the tumor target area position is monitored in real time;The online real-time image module (4) returns the monitoring data to controller (6), and controller (6) controls the working state change of rotating chair (1), ion therapy module (2) and photon therapy module (3).

5. The multi-target volume ion and photon synchronous radiotherapy system of claim 4, wherein: The online real-time image module (4) is provided as two, and the two online real-time image modules (4) are distributed at an included angle, and the two online real-time image modules (4) cooperate to realize real-time monitoring of tumor target area position.

6. The multi-target volume ion and photon synchronous radiotherapy system of claim 4, characterized in that: The online real-time image module (4) includes X-ray emitting device (41) and flat panel detector (42), and the X-ray emitting device (41) and flat panel detector (42) are oppositely arranged, and rotating chair (1) is located between the X-ray emitting device (41) and flat panel detector (42).

7. The multi-target volume ion and photon synchronous radiotherapy system of claim 6, characterized in that: The X-ray emitting device (41) is a CT module unit or a CBCT module unit.

8. The multi-target volume ion and photon synchronous radiotherapy system of claim 1, wherein: It also includes a tumor multi-target area generation module (8) connected with treatment scheme planning module (7), and the tumor multi-target area generation module (8) is used to obtain the information of tumor cells and send the information to treatment scheme planning module (7); And / or, it also includes a treatment cabin, and rotating chair (1) is arranged in the middle of treatment cabin, and photon therapy module (3) and ion therapy module (2) are fixedly installed on the side wall of treatment cabin.

9. The multi-target volume ion and photon synchronous radiotherapy system of claim 8, characterized in that: The tumor multi-target region generating module (8) comprises an organ image unit, a molecular image unit and a processor, the organ image unit is used to acquire the position information of the tumor in the human body, the molecular image unit is used to acquire the spatial density distribution information of the tumor cells, and the processor generates the tumor target region information by the information acquired by the organ image unit and the molecular image unit and sends the tumor target region information to the treatment plan module (7).

10. The multi-target volume ion and photon synchronous radiotherapy system of claim 9, wherein: The molecular image unit acquires the spatial density distribution information of the tumor cells before treatment and acquires the spatial density distribution information of the tumor cells after a predetermined dose of treatment.

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