Traditional Chinese medicine preparation formula for treating sexual infectious diseases and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine preparation formula for treating sexual infectious diseases. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-15 parts of coptis chinensis, 5-15 parts of scutellaria baicalensis, 5-15 parts of golden cypress, 5-15 parts of cape jasmine, 10-20 parts of honeysuckle, 10-20 parts of dandelion, 5-15 parts of chrysanthemum, 5-15 parts of philippine violet herb, 5-15 parts of gynura bicolor, 10-20 parts of houttuynia cordata, 5-15 parts of hairyvein agrimony, 5-15 parts of patrinia, 5-15 parts of fructus forsythiae, 10-30 parts of astragalus, 5-10 parts of divaricate saposhnikovia root, 5-15 parts of reed rhizome, 5-15 parts of salvia miltiorrhiza, 5-15 parts of poria cocos and 5-10 parts of curcuma zedoary. 5-15 parts of lucid ganoderma, 5-15 parts of bighead atractylodes rhizome and 5-10 parts of tendril-leaved fritillary bulb; according to the traditional Chinese medicine composition, large-dose heat-clearing and detoxifying medicines such as coptis chinensis, scutellaria baicalensis, golden cypress, honeysuckle and dandelion are used as monarch medicines, fructus forsythiae, houttuynia cordata and patrinia herb are used as auxiliary medicines, and the traditional Chinese medicine composition has broad-spectrum inhibition and killing effects on pathogens of various sexually transmitted diseases such as gonococcus, treponema pallidum, HSV, HPV, HIV and parasites, and can effectively control infection symptoms.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation formula for treating sexually transmitted diseases and a preparation method thereof. BACKGROUND

[0002] Sexually transmitted diseases are a class of diseases that are transmitted through sexual behavior (including vaginal sex, anal sex and oral sex, etc.), and have become a global public health problem. There are more than 30 known pathogens, including bacteria (such as Neisseria gonorrhoeae, Treponema pallidum), viruses (such as herpes simplex virus HSV-1 / 2, human immunodeficiency virus HIV, human papillomavirus HPV) and parasites (such as Trichomonas vaginalis) and the like.

[0003] At present, the treatment of sexually transmitted diseases in Western medicine mainly relies on chemical synthetic drugs such as antibiotics and antiviral drugs. However, these therapies have many limitations:

[0004] Drug resistance problem is increasingly serious: such as Neisseria gonorrhoeae has developed resistance to fluoroquinolones, azithromycin and other conventional antibiotics, leading to treatment failure.

[0005] Cannot be cured, easy to relapse: for herpes simplex virus (HSV), human papillomavirus (HPV) and other viral infections, there is no specific drug to completely eliminate latent viruses at present, and the disease shows a chronic recurrent process.

[0006] Side effects: such as the "cocktail therapy" for AIDS can inhibit viruses, but it needs to be taken for life, and may produce strong side effects, and viruses are prone to drug resistance.

[0007] Incomplete treatment: such as incomplete treatment of syphilis, which is prone to recurrence due to factors such as decreased immunity.

[0008] Traditional Chinese medicine theory believes that sexually transmitted diseases are mostly caused by "unclean sex, infection of damp-heat evil toxin, and accumulation in lower jiao". However, modern people have complex conditions such as "cold-heat mixture", "upper heat and lower cold", and "deficiency of the healthy and excess of the evil" due to factors such as improper diet, irregular life, and mixed use of Chinese and Western medicine. Single heat-clearing and detoxification or single tonifying prescription is difficult to work, therefore, a traditional Chinese medicine preparation formula for treating sexually transmitted diseases and a preparation method thereof are proposed. SUMMARY

[0009] Therefore, the embodiments of the present application provide a traditional Chinese medicine preparation formula for treating sexually transmitted diseases and a preparation method thereof, so as to solve or alleviate the technical problems in the prior art, and at least provide a beneficial choice.

[0010] The technical scheme of the embodiments of the present application is as follows: a traditional Chinese medicine preparation formula for treating sexually transmitted diseases is prepared from the following raw medicinal materials by weight: Huanglian 10 parts, Huangqin 10 parts, Huangbo 10 parts, Zhizi 10 parts, Jin yinhua 15 parts, Pugongying 15 parts, Juhua 10 parts, Zihua dinding 10 parts, Zibei tiankuizi 10 parts, Yuxingcao 15 parts, Xianhecao 10 parts, Baijiangcao 10 parts, Lianqiao 10 parts, Huangqi 20 parts, Fangfeng 8 parts, Lugen 10 parts, Danshen 10 parts, Fuling 10 parts, E zhu 8 parts, Lingzhi 10 parts, Baizhu 10 parts and Chuanbei 8 parts.

[0011] In some embodiments, the weight parts of each raw drug are: Huanglian 10 parts, Huangqin 10 parts, Huangbo 10 parts, Zhizi 10 parts, Jin yinhua 15 parts, Pugongying 15 parts, Juhua 10 parts, Zihua dinding 10 parts, Zibei tiankuizi 10 parts, Yuxingcao 15 parts, Xianhecao 10 parts, Baijiangcao 10 parts, Lianqiao 10 parts, Huangqi 20 parts, Fangfeng 8 parts, Lugen 10 parts, Danshen 10 parts, Fuling 10 parts, E zhu 8 parts, Lingzhi 10 parts, Baizhu 10 parts and Chuanbei 8 parts.

[0012] A preparation method of a traditional Chinese medicine preparation for treating infectious diseases, comprising the following steps: S1, pretreatment and drying: mixing raw drugs according to the ratio, and drying according to the category; S2, crushing and screening: preliminarily crushing the large pieces of raw materials after drying, and then screening through different mesh screening machines to remove particles and foreign matters that do not meet the standards; S3, low-temperature grinding: placing the screened raw drugs in a frozen grinding machine, cooling to-196℃ using liquid nitrogen, and mechanically grinding until ultra-fine powders with a center particle size of 5-10μm or less are obtained, so as to realize cell wall breaking; S4, composite extraction: adding the ultra-fine powders into an extraction tank, adding 5-10 times of purified water or 50-75% of ethanol, and performing reflux extraction at 25-40℃ for 2-3 times, each time for 1-2 hours, combining the extraction liquids, filtering to obtain a filtrate; S5, biological fermentation: inoculating the extraction liquid with probiotics or yeast under the conditions of pH value of 5.5-6.5 and temperature of 38-45℃ for 4-72 hours, so as to enhance active ingredients and improve bioavailability; S6, instant sterilization: rapidly increasing the temperature of the fermented extraction liquid to 121℃, maintaining for 15 seconds, and then rapidly cooling to 50℃, which can kill 98% of bacteria or microorganisms while retaining the activity of medicinal materials to the greatest extent; S7, low-temperature concentration: concentrating the sterilized extraction liquid in a low-temperature environment of 50℃ until a preparation finished product is obtained.

[0013] In some embodiments, in S1, drying by category includes drying flowers, leaves, and whole grasses at 20-30°C; drying rhizomes at 30-65°C; drying fruits at 70-90°C; drying volatile oil-containing plants at 25-30°C; and drying glycoside- and alkaloid-containing plants at 50-60°C.

[0014] In some embodiments, in S3, the low-temperature grinding makes the plant cell walls and contents brittle and lose toughness using liquid nitrogen, so that the cell walls are broken under mechanical external force, while the low-temperature environment inhibits the activity of enzymes and chemical reactions, and protects heat-sensitive and easily-oxidized components.

[0015] In some embodiments, in S5, the biological fermentation is a biological transformation process that uses microorganisms or enzymes to decompose plant raw materials under specific conditions to change or enhance active ingredients, produce new substances, or improve properties.

[0016] The embodiments of the present application have the following advantages due to the use of the above technical solutions: First, the present application uses large doses of heat-clearing and detoxifying drugs such as Huanglian, Huangqi, Huangbai, Jinyinhua, and Pugongying as the monarch, supplemented by Lianqiao, Yuxingcao, and Baijiangcao, which has a broad spectrum of inhibition and killing effect on pathogens of various sexually transmitted diseases, such as gonococci, syphilis spirochetes, HSV, HPV, HIV, and parasites, and can effectively control the symptoms of infection.

[0017] Second, the present application adds right-supporting and body-strengthening drugs such as Huangqi, Lingzhi, and Baishu, which can both "expel evil" and "support the right", and can effectively reduce the recurrence rate by treating both the symptoms and the root cause, and targeting the modern human's "right deficiency and evil excess" and "cold and heat mixed" constitution.

[0018] Third, the present application can play a role in multiple links such as inhibiting pathogen replication, blocking infection pathways, regulating the body's immunity, and anti-inflammatory analgesia through the synergistic effect of multiple active ingredients in the present application. This multi-target mechanism is not prone to drug resistance, and is especially suitable for cases with drug resistance to Western medicine.

[0019] Fourth, the present application can improve local blood circulation, promote inflammation absorption and tissue repair, and has good therapeutic effect on genital ulcers and pelvic inflammation by adding blood-activating and stasis-removing drugs such as Danshen and Eshu.

[0020] The above summary is only for the purpose of the description and is not intended to limit in any way. DETAILED DESCRIPTION

[0021] In the following, only certain exemplary embodiments are simply described. As those skilled in the art can recognize, the described embodiments can be modified in various different ways without departing from the spirit or scope of the present application.

[0022] It should be noted that the terms "first", "second", "symmetrical", "array", "provided with", "provided in" and the like are only used for distinguishing description and position description purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined with "first", "symmetrical" and the like can explicitly or implicitly include one or more of the features; similarly, for some features that are not limited in number by the words "two", "three" and the like, it should be noted that the features also belong to explicitly or implicitly including one or more feature quantities.

[0023] In the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "fixing" and the like should be understood in a broad sense; for example, it can be fixed connection, or detachable connection, or one-piece molding; it can be mechanical connection, it can be direct connection, it can be welding, it can be indirect connection through an intermediate medium, or it can be the communication or interaction relationship between two elements.

[0024] The present application provides a traditional Chinese medicine preparation formula for treating infectious diseases, which is made of the following raw medicinal materials by weight: Huanglian 5-15 parts, Huangqin 5-15 parts, Huangbo 5-15 parts, Zhizi 5-15 parts, Jinyinhua 10-20 parts, Pugongying 10-20 parts, Juhua 5-15 parts, Zihua Diding 5-15 parts, Zibei Tiangukui 5-15 parts, Yuxingcao 10-20 parts, Xianhecao 5-15 parts, Baijiangcao 5-15 parts, Lianqiao 5-15 parts, Huangqi 10-30 parts, Fangfeng 5-10 parts, Lugen 5-15 parts, Danshen 5-15 parts, Fuling 5-15 parts, Eshu 5-10 parts, Lingzhi 5-15 parts, Baishu 5-15 parts and Chuanbei 5-10 parts.

[0025] In the present embodiment, the weight parts of each raw medicinal material are specifically: Huanglian 10 parts, Huangqin 10 parts, Huangbo 10 parts, Zhizi 10 parts, Jinyinhua 15 parts, Pugongying 15 parts, Juhua 10 parts, Zihua Diding 10 parts, Zibei Tiangukui 10 parts, Yuxingcao 15 parts, Xianhecao 10 parts, Baijiangcao 10 parts, Lianqiao 10 parts, Huangqi 20 parts, Fangfeng 8 parts, Lugen 10 parts, Danshen 10 parts, Fuling 10 parts, Eshu 8 parts, Lingzhi 10 parts, Baishu 10 parts and Chuanbei 8 parts.

[0026] A preparation method of a traditional Chinese medicine preparation for treating infectious diseases, comprising the following steps: S1, pretreatment and drying: mixing the raw medicinal materials according to the proportion, and drying according to the category, S2, crushing and screening: the large pieces of raw materials after drying are preliminarily crushed, and then screened through different mesh sieving machines to remove particles and foreign matters that do not meet the standard, S3, low-temperature grinding: the screened crude drug is placed in a cryogenic grinder, cooled to -196°C using liquid nitrogen, and mechanically ground until ultrafine powder with a center particle size of 5-10 μm or less is obtained, achieving cell wall breaking, S4, composite extraction: the ultrafine powder is added to an extraction tank, 5-10 times the amount of purified water or 50-75% ethanol is added, and reflux extraction is performed at 25-40°C for 2-3 times, each time for 1-2 hours, the extraction liquid is combined and filtered to obtain the filtrate, S5, biological fermentation: the extraction liquid is inoculated with probiotics or yeast and fermented at a pH of 5.5-6.5 and a temperature of 38-45°C for 4-72 hours to enhance active ingredients and improve bioavailability, S6, instantaneous sterilization: the extraction liquid after fermentation is rapidly raised to 121°C, maintained for 15 seconds, and then rapidly cooled to 50°C, which can kill 98% of bacteria or microorganisms while maximizing the activity of the medicinal material, S7, low-temperature concentration: the sterilized extraction liquid is concentrated at 50°C in a low-temperature environment until the preparation is finished.

[0027] In this embodiment, specifically, in S1, drying by category includes drying flowers, leaves, whole grasses at 20-30°C, rhizomes at 30-65°C, fruits at 70-90°C, volatile oil-containing at 25-30°C, and glycoside and alkaloid-containing at 50-60°C.

[0028] In this embodiment, specifically, in S3, low-temperature grinding uses liquid nitrogen to make plant cell walls and contents brittle and lose toughness, thereby achieving wall breaking under mechanical external force, while the low-temperature environment inhibits enzyme activity and chemical reactions, protecting heat-sensitive and easily oxidized components.

[0029] In this embodiment, specifically, in S5, biological fermentation is a biological transformation process that uses microorganisms or their enzymes to decompose plant raw materials under specific conditions to change or enhance their active ingredients, produce new substances, or improve their properties.

[0030] In this embodiment, specifically, flowers, leaves, and whole grasses include honeysuckle, chrysanthemum, dandelion, purple flower ground ivy, fishy grass, bugbane, reed canary grass, and purple back sunflower seeds.

[0031] In this embodiment, specifically, rhizomes include Coptis, Scutellaria, Phellodendron, Salvia miltiorrhiza, Poria cocos, Curcuma zedoaria, Ganoderma lucidum, Atractylodes, Sichuan bezoar, and reed.

[0032] In this embodiment, specifically, fruits include gardenia and forsythia.

[0033] In this embodiment, specifically, volatile oil-containing includes chrysanthemum, fishy grass, wind-preventing and curcuma zedoaria.

[0034] In this embodiment, specifically, the ginsenosides and alkaloids include Coptis, Scutellaria, Phellodendron, Gardenia, Honeysuckle, Forsythia, Sophora and Bovis.

[0035] In this embodiment, specifically, Coptis, bitter in nature, cold in nature, belongs to heart, liver, stomach and large intestine.

[0036] Effect: Clearing heat and drying dampness, purging fire and detoxifying.

[0037]

Modern pharmacological research

[0038] Coptis has a wide range of antibacterial, against dysentery bacillus, salmonella, pseudomonas aeruginosa, escherichia coli, diphtheria bacillus, pertussis bacillus, tuberculosis bacillus, staphylococcus, meningococcal, hemolytic streptococcus, pneumococcus, etc. have obvious inhibitory effect; against leptospira, amoeba, trichomonas, influenza virus and many pathogenic skin fungi, also have inhibitory effect. Among them, the inhibitory effect on dysentery bacillus is the strongest. And can enhance the phagocytic ability of white blood cells;

[0039] Also has the effect of lowering blood pressure, choleretic, antipyretic, sedative, analgesic, antidiuretic, local anesthesia, etc.

[0040] In addition, it has a relaxing effect on vascular smooth muscle, and a relaxing and excitatory effect on uterine, bladder and gastrointestinal smooth muscle; Berberine and some of its derivatives have anticancer effect.

[0041] Coptis has anti-pathogenic microorganism effect.

[0042] (1) Antibacterial: The main component of coptis is berberine, which has broad-spectrum antibacterial effect. In vitro bacteriostatic experiment shows that coptis has obvious inhibitory effect on many cocci and bacilli. Coptis can inhibit bacteria at low concentration and kill bacteria at high concentration. Test tube method shows that it also has inhibitory effect on skin fungi.

[0043] (2) Antiviral: Chicken embryo experiment shows that coptis or berberine has obvious inhibitory effect on influenza virus PR8 strain, 56-S8 strain, influenza virus FM1 strain, influenza virus Iec strain, influenza virus 1233 strain and new virus.

[0044] (3) Anti-pathogenic: In vitro experiment shows that coptis or berberine has inhibitory effect on amoeba, trypanosome and black fever pathogen. It also has killing effect on leptospira and can resist trichomonas.

[0045] Coptis has anti-inflammatory effect.

[0046] Coptis has antipyretic and analgesic effects.

[0047] Coptis has antiarrhythmic effects. Berberine can prevent and treat experimental arrhythmia induced by calcium chloride, aconitine, barium chloride, adrenaline, electrical stimulation and coronary artery ligation in animals, and has a significant dose-effect relationship. It also has a good antagonistic effect on atrial fibrillation induced by calcium chloride-acetylcholine. Clinical studies have shown that berberine is effective in treating ventricular and atrial arrhythmias caused by various factors, indicating its broad-spectrum antiarrhythmic effects. Berberine has positive inotropic effects, slows heart rate, prolongs diastolic period, dilates resistance and capacitance vessels, and reduces blood pressure, thereby reducing the preload and afterload of the heart. Berberine also has certain anti-heart failure effects.

[0048] Coptis has platelet aggregation inhibitory effects.

[0049] Coptis has hypotensive effects. Berberine can lower arterial blood pressure, especially diastolic pressure.

[0050] Coptis has hypoglycemic effects. Berberine and Coptis decoction can inhibit gluconeogenesis and promote glycolysis to lower blood sugar.

[0051] Coptis has effects on the central nervous system. Small doses of berberine can stimulate the cerebral cortex of animals, while large doses have inhibitory effects.

[0052] Coptis has effects on relaxing arterial smooth muscle.

[0053] Coptis has hypolipidemic effects.

[0054] Coptis can enhance non-specific immune function.

[0055] Coptis has antioxidant effects, which can prevent and treat atherosclerosis.

[0056] Coptis has choleretic and anti-ulcer effects.

[0057] Coptis has anti-tumor effects.

[0058] Coptis also has leukocyte-elevating, anti-emetic and anti-diarrhea effects.

[0059] In the examples, specifically, Scutellaria, nature and taste, bitter, cold. It belongs to the lung, stomach, gallbladder and large intestine meridians.

[0060] Functions: Clearing heat and drying dampness, purging fire and detoxifying, cooling blood and stopping bleeding, and removing heat and soothing the fetus.

[0061] This product is also divided into old roots, which are good at clearing lung fire; young roots are good at clearing large intestine fire and purging damp-heat from the lower jiao.

[0062]

Modern pharmacological research

[0063] Scutellaria decoction has a broad spectrum of antibacterial spectrum in vitro, and has inhibitory effect on Salmonella typhi, Shigella dysenteriae, Pseudomonas aeruginosa, Bordetella pertussis, Staphylococcus, Streptococcus, Streptococcus pneumoniae, Streptococcus meningitidis, etc.

[0064] It also has inhibitory effect on influenza virus, leptospira and various pathogenic fungi.

[0065] In addition, it also has the functions of antipyretic, antihypertensive, diuretic, sedative, cholagogue, liver protection, reduction of capillary permeability, inhibition of intestinal peristalsis, etc.

[0066] Scutellaria has the effect of resisting pathogenic microorganisms. Studies have shown that Scutellaria has broad-spectrum antibacterial effect and inhibits various Gram-positive and Gram-negative bacteria, among which Staphylococcus aureus and Pseudomonas aeruginosa have the strongest inhibitory effect. It also has certain inhibitory effect on epidermophyton and other pathogenic fungi. The effective antibacterial component is baicalin. Scutellaria decoction and water decoction have inhibitory effect on influenza virus PR6 strain in vitro and have therapeutic effect on mice infected with influenza virus in vitro. In vitro experiments have also shown that Scutellaria has the effect of inhibiting the growth of amoeba and killing leptospira.

[0067] Scutellaria has anti-inflammatory and anti-allergic effects. Baicalin and baicalein can inhibit passive cutaneous allergic reactions. These two components can also inhibit experimental asthma and have antihistamine, anticholinergic and opiate-like effects. Baicalin and baicalein, wogonin can inhibit the increase of mouse abdominal cavity exudation caused by acetic acid, inhibit rat toe swelling caused by 48 / 80 (a compound) and rat adjuvant arthritis.

[0068] Scutellaria has antioxidant effect. Its main components baicalin, baicalein, wogonin, and new baicalein II have significant inhibitory effect on the generation of peroxidized lipids in liver tissue induced by ferric chloride-vitamin C-ADP or NADPH (reduced form of coenzyme II dehydrogenase)-ADP.

[0069] Scutellaria has the effect of resisting thrombus formation. Its various components can inhibit platelet aggregation. For example, baicalein, wogonin, new baicalein, and chrysin can inhibit platelet aggregation induced by collagen at a concentration of 110 mol / L; chrysin and baicalein, wogonin can also inhibit platelet aggregation induced by ADP and arachidonic acid, respectively. Baicalin and baicalein can also inhibit the transformation of fibrinogen into fibrin induced by thrombin, and can prevent diffuse intravascular coagulation induced by endotoxin. Its inhibitory effect on platelet aggregation is stronger than that of aspirin.

[0070] Scutellaria has diuretic effect, with baicalin having the strongest effect.

[0071] Scutellaria baicalensis Georgi has anti-tumor effect.

[0072] Scutellaria baicalensis Georgi has anti-endothelial cell damage effect.

[0073] Scutellaria baicalensis Georgi has antagonistic effect on adrenocorticotropic hormone.

[0074] Scutellaria baicalensis Georgi has inhibitory effect on phosphodiesterase, thus increasing cyclic adenosine monophosphate.

[0075] Scutellaria baicalensis Georgi has hemostatic effect. S, B, G2 effective monomers extracted therefrom exhibit hemostatic effect in animal experiments. Scutellarein and wogonoside have preventive and therapeutic effects on experimental pulmonary hemorrhage in mice caused by low air pressure.

[0076] Scutellaria baicalensis Georgi also has anti-radiation damage effect.

[0077] In the examples, specifically, Phellodendri Chinensis Cortex, nature and taste, meridian, bitter, cold. It belongs to kidney, bladder, large intestine meridian.

[0078] Function: Clearing heat and drying dampness, purging fire and detoxifying, reducing fever and eliminating steam.

[0079] This product contains berberine, phellodendrine and other alkaloids, in addition, phellodendron ketone, phellodendron inner fat, etc. Phellodendri Chinensis Cortex has similar antibacterial spectrum and antibacterial efficacy to Coptis chinensis. It can inhibit many pathogenic bacteria such as dysentery bacillus, typhoid bacillus, tuberculosis bacillus, staphylococcus aureus, and hemolytic streptococcus. It also has inhibitory effect on some skin fungi, leptospira, and hepatitis B surface antigen. It has protective effect on platelets. It can promote the absorption of subcutaneous bleeding when used externally. In addition, it also has the effects of promoting bile secretion, diuresis, lowering blood pressure, and relieving fever, but its effect is not as good as Coptis chinensis. Phellodendri Chinensis Cortex also has the effects of lowering blood sugar and promoting antibody production in mice.

[0080]

Modern pharmacological research

[0081] Phellodendri Chinensis Cortex has anti-inflammatory effect.

[0082] Phellodendri Chinensis Cortex has the effect of lowering blood pressure. Intravenous or intraperitoneal injection of Phellodendri Chinensis Cortex in anesthetized animals can produce significant and lasting hypotensive effect.

[0083] Phellodendri Chinensis Cortex can affect the effect of acetylcholine. In animal hearts in vivo and in vitro, small doses of berberine can enhance the effect of acetylcholine. Large doses of berberine can antagonize the contraction of isolated frog abdominal straight muscles caused by acetylcholine, which can be inhibited by phellodendrin.

[0084] Phellodendri Chinensis Cortex has inhibitory effect on central nervous system.

[0085] Phellodendri Chinensis Cortex has hypoglycemic effect.

[0086] Phellodendri Chinensis Cortex has positive inotropic effect and antiarrhythmic effect on cardiovascular system, and can delay the occurrence of arrhythmia during myocardial ischemia and reperfusion, and reduce the incidence and mortality of arrhythmia in rats.

[0087] Phellodendri Chinensis Cortex has effect on smooth muscle, and phellodendron ketone contained in Phellodendri Chinensis Cortex can enhance the tension and contraction amplitude of animal intestine. Phellodendri Chinensis Cortex powder can enhance the amplitude of contraction of isolated intestine of rabbits, and phellodendron lactone can inhibit the intestine.

[0088] Phellodendri Chinensis Cortex also has anti-ulcer, cell immunity inhibition and other effects.

[0089] In the examples, specifically, Gardenia, nature and taste, bitter, cold. Heart, liver, lung, stomach, Sanjiao.

[0090] Effect: purging fire and relieving restlessness, clearing heat and dampness, cooling blood and detoxifying, reducing swelling and relieving pain.

[0091] This product contains gardenia, gardenia, and safflower, safflower acid, etc. The fruit skin contains ursolic acid.

[0092] Gardenia decoction and alcohol extract have choleretic effect, can promote bile secretion, and can reduce blood bilirubin, can promote the rapid excretion of bilirubin in blood. It has inhibitory effect on hemolytic streptococcus and skin fungus. It has antipyretic, analgesic, sedative, antihypertensive and hemostatic effects.

[0093]

Modern pharmacological research

[0094] (1) Hepatoprotective effect: Gardenia can reduce the content of serum bilirubin, glutathione transaminase and alkaline phosphatase in rats caused by α-naphthyl isothiocyanate poisoning, Gardenia can reduce liver damage caused by CCl4, reduce degeneration and necrosis of liver cells, and restore the content of glycogen and ribonucleic acid stored in liver cells. Gardenia can reduce the activity of glutathione transaminase and bilirubin diphosphate uridine glycoside in animals with ligated common bile duct, or restore it to normal, and increase the activity of liver diphosphate uridine glycoside-dehydrogenase.

[0095] (2) Choleretic effect: alcohol extract, safflower, safflower acid and gennipin can increase bile secretion. Human consumption of gardenia decoction can significantly contract the gallbladder and promote bile excretion. Gardenia water and alcohol extract can reduce the content of bilirubin in the blood of rabbits with ligated common bile duct, and promote bilirubin metabolism.

[0096] (3) Influence on gastric juice secretion and gastrointestinal peristalsis: duodenal administration of geniposide can reduce gastric juice secretion in pylorus-ligated rats, and intravenous injection of dehydrogenated gardenia blue or geniposide can inhibit spontaneous gastric peristalsis and pilocarpine-induced gastric contraction in rats. Gardenia alcohol extract can stimulate small intestinal movement in rats and rabbits.

[0097] Gardenia has inhibitory effect on central nervous system.

[0098] Gardenia has effect on cardiovascular system: gardenia decoction and alcohol extract can reduce blood pressure in anesthetized or non-anesthetized cats, rabbits, and rats, regardless of oral or intravenous administration. Gardenia extract can reduce myocardial contractility, and gardenia decoction can slow heart rate and dilate blood vessels.

[0099] Gardenia has anti-inflammatory effect and certain therapeutic effect on soft tissue injury.

[0100] Gardenia has anti-pathogenic microorganism effect: gardenia decoction has inhibitory effect on diphtheria bacillus, staphylococcus aureus, and salmonella typhi, and water extract has inhibitory effect on various skin fungi.

[0101] Gardenia has coagulation effect, and its fried and roasted products can significantly shorten the clotting time of mice.

[0102] Gardenia has a laxative effect.

[0103] Extraction technology: By taking advantage of the difference in solubility of substances in different solvents, a specific component in a mixture can be transferred to another solvent, achieving separation. The most commonly used operation method is liquid-liquid extraction using a separatory funnel. Liquid-liquid extraction is a method of adding a solvent or liquid reagent that is not miscible or only slightly miscible with the sample solution to a separatory funnel, mixing thoroughly, and using the difference in solubility of the specific component in the two solvents to extract the component into the solvent with higher solubility, and separate it from the mixture.

[0104] In the examples, specifically, Honeysuckle, nature and taste meridian Gan, cold. Lung, heart, stomach meridian.

[0105] Effect: clearing heat and resolving toxins, dispersing wind-heat.

[0106] This product contains cyclohexane alcohol, flavonoids, inositol, saponins, tannins, etc. The leaves contain flavonoids and tannins. The stems contain saponins, etc.

[0107] This product has broad-spectrum antibacterial effect, and has strong inhibitory effect on pathogenic bacteria such as Staphylococcus aureus and Shigella dysenteriae, and also has inhibitory effect on various pathogenic microorganisms such as leptospira, influenza virus, and pathogenic fungi; It has obvious anti-inflammatory and antipyretic effects; The water and alcohol extract of honeysuckle has obvious cytotoxic effect on sarcoma 180 and ascites tumor of Ehrlich.

[0108] It has certain effect of reducing cholesterol.

[0109]

Modern pharmacological research

[0110] Flowers have anti-inflammatory, antipyretic, and anti-allergic effects, and extracts can inhibit rat toe swelling caused by chondrus and egg white.

[0111] Silver flower has an excitatory effect on the central nervous system.

[0112] Honeysuckle has anti-endotoxin effect.

[0113] Honeysuckle has a blood lipid-lowering effect.

[0114] Honeysuckle can improve immune function, and honeysuckle decoction can promote the phagocytic function of albumin, and intraperitoneal injection of honeysuckle injection in mice can also significantly promote the phagocytic function of inflammatory cells.

[0115] Honeysuckle has a liver-protecting and cholagogic effect.

[0116] Honeysuckle has an anti-fertility effect.

[0117] Honeysuckle has cytotoxic effect, and its extract can also stimulate gastrointestinal peristalsis, increase gastric juice and bile secretion. In addition, chlorogenic acid can also slightly enhance the pressor effect of adrenaline and norepinephrine on cats and rats.

[0118] In the examples, specifically, Dandelion, nature and flavor, bitter, sweet, cold. Liver, stomach.

[0119] Effect: Clearing heat and resolving toxin, resolving abscess and removing mass, removing dampness and relieving stranguria.

[0120] This product contains dandelion sterol, dandelion, dandelion bitter, etc.

[0121] Dandelion has strong inhibitory effect on staphylococcus aureus and hemolytic streptococcus; it has certain inhibitory effect on pneumococcus, meningococcus, diphtheria bacillus, pseudomonas aeruginosa, proteus, shigella, salmonella and catarrhal coccus.

[0122] In addition, it also has the effects of cholagogue, liver protection, diuresis, stomachic and laxative.

[0123] The decoction also has the effect of stimulating the body's immune function.

[0124] [Modern Pharmacological Research] Dandelion has antimicrobial activity: it has a strong killing effect on drug-resistant Staphylococcus aureus and hemolytic streptococci; its alcohol extract can inhibit Mycobacterium tuberculosis and also kill Leptospira, Helicobacter pylori, and certain fungi. Dandelion has an inhibitory effect on herpes simplex virus (1:400), and at a concentration of 1:80, it can delay the cytopathic effect of ECHO11 virus (orphan virus).

[0125] Dandelion has liver-protecting and choleretic effects.

[0126] Dandelion has anti-endotoxin properties.

[0127] Dandelion has anti-tumor effects.

[0128] Dandelion has an excitatory effect on isolated frog hearts in small doses, but an inhibitory effect in large doses.

[0129] Dandelion has the effect of inhibiting gastric acid secretion and resisting gastric ulcers.

[0130] Dandelion has the effect of influencing immune function: In vitro experiments have found that dandelion decoction can significantly increase the transformation rate of peripheral blood lymphocytes, suggesting that this product has the effect of stimulating the body's immune function.

[0131] Dandelion has a diuretic effect.

[0132] The roots and whole plant of dandelion can be used as a bitter stomachic or a mild laxative. The infusion can treat snake bites and also promote lactation.

[0133] Extraction technology: Liquid-phase extraction (LPE) utilizes the difference in solubility of substances in different solvents to transfer a specific component of a mixture to another solvent, achieving separation. The most common method is liquid-phase extraction using a separatory funnel. LPE involves adding a solvent or liquid reagent that is immiscible or only slightly miscible with the sample solution, mixing thoroughly in a separatory funnel, and then extracting the component from the mixture by utilizing the difference in solubility of the specific component in the two solvents, thus separating it from the mixture in the solvent with higher solubility.

[0134] In the embodiments, specifically, Viola yedoensis, in terms of its properties and channels, is bitter, pungent, and cold. It enters the heart and liver channels.

[0135] Efficacy: Clears heat and detoxifies, reduces swelling and dissipates nodules.

[0136] This product contains flavonoids and other compounds. It has inhibitory effects on Mycobacterium tuberculosis, Shigella dysenteriae, Staphylococcus aureus, Streptococcus pneumoniae, dermatophytes, and Leptospira. In addition, it has antipyretic, anti-edema, and anti-inflammatory effects.

[0137] [Modern Pharmacological Research] Viola yedoensis has antimicrobial activity: its decoction has inhibitory effects on Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi, Shigella dysenteriae, etc.; its alcohol extract and water extract can also kill Leptospira; its infusion has inhibitory effects on Trichophyton violaceum.

[0138] Viola yedoensis has anti-endotoxin effects.

[0139] Viola yedoensis has the effects of clearing heat, reducing swelling and inflammation, and also has anti-snake venom properties.

[0140] In the embodiments, specifically, Purple-backed Scutellaria baicalensis seeds, in terms of their properties and meridian tropism, are sweet and slightly sour in taste, and cool in nature.

[0141] Efficacy: Clears heat and detoxifies, moistens the lungs and relieves cough, disperses blood stasis and reduces swelling, promotes body fluid and quenches thirst.

[0142] This product, Purple-backed Amaranth, is a plant that can be used both as medicine and as a nutritional supplement.

[0143] Per 100g of leaves, there is 0.79g of water, 0.18g of crude fat, 2.11g of crude protein, 0.94g of crude fiber, 5644 IU of vitamin A, 0.01mg of vitamin B1, 0.13mg of vitamin B2, 0.78mg of vitamin C, 136.41mg of potassium, 89.66mg of calcium, 1.61mg of iron, 18.73mg of phosphorus, and 0.59mg of niacin. The tender stems, leaves, and shoots are higher in vitamin C and also contain flavonoids. Analysis shows that per 100g of dry matter, there are 1.4-3.0g of calcium, 0.17-0.39g of phosphorus, 1.34-2.52mg of copper, 20.97mg of iron, 2.60-7.22mg of zinc, and 0.47-14.87mg of manganese.

[0144] [Modern Pharmacological Research] Purple-backed amaranth is rich in minerals and nutrients, including trace elements such as calcium, manganese, iron, zinc, and copper.

[0145] Purple-backed amaranth contains flavonoids that have a moderate anti-malignant effect on cells, prolong the effect of ascorbic acid, and have anti-parasitic and antiviral effects.

[0146] Purple-backed amaranth is rich in iron, provitamin A, flavonoids, and manganese, an enzyme that promotes blood circulation, stops bleeding, detoxifies, and reduces swelling.

[0147] Purple-backed amaranth is rich in flavonoids, which can prolong the effect of vitamin C and reduce vascular purpura.

[0148] Purple-backed amaranth can enhance the body's resistance to parasites and viruses, and has a certain preventive effect against tumors.

[0149] Purple-backed amaranth has the effect of treating hemoptysis, metrorrhagia, dysmenorrhea, bronchitis, pelvic inflammatory disease and iron deficiency anemia.

[0150] In the embodiments, specifically, Wild chrysanthemum, in terms of its properties and meridian tropism, is bitter, pungent, and slightly cold. It enters the lung and liver meridians.

[0151] Efficacy: Clears heat and detoxifies.

[0152] This product contains a variety of active ingredients, including robinin-7-rhamnosylglucoside, wild chrysanthemum lactone, bitter substances, volatile oil, vitamin A and vitamin B1, amino acids, and trace elements.

[0153] [Modern Pharmacological Research] The aqueous extract of wild chrysanthemum has a significant protective effect on the cardiovascular system, increasing cardiac output, myocardial oxygen supply, and protecting the normal physiological function of ischemic myocardium.

[0154] The water extract of wild chrysanthemum and the blue-green volatile oil extracted by steam distillation have killing or inhibitory activities against pathogenic bacteria and viruses.

[0155] The water extract of wild chrysanthemum has stronger inhibitory activity against Staphylococcus aureus, Shigella dysenteriae, Escherichia coli, and Salmonella typhi than the volatile oil; it also has anti-inflammatory, antioxidant, and analgesic activities.

[0156] Wild chrysanthemum has a strong inhibitory effect on most skin fungi, Staphylococcus aureus, Shigella dysenteriae, Pseudomonas aeruginosa, and influenza virus.

[0157] Wild chrysanthemum has a significant blood pressure lowering effect.

[0158] Wild chrysanthemum has antibacterial and antiviral effects, and it has varying degrees of inhibitory effects on Staphylococcus aureus, Escherichia coli, Corynebacterium diphtheriae, Shigella dysenteriae, Pseudomonas aeruginosa, and Proteus mirabilis.

[0159] Wild chrysanthemum has the functions of clearing heat, anti-inflammation, oxidation, and improving the body's immunity. It also has a significant scavenging effect on superoxide anion free radicals.

[0160] In the embodiments, specifically, Forsythia, in terms of its properties and channels, is bitter and slightly cold. It enters the lung, heart, and gallbladder channels.

[0161] Efficacy: Clears heat and detoxifies, reduces swelling and dissipates nodules, and disperses wind-heat.

[0162] This product contains triterpenoid saponins, and the pericarp contains sterols, phenolic components (forsythoside), alkaloids, saponins, oleanolic acid, coumarins, as well as abundant vitamin P and a small amount of volatile oil.

[0163] Forsythia has broad-spectrum antibacterial effects, with strong inhibitory effects on Staphylococcus aureus and Shigella dysenteriae, and also has certain inhibitory effects on other pathogenic bacteria, influenza viruses, and fungi.

[0164] It has anti-inflammatory properties.

[0165] The oleanolic acid contained in this product has cardiotonic, diuretic, and blood pressure-lowering effects.

[0166] Vitamin P can reduce vascular permeability and fragility, and prevent hemolysis.

[0167] The decoction has antiemetic and anti-liver-damage effects.

[0168] [Modern Pharmacological Research] Forsythia has antimicrobial activity: In vitro tests show that the volatile oil emulsion of Forsythia seeds has inhibitory effects on both Gram-positive and Gram-negative bacteria, as well as on Candida albicans and Candida tropicalis, Jingke 68-1 virus, Sendai virus, and anti-Coxsackie B5 virus. A 100% concentration of Forsythia extract has an inhibitory effect on endotoxins, and its alcohol extract can also kill Leptospira.

[0169] Forsythia has significant anti-inflammatory effects.

[0170] Forsythia has antipyretic properties. Forsythia decoction or compound forsythia injection can lower body temperature in both artificially induced fever and normal animals.

[0171] Forsythia has effects on the cardiovascular system. Forsythia injection has cardiotonic and pressor effects on toxic shock in cats in vivo. It also significantly inhibits acetic acid-induced capillary permeability. Intravenous injection of 0.25 g / kg of 100% Forsythia injection can significantly lower the blood pressure of anesthetized dogs.

[0172] Forsythia has a liver-protective effect.

[0173] Forsythia has an antiemetic effect.

[0174] Forsythia also has diuretic and hemostatic effects.

[0175] In the embodiments, specifically, Astragalus root, in terms of its properties and channels, is sweet and slightly warm. It enters the spleen and lung channels.

[0176] Efficacy: Tonifies Qi and raises Yang, strengthens Wei Qi and consolidates the exterior, promotes diuresis and reduces swelling, and promotes tissue regeneration and wound healing.

[0177] It mainly contains glycosides, polysaccharides, amino acids, and trace elements.

[0178] It has the effects of enhancing the body's immune function, diuresis, anti-aging, liver protection, and lowering blood pressure.

[0179] It can eliminate proteinuria in experimental nephritis, enhance myocardial contractility, and also has estrogen-like effects and broad-spectrum antibacterial activity.

[0180] Astragalus saponin A has multiple effects, including lowering blood pressure, stabilizing red blood cell membranes, increasing the content of c-AMP in plasma tissues, enhancing immune function, and promoting the synthesis of regenerated liver DNA.

[0181] Astragalus polysaccharides have the effects of improving stress resistance in mice, enhancing immune function, regulating blood sugar levels, protecting the cardiovascular system, and accelerating the repair of bodies damaged by radiation.

[0182] [Modern Pharmacological Research] Astragalus can counteract the effects of immunosuppressive agents and enhance the functions of humoral immunity, cellular immunity, the reticuloendothelial system, and the exosome system. It can also induce the production of certain immune cytokines, induce interferon production, and enhance natural killer cells. It has a good regulatory effect on a variety of immune factors.

[0183] Astragalus has the effects of strengthening the heart, limiting or reducing the area of ​​myocardial infarction, improving the symptoms of myocarditis, resisting stress, and resisting myocardial ischemia. It can dilate blood vessels, dilate coronary arteries, lower blood pressure, and improve the metabolic balance of myocardial oxygen.

[0184] Astragalus can improve various blood rheological properties, inhibit platelet aggregation, prevent thrombosis, and enhance hematopoietic function.

[0185] Astragalus can enhance the physiological metabolism of cells, promote the synthesis of nucleic acids and proteins, and regulate blood glucose concentration in both directions.

[0186] Astragalus has anti-tumor effects.

[0187] Astragalus can increase collagen synthesis in tissues, prolong cell lifespan, and has antioxidant and anti-aging effects.

[0188] Astragalus has therapeutic effects on nephritis, renal failure, nephrotic syndrome, and chronic renal insufficiency. It also has an antagonistic effect on the nephrotoxicity of gentamicin and a diuretic effect.

[0189] Astragalus has a hypoglycemic effect and an antagonistic effect on hypothyroidism in aged rats.

[0190] Astragalus can enhance brain function, improve the learning and memory abilities of mice, and has analgesic and sedative effects.

[0191] Astragalus has a protective effect against experimental hepatitis and can enhance the tension of smooth muscles in the small intestine.

[0192] Astragalus has antibacterial and antiviral effects.

[0193] Astragalus membranaceus has a contractile effect on isolated rat uterus and an estrogen-like effect.

[0194] Astragalus has anti-radiation properties and protects the hematopoietic and immune systems.

[0195] Astragalus has a significant anti-fatigue effect.

[0196] In the embodiments, specifically, Fangfeng (Saposhnikovia divaricata) is pungent, sweet, and slightly warm in nature. It enters the bladder, liver, and spleen meridians.

[0197] Efficacy: It releases exterior wind, dispels dampness and relieves pain, stops spasms and diarrhea.

[0198] This product contains volatile oils, mannitol, bitter substances, acids, polysaccharides, and organic acids.

[0199] This product has antipyretic, anti-inflammatory, analgesic, and anticonvulsant effects. Fresh juice of Saposhnikovia divaricata has a certain antibacterial effect against Pseudomonas aeruginosa and Staphylococcus aureus, and the decoction has varying degrees of inhibitory effect on Shigella dysenteriae, hemolytic streptococci, etc.

[0200] [Modern Pharmacological Research] Fangfeng has sedative and anticonvulsant effects.

[0201] Saposhnikovia divaricata has antipyretic and analgesic effects.

[0202] Saposhnikovia divaricata has antibacterial and antiviral effects. A decoction of Saposhnikovia divaricata inhibits various cocci, Penicillium chrysogenum, and Aspergillus versicolor.

[0203] The decoction of Saposhnikovia divaricata also has inhibitory effects on Colombian SK virus and Trichophyton mentagrophytes. In chicken embryo experiments, the decoction of Saposhnikovia divaricata showed inhibitory effects on influenza A3 virus.

[0204] Saposhnikovia divaricata has anti-inflammatory and anti-allergic effects.

[0205] Effects of Saposhnikovia divaricata on the immune system: Oral administration of Saposhnikovia divaricata to mice for 4 days enhanced the phagocytic function of peritoneal macrophages.

[0206] Saposhnikovia divaricata has anticoagulant properties. The n-butanol extract of Saposhnikovia divaricata has the effect of prolonging clotting and bleeding time in mice.

[0207] In the embodiments, specifically, Reed rhizome, in terms of its properties and channels, is sweet and cold. It enters the lung and stomach channels.

[0208] Efficacy: Clears heat and promotes the production of body fluids, relieves irritability and stops vomiting.

[0209] This product contains coixol, asparagine, etc. In vitro experiments have shown it to inhibit β-hemolytic streptococci.

[0210] [Modern Pharmacological Research] Reed rhizome has a weak central nervous system depressant effect, manifested as a sedative effect in rats and mice, and can antagonize the effects of caffeine. In the electroencephalograms of rabbits, it shows increased amplitude and decreased frequency.

[0211] Reed rhizome has antipyretic and analgesic effects.

[0212] Reed rhizome has an inhibitory effect on skeletal muscle. The coixol contained in reed rhizome can inhibit the contraction response caused by electrical stimulation of frog neuromuscular specimens, as well as oxygen uptake and glycolysis of rat diaphragm, and can inhibit the response of the actin-adenosine triphosphate system.

[0213] Reed rhizome has the effect of relaxing intestinal smooth muscle. The alfalfa extract it contains has a relaxing effect on isolated guinea pig intestine. At a concentration of 2×10-5, it can significantly inhibit the contraction of isolated rabbit small intestine. Injecting 4mg into the rabbit small intestinal lumen can slow down peristaltic contraction.

[0214] Reed rhizome has antibacterial properties; a 100% decoction of reed rhizome has varying degrees of inhibitory effects on polycocci and bacilli.

[0215] Reed rhizome has antioxidant, antiemetic, and anticancer effects. It can also dissolve gallstones and detoxify fish, crabs, and pufferfish.

[0216] In the embodiments, specifically, Houttuynia cordata, in terms of its properties and meridian tropism, is pungent and slightly cold. It enters the Lung meridian.

[0217] Efficacy: Clears heat and detoxifies, eliminates carbuncles and drains pus, promotes urination and relieves strangury.

[0218] This product contains houttuynia cordata, volatile oil, houttuynia cordata alkaloid, quercetin, potassium chloride, etc. Houttuynia cordata has varying degrees of inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Salmonella typhi, and Mycobacterium tuberculosis; it can enhance the phagocytic capacity of leukocytes and improve the body's immunity; it also has anti-inflammatory effects. The quercetin and potassium salts it contains can dilate the renal artery and increase renal blood flow, thus having a strong diuretic effect. In addition, it also has analgesic, hemostatic, and antitussive effects.

[0219] [Modern Pharmacological Research] Houttuynia cordata has antibacterial, antiviral, and anti-leptospiral effects.

[0220] Houttuynia cordata decoction has inhibitory effects on various Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, hemolytic streptococci, Streptococcus pneumoniae, Corynebacterium diphtheriae, Proteus vulgaris, Shigella dysenteriae, Shigella flexneri, Shigella sonnei, Enterobacter spp., and Clostridium choleraesuis. It also inhibits hepatitis A virus and Asian influenza A virus strain 68-1, and can delay cytopathic effects of ECHO11 virus (orphan virus). Houttuynia cordata distillate has a direct inhibitory effect on HSV-1, influenza virus, and HIV. An oily substance extracted from Houttuynia cordata inhibits the growth of many microorganisms, particularly yeast and mold.

[0221] Houttuynia cordata has the effect of enhancing the body's immune function. In vitro, Houttuynia cordata decoction can significantly promote the ability of human peripheral leukocytes to phagocytose Staphylococcus aureus.

[0222] Houttuynia cordata has certain anti-cancer effects.

[0223] Houttuynia cordata has anti-allergic and anti-asthmatic effects.

[0224] Houttuynia cordata has anti-inflammatory properties.

[0225] Houttuynia cordata has a diuretic effect; it can dilate blood vessels in toads, increasing blood flow and urine secretion.

[0226] Houttuynia cordata also has sedative, hemostatic, serous secretion-inhibiting, and tissue regeneration-promoting effects.

[0227] In the embodiments, specifically, Agrimonia pilosa, in terms of its properties and channels, is bitter, astringent, and neutral. It enters the lung, liver, and spleen channels.

[0228] Efficacy: Astringent and hemostatic, tonifying, digestive, anti-dysentery, and insecticidal.

[0229] This product contains agrimony extract, agrimonol, agrimonol lactone, agrimonol, tannins, volatile oils, vitamins C and K, etc. Early reports indicated that agrimony extract had procoagulant effects, while recent reports suggest it has anticoagulant effects; it also has antibacterial and anti-trichomonal effects, killing effects on tapeworms, roundworms, and schistosomes, and antimalarial effects; it inhibits cancer cells; and it can regulate heart rate and lower blood sugar.

[0230] Take 30-50 grams, grind into powder and swallow, once a day, on an empty stomach in the morning. It is not suitable for decoction, as the active ingredients are almost insoluble in water.

[0231] Agrimony has an astringent taste and functions to stop bleeding; it is widely used for bleeding disorders in various parts of the body. Agrimonia pilosa has the effect of stopping malaria and treating malaria with chills and fever. Agrimony has an astringent taste and can stop diarrhea. Because of its mild medicinal properties, it can both tonify and stop bleeding, making it particularly effective for bloody dysentery and chronic diarrhea.

[0232] Agrimony has detoxifying, insecticidal, and antipruritic properties, and can be used to treat vulvar itching and leukorrhea. Agrimony has a tonic and strengthening effect, and can be used to treat exhaustion and fatigue caused by overexertion, with symptoms such as fatigue and weakness. Hot water or ethanol extracts of Agrimonia pilosa showed inhibitory effects on Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Shigella flexneri, and Salmonella typhi in vitro.

[0233] It also has an inhibitory effect on human tuberculosis. The whole herb water extract and water-alcohol extract have anti-inflammatory effects on conjunctivitis in rabbits caused by mustard oil or Staphylococcus aureus infection.

[0234] Both the infusion and agrimony extract have cardiotonic effects on isolated frog hearts, increasing heart rate and contractile strength in frogs and toads. However, the ethanol extract of the water-derived fraction has an inhibitory effect on isolated frog hearts. Intravenous injection of the agrimony ethanol extract into anesthetized rabbits and dogs increases blood pressure. The ethanol extract of the water-derived fraction decreases blood pressure in rabbits. Perfusion of the hind limb vessels of rabbits and frogs at low concentrations causes vasoconstriction, while at high concentrations it causes vasodilation. Perfusion of the agrimony infusion and water extract into rabbit ear vessels has no effect at low concentrations, but a dilating effect at high concentrations, and can counteract the vasoconstrictive effect of adrenaline.

[0235] The ethanol extract of the water-extracted fraction showed stimulating effects on isolated rabbit and guinea pig intestines at low concentrations, while inhibiting them at high concentrations. Agrimonia pilosa lactone reduced the contraction amplitude and tension of isolated rabbit intestines, subsequently causing intestinal motility to cease in a relaxed state; it also inhibited peristalsis in in situ rat small intestines. The infusion had an adrenaline-like effect on isolated rabbit and guinea pig uteruses.

[0236] In the embodiments, specifically, Patrinia scabiosifolia, in terms of its properties and channels, is pungent, bitter, and slightly cold. It enters the stomach, large intestine, and liver channels.

[0237] Efficacy: Clears heat and detoxifies, eliminates carbuncles and drains pus, removes blood stasis and relieves pain.

[0238] The roots and rhizomes of *Patrinia scabra* contain oleanolic acid, hederagenin, various saponins, as well as volatile oils, alkaloids, tannins, etc. *Patrinia scabra* contains volatile oils, and its dried fruiting branches contain sinigrin, etc.; its roots and rhizomes contain morodinin, strychnine, and patrinin.

[0239] Patrinia scabiosifolia has inhibitory effects on Staphylococcus aureus, Shigella dysenteriae, Salmonella typhi, Pseudomonas aeruginosa, and Escherichia coli; and also has antiviral effects.

[0240] It can promote liver cell regeneration, prevent liver cell degeneration, and improve liver function.

[0241] Extensive use can cause temporary leukopenia, dizziness, and nausea.

[0242] The ethanol extract or volatile oil of Patrinia scabiosifolia has a significant sedative effect.

[0243] [Modern Pharmacological Research] Patrinia scabiosifolia has antibacterial and antiviral effects. Infusions and oral solutions of Patrinia scabiosifolia have varying degrees of inhibitory effects on various cocci and bacilli. In cell culture, Patrinia scabiosifolia has inhibitory effects on respiratory syncytial virus, Coxsackie B1, and B4 viruses. It also has an inhibitory effect on influenza virus in chicken embryos.

[0244] Patrinia scabiosifolia has hepatoprotective and choleretic effects. Studies have shown that it significantly promotes hepatocyte regeneration and prevents hepatocyte degeneration and necrosis. The whole plant also lowers the levels of thymol, phospholipids, cholesterol, and alanine aminotransferase. Therefore, it is believed to have anti-hepatitis virus effects, can reduce hepatitis lesions, and clear capillary bile ducts.

[0245] Patrinia scabiosifolia has a calming effect, and its active ingredient is saponin.

[0246] Patrinia scabiosifolia has anti-tumor effects.

[0247] In the embodiments, specifically, Salvia miltiorrhiza, in terms of its properties and channels, is bitter and slightly cold. It enters the heart and liver channels.

[0248] Efficacy: Promotes blood circulation and regulates menstruation, cools the blood and reduces swelling, calms the mind.

[0249] This product contains fat-soluble non-quinone components: tanshinone I, IIA, IIIB, cryptotanshinone, dihydrotanshinone, etc.; and water-soluble components: protocatechuic aldehyde, protocatechuic acid, tanshinone, vitamin E, etc.

[0250] Danshen can dilate coronary arteries, increase coronary blood flow, improve myocardial ischemia, infarction and cardiac function, regulate heart rhythm, and dilate peripheral blood vessels to improve microcirculation; It has anticoagulant, fibrinolytic, platelet aggregation inhibitory, and thrombus-inhibiting effects; It can lower blood lipids and inhibit the formation of experimental coronary artery atherosclerotic plaques in rabbits; It can inhibit or reduce hepatocyte degeneration, necrosis and inflammatory response, promote hepatocyte regeneration, and has anti-fibrotic effects; It can improve the body's tolerance to hypoxia; It can promote tissue repair, accelerate fracture healing, shorten the recovery period of red blood cells and hemoglobin, and increase the number of reticulocytes; It has an inhibitory effect on a variety of bacteria and Mycobacterium tuberculosis.

[0251] It has an inhibitory effect on the central nervous system.

[0252] It also has immune-boosting, blood sugar-lowering, and anti-tumor effects.

[0253] [Modern Pharmacological Research] Danshen has significant anti-thrombotic and anti-atherosclerotic effects.

[0254] Low concentrations of Danshen (Salvia miltiorrhiza) have a certain inhibitory effect on isolated animal hearts. Sodium tanshinone IIA sulfonate slightly increased cardiac output in anesthetized dogs. Compound Danshen injection has a protective effect against myocardial ischemia induced by posterior pituitary extract, accelerating the repair of myocardial ischemia or damage and reducing the severity of acute myocardial ischemia. Danshen also has a significant effect on dilating coronary arteries and increasing coronary blood flow.

[0255] Danshen decoction, Danshen injection, compound Danshen injection, white-flowered Danshen injection, and Danshen leaf injection all have varying degrees of antihypertensive effects. Danshen and its injections have different effects on improving microcirculatory disorders in different animals, and also improve nailfold microcirculatory disorders in patients with coronary heart disease. Tanshinone IIA sodium sulfonate has a significant protective effect on canine erythrocyte morphology.

[0256] Tanshinone IIA has a significant protective effect on the morphology of canine erythrocytes, improving their oxygen-carrying capacity. Tanshinone IIA also exhibits tolerance to normobaric hypoxia.

[0257] Danshen (Salvia miltiorrhiza) has a protective effect against CCl4-induced acute liver injury and cirrhosis. Danshen injection significantly promotes DNA synthesis in hepatocytes in vitro.

[0258] Danshen injection has a protective effect against pulmonary fibrosis and lung injury, and can also alleviate the symptoms of acute respiratory distress syndrome.

[0259] Danshen decoction can inhibit various bacteria; among them, tanshinone ether extract and total tanshinone have strong inhibitory effects on Staphylococcus aureus and drug-resistant Staphylococcus aureus. 2% tanshinone suspension has anti-inflammatory effects.

[0260] Danshen injection can significantly reduce the phagocytic index of macrophages; it has a synergistic effect when used in combination with cyclophosphamide.

[0261] Danshen has an inhibitory effect on the central nervous system, and this effect is selective and increases with increasing dosage; it can also enhance learning and memory.

[0262] Danshen has anti-gastric ulcer, skin wound and fracture healing effects; it can play a significant protective role against renal failure; it can increase the estradiol content in immature rats and increase uterine weight.

[0263] In the embodiments, specifically, Poria cocos, in terms of its properties and channels, is sweet, bland, and neutral. It enters the heart, spleen, and kidney channels.

[0264] Efficacy: Promotes diuresis and eliminates dampness, strengthens the spleen and calms the mind.

[0265] Poria cocos contains pachyman, pachymic acid, protein, fat, lecithin, choline, histamine, ergosterol, etc. Poria cocos has a diuretic effect, increasing the excretion of electrolytes such as potassium, sodium, and chloride in urine. In addition, it also has sedative and blood sugar-lowering effects.

[0266] [Modern Pharmacological Research] Poria cocos has a diuretic effect, but the diuretic effect of a single herb is not as long-lasting as that produced by a compound formula.

[0267] Poria cocos can lower alanine aminotransferase (ALT) and prevent hepatocyte necrosis, thus achieving a liver-protective effect.

[0268] Poria cocos has a sedative effect.

[0269] Poria cocos polysaccharide and carboxymethyl poria cocos polysaccharide have varying degrees of inhibitory effects on various tumor cancer cells; the combination of poria cocos polysaccharide and chemotherapeutic drugs such as cyclophosphamide has a strong inhibitory effect on sarcoma S180.

[0270] Poria cocos polysaccharides can enhance macrophage function, significantly increase the number of antibody-secreting cells in the spleen of mice, and enhance immune function.

[0271] The aqueous, ethanol, or ether extracts of Poria cocos have cardiotonic effects, but their aqueous extracts or tinctures have inhibitory effects at high concentrations. Poria cocos alcohol and aqueous extracts can increase myocardial nutritional blood flow.

[0272] Poria cocos also has anti-ulcer, antibacterial, hypoglycemic, relaxing effects on isolated intestinal segments, and leptospirosis-killing effects.

[0273] In the embodiments, specifically, Curcuma zedoaria, in terms of its properties and channels, is pungent, bitter, and warm. It enters the liver and spleen channels.

[0274] Efficacy: Promotes blood circulation, relieves stagnation and pain.

[0275] This product contains volatile oil, mainly composed of turmericone, turmericene, and curcumin. In recent years, turmeric alcohol and turmeric diketone, effective anticancer components, have also been isolated from the volatile oil. It has anticancer effects; in addition to its direct action, it can enhance the host's specific immune function, thus achieving a significant immune protective effect. Curcumin can inhibit platelet aggregation and has an antithrombotic effect. It can stimulate gastrointestinal smooth muscle. Turmeric alcohol and its semiterpenoid compounds have significant anti-early pregnancy effects. The volatile oil can inhibit Staphylococcus aureus, beta-hemolytic streptococci, Escherichia coli, Cholera bacillus, and Vibrio cholerae.

[0276] [Modern Pharmacological Research] Curcuma zedoaria has a certain antithrombotic effect.

[0277] Curcuma zedoaria volatile oil has the effect of killing cancer cells; curcumin has the effect of inhibiting tumors; curcuma zedoaria oil can enhance the host's specific immunity through the immune system and obtain a significant immune protection effect; at the same time, it also has a radiosensitizing and tumor-inhibiting effect.

[0278] The volatile oil of Curcuma zedoaria can increase the secretion of digestive juices to aid digestion and has a significant therapeutic effect on various gastric ulcers.

[0279] Curcuma zedoaria, its alcoholic extract, and sesquiterpene compounds have significant anti-early pregnancy and anti-implantation effects.

[0280] In vitro experiments have shown that Curcuma zedoaria has an inhibitory effect on a variety of cocci and bacilli.

[0281] Curcuma oil also has anti-inflammatory properties.

[0282] Curcuma oil and curcumol have a significant protective effect on leukocytes.

[0283] In the embodiments, specifically, Reishi mushroom, in terms of its properties and channels, is sweet and neutral. It enters the kidney, liver, heart, and lung channels.

[0284] The Classic of Materia Medica states: "Sweet and warm."

[0285] The *Bielu* states: "Non-toxic."

[0286] The Treatise on the Properties of Medicinal Herbs states: "It is sweet, neutral, and non-toxic."

[0287] Efficacy: Nourishes essence, tonifies the kidneys, and dispels wind.

[0288] Purple Ganoderma contains ergosterol, organic acids (cis-ricinoleic acid, fumaric acid, etc.), glucosamine, polysaccharides, resins, mannitol, etc. Red Ganoderma contains ergosterol, resins, fatty acids, mannitol, and polysaccharides, as well as alkaloids, lactones, coumarins, water-soluble proteins, and various enzymes.

[0289] In the embodiments, specifically, Fritillaria cirrhosa, in terms of its properties and channels, is bitter, sweet, and slightly cold. It enters the lung and heart channels.

[0290] Efficacy: Clears heat and resolves phlegm, moistens the lungs and relieves cough, disperses nodules and reduces swelling.

[0291] This product contains various alkaloids, such as fritillary alkaloid, citronella alkaloid, citronella alkaloid, citronella alkaloid, and pine pine alkaloid.

[0292] Both the total alkaloids and non-alkaloids of Fritillaria cirrhosa have antitussive effects; Fritillaria cirrhosa fluid extract and Fritillaria cirrhosa alkaloids have expectorant effects to varying degrees.

[0293] Fritillaria cirrhosa also has antispasmodic effects.

[0294] Intravenous injection of fritillary alkaloids in cats has a hypotensive effect and causes transient respiratory depression. Fritillary alkaloids also have a hypotensive effect in anesthetized dogs.

[0295] Fritillary alkaloids can increase the tension of isolated guinea pig uteri.

[0296] The total alkaloids of Fritillaria have anti-ulcer effects.

[0297] [Modern Pharmacological Research] Fritillaria has antitussive and expectorant effects.

[0298] Fritillaria has a blood pressure-lowering effect.

[0299] Intravenous injection of fritillaria alkaloids into rabbits can cause a sustained increase in blood sugar levels that lasts for more than 2 hours.

[0300] Fritillaria has a relaxing effect on intestinal smooth muscle, and its active ingredient is cisperidin.

[0301] Fritillaria has antibacterial properties. The alcoholic extract of Fritillaria cirrhosa inhibits the growth and reproduction of Escherichia coli and Staphylococcus aureus, while the aqueous extract of Fritillaria cirrhosa inhibits Nocardia asteroides in vitro.

[0302] Fritillaria has the ability to tolerate hypoxia.

[0303] Fritillaria can accelerate the flow of mucus from the tracheal cilia.

[0304] Fritillaria has anti-vasoconstrictive effects, and the cisperidin contained in Fritillaria has significant anti-vasoconstrictive, myocardial nourishing, and coronary artery dilating effects.

[0305] In the embodiments, specifically, Atractylodes macrocephala, in terms of its properties and channels, is bitter, sweet, and warm. It enters the spleen and stomach channels.

[0306] Efficacy: Tonifies Qi and strengthens the spleen, dries dampness and promotes diuresis, stops sweating, and calms the fetus.

[0307] Atractylodes macrocephala contains volatile oil, the main components of which are atractylone, atractylolactone A and B, and sugars (mainly mannose and fructose). Atractylodes macrocephala has tonic, diuretic, hypoglycemic, and anticoagulant effects, and can protect the liver and prevent the reduction of liver glycogen caused by carbon tetrachloride.

[0308] [Modern Pharmacological Research] Atractylodes macrocephala has hepatoprotective and choleretic effects, and it has a significant inhibitory effect on experimental gastric ulcers and stress-induced gastric ulcers, as well as a significant regulatory effect on intestinal motility.

[0309] Atractylodes macrocephala has a significant and long-lasting diuretic effect.

[0310] Atractylodes macrocephala can enhance the phagocytic function of the reticuloendothelial system, promote cellular immune function, increase the content of IgG in serum, and also increase white blood cell count when leukopenia occurs.

[0311] Atractylodes macrocephala volatile oil has significant anti-tumor effects and can enhance the antigenicity of cancer cells and the specific active immunity of antibodies.

[0312] Atractylodes macrocephala has an inhibitory effect on the heart, dilates vascular smooth muscle to lower blood pressure, and has sedative and respiratory stimulant effects.

[0313] Atractylodes macrocephala can lower blood sugar and has a significant inhibitory effect on the reduction of platelets.

[0314] Atractylodes macrocephala has varying degrees of inhibitory effects on a variety of bacteria. Extracts of Atractylodes macrocephala have anti-inflammatory and antipyretic effects.

[0315] Atractylodes macrocephala has a significant inhibitory effect on uterine smooth muscle in rabbits, guinea pigs, mice, and rats.

[0316] Atractylodes macrocephala volatile oil has analgesic effects.

[0317] Atractylodes macrocephala has a significant tonic effect.

[0318] In the embodiments, specifically, Antimicrobial activity: Antibacterial: The ingredients in the formula, such as Coptis chinensis (containing berberine), Scutellaria baicalensis (containing baicalin), Phellodendron chinense, Lonicera japonica, Taraxacum mongolicum, Forsythia suspensa, Patrinia scabiosaefolia, and Houttuynia cordata, have significant in vitro inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, hemolytic streptococci, Neisseria gonorrhoeae, Escherichia coli, Shigella dysenteriae, and Treponema pallidum.

[0319] Antiviral effects: Coptis chinensis, Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Houttuynia cordata have significant inhibitory effects on influenza virus, herpes simplex virus (HSV), and Coxsackie virus. Houttuynia cordata distillate has a direct inhibitory effect on HSV-1 and HIV.

[0320] Antiparasitic: Coptis chinensis, Phellodendron chinense, Agrimonia pilosa, etc. have inhibitory or killing effects on Trichomonas vaginalis, amoebae, etc.

[0321] Immunomodulatory effects: Astragalus can enhance the body's immune function, promoting both humoral and cellular immunity. It can also induce interferon production and enhance the activity of natural killer cells (NK cells).

[0322] Poria cocos polysaccharides and Ganoderma lucidum polysaccharides can significantly enhance the phagocytic function of macrophages, promote antibody production, and improve the body's immunity.

[0323] Honeysuckle, dandelion, and other plants can also promote the phagocytic function of white blood cells.

[0324] Anti-inflammatory, antipyretic, and analgesic effects: Scutellaria baicalensis, Gardenia jasminoides, Salvia miltiorrhiza, and Saposhnikovia divaricata all have significant anti-inflammatory effects, which can inhibit the increase of capillary permeability and inhibit the release of inflammatory mediators.

[0325] Coptis chinensis, Scutellaria baicalensis, Lonicera japonica, Taraxacum mongolicum, and Phragmites communis have clear antipyretic and analgesic effects, and can effectively relieve symptoms such as fever and pain caused by sexually transmitted diseases.

[0326] Improves circulation and promotes tissue repair: Danshen can dilate coronary arteries and peripheral blood vessels, improve microcirculation, prevent thrombosis, and promote blood supply and tissue repair at the lesion site.

[0327] Curcuma zedoaria can break up blood stasis, promote qi circulation, eliminate stagnation, and relieve pain. Its volatile oil has anti-inflammatory and tissue regeneration-promoting effects.

[0328] Other beneficial effects: Liver-protective effects: Coptis chinensis, Scutellaria baicalensis, Gardenia jasminoides, Salvia miltiorrhiza, Poria cocos, etc., all have the effects of protecting the liver and lowering enzymes, promoting liver cell regeneration, and preventing liver damage, which can reduce the damage to the liver caused by drugs or diseases.

[0329] Anti-tumor effects: The active substances in ingredients such as Coptis chinensis, Astragalus membranaceus, Curcuma zedoaria, and Ganoderma lucidum have inhibitory effects on certain tumor cells and may have a positive preventive effect on the risk of cervical cancer caused by HPV.

[0330] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in the present invention, and these should all be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A traditional Chinese medicine preparation formula for treating infectious diseases, characterized in that, Made from the following parts by weight of active pharmaceutical ingredient: Coptis chinensis 5-15 parts, Scutellaria baicalensis 5-15 parts, Phellodendron chinense 5-15 parts, Gardenia jasminoides 5-15 parts, Lonicera japonica 10-20 parts, Taraxacum mongolicum 10-20 parts, Chrysanthemum morifolium 5-15 parts, Viola yedoensis 5-15 parts, Semiaquilegia adoxoides 5-15 parts, Houttuynia cordata 10-20 parts, Agrimonia pilosa 5-15 parts, Patrinia scabiosaefolia 5-15 parts, Forsythia suspensa 5-15 parts, Astragalus membranaceus 10-30 parts, Saposhnikovia divaricata 5-10 parts, Phragmites communis 5-15 parts, Salvia miltiorrhiza 5-15 parts, Poria cocos 5-15 parts, Curcuma zedoaria 5-10 parts, Ganoderma lucidum 5-15 parts, Atractylodes macrocephala 5-15 parts, and Fritillaria cirrhosa 5-10 parts.

2. The traditional Chinese medicine preparation formula for treating infectious diseases according to claim 1, characterized in that, The weight parts of each active pharmaceutical ingredient are as follows: Coptis chinensis 10 parts, Scutellaria baicalensis 10 parts, Phellodendron chinense 10 parts, Gardenia jasminoides 10 parts, Lonicera japonica 15 parts, Taraxacum mongolicum 15 parts, Chrysanthemum morifolium 10 parts, Viola yedoensis 10 parts, Semiaquilegia adoxoides 10 parts, Houttuynia cordata 15 parts, Agrimonia pilosa 10 parts, Patrinia scabiosaefolia 10 parts, Forsythia suspensa 10 parts, Astragalus membranaceus 20 parts, Saposhnikovia divaricata 8 parts, Phragmites communis 10 parts, Salvia miltiorrhiza 10 parts, Poria cocos 10 parts, Curcuma zedoaria 8 parts, Ganoderma lucidum 10 parts, Atractylodes macrocephala 10 parts, and Fritillaria cirrhosa 8 parts.

3. The method for preparing a traditional Chinese medicine preparation for treating infectious diseases according to claim 1 or 2, characterized in that, Includes the following steps: S1. Pretreatment and drying: Mix the raw materials according to the formula and dry them according to their categories; S2. Crushing and Screening: The large pieces of raw material after drying are initially crushed and then screened by screening machines of different mesh sizes to remove particles and foreign objects that do not meet the standards. S3. Low-temperature grinding: The screened raw materials are placed in a cryogenic grinder and cooled to -196°C with liquid nitrogen for mechanical grinding until ultrafine powder with a central particle size of less than 5-10μm is obtained, thereby achieving cell wall disruption. S4. Compound extraction: Add the ultrafine powder to the extraction tank, add 5-10 times the amount of purified water or 50-75% ethanol, and reflux extract at 25-40℃ 2-3 times, 1-2 hours each time. Combine the extracts, filter, and obtain the filtrate. S5. Bio-fermentation: Inoculate the extract with probiotics or yeast and ferment for 4-72 hours at a pH of 5.5-6.5 and a temperature of 38-45℃ to enhance the active ingredients and improve bioavailability. S6. Instant sterilization: The temperature of the fermented extract is rapidly raised to 121°C, maintained for 15 seconds, and then rapidly cooled to 50°C. This process can kill 98% of bacteria or microorganisms while preserving the activity of the medicinal materials to the greatest extent. S7. Low-temperature concentration: The sterilized extract is concentrated at a low temperature of 50°C until the finished product is obtained.

4. The method for preparing a traditional Chinese medicine preparation for treating infectious diseases according to claim 3, characterized in that: In S1, drying is carried out according to category, including drying flowers, leaves, and whole herbs at 20-30℃; drying rhizomes at 30-65℃; drying fruits at 70-90℃; drying those containing volatile oils at 25-30℃; and drying those containing glycosides and alkaloids at 50-60℃.

5. The method for preparing a traditional Chinese medicine preparation for treating infectious diseases according to claim 3, characterized in that: The low-temperature grinding described in S3 uses liquid nitrogen to make the plant cell walls and contents brittle and lose their toughness, thereby breaking the cell walls under mechanical force. At the same time, the low-temperature environment inhibits the activity of enzymes and chemical reactions, protecting heat-sensitive and easily oxidized components.

6. The method for preparing a traditional Chinese medicine preparation for treating infectious diseases according to claim 3, characterized in that: The bio-fermentation described in S5 is a biotransformation process that uses microorganisms or their enzymes to decompose plant raw materials under specific conditions in order to change or enhance their active ingredients, produce new substances, or improve their properties.