High-strength deformable porous hydrogel for postoperative abdominal cavity tissue effusion drainage

The porous hydrogel prepared by freeze polymerization and salting-out effect, combined with temperature-sensitive structure and electrothermal control, solves the problems of low drainage efficiency and fixed position of postoperative drainage materials, and achieves high-strength and deformable drainage effect, reducing the risk of postoperative complications.

CN121537673AActive Publication Date: 2026-02-17ZHEJIANG CANCER HOSPITAL
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Patent Information

Application Number
CN202610085320.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-22
Publication Date
2026-02-17
Estimated Expiration
2046-01-22

AI Technical Summary

Technical Problem

Existing postoperative drainage materials suffer from low drainage efficiency, easy blockage, and inability to dynamically adjust the drainage position, making it difficult to achieve efficient and precise drainage, especially in cases of peritoneal fluid accumulation caused by organ fistula.

Method used

Porous hydrogels were prepared using a freeze polymerization process, and their mechanical properties were improved by combining the salting-out effect. The drainage position was adjusted in real time through a temperature-sensitive structure design, and dynamic drainage was achieved by using electrothermal control.

Benefits of technology

It achieves efficient and stable drainage of peritoneal fluid, reduces the incidence of complications, and has the ability to adjust the drainage position in real time.

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Abstract

The invention discloses high-strength deformable porous hydrogel for postoperative abdominal cavity tissue effusion drainage, belongs to the technical field of medical porous hydrogel, and particularly relates to a temperature-sensitive hydrogel reaction solution obtained by adding a monomer, a cross-linking agent and an initiator into water and mixing, and freezing and polymerizing to obtain ice gel; treating the ice gel in a salting-out solution to obtain porous hydrogel; the cross-linking agent is prepared from at least one of N, N-methylene bisacrylamide, N, N-methylene bisacrylamide and polyethylene glycol diacrylate. The invention provides the high-strength deformable porous hydrogel for postoperative abdominal cavity tissue effusion drainage, which has a temperature-sensitive effect, can be dynamically controlled through electric heating, and has good mechanical properties and a good drainage effect.
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