Chewing gum based on composite stimulation as well as preparation method and application of chewing gum

Abstract

The invention discloses chewing gum based on composite stimulation as well as a preparation method and application of the chewing gum. Comprising the following raw material components in parts by weight: 0.09 to 0.105 part of 1, 8-cineole, 40 to 45 parts of gum base, 25 to 35 parts of D-mannitol, 8 to 15 parts of erythritol, 12 to 18 parts of purified water, 1 to 2 parts of caprylic / capric triglyceride, 0.3 to 0.8 part of soya bean lecithin, 0.2 to 0.4 part of Arabic gum and 0.05 to 0.1 part of carnauba wax. By organically combining composite stimulation with computerized task training, the limitation that a traditional nerve stimulation technology needs professionals and equipment is avoided, and work memory training is safe, effective and easy and convenient to operate. The device is especially suitable for daily training of people needing cognition improvement, such as people with high mental load and people with hypomnesis.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of high-intensity mental work, and particularly relates to a chewing gum based on composite stimulation and a preparation method and application thereof. BACKGROUND

[0002] Olfactory stimulation has been proven to affect brain activity. Lavender, orange flower, etc. have a calming effect, while rosemary, mint, etc. can enhance alertness and attention. The main active ingredient of rosemary essential oil, 1,8-cineole, is a monoterpene compound closely related to cognitive function regulation. Studies have shown that 1,8-cineole has cognitive enhancement effects, can improve attention, and may delay the progression of neurodegenerative diseases by regulating acetylcholine metabolism, and shows good effects in improving cognitive dysfunction in patients with Alzheimer's disease and vascular dementia. Chewing is similar to a kind of exercise, which can enhance cognitive function by promoting brain blood circulation, activating the cerebral cortex (especially the prefrontal cortex), and enhancing neuronal connections.

[0003] In the field of cognitive science, working memory enhancement has always been a research hotspot. Existing methods mainly include non-invasive neural stimulation technology and working memory training. Although working memory training can improve the cognitive function of people of all ages, it has problems such as long training period (usually 1-4 weeks of continuous training) and insignificant effect. Although non-invasive neural stimulation technology (such as transcranial electrical stimulation and transcranial magnetic stimulation) has certain effects, it is limited by high cost and complex operation. Therefore, it is of great significance to develop a safe, simple and suitable working memory enhancement method for daily application. SUMMARY

[0004] The purpose of the present application is to provide a chewing gum for promoting the rapid recovery of cognitive fatigue and a preparation method thereof.

[0005] A chewing gum based on composite stimulation comprises the following raw material components in parts by weight: 1,8-cineole 0.09-0.105 parts, gum base 40-45 parts, D-mannitol 25-35 parts, erythritol 8-15 parts, purified water 12-18 parts, caprylic capric glycerin 1-2 parts, soy lecithin 0.3-0.8 parts, gum arabic 0.2-0.4 parts, and carnauba wax 0.05-0.1 parts.

[0006] The preparation method of the chewing gum based on composite stimulation is carried out according to the following steps:

[0007] (1) Chewing gum adjuvant preparation: D-mannitol, erythritol and purified water were added to a reaction vessel, and stirred at 200 rpm-400 rpm for 8 min-12 min under the condition of 50 °C-55 °C oil bath heating, then gum arabic and carnauba wax were added in turn, and the stirring was continued for 10 min-20 min to form a homogeneous emulsion system;

[0008] (2) Gum base pretreatment: The gum base was placed in a 50 °C-55 °C oil bath pot and softened for 1 h-25 h, and stirred every 20 min-40 min during the process. The softened gum base was transferred to a 48 °C-50 °C constant temperature oven;

[0009] (3) Active ingredient pretreatment: 1,8-cineole was mixed with capryl capryl capryl glycerol ester at room temperature, and a stable microemulsion system was formed by using a high-pressure homogenizer at 40 MPa-80 MPa pressure for 2-4 cycles;

[0010] (4) The gum base pretreated in step (2) was placed in an oil bath at 45 °C-55 °C, and stirred at 45 rpm-55 rpm for 2 min-3 min. The adjuvant pretreated in step (1) was added, and the stirring speed was adjusted to 80 rpm-120 rpm for 6 min-10 min;

[0011] (5) Soybean lecithin was added, and the stirring speed was increased to 130 rpm-170 rpm for 2 min-4 min. The reaction vessel was cooled to 30 °C-50 °C, and the 1,8-cineole and capryl capryl capryl glycerol ester mixture prepared in step (3) was added at a rate of 0.5 mL / min-1.5 mL / min while stirring at 40 rpm-60 rpm. After the addition was completed, the stirring was continued at 60 rpm-100 rpm for 4 min-6 min;

[0012] (6) The mixture prepared in step (5) was naturally cooled to 20 °C-30 °C, and then pressed into a sugar blank by a tablet press. The sugar blank was cut into granules by a cutting machine.

[0013] The stirring was performed by a paddle stirrer with a paddle diameter of 7 cm.

[0014] The temperature of the high-pressure homogenizer in step (3) was 35 °C-45 °C.

[0015] The sugar blank in step (6) was 12 cm long, 6 cm wide, and 2 mm thick.

[0016] The granules in step (6) were 3 cm long, 1 cm wide, and 2 mm thick.

[0017] The training method for improving working memory using the chewing gum combined with computerized tasks, characterized in that the N-back task is used as the computerized training task, and the 1,8-eudesmol chewing gum is used in the training task, with a cycle of 3 consecutive days, and 1 hour of training arranged each day.

[0018] The 1 hour of training each day is as follows: the user enters a quiet, ventilated room with a temperature of 20-30℃, uses a computer installed with the N-back task to perform computerized task training, and simultaneously starts chewing the 1,8-eudesmol chewing gum. First, the spatial 3-back task is started, and training is performed for 3 minutes. After a 1-minute rest, the spatial 5-back task is started, and training is performed for 3 minutes. After a 1-minute rest, the adaptive N-back task is started, and training is performed for 3 minutes, with the adaptive N-back task repeated 4 times. The chewing gum is spit out, and a 10-minute rest is taken. The chewing gum is replaced, and the above training process is repeated once.

[0019] The adaptive N-back task is as follows: the load coefficient N of the current task is adjusted according to the performance of the previous module. If the response accuracy rate of the last block is higher than 85%, the load coefficient N of the current block will be increased by 1. Otherwise, the load coefficient N will be the same as that of the last block. In all subsequent training days, the starting load coefficient N is determined according to the N value at the end of the last training according to the above standard.

[0020] The use method of the 1,8-eudesmol chewing gum is as follows: when the training starts, the user synchronously chews the 1,8-eudesmol chewing gum at a frequency of 30-50 times / minute, and stops chewing at the end of each training task. Each piece of chewing gum is used to cover the entire training stage, and the chewing gum is replaced after the first stage is completed. The total daily amount is 2 pieces.

[0021] The present application is directed to the characteristics of low addition amount and poor water solubility of 1,8-eucalyptol. Traditional hydrophilic carriers represented by glycerol cannot achieve effective dissolution and stabilization. By screening, glyceryl caprylate and caprate are used as liposoluble carriers, which have excellent compatibility with terpenes and can form a stable system. Key process control points include: precise control of the temperature of each mixing stage to achieve the best emulsification effect; ensure uniform dispersion of each component by using a staged gradient stirring process; add active ingredients at room temperature. The last stage, the pretreated 1,8-eucalyptol-glyceryl caprylate and caprate mixture is added in the final mixing stage, which minimizes the impact of high temperature on active ingredients. This innovative process not only solves the stabilization problem of low content active ingredients, but also significantly improves the aroma retention rate of the product under storage conditions of 25℃, while achieving slow release and uniform distribution of the functional ingredient 1,8-eucalyptol monomer. The present application innovatively proposes a cognitive enhancement program combining 1,8-eucalyptol chewing gum with working memory training, breaking through the limitations of traditional non-invasive neural stimulation techniques such as transcranial electrical stimulation and transcranial magnetic stimulation. Compared with these technical solutions that require professional equipment, complex operation and high cost, the chewing gum intervention method of the present application has the advantages of safety, easy use, low cost and wide application scenarios. In terms of technical implementation, the present application develops a 1,8-eucalyptol monomer chewing gum, which successfully solves the technical problems of 1,8-eucalyptol monomer volatility and strong taste stimulation by optimizing the formula and preparation process. Using glyceryl caprylate and caprate as a fragrance locking carrier, through key technologies such as staged mixing and post-adding active ingredients, the active ingredients are maximized, the stability and slow release of the active ingredients are significantly improved, and the product has more lasting efficacy. The chewing gum is used during the execution of the training task, enhancing working memory capacity through compound stimulation. This program fully utilizes the functions of 1,8-eucalyptol, including anti-inflammatory and cognitive function enhancement. By combining compound stimulation with computerized task training, the limitations of traditional neural stimulation techniques requiring professional personnel and equipment are avoided, making working memory training not only safe and effective but also easy to operate. It is especially suitable for daily training of high brain load groups, memory decline groups and other groups that need cognitive enhancement. Compared with existing working memory training enhancement programs, the present application has the following advantages: high safety, good effect, short training period, wide use, and high compliance. It provides an innovative, practical and economical solution for cognitive function training and enhancement. DETAILED DESCRIPTION

[0022] In order to facilitate the understanding of the present application, a more comprehensive description of the present application will be provided below. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive.

[0023] The various raw materials used in the following examples, unless otherwise specified, are commercially available products known in the art. Among them, the gum base is purchased from Wuxi Yueda Gum Base Co., Ltd. (item number: 7081), D-mannitol (item number W00236, GB 1886.177-2016), erythritol (item number 002, GB 26404-2011), soy lecithin (item number 4742748493029, GB 1886.238-2016), gum arabic (item number 4488632225734, GB 29949-2013) are purchased from Hangzhou Tairen Biotechnology Co., Ltd., Brazil palm wax (CAS number: 14.008, GB 1886.84-2015), caprylic capric glyceride (CNS number: 10.018, GB 28302-20) are purchased from Shanghai Weiqing Import and Export Co., Ltd., the above raw materials all meet the corresponding national standards, and the addition amount complies with the food additive standard GB 2760-2024. 1,8-cineole (CAS: 470-82-6, GB 1886.119-2015) is purchased from Jiangxi Zhongxiang Biotechnology Co., Ltd.

[0024] Example 1

[0025] A chewing gum based on composite stimulation, comprising the following raw material components in parts by weight: 1,8-cineole 0.1 parts, gum base 42 parts, D-mannitol 33.5 parts, erythritol 10.6 parts, purified water 15 parts, caprylic capric glyceride 2 parts, soy lecithin 0.5 parts, gum arabic 0.28 parts, Brazil palm wax 0.06 parts.

[0026] The preparation method of the chewing gum based on composite stimulation is carried out according to the following steps:

[0027] (1) Chewing gum auxiliary preparation: D-mannitol, erythritol and purified water are added to a reaction container, and stirred at a speed of 300 rpm under the condition of 53°C oil bath heating for 10 min, then gum arabic and Brazil palm wax are added in turn, and stirring is continued for 15 min to form a homogeneous emulsion system; the stirring uses a paddle stirrer with a paddle diameter of 7 cm;

[0028] (2) Gum base pretreatment: the gum base is placed in a 53°C oil bath pot and softened for 2h, and stirred every 30 min during the period; the softened gum base is transferred to a 50°C constant temperature box;

[0029] (3) Active ingredient pretreatment: 1,8-cineole and caprylic capric glyceride are mixed at room temperature, and a high-pressure homogenizer is used to cycle process 3 times at a pressure of 60 MPa to form a stable microemulsion system; the temperature of the high-pressure homogenizer treatment is 40°C;

[0030] (4) Add the auxiliary materials prepared in step (1) to the gum base prepared in step (2) under the condition of an oil bath at 50°C, stir at 50 rpm for 3 min, and then stir at 100 rpm for 8 min;

[0031] (5) Add soybean lecithin, increase the stirring speed to 150 rpm, and stir for 3 min. Cool the reaction container to 40°C, and then add the 1,8-eucalyptol and glyceryl caprylate / caprate mixture prepared in step (3) at a speed of 1 mL / min at room temperature while stirring at 50 rpm. After the addition is completed, continue stirring at 80 rpm for 5 min;

[0032] (6) After the mixture prepared in step (5) is naturally cooled to 25°C, it is pressed into a sugar blank (12 cm long, 6 cm wide, and 2 mm thick) by a tablet press. The sugar blank is cut into granules (3 cm long, 1 cm wide, and 2 mm thick) by a cutting machine. The granules are packaged with an aluminum-coated composite film on an automatic packaging machine and subjected to sterilization treatment to obtain a 1,8-eucalyptol chewing gum.

[0033] Example 2

[0034] A chewing gum based on composite stimulation comprises the following raw material components in parts by weight: 1,8-eucalyptol 0.105 parts, gum base 43 parts, D-mannitol 28.9 parts, erythritol 10.6 parts, purified water 15 parts, glyceryl caprylate / caprate 1.5 parts, soybean lecithin 0.4 parts, gum arabic 0.3 parts, and carnauba wax 0.08 parts.

[0035] The preparation method of the chewing gum based on composite stimulation is carried out according to the following steps:

[0036] (1) Preparation of chewing gum auxiliary materials: Add D-mannitol, erythritol, and purified water into a reaction container, stir at a speed of 400 rpm for 8 min under the condition of an oil bath at 50°C, and then sequentially add gum arabic and carnauba wax and continuously stir for 10 min to form a homogeneous emulsion system. The stirring is carried out using a paddle stirrer with a paddle diameter of 7 cm;

[0037] (2) Gum base pretreatment: Soften the gum base in an oil bath at 50°C for 1 h, and stir every 20 min during the process. After softening, transfer the gum base to a thermostat at 48°C;

[0038] (3) Active ingredient pretreatment: Mix 1,8-eucalyptol and glyceryl caprylate / caprate at room temperature, and then treat the mixture using a high-pressure homogenizer at a pressure of 45 MPa for 4 cycles to form a stable microemulsion system. The temperature of the high-pressure homogenizer is 35°C;

[0039] (4) Place the glue base pretreated in step (2) in an oil bath at 45°C and stir at 45 rpm for 2 min. Add the excipients pretreated in step (1) and adjust the stirring speed to 80 rpm and stir for 10 min.

[0040] (5) Add soybean lecithin, increase the speed to 130 rpm and stir for 4 min. Cool the reaction vessel to 30°C. Add the mixture of 1,8-cineole and caprylic / decanoic acid glycerides prepared in step (3) at a rate of 0.5 mL / min at room temperature. Add and stir at 40 rpm. After the addition is complete, continue stirring at 60 rpm for 6 min.

[0041] (6) After the mixture prepared in step (5) is naturally cooled to 22°C, it is pressed into shape by a tablet press to make a sugar blank (12cm long, 6cm wide, and 2mm thick). The sugar blank is cut into granules (3cm long, 1cm wide, and 2mm thick) by a cutting machine. The granules are packaged on an automatic packaging machine with an aluminum-coated composite film and sterilized to obtain 1,8-cineole chewing gum.

[0042] Example 3

[0043] A chewing gum based on compound stimulation comprises the following raw material components in parts by weight: 0.095 parts of 1,8-cineole, 40 parts of gum base, 28.2 parts of D-mannitol, 12 parts of erythritol, 17 parts of purified water, 1.2 parts of caprylic / capric triglyceride, 0.8 parts of soybean lecithin, 0.4 parts of gum arabic, and 0.1 parts of carnauba wax.

[0044] The preparation method of the chewing gum based on compound stimulation is carried out according to the following steps:

[0045] (1) Preparation of chewing gum excipients: D-mannitol, erythritol and purified water were added to the reaction vessel and stirred at 400 rpm for 8 min under the oil bath heating condition of 55℃. Then, gum arabic and carnauba wax were added in sequence and stirred for 20 min to form a homogeneous emulsion system. The stirring was carried out by a paddle stirrer with a blade diameter of 7 cm.

[0046] (2) Pretreatment of the adhesive base: The adhesive base is placed in a 55℃ oil bath for 6 hours to soften, and is stirred every 40 minutes during the period. The softened adhesive base is then transferred to a 50℃ constant temperature box.

[0047] (3) Pretreatment of active ingredients: 1,8-cineole and caprylic / capric triglycerides were mixed at room temperature and circulated twice using a high-pressure homogenizer at 80 MPa to form a stable microemulsion system; the high-pressure homogenizer was used at a temperature of 45°C.

[0048] (4) The pre-processed gum base of step (2) is stirred at 55 rpm for 2 min in an oil bath at 55°C, and the pre-processed auxiliary material of step (1) is added, and the stirring speed is adjusted to 120 rpm for stirring for 6 min;

[0049] (5) Soybean lecithin is added, and the stirring speed is increased to 170 rpm for stirring for 2 min, and the reaction container is cooled to 50°C, and the mixture of 1,8-eucalyptol and caprylic capric glyceride prepared in step (3) is added at a speed of 1.5 mL / min at room temperature, and the stirring is performed at 60 rpm during the addition, and after the addition is completed, the stirring is continued at 60 rpm for 6 min;

[0050] (6) After the mixture prepared in step (5) is naturally cooled to 30°C, it is pressed and formed into a sugar blank (12 cm long, 6 cm wide, and 2 mm thick) by a tablet press, and the sugar blank is cut into particles (3 cm long, 1 cm wide, and 2 mm thick) by a cutting machine; and the particles are packaged with an aluminized composite film on an automatic packaging machine, and subjected to sterilization treatment, thereby obtaining 1,8-eucalyptol chewing gum.

[0051] Example 4: Sensory index evaluation

[0052] The 1,8-eucalyptol chewing gum products prepared in Examples 1 to 3 are subjected to comprehensive evaluation by 20 users in terms of color, fragrance retention, taste, texture, and chewing time, and the results are shown in Table 1 below.

[0053] Table 1: Quality evaluation table

[0054]

[0055] As can be seen from the above results, the 1,8-eucalyptol chewing gum of Example 2 has a clean and smooth surface, moderate luster and aroma, good elasticity and hardness, and good chewability without sticking to the teeth. Through comparison, the final formula is determined as the formula in Example 2.

[0056] Example 5: Process optimization-locking agent screening and optimization

[0057] In order to compare the locking effect of glycerol and caprylic capric glyceride on 1,8-eucalyptol monomers, a method combining sensory evaluation is used; five concentration gradients (0.5%, 1%, 1.5%, 2%, and 2.5%) of glycerol and caprylic capric glyceride parallel experimental groups are set; under the conditions of temperature 25±2°C and humidity 60±5%, the aroma component retention rate is detected daily for 14 days. The experimental data shows that on the 14th day: the aroma retention rate of 1,8-eucalyptol is significantly better than that of the glycerol system (Table 2).

[0058] Table 2

[0059]

[0060] Safety evaluation of 1,8-cineole in Example 6

[0061] The 1,8-cineole used in the chewing gum in this application meets the relevant provisions in GB 1886.119-2015. The amount of 1,8-cineole added is used in an appropriate amount according to the GB 2760-2024 standard as needed for production; the daily intake required in the World Health Organization Toxicology Monograph, Food Additives Series No. 52, is not more than 2.115 mg / day.

[0062] The mass of each piece of the chewing gum is 1.00 g, and no more than 2 pieces are consumed per day in this training program, and the amount of 1,8-cineole added is not more than 1.05 mg per piece, which meets the safe daily dosage for consumption.

[0063] Example 7 Training program effect test of 1,8-cineole chewing gum combined with computerized tasks to improve working memory

[0064] The experimental procedure is as follows: 50 subjects, 23 females and 27 males, aged 18-35 years, are enrolled. The entire experiment lasts for 5 days, with baseline testing and post-training testing on the 1st day and the 5th day, and a training period of 3 consecutive days, with 1 hour of training arranged each day, divided into two sessions. The experimental group chews 1,8-cineole chewing gum while training for 3 days, with 1 piece replaced every 30 minutes, for a total of 2 pieces. The control group performs the same tasks without chewing. The specific arrangements are as follows:

[0065] Day 1: The subjects enter a quiet, normally ventilated room with a temperature of 25℃±5℃, use a computer installed with the N-back task to perform a brief practice to ensure their familiarity with the spatial and numerical N-back tasks, and wear fNIRS. Baseline testing: First, perform the spatial N-back test, start the spatial 3-back task, test for 2.5 minutes; rest for 1 minute, then start the spatial 5-back task, test for 2.5 minutes; rest for 1 minute, then start the spatial 3-back task, test for 2.5 minutes; rest for 1 minute, then start the spatial 5-back task, test for 2.5 minutes. Each task is performed 50 times, 2.5 minutes (150s = 50 trials x 3s / trial), for a total of 4 tasks, 13 minutes.

[0066] Day 2-4 (training phase): 1 hour training per day is as follows: N-back task is used as a computerized task, and 1,8-cineole chewing gum is used in the training task, the specific method is as follows: the subject enters a quiet room, uses a computer installed with N-back task to perform computerized task training, starts chewing 1,8-cineole chewing gum, at the same time, starts spatial 3-back task, trains for 3 minutes; after 1 minute of rest, start spatial 5-back task, train for 3 minutes; after 1 minute of rest, start adaptive N-back task, train for 3 minutes (the adaptive N-back task is repeated 4 times); spit out the chewing gum, rest for 10 minutes, replace the chewing gum and repeat the above training process once.

[0067] Training method of 1,8-cineole chewing gum during training: when the training starts, the user synchronously chews 1,8-cineole chewing gum at a frequency of 30-50 times / minute, and stops chewing at the end of each training task. Each piece of chewing gum is used to cover the entire training phase, and the chewing gum is replaced after the first phase is completed, and the total daily amount is 2 pieces.

[0068] Adaptive mode: the load adaptive n-back task in this study means that the load factor n of the current module is adjusted according to the performance of the last module. In order to increase the difficulty of the training task, if the response accuracy rate of the last block is better than 85%, the load factor n of the current block will increase by 1. Otherwise, the load factor n will be the same as the last block. In all subsequent training days, the starting load factor n is determined by the performance of each person at the end of the last training. The load factor n has no specified upper limit, and the maximum value they can reach in training depends on the training effect.

[0069] Day 5: the subject enters a quiet room and wears fNIRS. Post-training test: first, spatial N-back test is performed, spatial 3-back task is started, and test is performed for 2.5 minutes; after 1 minute of rest, spatial 5-back task is started, and test is performed for 2.5 minutes; after 1 minute of rest, spatial 3-back task is started, and test is performed for 2.5 minutes; after 1 minute of rest, spatial 5-back task is started, and test is performed for 2.5 minutes. Each task is performed for 50 trials, 2.5 minutes (150s=50 trials x 3s / trial), a total of 4 tasks, for a total of 13 minutes.

[0070] Table 3 is the result of clinical trials of 1,8-cineole chewing gum on normal young people according to the present application, a total of 50 experimental cases, 23 females and 27 males, aged 18-35. There are 25 cases in the experimental group and 25 cases in the control group.

[0071] Table 3 average improvement rate

[0072]

[0073] The typical cases are as follows:

[0074] Cao, male, 32 years old, the correct rate of initial memory task test is 67%, after using the 1,8-eucalyptol chewing gum of the application in 3-day memory training task, the attention is enhanced, the working memory ability is improved, the correct rate of memory task test reaches 97%, and it is stated that the memory efficiency is increased in the task process.

[0075] Huang, female, 28 years old, the correct rate of initial memory task test is 65%, after eating the 1,8-eucalyptol chewing gum of the application in 3-day memory training task, the attention is enhanced, the working memory ability is improved, the correct rate of memory task test reaches 99%, and the working memory ability is improved.

[0076] The above-mentioned embodiments only express several embodiments of the present application, and the description is more specific and detailed, but it cannot be understood as the limitation of the scope of the patent. It should be pointed out that for ordinary skilled in the art, without departing from the concept of the present application, a number of modifications and improvements can be made, which belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.

Claims

1. A chewing gum based on compound stimulation, characterized in that, The raw material components include the following parts by weight: 0.09-0.105 parts of 1,8-cineole, 40-45 parts of gum base, 25-35 parts of D-mannitol, 8-15 parts of erythritol, 12-18 parts of purified water, 1-2 parts of caprylic / capric triglycerides, 0.3-0.8 parts of soybean lecithin, 0.2-0.4 parts of gum arabic, and 0.05-0.1 parts of carnauba wax.

2. The method for preparing the chewing gum based on compound stimulation as described in claim 1, characterized in that, Follow these steps: (1) Preparation of chewing gum excipients: D-mannitol, erythritol and purified water are added to the reaction vessel and stirred at 200rpm-400rpm for 8min-12min under oil bath heating at 50℃-55℃. Then gum arabic and carnauba wax are added in sequence and stirred for 10min-20min to form a homogeneous emulsion system. (2) Pretreatment of the adhesive base: Place the adhesive base in an oil bath at 50℃-55℃ for 1h-25h, and stir it every 20min-40min during the period. After softening, transfer the adhesive base to a constant temperature box at 48℃-50℃. (3) Pretreatment of active ingredients: 1,8-cineole and caprylic / capric triglyceride were mixed at room temperature and circulated 2-4 times using a high-pressure homogenizer at 40MPa-80MPa pressure to form a stable microemulsion system. (4) Place the glue base pretreated in step (2) in an oil bath at 45℃-55℃ and stir at 45rpm-55rpm for 2min-3min. Add the auxiliary materials pretreated in step (1) and adjust the stirring speed to 80rpm-120rpm and stir for 6min-10min. (5) Add soybean lecithin, increase the speed to 130rpm-170rpm and stir for 2-4min. Cool the reaction vessel to 30℃-50℃. Add the mixture of 1,8-cineole and caprylic / decanoic acid glycerides prepared in step (3) at a rate of 0.5mL / min-1.5mL / min at room temperature, while stirring at 40rpm-60rpm. After the addition is complete, continue stirring at 60rpm-100rpm for 4min-6min. (6) After the mixture prepared in step (5) is naturally cooled to 20℃-30℃, it is pressed into shape by a tablet press to make sugar blanks, and the sugar blanks are cut into granules by a cutting machine.

3. The method for preparing chewing gum based on compound stimulation according to claim 2, characterized in that, The mixing is carried out using a paddle mixer with a blade diameter of 7cm.

4. The method for preparing chewing gum based on compound stimulation according to claim 2, characterized in that, The high-pressure homogenizer in step (3) processes the material at a temperature of 35℃-45℃.

5. The method for preparing chewing gum based on composite stimulation according to claim 2, characterized in that, The sugar blank in step (6) is 12cm long, 6cm wide, and 2mm thick.

6. The method for preparing chewing gum based on compound stimulation according to claim 2, characterized in that, The particles described in step (6) are 3cm long, 1cm wide, and 2mm thick.

7. A training method for improving working memory using chewing gum combined with computerized tasks as described in claim 1 or 2, characterized in that, The N-back task was used as the computerized training task. 1,8-cineole chewing gum was used in the training task, and the cycle was 3 consecutive days, with 1 hour of training arranged each day.

8. The training method for improving working memory by combining chewing gum with computerized tasks according to claim 7, characterized in that, The daily 1-hour training session is as follows: The user enters a quiet, well-ventilated room with a temperature between 20°C and 30°C, uses a computer equipped with an N-back task for computerized task training, and simultaneously begins chewing 1,8-cineole chewing gum. First, the user begins the spatial 3-back task for 3 minutes; after a 1-minute rest, the user begins the spatial 5-back task for 3 minutes; after a 1-minute rest, the user begins the adaptive N-back task for 3 minutes, and the adaptive N-back task is repeated 4 times; the user spits out the chewing gum and rests for 10 minutes; the user then replaces the chewing gum and repeats the above training process once.

9. The training method for improving working memory by combining chewing gum with computerized tasks according to claim 7, characterized in that, The adaptive N-back task is as follows: the load factor N of the current task is adjusted according to the performance of the previous module; if the response accuracy of the last block is higher than 85%, the load factor N of the current block will be increased by 1. Otherwise, the load factor N will be the same as the last block; in all subsequent training days, the initial load factor N will be determined by the N value at the end of the previous training session according to the above criteria.

10. The training method for improving working memory by combining chewing gum with computerized tasks according to claim 7, characterized in that, Instructions for use of the 1,8-cineole chewing gum: When training begins, the user chews the 1,8-cineole chewing gum synchronously at a frequency of 30-50 times / minute. Chewing is stopped during rest periods after each training task. Each chewing gum is used to cover the entire training phase. Replace the chewing gum after the first phase is completed. The total daily dosage is 2 gums.

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