Targeted controlled-release drug delivery system based on polymer nano-carrier and preparation method of targeted controlled-release drug delivery system

By constructing a three-layer polymer nanocarrier system, combined with targeting aptamers and microenvironment-responsive peptides, the challenges of insufficient drug loading and release rate control in drug delivery systems for tumor treatment were solved. This enabled precise drug release and stable delivery to the tumor site, improving therapeutic efficacy and reducing toxicity.

CN121243424APending Publication Date: 2026-01-02GUANGZHOU LANGCAI BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511810505.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-03
Publication Date
2026-01-02

AI Technical Summary

Technical Problem

Existing polymer nanoparticle systems suffer from limitations in drug delivery, including limited drug loading capacity, difficulty in precisely controlling release rate, low targeting efficiency, and insufficient stability in complex pathological microenvironments. In particular, they lack multi-layered synergistic mechanisms and have poor response specificity in tumor treatment.

Method used

A three-layer structure based on polymer nanocarriers, including a core layer, a shell layer, and an outer shell layer, was constructed. Combined with tumor membrane targeting aptamers and microenvironment-responsive peptides, the precise identification and controlled release of drugs at tumor sites were achieved.

Benefits of technology

It improves the ability of drugs to accumulate and release in a controlled manner at the lesion site, enhances the therapeutic effect and reduces systemic toxicity, and demonstrates high efficiency and stability in a simulated tumor microenvironment.

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Abstract

The invention belongs to the technical field of biomedical materials and targeted drug delivery systems, and discloses a targeted controlled-release drug delivery system based on a polymer nano-carrier and a preparation method thereof.The system is of a three-layer structure and comprises a core layer formed by taking polyvinyl alcohol as a matrix and used for efficiently entrapping a drug, and an outer layer formed by taking polyvinyl alcohol as a matrix and used for efficiently entrapping the drug; the shell layer formed by the polylactic acid-glycolic acid copolymer is used for providing structural stability and slow release capability, and the shell layer formed by the polyvinyl alcohol-hydroformylated glucan grafted copolymer is used for realizing microenvironment response release. And the surface of the shell layer is covalently modified with a tumor membrane targeting aptamer and a microenvironment response peptide, so that accurate recognition and local trigger release can be realized. The system has good particle size stability, responsive release ability and tumor cell targeted enrichment effect, and is suitable for efficient delivery and controlled release of various antitumor drugs.
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