Essential oil for relieving cardiovascular and cerebrovascular diseases and preparation method thereof

Abstract

The invention relates to the technical field of plant essential oil, in particular to essential oil for relieving cardiovascular and cerebrovascular diseases and a preparation method of the essential oil. 15-25 parts of a traditional Chinese medicine preparation powder raw material; 20 to 35 parts of a glue solution; wherein the raw materials of the plant essential oil comprise lavender, onion, peanut and garlic, the raw materials of the traditional Chinese medicine preparation powder comprise uncaria and radix achyranthis bidentatae, and the glue solution comprises medicinal gelatin, glycerin, sorbitol, hydroxypropyl methyl cellulose, propylene glycol, citric acid and pure water. Through scientific proportioning of the plant essential oil and the traditional Chinese medicine powder, specific process extraction and glue solution coating targeted controlled release, multi-target adjustment of cardiovascular and cerebrovascular indexes is realized, bioavailability and stability are improved, and safety is guaranteed. Therefore, the problems of large side effect, poor targeting property, easy loss of effective components, low bioavailability, single curative effect and the like of the traditional cardiovascular and cerebrovascular relieving product are solved.

Description

Technical Field

[0001] This invention relates to the field of plant essential oil technology, specifically to an essential oil for relieving cardiovascular and cerebrovascular diseases and its preparation method. Background Technology

[0002] Cardiovascular and cerebrovascular diseases mainly refer to diseases of the cardiovascular and cerebrovascular systems. They are circulatory system diseases that have serious effects on both local and systemic aspects. These diseases are caused by factors such as high blood pressure, smoking, alcohol consumption, high blood sugar, abnormal blood lipids, and metabolic disorders, leading to ischemic or hemorrhagic lesions in the brain, heart, and other tissues throughout the body. Cardiovascular and cerebrovascular diseases have become a serious threat to human life and health. Common cardiovascular and cerebrovascular diseases in modern populations include cerebrovascular diseases, coronary heart disease, myocardial infarction, rheumatic heart disease, and pulmonary heart disease.

[0003] Cardiovascular and cerebrovascular diseases are often triggered by hypertension, hyperlipidemia, and hyperglycemia (the "three highs"). Patients with these conditions should be cautious with medication, as every drug has certain side effects and may cause varying degrees of irritation to blood vessels and other organs. Western medicines, in particular, have a higher potential for side effects, such as gastric erosion (aspirin) and agranulocytosis (ticlopidine). Compared to Western medicines, traditional Chinese medicine has far fewer side effects. Therefore, developing an essential oil with fewer side effects to alleviate cardiovascular and cerebrovascular diseases is essential.

[0004] Furthermore, existing preparation processes have several shortcomings: plant essential oil extraction often employs high-temperature distillation, which easily leads to the oxidative degradation of heat-sensitive active ingredients; during the preparation of traditional Chinese medicine powders, high-temperature drying can easily cause the inactivation of active ingredients; and the lack of an effective controlled-release system results in large fluctuations in the blood concentration of active ingredients, affecting both efficacy and increasing safety risks. Therefore, developing an essential oil product that is synergistic in its components, highly targeted, stable, bioavailable, and safe and gentle for alleviating cardiovascular and cerebrovascular diseases has become an urgent need in the field of cardiovascular and cerebrovascular health. Summary of the Invention

[0005] This application provides an essential oil for relieving cardiovascular and cerebrovascular diseases and its preparation method, in order to solve the problems of traditional cardiovascular and cerebrovascular relief products, such as large side effects, poor targeting, easy loss of effective ingredients, low bioavailability, and single therapeutic effect.

[0006] This application provides an essential oil for alleviating cardiovascular and cerebrovascular diseases, the essential oil comprising the following weight proportions: Plant essential oil ingredients: 40-60 parts; Traditional Chinese medicine powder raw materials: 15-25 parts; Adhesive solution: 20-35 parts; The plant essential oil raw materials are composed of lavender, onion, peanut, and garlic; the traditional Chinese medicine preparation powder raw materials are composed of Uncaria rhynchophylla and Achyranthes bidentata; and the adhesive liquid is composed of pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid, and purified water.

[0007] Optionally, the plant essential oil raw material comprises the following parts by weight: Lavender: 10-15 parts; Onions: 10-15 servings; Peanuts: 10-15 servings; Garlic: 10-15 servings.

[0008] Optionally, the raw materials for the traditional Chinese medicine preparation powder include the following parts by weight: Uncaria rhynchophylla: 8-12 parts; Achyranthes bidentata: 7-13 parts.

[0009] Optionally, the adhesive comprises the following parts by weight: Pharmaceutical grade gelatin: 8-10 parts; Glycerin: 1-3 parts; Sorbitol: 2-4 parts; Hydroxypropyl methylcellulose: 1-3 parts; Propylene glycol: 1-2 parts; Citric acid: 0.05-0.1 parts; Pure water: 2-3 parts.

[0010] Optionally, the preparation method of the plant essential oil raw material is as follows: Mince the garlic into small pieces less than 3mm in diameter and let it stand at 10-20℃ for 8-12 minutes. Lavender, onion, and peanut are mixed evenly in a weight ratio, and then pulverized at -10 to 5℃ until the particle size is less than 9mm, and then ground until the particle size is less than 0.1mm to obtain frozen plant powder. Mix minced garlic and frozen plant powder evenly according to the weight ratio, thaw at 20-30℃ for 40-50 minutes, add 8-10 times the weight of the minced garlic in dichloromethane, and extract ultrasonically at 20-30℃ and 30-40kHz for 40-50 minutes. Filter to obtain filtrate and residue. Repeat the extraction of residue 3-5 times, combine the filtrates, and let stand at 30-40℃ and 1-2kPa for 10-12 hours to obtain plant essential oil.

[0011] Optionally, the preparation method of the traditional Chinese medicine preparation powder raw material is as follows: Mix Uncaria rhynchophylla and Achyranthes bidentata evenly according to the weight ratio, and grind them at -10-5℃ until the particle size is less than 1mm. Place the ground mixture in pure water at 20-25 times its weight of Uncaria rhynchophylla, bring to a boil over high heat, then simmer over low heat for 3-4 hours, and filter to remove impurities. The filtrate was allowed to stand at 30-40℃ and 50-100Pa until all the water evaporated, thus obtaining the powder of the traditional Chinese medicine preparation.

[0012] Optionally, the preparation method of the adhesive solution is as follows: Mix pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid and pure water in a uniform weight ratio, and stir for 80-100 minutes at 60-70℃ and 2000-2500r / min. After cooling to 10-20℃, vacuum is applied for 4-6 hours under -0.06-0.08MPa conditions, and the solution is passed through a 100-120 mesh sieve to obtain the adhesive solution.

[0013] This application also proposes a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, comprising the following steps: Step 1: Prepare plant essential oils, traditional Chinese medicine powders, and liquids according to the specified weight ratios, and set aside for later use; Step 2: Mix the Chinese herbal medicine powder and plant essential oil evenly according to the weight ratio to prepare Chinese herbal plant essential oil; Step 3: The herbal plant essential oils are encapsulated in a gelatinous solution using a pelleting machine. The pelleting process parameters are: weight 0.8-1g / pellet, temperature 20-24℃, relative humidity 40-50%. Step 4: Place the sac-pressed product in a nitrogen atmosphere at 1-10℃ for 1-2 hours to set, and wash it with 95% edible alcohol 3-5 times. Step 5: Dry at 24-30℃ and 30-40% relative humidity for 15-20 hours to obtain the finished essential oil.

[0014] Optionally, in step two, the mixing process uses a stirring rate of 120-150 r / min and a stirring time of 20-30 min to ensure uniform mixing.

[0015] This application also proposes an application of an essential oil for relieving cardiovascular and cerebrovascular diseases, specifically for alleviating symptoms of cardiovascular and cerebrovascular circulatory disorders such as hypertension, hyperlipidemia, hyperglycemia, and coronary heart disease.

[0016] Therefore, this application has at least the following beneficial effects: (1) In the embodiments of this application, garlic is activated by standing at 10-20℃ to convert allicin into allicin, which can specifically inhibit the activity of angiotensin-converting enzyme (ACE), block the vasoconstriction pathway, and inhibit platelet aggregation at the same time; linalool of lavender essential oil promotes vasodilation by regulating potassium ion channels in vascular smooth muscle; prostaglandin A of onion dilates peripheral blood vessels and reduces blood viscosity; unsaturated fatty acids of peanut regulate lipid metabolism and reduce the deposition of atherosclerotic plaques; in the powder of traditional Chinese medicine preparation, rhizomorphine of Uncaria rhynchophylla selectively blocks L-type calcium ion channels in vascular smooth muscle, inhibits calcium ion influx and reduces peripheral vascular resistance, while improving myocardial oxygen consumption; polysaccharides and oleanolic acid of Achyranthes bidentata improve blood rheology, inhibit platelet aggregation and regulate the activity of liver lipid metabolism enzymes. The cavitation effect of ultrasonic extraction and the low-temperature environment ensure the high activity of plant essential oils, while the low-temperature grinding and vacuum drying of traditional Chinese medicine preserve the activity of water-soluble active ingredients. The two form a lipid-soluble-water-soluble synergistic system, which can not only quickly dilate blood vessels and lower blood pressure, but also regulate blood lipid metabolism and improve blood rheology in the long term, effectively relieving various cardiovascular and cerebrovascular circulatory disorders. (2) In the embodiments of this application, the pharmaceutical gelatin forms a three-dimensional network structure at 60-70℃, providing a stable carrier for the active ingredients; glycerol and sorbitol improve the flexibility of the film, hydroxypropyl methylcellulose acts as a hydrophilic gel skeleton to regulate the swelling rate, propylene glycol promotes the dissolution and diffusion of the active ingredients, and citric acid stabilizes the chemical structure of the ingredients. After oral administration, the film slowly swells in the gastric juice (28.5%-32.1% release rate in 2 hours), avoiding the destruction of the active ingredients by gastric acid and digestive enzymes; after entering the intestinal juice, it gradually dissolves, and the active ingredients are continuously released through diffusion via the gel skeleton. The cumulative release rate in 12 hours reaches 89.2%-93.6%, and the cumulative release rate in 24 hours is ≥98.5%. The blood drug concentration is stable without peaks and valleys, which reduces the risk of adverse reactions and significantly improves bioavailability. (3) In the embodiments of this application, the dense coating layer formed by the adhesive can effectively block oxygen, moisture and light, avoid the oxidative loss of volatile components such as allicin and linalool in plant essential oils, and the degradation and inactivation of effective components of traditional Chinese medicine (uncariae and achyranthes polysaccharide); at the same time, the extraction of plant essential oils adopts a low temperature ultrasonic process of 20-30℃, and the traditional Chinese medicine powder adopts vacuum drying of 30-40℃, both of which avoid the inactivation of components caused by high temperature. After 12 months of storage at room temperature (25℃) and under sealed conditions, the average retention rate of effective components (allicin, uncariae and oleanolic acid) reached 91.8%-93.8%, which is far superior to the uncoated essential oil products (retention rate of only 65% ​​after 6 months of storage) and traditional Chinese medicine pills (retention rate of 83.0% after 12 months of storage), and the appearance and hardness of the product did not change significantly, and the stability was significantly improved. (4) The raw materials in the embodiments of this application are all natural plants or pharmaceutical excipients. The plant essential oils and traditional Chinese medicine preparations are all derived from food and medicine or traditional Chinese medicine. The safety has been verified over a long period of time. The controlled release effect of the gel avoids the rapid release of effective ingredients, which leads to excessively high blood drug concentration and reduces the risk of gastrointestinal irritation. No chemically synthesized preservatives or stabilizers are added during the preparation process, and the product has high purity. No toxic reactions were observed in the acute toxicity test (5g / kg for mice by gavage). In the long-term toxicity test (1g / kg·d for rats by gavage, for 90 consecutive days), there were no significant abnormalities in blood routine, liver and kidney function, and organ coefficients. No side effects such as liver and kidney damage or gastrointestinal irritation were observed. The safety is better than that of traditional Chinese medicine pills (15% incidence of mild diarrhea), and it is suitable for long-term intervention for patients with cardiovascular and cerebrovascular diseases. (5) In the embodiments of this application, the extraction of plant essential oils uses the 30-40kHz ultrasonic cavitation effect, which efficiently destroys the plant cell structure. Dichloromethane, as a fat-soluble solvent, can be recycled (recovery rate ≥90%), avoiding solvent waste and environmental pollution. In the preparation of traditional Chinese medicine powder, the residue can be recycled as organic fertilizer raw material, with no solid waste discharge and an industrial solid waste utilization rate ≥90%. The pill-making process has a high degree of automation, simple operation, and high production efficiency, making it suitable for large-scale production. The entire preparation process does not require high-energy-consuming steps such as high-temperature calcination, which is in line with the concept of green production.

[0017] This solves the problems of traditional cardiovascular and cerebrovascular relief products, such as large side effects, poor targeting, easy loss of effective ingredients, low bioavailability, and single therapeutic effect.

[0018] Additional aspects and advantages of this application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of this application. Attached Figure Description

[0019] The above and / or additional aspects and advantages of this application will become apparent and readily understood from the following description of the embodiments taken in conjunction with the accompanying drawings, wherein: Figure 1 This is a flowchart illustrating a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, according to an embodiment of this application. Detailed Implementation

[0020] The technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort are within the scope of protection of this application.

[0021] In the embodiments of this application, unless otherwise specified, the raw materials or processing techniques are conventional commercially available raw materials or conventional processing techniques in the art.

[0022] The present application will now be described with reference to specific embodiments. It should be noted that these embodiments are merely descriptive and do not limit the present application in any way. Example 1

[0023] This application provides an essential oil for alleviating cardiovascular and cerebrovascular diseases. The essential oil comprises the following parts by weight: Plant essential oil ingredients: 40 parts; Traditional Chinese medicine powder raw materials: 15 parts; Adhesive liquid: 20 parts; The plant essential oil raw materials are composed of lavender, onion, peanut, and garlic; the traditional Chinese medicine preparation powder raw materials are composed of Uncaria rhynchophylla and Achyranthes bidentata; and the adhesive liquid is composed of pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid, and purified water.

[0024] The plant essential oil raw materials include the following weight proportions: Lavender: 10 servings; Onions: 10 servings; Peanuts: 10 servings; Garlic: 10 servings.

[0025] The raw materials for the powder of traditional Chinese medicine preparations include the following weight proportions: Uncaria rhynchophylla: 8 parts; Achyranthes bidentata: 7 parts.

[0026] The adhesive solution comprises the following parts by weight: Pharmaceutical gelatin: 8 parts; Glycerin: 1 part; Sorbitol: 2 parts; Hydroxypropyl methylcellulose: 1 part; Propylene glycol: 1 part; Citric acid: 0.05 parts; Pure water: 2 parts.

[0027] The preparation method for plant essential oils is as follows: Mince the garlic into small pieces less than 3mm in diameter and let it stand at 10℃ for 12 minutes. Lavender, onion, and peanut are mixed evenly in a weight ratio, and then crushed at -10℃ until the particle size is less than 9mm, and then ground until the particle size is less than 0.1mm to obtain frozen plant powder. Garlic paste and frozen plant powder were mixed evenly according to the weight ratio, thawed at 20℃ for 50 minutes, and then 8 times the weight of dichloromethane was added. The mixture was ultrasonically extracted at 20℃ and 30kHz for 50 minutes. The mixture was filtered to obtain filtrate and residue. The residue was extracted three times. The filtrates were combined and allowed to stand at 30℃ and 1kPa for 12 hours to obtain plant essential oil.

[0028] The preparation method of traditional Chinese medicine powder is as follows: Mix Uncaria rhynchophylla and Achyranthes bidentata evenly according to the weight ratio, and grind them at -10℃ until the particle size is less than 1mm. Place the ground mixture in pure water at 20 times its weight of Uncaria rhynchophylla, bring to a boil over high heat, then simmer over low heat for 3 hours, and filter to remove impurities. The filtrate was allowed to stand at 30℃ and 50Pa until all the water evaporated, thus obtaining the powder of the traditional Chinese medicine preparation.

[0029] The preparation method of the adhesive solution is as follows: Mix pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid and pure water in a uniform weight ratio and stir for 100 min at 60℃ and 2000 r / min. After cooling to 10℃, the solution was vacuumed for 6 hours under -0.06MPa conditions and passed through a 100-mesh sieve to obtain the adhesive solution.

[0030] This application also proposes a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, comprising the following steps: Step 1: Prepare plant essential oils, traditional Chinese medicine powders, and liquids according to the specified weight ratios, and set aside for later use; It is understood that in the embodiments of this application, plant essential oils, traditional Chinese medicine powders, and adhesives are prepared separately according to weight ratios and kept for later use. This ensures that the purity and activity of each raw material are not subject to cross-interference, avoids the loss due to volatilization of plant essential oils, the hygroscopic clumping of traditional Chinese medicine powders, or the impact on the stability of the adhesive system. At the same time, by precisely controlling the basic amount of each raw material through precise proportioning, a precise material foundation is laid for the subsequent mixing and encapsulation process according to specific ratios. This ensures that each core functional component (the active factors of essential oils, the efficacy components of traditional Chinese medicine powders, and the film-forming carrier of adhesives) retains its original performance completely, effectively avoids the damage to the characteristics of different materials caused by mixing and preparation, and ensures the stability of the core efficacy of the finished essential oil.

[0031] Step 2: Mix the Chinese herbal medicine powder and plant essential oil evenly according to the weight ratio. The mixing process is carried out at a stirring speed of 120r / min and a stirring time of 30min to prepare the Chinese herbal plant essential oil. It is understood that in the embodiments of this application, the traditional Chinese medicine powder and plant essential oil are mixed by weight ratio, and a stirring rate of 120 r / min and a stirring time of 30 min are used. This not only allows the effective components of the traditional Chinese medicine powder and the active factors of the plant essential oil to form a synergistic system through precise proportions, maximizing the combined efficacy of the two, but also ensures uniform mixing with appropriate stirring parameters, avoiding efficacy deviations caused by local component concentration imbalances. At the same time, gentle stirring can reduce the volatilization of plant essential oils and the destruction of effective components of traditional Chinese medicine, so that the mixed system forms a stable traditional Chinese medicine and plant essential oil matrix, providing a uniform and stable core material for the subsequent glue encapsulation process, ensuring the consistency of composition and efficacy stability of each finished product.

[0032] Step 3: The herbal plant essential oils are encapsulated in a gelatinous liquid using a pelleting machine. The pelleting process parameters are: 0.8g / pellet, temperature 20℃, and relative humidity 40%. It is understood that in this embodiment, the herbal plant essential oils are encapsulated in a gelatinous liquid using a pelleting machine. The encapsulation effect of the gelatinous liquid forms a physical protective barrier, preventing the essential oils from evaporating and being lost, and preventing the effective components of the herbal medicine from deteriorating due to external environmental factors (oxygen, humidity). Precise control of the dosage of 0.8g / pill ensures that the content of the effective components in each finished product is uniform, guaranteeing the accuracy of the dosage. The temperature of 20°C and the relative humidity of 40% provide a suitable environment for the gelatinous liquid to form a film, avoiding excessively high temperatures that cause the essential oils to evaporate, excessively low temperatures that affect the fluidity of the gelatinous liquid, excessive humidity that causes the pellets to stick together, and excessively small pellets that result in loose encapsulation. At the same time, the pelleting process makes the product into a regular shape, which is not only convenient for subsequent shaping, washing and drying operations, but also improves the quantitative convenience during use, laying the foundation for the standardized production of the finished product.

[0033] Step 4: Place the sac-pressed product in a nitrogen atmosphere at 1°C for 2 hours to set, and wash it 3 times with 95% edible alcohol. It is understood that in this embodiment, the pills are set for 2 hours in a nitrogen atmosphere at 1°C. The nitrogen atmosphere can isolate oxygen and prevent the oxidation and deterioration of the herbal plant essential oils. The low temperature environment can maintain the stability of the film and the activity of the core components, while promoting the solidification of the pill form and preventing deformation and damage during subsequent washing. Washing with 95% edible alcohol three times can effectively remove uncoated raw materials and impurities remaining on the surface of the pills, improve the purity of the product, and edible alcohol is highly safe and volatile, so it will not leave residue on the product surface, avoiding any impact on the safety of the finished product. At the same time, the clean surface of the washed pills provides a uniform and clean material state for the subsequent drying process, ensuring the uniformity of the appearance and internal quality of the finished product.

[0034] Step 5: Dry at 24℃ and 30% relative humidity for 20 hours to obtain the finished essential oil.

[0035] It is understood that in this embodiment, drying at 24℃ and 30% relative humidity for 20 hours provides a gentle drying environment that avoids high temperatures damaging the active factors of plant essential oils and the effective components of traditional Chinese medicine preparations, ensuring that the core efficacy of the finished product is not lost. Through 20 hours of continuous drying and humidity control, the moisture content of the pills can be made up to standard, inhibiting the growth of mold and bacteria, preventing the finished product from absorbing moisture and becoming moldy during storage and transportation, and extending the product's shelf life. At the same time, the dried finished pills are stable in shape, not easy to stick together and clump, making them easy to package, handle and use. The uniform moisture content ensures the storage stability and efficacy consistency of each product, avoiding quality fluctuations caused by differences in moisture content, and ultimately ensuring the comprehensive performance and use effect of the finished essential oil.

[0036] This application also proposes an application of an essential oil for relieving cardiovascular and cerebrovascular diseases, specifically for alleviating symptoms of cardiovascular and cerebrovascular circulatory disorders such as hypertension, hyperlipidemia, hyperglycemia, and coronary heart disease.

[0037] For example, in routine health care or as directed by a doctor, an essential oil used to alleviate cardiovascular and cerebrovascular diseases can be taken orally at an appropriate dose (e.g., one capsule twice daily). This essential oil is prepared from plant essential oil raw materials, traditional Chinese medicine powder raw materials, and colloids through precise proportions and specific processes. The plant essential oil raw materials are carefully selected from lavender, onion, peanut, and garlic in a specific weight ratio. The process of "garlic low-temperature static activating allicin + low-temperature pulverization of mixed raw materials - ultrasonic extraction - vacuum concentration" maximizes the retention of the activity of terpenes, phenols, allicin, prostaglandin A, etc. The ingredients can help dilate blood vessels, improve microcirculation, and inhibit platelet aggregation. The powder raw material of the traditional Chinese medicine preparation is made by combining Uncaria rhynchophylla and Achyranthes bidentata in a certain weight ratio, and is prepared by low-temperature pulverization, water decoction and vacuum drying. It is enriched with components such as Uncaria rhynchophylla alkaloid and Achyranthes bidentata polysaccharide, and has the effects of promoting blood circulation and removing blood stasis, calming the liver and lowering blood pressure, and clearing the meridians. It can specifically improve vascular endothelial function and reduce blood viscosity. The gel is made with pharmaceutical gelatin as the base material, compounded with glycerin, sorbitol and other excipients, and is prepared by high-temperature stirring, vacuum degassing and sieving. It has good film-forming properties and good biocompatibility, and can achieve stable encapsulation of the core active ingredients. The powdered traditional Chinese medicine preparation and plant essential oils are mixed by weight ratio and stirred evenly at 120-150 rpm for 20-30 minutes to ensure that the two types of active ingredients are fully integrated and synergistically enhanced, avoiding efficacy deviations caused by component separation. The mixture is then pressed into regular pills of 0.8-1g / pill using a pelleting machine at 20-24℃ and 40-50% relative humidity. The gel coating layer protects the active ingredients from damage by the gastrointestinal environment and enables targeted release into the intestines. Subsequently, the mixture is set in a nitrogen atmosphere at 1-10℃ for 1-2 hours to isolate oxygen and prevent oxidation and deterioration. Washing with 95% edible alcohol 3-5 times removes surface impurities and improves product purity. Finally, drying at 24-30℃ and 30-40% relative humidity for 15-20 hours ensures that the active ingredients are not lost, controls product moisture, inhibits bacterial growth, and extends shelf life. This essential oil, through the synergistic effect of plant essential oils and traditional Chinese medicine ingredients, combined with precise preparation technology, can effectively alleviate symptoms of cardiovascular and cerebrovascular disorders such as chest tightness, dizziness, and limb numbness caused by hypertension, hyperlipidemia, hyperglycemia, and coronary heart disease (e.g., systolic blood pressure drops from 160 / 100 mmHg to below 130 / 85 mmHg, and total cholesterol and triglyceride levels return to the normal reference range). At the same time, relying on stable dosage form design and process control, it ensures the consistency of product efficacy and safety of use, providing continuous protection for cardiovascular and cerebrovascular health. Example 2

[0038] This application provides an essential oil for alleviating cardiovascular and cerebrovascular diseases. The essential oil comprises the following parts by weight: Plant essential oil ingredients: 45 parts; Traditional Chinese medicine powder raw materials: 17.5 parts; Adhesive solution: 23.75 parts; The plant essential oil raw materials are composed of lavender, onion, peanut, and garlic; the traditional Chinese medicine preparation powder raw materials are composed of Uncaria rhynchophylla and Achyranthes bidentata; and the adhesive liquid is composed of pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid, and purified water.

[0039] The plant essential oil raw materials include the following weight proportions: Lavender: 11.25 servings; Onions: 11.25 servings; Peanuts: 11.25 servings; Garlic: 11.25 servings.

[0040] The raw materials for the powder of traditional Chinese medicine preparations include the following weight proportions: Uncaria rhynchophylla: 9 parts; Achyranthes bidentata: 8.5 parts.

[0041] The adhesive solution comprises the following parts by weight: Pharmaceutical grade gelatin: 8.5 parts; Glycerin: 1.5 parts; Sorbitol: 2.5 parts; Hydroxypropyl methylcellulose: 1.5 parts; Propylene glycol: 1.25 parts; Citric acid: 0.0625 parts; Pure water: 2.25 parts.

[0042] The preparation method for plant essential oils is as follows: Mince the garlic into small pieces less than 3mm in diameter and let it stand at 12℃ for 11 minutes. Lavender, onion, and peanut are mixed evenly in a weight ratio, and then crushed at -9℃ until the particle size is less than 9mm, and then ground until the particle size is less than 0.1mm to obtain frozen plant powder. Garlic paste and frozen plant powder were mixed evenly by weight and thawed at 22℃ for 48 minutes. Dichloromethane with a weight of 8.5 times that of garlic paste was added, and ultrasonic extraction was performed at 22℃ and 32kHz for 48 minutes. The mixture was filtered to obtain filtrate and residue. The residue was extracted four times. The filtrates were combined and allowed to stand at 32℃ and 1.2kPa for 11 hours to obtain plant essential oil.

[0043] The preparation method of traditional Chinese medicine powder is as follows: Mix Uncaria rhynchophylla and Achyranthes bidentata evenly according to the weight ratio, and grind them at -9℃ until the particle size is less than 1mm. Place the ground mixture in pure water at 21 times its weight of Uncaria rhynchophylla, bring to a boil over high heat, then simmer over low heat for 3.2 hours, and filter to remove impurities. The filtrate was allowed to stand at 32℃ and 60Pa until all the water evaporated, thus obtaining the powder of the traditional Chinese medicine preparation.

[0044] The preparation method of the adhesive solution is as follows: Pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid and pure water were mixed evenly in the weight ratio and stirred at 62℃ and 2100r / min for 95min. After cooling to 12℃, the mixture was vacuumed for 5.5 hours at -0.065MPa and passed through a 105-mesh sieve to obtain the adhesive solution.

[0045] This application also proposes a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, comprising the following steps: Step 1: Prepare plant essential oils, traditional Chinese medicine powders, and liquids according to the specified weight ratios, and set aside for later use; It is understood that in the embodiments of this application, plant essential oils, traditional Chinese medicine powders, and adhesives are prepared separately according to weight ratios and kept for later use. This ensures that the purity and activity of each raw material are not subject to cross-interference, avoids the loss due to volatilization of plant essential oils, the hygroscopic clumping of traditional Chinese medicine powders, or the impact on the stability of the adhesive system. At the same time, by precisely controlling the basic amount of each raw material through precise proportioning, a precise material foundation is laid for the subsequent mixing and encapsulation process according to specific ratios. This ensures that each core functional component (the active factors of essential oils, the efficacy components of traditional Chinese medicine powders, and the film-forming carrier of adhesives) retains its original performance completely, effectively avoids the damage to the characteristics of different materials caused by mixing and preparation, and ensures the stability of the core efficacy of the finished essential oil.

[0046] Step 2: Mix the Chinese herbal medicine powder and plant essential oil evenly according to the weight ratio. The mixing process is carried out at a stirring speed of 120r / min and a stirring time of 30min to prepare the Chinese herbal plant essential oil. It is understood that in the embodiments of this application, the traditional Chinese medicine powder and plant essential oil are mixed by weight ratio, and a stirring rate of 120 r / min and a stirring time of 30 min are used. This not only allows the effective components of the traditional Chinese medicine powder and the active factors of the plant essential oil to form a synergistic system through precise proportions, maximizing the combined efficacy of the two, but also ensures uniform mixing with appropriate stirring parameters, avoiding efficacy deviations caused by local component concentration imbalances. At the same time, gentle stirring can reduce the volatilization of plant essential oils and the destruction of effective components of traditional Chinese medicine, so that the mixed system forms a stable traditional Chinese medicine and plant essential oil matrix, providing a uniform and stable core material for the subsequent glue encapsulation process, ensuring the consistency of composition and efficacy stability of each finished product.

[0047] Step 3: The herbal plant essential oils are encapsulated in a gelatinous liquid using a pelleting machine. The pelleting process parameters are: 0.8g / pellet, temperature 20℃, and relative humidity 40%. It is understood that in this embodiment, the herbal plant essential oils are encapsulated in a gelatinous liquid using a pelleting machine. The encapsulation effect of the gelatinous liquid forms a physical protective barrier, preventing the essential oils from evaporating and being lost, and preventing the effective components of the herbal medicine from deteriorating due to external environmental factors (oxygen, humidity). Precise control of the dosage of 0.8g / pill ensures that the content of the effective components in each finished product is uniform, guaranteeing the accuracy of the dosage. The temperature of 20°C and the relative humidity of 40% provide a suitable environment for the gelatinous liquid to form a film, avoiding excessively high temperatures that cause the essential oils to evaporate, excessively low temperatures that affect the fluidity of the gelatinous liquid, excessive humidity that causes the pellets to stick together, and excessively small pellets that result in loose encapsulation. At the same time, the pelleting process makes the product into a regular shape, which is not only convenient for subsequent shaping, washing and drying operations, but also improves the quantitative convenience during use, laying the foundation for the standardized production of the finished product.

[0048] Step 4: Place the sac-pressed product in a nitrogen atmosphere at 1°C for 2 hours to set, and wash it 3 times with 95% edible alcohol. It is understood that in this embodiment, the pills are set for 2 hours in a nitrogen atmosphere at 1°C. The nitrogen atmosphere can isolate oxygen and prevent the oxidation and deterioration of the herbal plant essential oils. The low temperature environment can maintain the stability of the film and the activity of the core components, while promoting the solidification of the pill form and preventing deformation and damage during subsequent washing. Washing with 95% edible alcohol three times can effectively remove uncoated raw materials and impurities remaining on the surface of the pills, improve the purity of the product, and edible alcohol is highly safe and volatile, so it will not leave residue on the product surface, avoiding any impact on the safety of the finished product. At the same time, the clean surface of the washed pills provides a uniform and clean material state for the subsequent drying process, ensuring the uniformity of the appearance and internal quality of the finished product.

[0049] Step 5: Dry at 24℃ and 30% relative humidity for 20 hours to obtain the finished essential oil.

[0050] It is understood that in this embodiment, drying at 24℃ and 30% relative humidity for 20 hours provides a gentle drying environment that avoids high temperatures damaging the active factors of plant essential oils and the effective components of traditional Chinese medicine preparations, ensuring that the core efficacy of the finished product is not lost. Through 20 hours of continuous drying and humidity control, the moisture content of the pills can be made up to standard, inhibiting the growth of mold and bacteria, preventing the finished product from absorbing moisture and becoming moldy during storage and transportation, and extending the product's shelf life. At the same time, the dried finished pills are stable in shape, not easy to stick together and clump, making them easy to package, handle and use. The uniform moisture content ensures the storage stability and efficacy consistency of each product, avoiding quality fluctuations caused by differences in moisture content, and ultimately ensuring the comprehensive performance and use effect of the finished essential oil.

[0051] This application also proposes an application of an essential oil for relieving cardiovascular and cerebrovascular diseases, specifically for alleviating symptoms of cardiovascular and cerebrovascular circulatory disorders such as hypertension, hyperlipidemia, hyperglycemia, and coronary heart disease. Example 3

[0052] This application provides an essential oil for alleviating cardiovascular and cerebrovascular diseases. The essential oil comprises the following parts by weight: Plant essential oil ingredients: 50 parts; Traditional Chinese medicine powder raw materials: 20 parts; Adhesive solution: 27.5 parts; The plant essential oil raw materials are composed of lavender, onion, peanut, and garlic; the traditional Chinese medicine preparation powder raw materials are composed of Uncaria rhynchophylla and Achyranthes bidentata; and the adhesive liquid is composed of pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid, and purified water.

[0053] The plant essential oil raw materials include the following weight proportions: Lavender: 12.5 servings; Onions: 12.5 servings; Peanuts: 12.5 servings; Garlic: 12.5 servings.

[0054] The raw materials for the powder of traditional Chinese medicine preparations include the following weight proportions: Uncaria rhynchophylla: 10 parts; Achyranthes bidentata: 10 parts.

[0055] The adhesive solution comprises the following parts by weight: Pharmaceutical gelatin: 9 parts; Glycerin: 2 parts; Sorbitol: 3 parts; Hydroxypropyl methylcellulose: 2 parts; Propylene glycol: 1.5 parts; Citric acid: 0.075 parts; Pure water: 2.5 parts.

[0056] The preparation method for plant essential oils is as follows: Mince the garlic into small pieces less than 3mm in diameter and let it stand at 12℃ for 11 minutes. Lavender, onion, and peanut are mixed evenly in a weight ratio, and then crushed at -7℃ until the particle size is less than 9mm, and then ground until the particle size is less than 0.1mm to obtain frozen plant powder. Garlic paste and frozen plant powder were mixed evenly according to the weight ratio, thawed at 25℃ for 45 minutes, and then 9 times the weight of the garlic paste in dichloromethane was added. The mixture was ultrasonically extracted at 25℃ and 35kHz for 45 minutes. The mixture was filtered to obtain filtrate and residue. The residue was extracted 4 times. The filtrates were combined and allowed to stand at 35℃ and 1.5kPa for 11 hours to obtain plant essential oil.

[0057] The preparation method of traditional Chinese medicine powder is as follows: Mix Uncaria rhynchophylla and Achyranthes bidentata evenly according to the weight ratio, and grind them at -7℃ until the particle size is less than 1mm. Place the ground mixture in pure water at a ratio of 23 times the weight of the Uncaria rhynchophylla, bring to a boil over high heat, then simmer over low heat for 3.5 hours, and filter to remove impurities. The filtrate was allowed to stand at 35℃ and 80Pa until all the water evaporated, thus obtaining the powder of the traditional Chinese medicine preparation.

[0058] The preparation method of the adhesive solution is as follows: Pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid and pure water were mixed evenly in the weight ratio and stirred at 65℃ and 2300r / min for 90min. After cooling to 15°C, the mixture was vacuumed for 5.5 hours at -0.07 MPa and passed through a 110-mesh sieve to obtain the adhesive solution.

[0059] This application also proposes a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, comprising the following steps: Step 1: Prepare plant essential oils, traditional Chinese medicine powders, and liquids according to the specified weight ratios, and set aside for later use; It is understood that in the embodiments of this application, plant essential oils, traditional Chinese medicine powders, and adhesives are prepared separately according to weight ratios and kept for later use. This ensures that the purity and activity of each raw material are not subject to cross-interference, avoids the loss due to volatilization of plant essential oils, the hygroscopic clumping of traditional Chinese medicine powders, or the impact on the stability of the adhesive system. At the same time, by precisely controlling the basic amount of each raw material through precise proportioning, a precise material foundation is laid for the subsequent mixing and encapsulation process according to specific ratios. This ensures that each core functional component (the active factors of essential oils, the efficacy components of traditional Chinese medicine powders, and the film-forming carrier of adhesives) retains its original performance completely, effectively avoids the damage to the characteristics of different materials caused by mixing and preparation, and ensures the stability of the core efficacy of the finished essential oil.

[0060] Step 2: Mix the Chinese herbal medicine powder and plant essential oil evenly according to the weight ratio. The mixing process is carried out at a stirring speed of 120r / min and a stirring time of 30min to prepare the Chinese herbal plant essential oil. It is understood that in the embodiments of this application, the traditional Chinese medicine powder and plant essential oil are mixed by weight ratio, and a stirring rate of 120 r / min and a stirring time of 30 min are used. This not only allows the effective components of the traditional Chinese medicine powder and the active factors of the plant essential oil to form a synergistic system through precise proportions, maximizing the combined efficacy of the two, but also ensures uniform mixing with appropriate stirring parameters, avoiding efficacy deviations caused by local component concentration imbalances. At the same time, gentle stirring can reduce the volatilization of plant essential oils and the destruction of effective components of traditional Chinese medicine, so that the mixed system forms a stable traditional Chinese medicine and plant essential oil matrix, providing a uniform and stable core material for the subsequent glue encapsulation process, ensuring the consistency of composition and efficacy stability of each finished product.

[0061] Step 3: The herbal plant essential oils are encapsulated in a gelatinous liquid using a pelleting machine. The pelleting process parameters are: 0.8g / pellet, temperature 20℃, and relative humidity 40%. It is understood that in this embodiment, the herbal plant essential oils are encapsulated in a gelatinous liquid using a pelleting machine. The encapsulation effect of the gelatinous liquid forms a physical protective barrier, preventing the essential oils from evaporating and being lost, and preventing the effective components of the herbal medicine from deteriorating due to external environmental factors (oxygen, humidity). Precise control of the dosage of 0.8g / pill ensures that the content of the effective components in each finished product is uniform, guaranteeing the accuracy of the dosage. The temperature of 20°C and the relative humidity of 40% provide a suitable environment for the gelatinous liquid to form a film, avoiding excessively high temperatures that cause the essential oils to evaporate, excessively low temperatures that affect the fluidity of the gelatinous liquid, excessive humidity that causes the pellets to stick together, and excessively small pellets that result in loose encapsulation. At the same time, the pelleting process makes the product into a regular shape, which is not only convenient for subsequent shaping, washing and drying operations, but also improves the quantitative convenience during use, laying the foundation for the standardized production of the finished product.

[0062] Step 4: Place the sac-pressed product in a nitrogen atmosphere at 1°C for 2 hours to set, and wash it 3 times with 95% edible alcohol. It is understood that in this embodiment, the pills are set for 2 hours in a nitrogen atmosphere at 1°C. The nitrogen atmosphere can isolate oxygen and prevent the oxidation and deterioration of the herbal plant essential oils. The low temperature environment can maintain the stability of the film and the activity of the core components, while promoting the solidification of the pill form and preventing deformation and damage during subsequent washing. Washing with 95% edible alcohol three times can effectively remove uncoated raw materials and impurities remaining on the surface of the pills, improve the purity of the product, and edible alcohol is highly safe and volatile, so it will not leave residue on the product surface, avoiding any impact on the safety of the finished product. At the same time, the clean surface of the washed pills provides a uniform and clean material state for the subsequent drying process, ensuring the uniformity of the appearance and internal quality of the finished product.

[0063] Step 5: Dry at 24℃ and 30% relative humidity for 20 hours to obtain the finished essential oil.

[0064] It is understood that in this embodiment, drying at 24℃ and 30% relative humidity for 20 hours provides a gentle drying environment that avoids high temperatures damaging the active factors of plant essential oils and the effective components of traditional Chinese medicine preparations, ensuring that the core efficacy of the finished product is not lost. Through 20 hours of continuous drying and humidity control, the moisture content of the pills can be made up to standard, inhibiting the growth of mold and bacteria, preventing the finished product from absorbing moisture and becoming moldy during storage and transportation, and extending the product's shelf life. At the same time, the dried finished pills are stable in shape, not easy to stick together and clump, making them easy to package, handle and use. The uniform moisture content ensures the storage stability and efficacy consistency of each product, avoiding quality fluctuations caused by differences in moisture content, and ultimately ensuring the comprehensive performance and use effect of the finished essential oil.

[0065] This application also proposes an application of an essential oil for relieving cardiovascular and cerebrovascular diseases, specifically for alleviating symptoms of cardiovascular and cerebrovascular circulatory disorders such as hypertension, hyperlipidemia, hyperglycemia, and coronary heart disease. Example 4

[0066] This application provides an essential oil for alleviating cardiovascular and cerebrovascular diseases. The essential oil comprises the following parts by weight: Plant essential oil raw materials: 55 parts; Traditional Chinese medicine powder raw materials: 22.5 parts; Adhesive solution: 31.25 parts; The plant essential oil raw materials are composed of lavender, onion, peanut, and garlic; the traditional Chinese medicine preparation powder raw materials are composed of Uncaria rhynchophylla and Achyranthes bidentata; and the adhesive liquid is composed of pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid, and purified water.

[0067] The plant essential oil raw materials include the following weight proportions: Lavender: 13.75 servings; Onions: 13.75 servings; Peanuts: 13.75 servings; Garlic: 13.75 servings.

[0068] The raw materials for the powder of traditional Chinese medicine preparations include the following weight proportions: Uncaria rhynchophylla: 11 parts; Achyranthes bidentata: 11.5 parts.

[0069] The adhesive solution comprises the following parts by weight: Pharmaceutical grade gelatin: 9.5 parts; Glycerin: 2.5 parts; Sorbitol: 3.5 parts; Hydroxypropyl methylcellulose: 2.5 parts; Propylene glycol: 1.75 parts; Citric acid: 0.0875 parts; Pure water: 2.75 parts.

[0070] The preparation method for plant essential oils is as follows: Mince the garlic into small pieces less than 3mm in diameter and let it stand at 18℃ for 9 minutes. Lavender, onion, and peanut are mixed evenly in a weight ratio, and then crushed at -5℃ until the particle size is less than 9mm, and then ground until the particle size is less than 0.1mm to obtain frozen plant powder. Garlic paste and frozen plant powder were mixed evenly by weight and thawed at 28℃ for 42 minutes. Dichloromethane with a weight of 9.5 times that of garlic paste was added, and ultrasonic extraction was performed at 28℃ and 38kHz for 42 minutes. The mixture was filtered to obtain filtrate and residue. The residue was extracted 5 times. The filtrates were combined and allowed to stand at 38℃ and 1.8kPa for 10.5 hours to obtain plant essential oil.

[0071] The preparation method of traditional Chinese medicine powder is as follows: Mix Uncaria rhynchophylla and Achyranthes bidentata evenly according to the weight ratio, and grind them at -5℃ until the particle size is less than 1mm. Place the ground mixture in pure water at a ratio of 24 times the weight of the Uncaria rhynchophylla, bring to a boil over high heat, then simmer over low heat for 3.8 hours, and filter to remove impurities. The filtrate was allowed to stand at 38℃ and 90Pa until all the water evaporated, thus obtaining the powder of the traditional Chinese medicine preparation.

[0072] The preparation method of the adhesive solution is as follows: Pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid and pure water were mixed evenly in the weight ratio and stirred at 68℃ and 2400r / min for 85min. After cooling to 18°C, the mixture was vacuumed for 4.5 hours under a pressure of -0.075 MPa and then passed through a 115-mesh sieve to obtain the adhesive solution.

[0073] This application also proposes a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, comprising the following steps: Step 1: Prepare plant essential oils, traditional Chinese medicine powders, and liquids according to the specified weight ratios, and set aside for later use; It is understood that in the embodiments of this application, plant essential oils, traditional Chinese medicine powders, and adhesives are prepared separately according to weight ratios and kept for later use. This ensures that the purity and activity of each raw material are not subject to cross-interference, avoids the loss due to volatilization of plant essential oils, the hygroscopic clumping of traditional Chinese medicine powders, or the impact on the stability of the adhesive system. At the same time, by precisely controlling the basic amount of each raw material through precise proportioning, a precise material foundation is laid for the subsequent mixing and encapsulation process according to specific ratios. This ensures that each core functional component (the active factors of essential oils, the efficacy components of traditional Chinese medicine powders, and the film-forming carrier of adhesives) retains its original performance completely, effectively avoids the damage to the characteristics of different materials caused by mixing and preparation, and ensures the stability of the core efficacy of the finished essential oil.

[0074] Step 2: Mix the Chinese herbal medicine powder and plant essential oil evenly according to the weight ratio. The mixing process is carried out at a stirring speed of 120r / min and a stirring time of 30min to prepare the Chinese herbal plant essential oil. It is understood that in the embodiments of this application, the traditional Chinese medicine powder and plant essential oil are mixed by weight ratio, and a stirring rate of 120 r / min and a stirring time of 30 min are used. This not only allows the effective components of the traditional Chinese medicine powder and the active factors of the plant essential oil to form a synergistic system through precise proportions, maximizing the combined efficacy of the two, but also ensures uniform mixing with appropriate stirring parameters, avoiding efficacy deviations caused by local component concentration imbalances. At the same time, gentle stirring can reduce the volatilization of plant essential oils and the destruction of effective components of traditional Chinese medicine, so that the mixed system forms a stable traditional Chinese medicine and plant essential oil matrix, providing a uniform and stable core material for the subsequent glue encapsulation process, ensuring the consistency of composition and efficacy stability of each finished product.

[0075] Step 3: The herbal plant essential oils are encapsulated in a gelatinous liquid using a pelleting machine. The pelleting process parameters are: 0.8g / pellet, temperature 20℃, and relative humidity 40%. It is understood that in this embodiment, the herbal plant essential oils are encapsulated in a gelatinous liquid using a pelleting machine. The encapsulation effect of the gelatinous liquid forms a physical protective barrier, preventing the essential oils from evaporating and being lost, and preventing the effective components of the herbal medicine from deteriorating due to external environmental factors (oxygen, humidity). Precise control of the dosage of 0.8g / pill ensures that the content of the effective components in each finished product is uniform, guaranteeing the accuracy of the dosage. The temperature of 20°C and the relative humidity of 40% provide a suitable environment for the gelatinous liquid to form a film, avoiding excessively high temperatures that cause the essential oils to evaporate, excessively low temperatures that affect the fluidity of the gelatinous liquid, excessive humidity that causes the pellets to stick together, and excessively small pellets that result in loose encapsulation. At the same time, the pelleting process makes the product into a regular shape, which is not only convenient for subsequent shaping, washing and drying operations, but also improves the quantitative convenience during use, laying the foundation for the standardized production of the finished product.

[0076] Step 4: Place the sac-pressed product in a nitrogen atmosphere at 1°C for 2 hours to set, and wash it 3 times with 95% edible alcohol. It is understood that in this embodiment, the pills are set for 2 hours in a nitrogen atmosphere at 1°C. The nitrogen atmosphere can isolate oxygen and prevent the oxidation and deterioration of the herbal plant essential oils. The low temperature environment can maintain the stability of the film and the activity of the core components, while promoting the solidification of the pill form and preventing deformation and damage during subsequent washing. Washing with 95% edible alcohol three times can effectively remove uncoated raw materials and impurities remaining on the surface of the pills, improve the purity of the product, and edible alcohol is highly safe and volatile, so it will not leave residue on the product surface, avoiding any impact on the safety of the finished product. At the same time, the clean surface of the washed pills provides a uniform and clean material state for the subsequent drying process, ensuring the uniformity of the appearance and internal quality of the finished product.

[0077] Step 5: Dry at 24℃ and 30% relative humidity for 20 hours to obtain the finished essential oil.

[0078] It is understood that in this embodiment, drying at 24℃ and 30% relative humidity for 20 hours provides a gentle drying environment that avoids high temperatures damaging the active factors of plant essential oils and the effective components of traditional Chinese medicine preparations, ensuring that the core efficacy of the finished product is not lost. Through 20 hours of continuous drying and humidity control, the moisture content of the pills can be made up to standard, inhibiting the growth of mold and bacteria, preventing the finished product from absorbing moisture and becoming moldy during storage and transportation, and extending the product's shelf life. At the same time, the dried finished pills are stable in shape, not easy to stick together and clump, making them easy to package, handle and use. The uniform moisture content ensures the storage stability and efficacy consistency of each product, avoiding quality fluctuations caused by differences in moisture content, and ultimately ensuring the comprehensive performance and use effect of the finished essential oil.

[0079] This application also proposes an application of an essential oil for relieving cardiovascular and cerebrovascular diseases, specifically for alleviating symptoms of cardiovascular and cerebrovascular circulatory disorders such as hypertension, hyperlipidemia, hyperglycemia, and coronary heart disease. Example 5

[0080] This application provides an essential oil for alleviating cardiovascular and cerebrovascular diseases. The essential oil comprises the following parts by weight: Plant essential oil ingredients: 60 parts; Traditional Chinese medicine powder raw materials: 25 parts; Adhesive solution: 35 parts; The plant essential oil raw materials are composed of lavender, onion, peanut, and garlic; the traditional Chinese medicine preparation powder raw materials are composed of Uncaria rhynchophylla and Achyranthes bidentata; and the adhesive liquid is composed of pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid, and purified water.

[0081] The plant essential oil raw materials include the following weight proportions: Lavender: 15 servings; Onions: 15 servings; Peanuts: 15 servings; Garlic: 15 servings.

[0082] The raw materials for the powder of traditional Chinese medicine preparations include the following weight proportions: Uncaria rhynchophylla: 12 parts; Achyranthes bidentata: 13 parts.

[0083] The adhesive solution comprises the following parts by weight: Pharmaceutical gelatin: 10 parts; Glycerin: 3 parts; Sorbitol: 4 parts; Hydroxypropyl methylcellulose: 3 parts; Propylene glycol: 2 parts; Citric acid: 0.1 parts; Pure water: 3 parts.

[0084] The preparation method for plant essential oils is as follows: Mince the garlic into small pieces less than 3mm in diameter and let it stand at 20℃ for 8 minutes. Lavender, onion, and peanut are mixed evenly in a weight ratio, and then crushed at -5℃ until the particle size is less than 9mm, and then ground until the particle size is less than 0.1mm to obtain frozen plant powder. Garlic paste and frozen plant powder were mixed evenly by weight, thawed at 30℃ for 40 minutes, and then 10 times the weight of the garlic paste in dichloromethane was added. The mixture was ultrasonically extracted at 30℃ and 40kHz for 40 minutes. The mixture was filtered to obtain filtrate and residue. The residue was extracted 5 times. The filtrates were combined and allowed to stand at 40℃ and 2kPa for 10 hours to obtain plant essential oil.

[0085] The preparation method of traditional Chinese medicine powder is as follows: Mix Uncaria rhynchophylla and Achyranthes bidentata evenly according to the weight ratio, and grind them at -5℃ until the particle size is less than 1mm. Place the ground mixture in pure water at 25 times its weight of Uncaria rhynchophylla, bring to a boil over high heat, then simmer over low heat for 4 hours, and filter to remove impurities. The filtrate was allowed to stand at 40℃ and 100Pa until all the water evaporated, thus obtaining the powder of the traditional Chinese medicine preparation.

[0086] The preparation method of the adhesive solution is as follows: Pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid and pure water were mixed evenly in the weight ratio and stirred for 80 min at 70℃ and 2500 r / min. After cooling to 20℃, the solution was vacuumed for 4 hours under -0.08MPa conditions and passed through a 120-mesh sieve to obtain the adhesive solution.

[0087] This application also proposes a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, comprising the following steps: Step 1: Prepare plant essential oils, traditional Chinese medicine powders, and liquids according to the specified weight ratios, and set aside for later use; It is understood that in the embodiments of this application, plant essential oils, traditional Chinese medicine powders, and adhesives are prepared separately according to weight ratios and kept for later use. This ensures that the purity and activity of each raw material are not subject to cross-interference, avoids the loss due to volatilization of plant essential oils, the hygroscopic clumping of traditional Chinese medicine powders, or the impact on the stability of the adhesive system. At the same time, by precisely controlling the basic amount of each raw material through precise proportioning, a precise material foundation is laid for the subsequent mixing and encapsulation process according to specific ratios. This ensures that each core functional component (the active factors of essential oils, the efficacy components of traditional Chinese medicine powders, and the film-forming carrier of adhesives) retains its original performance completely, effectively avoids the damage to the characteristics of different materials caused by mixing and preparation, and ensures the stability of the core efficacy of the finished essential oil.

[0088] Step 2: Mix the Chinese herbal medicine powder and plant essential oil evenly according to the weight ratio. The mixing process is carried out at a stirring speed of 120r / min and a stirring time of 30min to prepare the Chinese herbal plant essential oil. It is understood that in the embodiments of this application, the traditional Chinese medicine powder and plant essential oil are mixed by weight ratio, and a stirring rate of 120 r / min and a stirring time of 30 min are used. This not only allows the effective components of the traditional Chinese medicine powder and the active factors of the plant essential oil to form a synergistic system through precise proportions, maximizing the combined efficacy of the two, but also ensures uniform mixing with appropriate stirring parameters, avoiding efficacy deviations caused by local component concentration imbalances. At the same time, gentle stirring can reduce the volatilization of plant essential oils and the destruction of effective components of traditional Chinese medicine, so that the mixed system forms a stable traditional Chinese medicine and plant essential oil matrix, providing a uniform and stable core material for the subsequent glue encapsulation process, ensuring the consistency of composition and efficacy stability of each finished product.

[0089] Step 3: The herbal plant essential oils are encapsulated in a gelatinous liquid using a pelleting machine. The pelleting process parameters are: 0.8g / pellet, temperature 20℃, and relative humidity 40%. It is understood that in this embodiment, the herbal plant essential oils are encapsulated in a gelatinous liquid using a pelleting machine. The encapsulation effect of the gelatinous liquid forms a physical protective barrier, preventing the essential oils from evaporating and being lost, and preventing the effective components of the herbal medicine from deteriorating due to external environmental factors (oxygen, humidity). Precise control of the dosage of 0.8g / pill ensures that the content of the effective components in each finished product is uniform, guaranteeing the accuracy of the dosage. The temperature of 20°C and the relative humidity of 40% provide a suitable environment for the gelatinous liquid to form a film, avoiding excessively high temperatures that cause the essential oils to evaporate, excessively low temperatures that affect the fluidity of the gelatinous liquid, excessive humidity that causes the pellets to stick together, and excessively small pellets that result in loose encapsulation. At the same time, the pelleting process makes the product into a regular shape, which is not only convenient for subsequent shaping, washing and drying operations, but also improves the quantitative convenience during use, laying the foundation for the standardized production of the finished product.

[0090] Step 4: Place the sac-pressed product in a nitrogen atmosphere at 1°C for 2 hours to set, and wash it 3 times with 95% edible alcohol. It is understood that in this embodiment, the pills are set for 2 hours in a nitrogen atmosphere at 1°C. The nitrogen atmosphere can isolate oxygen and prevent the oxidation and deterioration of the herbal plant essential oils. The low temperature environment can maintain the stability of the film and the activity of the core components, while promoting the solidification of the pill form and preventing deformation and damage during subsequent washing. Washing with 95% edible alcohol three times can effectively remove uncoated raw materials and impurities remaining on the surface of the pills, improve the purity of the product, and edible alcohol is highly safe and volatile, so it will not leave residue on the product surface, avoiding any impact on the safety of the finished product. At the same time, the clean surface of the washed pills provides a uniform and clean material state for the subsequent drying process, ensuring the uniformity of the appearance and internal quality of the finished product.

[0091] Step 5: Dry at 24℃ and 30% relative humidity for 20 hours to obtain the finished essential oil.

[0092] It is understood that in this embodiment, drying at 24℃ and 30% relative humidity for 20 hours provides a gentle drying environment that avoids high temperatures damaging the active factors of plant essential oils and the effective components of traditional Chinese medicine preparations, ensuring that the core efficacy of the finished product is not lost. Through 20 hours of continuous drying and humidity control, the moisture content of the pills can be made up to standard, inhibiting the growth of mold and bacteria, preventing the finished product from absorbing moisture and becoming moldy during storage and transportation, and extending the product's shelf life. At the same time, the dried finished pills are stable in shape, not easy to stick together and clump, making them easy to package, handle and use. The uniform moisture content ensures the storage stability and efficacy consistency of each product, avoiding quality fluctuations caused by differences in moisture content, and ultimately ensuring the comprehensive performance and use effect of the finished essential oil.

[0093] This application also proposes an application of an essential oil for relieving cardiovascular and cerebrovascular diseases, specifically for alleviating symptoms of cardiovascular and cerebrovascular circulatory disorders such as hypertension, hyperlipidemia, hyperglycemia, and coronary heart disease.

[0094] The preparation method of this embodiment is the same as that of Embodiment 1.

[0095] Comparative Example 1 This comparative example provides a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, which mainly includes the following preparation steps: (1) Preparation of plant essential oil: Onion and peanut are mixed evenly at a mass ratio of 1.5:1. They are first crushed to a particle size of less than 9 mm at an ambient temperature of -8℃ and then placed in a grinder and ground at an ambient temperature of -8℃ to a particle size of less than 0.1 mm to obtain frozen plant powder. Garlic is chopped into garlic paste with a particle size of less than 3 mm and left to stand at 15℃ for 10 min. Garlic paste and frozen plant powder are mixed evenly at a mass ratio of 1:3.5 and thawed at 25℃ for 45 min. Dichloromethane with a mass ratio of 9 times that of garlic paste is added for extraction. The extraction is carried out at 25℃ and 35kHz ultrasonic extraction for 45 min. The filtrate and residue are obtained by filtration. The residue is extracted with dichloromethane 4 times. The filtrates from multiple extractions are combined and left to stand at 35℃ and 1.5kPa for 11 h to obtain plant essential oil. (2) Preparation of Chinese medicine powder: Uncaria rhynchophylla and Achyranthes bidentata are mixed evenly at a mass ratio of 1:1.5 and ground at -8℃ until the particle size is less than 1mm. The mixture is placed in pure water with a mass of 22 times that of Uncaria rhynchophylla, and boiled over high heat in a clay pot. Then, it is simmered over low heat for 3.5 hours. After filtering to remove impurities, the mixture is allowed to stand at 35℃ and 80Pa until the water is completely evaporated to obtain Chinese medicine powder. (3) Pill making: Mix the Chinese medicine preparation powder and plant essential oil at a mass ratio of 1:7 to prepare Chinese medicine plant essential oil; mix the medicinal gelatin, glycerin and pure water at a mass ratio of 9:2:2.5, stir at 65℃ and 2200r / min for 90min, cool to 15℃, vacuum at -0.07MPa for 5h, and pass through a 110-mesh sieve to obtain the gel solution; use a pill making machine to press the Chinese medicine plant essential oil into the gel solution, with a filling amount of 0.9g / pill, temperature 22℃, relative humidity 45%, and place at 5℃ for 1.5h in a nitrogen atmosphere to set the shape, then wash with 95% edible alcohol 4 times, and dry at 26℃ and 35% relative humidity for 18h to obtain the essential oil for relieving cardiovascular and cerebrovascular diseases.

[0096] Comparative Example 2 This comparative example provides a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, which mainly includes the following preparation steps: (1) Preparation of plant essential oil: Lavender and peanuts were mixed evenly at a mass ratio of 1:1. They were first crushed to a particle size of less than 9 mm at an ambient temperature of -8℃ and then placed in a grinder and ground at an ambient temperature of -8℃ to a particle size of less than 0.1 mm to obtain frozen plant powder. Garlic was chopped into garlic paste with a particle size of less than 3 mm and left to stand at 15℃ for 10 min. The garlic paste and frozen plant powder were mixed evenly at a mass ratio of 1:3.5 and thawed at 25℃ for 45 min. Dichloromethane with a mass ratio of 9 times that of garlic paste was added for extraction. The extraction was carried out at 25℃ and 35kHz for 45 min. The filtrate and residue were obtained by filtration. The residue was extracted with dichloromethane 4 times. The filtrates from the multiple extractions were combined and left to stand at 35℃ and 1.5 kPa for 11 h to obtain plant essential oil. (2) Preparation of Chinese medicine powder: Uncaria rhynchophylla and Achyranthes bidentata are mixed evenly at a mass ratio of 1:1.5 and ground at -8℃ until the particle size is less than 1mm. The mixture is placed in pure water with a mass of 22 times that of Uncaria rhynchophylla, and boiled over high heat in a clay pot. Then, it is simmered over low heat for 3.5 hours. After filtering to remove impurities, the mixture is allowed to stand at 35℃ and 80Pa until the water is completely evaporated to obtain Chinese medicine powder. (3) Pill making: Mix the Chinese medicine preparation powder and plant essential oil at a mass ratio of 1:7 to prepare Chinese medicine plant essential oil; mix the medicinal gelatin, glycerin and pure water at a mass ratio of 9:2:2.5, stir at 65℃ and 2200r / min for 90min, cool to 15℃, vacuum at -0.07MPa for 5h, and pass through a 110-mesh sieve to obtain the gel solution; use a pill making machine to press the Chinese medicine plant essential oil into the gel solution, with a filling amount of 0.9g / pill, temperature 22℃, relative humidity 45%, and place at 5℃ for 1.5h in a nitrogen atmosphere to set the shape, then wash with 95% edible alcohol 4 times, and dry at 26℃ and 35% relative humidity for 18h to obtain the essential oil for relieving cardiovascular and cerebrovascular diseases.

[0097] Comparative Example 3 This comparative example provides a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, which mainly includes the following preparation steps: (1) Preparation of plant essential oil: Lavender and onion were mixed evenly at a mass ratio of 1:1.5. They were first crushed to a particle size of less than 9 mm at an ambient temperature of -8℃ and then placed in a grinder and ground at an ambient temperature of -8℃ to a particle size of less than 0.1 mm to obtain frozen plant powder. Garlic was chopped into garlic paste with a particle size of less than 3 mm and left to stand at 15℃ for 10 min. The garlic paste and frozen plant powder were mixed evenly at a mass ratio of 1:3.5 and thawed at 25℃ for 45 min. Dichloromethane with a mass ratio of 9 times that of garlic paste was added for extraction. The extraction was carried out at 25℃ and 35kHz ultrasonic extraction for 45 min. The filtrate and residue were obtained by filtration. The residue was extracted with dichloromethane 4 times. The filtrates from the multiple extractions were combined and left to stand at 35℃ and 1.5 kPa for 11 h to obtain plant essential oil. (2) Preparation of Chinese medicine powder: Uncaria rhynchophylla and Achyranthes bidentata are mixed evenly at a mass ratio of 1:1.5 and ground at -8℃ until the particle size is less than 1mm. The mixture is placed in pure water with a mass of 22 times that of Uncaria rhynchophylla, and boiled over high heat in a clay pot. Then, it is simmered over low heat for 3.5 hours. After filtering to remove impurities, the mixture is allowed to stand at 35℃ and 80Pa until the water is completely evaporated to obtain Chinese medicine powder. (3) Pill making: Mix the Chinese medicine preparation powder and plant essential oil at a mass ratio of 1:7 to prepare Chinese medicine plant essential oil; mix the medicinal gelatin, glycerin and pure water at a mass ratio of 9:2:2.5, stir at 65℃ and 2200r / min for 90min, cool to 15℃, vacuum at -0.07MPa for 5h, and pass through a 110-mesh sieve to obtain the gel solution; use a pill making machine to press the Chinese medicine plant essential oil into the gel solution, with a filling amount of 0.9g / pill, temperature 22℃, relative humidity 45%, and place at 5℃ for 1.5h in a nitrogen atmosphere to set the shape, then wash with 95% edible alcohol 4 times, and dry at 26℃ and 35% relative humidity for 18h to obtain the essential oil for relieving cardiovascular and cerebrovascular diseases.

[0098] Comparative Example 4 This comparative example provides a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, which mainly includes the following preparation steps: (1) Preparation of plant essential oil: Lavender, onion and peanut are mixed evenly in a mass ratio of 1:1.5:1. The mixture is first crushed to a particle size of less than 9 mm at an ambient temperature of -8℃ and then placed in a grinder and ground to a particle size of less than 0.1 mm at an ambient temperature of -8℃ to obtain frozen plant powder. The frozen plant powder is thawed at 25℃ for 45 min and extracted with dichloromethane at a mass of 2.5 times that of the frozen plant powder. The extraction is carried out at 25℃ and 35kHz for 45 min. The filtrate and residue are obtained by filtration. The residue is extracted with dichloromethane 4 times. The filtrates from the multiple extractions are combined and allowed to stand at 35℃ and 1.5kPa for 11 h to obtain plant essential oil. (2) Preparation of Chinese medicine powder: Uncaria rhynchophylla and Achyranthes bidentata are mixed evenly at a mass ratio of 1:1.5 and ground at -8℃ until the particle size is less than 1mm. The mixture is placed in pure water with a mass of 22 times that of Uncaria rhynchophylla, and boiled over high heat in a clay pot. Then, it is simmered over low heat for 3.5 hours. After filtering to remove impurities, the mixture is allowed to stand at 35℃ and 80Pa until the water is completely evaporated to obtain Chinese medicine powder. (3) Pill making: Mix the Chinese medicine preparation powder and plant essential oil at a mass ratio of 1:7 to prepare Chinese medicine plant essential oil; mix the medicinal gelatin, glycerin and pure water at a mass ratio of 9:2:2.5, stir at 65℃ and 2200r / min for 90min, cool to 15℃, vacuum at -0.07MPa for 5h, and pass through a 110-mesh sieve to obtain the gel solution; use a pill making machine to press the Chinese medicine plant essential oil into the gel solution, with a filling amount of 0.9g / pill, temperature 22℃, relative humidity 45%, and place at 5℃ for 1.5h in a nitrogen atmosphere to set the shape, then wash with 95% edible alcohol 4 times, and dry at 26℃ and 35% relative humidity for 18h to obtain the essential oil for relieving cardiovascular and cerebrovascular diseases.

[0099] Comparative Example 5 This comparative example provides a method for preparing an essential oil for alleviating cardiovascular and cerebrovascular diseases, which mainly includes the following preparation steps: (1) Preparation of plant essential oil: Lavender, onion and peanut are mixed evenly in a mass ratio of 1:1.5:1. They are first crushed to a particle size of less than 9 mm at an ambient temperature of -8℃ and then placed in a grinder and ground to a particle size of less than 0.1 mm at an ambient temperature of -8℃ to obtain frozen plant powder. Garlic is chopped into garlic paste with a particle size of less than 3 mm and left to stand at 15℃ for 10 min. The garlic paste and frozen plant powder are mixed evenly in a mass ratio of 1:3.5 and thawed at 25℃ for 45 min. Dichloromethane with a mass ratio of 9 times that of garlic paste is added for extraction. The extraction is carried out at 25℃ and 35kHz ultrasonic extraction for 45 min. The filtrate and residue are obtained by filtration. The residue is extracted with dichloromethane 4 times. The filtrates from multiple extractions are combined and left to stand at 35℃ and 1.5 kPa for 11 h to obtain plant essential oil. (2) Pill making: Mix pharmaceutical gelatin, glycerin and pure water in a mass ratio of 9:2:2.5. Stir at 2200r / min for 90min at 65℃. After cooling to 15℃, vacuum at -0.07MPa for 5h. Pass through a 110-mesh sieve to obtain a gel solution. Press the plant essential oil into the gel solution using a pill making machine. The amount is 0.9g / pill. The temperature is 22℃ and the relative humidity is 45%. Place it in a nitrogen atmosphere at 5℃ for 1.5h to set the shape. Then wash it 4 times with 95% edible alcohol. Dry it at 26℃ and 35% relative humidity for 18h to obtain an essential oil for relieving cardiovascular and cerebrovascular diseases. Performance testing

[0100] Animal model experiments were used to analyze the cardiovascular and cerebrovascular regulatory effects of the essential oils prepared in Examples 1-5 and Comparative Examples 1-5. Sixty-six model mice fed a high-salt, high-fat, and high-sugar diet for one month were randomly divided into 11 groups and fed the essential oils of Examples 1-5 and Comparative Examples 1-5 (mixed with conventional food, with the same single feeding dose) for 7 consecutive days. The decrease rate of blood pressure, blood sugar, blood lipids and the improvement rate of blood viscosity were detected. The performance test data are shown in Table 1.

[0101] Table 1. Test on the regulatory effect of cardiovascular and cerebrovascular indicators (7 days) Material Blood pressure reduction rate (%) Blood glucose reduction rate (%) Blood lipid reduction rate (%) Example 1 21.2 23.1 17.6 Example 2 21.4 23.2 17.5 Example 3 21.5 23.3 17.7 Example 4 21.3 23.2 17.6 Example 5 21.1 23.3 17.8 Comparative Example 1 18.2 23.2 11.2 Comparative Example 2 17.5 18.8 13.3 Comparative Example 3 19.1 20.6 15.8 Comparative Example 4 19.7 21.3 16.2 Comparative Example 5 12.3 20.2 15.3 As shown in Table 1, the essential oils prepared in Examples 1-5 of this invention showed excellent performance in regulating cardiovascular and cerebrovascular indicators, with a blood pressure reduction rate of 21.1%-21.5%, a blood sugar reduction rate of 23.1%-23.3%, a blood lipid reduction rate of 17.5%-17.8%, and a blood viscosity improvement rate of 19.8%-20.5%. All indicators were significantly better than those in Comparative Examples 1-5. In the examples, the plant essential oils (lavender, onion, peanut, and garlic) and traditional Chinese medicine powders (Uncaria and Achyranthes) were scientifically formulated. Allicin inhibited ACE activity, linalool from lavender dilated blood vessels, rhizome alkaloid blocked calcium ion channels, and Achyranthes polysaccharides improved blood rheology, resulting in a comprehensive relief of cardiovascular and cerebrovascular circulatory disorders. However, the comparative examples, due to the absence of key components or improper process parameters, suffered from a loss of synergistic effects and a significant decline in regulatory efficacy: Comparative Example 1, lacking lavender, showed a lipid reduction rate of only 11.2%; Comparative Example 2, lacking onion, showed a blood glucose reduction rate of only 18.8%; Comparative Example 3, lacking peanut, had all indicators at moderate levels; Comparative Example 4, without the low-temperature static activation process for garlic and without adding garlic paste, resulted in insufficient release of active ingredients and limited regulatory effects; Comparative Example 5, lacking traditional Chinese medicine powder, showed a blood pressure reduction rate of only 12.3%, the lowest among all test groups, fully demonstrating the importance of the complete combination of plant essential oil components and their synergistic effect with traditional Chinese medicine preparations.

[0102] The controlled-release effect of the essential oils prepared in Examples 1-5 and Comparative Examples 1-5 was analyzed by in vitro dissolution test. The gastric juice (pH 1.2) and intestinal juice (pH 6.8) environments of human body were simulated. The cumulative release rate of the essential oils at 2h (gastric juice environment), 12h (intestinal juice environment) and 24h (intestinal juice environment) was detected. The performance test data are shown in Table 2.

[0103] Table 2. Intestinal Targeted Controlled Release Efficacy Test Material Cumulative release rate over 2 hours (%) Cumulative release rate over 12 hours (%) 24-hour cumulative release rate (%) Example 1 28.5 89.2 98.5 Example 2 29.3 90.5 98.8 Example 3 30.1 91.8 99.0 Example 4 29.7 91.2 98.9 Example 5 32.1 93.6 99.2 Comparative Example 1 35.7 78.3 89.5 Comparative Example 2 36.2 76.5 88.2 Comparative Example 3 34.9 80.1 90.3 Comparative Example 4 37.5 75.8 87.6 Comparative Example 5 38.2 74.5 86.8 As shown in Table 2, the essential oils prepared in Examples 1-5 of this invention exhibit excellent intestinal targeted controlled release performance: the cumulative release rate in the gastric fluid environment is only 28.5%-32.1% in 2 hours, avoiding the destruction of active ingredients by gastric acid; the cumulative release rate in the intestinal fluid environment reaches 89.2%-93.6% in 12 hours, and the cumulative release rate in 24 hours is ≥98.5%, achieving continuous and stable release of active ingredients. This is due to the three-dimensional network structure formed by the gel coating system (pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, etc.), where each component synergistically regulates the swelling rate to achieve targeted release into the intestine. In contrast, the control-release effect was impaired due to the absence of gel components or an imbalance in the ratio of plant essential oils in the comparative examples: Comparative examples 1-3 lacked some plant essential oil components, affecting the system compatibility; Comparative example 4 did not add garlic paste and had poor compatibility with extraction process parameters; Comparative example 5 lacked key film-forming aids such as hydroxypropyl methylcellulose and sorbitol, resulting in insufficient density of the coating structure, excessively rapid release in gastric juice (38.2% in comparative example 5), and insufficient release in intestinal juice (only 74.5% in comparative example 5 after 12 hours), leading to fluctuations in blood drug concentration, affecting efficacy and increasing safety risks.

[0104] The stability of the essential oils prepared in Examples 1-5 and Comparative Examples 1-5 was analyzed by long-term storage test. The samples were stored at room temperature (25°C) and sealed for 12 months. The average retention rate of the active ingredients (allicin, rhizoma lysine, oleanolic acid) was detected. The performance test data are shown in Table 3.

[0105] Table 3 Product stability test (12 months) Material Average retention rate of active ingredients (%) Appearance changes Hardness change Example 1 91.8 No significant changes No significant changes Example 2 92.5 No significant changes No significant changes Example 3 93.2 No significant changes No significant changes Example 4 93.0 No significant changes No significant changes Example 5 93.8 No significant changes No significant changes Comparative Example 1 78.5 Slightly yellowing Slightly softened Comparative Example 2 76.3 Slightly yellowing Slightly softened Comparative Example 3 80.2 Slight discoloration No significant changes Comparative Example 4 74.8 Noticeably turned yellow Noticeably softened Comparative Example 5 73.5 Noticeably yellow and sticky Significantly softened As shown in Table 3, the essential oils prepared in Examples 1-5 of this invention exhibit significantly better stability than those in Comparative Examples 1-5: after 12 months of sealed storage at room temperature, the average retention rate of active ingredients reached 91.8%-93.8%, with no significant changes in appearance or hardness. The dense coating layer formed by the gel blocked oxygen, moisture, and light, and, combined with low-temperature pulverization, ultrasonic extraction, and gentle drying processes, prevented the oxidation, loss, and degradation of active ingredients. In contrast, the comparative examples showed a significant decrease in stability due to the absence of core components or improper process parameters: Comparative Examples 1-3 lacked some plant essential oils, weakening the synergistic protective effect between components; Comparative Example 4 did not add garlic paste, and the extraction process did not guarantee the stability of active ingredients; Comparative Example 5 lacked traditional Chinese medicine powder, and the gel had poor film-forming properties, resulting in an incomplete protective barrier and an effective ingredient retention rate of only 73.5%, with obvious yellowing, stickiness, and significant softening of hardness, severely affecting the long-term effectiveness of the product.

[0106] The green production indicators of the essential oils prepared in Examples 1-5 and Comparative Examples 1-5 were analyzed using the process parameter detection method. The utilization rate of industrial solid waste, solvent (dichloromethane) recovery rate and energy consumption per unit product were tested. The performance test data are shown in Table 4.

[0107] Table 4 Green Production Indicator Test Material Industrial solid waste utilization rate (%) Solvent recovery rate (%) Energy consumption per unit product (kWh / t) Example 1 90 90 120 Example 2 91 91 118 Example 3 92 92 115 Example 4 91 91 117 Example 5 92 93 114 Comparative Example 1 90 85 135 Comparative Example 2 90 84 138 Comparative Example 3 88 86 132 Comparative Example 4 87 83 140 Comparative Example 5 85 82 142 As shown in Table 4, the essential oils prepared in Examples 1-5 of this invention conform to the concept of green production: the utilization rate of industrial solid waste reaches 90%-92%, the recovery rate of dichloromethane is ≥90%, and the energy consumption per unit product is only 114-120 kWh / t. The ultrasonic extraction process efficiently utilizes and recycles solvents, and the residue of traditional Chinese medicine can be used as raw material for organic fertilizer. There is no solid waste discharge, and the preparation process does not require high-temperature calcination. In contrast, the comparative examples show a weakening of green production advantages due to component adjustments or decreased process adaptability: the extraction efficiency of comparative examples 1-3 is reduced due to the lack of plant essential oil components; the solvent consumption of comparative example 4 is increased due to the absence of garlic paste and improper extraction parameters; comparative example 5 lacks traditional Chinese medicine preparation powder, resulting in an incomplete process chain, leading to a solvent recovery rate of only 82%-86%, an energy consumption per unit product of 132-142 kWh / t, and a reduction in the utilization rate of industrial solid waste to 85%-90%, resulting in a significant decrease in environmental benefits.

[0108] In summary, this application's embodiments, through the multi-target synergistic regulatory effects of plant essential oils and traditional Chinese medicine powder, the targeted controlled release and protective effects of the gel coating system, and the optimization of green processes such as ultrasonic extraction, have prepared a high-performance cardiovascular regulatory essential oil: The scientifically formulated blend of plant essential oils (allicin, linalool, etc.) and traditional Chinese medicine powder, through multi-target synergistic effects such as inhibiting ACE activity and dilating blood vessels, resulted in excellent regulatory effects in model mouse experiments (blood pressure reduction rate 21.1%-21.5%, blood glucose reduction rate 23.1%-23.3%, blood lipid reduction rate 17.5%-17.8%, blood viscosity improvement rate 19.8%-20.5%), significantly superior to comparative examples (e.g., comparative example 1 blood lipid reduction rate 11.2%, comparative example 2 blood glucose reduction rate 18.8%), the latter losing synergistic effects due to the absence of key components; the three-dimensional network structure formed by gel coating regulates the swelling rate, achieving targeted controlled release in the intestine (…). The cumulative release rate of gastric juice over 2 hours was 28.5%-32.1%, avoiding destruction by gastric acid; the release rate of intestinal juice over 12 hours was 89.2%-93.6%, and the continuous release over 24 hours was ≥98.5%. In contrast, the release was abnormal due to impaired coating or synergistic effects (Comparative Example 4: 37.5% release from gastric juice, only 75.8% from intestinal juice over 12 hours). The dense coating of the gel, combined with a low-temperature process, ensured that the effective components of the essential oil retained at 91.8%-93.8% after 12 months of sealed storage at 25℃. The product exhibits stable properties, far superior to the comparative example (retention rate 74.8%-80.2%, some parts yellowed and softened); ultrasonic extraction and other processes enable the utilization rate of solid waste in the essential oil industry to reach 90%-92%, dichloromethane recovery rate ≥90%, and unit product energy consumption of 114-120kWh / t. The comparative example, due to decreased process adaptability, showed deterioration (solvent recovery rate 83%-86%, energy consumption 132-140kWh / t), thus enhancing the application performance of essential oils in the field of cardiovascular regulation.

[0109] According to the embodiments of this application, an essential oil for alleviating cardiovascular and cerebrovascular diseases and its preparation method are proposed. This involves combining plant essential oils (garlic 10-20℃ static activator for allicin, lavender linalool, onion prostaglandin A, etc.) with traditional Chinese medicine powders (uncaria rhynchophylla, Achyranthes bidentata polysaccharide, etc.), using ultrasonic cavitation and low-temperature extraction to ensure activity, thereby achieving a decrease in blood pressure / blood sugar / blood lipids and an improvement in blood viscosity (e.g., a blood pressure reduction rate of 21.1%-21.5%). A three-dimensional network structure is constructed using a gel (pharmaceutical gelatin, hydroxypropyl methylcellulose, etc.), and the swelling rate is adjusted to achieve targeted release into the intestine (gastric juice release rate of 28.5%-32.1% in 2 hours to avoid damage, intestinal juice release rate of 89.2%-93.6% in 12 hours, and ≥98% in 24 hours). The formula features a 0.5% sustained release rate, reducing the risk of fluctuations in blood drug concentration. Dense gel coating combined with low-temperature processing ensures a 91.8%-93.8% retention rate of active ingredients after 12 months of sealed storage at 25℃, significantly superior to uncoated products (65% retention rate at 6 months) and traditional Chinese medicine pills (83.0% retention rate at 12 months). Natural raw materials and controlled-release design enhance safety; acute (5g / kg via gavage in mice) and long-term (1g / kg·d × 90 days via gavage in rats) toxicity tests showed no abnormalities, and the incidence of mild diarrhea was lower than that of traditional pills (15%). 30-40kHz ultrasonic extraction combined with dichloromethane recovery (≥90%) and utilization of the residue as organic fertilizer achieves an industrial solid waste utilization rate of ≥90% and low-energy, green production. Integrating these processes enables precise control of essential oil activity, controlled release, stability, safety, and green production, overcoming the technical bottlenecks of traditional essential oils such as poor targeting, insufficient stability, limited safety, and high production pollution, thus improving cardiovascular regulation effects and product application value.

[0110] Although embodiments of this application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the appended claims and their equivalents.

[0111] The present application and its embodiments have been described above. This description is not restrictive, and the actual application is not limited thereto. In conclusion, if a person skilled in the art is inspired by this description and designs a similar structure and embodiment without departing from the spirit of this application, such design should fall within the protection scope of this application.

Claims

1. An essential oil for relieving cardiovascular and cerebrovascular diseases, characterized in that, The essential oil comprises the following parts by weight: Plant essential oil ingredients: 40-60 parts; Traditional Chinese medicine powder raw materials: 15-25 parts; Adhesive solution: 20-35 parts; The plant essential oil raw materials are composed of lavender, onion, peanut, and garlic; the traditional Chinese medicine preparation powder raw materials are composed of Uncaria rhynchophylla and Achyranthes bidentata; and the adhesive liquid is composed of pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid, and purified water.

2. The essential oil for relieving cardiovascular and cerebrovascular diseases according to claim 1, characterized in that, The plant essential oil raw materials comprise the following parts by weight: Lavender: 10-15 parts; Onions: 10-15 servings; Peanuts: 10-15 servings; Garlic: 10-15 servings.

3. The essential oil for relieving cardiovascular and cerebrovascular diseases according to claim 1, characterized in that, The powder raw materials for the traditional Chinese medicine preparation include the following weight proportions: Uncaria rhynchophylla: 8-12 parts; Achyranthes bidentata: 7-13 parts.

4. The essential oil for relieving cardiovascular and cerebrovascular diseases according to claim 1, characterized in that, The adhesive comprises the following parts by weight: Pharmaceutical grade gelatin: 8-10 parts; Glycerin: 1-3 parts; Sorbitol: 2-4 parts; Hydroxypropyl methylcellulose: 1-3 parts; Propylene glycol: 1-2 parts; Citric acid: 0.05-0.1 parts; Pure water: 2-3 parts.

5. The essential oil for relieving cardiovascular and cerebrovascular diseases according to claim 1, characterized in that, The preparation method of the plant essential oil raw material is as follows: Mince the garlic into small pieces less than 3mm in diameter and let it stand at 10-20℃ for 8-12 minutes. Lavender, onion, and peanut are mixed evenly in a weight ratio, and then pulverized at -10 to 5℃ until the particle size is less than 9mm, and then ground until the particle size is less than 0.1mm to obtain frozen plant powder. Mix minced garlic and frozen plant powder evenly according to the weight ratio, thaw at 20-30℃ for 40-50 minutes, add 8-10 times the weight of the minced garlic in dichloromethane, and extract ultrasonically at 20-30℃ and 30-40kHz for 40-50 minutes. Filter to obtain filtrate and residue. Repeat the extraction of residue 3-5 times, combine the filtrates, and let stand at 30-40℃ and 1-2kPa for 10-12 hours to obtain plant essential oil.

6. The essential oil for relieving cardiovascular and cerebrovascular diseases according to claim 1, characterized in that, The preparation method of the powder raw material for the traditional Chinese medicine preparation is as follows: Mix Uncaria rhynchophylla and Achyranthes bidentata evenly according to the weight ratio, and grind them at -10-5℃ until the particle size is less than 1mm. Place the ground mixture in pure water at 20-25 times its weight of Uncaria rhynchophylla, bring to a boil over high heat, then simmer over low heat for 3-4 hours, and filter to remove impurities. The filtrate was allowed to stand at 30-40℃ and 50-100Pa until all the water evaporated, thus obtaining the powder of the traditional Chinese medicine preparation.

7. The essential oil for relieving cardiovascular and cerebrovascular diseases according to claim 1, characterized in that, The preparation method of the adhesive solution is as follows: Mix pharmaceutical gelatin, glycerin, sorbitol, hydroxypropyl methylcellulose, propylene glycol, citric acid and pure water in a uniform weight ratio, and stir for 80-100 minutes at 60-70℃ and 2000-2500r / min. After cooling to 10-20℃, vacuum is applied for 4-6 hours under -0.06-0.08MPa conditions, and the solution is passed through a 100-120 mesh sieve to obtain the adhesive solution.

8. A method for preparing an essential oil for relieving cardiovascular and cerebrovascular diseases as described in any one of claims 1-7, characterized in that, Includes the following steps: Step 1: Prepare plant essential oils, traditional Chinese medicine powders, and liquids according to the specified weight ratios, and set aside for later use; Step 2: Mix the Chinese herbal medicine powder and plant essential oil evenly according to the weight ratio to prepare Chinese herbal plant essential oil; Step 3: The herbal plant essential oils are encapsulated in a gelatinous solution using a pelleting machine. The pelleting process parameters are: weight 0.8-1g / pellet, temperature 20-24℃, relative humidity 40-50%. Step 4: Place the sac-pressed product in a nitrogen atmosphere at 1-10℃ for 1-2 hours to set, and wash it with 95% edible alcohol 3-5 times. Step 5: Dry at 24-30℃ and 30-40% relative humidity for 15-20 hours to obtain the finished essential oil.

9. The method for preparing essential oil for relieving cardiovascular and cerebrovascular diseases according to claim 8, characterized in that, In step two, the mixing process uses a stirring rate of 120-150 r / min and a stirring time of 20-30 min to ensure uniform mixing.

10. The application of an essential oil for relieving cardiovascular and cerebrovascular diseases as described in any one of claims 1-7, characterized in that, It is used to relieve symptoms of cardiovascular and cerebrovascular circulatory disorders caused by hypertension, hyperlipidemia, hyperglycemia, and coronary heart disease.

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