Fluid valve for an analysis device

Abstract

A fluid valve for an analysis device is disclosed. Described is a valve (100), in particular for an analysis device (10) for analyzing a fluid sample, comprising: i) a stator element (110) having a stator boundary surface (111); and ii) a rotor element (120) having a rotor boundary surface (121); a) wherein the stator element (110) and the rotor element (120) are arranged in the axial direction (A); b) wherein the stator boundary surface (111) and the rotor boundary surface (121) are pressed against each other in the axial direction (A) by an axial force (P); and c) wherein the axial force (P) is fixed by a non-removable connection.

Description

Technical Field

[0001] This invention relates to a valve in an analytical apparatus for analyzing fluid samples, comprising a stator element and a rotor element. The stator element and rotor element are axially pressed against each other by an axial force, and the axial force is fixed in at least one direction of action by a non-removable connection (e.g., press fit). The invention also relates to an analytical apparatus including the valve and a method for manufacturing such a valve. Background Technology

[0002] Provide analytical devices, such as sample separation devices, for analyzing samples, especially fluid samples, for example for chromatographic separation of samples.

[0003] For example, in an HPLC (high performance liquid chromatography) analytical apparatus, a liquid (mobile phase) moves at a very precisely controlled flow rate (e.g., in the range of microliters to milliliters per minute) and high pressure (typically 20 to over 1000 bar, currently up to 2000 bar), at which the compressibility of the liquid can be readily observed through a so-called stationary phase (e.g., in a chromatographic column) to separate the individual fractions of the sample liquid introduced into the mobile phase from each other. After passing through the stationary phase, the separated fractions of the fluid sample are detected in a detector. Such an HPLC system is known, for example, from EP 0,309,596 B1 of the same applicant, Agilent Technologies.

[0004] Fluid valves used in analytical apparatus (particularly HPLC) are, for example, check valves, wippventile valves, or rotary valves, the latter comprising a stator and a rotor. The stator is typically a stationary component, for example, cylindrical in shape, having a first side (interface side) with capillary connections and an opposing (planar) second side (port side) (stator boundary surface) with cylindrical channel openings or grooves. In this case, the first side faces and connects to a fluid source (e.g., solvent supply), while the second side is connected to the analytical domain of the apparatus (e.g., sample separation column) via the rotor. The rotor is typically provided as a rotating disk between the stator and the analytical domain of the apparatus. The rotor (with a planar surface) (rotor boundary surface) presses against the (planar) port side with the channel openings of the stator. By rotating the rotor relative to the stator, the individual channels can now be opened and closed based on their respective geometries.

[0005] The boundary surfaces of the rotor and stator must press against each other axially (e.g., two planes pressing against each other) to achieve the necessary seal for the fluid. The pressure should be adjusted to a value that provides a sufficient seal, but it should not be too high, as this could otherwise interfere with fluid flow or damage components.

[0006] In traditional solutions, axial pressure is achieved through spring force, which is adjusted by an adjusting screw or shims. However, a drawback of the adjusting screw is that the force can be subsequently changed by tightening, potentially making the desired force irreversible. Another problem with known solutions is that the alignment of the adjusting screw depends on the thread, which typically includes large tolerances. This also means that the bushings of the bearings acting as the shaft are not properly aligned on the valve axis. This often leads to problems with the valve's lifespan and functionality. Furthermore, the aforementioned shims can result in repetitive manufacturing processes, which are very time-consuming and therefore also disadvantageous. Summary of the Invention

[0007] There may be a need to provide an efficient, robust, and reliable valve for the analytical apparatus. This problem is addressed by the independent claims. Further exemplary embodiments are shown in the dependent claims.

[0008] According to a first exemplary embodiment of the present invention, a (fluid) valve (e.g., a rotary valve), particularly for an analytical apparatus (e.g., HPLC) for analyzing fluid samples, is described. The valve includes:

[0009] i) stator elements having stator boundary surfaces (port side, opposite to interface side) and ii) rotor elements having rotor boundary surfaces (port side, opposite to the interface of the analysis system).

[0010] The stator and rotor elements are arranged axially (the valve's axial direction, the main extension direction, the preferred direction), wherein the stator boundary surfaces and the rotor boundary surfaces are pressed together axially by axial forces (particularly axially acting pressure). In particular, the axial forces (in at least one direction of action, particularly in two (opposite) directions of action) are secured by a non-removable connection.

[0011] According to a second exemplary embodiment of the present invention, an analytical apparatus is described, which includes at least one valve as described above.

[0012] According to a third exemplary embodiment of the present invention, a method for manufacturing a valve (e.g., as described above) comprising a stator element and a rotor element pressed together axially by an axial force is described, the method comprising: i) adjusting the axial force, and ii) fixing the axial force by a non-detachable connection (in at least one direction of action).

[0013] In the context of this article, the term "non-removable connection" may specifically refer to a connection that cannot be disassembled in a non-destructive manner. An illustrative example of a non-removable connection may be a press fit (or a cylindrical press-fit assembly). In this case, an element is pressed into an opening (e.g., a push-button element or stator element in a valve body) such that the element cannot be removed without damaging the opening or at least a portion of the element. While push-out is possible in principle, it is not considered a non-destructive disassembly in this context. Another example of a non-removable connection may be a material connection. For example, an element may be glued, brazed, or welded into an opening in a valve body. In one example, the non-removable connection does not have removable connecting elements, such as screws.

[0014] In the context of this document, the term "axial force fixed" may specifically refer to the fact that a force acting along (parallel to) the valve axis (particularly defined by the rotor shaft) is set and maintained at a specific pressure. Preferably, a non-removable connection is used to fix the axial force (used to press the rotor and stator together) at a specific / desired value. This can be achieved, for example, by pre-tensioning a spring to a specific value and then non-removably fixing it in that position.

[0015] In the context of this document, the term "fixed in at least one (acting) direction" can refer to an axial force that is irremovably fixed in at least one direction, while being at least temporarily removable in the other opposite direction. The axial force acts along the valve axis and thus has two directions. Schematably, the axial force can be achieved by a spring force, wherein the spring can expand in both (opposite) directions. According to the invention, expansion in at least one of these directions can be blocked by a non-removable connection (e.g., a press-fit sleeve). In one exemplary embodiment of the invention, the axial force can be fixed in opposite directions (relative to the non-removable connection) by a removable connection (e.g., a stator element). However, in another exemplary embodiment of the invention, the axial force can also be fixed in two opposite directions by a non-removable connection, for example, if the stator element is used as a press-fit element.

[0016] In the context of this document, the term "stator element" may specifically refer to the stator or a portion thereof of an analytical apparatus. A stator element can be a component that does not move, particularly during operation, i.e., a component arranged in a static manner. The stator element may be constructed in a cylindrical or similar manner and includes two opposing sides. A first side may be connected to one or more fluid supply sources, while the opposing second side may be coupled to a rotor element and is preferably constructed in a planar manner for this purpose. Thus, the stator element can be used to supply one or more fluids, while the rotor element can switch between different operating modes.

[0017] In the context of this document, the term "rotor element" may specifically refer to the rotor of an analytical apparatus or a portion thereof. A rotor element can be a component that moves particularly during operation, i.e., a component arranged in a rotatable manner (relative to the stator element). The rotor element may also be constructed in a cylindrical or similar manner (particularly in a disc-like manner), wherein the sides in contact with the stator element are preferably constructed in a planar manner. The rotor element can be switched (similar to switching positions) by rotating between different fluid paths, wherein fluid is supplied by the stator element and, in particular (after mixing / proportioning), is also discharged again through the stator element.

[0018] In the context of this article, the term “fluid” specifically refers to liquids and / or gases, and optionally includes solid particles.

[0019] In the context of this article, the term "fluid sample" specifically refers to a medium containing the actual substance to be analyzed (e.g., a biological sample), and more particularly liquids such as protein solutions, drug samples, etc.

[0020] In the context of this document, the term "mobile phase" specifically refers to a fluid, and more particularly a liquid, which serves as a carrier medium for transporting fluid samples between a fluid drive and a sample separation unit. However, a mobile phase can also be used in fluid delivery devices to influence the fluid sample. For example, a mobile phase can be a solvent (e.g., organic and / or inorganic) or a combination of solvents (e.g., water and ethanol).

[0021] In the context of this document, the term "analytical apparatus" may specifically refer to an apparatus capable of and constructed for examining fluid samples, particularly separating fluid samples, and even more particularly separating them into different fractions. Such sample separation can be performed, for example, by chromatography or electrophoresis. Preferably, the analytical apparatus may be a liquid chromatography sample separation apparatus.

[0022] According to an exemplary embodiment, the present invention can be based on the concept that if axial forces (for pressing the rotor and stator elements together) are fixed in at least one direction by a non-removable connection (or cannot be disassembled in a non-destructive manner), an efficient, robust, and reliable valve can be provided for the analytical apparatus. Because the press sleeve is pressed into the valve body, this non-removable connection can be achieved, for example, in a simple manner by press fitting.

[0023] Traditionally, this axial force (pressure) is fixed by a detachable connector (e.g., an adjusting screw). However, according to the invention, a completely different approach is now chosen: the axial force is fixed in a non-detachable manner (in at least one direction). This method ensures that the same precise axial force (e.g., spring force) is always present, even over long periods. Advantageously, it is impossible to accidentally or unintentionally adjust the axial force as in the case of an adjusting screw. Furthermore, manufacturability can be improved in terms of complexity and speed, particularly in terms of automated manufacturability. This is especially true because rotating the adjusting screw is no longer necessary; only pressure is used (e.g., by installing a press). In other words, measurement and pressing can be performed efficiently and quickly, particularly in an automated manner. Another advantage is that the press-fit element (e.g., a press-fit sleeve) can be precisely aligned to provide a non-detachable connection. Accordingly, the rotor shaft and / or rotor seals can be guided more efficiently.

[0024] The axial force required to seal the valve (e.g., implemented as a spring preload) can be achieved by controlling the force path of, for example, the pressing element or the stator element. Because the corresponding valve according to the invention can be designed for the service life of a device (e.g., an analytical device), maintenance is no longer required (essentially).

[0025] In one exemplary embodiment, the force regulated during production cannot be subsequently changed by the user / customer. Furthermore, in one example, the valve cannot be opened for maintenance, which is also undesirable because the valve can only be manufactured under production conditions using suitable tools to ensure its service life. In another example (where the stator is not pressed in), maintenance is still possible, but limited to the regulated pressure. The described technical solution requires fewer parts, is simpler to produce, and is therefore more cost-effective. It also advantageously ensures that the force regulation will not be changed later.

[0026] Exemplary embodiments

[0027] According to exemplary embodiments, the non-removable connection includes at least one of the following features: form-fit connection (particularly press-fit connection), material connection (particularly adhesive connection), welded connection, and brazed connection. In a preferred exemplary embodiment, the non-removable connection is provided by press-fit (German: Presssitz). In this case, an element (e.g., a pressing element such as a sleeve, or the stator element itself) can be pressed into the valve body in a manner that makes non-destructive removal impossible. This pressing can be implemented by pressure (via a pressing device such as a press). In one example, the diameter of the pressed-in element can be at least partially larger than the opening through which the element is pressed in.

[0028] In the illustrative example, the axial force can be achieved using a spring, which is pre-tensioned to a specific point and then fixed. If the fixing is done via a press fit, this can be called a non-removable connection.

[0029] According to an exemplary embodiment, the non-removable connection does not have removable connecting elements, particularly screws. Compared to conventional methods such as adjusting screws, the present invention provides non-removable axial force fixation in a targeted manner.

[0030] According to an exemplary embodiment, the axial force includes a spring force. This allows for simple and reliable implementation using proven components such as (leaf) springs. According to an exemplary embodiment, the axial force is fixed to a predetermined (desired) value. This has the advantage that the desired value of the axial force is fixed and does not change or can be changed. Therefore, a longer service life and reliable operation can be ensured.

[0031] According to an exemplary embodiment, the valve is configured as a rotary valve, particularly a rotary shear valve. According to an exemplary embodiment, the valve is configured as a high-pressure valve. According to an exemplary embodiment, the valve is configured as a fluid valve, particularly a fluid switching valve. According to an exemplary embodiment, axial force closes the valve in a fluid-tight manner. These features may have the advantage that this disclosure can be directly implemented in economically / technically important applications.

[0032] According to an exemplary embodiment, the valve includes a rotor shaft coupled to a rotor element. Specifically, the rotor shaft is coupled / connected to a wider (disc-shaped, flange-shaped) rotor assembly. In the example, the rotor assembly (or rotor shaft) includes a drive element (e.g., a drive pin) to rotate the rotor element. The rotor shaft may be driven by a drive device (e.g., an electric motor). According to an exemplary embodiment, the rotor shaft is configured to enable the rotor element to rotate. According to an exemplary embodiment, the rotor shaft is arranged axially (or defines an axial direction). In this way, effective rotation can be achieved even under high contact pressure on the stator element.

[0033] According to an exemplary embodiment, the valve includes at least one resilient element. According to an exemplary embodiment, the resilient element is arranged axially. According to an exemplary embodiment, the resilient element is configured to provide at least a portion of the axial force. This can have the advantage that the adjustable (and fixable) axial force can be implemented directly and simply using proven techniques.

[0034] According to an exemplary embodiment, the elastic element is configured as a spring, particularly a leaf spring. According to an exemplary embodiment, the elastic element is configured as a cylinder. According to an exemplary embodiment, the elastic element is arranged around a rotor shaft, particularly in a cylindrical arrangement. According to an exemplary embodiment, the elastic element is configured as a radial bearing. One or more of these features enable the elastic element to be implemented efficiently and reliably. For example, the configuration as a spring arranged cylindrically around a rotor shaft can be particularly space-saving while providing protection and stability.

[0035] According to an exemplary embodiment, the valve includes a pressing element, particularly a pressing sleeve. According to an exemplary embodiment, the pressing element is axially fixed by a non-removable connection, particularly a press-fit connection.

[0036] According to an exemplary embodiment, the pressing element is configured as a cylinder. According to an exemplary embodiment, the pressing element is arranged around the rotor shaft, particularly in a cylindrical arrangement. According to an exemplary embodiment, an elastic element is arranged between the pressing element and the rotor element. The advantage of these configurations is that the pressing element can be arranged in a space-saving and / or centered manner, while ensuring effective movement of the rotor shaft.

[0037] According to an exemplary embodiment, the valve includes a blocking element arranged axially and configured to block the expansion of the resilient element in one direction. The blocking element is particularly useful in exemplary embodiments where the stator element is pressed into the valve body. In this case, the resilient element is displaced by stator-side pressure. However, the blocking element can easily prevent such yielding, thereby pre-tensioning the resilient element.

[0038] According to an exemplary embodiment, the blocking element is constructed as part of the valve body (or housing). This can be a simple and robust implementation. According to an exemplary embodiment, the blocking element is arranged around the rotor shaft, particularly in a cylindrical shape. As a result, space can be saved while the movement of the rotor shaft remains undisturbed. According to an exemplary embodiment, a resilient element is arranged between the blocking element and the rotor element (or rotor assembly).

[0039] According to an exemplary embodiment, the valve includes: an axial bearing, specifically arranged between a pressing element (or blocking element) and a resilient element. According to an exemplary embodiment, the valve includes: a radial bearing, specifically arranged between the resilient element and a rotor element. In the example, the radial bearing is configured as a ball bearing or a sliding bearing. This can have the advantage of achieving efficient force distribution and operating modes through proven and established techniques.

[0040] According to an exemplary embodiment, the valve includes a valve body, in which at least a portion of a rotor element and a stator element are arranged. In this context, the term "valve body" may specifically refer to at least a portion of the valve in which the rotor element (and rotor shaft), a resilient element, and (at least partially) the stator element are arranged. Thus, the valve body can be considered as a housing in which these components are arranged. In the example, a blocking element may be configured as part of this housing. In the example, the valve body is at least partially cylindrical. In the example, the valve body includes a front (stator-side) opening and / or an opposing (rotor-side) opening, the latter of which can be coupled to a drive mechanism. In the example, the stator element is pressed in from the stator side. In the example, the pressing element is pressed in from the rotor side.

[0041] According to an exemplary embodiment, the stator element is fastened to the valve body, particularly by a detachable connector, and more particularly by a screw connector. In the example, the stator element can be detachable or replaceable, regardless of the non-removable fixed axial force. For this embodiment, it is preferred that the stator element be detachably fastened to the valve body / housing, for example by a magnet, screwing, tightening, or by fastening elements. This can have the advantage that the stator element can be handled and maintained flexibly. Furthermore, the stator element can also be arranged on the valve only after the axial force has been adjusted and fixed (e.g., in a dummy structure, see...). Figure 3A and 3B When the stator element is removed, the axial force will indeed be released in this direction. However, by retightening the stator element, the axial force will be restored.

[0042] According to an exemplary embodiment, the stator element is fixed in the valve body by a press-fit connection. In this exemplary embodiment (for example, see...), Figures 6A to 6C Instead of a pressing element, a stop element is pressed into the stator element itself to provide a non-removable connection. In this example, the stator element cannot be removed non-destructively after being pressed in. The stop element ensures that the desired axial force can be adjusted.

[0043] According to an exemplary embodiment, a combination of a pressing element and a pressed-in stator element is also possible. Therefore, for example, two opposite sides can be pressed into the valve body.

[0044] According to an exemplary embodiment, the valve has no adjusting mechanism, specifically no adjusting screw. According to an exemplary embodiment, the valve is configured to operate in a maintenance-free manner. According to an exemplary embodiment, the adjusting axial force in the valve cannot be changed (in a non-destructive manner). As mentioned above, a non-removable, fixed axial force can have several advantages. In particular, high reliability can be ensured over a long service life, where virtually no maintenance is required.

[0045] According to an exemplary embodiment, the stator or rotor elements are replaceable. Therefore, more flexible operation can be achieved. According to an exemplary embodiment, the stator and / or rotor elements include at least one of the following materials: metal, particularly stainless steel, ceramic, and plastic. Therefore, efficient production methods can be implemented using proven and established materials.

[0046] According to an exemplary embodiment, the method includes: pre-installing at least one elastic element in a valve body and pressing a pressing element into the valve body to adjust the axial force via the elastic element and fix the adjusted axial force while providing a non-removable connection. According to an exemplary embodiment, the axial force is measured or monitored during pressing. The advantage of this is that it allows for highly efficient automation: the axial force and pressing can be adjusted simultaneously, and the pressing process can be stopped once the desired force is reached.

[0047] According to an exemplary embodiment, the method includes: pre-installing at least one elastic element in a valve body, preventing the elastic element (e.g., by a blocking element) from expanding in one direction (particularly the rotor side of the valve body), and pressing a stator element into the valve body so as to adjust the axial force by the elastic element abutting against the blocking element, and to fix the adjusted axial force while providing a non-removable connection. The advantage of this approach is that it enables highly efficient automation: the axial force and pressing can be adjusted simultaneously, and the pressing process can be stopped once the desired force is reached.

[0048] According to an exemplary embodiment, the method includes applying a dummy structure (mounting element) at the position of the rotor element and / or the stator element during axial force adjustment, which is specifically configured to measure the axial force. Preferably, such a dummy structure may include or be coupled to a measuring device. The advantage of this is that it allows for highly efficient automation: the axial force and pressing can be adjusted simultaneously, and the pressing process can be stopped once the desired force is reached.

[0049] According to an exemplary embodiment, the analytical apparatus is configured as a sample separation device. According to an exemplary embodiment, the analytical apparatus includes a fluid actuator for driving a mobile phase and injecting a fluid sample into the mobile phase. According to an exemplary embodiment, the analytical apparatus includes a sample separation unit for separating the fluid sample injected into the mobile phase. According to an exemplary embodiment, the analytical apparatus is configured to analyze at least one physical, chemical, and / or biological parameter of a fluid sample. According to an exemplary embodiment, the analytical apparatus is configured as a sample separation device for separating fluid samples.

[0050] In the context of this application, the term "sample separation unit" may specifically refer to a unit used for analyzing fluid samples, particularly a unit for separating them into different fractions. For this purpose, components of the fluid sample may first be adsorbed onto the sample separation unit and then desorbed individually (particularly as fractions). For example, such a sample separation unit may be constructed as a chromatographic separation column.

[0051] According to an exemplary embodiment, the analytical apparatus is a chromatographic apparatus, particularly a liquid chromatographic apparatus, a gas chromatographic apparatus, an SFC (supercritical liquid chromatography) apparatus, or an HPLC (high performance liquid chromatography) apparatus.

[0052] According to an exemplary embodiment, the analytical device is configured as a microfluidic device. According to an exemplary embodiment, the analytical device is configured as a nanofluidic device.

[0053] According to an exemplary embodiment, the sample separation unit is configured as a chromatographic separation unit, particularly a chromatographic separation column.

[0054] According to an exemplary embodiment, the fluid actuator is configured to drive the mobile phase and the fluid sample under high pressure.

[0055] According to an exemplary embodiment, the fluid actuator is configured to drive the mobile phase and the fluid sample at a pressure of at least 500 bar, particularly at least 1000 bar, further particularly at least 1200 bar, and even more specifically at least 1500 bar.

[0056] According to an exemplary embodiment, the analytical apparatus includes a detector for detecting fluid samples that have been analyzed, particularly those that have been separated.

[0057] According to an exemplary embodiment, the analytical apparatus includes a distiller for distilling a separated fraction of a fluid sample.

[0058] The analytical apparatus can be a microfluidic measurement device, a life science device, a liquid chromatography device, a gas chromatography device, an HPLC (high performance liquid chromatography), a UHPLC device, or a SFC (supercritical liquid chromatography) device. However, many other applications are also possible.

[0059] According to an exemplary embodiment, the sample separation unit can be configured as a chromatographic separation unit, particularly a chromatographic separation column. In chromatographic separation, the chromatographic separation column can be provided with an adsorption medium. The fluid sample can be stopped here and can only be desorbed stepwise again in the presence of a specific solvent composition, thereby separating the sample into its fractions.

[0060] Pumping systems used for conveying fluids can be configured to, for example, convey fluids or mobile phases through the system at high pressures, such as from several hundred bar to 1,000 bar or even higher.

[0061] The analytical apparatus may include a sample injector for introducing a sample into a fluid separation path. Such a sample injector may include a sample or injection needle that can be coupled to a needle hub in a corresponding liquid path, wherein the sample needle can be removed from the needle hub to receive the sample. After the sample needle is reinserted into the needle hub, the sample may be located in a fluid path that can be switched, for example, to the system's separation path via a switching valve. In another exemplary embodiment of the invention, the sample injector or sampler may be used with a sample needle that operates without a needle hub.

[0062] The analytical apparatus may include a fraction collector for collecting the separated components. For example, such a fraction collector can direct different components of the separated sample into different liquid containers. However, the analyzed sample may also be supplied to a discharge container.

[0063] Preferably, the analytical apparatus may include a detector for detecting the separated components. This detector can generate a signal that can be observed and / or recorded and indicates the presence and quantity of the sample components in the fluid flowing through the system.

[0064] In an exemplary embodiment, a precise valve force setting with a pressing sleeve is described for accurately limiting the spring force. During installation, the entire valve, without the sleeve and stator pressed in, is placed on an installation tool (dummy structure). Now, using an installation press, the desired spring force is applied to the axial bearing, and the position is recorded. The next step involves pressing the sleeve in the valve body into the storage position. Finally, the rotor and stator must be installed in / on / in the valve body.

[0065] In an exemplary embodiment, it is described that the axial force (on the rotor) is measured during stator pressing to set a specific axial force. However, this is also possible without measuring the actual axial force, for example, by using a known value. Attached Figure Description

[0066] Other objects and numerous incidental advantages of the embodiments of the present invention will become apparent and will be better understood by referring to the following more detailed description of the embodiments in conjunction with the accompanying drawings. Features that are substantially or functionally identical or similar are denoted by the same reference numerals.

[0067] Figure 1 An analytical apparatus including a valve is shown according to an exemplary embodiment of the present invention.

[0068] Figure 2 An external view of a valve according to an exemplary embodiment of the present invention is shown.

[0069] Figure 3A and 3B An exemplary embodiment of the invention is shown, which describes adjusting the axial force in a valve by pressing in a pressing element.

[0070] Figure 4 A cross-section of a valve according to an exemplary embodiment of the present invention is shown.

[0071] Figure 5 Another example of a valve according to an exemplary embodiment of the present invention is shown.

[0072] Figures 6A to 6C An exemplary embodiment of the invention is shown, which describes the adjustment of axial force in a valve by pressing in a stator element. Detailed Implementation

[0073] The illustrations in the attached diagram are schematic.

[0074] Figure 1 The basic structure of an HPLC system is shown as an example of an analytical apparatus 10 configured as a sample separation device according to an exemplary embodiment of the present invention, which can be used, for example, in liquid chromatography. A fluid delivery device or fluid driver 20, supplying solvent from a supply unit 25, drives the mobile phase through a sample separation unit 30 (e.g., a chromatographic column) containing a stationary phase. The supply unit 25 includes a first fluid component source for providing a first fluid or a first solvent component A (e.g., water) and a second fluid component source for providing another second fluid or a second solvent component B (e.g., an organic solvent). An optional degasser 27 can degas the solvent supplied by the first and second fluid component sources before the solvent is supplied to the fluid driver 20. Optionally, the solvents can be mixed at a mixing point.

[0075] A sample supply unit (also represented as a syringe 40) is arranged between the fluid actuator 20 and the sample separation unit 30 to first receive a liquid or fluid sample from the sample container into a sample receiving volume in the syringe path, and then introduce it into the fluid separation path between the fluid actuator and the sample separation unit 30 by switching the injection valve of the syringe 40. Receiving the fluid sample from the sample container can be specifically performed by removing the sample needle from the sample holder and moving it into the sample container, drawing the fluid sample from the sample container into the sample receiving volume through the sample needle via a fluid delivery device configured as a metering unit, and then moving the sample needle back into the needle holder.

[0076] A stationary phase is provided in sample separation unit 30 for separating the components of the sample. A detector 50 (which may include a flow cell) detects the separated components of the sample. A distillation apparatus or fractionator 60 may be provided for discharging the separated components of the sample into a provided container. Unused liquid may be discharged into a discharge container or waste line.

[0077] When the liquid path between the fluid driver 20 and the sample separation unit 30 is normally under high pressure, the sample liquid is first introduced at atmospheric pressure into the area of ​​the sample supply unit or syringe 40 separated from the liquid path, i.e., the sample loop or sample receiving volume. Subsequently, the sample liquid is introduced into the separation path under high pressure. The sample loop, which is the sample receiving volume, can represent part of a fluid pipeline configured to receive or temporarily store a predetermined amount of fluid sample. Preferably, even before the sample liquid initially at atmospheric pressure in the sample receiving volume is switched to the separation path under high pressure, the contents of the sample receiving volume are raised to the system pressure of the analytical apparatus 10, configured as an HPLC, by a pressurizing device (e.g., a metering unit or pump) in the form of a fluid delivery device. The control unit 70 controls the various components 20, 25, 30, 40, 50, 60, etc., of the analytical apparatus 10.

[0078] Figure 1 A valve 100 (see detailed description below) is also shown, through which fluids (e.g., different solvents), fluid samples, salt solutions, or dispersions can be mixed with each other. The valve 100 can be arranged, for example, upstream (for solvent mixing) and / or downstream (for solvent and fluid sample mixing) of a fluid actuator 20.

[0079] Figure 2 An external view of a valve 100 according to an exemplary embodiment of the present invention is shown. A block-shaped portion of the housing can be seen, in which a drive device, such as an electric motor, is arranged. The electric motor drives a rotor shaft 130, which extends through the valve body 140 and rotates the rotor element 120 (in...). Figure 2 (The rotor element 120 is located within the housing or valve body 140 and is not visible). On the right-hand side, the valve 100 includes a cylindrical portion of the housing in which the rotor element 120 is arranged. A portion of the stator element 110 is visible at the right-hand end, i.e., the exposed interface side, to which fluid lines (e.g., capillaries) can be connected.

[0080] Figure 3A and 3B The diagram illustrates the axial force P (axial pressure pressing the stator and rotor elements together) in a valve 100 according to an exemplary embodiment of the invention. The valve body 140 of the valve 100 is shown in both figures (see Figure 140). Figure 2The rotor shaft 130 extends through the valve body. The rotor shaft 130 is connected to the rotor element 120 via a common rotor assembly 131 and a drive pin (rotor pin) 132, such that rotation of the rotor shaft 130 under the action of a drive device enables rotation of the rotor assembly 131 and the rotor element 120 connected thereto. The rotor shaft 130 is arranged along the axial direction A of the valve 100 or defines the valve 100.

[0081] Valve 100 includes an elastic element 150 arranged along an axial direction A, which can provide or adjust an axial force P. In the example shown, the elastic element 150 is configured as a cylindrical leaf spring 151. The elastic element 150 is arranged cylindrically around a rotor shaft 130. Furthermore, an axial bearing 152 and a radial bearing 153 (e.g., a ball bearing or a sliding bearing) are also provided in the valve body 140. In the example shown, the elastic element 151 (leaf spring) is arranged between the radial bearing 153 (which is adjacent to the rotor assembly 131) and the axial bearing 152. All these elements are arranged cylindrically around the rotor shaft 130.

[0082] The rotor shaft 130 represents the force acting on the rotor element 120 along the axial direction A as an axial force P. To set the axial force P to a desired value, a measuring device 181 is used. In the example shown, instead of the stator element 110 and rotor element 120, a dummy structure 180 (or mounting structure) is provided that closes the opening of the valve body 140 (which would otherwise close the stator element 110). However, compared to the stator element 110, the dummy structure 180 is coupled to the measuring device 181, allowing the measurement of the axial force P, which causes the rotor assembly 131 to press against the dummy structure 180 axially (before the rotor element 120 is inserted) (or against the stator element 110). A portion of the applied pressure is transmitted directly from the pressing element 160 to the valve body 140 via a cylindrical press fit. The remaining portion of the pressure corresponds to the axial force P.

[0083] Figure 3A Pressure is applied along the axial direction A to the elastic element 150 via a pressing device (e.g., a mounting / servo press), not shown. In this example, leaf springs 151 arranged between axial bearing 152 and radial bearing 153 are pressed together. The rotor assembly 131 presses against the dummy structure 180 via the elastic element 150 under pressure. This pressure, or axial force P, can be measured and monitored by a measuring device 181. The pressing device can be stopped when the desired axial force P is applied (at the dummy structure 180). Furthermore, the position of the pressing device under the desired pressure is stored.

[0084] Figure 3B :exist Figure 3AIn this process, the desired axial force P has been set by pre-tensioning the elastic element 150 in a specific manner. In other words, the leaf springs 151 have been compressed together and pre-tensioned to a specific desired value. Figure 3B In this configuration, the pre-tension force (or adjusted axial force) is now secured by the pressing element 160. In the example shown, the pressing element 160 is constructed in the form of a sleeve that is inserted into the valve body 140 in a cylindrical shape around the rotor shaft 130 in the axial direction A. Specifically, the pressing element 160 is pressed into the valve body 140 in a manner that provides a non-removable press-fit connection (or cylindrical press-fit) (here, directly pressed onto the axial bearing 152).

[0085] In other words, after being pressed in, the pressing element 160 is fixedly seated in the valve body 140 in such a way that it cannot be removed without damaging the components of the valve 100 (or without being pressed out). Therefore, the adjusted axial force P (axial pressure) achieved by the pretension of the leaf spring 151 in this example no longer changes. Thus, the constant pressure of the rotor device 131 on the dummy structure 180 has been adjusted.

[0086] However, ultimately, the adjusted axial force P is intended to act on both rotor element 120 and stator element 110; therefore, in the next step, the dummy structure 180 is removed and replaced by stator element 110 (see...). Figure 4 ).

[0087] In a preferred exemplary embodiment, the method according to Figure 3A The steps, and can be started directly according to Figure 3B The procedure involves simultaneously pressing in the pressing element 160 and adjusting the axial force P. In this case, the process is as follows: The pressing element 160 is slowly pressed into the valve body 140 by means of pressure. Simultaneously, the force is measured at the measuring device 181. Once the desired axial force P measured there is reached, the pressing process stops. The valve 100 is now fully adjusted. The dummy structure 180 is then removed and replaced by the attached rotor element 120 and stator element 110, resulting in a temporary relaxation of the leaf spring 151, but the same axial force P is subsequently adjusted again.

[0088] Figure 4 A cross-section of a valve 100 according to an exemplary embodiment of the present invention is shown. When Figure 3B When the dummy structure 180 is removed, the axial force P will initially decrease, or the leaf spring 151 will expand again. However, once the rotor element 120 is inserted and the stator element 110 is fixed in place of the dummy structure 180, the leaf spring 151 is pre-tensioned again as adjusted, and the axial force P reappears as previously adjusted. This state is... Figure 4As shown in the exemplary embodiment, the stator element 110 is detachably secured to the valve body 140 by a fastening device 115 (here, a screw). Accordingly, the axial force P is fixed in one direction of action by a non-detachable connection (press fit) and in the opposite direction of action by a detachable connection (detachable stator element 110).

[0089] The rotor boundary surface 121 of rotor element 120 and the stator boundary surface 111 of stator element 110 are now pressed against each other by an axial force P adjusted to a desired value (achieved by the pretension force of leaf spring 151).

[0090] Figure 5 Another example of a valve 100 according to an exemplary embodiment of the present invention is shown. In this embodiment, the entire valve 100 can be pre-installed without spring force. The final step involves using a pre-tensioning device 162, which applies the desired spring force to the axial bearing 152 via a pressing device. Thereafter, an adjusting screw 165 is attached with a defined torque. This method always ensures the same precise spring force and is easy to manufacture.

[0091] This manufacturing method allows for precise alignment of the adjusting screw 165. This enables better guidance of the rotor shaft 130 and the rotor seals. The production process can be very simple: in this way, the leaf spring 151 can be pre-tensioned to the desired force while the stator element 110 remains in its installed state.

[0092] In other words, during production, a pretension force is provided by compressing the spring 151 to the desired force by applying a specific pretensioning device 162. Subsequently, an adjusting screw 165 is screwed in to fix and retain / control the force applied by the pretensioning device 162, so that the pretensioning device 162 can be subsequently removed.

[0093] Figures 6A to 6C The diagram illustrates the axial force P in the regulating valve 100 during the insertion of the stator element 110, according to an exemplary embodiment of the present invention. Figure 3A , Figure 3B and Figure 4 The first manufacturing method has already been described, in which pressure is applied from the rotor side to the stator dummy structure 180 to adjust the desired axial force. Figures 6A to 6C Another manufacturing method is described, in which a blocking element 170 is provided on the rotor side and pressure is provided on the stator side. In other words, instead of a pressing element on the rotor side, the stator element 110 is pressed into the valve body 140 on the stator side.

[0094] Figure 6A Provide similar Figure 4The valve body 100 contains the rotor element 120 and stator element 110. However, the main difference lies in the fact that the blocking element 170 is cylindrically arranged around the rotor shaft 130. Here, the blocking element 170 is part of the valve body 140 and terminates behind the axial bearing 152. In other words, the blocking element 170 prevents the resilient element 150 from being further pushed into the valve body 140 under stator-side pressure. Conversely, because the resilient element 150 cannot escape due to the blocking element 170, the axial force on the stator side ensures that the resilient element 150 is pre-tensioned.

[0095] Figure 6B A measuring device (not shown) is provided on the rotor side (force measurement is schematically shown) so that the axial force acting on the stator side can be measured and observed. The stator element 110 is initially separated from the rotor element 120 and is now pressed into the valve body 100 by axial (stator side) pressure.

[0096] Figure 6C The stator element 110 is pressed into the valve body 140 by this pressure and abuts against the rotor element 120. Because the blocking element 170 prevents the spring from unfolding, the leaf spring 151 (elastic element 150) is pressed together. A measuring device (see force measurement) can determine which force acts on the elastic element 150. Simultaneously, this force measurement can be compared / correlated with the position of the inserted stator element 110. When the desired axial force is reached (achieved by adjusting the pretension of the leaf spring 151), the pressure on the stator element 110 can be stopped. At this point, the stator element 110 has been pressed into the valve body 140 in such a way that non-destructive release is impossible. Instead, the stator element 110 is fixed in the valve body 140 by a press-fit connection. Accordingly, the axial force P is also fixed, which is adjusted to press the rotor boundary surface 121 and the stator boundary surface 111 together. In this exemplary embodiment, the axial force P is fixed in two (opposite) directions of action by a non-detachable connection.

[0097] In another exemplary embodiment, the process may be as follows: force measurement will always measure pressure (not leaf spring force). The first press is performed without stator element 110 to find the position where the desired axial force P is achieved. Then, stator element 110 is pressed into that position.

[0098] In another exemplary embodiment, the process may be as follows: the stator element 110 is pressed in little by little, one time at a time, and then the rotor shaft 130 is pulled until it moves. The force that initiates the movement of the rotor shaft 130 corresponds to the axial force P.

[0099] Figure Labels

[0100] 10. Analytical apparatus

[0101] 20 Fluid Drives

[0102] 25 Supply Units

[0103] 27 Degasser

[0104] 30 Sample separation units

[0105] 40 syringes

[0106] 50 detectors

[0107] 60 Distillation Unit

[0108] 70 Control Unit

[0109] 100 valve

[0110] 110 Stator Components

[0111] 111 Stator boundary surface

[0112] 112 Fluid Port

[0113] 115 Fastening devices, screws

[0114] 120 Rotor Components

[0115] 121 Rotor boundary surface

[0116] 130 rotor shaft

[0117] 131 Rotor assembly

[0118] 132 Rotor Pin

[0119] 140 Valve Body

[0120] 150 elastic element

[0121] 151 Leaf Spring

[0122] 152 Axial Bearing

[0123] 153 Radial bearing

[0124] 155 Guide Element

[0125] 160 Pressing element

[0126] 162 Pre-tensioning device

[0127] 165 Adjusting screw

[0128] 170 blocking element

[0129] 180 pseudostructure

[0130] 181 Measuring device

[0131] 190 drive unit

[0132] Axial

[0133] P is the axial force.

Claims

1. A valve (100), in particular for an analysis device (10) for analyzing a fluid sample, the valve (100) comprising: a stator element (110) having a stator boundary surface (111); and a rotor element (120) having a rotor boundary surface (121); wherein the stator element (110) and the rotor element (120) are arranged along an axial direction (A); wherein the stator boundary surface (111) and the rotor boundary surface (121) are pressed against each other in the axial direction (A) by an axial force (P); and wherein the axial force (P) is fixed in at least one acting direction by a non-detachable connection.

2. The valve (100) according to claim 1, the non-detachable connection comprises at least one of the following features: wherein a form-fit connection, in particular a press-fit connection; a material connection, in particular one of an adhesive connection, a solder connection, a soldering connection; and / or wherein the non-detachable connection does not comprise a detachable connection element, in particular a screw.

3. The valve (100) according to any one of the preceding claims, the axial force (P) comprises a spring force; and / or wherein wherein the axial force (P) is fixed to a predetermined value.

4. The valve (100) according to any one of the preceding claims, comprising at least one of the following features: the valve (100) is configured as a rotary valve, in particular a rotary shear valve; wherein, wherein the valve (100) is configured as a high-pressure valve; wherein the valve (100) is configured as a fluid valve, in particular a fluid switching valve; wherein the axial force (P) closes the valve (100) in a fluid-tight manner.

5. The valve (100) according to any one of the preceding claims, comprising: a rotor shaft (130) coupled to the rotor element (120), in particular by a drive pin; wherein the rotor shaft (130) is configured to enable a rotation of the rotor element (120), and wherein the rotor shaft (130) is arranged along the axial direction (A).

6. The valve (100) according to any one of the preceding claims, comprising: at least one elastic element (150) arranged along the axial direction (A) and configured to provide at least a portion of the axial force (P). the elastic element (150) comprises at least one of the following features:

7. The valve (100) according to any one of the preceding claims, wherein the elastic element (150) is configured as a spring, in particular a leaf spring (151); the elastic element (150) is configured as a cylinder; the elastic element (150) is arranged around the rotor shaft (130), in particular in a cylindrical shape.

8. The valve (100) according to any one of the preceding claims, comprising: a pressing element (160), in particular a pressing sleeve, fixed in the axial direction (a) by a press-fit connection; in particular, wherein the pressing element (160) comprises at least one of the following features: the pressing element (160) is configured as a cylinder; the pressing element (160) is arranged around the rotor shaft (130), in particular in a cylindrical shape; ​ wherein the elastic element (150) is arranged between the pressing element (160) and the rotor element (120).

9. The valve (100) according to any one of the preceding claims, comprising: a blocking element (170) arranged along the axial direction (A) and configured to block the elastic element (150) from expanding in an active direction; In particular, wherein the blocking element (170) comprises at least one of the following features: the blocking element (170) is configured as a part of the valve body (140); the blocking element (170) is arranged around the rotor shaft (130), in particular cylindrically; wherein the elastic element (150) is arranged between the blocking element (170) and the rotor element (120).

10. The valve (100) according to any one of the preceding claims, comprising: an axial bearing (152), in particular arranged between the pressing element (160) or the blocking element (170) and the elastic element (150); and / or a radial bearing (153), in particular arranged between the elastic element (150) and the rotor element (120).

11. The valve (100) according to any one of the preceding claims, comprising: a valve body (140), wherein at least a part of the rotor element (120) and the stator element (110) are arranged in the valve body (140).

12. The valve (100) according to any one of the preceding claims, wherein the stator element (110) is fastened to the valve body (140), in particular by a detachable connection (115), further in particular by a screw connection.

13. The valve (100) according to any one of the preceding claims, wherein, the stator element (110) is fixed in the valve body (140) by a press fit connection.

14. The valve (100) according to any one of the preceding claims, comprising at least one of the following features: wherein, the valve (100) is free of an adjustment mechanism, in particular free of an adjustment screw; wherein the valve (100) is configured to be operated in a maintenance-free manner; wherein an adjusted axial force (P) in the valve (100) cannot be changed; wherein the stator element (110) is replaceable; wherein the stator element (110) and / or the rotor element (120) comprise at least one of the following materials: metal, in particular stainless steel, ceramic, plastic.

15. An analysis device (10) for analyzing a fluid sample, comprising: an analysis system (30); and at least one valve (100) according to any one of the preceding claims.

16. The analysis device (10) according to claim 15, further comprising at least one of the following features: the analysis device (10) is configured as a sample separation device; the analysis device (10) comprises a fluid driver (20) for driving a mobile phase and a fluid sample injected into the mobile phase; The analysis device (10) comprises a sample separation unit (30) for separating the fluid sample injected into the mobile phase; The analysis device (10) is configured for analyzing at least one of a physical, chemical and / or biological parameter of the fluid sample; The analysis device (10) is configured as a sample separation device for separating the fluid sample; The analysis device (10) is a chromatography device, in particular a liquid chromatography device, a gas chromatography device, an SFC (supercritical fluid chromatography) device or an HPLC (high performance liquid chromatography) device; The analysis device (10) is configured as a microfluidic device; The analysis device (10) is configured as a nanofluidic device; The sample separation unit (30) is configured as a chromatography separation unit, in particular a chromatography separation column; The fluid driver (20) is configured to drive the mobile phase and the fluid sample at high pressure; The fluid driver (20) is configured to drive the mobile phase and the fluid sample at a pressure of at least 500 bar, in particular at least 1000 bar, further in particular at least 1200 bar; The analysis device (10) comprises a detector (50) for detecting the analyzed, in particular separated, fluid sample; The analysis device (10) comprises a fractionator (60) for fractionating separated fractions of the fluid sample.

17. A method for manufacturing a valve (100) comprising a stator element (110) and a rotor element (120) which are pressed against each other in an axial direction (A) by an axial force (P), the method comprising: adjusting the axial force (P); and fixing the axial force (P) in at least one direction of action by a non-detachable connection.

18. The method according to claim 17, comprising: pre-mounting at least one elastic element (150) in a valve body (140); and pressing a pressing element (160) into the valve body (140) in order to adjust the axial force (P) by the elastic element (150) and to fix the adjusted axial force (P) while providing a non-detachable connection, in particular while measuring the axial force (P) during pressing.

19. The method according to claim 17 or 18, comprising: pre-mounting at least one elastic element (150) in a valve body (140); blocking expansion of the elastic element (150) in one direction by a blocking element (170); and pressing the stator element (110) into the valve body (140) in order to adjust the axial force (P) by the elastic element (150) against the blocking element (170) and to fix the adjusted axial force (P) while providing a non-detachable connection, in particular while measuring the axial force (P) during pressing.

20. The method according to any one of claims 17 to 19, comprising: During the adjustment of the axial force (P), a dummy structure (180), in particular configured to measure the axial force (P), is applied at the position of the rotor element (110) and / or at the position of the stator element (120).

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