Attaching tool to movable station

Abstract

A movable station assembly includes a movable station; a threaded aperture, the threaded aperture being defined in the movable station; and an electrical connector, the electrical connector being coupled to the movable station.

Description

Cross Reference to Related Patent Applications

[0001] This application is a non-provisional application claiming the benefit of priority to U.S. Provisional Patent Application No. 63 / 503,449, filed May 19, 2023, entitled “Automated Liquid Handling Systems, Tools, and Calibrations,” and incorporates the entirety of that U.S. Provisional Patent Application. TECHNICAL FIELD

[0002] The present disclosure relates generally to liquid handling systems. In particular, the present disclosure relates to systems and methods for attaching tools, such as pipettes and grippers, to a movable stage of a liquid handling system. BACKGROUND

[0003] Liquid handling systems can include robotic elements and a plurality of selectively couplable pipettes that can be coupled to a movable stage. The movable stage facilitates moving the pipettes and precisely placing the pipettes over receptacles, such as reaction vessels or devices for reacting liquid solutions dispensed by the pipettes. In one example, the pipettes, receptacles, and / or devices for reacting liquid solutions can be positioned within an enclosed space in which reactions can be isolated from any external environment to ensure that no other objects can interrupt the processes of the liquid handling system and / or reactions occurring within the enclosed space.

[0004] In some cases, laboratory work or other processes can require different pipette form factors, including, for example, single-channel pipettes, eight-channel pipettes, 96-channel pipettes, N-channel pipettes (where N is any integer greater than or equal to 1), and combinations thereof. In some cases, it can be desirable to switch different pipette form factors to obtain different throughputs within a liquid handling system, provide different types of reactions, speed up the processing of large numbers of reactions, or for other reasons. However, in some liquid handling systems, a user, such as a laboratory operator of the liquid handling system, can not be able to switch from a first pipette form factor to a second pipette form factor because such a switch can require a specialized operator, service provider, or technician to make the switch. For such a specialized operator, service provider, or technician, the process can take hours or days to reach the location of the liquid handling system and make the switch of the pipette form factor. This can significantly reduce the throughput of laboratory work provided by the liquid handling system. BRIEF DESCRIPTION OF DRAWINGS

[0005] The detailed description is set forth with reference to the accompanying drawings. In the drawings, the left-most numeral at the left of a reference designates the figure in which that reference first appears. The use of the same reference designations in different figures indicates similar or identical items. The systems depicted in the drawings are not drawn to scale and the components in the figures can not be to scale with one another.

[0006] Figure 1 A perspective view of a movable stage assembly including a movable stage and a first pipettor and a second pipettor is illustrated according to an example of the principles described herein.

[0007] Figure 2 A perspective view of a movable stage is illustrated according to an example of the principles described herein. Figure 1 in a first state.

[0008] Figure 3 A perspective view of a movable stage is illustrated according to an example of the principles described herein. Figure 1 in a second state and including a first adapter.

[0009] Figure 4 A perspective view of a movable stage is illustrated according to an example of the principles described herein as depicted in circle A of Figure 3 Figure 1 A perspective view of a movable stage is illustrated according to an example of the principles described herein.

[0010] Figure 5 A perspective view of a movable stage is illustrated according to an example of the principles described herein. Figure 1 in a second state and including a second adapter.

[0011] Figure 6 A perspective view of a movable stage is illustrated according to an example of the principles described herein as depicted in circle B of Figure 5 Figure 1 A perspective view of a movable stage is illustrated according to an example of the principles described herein.

[0012] Figure 7 A perspective view of a movable stage assembly including a movable stage and a first pipettor and a third pipettor is illustrated according to an example of the principles described herein. Figure 1

[0013] A perspective view of a movable stage assembly including a movable stage and a fourth pipettor is illustrated according to an example of the principles described herein. Figure 8 Figure 1 A perspective view of a movable stage assembly including a movable stage and a fourth pipettor is illustrated according to an example of the principles described herein.

[0014] Figure 9 A perspective view of a movable stage assembly including a movable stage and a fourth pipettor is illustrated according to an example of the principles described herein. Figure 1 A perspective view of a movable stage assembly including a movable stage and a fourth pipettor is illustrated according to an example of the principles described herein.​​​

[0015] Figure 10 FIG. 1 illustrates a perspective view of a liquid handling system according to an example of the principles described herein. Figure 1 FIG. 2 illustrates a partial cutaway perspective view of a first pipettor of the liquid handling system of FIG. 1.

[0016] Figure 11 FIG. 3 illustrates a computing system diagram illustrating a configuration of a liquid handling system that can be used to implement aspects of the technology disclosed herein.

[0017] Figure 12 FIG. 4 illustrates a perspective view of a liquid handling system according to an example of the principles described herein. Figure 11

[0018] Figure 13 FIG. 5 illustrates a perspective view of a movable stage assembly including a movable stage and a gripper device according to an example of the principles described herein.

[0019] Figure 14 FIG. 6 illustrates a first perspective exploded view of a movable stage assembly including a movable stage and a gripper device according to an example of the principles described herein.

[0020] Figure 15 FIG. 7 illustrates a second perspective exploded view of a movable stage assembly including a movable stage and a gripper device according to an example of the principles described herein. DETAILED DESCRIPTION

[0021] SUMMARY

[0022] The present disclosure describes systems and methods of switching a plurality of selectively couplable pipettors having different shape parameters. The plurality of different pipettor shape parameters can be selectively coupled and decoupled with a z-stage of a movable stage within a liquid handling system. The different pipettor shape parameters can each include a single dispensing pipettor, eight dispensing pipettors, 96 dispensing pipettors, N dispensing pipettors (where N is any integer greater than or equal to 1) in a single dispensing head to allow the dispensing head to dispense a liquid solution into a single receptacle and / or device (in the case of a single channel pipettor), or into multiple receptacles and / or devices (in the case of an eight channel pipettor, a 96 channel pipettor, and / or an N channel pipettor (where N is any integer greater than or equal to 1). Having multiple dispensing heads within a single pipettor device can speed up laboratory work that a liquid handling system can be programmed to perform for a user, as a corresponding plurality of receptacles and / or devices can be used simultaneously in conjunction with the liquid handling system.

[0023] ​A z-stage of a moveable stage can include a plurality of moveable pipette mounts that allow one or more of different pipette form factors to be coupled to the z-stage. The moveable pipette mounts can be moveable in the z-direction to allow different pipette form factors to be moved in proximity to a vessel, a device for reacting a liquid solution, or other elements positioned within and housed within an enclosed space of a liquid handling system on a deck. At least one of the moveable pipette mounts can include a mounting head, a head fastener, and a mounting base removably coupled to the mounting head via the head fastener. Disengagement of the head fastener allows separation of the mounting head and the mounting base to allow one of the different pipette form factors to be coupled to the z-stage, such as, for example, a 96-channel pipette. Engagement of the head fastener allows coupling of the mounting head and the mounting base to allow one of the different pipette form factors to be coupled to the z-stage, such as, for example, a single-channel pipette and / or an eight-channel pipette.

[0024] Examples described herein provide a moveable stage assembly including a moveable stage; a threaded aperture defined in the moveable stage; and an electrical connector coupled to the moveable stage. The moveable stage assembly can further include a tool coupled to the moveable stage. The tool can include a pipette or a gripper device.

[0025] The moveable stage assembly can further include a moveable pipette mount coupled to the moveable stage and moveable along a length of the moveable stage. The moveable pipette mount can mount a pipette to the moveable stage. The threaded aperture can be defined in the moveable pipette mount and the pipette can include a mating captive fastener for engagement with the threaded aperture. The moveable stage assembly can further include a moveable pipette mount coupled to the moveable stage and moveable along a length of the moveable stage. The moveable pipette mount can mount a pipette to the moveable stage. The electrical connector can include a first electrical connector coupled to the moveable pipette mount of the moveable stage. The pipette can include a second electrical connector matablely engageable with the first electrical connector.

[0026] The movable stage assembly can further include a movable pipette mount coupled to the movable stage and movable along a length of the movable stage. The movable pipette mount can mount a pipette to the movable stage. The movable stage assembly can further include a locating pin coupled to the movable stage and protruding from the movable stage. The locating pin can be coupled to and protrude from the movable pipette mount of the movable stage, wherein the locating pin is configured to engage with a locating pin aperture defined in the pipette.

[0027] The movable stage assembly can further include a gripper mount formed on the movable stage for mounting a gripper device to the movable stage. The gripper mount can include a threaded aperture defined in the gripper mount formed on the movable stage; an electrical connector coupled to the gripper mount formed on the movable stage; and a locating pin aperture defined in the gripper mount formed on the movable stage. The locating pin aperture can be configured to receive a locating pin coupled to and protruding from the gripper device.

[0028] The movable stage assembly can further include an alignment indicator defined on the movable stage for visually aligning a tool with the movable stage. The alignment indicator can include a horizontal alignment indicator and a vertical alignment indicator.

[0029] Examples described herein also provide a tool mounting system including a threaded aperture defined in a movable stage for mechanically coupling a tool to the movable stage. The tool can include a mating fastener for engaging with the threaded aperture. The tool mounting system can further include a first electrical connector coupled to the movable stage for electrically coupling the tool to the movable stage. The tool can include a second electrical connector matablely engageable with the first electrical connector. The tool mounting system can further be a locating pin system for aligning the tool with the movable stage. The tool can include a pipette or a gripper device.

[0030] The positioning pin system can include a positioning pin coupled to the movable stage and protruding from the movable stage; and a positioning pin aperture defined in the pipettor. The positioning pin can be configured to engage with the positioning pin aperture defined in the pipettor to align the pipettor relative to the movable stage. The positioning pin system can include a positioning pin coupled to the gripper device and protruding from the gripper device; and a positioning pin aperture defined in the movable stage. The positioning pin can be configured to engage with the positioning pin aperture defined in the movable stage to align the gripper device relative to the movable stage.

[0031] The positioning pin system can include a gripper mount formed on the movable stage for mounting the gripper device to the movable stage. The gripper mount can include a threaded aperture defined in the gripper mount formed on the movable stage; and a first electrical connector coupled to the gripper mount formed on the movable stage cooperatively engageable with a second electrical connector formed on the gripper device.

[0032] The tool mounting system can further include an alignment indicator defined on the movable stage for visually aligning the tool with the movable stage. The alignment indicator can include a horizontal alignment indicator and a vertical alignment indicator.

[0033] The mating fastener can include a captive screw secured within the tool. The first electrical connector or the second electrical connector can include spring-biased electrical contacts. The first electrical connector or the second electrical connector can include an electrical power connection and a communication signal connection.

[0034] Examples described herein also provide a movable stage assembly including a movable stage; a first movable pipettor mount coupled to the movable stage and movable along a length of the movable stage; and a second movable pipettor mount coupled to the movable stage and movable along a length of the movable stage. The second movable pipettor mount can include a mounting head, a head fastener, and a mounting base removably coupled to the mounting head via the head fastener.

[0035] The movable stage assembly can further include a first threaded aperture defined by the first movable pipette mount for coupling the first pipette to the first movable pipette mount; and a second threaded aperture defined by the second movable pipette mount for coupling the second pipette to the second movable pipette mount. The movable stage assembly can further include a mounting bolt coupled to the mounting base. The head fastener can include a captive screw that removably couples the mounting head to the mounting base via selective engagement with the mounting bolt.

[0036] The movable stage assembly can further include a first electrical connector coupled to the first movable pipette mount; and a second electrical connector coupled to the second movable pipette mount. The first electrical connector and the second electrical connector electrically couple the first pipette and the second pipette to the first movable pipette mount and the second movable pipette mount, respectively.

[0037] The movable stage assembly can further include a first pipette positioning pin coupled to and protruding from the first movable pipette mount; and a second pipette positioning pin coupled to and protruding from the second movable pipette mount. The first pipette positioning pin aligns the first electrical connector with a first pipette electrical connector formed on the first pipette when engaged with the first pipette, and the second pipette positioning pin aligns the second electrical connector with a second pipette electrical connector formed on the second pipette when engaged with the second pipette.

[0038] The movable stage assembly can further include an adapter selectively coupleable to and bridging the first movable pipette mount and the second movable pipette mount. The movable stage assembly can further include a hanger bar coupled to and protruding from the adapter. The hanger bar can align the first electrical connector or the second electrical connector with a third pipette electrical connector formed on a third pipette when engaged with the third pipette.

[0039] Examples described herein also provide a pipette system including a movable stage. The movable stage can include a first movable pipette mount coupled to the movable stage and movable along a length of the movable stage; and a second movable pipette mount coupled to the movable stage and movable along the length of the movable stage. The second movable pipette mount can include a mounting head, a head fastener, and a mounting base removably coupled to the mounting head via the head fastener.

[0040] The pipette system can further include a display device; a processor communicatively coupled to the display device; and a non-transitory computer-readable medium storing instructions that, when executed by the processor, cause the processor to perform operations. The operations can include presenting, on the display device communicatively coupled to the pipette system, a command presenting at least one step for mounting the first pipette, the second pipette, and the third pipette to the first movable pipette mount and the second movable pipette mount of the movable stage and removing the first pipette, the second pipette, and the third pipette from the first movable pipette mount and the second movable pipette mount of the movable stage.

[0041] The operations can further include detecting whether the first pipette, the second pipette, or the third pipette is coupled to the first movable pipette mount or the second movable pipette mount, and moving the first movable pipette mount and the second movable pipette mount based at least in part on the detection of the first pipette, the second pipette, or the third pipette being coupled to the first movable pipette mount or the second movable pipette mount.

[0042] The pipette system can further include a first threaded aperture defined by the first movable pipette mount for coupling the first pipette to the first movable pipette mount; and a second threaded aperture defined by the second movable pipette mount for coupling the second pipette to the second movable pipette mount. The pipette system can further include a mounting bolt coupled to the mounting base. The head fastener includes a captive screw for removably coupling the mounting head to the mounting base via selective engagement with the mounting bolt.

[0043] The pipette system can further include a first electrical connector coupled to the first movable pipette mount; and a second electrical connector coupled to the second movable pipette mount. The first electrical connector and the second electrical connector electrically couple the first pipette and the second pipette to the first movable pipette mount and the second movable pipette mount, respectively. The pipette system can further include a first pipette positioning pin coupled to and protruding from the first movable pipette mount; and a second pipette positioning pin coupled to and protruding from the second movable pipette mount.

[0044] The first pipette positioning pin aligns the first electrical connector with a first pipette electrical connector formed on the first pipette when the first pipette is engaged. Further, the second pipette positioning pin aligns the second electrical connector with a second pipette electrical connector formed on the second pipette when the second pipette is engaged.

[0045] The pipette system can further include an adapter selectively coupleable to the first movable pipette mount and the second movable pipette mount and bridging the first movable pipette mount and the second movable pipette mount; and a suspension bar coupled to and protruding from the adapter. The suspension bar aligns the first electrical connector coupled to the first movable pipette mount or the second electrical connector coupled to the second movable pipette mount with a third pipette electrical connector formed on the third pipette when the third pipette is engaged.

[0046] Examples described herein also provide a method that includes detecting whether a first pipette, a second pipette, or a third pipette is coupled to a first movable pipette mount or a second movable pipette mount of a movable stage, and moving the first movable pipette mount and the second movable pipette mount based at least in part on the detection of the first pipette, the second pipette, or the third pipette being coupled to the first movable pipette mount or the second movable pipette mount.

[0047] The method can further include, in response to a determination that the first pipette, the second pipette, or both the first pipette and the second pipette are coupled to the first movable pipette mount, the second movable pipette mount, or both the first movable pipette mount and the second movable pipette mount, respectively, moving the first movable pipette mount and the second movable pipette mount independently of one another. The method can further include, in response to a determination that the third pipette is coupled to the first movable pipette mount and the second movable pipette mount, moving the first movable pipette mount and a mounting base together, the mounting base being removably coupled to a mounting head of the second movable pipette mount. The method can further include presenting, on a display device communicatively coupled to the movable stage, a command presenting at least one step for mounting the first pipette, the second pipette, and the third pipette to the first movable pipette mount and the second movable pipette mount of the movable stage, and removing the first pipette, the second pipette, and the third pipette from the first movable pipette mount and the second movable pipette mount of the movable stage.

[0048] Furthermore, the techniques described in this disclosure can be performed as methods and / or by systems having non-transitory computer- readable media storing computer-executable instructions that, when executed by one or more processors, perform the techniques described above.

[0049] Exemplary Embodiments

[0050] The present disclosure describes a movable stage for a pipette system. The movable stage can include a first movable pipette mount coupled to the movable stage and movable along a length of the movable stage, and a second movable pipette mount coupled to the movable stage and movable along the length of the movable stage. The first movable pipette mount and the second movable pipette mount can be movable in a direction that places pipettes coupled to the first movable pipette mount and the second movable pipette mount closer to a vessel, a device for reacting a liquid solution, or other element positioned within an enclosed space of a liquid handling system and positioned on a deck housed within the enclosed space of the liquid handling system. At least one of the first movable pipette mount and the second movable pipette mount can include a mounting head, a head fastener, and a mounting base removably coupled to the mounting head via the head fastener.

[0051] Certain specific embodiments and implementations of the present disclosure will now be described, by way of example, with reference to the drawings, in which various aspects are shown. The various aspects can, however, be implemented in many different forms and should not be construed as limited to the particular embodiments set forth herein. As described herein, the present disclosure encompasses variations of the embodiments. Like reference numerals refer to like elements throughout.

[0052] Figure 1 A perspective view of a movable stage assembly 100 including a movable stage 102 and a first pipettor 104-1 and a second pipettor 104-2 is illustrated in accordance with an example of the principles described herein. Figure 1 The first pipettor 104-1 and the second pipettor 104-2 depicted in FIG. 1 include single channel pipettor shape parameters, where each of the first pipettor 104-1 and the second pipettor 104-2 is capable of dispensing from a single pipettor nozzle (e.g., a single channel pipettor); namely, a first pipettor nozzle 106-1 and a second pipettor nozzle 106-2, respectively. In one example, the first pipettor 104-1 and the second pipettor 104-2 can be capable of dispensing, for example, up to 50 microliters (pL) of fluid. In one example, the first pipettor 104-1 and the second pipettor 104-2 can be capable of dispensing, for example, up to 1,000 pL of fluid. However, the first pipettor 104-1 and the second pipettor 104-2 can be designed to be capable of carrying and / or dispensing a fluid of any volume range. Further, the first pipettor 104-1 and the second pipettor 104-2 can be provided and / or sold as, for example, a 20 pL pipettor, a 50 pL pipettor, a 200 pL pipettor, a 300 pL pipettor, a 1,000 pL pipettor, or other type of pipettor capability.

[0053] To understand some of the many functions of the movable assembly 100, reference can be made to Figures 7 to 9 . Figure 7 A perspective view of a movable stage assembly 100 including a movable stage 102 and a second pipettor 104-2 and a third pipettor 702 is illustrated in accordance with an example of the principles described herein. Figure 1 . Figure 7A third pipettor 702 is depicted, which includes an array 704 of eight pipettor tips (e.g., an eight-channel pipettor). In one example, the third pipettor 702 can be capable of dispensing fluids up to, for example, 50 μΐ^. In one example, the first pipettor 104-1 and the second pipettor 104-2 can be capable of dispensing fluids up to, for example, 1,000 μΐ^. However, the third pipettor 702 can be designed to be capable of carrying and / or dispensing fluids of any volume range. Further, the third pipettor 702 can be provided and / or sold as, for example, a 20 μΐ^ pipettor, a 50 μΐ^ pipettor, a 200 μΐ^ pipettor, a 300 μΐ^ pipettor, a 1,000 μΐ^ pipettor, or other type of pipettor volume capability.

[0054] Further, Figure 8 A perspective view of the movable stage assembly 100 of Figure 1 A perspective view of the movable stage assembly 100 of Figure 9 A perspective view of the movable stage assembly 100 of Figure 1 A perspective view of the movable stage assembly 100 of Figure 8 A perspective view of the movable stage assembly 100 of Figure 9A fourth pipettor 802 is depicted, which includes an array 804 of 96 pipettor tips (e.g., a 96-channel pipettor). Any number of pipettor tips can be included within a pipettor that can be coupled to the movable stage 102 including an N-channel pipettor (where N is any integer greater than or equal to 1) to provide any number of channels of liquid solution to be dispensed from the pipettor. In one example, the fourth pipettor 802 can be capable of dispensing fluids, for example, up to 1,000 μΐ^. In one example, the fourth pipettor 802 can be capable of dispensing fluids, for example, up to 10,000 μΐ^. However, the fourth pipettor 802 can be designed to be capable of carrying and / or dispensing fluids of any range of volumes. Further, the fourth pipettor 802 can be provided and / or sold as, for example, a 100 μΐ^ pipettor, a 200 μΐ^ pipettor, a 500 μΐ^ pipettor, a 1,000 μΐ^ pipettor, a 10,000 μΐ^ pipettor, or other type of pipettor volume capability. In addition to differing in size, in further differentiating the first pipettor 104-1 and the second pipettor 104-2 and the third pipettor 702 from the fourth pipettor 802, the fourth pipettor 802 can be capable of dispensing and / or holding a much larger volume of liquid, and the fourth pipettor 802 can again be relatively heavier with or without fluid contained within the fourth pipettor 802. In one example, the fourth pipettor 802 can weigh between 20 and 50 pounds (lbs.) when loaded with fluid or not loaded with fluid. However, the fourth pipettor 802 can weigh any number of pounds.

[0055] As Figure 1 and Figures 7 to 9As depicted herein, the first pipette 104-1, the second pipette 104-2, the third pipette 702, and the fourth pipette 802 have different shape parameters or dimensions occupying a portion of the movable stage 102. For example, the first pipette 104-1, the second pipette 104-2, and the third pipette 702 may have shape parameters occupying half the space on the movable stage 102, and due to their relative dimensions and / or mass, may each be individually coupled to one of at least two movable pipette mounts, as described in more detail herein. Furthermore, for example, the fourth pipette 802 may have shape parameters occupying the entire space on the movable stage 102, and due to its size and / or mass, may be coupled to two or more of the at least two movable pipette mounts, as described in more detail herein. In one example, disposable pipette tips may or may not be attached to the tips of the first pipette 104-1, the second pipette 104-2, the third pipette 702, and the fourth pipette 802, respectively. The pipette tips allow for the dispensing of liquid solutions into reservoirs and / or devices used to directly react the liquid solutions, ensuring that the liquid solutions do not splash into other parts of the reaction area of ​​the liquid handling system or otherwise contaminate other reactions.

[0056] like Figure 1 and Figures 7 to 10 As depicted, the first pipette 104-1, second pipette 104-2, third pipette 702, and fourth pipette 802 may include recesses defined in the front portions of the first pipette 104-1, second pipette 104-2, third pipette 702, and fourth pipette 802, in which a pipette retaining screw can be held. For example, the first pipette 104-1 may include a first recess 108-1 and a second recess 108-2. Similarly, the second pipette 104-2 may include a third recess 110-1 and a fourth recess 110-2. Furthermore, the third pipette 702 may include a fifth recess 706-1 and a sixth recess 706-2. Similarly, the fourth pipette 802 may include a seventh recess 806-1, an eighth recess 806-2, a ninth recess 806-3, and a tenth recess 806-4. The pipettes described herein may include any number of recesses defined therein, including a corresponding number of pipette tethering screws. Figure 9 Examples illustrating the principles described herein include a movable stage and a fourth pipette. Figure 1 A partial sectional perspective view of the movable stage component. Furthermore, Figure 10 Examples based on the principles described herein are illustrated. Figure 1 A partial cross-sectional perspective view of the first pipette. (See image) Figure 9 andFigure 10 As depicted in , the pipette captive screw may be retained in a recess including a first recess 108-1, a second recess 108-2, a third recess 110-1, a fourth recess 110-2, a fifth recess 706-1, a sixth recess 706-2, a seventh recess 806-1, an eighth recess 806-2, a ninth recess 806-3, and a tenth recess 806-4.

[0057] exist Figure 9 In the diagram, the pipette tether screw 902 is depicted in the tenth recess 806-4 of the fourth pipette 802. Figure 10 In this context, the pipette tether screw 1002 is depicted in the second recess 108-2 of the first pipette 104-1, or in the fourth recess 110-2 of the second pipette 104-2 (since the first pipette 104-1 and the second pipette 104-2 are identical in form). This description of the pipette tether screw can be applied to all tether screws included within recesses (e.g., the first recess 108-1, the second recess 108-2, the third recess 110-1, the fourth recess 110-2, the fifth recess 706-1, the sixth recess 706-2, the seventh recess 806-1, the eighth recess 806-2, the ninth recess 806-3, and the tenth recess 806-4). Figure 9 The pipette tether screw 902 depicted is shown from the front side of the pipette tether screw 902 and the fourth pipette 802. Figure 10 The tethering screw 1002 depicted is drawn from the rear side of the first pipette 104-1.

[0058] Figure 9 and Figure 10 The tethering screws 902 and 1002 depicted may each include heads 904 and 1004, through which a rotational torque can be applied by a tool such as a drive. The heads 904 and 1004 can be configured to engage with any type of drive tool, which includes, for example... Figure 9 The hexagonal actuator (e.g., hexagonal sleeve actuator) depicted in the text.

[0059] Figure 9 and Figure 10The pipette retainer screws 902 and 1002 depicted may also include threaded shanks 906 and 1006 that can engage with the movable stage 102 to couple the first pipette 104-1, the second pipette 104-2, the third pipette 702, and the fourth pipette 802 to the movable stage 102. The threaded shanks 906 and 1006 may include threads that engage with corresponding threads formed in orifices defined in the movable stage 102. Specifically, the corresponding pipette mounting holes 232-1, 232-2, 232-3, 232-4, 232-5, 232-6, 232-7 and 232-8 (collectively referred to herein as pipette mounting holes 232) may include corresponding threads that engage with the threaded shanks 906 and 1006 of the pipette retainer screws 902 and 1002.

[0060] Figure 9 and Figure 10 The tethering screws 902 and 1002 depicted may also include springs 908 and 1008 surrounding the threaded shanks 906 and 1006. Furthermore, as... Figure 10 As depicted, the retainer can be coupled to the tether screws 902 and 1002 to hold them within the first recess 108-1, the second recess 108-2, the third recess 110-1, the fourth recess 110-2, the fifth recess 706-1, the sixth recess 706-2, the seventh recess 806-1, the eighth recess 806-2, the ninth recess 806-3, and the tenth recess 806-4. In this way, the tether screws 902 and 1002 are held (e.g., tethered) within the recesses. This ensures that the tether screws 902 and 1002 are held within the first pipette 104-1 and the second pipette 104-2, the third pipette 702, and the fourth pipette 802, respectively, and ensures that individuals seeking to separate and couple the pipettes can do so without having to handle the screws or risk losing them.

[0061] The threaded shanks 906 and 1006 of the tether screws 902 and 1002 can protrude from orifices 1012-1 and 1012-2 defined in the back of the first pipette 104-1, the second pipette 104-2, the third pipette 702, and the fourth pipette 802. Springs 908 and 1008 coupled to the threaded shanks 906 and 1006 are biased to cause the tether screws 902 and 1002 in the recesses to protrude beyond the orifices 1012-1 and 1012-2 to a desired extent, allowing the ends of the threaded shanks 906 and 1006 to move into corresponding and mating orifices defined in the movable stage 102. When the actuator tool is pushed into the recess at the front of the pipette, the user can overcome the bias of springs 908 and 1008 and engage with the heads 904 and 1004 of the tether screws 902 and 1002, and force is applied to the tether screws 902 and 1002 along their axes. When force is applied to the tether screws 902 and 1002 in this way, the threaded shanks 906 and 1006 of the tether screws 902 and 1002 can further protrude beyond the orifices 1012-1 and 1012-2, as... Figure 10 As depicted in the figure. The user can rotate the tether screws 902 and 1002 by engaging the actuator tool, and cause the threaded shanks 906 and 1006 of the tether screws 902 and 1002 to engage with corresponding and mating orifices defined in the movable stage 102 to couple the first pipette 104-1 and the second pipette 104-2, the third pipette 702 and the fourth pipette 802 to the movable stage 102.

[0062] The different pipette shape parameters and how the pipette can be coupled to the movable stage 102 have been described. The description of the movable stage 102 will now be described. Figure 2 Examples based on the principles described herein are illustrated. Figure 1perspective view of the movable stage 102 in a first state. The movable stage 102 can include a first movable pipette mount 202-1 coupled to a first half of the movable stage 102; and a second movable pipette mount 202-2 coupled to a second half of the movable stage 102. The first movable pipette mount 202-1 and the second movable pipette mount 202-2 can be mechanically and electrically coupled to the movable stage 102 such that the first movable pipette mount 202-1 and the second movable pipette mount 202-2 can be moved along a z-axis of the movable stage 102, as depicted by the coordinate notation indicated throughout the figures. The first movable pipette mount 202-1 and the second movable pipette mount 202-2 allow pipettes coupled thereto to be moved in the z-direction (e.g., vertically up and down along the z-axis) to allow the pipettes to dispense liquid solutions as described herein.

[0063] In one example, the first movable pipette mount 202-1 and the second movable pipette mount 202-2 can be mechanically coupled to the movable stage 102 via a rail system or other mechanical system that allows the first movable pipette mount 202-1 and the second movable pipette mount 202-2 to be moved up and down in the z-direction while remaining in a coupled state with the movable stage 102. Further, in one example, the first movable pipette mount 202-1 and the second movable pipette mount 202-2 can be mechanically coupled to a drive device, such as, for example, a worm screw, that when rotated, can cause the first movable pipette mount 202-1 and the second movable pipette mount 202-2 to move up and down when driven by a motor. The motor can be actuated via signals sent from the hardware and / or software of the liquid handling system. However, any means can be employed in moving the first movable pipette mount 202-1 and the second movable pipette mount 202-2 in the z-direction along the front surface of the movable stage 102.

[0064] The first movable pipette mount 202-1 and the second movable pipette mount 202-2 can include a first electrical connector 204-1 and a second electrical connector 204-2. The first electrical connector 204-1 and the second electrical connector 204-2 can be electrically coupled to the hardware and / or software of the liquid handling system to which the movable stage 102 is coupled. Further, the first electrical connector 204-1 and the second electrical connector 204-2 can serve as conduits through which the hardware and / or software of the liquid handling system can instruct pipettes coupled thereto to dispense liquid solutions based on signals sent to the pipettes via the first electrical connector 204-1 and / or the second electrical connector 204-2.

[0065] In conjunction with the first electrical connector 204-1 and the second electrical connector 204-2, Figure 10 A first pipette 104-1 including a pipette electrical connector 1016 is depicted. Although depicted in conjunction with the first pipette 104-1 in Figure 10 At least one pipette electrical connector 1016 can be included in each of the first pipette 104-1, the second pipette 104-2, the third pipette 702, and the fourth pipette 802, such that any pipette having any type of shape parameter can be electrically coupled with the movable stage 102 and the hardware and / or software of the liquid handling system. Accordingly, the first electrical connector 204-1 and the second electrical connector 204-2 can be electrically and / or mechanically coupled with the pipette electrical connector 1016. In the example presented herein, the first electrical connector 204-1 and the second electrical connector 204-2 are male connectors, and the pipette electrical connector 1016 is a female connector. However, in other examples, the first electrical connector 204-1 and the second electrical connector 204-2 can be female connectors, and the pipette electrical connector 1016 can be a male connector. Further, the first electrical connector 204-1, the second electrical connector 204-2, and the pipette electrical connector 1016 can include shape parameters that differ from those depicted herein, including different sizes, shapes, numbers of pin connectors, types of electrical connections, and the like.

[0066] The first movable pipette mount 202-1 and the second movable pipette mount 202-2 can further include positioning pins to help a user properly orient the first pipette 104-1 and the second pipette 104-2, and / or the third pipette 702, relative to the first movable pipette mount 202-1 and the second movable pipette mount 202-2. In one example, the first movable pipette mount 202-1 can include a first positioning pin 206-1 and a second positioning pin 206-2. Similarly, in one example, the second movable pipette mount 202-2 can include a third positioning pin 206-3 and a fourth positioning pin 206-4 (collectively referred to herein as positioning pins 206). Although four positioning pins 206 are depicted in the figures, any number of positioning pins 206 can be included on the first movable pipette mount 202-1 and the second movable pipette mount 202-2.

[0067] The positioning pins 206 can interface with corresponding positioning pin apertures, examples of which are depicted in conjunction with Figure 10The first pipette 104-1 depicted herein is described. For example, the first pipette 104-1 may include a first locating pin orifice 1014-1 and a second locating pin orifice 1014-2 (collectively referred to herein as locating pin orifice 1014), which correspond to a first locating pin 206-1 and a second locating pin 206-2, or a third locating pin 206-3 and a fourth locating pin 206-4, depending on which of the first pipette 104-1 is coupled to a first movable pipette mount 202-1 and a second movable pipette mount 202-2. The second pipette 104-2 and the third pipette 702 may include locating pin orifices as described herein in conjunction with the first pipette 104-1. In addition, in one example, the fourth pipette 802 may not include a locating pin orifice similar to those included in the first pipette 104-1, the second pipette 104-2 and the third pipette 702, but may include other features as described herein due to its different shape parameters, size and weight.

[0068] like Figure 10 As depicted, the first pipette 104-1 is shown to have a first locating pin 206-1, which is contained in a first locating pin orifice 1014-1, to illustrate the interaction between the locating pin 206 and the locating pin orifice 1014. Furthermore, Figure 10 The second locating pin orifice 1014-2 is depicted without the locating pin 206 such as the second locating pin 206-2.

[0069] In addition to the positioning pin 206 and the positioning pin orifice 1014, and to further assist the user in properly coupling the first pipette 104-1, the second pipette 104-2, the third pipette 702 and the fourth pipette 802 to the movable stage 102, the movable stage 102 and the pipettes may include alignment indicators, which are included on the first movable pipette mount 202-1 and the second movable pipette mount 202-2. In one example, the alignment indicator may include horizontal alignment indicators 208-1, 208-2, 208-3, 208-4, 208-5, 208-6, and 208-7 (collectively referred to herein as horizontal alignment indicator 208) to help the user align the pipette with the first movable pipette mount 202-1 and the second movable pipette mount 202-2 along the horizontal axis (e.g., the x-axis) of the movable stage 102, the first movable pipette mount 202-1, and the second movable pipette mount 202-2. The horizontal alignment indicator 208 can be positioned along the z-axis of the first removable pipette mount 202-1 and the second removable pipette mount 202-2, such that when the first pipette 104-1, the second pipette 104-2, the third pipette 702, and / or the fourth pipette 802 are correctly aligned with the sides of the pipettes relative to the first removable pipette mount 202-1 and / or the second removable pipette mount 202-2, the horizontal alignment indicator 208 can be aligned with the sides of the pipettes. This allows the user to correctly identify the horizontal placement of the pipettes relative to the first and / or second removable pipette mounts when attempting to position the pipettes relative to the first and / or second removable pipette mounts 202-1 and / or the second removable pipette mount 202-2.

[0070] The alignment indicator may further include vertical alignment indicators 212-1, 212-2, 212-3, and 212-4 (collectively referred to herein as vertical alignment indicator 212) to further assist the user in properly coupling the first pipette 104-1, the second pipette 104-2, the third pipette 702, and the fourth pipette 802 to the movable stage 102. The vertical alignment indicator 212 may be placed next to or adjacent to the horizontal alignment indicator 208. The vertical alignment indicator 212 assists the user in aligning the pipettes with the first movable pipette mount 202-1 and the second movable pipette mount 202-2 along the vertical axis (e.g., the z-axis) of the movable stage 102, the first movable pipette mount 202-1, and the second movable pipette mount 202-2. The vertical alignment indicator 212 can be positioned along the x-axis of the first removable pipette mount 202-1 and the second removable pipette mount 202-2 such that when the first pipette 104-1, the second pipette 104-2, the third pipette 702, and / or the fourth pipette 802 are correctly aligned with the corresponding alignment indicator placed on the pipette, as described below. This allows the user to correctly identify the vertical placement of the pipette relative to the first removable pipette mount 202-1 and / or the second removable pipette mount 202-2 when attempting to position the pipette relative to the first removable pipette mount 202-1 and / or the second removable pipette mount 202-2.

[0071] In addition, as mentioned above, the corresponding alignment indicator can be placed on the pipette, which the user can use to align with the vertical alignment indicator 212. Figure 1 and Figures 7 to 10 Examples of pipette indicators 112-1, 112-2, 808, and 1018 are depicted. Pipette indicators 112-1, 112-2, 808, and 1018 can be placed on the side of the pipette so that they can be seen by the user next to the vertical alignment indicator 212 and are easily aligned with it. Furthermore, pipette indicators 112-1, 112-2, 808, and 1018 can be positioned approximately perpendicular to the edges of the first pipette 104-1, the second pipette 104-2, the third pipette 702, and the fourth pipette 802, allowing the user to visually align pipette indicators 112-1, 112-2, 808, and 1018 with the vertical alignment indicator 212.

[0072] In one example, pipette indicators 112-1, 112-2, 808, and 1018 can be vertically aligned with the first recess 108-1, the second recess 108-2, the third recess 110-1, the fourth recess 110-2, the fifth recess 706-1, the sixth recess 706-2, the seventh recess 806-1, the eighth recess 806-2, the ninth recess 806-3, and / or the tenth recess 806-4, so that the user knows that the tethering screw contained in the recess is aligned with the vertical alignment indicator 212 presented on the first movable pipette mount 202-1 and the second movable pipette mount 202-2.

[0073] Once the user aligns the pipette relative to the horizontal alignment indicator 208 and the vertical alignment indicator 212, the pipette is correctly positioned such that the locating pin 206 aligns with the locating pin orifice 1014, and the tethering screws 902 and 1002 align with the corresponding threaded recesses 210-1, 210-2, 210-3, and 210-4 (collectively referred to herein as threaded recesses 210). The threaded shanks 906 and 1006 of the tethering screws 902 and 1002 can engage in these threaded recesses. Furthermore, in this aligned state, the first electrical connector 204-1 and the second electrical connector 204-2 are aligned with and can be coupled to the pipette electrical connector 1016. In this way, the horizontal alignment indicator 208, the vertical alignment indicator 212, the locating pin 206, and the locating pin orifice 1014 help the user engage the pipette's tethering screws 902, 1002 with the first movable pipette mount 202-1 and the second movable pipette mount 202-2.

[0074] As described above, the first pipette 104-1, the second pipette 104-2, the third pipette 702, and the fourth pipette 802 have different shape parameters or dimensions occupying a portion of the movable stage 102. The first pipette 104-1, the second pipette 104-2, and the third pipette 702 have shape parameters occupying half of the front portion of the movable stage 102, such that any two of the first pipette 104-1, the second pipette 104-2, and the third pipette 702 can be coupled to the movable stage 102 simultaneously. In contrast, the fourth pipette 802 may have a width approximately twice that of the first pipette 104-1, the second pipette 104-2, and the third pipette 702. Because the fourth pipette 802 is much wider, the movable stage 102 can accommodate only the fourth pipette 802, without accommodating other pipettes, including the other fourth pipettes 802 and any of the first pipette 104-1, the second pipette 104-2, and the third pipette 702. Furthermore, it is noted again here that the first movable pipette mount 202-1 coupled to the first half of the movable stage 102 and the second movable pipette mount 202-2 coupled to the second half of the movable stage 102 can move independently in the z-direction (e.g., vertically up and down along the z-axis) to allow the pipettes to dispense liquid solutions. However, in the case where the fourth pipette 802 is coupled to the movable stage 102, the movement of both the first movable pipette mount 202-1 and the second movable pipette mount 202-2 may not be advantageous, and instead, one of the first movable pipette mount 202-1 and the second movable pipette mount 202-2 may detach from the movable stage 102, such that the detached one of the first movable pipette mount 202-1 and the second movable pipette mount 202-2 may no longer be driven by the movable stage 102.

[0075] In view of the above, in order to accommodate the coupling of the fourth pipette 802 to the movable stage 102, for example, the second movable pipette mount 202-2 can be detached to allow at least a portion of the second movable pipette mount 202-2 to move freely or otherwise without being driven by the movable stage 102. For example, the second movable pipette mount 202-2 may include a mounting head 214 and a mounting base 216, which may be selectively coupled to the mounting head 214 via, for example, a mounting screw 218. The mounting screw 218 may be accessed via a mounting screw orifice 220 defined in a mounting bracket 222 coupled to the mounting head 214. The mounting screw 218 may be a tethered screw and may be held within the mounting bracket 222 and the mounting head 214 via a retaining ring 224. When the thread 228 of the mounting nut 302 disengages from the thread of the mounting nut 302 coupled to the mounting base 216, the biasing force of the mounting screw spring 226 can be used to force the mounting screw 218 upward in the z-direction and away from engagement with the mounting base 216. In this way, the mounting head 214 can be disengaged from the mounting base 216, as in, for example... Figures 3 to 6 , Figure 8 and Figure 9 As depicted in the illustration. In one example, the mounting nut 302 may include any device that serves as a bolt for mounting the screw 218 and is coupled to the mounting base 216, including, for example, a barrel nut, a connector bolt, a sleeve nut, or other types of nuts that may be coupled to the mounting base 216.

[0076] When the mounting head 214 is coupled to the mounting base 216, the mounting base 216 can enter an abutment position relative to the mounting head 214, and the biasing force of the mounting screw spring 226 can be overcome by pushing against the top side of the mounting screw 218 and using a tool to overcome the biasing force of the mounting screw spring 226. In this state, the tool can be rotated to engage the thread 228 of the mounting screw spring 226 with the mating thread of the mounting nut 302, thereby re-coupling the mounting head 214 to the mounting base 216, as in, for example... Figure 1 , Figure 2 , Figure 7 As depicted in the document. In this way, the mounting head 214 and the mounting base 216 can be selectively coupled and decoupled from each other.

[0077] To couple the fourth pipette 802 to the movable stage 102, the mounting head 214 can be separated from the mounting base 216, for example, in... Figures 3 to 6 , Figure 8 and Figure 9As depicted in [the text] and described herein. In this state, the mounting head 214 can remain engaged with the drive unit and will not fall along the track system or other system for this reason. However, in one example, once the mounting base 216 is separated from the mounting head 214, the mounting base 216 can fall freely in the z-direction along, for example, the track system or other system, with the first movable pipette mount 202-1 and the second movable pipette mount 202-2 coupled to the movable stage 102 via the track system or other system. This may occur because the mounting base 216 is not directly coupled to the drive unit as the mounting head 214.

[0078] In one example, the movable stage 102 may be able to detect when the mounting base 216 separates from the mounting head 214 and may relay information defining this state to the hardware and / or software of the liquid handling system. The liquid handling system may then suppress the sending of signals to the second movable pipette mount 202-2, causing the mounting head 214 to be unable to move in the z-direction or along the track system.

[0079] As the mounting base 216 detaches from the mounting head 214, the first movable pipette mount 202-1, which remains coupled to its drive system, can be coupled to the mounting base 216 of the second movable pipette mount 202-2. Figure 3 and Figure 4 In one example depicted, the first adapter 304 can be used. Figure 5 and Figure 6 In one example depicted in the document, a second adapter can be used.

[0080] refer to Figure 3 and Figure 4The first adapter 304 depicted may include a first lever 306-1 and a second lever 306-2, which can be used to align the mounting base 216 with and couple the mounting base 216 to the first movable pipette mounting base 202-1. The first movable pipette mounting base 202-1 and the mounting base 216 may include a first channel 230-1 defined in the top portion of the first movable pipette mounting base 202-1, a second channel 230-2 defined in the bottom portion of the first movable pipette mounting base 202-1, a third channel 230-3 defined in the top portion of the mounting base 216, and a fourth channel 230-4 defined in the bottom portion of the mounting base 216 (the first channel 230-1, the second channel 230-2, the third channel 230-3, and the fourth channel 230-4 are collectively referred to herein as channel 230). Channel 230 can be defined in the first removable pipette mount 202-1 and the mounting base 216 to create a space in which the first rod 306-1 and the second rod 306-2 can be disposed. Specifically, the first rod 306-1 can be disposed in the first channel 230-1 defined in the top portion of the first removable pipette mount 202-1 and the third channel 230-3 defined in the top portion of the mounting base 216, thereby bridging the first removable pipette mount 202-1 and the mounting base 216 in a first position. Similarly, the second rod 306-2 can be disposed in the second channel 230-2 defined in the bottom portion of the first removable pipette mount 202-1 and the fourth channel 230-4 defined in the bottom portion of the mounting base 216, thereby bridging the first removable pipette mount 202-1 and the mounting base 216 in a second position.

[0081] The first rod 306-1 and the second rod 306-2 may use multiple fastening devices, such as, for example, tethering screws housed within the first rod 306-1 and the second rod 306-2, coupled to the first movable pipette mount 202-1 and the mount base 216. Specifically, the first rod 306-1 and the second rod 306-2 may include tethering screw orifices 402-1, 402-2, 402-3, 402-4, 402-5, and 402-6 (collectively referred to herein as tethering screw orifice 402). Furthermore, as... Figure 2 As depicted, the tether screw holes 402 of the first rod 306-1 and the second rod 306-2 can be aligned with the corresponding pipette mount holes 232 to ensure that the first rod 306-1 and the second rod 306-2 are coupled to the first movable pipette mount 202-1 and the mounting base 216 in an aligned manner.

[0082] Furthermore, the first rod 306-1 and the second rod 306-2 may include tethering screws 404-1, 404-2, 404-3, 404-4, 404-5, and 404-6 (collectively referred to herein as tethering screws 404) for each tethering screw orifice. In the case of tethering screw orifices 402-3 and 402-6, the corresponding tethering screws 404-3 and 404-6 may include tethering screws protruding from the faces of the first rod 306-1 and the second rod 306-2. However, the tethering screw orifices 402-3 and 402-6, and the corresponding tethering screws 404-3 and 404-6 may include shape parameters as described in combination with another of the tethering screw orifice 402 and the corresponding tethering screw 404. By utilizing the tethering screw 404 and its engagement with the tethering screw orifice 402, the first rod 306-1 and the second rod 306-2 can be coupled to the channel 230.

[0083] As described above, the coupling of the first rod 306-1 and the second rod 306-2 with the mounting base 216 of the first and second movable pipette mounts 202-1 and 202-2 allows the fourth pipette 802 to be coupled to the movable stage 102. In one example, the fourth pipette 802 may be significantly larger and heavier than, for example, the first pipette 104-1 and the second pipette 104-2, and the third pipette 702. In one example, the fourth pipette 802 may include 96 pipette tips (e.g., a 96-channel pipette) and its weight, whether loaded with fluid or not, may be between 20 pounds and 50 pounds. However, the weight of the fourth pipette 802 can be any number of pounds. To support the weight and secure the fourth pipette 802 to the movable stage 102, the first rod 306-1 and the second rod 306-2 may further include a plurality of support posts 308-1, 308-2 (collectively referred to herein as support posts 308). Similar to locating pin 206, support post 308 can be connected to a corresponding support post orifice interface defined on the back side of fourth pipette 802. In one example, the support post orifice defined in fourth pipette 802 may include a snap-fit ​​mechanism such as a spring-loaded snap that moves about the head of support post 308 and is positioned within a relatively narrow portion of support post 308 when the biasing force of the spring is overcome. Figure 3 and Figure 4 The image depicts two support posts 308-1 and 308-2. However, additional support posts 308 may be included on other portions of the first post 306-1 and / or the second post 306-2.

[0084] Turning Figure 8 and Figure 9Once the fourth pipette 802 is coupled to the support post 308 of the first rod 306-1 and / or the second rod 306-2, the pipette tethering screws contained in the seventh recess 806-1, the eighth recess 806-2, the ninth recess 806-3, and the tenth recess 806-4 of the fourth pipette 802 can engage with the first rod 306-1 and / or the second rod 306-2. Specifically, the pipette tethering screws contained in the seventh recess 806-1, the eighth recess 806-2, the ninth recess 806-3, and the tenth recess 806-4 may include pipette tethering screws, such as... Figure 9 The tether screw 902 depicted and described above. The first rod 306-1 and the second rod 306-2 may include corresponding rod orifices 406-1, 406-2, 406-3, 406-4 (collectively referred to herein as rod orifices 406), and can be distinguished from the tether screw orifices 402 defined in the first rod 306-1 and the second rod 306-2 by excluding the corresponding tether screw 404. Furthermore, the rod orifice 406 may be aligned with one or more pipette mount orifices 232; specifically, with pipette mount orifices 232-2, 232-4, to allow for, for example Figure 9 The tethering screw 902 depicted extends through the rod orifice 406 and engages with the rod orifice 406 and / or pipette mount orifices 232-1, 232-4. In the case of rod orifices 406-3 and 406-4, the fourth pipette 802... Figure 9 The two lower tethering screws 902 depicted can engage with rod orifices 406-3 and 406-4, but not with pipette mount orifice 232. However, the manner in which the tethering screws 902 of the fourth pipette 802 engage with the pipette mount orifice 232 of the first rod 306-1, the second rod 306-2, and / or the first movable pipette mount 202-1 and the second movable pipette mount 202-2 can vary, and any manner in which the fourth pipette 802 is coupled to the movable stage 102 can vary.

[0085] Now for reference Figure 5 and Figure 6The second adapter 502 depicted may include a top rail 602, a first side rail 604, a bottom rail 606, and a second side rail 608. These rails can be used to align the mounting base 216 with and couple the mounting base 216 to the first movable pipette mounting base 202-1. Compared to the first adapter 304, which includes two separate components or elements (first rod 306-1 and second rod 306-2), the top rail 602, first side rail 604, bottom rail 606, and second side rail 608 can be formed as a single device. The second adapter 502 can be formed as a single element or device to make it easier for the user to store, locate, and install a single element or device, rather than two or more elements or devices.

[0086] As described above, the first removable pipette mount 202-1 and the mounting base 216 may include a first channel 230-1 defined in the top portion of the first removable pipette mount 202-1, a second channel 230-2 defined in the bottom portion of the first removable pipette mount 202-1, a third channel 230-3 defined in the top portion of the mounting base 216, and a fourth channel 230-4 defined in the bottom portion of the mounting base 216 (the first channel 230-1, the second channel 230-2, the third channel 230-3, and the fourth channel 230-4 are collectively referred to herein as channel 230). Channel 230 may be defined in the first removable pipette mount 202-1 and the mounting base 216 to create a space in which the top rail 602 and the bottom rail 606 of the second adapter 502 may be disposed. Specifically, the top track 602 can be positioned in a first channel 230-1 defined in the top portion of the first movable pipette mount 202-1 and a third channel 230-3 defined in the top portion of the mounting base 216, thereby bridging the first movable pipette mount 202-1 and the mounting base 216 in a first position. Similarly, the bottom track 606 can be positioned in a second channel 230-2 defined in the bottom portion of the first movable pipette mount 202-1 and a fourth channel 230-4 defined in the bottom portion of the mounting base 216, thereby bridging the first movable pipette mount 202-1 and the mounting base 216 in a second position. In many respects, Figure 5 and Figure 6 The functions and forms of the top rail 602 and bottom rail 606 of the second adapter 502 depicted herein can be related to Figure 3 and Figure 4The first lever 306-1 and the second lever 306-2 of the first adapter 304 depicted herein are similar in function and form to each other.

[0087] The second adapter 502 may use multiple fastening devices, such as, for example, tethering screws housed within the top rail 602 and bottom rail 606 of the second adapter 502, coupled to the first movable pipette mount 202-1 and mounting base 216. Specifically, the top rail 602 and bottom rail 606 may include, as described herein, Figure 3 and Figure 5 The described tether screw hole 402. Furthermore, as... Figure 2 As depicted, the tether screw hole 402 of the second adapter 502 can be aligned with the corresponding pipette mount hole 232 to ensure that the first rod 306-1 and the second rod 306-2 are coupled to the first movable pipette mount 202-1 and the mounting base 216 in an aligned manner.

[0088] Furthermore, the top rail 602 and bottom rail 606 of the second adapter 502 may include tether screws 404 for each tether screw hole. In the case of tether screw holes 402-3 and 402-6, the corresponding tether screws 404-3 and 404-6 may include tether screws protruding from the faces of the top rail 602 and bottom rail 606. However, tether screw holes 402-3 and 402-6, and the corresponding tether screws 404-3 and 404-6 may include shape parameters as depicted in conjunction with another of the tether screw holes 402 and the corresponding tether screws 404. By utilizing the tether screws 404 and their engagement with the tether screw holes 402, the top rail 602 and bottom rail 606 can be coupled to the channel 230.

[0089] As described above, the coupling of the second adapter 502 with the mounting base 216 of the first movable pipette mount 202-1 and the second movable pipette mount 202-2 allows the fourth pipette 802 to be coupled to the movable stage 102. As mentioned above, the fourth pipette 802 can be significantly larger and heavier than, for example, the first pipette 104-1, the second pipette 104-2, and the third pipette 702. Therefore, to be compatible with... Figure 3 and Figure 4 Similar to the first adapter 304, in order to support the weight and secure the fourth pipette 802 to the movable stage 102, the top rail 602 and bottom rail 606 may further include a plurality of support posts 308. In a manner similar to the locating pin 206, the support posts 308 may connect to corresponding support post orifice interfaces defined on the back of the fourth pipette 802.

[0090] Turn again Figure 8 and Figure 9The above description details the coupling of the fourth pipette 802 with the support posts 308 of the top rail 602 and bottom rail 606, and the use of pipette retaining screws included in the seventh recess 806-1, eighth recess 806-2, ninth recess 806-3, and tenth recess 806-4 of the fourth pipette 802. The top rail 602 and bottom rail 606 of the second adapter 502 may include corresponding rod apertures 406, similar to the first rod 306-1 and second rod 306-2 of the first adapter 304. Furthermore, the rod apertures 406 may be aligned with one or more pipette mount apertures 232; specifically, with pipette mount apertures 232-2, 232-4, to allow for, for example… Figure 9 The tethering screw 902 depicted extends through the rod orifice 406 and engages with the rod orifice 406 and / or pipette mount orifices 232-2, 232-4. In the case of rod orifices 406-3 and 406-4, the fourth pipette 802... Figure 9 The two lower tethering screws 902 depicted can engage with rod orifices 406-3 and 406-4, but not with pipette mount orifice 232. However, the manner in which the tethering screws 902 of the fourth pipette 802 engage with the top rail 602, the bottom rail 606, and / or the pipette mount orifice 232 of the first movable pipette mount 202-1 and the second movable pipette mount 202-2 can vary, and any manner in which the fourth pipette 802 is coupled to the movable stage 102 can vary.

[0091] The second adapter 502 may include an orientation indicator 504. The orientation indicator 504 can be used to help the user correctly orient the second adapter 502 relative to the first and second removable pipette mounts 202-1 and 202-2 of the movable stage 102. Furthermore, although not depicted, the first lever 306-1 and / or the second lever 306-2 of the first adapter 304 may also include an orientation indicator 504 to assist the user in the same way.

[0092] Figure 11A computing system diagram is illustrated, illustrating a configuration of a liquid handling system 1100 that can be used to implement various aspects of the techniques disclosed herein. The liquid handling system 1100 may include a substrate 1102 or “motherboard,” which is a printed circuit board, and multiple components or devices may be connected to the substrate 1102 or “motherboard” via a system bus or other electrical communication path. In one example, one or more central processing units (“CPUs”) 1104 operate in conjunction with a chipset 1106. The CPU 1104 may be a standard programmable processor that performs the arithmetic and logical operations required for the operation of the liquid handling system 1100.

[0093] The CPU 1104 performs operations by manipulating switching elements to transition from one discrete physical state to another, distinguishing and altering these states. These switching elements may include electronic circuitry, such as flip-flops, that holds one of two binary states; and electronic circuitry, such as logic gates, that provides an output state based on a logical combination of the states of one or more other switching elements. These switching elements can be combined to create more complex logic circuitry, including registers, adder-subtractor units, arithmetic logic units, floating-point units, and so on.

[0094] Chipset 1106 provides an interface between CPU 1104 and the remaining components and devices on substrate 1102. Chipset 1106 may provide an interface with RAM 1108, which serves as the main memory in the liquid handling system 1100. Chipset 1106 may further provide an interface with a computer-readable storage medium, such as read-only memory (“ROM”) 1110 or non-volatile RAM (“NVRAM”), for storing basic routines that facilitate the startup of the liquid handling system 1100 and the transfer of information between various components and devices. ROM 1110 or NVRAM may also store other software components required for operating the liquid handling system 1100 according to the configuration described herein.

[0095] The liquid handling system 1100 can operate in a networked environment using logical connections to remote computing devices and computer systems via a network such as network 1130. Chipset 1106 may include functionality for providing network connectivity via a network interface controller (NIC) 1112, such as a Gigabit Ethernet adapter. NIC 1112 is capable of connecting the liquid handling system 1100 to other computing devices via network 1130. It should be understood that multiple NICs 1112 may exist in the liquid handling system 1100, connecting the computer to other types of networks and remote computer systems. The liquid handling system 1100 may be connected to an instruction device 1128. Instruction device 1128 may include any computing device other than the computing elements of the liquid handling system 1100, which can be used to provide instructions and / or program the liquid handling system 1100. In one example, instruction device 1128 may be included as "Software as a Service" (SaaS), where the product is provided as a service (e.g., as a subscription-based service) rather than as an artifact owned and maintained by the user.

[0096] Despite the combination Figure 11 The described components are depicted as being directly or indirectly connected via, for example, LAN 1130, but these components can be entirely contained within the liquid handling system 1100, or distributed across any number of separate devices and computing networks. For example, the instruction device 1128 can be located directly within the liquid handling system 1100, rather than as... Figure 11 It is connected via LAN 1130 as described.

[0097] The liquid handling system 1100 may include a storage device 1122, or may be electrically, mechanically, and / or communicatively connected to the storage device 1122, which provides non-volatile storage for the liquid handling system 1100. The storage device 1122 may store an operating system 1124, programs 1126, and data. The storage device 1122 may be connected to the liquid handling system 1100 via a storage controller 1114 connected to a chipset 1106. The storage device 1122 may consist of one or more physical storage units. The storage controller 1114 may interface with the physical storage units via a Serial Attached SCSI (“SAS”) interface, a Serial Advanced Technology Attachment (“SATA”) interface, a Fibre Channel (“FC”) interface, or other types of interfaces used for physical connection and data transfer between a computer and physical storage units.

[0098] The liquid handling system 1100 can store data on the storage device 1122 by transforming the physical state of the physical storage units to reflect the stored information. In the different embodiments described herein, the specific transformation of the physical state may depend on various factors. Examples of such factors may include, but are not limited to, the technology used to implement the physical storage units, whether the storage device 1122 is characterized as main memory or auxiliary memory, etc.

[0099] For example, the liquid handling system 1100 can send instructions via the storage controller 1114 to store information in the storage device 1122 to alter the magnetic properties of a specific location in a disk drive unit, the reflection or refraction properties of a specific location in an optical storage unit, or the electrical properties of a specific capacitor, transistor, or other discrete component in a solid-state storage unit. Other transformations of the physical medium are possible without departing from the scope and spirit of this description, wherein the foregoing examples are provided only for the convenience of this description. The liquid handling system 1100 can further read information from the storage device 1122 by detecting the physical state or characteristics of one or more specific locations within the physical storage unit.

[0100] In addition to the high-capacity storage device 1122 described above, the liquid processing system 1100 can access other computer-readable storage media to store and retrieve information, such as program modules, data structures, or other data. Those skilled in the art will understand that a computer-readable storage medium is any available medium that provides non-transitory storage of data and can be accessed by the liquid processing system 1100. In one example, operations performed by the liquid processing system 1100 and / or any components included therein can be supported by one or more devices similar to the liquid processing system 1100. In other words, some or all of the operations performed by the liquid processing system 1100 and / or any components included therein can be performed by one or more computing devices operating in a cloud-based layout.

[0101] By way of example and not limitation, computer-readable storage media can include volatile and non-volatile, removable and non-removable media implemented in any method or technology. Computer-readable storage media include, but are not limited to, RAM, ROM, erasable programmable ROM (“EPROM”), electrically erasable programmable ROM (“EEPROM”), flash memory or other solid-state memory technologies, compact disc ROM (“CD-ROM”), digital versatile optical disc (“DVD”), high-definition DVD (“HD-DVD”), Blu-ray disc (BLU-RAY) or other optical storage devices, magnetic tape cassettes, magnetic tape, disk storage devices or other magnetic storage devices, or any other medium that can be used to store desired information in a non-transitory manner.

[0102] As briefly mentioned above, storage device 1122 may store operating system 1124 for controlling the operation of liquid handling system 1100. According to one embodiment, operating system 1124 may include a LINUX operating system. According to another example, the operating system may include a WINDOWS® SERVER operating system from Microsoft Corporation, Redmond, Washington. According to yet another example, operating system 1124 may include a UNIX operating system or a variant thereof. It should be understood that other operating systems may also be used. Storage device 1122 may store other systems or applications and data used by liquid handling system 1100.

[0103] In one example, storage device 1122 or other computer-readable storage medium is encoded with computer-executable instructions that, when loaded into liquid handling system 1100, transform the computer from a general-purpose computing system into a special-purpose computer capable of implementing the embodiments described herein. As described above, these computer-executable instructions transform liquid handling system 1100 by specifying how CPU 1104 transitions between states. According to one example, liquid handling system 1100 can access a computer-readable storage medium storing computer-executable instructions that, when executed by liquid handling system 1100, perform the various processes described above. Liquid handling system 1100 may also include a computer-readable storage medium storing instructions for performing any other computer-implemented operations described herein.

[0104] The liquid handling system 1100 may also include one or more input / output controllers 1116 for receiving and processing input from a plurality of input devices, such as a user interface (UI) 1118, a keyboard, a mouse, a touchpad, a touchscreen, an electronic pen, or other types of input devices. Similarly, the input / output controllers 1116 may provide output to a display, such as the UI 1118, a computer monitor, a flat panel display, a digital projector, a printer, or other types of output devices. It should be understood that the liquid handling system 1100 may not include... Figure 11 All components shown may include Figure 11 Other components not explicitly shown in the document, or those that can be utilized with Figure 11 The architecture shown is completely different.

[0105] UI 1118 may include any user input and / or output devices as described above in conjunction with the devices associated with input / output controller 1116. UI 1118 may include, for example, haptic UIs (e.g., touch), visual UIs (e.g., vision), auditory UIs (e.g., sound), other types of UI devices, and combinations thereof. Users can utilize UI 1118 to receive information and instructions from liquid handling system 1100 regarding how to operate the liquid handling system 1100, including, for example, switching between pipettes 104-1, 104-2, 702, 802, which are selectively coupled to movable stage 102. Since this is one aspect of the systems and methods of the present invention, the process by which a user can interact with UI 1118 will now be described.

[0106] UI 1118 may display at least one selectable option, which the user can choose to initiate a series of prompts and / or verifications displayed on UI 1118 to switch between pipettes 104-1, 104-2, 702, and 802. In an example where the user attempts to switch between at least one of the first pipette 104-1, the second pipette 104-2, and the third pipette 702, and the fourth pipette 802, the user can select an option displayed on UI 1118, which initiates a series of prompts for instructions / commands and verifications to complete the switch. Liquid handling system 1100 may execute at least one of operating system 1124 and program 1126 to present the series of prompts on UI 1118. In addition, the input / output controller 1116 can help the UI 1118 to interface communicatively with the chipset 1106 and the storage device 1122 so that the operating system 1124 and the program 1126 can display instructions / commands and verifications associated with the prompt series on the UI 1118 and interpret any input from the user via the UI 1118.

[0107] In one example, the prompt series of instructions / commands and verifications may include text, images, videos, optional buttons, other instruction representations, and combinations thereof that can be displayed on UI 1118. Users can utilize these instruction representations to receive instructions from and provide input to the liquid handling system 1100. Therefore, any interaction between the user and the liquid handling system 1100 can be provided via UI 1118 in a manner in which the user can easily understand how to perform a switching process. In one example, the prompt series of instructions / commands and verifications may include prompts to the user to verify that the user has taken one or more actions. Such user verification allows the prompt series to continue to the next step or instruction / command. Furthermore, in one example, a redundant system may exist within the liquid handling system 1100 associated with UI 1118 in the form of one or more sensors 1132, included in an input / output controller 1116, capable of detecting one or more states associated with the liquid handling system 1100 and caused by user actions.

[0108] To begin the process of removing the first pipette 104-1, the second pipette 104-2, and / or the third pipette 702 and switching these devices for the fourth pipette 802, in one example, the user may be prompted via UI 1118 to disengage the pipette retaining screws 1002 of the first pipette 104-1, the second pipette 104-2, and / or the third pipette 702. By doing so, the first pipette 104-1, the second pipette 104-2, and / or the third pipette 702 can be separated from the first locating pin 206-1 and / or the second locating pin 206-2, and the first electrical connector 204-1 and / or the second electrical connector 204-2. The first pipette 104-1, the second pipette 104-2, and / or the third pipette 702 can then be set aside and stored.

[0109] UI 1118 may present a first verification, in which the user is required to verify that the first pipette 104-1, the second pipette 104-2, and / or the third pipette 702 have been successfully removed from the removable stage 102. The user can then select an optional option to indicate to the liquid handling system 1100 that the first pipette 104-1, the second pipette 104-2, and / or the third pipette 702 have been successfully removed from the removable stage 102. In one example, the liquid handling system 1100 may be able to detect whether one or more of the first pipette 104-1, the second pipette 104-2, and / or the third pipette 702 have been successfully removed from the removable stage 102 based on its ability to detect the first pipette 104-1, the second pipette 104-2, and / or the third pipette 702 via, for example, the first electrical connector 204-1 and / or the second electrical connector 204-2, or other components of the liquid handling system 1100. Similarly, the fourth pipette 802 can be detected when it is coupled or disengaged from the first electrical connector 204-1 and / or the second electrical connector 204-2 of the movable stage 102, as described in more detail below. In one example, the liquid handling system 1100 can request confirmation from the user via the UI 1118 regarding whether and / or when the first pipette 104-1, the second pipette 104-2, and / or the third pipette 702 have been successfully removed from the movable stage 102. When confirmation is provided by the user, the liquid handling system 1100 can provide additional instructions or prompts.

[0110] During this phase of the switching process, the liquid handling system 1100 can then display instructions to the user via the UI 1118 on how to detach the mounting base 216 of the second removable pipette mount 202-2 from the mounting head 214. Separation of the mounting base 216 of the second removable pipette mount 202-2 from the mounting head 214 is achieved by obtaining a tool that engages with the mounting screw 218 of the mounting head 214. The mounting screw 218 can then be separated from the mounting nut 302 of the mounting base 216 by, for example, disengaging the thread 228 of the mounting screw 218 from the mating thread of the mounting nut 302 coupled to the mounting base 216. This allows the mounting base 216 to be separated from the mounting head 214 of the second removable pipette mount 202-2. In one example, the liquid handling system 1100 may be able to detect the separation of the mounting base 216 from the mounting head 214, and / or the coupling of the mounting base 216 to the mounting head 214 via one or more sensors 1132, which are included as input / output controllers 1116 capable of detecting such separation or coupling. In one example, the liquid handling system 1100 may request confirmation from a user via a UI 1118 regarding whether and / or when the separation of the mounting base 216 from the mounting head 214, and / or the coupling of the mounting base 216 to the mounting head 214, has occurred. When confirmation is provided by the user, the liquid handling system 1100 may provide additional instructions or prompts. In this way, the UI 1118 may present a second verification, in which the user is required to verify that the mounting base 216 has been separated from the mounting head 214, or that the mounting base 216 has been coupled to the mounting head 214. The user can then select optional options to indicate whether the mounting base 216 and the mounting seat 214 are separated or whether the coupling between the mounting base 216 and the mounting seat 214 has been achieved.

[0111] Once the mounting base 216 is separated from the mounting head 214, the user can be instructed via UI 1118 to couple the first adapter 304 or the second adapter 502 to the channel 230 defined in the mounting base 216 of the first removable pipette mount 202-1 and the second removable pipette mount 202-2. This instruction may include details on how to use the tether screw 404 to couple the first adapter 304 or the second adapter 502 to the channel 230, and may also include instructions / commands on orienting the first adapter 304 or the second adapter 502 relative to the first removable pipette mount 202-1 and the mounting base 216 using, for example, an orientation indicator 504. In other steps described herein, the liquid handling system 1100 may be able to detect the installation of the first adapter 304 or the second adapter 502 via one or more sensors 1132, which are included as input / output controllers 1116 capable of detecting the coupling state of the first adapter 304 or the second adapter 502. In one example, the liquid handling system 1100 may request confirmation from a user via a UI 1118 regarding whether and / or when the coupling of the first adapter 304 or the second adapter 502 to the first removable pipette mount 202-1 and the mounting base 216 is achieved. When confirmation is provided by the user, the liquid handling system 1100 may provide additional instructions or prompts. In this way, the UI 1118 may present a third verification, in which the user is required to verify that the first adapter 304 or the second adapter 502 is coupled to the first removable pipette mount 202-1 and the mounting base 216. The user can then select an optional option to indicate that the coupling of the first adapter 304 or the second adapter 502 to the first removable pipette mount 202-1 and the mounting base 216 has been achieved.

[0112] Once the first adapter 304 or the second adapter 502 is coupled to the first movable pipette mount 202-1 and the mounting base 216, the fourth pipette 802 can then be coupled to the movable stage 102 via the first adapter 304 or the second adapter 502. The user can be instructed via the UI 1118 to couple the fourth pipette 802 to the movable stage 102. Such instructions may include, for example, using support posts 308 and / or locating pins 206 to initially couple the fourth pipette 802 to the movable stage 102. In one example, the liquid handling system 1100 may be able to detect the coupling of the fourth pipette 802 to the first adapter 304 or the second adapter 502 of the movable stage 102 via one or more sensors included as input / output controllers 1116, which are capable of detecting such coupling. For example, one or more sensors included as input / output controller 1116 may be associated with support post 308 and / or positioning pin 206 to detect coupling of the fourth pipette 802 to the movable stage 102. Furthermore, in one example, the liquid handling system 1100 may be able to detect coupling of the fourth pipette 802 to the first adapter 304 or second adapter 502 of the movable stage 102 by detecting the connection between the liquid handling system 1100 and the first electrical connector 204-1 and / or the second electrical connector 204-2. In one example, the liquid handling system 1100 may request confirmation from the user via UI 1118 regarding whether and / or when coupling of the fourth pipette 802 to the first adapter 304 or second adapter 502 is achieved. When confirmation is provided by the user, the liquid handling system 1100 may provide additional instructions or prompts. In this way, UI 1118 may present a fourth verification, in which the user is required to verify that the fourth pipette 802 is coupled to the first adapter 304 or second adapter 502. The user can then select an optional feature to indicate that the coupling of the fourth pipette 802 with the first adapter 304 or the second adapter 502 has been achieved.

[0113] Once the fourth pipette 802 is coupled to the movable stage 102 via the first adapter 304 or the second adapter 502, the user can be instructed via the UI 1118 to engage the pipette tether screw 902 of the fourth pipette 802 to secure the fourth pipette 802 to the first adapter 304 or the second adapter 502 and the movable stage 102. In one example, the liquid handling system 1100 may be able to detect engagement of the pipette tether screw 902 of the fourth pipette 802 via one or more sensors, which are included as input / output controllers 1116 capable of detecting such engagement. In one example, the liquid handling system 1100 can request confirmation from the user via the UI 1118 regarding whether and / or when engagement of the pipette tether screw 902 of the fourth pipette 802 has been achieved. When confirmation is provided by the user, the liquid handling system 1100 can provide additional instructions or prompts. In this way, UI 1118 can present a fifth verification, in which the user is required to verify that the pipette tether screw 902 of the fourth pipette 802 is engaged. The user can then select an optional option to indicate to the liquid handling system 1100 that the engagement of the pipette tether screw 902 of the fourth pipette 802 has been achieved.

[0114] The method described above can instruct the user to remove the first pipette 104-1, the second pipette 104-2, and / or the third pipette 702, and replace the first pipette 104-1, the second pipette 104-2, and / or the third pipette 702 with the fourth pipette 802. This can be done through interaction with the UI 1118 to receive instructions and prompts, as well as requests for confirmation via prompts, to confirm that the user's action has occurred. Converse or additional instructions and prompts can be presented to the user via the UI 1118 to remove the fourth pipette 802 and replace it with one or more of the first pipette 104-1, the second pipette 104-2, and the third pipette 702. In addition to the exemplary instructions and prompts described above, additional instructions and prompts may be presented to the user via UI 1118 to remove the first pipette 104-1, the second pipette 104-2, the third pipette 702 and / or the fourth pipette 802 and replace them with each other on the movable stage 102.

[0115] Turn again Figure 11The liquid handling system 1100 may further include liquid handling system hardware 1120. Liquid handling system hardware 1120 may include, for example, a movable stage 102, a first pipette 104-1, a second pipette 104-2, a third pipette 702, a fourth pipette 802, a first adapter 304, and a second adapter 502. Furthermore, liquid handling system hardware 1120 may include, for example, a platform, a cradle device coupled to the platform, and any type of module that can be coupled to the cradle device and is used to process the liquid dispensed by the liquid handling system 1100. Modules that can be coupled to the cradle device and are used to process the liquid dispensed by the liquid handling system 1100 may include, for example, a temperature platform, a thermal oscillator, a thermal circulator, a heating device, a cooling device, a vacuum pump, a centrifuge, a liquid processor, a tube handling device, a sealing device, an opening device, a magnetic device, other modules, and combinations thereof. In addition, the liquid handling system hardware 1120 may include the housing of the liquid handling system 1100 and any other components of the liquid handling system 1100.

[0116] Figure 12 Examples based on the principles described herein are illustrated. Figure 11 The liquid handling system 1100. As mentioned above, the liquid handling system 1100 may further include liquid handling system hardware 1120. Figure 12 Some of these components are depicted. For example, the liquid handling system 1100 may include a housing 1202. The housing 1202 may include one or more sides or walls, and as shown in the image. Figure 12 As depicted, the housing may include a top side, four vertically positioned sidewalls, and a bottom side, which are coupled to each other to form a generally box-shaped architecture to house and accommodate multiple other liquid handling system hardware 1120. In one example, one or more of the top side, sidewalls, and bottom side may include transparent portions such as windows to allow a user to observe the interior portions of the housing 1202.

[0117] The movable stage 102 may be housed within the housing 1202. The movable stage 102 may be mechanically coupled to an x-axis movable truss 1210, which allows the movable stage 102 to move in the x-direction. Furthermore, the movable stage 102 may be mechanically coupled to a first y-axis movable truss 1212-1 and a second y-axis movable truss 1212-2, which allow the movable stage 102 to move in the y-direction. The x-axis movable truss 1210, the first y-axis movable truss 1212-1, and the second y-axis movable truss 1212-2 may be driven by one or more motors, which may be actuated by commands received from the command device 1128 and any element within the base plate 1102. Commands to actuate the motors may move the movable stage 102 to a digitally addressable position within the housing 1202.

[0118] The housing 1202 may further accommodate a platform 1204. The platform 1204 may be positioned at the bottom of the housing 1202 and may hold one or more bracket devices 1206. The bracket devices 1206 may be removably or selectively coupled to the platform 1204 and may be used to hold one or more modules 1208 that may be coupled to the bracket devices 1206 and used to process liquids dispensed by the liquid handling system 1100. As mentioned above, modules 1208 may include, for example, temperature platforms, thermal oscillators, thermal circulators, heating devices, cooling devices, vacuum pumps, centrifuges, liquid processors, tube handling devices, sealing devices, opening devices, magnetic devices, other modules, and combinations thereof. Combined with commands for actuating motors associated with the x-axis movable truss 1210 and the first y-axis movable truss 1212-1 and the second y-axis movable truss 1212-2, these commands can move the movable stage 102 to a digitally addressable location within the housing 1202, including a region or portion of module 1208 or a location on that module, such that the first pipette 104-1, the second pipette 104-2, the third pipette 702, and the fourth pipette 802 can dispense fluid onto or into module 1208.

[0119] like Figure 12 As depicted, the liquid handling system 1100 may include a UI 1118. In one example and as shown... Figure 12As depicted herein, UI 1118 may be a touchscreen capable of detecting touch input from a user, and includes both an input device (touch panel) and an output device (visual display), wherein the touch panel is stacked on top of the electronic visual display. The instructions and prompts described herein may be presented to the user of the liquid handling system 1100 via this or another UI 1118. UI 1118 may be communicatively coupled to any element within instruction device 1128 and / or substrate 1102. This allows any element within instruction device 1128 and / or substrate 1102 to present the instructions and prompts described herein via UI 1118, and allows the user to input information via the interactive elements of UI 1118. Although depicted and described as a touchscreen, UI 1118 may include any input and output devices, such as, for example, a display device, printer, audio speaker, haptic device, head-up display, keyboard, mouse, touchpad, trackpad, accelerometer, gyroscope, proximity sensor, thermometer, virtual reality system, augmented reality system, joystick, gamepad, paddle, camera, microphone, other input and / or output devices, and combinations thereof. Furthermore, in one example, UI 118 may not be directly coupled to the liquid handling system 100 and may instead be associated with a separate computing device that is directly or indirectly coupled to the liquid handling system 100, such as, for example, in conjunction with... Figure 14 The computing system 1400 and / or instruction device 1428 are depicted and described.

[0120] Combination Figures 1 to 12When a user desires to switch between one or more of the first pipette 104-1, second pipette 104-2, third pipette 702, and / or fourth pipette 802, the user can interact with the UI 1118 to indicate to the liquid handling system 1100 that such a change is desired. Once the liquid handling system 1100 receives input from the user indicating a desire to switch between one or more of the first pipette 104-1, second pipette 104-2, third pipette 702, and / or fourth pipette 802, the liquid handling system 1100 can move the movable stage 102 to a position along the x-axis movable truss 1210 and to the front of the liquid handling system 1100 via the first y-axis movable truss 1212-1 and the second y-axis movable truss 1212-2, which allows easy access to the movable stage 102. For example, the liquid handling system 1100 can move the movable stage 102 to its leftmost position along the x-axis movable truss 1210 and to the foremost part of the liquid handling system 1100 via the first y-axis movable truss 1212-1 and the second y-axis movable truss 1212-2, allowing the user to access the movable stage 102 without having to reach the interior of the liquid handling system 1100, or reducing the distance the user might otherwise have to reach. Furthermore, in one example, the liquid handling system 1100 can move the movable stage 102 downwards in the z-direction, away from the top portion of the housing 1202, and allow the user easier access to the entire height of the movable stage 102. In one example, this position of the movable stage 102 within the liquid handling system 1100 can be referred to as the homeposition. In addition, in one example, a user can instruct the liquid handling system 1100 to move the movable stage 102 to its original position based on user input at UI 1118, which may include, for example, selecting an “original” button corresponding to the desired move of the movable stage 102 to its original position.

[0121] As described above, the hardware and software of the liquid handling system 1100 can identify the type of pipettes coupled to the movable stage 102, when these pipettes have been removed from the movable stage 102, and which additional or new pipettes have subsequently been coupled to the movable stage 102, including a first pipette 104-1, a second pipette 104-2, a third pipette 702 and / or a fourth pipette 802, or other devices such as gripper devices.

[0122] In one example, a user could utilize the process described herein to attach desired tools, such as the first pipette 104-1, the second pipette 104-2, the third pipette 702, and / or the fourth pipette 802, or other devices, such as gripper devices. However, in one example, the liquid handling system 1100 could present instructions to the user, based on a protocol that the user may have entered, regarding which of a plurality of tools will be attached to the movable stage 102. This protocol defines a specific liquid handling procedure that the liquid handling system 1100 has been instructed to perform. For example, the first part of the liquid handling procedure might require the use of a gripper device to transfer certain objects within the liquid handling system 1100, and the liquid handling system 1100 could instruct the user, after using the gripper device, to then remove the gripper device and attach one of the pipettes to the movable stage 102, so that the liquid handling system 1100 performs a second part of the liquid handling procedure, which includes, for example, the dispensing of liquid.

[0123] Figure 13 A perspective view of a movable stage assembly 1300, including a movable stage 102 and a gripper device 1302, illustrating an example of the principles described herein. Figure 14 A first perspective exploded view of a movable stage assembly 1300, including a movable stage 102 and a gripper device 1302, illustrating an example of the principles described herein. Figure 15 A second perspective exploded view illustrates an example of a movable stage assembly 1300, including a movable stage 102 and a gripper device 1302, based on the principles described herein. According to the example, the gripper device 1302 can be used as a robotic material handling device that provides various positions for placing, moving, repositioning, and removing containers or other components onto the platform 1204 of the liquid handling system 1100. The gripper device 1302 can be connected to the movable stage 102, such as... Figures 1 to 9 As illustrated herein, or can be operated independently of the movable stage 104 by moving along the x-axis movable truss 1210 in the same manner as the movable stage 102, as described herein.

[0124] The gripper device 1302 may include a gripper gantry 1304 from which a pair of gripper arms, including a first gripper arm 1306-1 and a second gripper arm 1306-2 (collectively referred to herein as gripper arm 1306), may be suspended. A first gripper claw 1308-1 and a second gripper claw 1308-2 (collectively referred to herein as gripper claw 1308) may be fixed to the lower end of the gripper arm 1306. A gripper claw pad 1312 may be disposed on the inner surface of the gripper claw 1308 to assist the gripper claw 1308 in gripping a container or device. In one example, the gripper pad 1312 may have a relatively higher coefficient of friction than any item that the gripper claw 1308 and / or gripper device 1302 can use to grip and / or carry, to ensure that the item is firmly captured or gripped when captured by the gripper claw device 1302. In one example, control circuitry in the gripper device 1302 (e.g., in the gripper frame 1304 or in the gripper arm 1306) may be programmed or otherwise commanded to move a container or device around the interior of the liquid handling system 1100 by squeezing (e.g., gripping) the gripper arm 1306 together to capture the container or device. In one example, the gripper claw 1308 and the associated gripper pad 1312 may be squeezed together via the movement of the gripper arm 1306 to capture the container or device. After the container or device has been placed in the desired location within the liquid handling system 1100, the container or device can be released at the given location by removing the gripper arm 1306.

[0125] Still referencing Figures 13 to 15 The gripper device 1302 can be coupled to the movable stage 102 in a similar manner to how the first pipette 104-1, the second pipette 104-2, the third pipette 702, and the fourth pipette 802 are coupled to the movable stage 102. The movable stage 102 may include a gripper mount 1402, which can be used as a connection point to the gripper device 1302. In one example, the gripper mount 1402 may be positioned on the side of the movable stage 102, with the first movable pipette mount 202-1 and / or the second movable pipette mount 202-2 not positioned on this side, such that the gripper device 1302 can be coupled to the movable stage 102, while the first pipette 104-1, the second pipette 104-2, the third pipette 702, and / or the fourth pipette 802 can also be coupled to the movable stage 102 simultaneously.

[0126] The gripper mount 1402 formed on the movable stage 102 may include at least one threaded opening, such as a first threaded opening 1404-1 and a second threaded opening 1404-2 (collectively referred to herein as threaded opening 1404) formed on the gripper mount 1402, to receive corresponding tethering screws coupled to the gripper device 1302, such as a first tethering screw 1410-1 and a second tethering screw 1410-2 (collectively referred to herein as tethering screw 1410). Furthermore, the gripper mounting base 1402 formed on the movable stage 102 may also include at least one locating pin orifice, such as a first locating pin orifice 1406-1 and a second locating pin orifice 1406-2 (collectively referred to herein as locating pin orifice 1406) defined in the gripper mounting base 1402, to receive corresponding locating pins coupled to the gripper device 1302, such as a first locating pin 1412-1 and a second locating pin 1412-2 (collectively referred to herein as locating pin 1412).

[0127] Furthermore, the gripper mount 1402 formed on the movable stage 102 may include a gripper mount electrical connector 1408, which is coupled to the gripper mount 1402 to electrically interface with a corresponding gripper electrical connector 1414 coupled to the gripper device 1302. In one example and as shown... Figures 13 to 15 As depicted, the gripper mount electrical connector 1408 may include an electrical connector having a female form factor, and the gripper electrical connector 1414 coupled to the gripper device 1302 may include a mating electrical connector having a male form factor. However, the mating female and male connectors may be positioned relative to each other on the gripper device 1302 or on the gripper mount 1402 formed on the movable stage 102.

[0128] In one example, the female electrical connectors associated with the first electrical connector 204-1, the second electrical connector 204-2, the pipette electrical connector 1016, the gripper mount electrical connector 1408, and / or the gripper electrical connector 1414 may include spring-biased electrical contacts to allow for a certain amount of placement error between the mating female and male electrical connectors. In one example, the female electrical connector may include 1674231-1, a DC jack connector developed and distributed by TE Connectivity, board-to-board, 10-pin, 0.098-inch (in.) (2.5 mm) centerline type, socket type, 30-volt DC (VDC), vertical, printed circuit board, power and signal female connector. In one example, the female electrical connector may include 1123688-7, a DC jack connector developed and distributed by TE Connectivity, board-to-board, 10-pin, 0.098-inch (2.5 mm) centerline type, receptacle type, 30 VDC, vertical, printed circuit board, power and signal female connector. In another example, the female electrical connector may include 1-1473776-7 DC, a jack connector developed and distributed by TE Connectivity, board-to-board, 10-pin, 0.098-inch (2.5 mm) centerline type, receptacle type, 30 VDC, vertical, printed circuit board, power and signal female connector.

[0129] In one example, the male electrical connector associated with the first electrical connector 204-1, the second electrical connector 204-2, the pipette electrical connector 1016, the gripper mount electrical connector 1408, and / or the gripper electrical connector 1414 may include multiple blades that can electrically and mechanically interface with and engage with the spring-biased electrical contacts of the female connector. In one example, the male electrical connector may include the 1123738-7 DC jack connector, board-to-board, 10-pin, 0.098-inch (2.5 mm) centerline, plug, 30 VDC, right-angle, printed circuit board (PCB) type, power and signal male connector developed and distributed by TE Connectivity. In one example, a male electrical connector may include the 1123684-7 DC jack connector, board-to-board, 10-pin, 0.098-inch (2.5 mm) centerline, plug, 30 VDC, right-angle type, printed circuit board, power and signal male connector developed and distributed by TE Connectivity.

[0130] Once the gripper device 1302 is mechanically and electrically coupled to the gripper mount 1402 formed on the movable stage 102, the movable stage 102 and associated control devices, such as the liquid handling system 1100, the command device 1128 and other command devices described herein, can be used to control the gripper device 1302.

[0131] Exemplary terms

[0132] A: A movable stage assembly comprising a movable stage; a threaded orifice defined in the movable stage; and an electrical connector coupled to the movable stage.

[0133] B: According to the movable stage assembly described in paragraph A, the movable stage assembly further includes a tool coupled to the movable stage.

[0134] C: A movable stage assembly according to any one of paragraphs A to B, wherein the tool includes a pipette or gripper device.

[0135] D: According to any one of paragraphs A to C, the movable stage assembly further includes a movable pipette mount coupled to the movable stage and movable along the length of the movable stage, the movable pipette mount for mounting the pipette to the movable stage, wherein: the threaded orifice is defined in the movable pipette mount, and the pipette includes a mating tethering fastener for engaging the threaded orifice.

[0136] E: The movable stage assembly according to any one of paragraphs A to D, the movable stage assembly further comprising a movable pipette mount coupled to the movable stage and movable along the length of the movable stage, the movable pipette mount for mounting the pipette to the movable stage, wherein: the electrical connector includes a first electrical connector coupled to the movable pipette mount of the movable stage, and the pipette includes a second electrical connector that is mateably engaged with the first electrical connector.

[0137] F: The movable stage assembly according to any one of paragraphs A to E, the movable stage assembly further comprising a movable pipette mount coupled to the movable stage and movable along the length of the movable stage, the movable pipette mount for mounting the pipette to the movable stage; and a locating pin coupled to the movable stage and protruding from the movable stage, wherein the locating pin is coupled to the movable stage of the movable stage and protruding from the movable stage of the movable stage, the locating pin being configured to engage a locating pin orifice defined in the pipette.

[0138] G: The movable stage assembly according to any one of paragraphs A to F, the movable stage assembly further comprising a gripper mount formed on the movable stage for mounting the gripper device to the movable stage, the gripper mount comprising: a threaded orifice defined in the gripper mount formed on the movable stage; an electrical connector coupled to the gripper mount formed on the movable stage; and a locating pin orifice defined in the gripper mount formed on the movable stage.

[0139] H: A movable stage assembly according to any one of paragraphs A to G, wherein the positioning pin orifice is configured to receive a positioning pin, the positioning pin being coupled to the gripper device and protruding from the gripper device.

[0140] I: The movable stage assembly according to any one of paragraphs A to H further includes an alignment indicator defined on the movable stage for visually aligning the tool with the movable stage.

[0141] J: The movable stage assembly according to any one of paragraphs A to I, wherein the alignment indicator includes a horizontal alignment indicator and a vertical alignment indicator.

[0142] K: A tool mounting system comprising: a threaded orifice defined on a movable stage for mechanically coupling a tool to the movable stage, the tool including a mating fastener for engaging with the threaded orifice; a first electrical connector coupled to the movable stage for electrically coupling the tool to the movable stage, the tool including a second electrical connector for mating with the first electrical connector; and a locating pin system for aligning the tool with the movable stage.

[0143] L: The tool installation system according to paragraph K, wherein the tool includes a pipette or gripper device.

[0144] M: A tool mounting system according to any one of paragraphs K to L, wherein the positioning pin system comprises: a positioning pin coupled to and protruding from the movable stage; and a positioning pin orifice defined in the pipette, the positioning pin being configured to engage the positioning pin orifice defined in the pipette to align the pipette relative to the movable stage.

[0145] N: A tool mounting system according to any one of paragraphs K to M, wherein the locating pin system comprises: a locating pin coupled to and protruding from the gripper device; and a locating pin orifice defined in the movable stage, the locating pin being configured to engage with the locating pin orifice defined in the movable stage to align the gripper device relative to the movable stage.

[0146] O: A tool mounting system according to any one of paragraphs K to N, wherein the locating pin system includes a gripper mount formed on the movable stage for mounting the gripper device to the movable stage, the gripper mount including: the threaded orifice defined in the gripper mount formed on the movable stage; and a first electrical connector coupled to the gripper mount formed on the movable stage and capable of engaging with a second electrical connector formed on the gripper device.

[0147] P: The tool mounting system according to any one of paragraphs K to O, the tool mounting system further includes an alignment indicator defined on the movable stage for visually aligning the tool with the movable stage.

[0148] Q: The tool installation system according to any one of paragraphs K to P, wherein the alignment indicator includes a horizontal alignment indicator and a vertical alignment indicator.

[0149] R: A tool mounting system according to any one of paragraphs K to Q, wherein the mating fastener includes a tether screw that is secured within the tool.

[0150] S: A tool mounting system according to any one of paragraphs K to R, wherein the first electrical connector or the second electrical connector includes spring-biased electrical contacts.

[0151] T: Tool installation system according to any one of paragraphs K to S, wherein the first electrical connector or the second electrical connector includes a power connection and a communication signal connection.

[0152] in conclusion

[0153] The examples described herein provide a liquid handling system that offers an apparatus by which a user can easily switch from a first pipette shape parameter to a second pipette shape parameter without requiring a professional operator, service provider, or technician to perform such a switch. This switching includes switching between a single-channel pipette, an eight-channel pipette, a 64-channel pipette, or other pipette shape parameters.

[0154] While the systems and methods of the present invention have been described with respect to specific examples, it should be understood that the scope of the systems and methods of the present invention is not limited to these specific examples. Since other modifications and variations made to adapt to specific operational requirements and environments will be readily apparent to those skilled in the art, the systems and methods of the present invention are not to be considered limited to the examples chosen for the purposes of disclosure, and encompass all changes and modifications that do not constitute a departure from the true spirit and scope of the systems and methods of the present invention.

[0155] Although this application describes examples with specific structural features and / or methodological actions, it should be understood that the claims are not necessarily limited to the specific features or actions described. Rather, the specific features and actions are merely illustrative examples of some examples falling within the scope of the claims of this application.

Claims

1. A movable stage assembly, the movable stage assembly comprising: a movable stage; a threaded aperture defined in the movable stage; and an electrical connector coupled to the movable stage.

2. The movable stage assembly of claim 1, further comprising a tool coupled to the movable stage.

3. The movable stage assembly of claim 2, wherein the tool comprises a pipette or a gripper device.

4. The movable stage assembly of claim 3, further comprising a movable pipette mount coupled to the movable stage and movable along a length of the movable stage, the movable pipette mount for mounting the pipette to the movable stage, wherein: the threaded aperture is defined in the movable pipette mount, and the pipette comprises a mating tethered fastener for engaging with the threaded aperture.

5. The movable stage assembly of claim 3, further comprising a movable pipette mount coupled to the movable stage and movable along a length of the movable stage, the movable pipette mount for mounting the pipette to the movable stage, wherein: the electrical connector comprises a first electrical connector coupled to the movable pipette mount of the movable stage, and the pipette comprises a second electrical connector matablely engageable with the first electrical connector.

6. The movable stage assembly of claim 3, further comprising: a movable pipette mount coupled to the movable stage and movable along a length of the movable stage, the movable pipette mount for mounting the pipette to the movable stage; and a locating pin coupled to the movable stage and protruding therefrom, wherein the locating pin is coupled to and protrudes from the movable pipette mount of the movable stage, the locating pin configured to engage with a locating pin aperture defined in the pipette.

7. The movable stage assembly of claim 3, further comprising a gripper mount formed on the movable stage for mounting the gripper device to the movable stage, the gripper mount comprising: the threaded aperture defined in the gripper mount formed on the movable stage; the electrical connector coupled to the gripper mount formed on the movable stage; and a locating pin aperture defined in the gripper mount formed on the movable stage. ​ ​ ​ 8. The movable stage assembly of claim 7, wherein the positioning pin aperture is configured to receive a positioning pin coupled to and protruding from the grabber device.

9. The movable stage assembly of claim 1, further comprising an alignment indicator defined on the movable stage for visually aligning a tool with the movable stage.

10. The movable stage assembly of claim 9, wherein the alignment indicator comprises a horizontal alignment indicator and a vertical alignment indicator.

11. A tool mounting system, comprising: a threaded aperture defined in a movable stage for mechanically coupling a tool to the movable stage, the tool comprising a mating fastener for engaging with the threaded aperture; a first electrical connector coupled to the movable stage for electrically coupling the tool to the movable stage, the tool comprising a second electrical connector matablely engageable with the first electrical connector; and a positioning pin system for aligning the tool with the movable stage.

12. The tool mounting system of claim 11, wherein the tool comprises a pipette or a grabber device.

13. The tool mounting system of claim 12, wherein the positioning pin system comprises: a positioning pin coupled to and protruding from the movable stage; and a positioning pin aperture defined in the pipette, the positioning pin configured to engage with the positioning pin aperture defined in the pipette to align the pipette relative to the movable stage.

14. The tool mounting system of claim 12, wherein the positioning pin system comprises: a positioning pin coupled to and protruding from the grabber device; and a positioning pin aperture defined in the movable stage, the positioning pin configured to engage with the positioning pin aperture defined in the movable stage to align the grabber device relative to the movable stage.

15. The tool mounting system of claim 12, wherein the positioning pin system comprises a grabber mount formed on the movable stage for mounting the grabber device to the movable stage, the grabber mount comprising: the threaded aperture defined in the grabber mount formed on the movable stage; and the first electrical connector coupled to the grabber mount formed on the movable stage matablely engageable with the second electrical connector formed on the grabber device. ​ ​ ​ ​ 16. The tool mounting system of claim 11, further comprising an alignment indicator defined on the movable stage for visually aligning the tool with the movable stage.

17. The tool mounting system of claim 16, wherein the alignment indicator comprises a horizontal alignment indicator and a vertical alignment indicator.

18. The tool mounting system of claim 11, wherein the mating fastener comprises a captive screw secured within the tool.

19. The tool mounting system of claim 11, wherein the first electrical connector or the second electrical connector comprises spring-biased electrical contacts.

20. The tool mounting system of claim 11, wherein the first electrical connector or the second electrical connector comprises a power connection and a communication signal connection.

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