Stamp type microneedle

Abstract

The present invention is characterized by comprising: a main body; a pressing part formed to protrude from the upper end of the main body; a drug cartridge which is detachably coupled to the pressurizing part; a substrate part which is disposed between the drug cartridge and the pressurizing part and forms a plurality of needle parts; and a cover which is detachably coupled to the main body in a state in which the drug cartridge and the pressurizing unit are accommodated. The needle part formed on the base plate part is bent by the pressurizing force transmitted from the pressurizing part and protrudes to the upper part of the drug cartridge.

Description

Technical Field

[0001] This invention relates to a stamp-type microneedle, and more particularly to a stamp-type microneedle that can conveniently and effectively deliver high volumes of active ingredients or drugs by being inserted into the user's skin, while also improving skin absorption. Background Technology

[0002] Generally speaking, methods for delivering active ingredients or drugs into the body include taking the drug orally, injecting the drug, or absorbing the drug through the skin.

[0003] In the methods described above, oral administration, i.e., taking the drug, may cause central nervous system side effects such as headache, drowsiness, dizziness, and nervousness, as well as serious gastrointestinal side effects such as nausea, indigestion, diarrhea, peptic ulcers, gastrointestinal bleeding, and perforation. Therefore, it is limited to use as a short-term therapy.

[0004] In addition, the method of injecting drugs involves inserting a needle into the skin to inject the drug directly into the body, which has the advantage of rapid absorption. However, it has the inconvenience of requiring professional personnel to administer the medication (making it difficult to administer the medication to oneself), and the problem of poor patient compliance due to the pain caused by the use of needles with a diameter of several millimeters.

[0005] To address the side effects and drawbacks mentioned above, drug delivery systems utilizing transdermal delivery are being actively developed.

[0006] Generally, medications absorbed through the skin are formulated into forms such as liquids, creams, and gels. However, liquids, creams, and gels are difficult to use in terms of dosage due to their formulation characteristics, and they also have problems with stickiness and the potential for foreign matter contamination. In addition, most medications have the problem that only a very small amount is absorbed, while the majority evaporates.

[0007] Therefore, a method of delivering drugs is adopted by applying patches containing active ingredients or medications to the skin.

[0008] The use of patches allows medication to be absorbed through the skin, thus preventing gastrointestinal problems and food-related effects caused by oral medications. It also eliminates the pain and inconvenience of injections, and its convenience has led to its increasing use recently.

[0009] However, the use of patches has the problem of low drug absorption rates through the skin. That is, the biggest drawback of patches is that, due to the low absorption rate through the skin, the skin's function as a permeability barrier must be reduced. Typically, the absorption rate of drugs through patches is around 20%. Currently, methods to improve absorption rates include chemical methods such as using skin absorption enhancers and pre-treatment drugs, as well as physical methods such as iontophoresis and electrophoresis.

[0010] However, even when using the known methods described above, there are still limitations in improving drug absorption to a satisfactory level, so in order to achieve the desired efficacy, it is necessary to use an excessive amount of drug based on its absorption rate.

[0011] In particular, the type of skin absorption enhancer is determined by the design of the formulation or the physicochemical properties of the constituent components required for use, and a certain level of concentration is required to achieve the desired effect. However, when skin absorption enhancers are added, it is difficult to prevent crystallization over time, and there are also problems such as changes in adhesive properties such as adhesion and cohesion that make them unsuitable for use.

[0012] Furthermore, the use of electricity requires the patch to be equipped with batteries, electrodes, circuits, and other components, which complicates the product's structure. Its larger size also increases the price, and it generates a large amount of waste after use.

[0013] Therefore, in order to improve the skin absorption rate of active ingredients or drugs, molten polymer microneedles loaded with active ingredients or drugs have been developed. However, their drug loading capacity is relatively small, and the skin penetration efficiency of the microneedles is reduced due to the strength limitation of the polymer. Furthermore, when the microneedles are attached to the skin, they may break when attached along an inclined surface rather than a vertical direction. Therefore, commercialization remains a challenge.

[0014] To address the issues mentioned above, a method is proposed that involves forming and arranging multiple microneedles on a thin bioabsorbent metal plate containing ingredients beneficial to the human body, and then attaching it to the skin.

[0015] However, as a condition for maximizing the delivery of active ingredients or drugs, there is a problem that the microneedles are difficult to form and arrange within the limited planar area of ​​a metal plate.

[0016] Furthermore, there is a problem that the metal plate attached to the skin can easily detach from the skin due to the user's movement. Therefore, a solution using an adhesive patch to prevent the metal plate from detaching from the skin has been proposed. However, since the adhesive patch and the metal plate need to be firmly attached to the skin for a certain period of time, it causes psychological burden on the user.

[0017] Furthermore, because microneedles are formed on extremely thin metal plates, they are prone to breakage or bending when inserted into the skin.

[0018] Therefore, the applicant developed this invention to solve the problems described above, and as a related prior art document, it includes U.S. Patent Publication No. 2007-0293815, "Microprojection array application with sculptured microprojections for high drug loading". Summary of the Invention

[0019] The present invention aims to solve the existing problems described above by providing a stamp-type microneedle that allows the user to easily bend the needle portion in a flat substrate portion for use.

[0020] Furthermore, the present invention aims to provide a stamp-type microneedle that can sterilize and package a substrate portion with needles arranged thereon.

[0021] Furthermore, the present invention aims to provide a stamp-type microneedle that can be used semi-permanently with a user-operated applicator.

[0022] Furthermore, the present invention aims to provide a stamp-type microneedle that can effectively deliver active ingredients or drugs to the user's subcutaneous tissue even when it is not necessary to adhere the substrate portion with the needle portion to the user's skin within a certain time, especially for delivering high volumes of active ingredients or drugs.

[0023] The present invention may include: a pressure section disposed at the upper end of the main body; a medicine cartridge detachably attached to the pressure section; and a base plate disposed between the medicine cartridge and the pressure section, having formed a plurality of needles; the needles formed on the base plate may be bent by means of the pressure transmitted from the pressure section and protrude to the upper part of the medicine cartridge.

[0024] Furthermore, a protruding member may be formed on the upper side of the pressurizing part to pressurize the area where the needle is formed in the overall area of ​​the substrate part, and a connecting protrusion may be formed on the side of the pressurizing part to connect with the drug cartridge.

[0025] Furthermore, the medication cartridge may include: a support, configured to reciprocate linearly on the upper part of the pressure section in a state that can accommodate the base plate portion, and having an opening through which the needle portion or the protruding member can be inserted and passed; an elastic sheet, having a specific curvature, which can elastically contact the upper side of the body when connected to the longitudinal end of the support; and a connecting piece, which is fastened to the connecting protrusion formed on the side of the pressure section when connected to the width end of the support.

[0026] Furthermore, a coupling hole may be formed on the coupling piece for insertion of the coupling protrusion formed on the side of the pressurizing part.

[0027] In addition, the medicine cartridge may also include a handle that protrudes outward in the width direction of the support when connected to the end of the connecting piece.

[0028] In addition, it may include: a cover that is detachably attached to the main body while containing the medicine cartridge and the pressurizing part; and a clamping groove may be formed on the top surface of the cover for inserting and placing the medicine cartridge.

[0029] Furthermore, the clamping groove may include: a first groove into which the support of the drug cartridge is inserted and positioned; and a second groove formed at the location where the first groove is formed to a depth greater than the depth of the first groove; the protruding part of the pressurizing portion may be inserted into the second groove via the opening formed on the support.

[0030] Furthermore, the base plate portion can be inserted and positioned into the inner space of the bracket positioned on the clamp slot.

[0031] Furthermore, the area in which the needle is formed in the region of the base plate portion placed on the support can be inserted into the inner space of the cap and bend under pressure by the pressure portion that is combined with the medicine cartridge.

[0032] Furthermore, when the support of the medicine cartridge comes into contact with the user's skin, as the gap between the support and the upper end of the pressure part decreases, the needle part of the base plate can be inserted into the user's skin through the opening formed on the support.

[0033] According to the stamp-type microneedles of the present invention, consumers can easily bend the flat needle before use, so the substrate can be packaged in a flat shape, thereby simplifying the packaging volume and packaging operation, and multiple substrates can be provided to consumers in a sterilized state.

[0034] Furthermore, the stamp-type microneedle according to the present invention can prevent the pressurizing part, the medicine cartridge, and the substrate part between the two from being contaminated by the outside by means of the cap, and can also perform a clamping action that causes the needle part of the substrate part to bend. Therefore, the consumer only needs to replace the substrate part, while the other components can be used semi-permanently.

[0035] Furthermore, according to the stamp-type microneedle of the present invention, the linear reciprocating movement of the pressure section can be controlled by an elastic sheet integrally connected with the drug cartridge, and since it does not require separate elastic components such as springs, the number of parts can be reduced, thereby saving manufacturing costs.

[0036] Furthermore, the stamp-type microneedles according to the present invention contain bioabsorbable metallic components that provide beneficial effects to the skin when inserted into the skin, thus providing not only skin stimulation and drug delivery effects, but also subcutaneous swelling effects and the function of a drug delivery enhancer.

[0037] Furthermore, the stamp-type microneedles according to the present invention also provide a structure for easily replacing the microneedles inserted into the skin according to the user's needs, thereby preventing infection. Attached Figure Description

[0038] Figure 1 This is a perspective view of a stamp-type microneedle according to one embodiment of the present invention.

[0039] Figure 2 yes Figure 1 The diagram shows a three-dimensional view of the separated stamp-shaped microneedles.

[0040] Figure 3 This is a perspective view of a substrate portion according to one embodiment of the present invention.

[0041] Figure 4 Yes Figure 3 The diagram shows a perspective view illustrating the folded state of the microneedles in the substrate portion.

[0042] Figure 5 This is a perspective view of the main body and the pressurizing part according to one embodiment of the present invention.

[0043] Figure 6 This is a perspective view of a medicine cartridge according to one embodiment of the present invention.

[0044] Figure 7 It is in Figure 5 The diagram shows a three-dimensional view of the main pressurized section containing the pharmaceutical cartridge.

[0045] Figure 8 This is a bottom perspective view illustrating the interior of the lid according to one embodiment of the present invention.

[0046] Figure 9 This is a bottom view of the lid according to one embodiment of the present invention.

[0047] Figure 10 It is in Figure 8 as well as Figure 9 The diagram shows a three-dimensional view of the lid with a medicine cartridge installed in the clamp groove.

[0048] Figure 11 yes Figure 10 The diagram shows the bottom of the lid.

[0049] Figure 12 It is in Figure 10 as well as Figure 11 The inside of the medicine container shown in the diagram contains Figure 3 The bottom view of the substrate portion in the form of a flat plate is shown in the figure.

[0050] Figure 13 To make Figure 12 The diagram shows a cross-sectional view of the base plate where the needle bends and the main body is inserted into the inside of the cover. Detailed Implementation

[0051] The advantages and features of the present invention, as well as the methods for achieving them, will become even clearer through the following detailed embodiments with reference to the accompanying drawings.

[0052] However, the present invention is not limited to the embodiments disclosed below, but can be implemented in many different forms. The embodiments described below are only for the purpose of disclosing the present invention more completely and introducing the scope of the present invention more completely to those skilled in the art to which the present invention pertains. The present invention should only be defined within the scope of the claims.

[0053] Next, please refer to Figures 1 to 13 A detailed description of a stamp-type microneedle according to one embodiment of this disclosure will be provided. In order to prevent obscuring the essence of the invention during the description of the invention, specific descriptions of related well-known functions or configurations will be omitted.

[0054] Figure 1 This is a perspective view of a stamp-type microneedle according to one embodiment of the present invention. Figure 2 yes Figure 1The diagram shows a three-dimensional view of the separated stamp-shaped microneedles. Figure 3 This is a perspective view of the substrate portion according to one embodiment of the present invention. Figure 4 Yes Figure 3 The diagram shows a perspective view illustrating the bent state of the microneedles in the substrate portion. Figure 5 This is a perspective view of the main body and the pressurizing part according to one embodiment of the present invention. Figure 6 This is a perspective view of a medicine cartridge according to one embodiment of the present invention. Figure 7 It is in Figure 5 The diagram shows a three-dimensional view of the main pressurized section containing the reagent cartridge. Figure 8 This is a bottom perspective view illustrating the interior of the lid according to one embodiment of the present invention. Figure 9 This is a bottom view of the lid according to one embodiment of the present invention. Figure 10 It is in Figure 8 as well as Figure 9 The diagram shows a three-dimensional representation of the shape of a medicine cartridge installed in the clamp groove of the lid. Figure 11 yes Figure 10 The diagram shows the bottom surface of the lid. Figure 12 It is in Figure 10 as well as Figure 11 The inside of the medicine container shown in the diagram contains Figure 3 The bottom view of the substrate portion in the form of a flat plate is shown in the figure. Figure 13 To make Figure 12 The diagram shows a cross-sectional view of the base plate where the needle bends and the main body is inserted into the inside of the cover.

[0055] like Figure 1 as well as Figure 2 As shown, a stamp-type microneedle 100 according to an embodiment of the present invention may include: a main body 200; a pressure portion 210 protruding from the upper end of the main body 200; a medicine cartridge 300 detachably attached to the pressure portion 210; a substrate portion 10 disposed between the medicine cartridge 300 and the pressure portion 210, forming a plurality of needle portions 20; and a cap 400 detachably attached to the main body 200 in a state of accommodating the medicine cartridge 300 and the pressure portion 210.

[0056] The main body 200 can refer to the constituent element that is held by the user. Therefore, the main body 200 can have a size and shape that are easy to hold by hand.

[0057] In addition, such as Figure 5As shown, a boss 201 may be formed on the upper peripheral surface of the main body 200. The boss 201 may refer to the part that contacts the lower end of the cover 400, which will be described later, and serves as a limiter to restrict the distance that the main body 200 can move inside the cover 400.

[0058] The pressurizing part 210 can be formed by protruding upward from the upper center of the main body 200 while having a smaller planar area than the planar area formed by the main body 200.

[0059] In addition, such as Figure 5 As shown, a protruding member 211 may be formed on the upper side of the pressurizing portion 210 to pressurize the area in the overall region of the substrate portion 10 where the needle portion 20 is formed. In addition, a connecting protrusion 212 that engages with the drug cartridge 300 may be formed on the side of the pressurizing portion 210.

[0060] The pressure section 210 configured as described above can apply pressure to a portion of the substrate section 10 described later, thereby causing the needle section 20 formed on the substrate section 10 to bend in the vertical direction. At the same time, it can also support the medicine cartridge 300 described later in a manner that allows for linear reciprocating movement, thereby allowing the needle section 20 to be inserted into the user's skin.

[0061] The medicine cartridge 300, as shown Figure 6 as well as Figure 7 As shown, it may include: a support 310, which has a support portion 10 for mounting the substrate (see reference). Figure 3 In a state where it is housed, it is arranged in such a way that it can move linearly back and forth on the upper part of the pressurizing part 200, forming a configuration that allows the needle part 20 (see reference) to be accommodated. Figure 4 The opening 311 through which the protruding member 210 is inserted and passes; the elastic piece 320, which can elastically contact the upper side of the body 200 when connected to the longitudinal end of the bracket 310, and has a specific curvature; and the connecting piece 330, which is fastened to the connecting protrusion 212 formed on the side of the pressure part 200 when connected to the width end of the bracket 310.

[0062] The bracket 310 may have a shape that surrounds the entire outer periphery of the upper end of the pressure portion 210, and may be configured such that when the engagement protrusion 212 of the pressure portion 200 is inserted into the engagement hole 311 formed on the engagement piece 330, it is positioned at a specific distance from the upper side of the pressure portion 210 upward.

[0063] In addition, the bracket 310 can also be inserted into the clamp slot 410 formed on the cover 400 described later (see [reference]). Figure 8It is installed onto the cover 400.

[0064] Furthermore, the opening 311 formed on the support 310 may also have a shape corresponding to the protruding member 211 formed on the upper side of the pressure part 210.

[0065] For reference, in one embodiment of the present invention, the accompanying drawings illustrate an example in which two protruding parts 211 are formed on the upper side of the pressure part 210, and correspondingly, two openings 311 are also formed on the bracket 310.

[0066] The support 310, constructed as described above, can move towards the upper side of the pressure part 210 of the main body 200 by means of the force of the user pressing the pressure part 210 against the skin, and can return to its original state by means of the elastic sheet 320 when the force of the user transmitted to the pressure part 210 is released.

[0067] The elastic sheet 320 can be integrally connected with the bracket 310.

[0068] That is, one end of the elastic sheet 320 along its length can be integrally connected to the end of the bracket 310 along its length. In addition, the other end of the elastic sheet 320 along its length can extend towards the upper side of the main body 200.

[0069] In this way, when a user presses the pressure portion 210 of the main body 200 against the skin, the other end of the elastic sheet 320 in the longitudinal direction can contact the upper side of the main body 200 and undergo elastic bending. Conversely, when the force transmitted to the pressure portion 210 by the user is released, it can return to its original state by means of the elastic recovery force, thereby allowing the support 310 to be spaced upwards from the upper side of the pressure portion 210.

[0070] The connecting piece 330 can also be integrally connected with the bracket 310.

[0071] That is, one end of the connecting piece 330 in the longitudinal direction can be integrally connected to the end of the bracket 310 in the width direction. In addition, the other end of the connecting piece 330 in the longitudinal direction can extend towards the upper side of the main body 200.

[0072] Furthermore, in order to allow the bracket 310 to move, the engagement hole 331 formed on the engagement piece 330 can be formed on the engagement piece 330 in a size that is larger than the size of the engagement protrusion 212 formed on the side of the pressure portion 210.

[0073] That is, in order for the support 310 to move in the direction opposite to the pressure applied when the pressure part 210 applies pressure to the skin, the connecting hole 331 is preferably formed on the connecting piece 330 with a space relatively large compared to the size of the connecting protrusion 212. Therefore, as Figure 7 As shown, even when the connecting protrusion 212 is inserted into and engaged in the connecting hole 331, there is still free space in the connecting hole 331.

[0074] In addition, the medicine cartridge 300 may also include a handle 340, which is held by the user when the support 310 is separated from the pressurizing part 210.

[0075] The handle 340, as Figure 6 as well as Figure 7 As shown, it can be integrally connected with the connecting piece 330. That is, one end of the handle 340 in the longitudinal direction can be integrally connected with the other end of the connecting piece 330 in the longitudinal direction. In addition, the other end of the handle 340 in the longitudinal direction can protrude and extend outward in the width direction of the bracket 310.

[0076] In this way, the user can use the handle 340 to push the connecting piece 330 outward in the width direction of the bracket 310. In this way, the connecting protrusion 212 of the pressure part 210 can be disengaged from the connecting hole 313 of the connecting piece 330.

[0077] The drug cartridge 300 constructed as described above can stably support the substrate portion 10 described later, thereby guiding the needle portion 20 in a planar state to be easily bent in the vertical direction when it is pressed by the protruding member 211 of the pressure portion 210.

[0078] At the same time, when the user presses the pressure part 210 onto the skin, the folded needle part 20 is exposed and inserted into the skin.

[0079] The substrate portion 10 is as follows Figure 3 As shown, it can have a flat plate shape.

[0080] Furthermore, a plurality of needle portions 20 may be patterned in the substrate portion 10.

[0081] The patterned needle portion 20, as shown Figure 3 As shown, it can be configured into a flat panel form.

[0082] In this way, the substrate 10 has a flat shape as a whole, so that it can be packaged in a sterile state and provided to consumers.

[0083] The substrate portion 10, packaged in a flat plate shape, is used after being removed from the packaging paper, such as... Figure 2 as well as Figure 13 As shown, it can be configured between the pressurization section 210 and the support 310 of the medicine cartridge 330.

[0084] The needle portion 20 of the base plate portion 10 disposed between the pressure portion 210 and the support 310 can be bent into the shape of a needle portion 20 by means of the pressure transmitted from the pressure portion 210. Figure 4 As shown, the needles protrude upwards from the upper part of the drug cartridge 300. That is, the plurality of needles 20 formed on the substrate portion 10 can be bent by being pressed by the protruding member 211 formed on the pressure portion 210, and then pass through the opening formed on the support 310 and be exposed to the outside.

[0085] For reference, the substrate portion 10 can be made using a metal containing at least one of magnesium, calcium, zinc, and iron, which are used as bioabsorbable metals. Similarly, the needle portion 20 disposed on the substrate portion 10 can also be made using a metal containing at least one of magnesium, calcium, zinc, and iron, which are used as bioabsorbable metals.

[0086] For reference, there are already cases both domestically and internationally of magnesium-based alloys being manufactured and commercialized for the use of bioabsorbable metals as surgical implants. For bioabsorbable metals suitable for orthopedic implants, the main focus is on minimizing the rate of decomposition in the body or improving corrosion resistance in order to achieve safe fracture fixation.

[0087] However, the bioabsorbable metal forming the substrate portion 10 and the needle portion 20 according to one embodiment of the present invention is different from the bioabsorbable metal suitable for orthopedic use, and can be used to accelerate the decomposition rate in the body while releasing drugs and supplying minerals under the skin.

[0088] For example, magnesium, calcium, and zinc, used as bioabsorbable metals, can have a mechanism that releases hydrogen gas and decomposes by reacting with water in the body. Thus, when the needle portion 20 formed on the substrate portion 10 is inserted into the skin, ions and decomposition products are released subcutaneously, and one of the byproducts, hydrogen gas, provides a plumping effect under the skin, thereby improving wrinkles.

[0089] Simultaneously, the byproducts ZnO and MgCl generated when the components of the bioabsorbable metal, namely magnesium and zinc, are inserted into the body can remain subcutaneously, thereby acting as a drug delivery enhancer to improve the subcutaneous absorption of active ingredients or drugs. Therefore, the substrate portion 10 and needle portion 20 formed using the bioabsorbable metal also have the function of effectively delivering the active ingredients or drugs they carry, or those delivered from the outside, to the subcutaneous layer.

[0090] For reference, stainless steel, used as microneedles, has higher strength, elastic modulus, and melting point compared to magnesium. Therefore, machining the needles into a flat surface results in more tool wear and energy consumption, ultimately increasing manufacturing costs. Even with non-contact methods like laser processing, the higher melting point of magnesium requires more energy and generates more heat, creating burrs on the processed surface, necessitating burr removal and incurring costs. In contrast, magnesium alloys have a tensile strength of approximately 100–400 MPa, sufficient to penetrate skin, and an elastic modulus of approximately 40–60 GPa, requiring significantly less force to bend than stainless steel. Magnesium's melting point is approximately 650–750°C, allowing for processing with relatively less energy, and producing a cleaner surface compared to stainless steel, thus eliminating the need for post-processing. Furthermore, in cases where a needle inserted into the skin breaks off or leaves residue, stainless steel may cause inflammation or migration within the skin, potentially leading to conditions such as pain and necrosis, while magnesium alloys have the advantage of being able to decompose and dissolve safely.

[0091] The cover 400 Figure 1 as well as Figure 2 As shown, it can be detachably attached to the upper part of the main body 200.

[0092] In addition, the lid 400, as Figure 8 as well as Figure 9 As shown, a space is formed on the inside to accommodate the pressurization part 210 and the medicine cartridge 300.

[0093] A clamping groove 410 can be formed on the top surface of the cap 400 for inserting and placing the medicine cartridge 300.

[0094] The clamp slot 410 may include: a first slot 420 into which the support 310 of the medicine cartridge 300 is inserted and placed; and a second slot 430 formed at the location where the first slot 420 is formed, at a depth greater than the depth of the first slot 420.

[0095] The first groove 410 may have a shape corresponding to the support 310 of the medicine cartridge 300.

[0096] The second groove 430 may have a shape corresponding to the protruding part 211 of the pressure part 210.

[0097] In this way, such as Figure 10 as well as Figure 11As shown, the user can place the medicine cartridge 300 into the clamp slot 410 by inserting it into the inner space of the cap 400.

[0098] like Figure 10 as well as Figure 11 As shown, the reason for inserting and fixing the medicine cartridge 300 into the inner space of the cap 400 is to apply pressure to the needle portion 20 formed on the substrate portion 10 after providing space for the flat substrate portion 10 to be placed, so that the needle portion 20 is bent.

[0099] That is, the substrate portion 10 is as follows Figure 12 As shown, it can be inserted and placed into the inner space of the bracket 310 placed on the clamp slot 410.

[0100] The area in which the needle portion 20 is formed in the region of the substrate portion 10 disposed on the support 310 is as follows: Figure 13 As shown, the pressurizing part 210, which can be inserted into the inner space of the cap 400 and combined with the medicine cartridge 300, can be pressurized and bent.

[0101] Specifically, such as Figure 13 As shown, the pressure part 210 can be inserted into the inner space of the flipped cover 400 in the direction of arrow A, thereby pressurizing the needle part 20 of the base plate part 10 placed on the support 310. That is, the protruding part 211 of the pressure part 210 can be inserted into the second groove 430 of the clamp groove 410 after pressurizing the needle part 20 placed on the support 310.

[0102] At this time, the needle portion 20 of the substrate portion 10, which is in the form of a flat plate, can be bent in the vertical direction by means of the protruding member 211. At the same time, the connecting protrusion 212 formed on the side of the pressure portion 210 can be inserted into the connecting hole 331 formed on the connecting piece 330 of the medicine cartridge 300.

[0103] In the state described above, when the force transmitted to the pressurizing part 210 is released, the main body 200 and the pressurizing part 210 can move towards the elastic sheet 320 of the medicine cartridge 300 by means of the elastic sheet 320. Figure 13 Move in the direction of arrow B shown in the diagram.

[0104] In the state described above, the needle portion 20 disposed between the pressure portion 210 and the bracket 310 is as follows: Figure 4 As shown, it can be deformed into a shape that can be inserted into the skin.

[0105] The user can detach the cap 400 from the main body 200 to insert the needle 20 into the skin. Next, when the main body 200 is pressed against the skin with the support 310 of the medicine cartridge 300 in contact with the skin, the gap between the upper end of the pressure section 210 and the support 310 decreases. At this time, the base plate 10 is pressurized by the pressure section 210 and moves towards the skin, allowing the folded needle 20 to pass through the opening 311 formed on the support 310 and be inserted into the skin.

[0106] For reference, the inner circumferential surface of the cover 400 can be formed as shown in the figure. Figure 13 The edge groove 401, and the protrusion 202 formed on the upper peripheral surface of the main body 200 (see...) Figure 5 It can be inserted into the edge groove 401.

[0107] The stamp-type microneedle 100 with the configuration described above allows consumers to easily bend the flat needle portion 20 before use, thus enabling the substrate portion 10 to be packaged in a flat shape, thereby simplifying the packaging volume and packaging operation. At the same time, multiple substrate portions 10 can be provided to consumers in a sterilized state.

[0108] Furthermore, the stamp-type microneedle 100 according to the present invention can prevent the pressure part 210 and the medicine cartridge 300 and the substrate part 10 between them from being contaminated by the outside by means of the cap 400, and can also perform a clamping action that causes the needle part 20 of the substrate part 10 to bend. Therefore, the consumer only needs to replace the substrate part 10, while the other components can be used semi-permanently.

[0109] Furthermore, according to the stamp-type microneedle 100 of the present invention, the linear reciprocating movement of the pressure section 210 can be controlled by the elastic sheet 320 integrally connected with the medicine cartridge 300, and since it does not require separate elastic components such as springs, the number of parts can be reduced, thereby saving manufacturing costs.

[0110] Furthermore, although many people have a fear of needles, the stamp-type microneedles according to one embodiment of the present invention can eliminate the fear by concealing the needle part 20, and after contact with the skin, the user can appropriately control the force while feeling pain, thereby using them properly.

[0111] Furthermore, to prevent breakage when the needle 20 penetrates the skin, a partition wall dividing the opening 311 of the drug cartridge 300 supports the needle 20. Thus, when used with the active ingredient, pressure can be applied by the protruding part after penetration by the needle 20, thereby pressurizing the active ingredient present between the needles and significantly improving skin absorption.

[0112] In the foregoing, specific embodiments of the present invention have been described, but various modifications can be made without departing from the scope of the present invention.

[0113] Therefore, the scope of the present invention is not limited to the illustrated embodiments, but should be defined within the scope of the appended claims and the scope of the claims themselves.

[0114] Industry availability This invention can be sold and used in various industries, such as the medical field and the skin care field.

Claims

1. A stamp-type microneedle, characterized by, Comprising: a pressing portion provided at an upper end of the main body; a medicine cartridge coupled to the pressing portion in a detachable manner; and a substrate portion disposed between the medicine cartridge and the pressing portion, formed with a plurality of needle portions; The needle portions formed on the substrate portion are bent by the pressure transmitted from the pressing portion and protrude toward the upper portion of the medicine cartridge.

2. The stamp-type microneedle according to claim 1, wherein a protruding member that presses a region in which the needle portions are formed in the entire region of the substrate portion is formed on the upper side of the pressing portion, a coupling protrusion that is coupled to the medicine cartridge is formed on the side of the pressing portion.

3. The stamp-type microneedle according to claim 2, wherein the medicine cartridge comprises: a holder disposed in a state in which it can accommodate the substrate portion in a linear reciprocating manner on the upper portion of the pressing portion, formed with an opening portion through which the needle portions or the protruding member can be inserted and passed, a resilient sheet that can be in elastic contact with the upper side of the main body in a state in which it is connected to the lengthwise end of the holder, having a specific curvature, and a coupling sheet that is fastened to the coupling protrusion formed on the side of the pressing portion in a state in which it is connected to the widthwise end of the holder.

4. The stamp-type microneedle according to claim 3, wherein a coupling hole into which the coupling protrusion formed on the side of the pressing portion is inserted is formed on the coupling sheet.

5. The stamp-type microneedle according to claim 3, wherein the medicine cartridge further comprises: a handle that protrudes outward in the widthwise direction of the holder in a state in which it is connected to the end of the coupling sheet.

6. The stamp-type microneedle of claim 3, wherein, Comprising: a lid that is coupled to the main body in a detachable manner in a state in which it accommodates the medicine cartridge and the pressing portion; a clamp groove in which the medicine cartridge is inserted and seated is formed on the top surface of the lid.

7. The stamp-type microneedle according to claim 6, wherein the clamp groove comprises: a first groove into which the holder of the medicine cartridge is inserted and seated, and a second groove formed at a depth deeper than that of the first groove at a position at which the first groove is formed; the protruding member of the pressing portion is inserted into the second groove via the opening portion formed on the holder.

8. The stamp-type microneedle according to claim 7, wherein the substrate portion is inserted and seated into the inner space of the holder seated on the clamp groove.

9. The stamp-type microneedle according to claim 8, wherein the region in which the needle portions are formed in the region of the substrate portion seated on the holder is bent by the pressing of the pressing portion inserted into the inner space of the lid and coupled to the medicine cartridge.

10. The stamp-type microneedle according to claim 3, wherein when the holder of the medicine cartridge comes into contact with the skin of a user, the needle portions of the substrate portion are inserted into the skin of the user through the opening portion formed on the holder while the interval between the holder and the upper end of the pressing portion decreases.

Images