Hyaluronic acid wolfberry micromolecule stock solution production equipment based on electron irradiation

Abstract

The invention discloses a hyaluronic acid wolfberry micromolecule stock solution production device based on electron irradiation, which comprises a high-speed shearing emulsifying machine used for crushing, homogenizing and emulsifying soaked wolfberry to obtain a wolfberry solution; the multi-stage filtering structure is used for performing multi-stage filtering on the Chinese wolfberry fruit liquid to obtain a small-molecular-grade Chinese wolfberry fruit stock solution; the compounding machine is used for stirring and compounding the micromolecular wolfberry stock solution and the sodium hyaluronate dissolving solution to obtain a compounded solution; and the irradiation generator is used for carrying out cold sterilization and small molecularization on the compound liquid to obtain the hyaluronic acid Chinese wolfberry small molecule stock solution. According to the invention, cold sterilization and micromolecularization are achieved, the absorptivity of sodium hyaluronate and Chinese wolfberry fruit nutrients is improved, the taste of the hyaluronic acid Chinese wolfberry fruit micromolecule stock solution is ensured, and nutrient components in the raw materials are prevented from being destroyed.

Description

Technical Field

[0001] This invention belongs to the field of beverage manufacturing technology, specifically relating to a production equipment for hyaluronic acid-goji berry small molecule stock solution based on electron irradiation. Background Technology

[0002] Goji berries, a traditional food and medicine, are rich in various active nutrients such as goji polysaccharides, carotenoids, and betaine. They possess health benefits including antioxidant properties, liver and kidney tonification, blood and essence nourishment, vision improvement, and blood enrichment. Regular consumption can enhance the skin's ability to absorb oxygen. Beverages made from goji berries have become an important category in the health consumer market. However, in current industrial production, to achieve commercial sterility standards and extend shelf life, heat treatment processes such as high-temperature instantaneous sterilization or pasteurization are usually required. These high-temperature processes irreversibly destroy the heat-sensitive active ingredients in goji berries. For example, some goji polysaccharides degrade, vitamins become inactive, and carotenoids undergo isomerization and oxidation, resulting in a significant reduction in the nutritional value of the final product, contradicting its market positioning as a "health beverage."

[0003] Sodium hyaluronate (hyaluronic acid), approved as a food additive in 2015, is a dextranuronic acid, a natural polysaccharide widely found in human connective tissue, skin, eyes, and synovial fluid. It possesses excellent moisturizing, anti-aging, repairing, and lubricating properties. However, the large molecular size of sodium hyaluronate (hyaluronic acid) leads to decreased absorbability, and its strong water-holding capacity and viscosity significantly increase the viscosity of liquid beverages when added, resulting in a thick, unpleasant taste and low consumer acceptance.

[0004] Combining goji berries and sodium hyaluronate (hyaluronic acid) allows the effects of both to work simultaneously on the human body, resulting in good results. However, both have their own processing problems. Therefore, this paper proposes a production equipment for small molecule hyaluronic acid goji berry extract based on electron irradiation, which can overcome the problems of active ingredient destruction, low absorption, and poor taste while combining the two. Summary of the Invention

[0005] In view of the shortcomings of the existing technology, the purpose of this invention is to provide a production equipment for hyaluronic acid-goji berry small molecule stock solution based on electron irradiation.

[0006] To achieve the above-mentioned technical objectives, the technical solution adopted by the present invention is as follows: A device for producing hyaluronic acid-goji berry small molecule stock solution based on electron irradiation, comprising, A high-speed shear emulsifier is used to crush, homogenize, and emulsify soaked goji berries to obtain goji berry liquid; The multi-stage filtration structure is used to filter wolfberry juice in multiple stages to obtain small-molecule wolfberry raw juice; A compounding machine is used to stir and compound small-molecule grade wolfberry extract and sodium hyaluronate solution to obtain a compound solution; and An irradiation generator is used to cold sterilize and reduce the molecular size of the compound solution to obtain hyaluronic acid-goji berry small molecule stock solution.

[0007] This invention uses a high-speed shear emulsifier to crush, homogenize, and emulsify soaked goji berries. Soaking goji berries allows some of their nutrients to dissolve in water, and crushing, homogenizing, and emulsifying releases these nutrients. The multi-stage filtration structure can remove useless impurities from the goji berry liquid while retaining the useful components, thus obtaining small-molecule goji berry puree. The compounding machine is mainly used to stir and compound small molecule grade wolfberry extract and sodium hyaluronate solution. The sodium hyaluronate solution is obtained by dissolving sodium hyaluronate in water. When compounding, sodium hyaluronate solution is added to small molecule grade wolfberry extract at a ratio of 2 to 5‰. To avoid the loss of nutrients in goji berries due to high-temperature sterilization, irradiation was used for cold sterilization and molecular reduction. Cold sterilization avoids the loss of nutrients caused by high-temperature sterilization. The energy of irradiation can homogenize the chemical bonds of large molecules of sodium hyaluronate and goji berry nutrients, thereby degrading large molecules and molecular clusters. After the large molecules are converted into small molecules, the absorption rate of sodium hyaluronate and goji berry nutrients will be greatly improved. In addition, the viscosity of sodium hyaluronate will be reduced, improving the taste when drinking.

[0008] As a preferred technical solution of the present invention, the multi-stage filtration structure includes a pre-filtration structure, a middle filtration structure, and a final filtration structure.

[0009] In this invention, a multi-stage filtration system consisting of primary filtration, secondary filtration, and final filtration is used to achieve layer-by-layer sieving of the wolfberry liquid, effectively removing unwanted substances such as wolfberry seed fragments, coarse fiber, insoluble plant tissue, colloidal particles that may cause precipitation, colloids that cause turbidity, and insoluble macromolecular polymers.

[0010] In some optional examples, the primary filtration structure uses a 200-300 mesh filter to remove physical impurities in the goji berry liquid, such as goji berry seed fragments, coarse fiber, insoluble plant tissue, and colloidal particles that may cause precipitation, thereby obtaining a goji berry liquid with a uniform texture and smooth taste. If the above-mentioned physical impurities are not removed, the goji berry beverage will have a noticeable grainy texture and will experience precipitation and stratification during storage.

[0011] In some optional examples, the core component of the medium-filtration structure is a ceramic membrane filter. The ceramic membrane in the ceramic membrane filter has a filtration precision of 90-110 nanometers. This filtration precision allows the active substances that need to be retained to pass through, such as betaine, carotenoids, vitamins, amino acids, and sugars, while retaining microorganisms such as bacteria and yeast, micron-sized and submicron-sized plant particles, as well as colloids and insoluble macromolecular polymers that cause turbidity in the liquid. This significantly reduces the bioburden of the wolfberry juice and produces a highly clear and transparent filtrate.

[0012] In some optional examples, the core component of the final filtration structure is an ultrafiltration membrane filter. The ultrafiltration membrane in the ultrafiltration membrane filter has a filtration precision of 2900-3100 Daltons, which can achieve precise separation at the molecular weight level. It effectively retains large molecules with molecular weights above the filtration precision, thereby obtaining wolfberry extract rich in small molecule active ingredients (such as betaine, vitamins, carotenoids, amino acids, and sugars). This step not only removes large molecule impurities that may affect the stability and taste of the product, avoiding precipitation and turbidity during storage, but also ensures that the effective ingredients in the final product are in a small molecule state, making them easier for the human body to absorb.

[0013] As a preferred technical solution of the present invention, the irradiation generator is selected from any one of a linear electron accelerator, an X-ray irradiation device, and a cobalt-60 irradiation device.

[0014] In this invention, a linear electron accelerator uses a high-frequency electromagnetic field to accelerate electrons to extremely high speeds in a straight vacuum tube, obtaining very high energy. These high-energy electrons are directly extracted to form an electron beam that bombards the macromolecules of sodium hyaluronate and goji berry nutrients, causing them to undergo physical and chemical changes. Specifically, the excitation and ionization processes cause the molecules to be in a highly unstable state, leading to homolytic cleavage of chemical bonds, thereby achieving the effect of degrading macromolecules and molecular clusters. After the macromolecules are converted into small molecules, the absorption rates of sodium hyaluronate and goji berry nutrients will be greatly improved. In addition, the viscosity of sodium hyaluronate will be reduced, improving the taste when drinking. X-ray irradiation devices generate electrons by heating a cathode, and then accelerate these electrons under a high-voltage electric field to bombard a metal target (usually tungsten, molybdenum, etc.). When high-energy electrons bombard target atoms, bremsstrahlung occurs, producing X-rays, which have stronger penetrating power than electron beams of the same energy level. In some cases, they can be selected as needed. Cobalt-60 irradiation devices utilize the decay of the radioactive isotope cobalt-60. The cobalt-60 nucleus is unstable and will spontaneously decay into stable nickel-60, releasing two gamma photons with energies of 1.17 MeV and 1.33 MeV respectively. Gamma photons have high energy, are uncharged, and have extremely strong penetrating power. They can be selected as needed in some situations.

[0015] As a preferred technical solution of the present invention The beneficial effects of this invention are as follows: While achieving cold sterilization and small molecule reduction, it improves the absorption rate of sodium hyaluronate and goji berry nutrients, ensures the taste of the hyaluronic acid goji berry small molecule stock solution, and avoids the destruction of nutrients in the raw materials. Specifically, the soaked goji berries are crushed, homogenized, and emulsified by a high-speed shear emulsifier to enhance the release of nutrients. Then, the solution is initially filtered through a filter screen, then filtered through a ceramic filter membrane, and finally filtered through an ultrafiltration membrane to extract the required small molecule nutrients. Cold sterilization and small molecule reduction are achieved through irradiation, which improves the absorption rate of sodium hyaluronate and goji berry nutrients and ensures the taste of the hyaluronic acid goji berry small molecule stock solution. Attached Figure Description

[0016] The present invention can be further illustrated by the non-limiting embodiments given in the accompanying drawings; Figure 1 This is a schematic diagram of the filter structure in an embodiment of the present invention; Figure 2 This is a schematic diagram of the final filter structure in an embodiment of the present invention; The symbols for the main components are explained below: 101. Ceramic membrane raw material tank; 102. First bag filter; 103. First feed pump; 104. Ceramic membrane filter; 105. Backwash pump; 106. Backwash tank; 201. Ultrafiltration membrane feed tank; 202. Second feed pump; 203. Second bag filter; 204. Ultrafiltration membrane filter; 205. Ultrafiltration product tank. Detailed Implementation

[0017] The technical solutions of the present invention will be described in detail below with reference to specific embodiments and accompanying drawings. The embodiments described herein are specific implementations of the present invention, used to illustrate the concept of the present invention; these descriptions are explanatory and exemplary, and should not be construed as limiting the implementation methods or the scope of protection of the present invention. In addition to the embodiments described herein, those skilled in the art can employ other obvious technical solutions based on the content disclosed in the claims and specification of this application. These technical solutions include those that make any obvious substitutions and modifications to the embodiments described herein. Example

[0018] like Figure 1 and2 As shown, this embodiment provides a device for producing hyaluronic acid-goji berry small molecule stock solution based on electron irradiation, including... A high-speed shear emulsifier is used to crush, homogenize, and emulsify soaked goji berries to obtain goji berry liquid; Multi-stage filtration structure, including pre-filtration, intermediate filtration and final filtration; The primary filtration structure uses a 200-300 mesh filter screen. The intermediate filtration structure includes a ceramic membrane raw material tank 101, a first feed pump 103, a first bag filter 102, and a ceramic membrane filter 104. The ceramic membrane raw material tank 101 stores the initial filtrate after filtration by the primary filtration structure. The first feed pump 103 is connected to the outlet end of the ceramic membrane raw material tank 101 and the inlet end of the first bag filter 102. The outlet end of the first bag filter 102 is connected to the inlet end of the ceramic membrane filter 104. The permeate outlet end of the ceramic membrane filter 104 is connected to the input side of the final filtration structure. The concentrate outlet end of the ceramic membrane filter 104 is connected to the ceramic membrane raw material tank 101. The ceramic membrane selected for the ceramic membrane filter 104 has a filtration accuracy of 100 nanometers. The final filtration structure includes an ultrafiltration membrane feed tank 201, a second feed pump 202, a second bag filter 203, an ultrafiltration membrane filter 204, and an ultrafiltration product tank 205. The second feed pump 202 is connected to the outlet end of the ultrafiltration membrane feed tank 201 and the inlet end of the second bag filter 203. The inlet end of the ultrafiltration membrane filter 204 is connected to the outlet end of the second bag filter 203. The permeate outlet of the ultrafiltration membrane filter 204 is connected to the ultrafiltration product tank 205. The retentate outlet of the ultrafiltration membrane filter 204 is connected to the ultrafiltration membrane feed tank 201. The ultrafiltration membrane filtration accuracy of the ultrafiltration membrane filter 204 is 3000 Daltons. A compounding machine is used to stir and compound small-molecule grade wolfberry extract and sodium hyaluronate solution to obtain a compound solution; and A linear electron accelerator is used for cold sterilization and molecularization of the compound solution to obtain hyaluronic acid and wolfberry small molecule stock solution; The flow direction of the liquid is controlled by valves.

[0019] In this embodiment, a high-speed shear emulsifier is used to crush, homogenize and emulsify the soaked goji berries. After soaking, some of the nutrients in the goji berries can dissolve in the water. Through crushing, homogenizing and emulsifying, the nutrients in the soaked goji berries can be released. The multi-stage filtration structure can remove useless impurities from the goji berry liquid while retaining useful components, thus obtaining small molecule-level goji berry stock solution. The ceramic membrane raw material tank 101 stores the wolfberry liquid after filtration by the filter screen. The first feed pump 103 pumps the wolfberry liquid to the first bag filter 102 for further filtration. The filtered wolfberry liquid flows to the ceramic membrane filter 104. The ceramic membrane filter 104 has two outlets: one outlet is the leachate outlet, which is used to discharge the filtered and permeated liquid, and the other outlet is the concentrate outlet, which is used to discharge the retained and concentrated liquid. The filtered and permeated liquid enters the ultrafiltration membrane feed tank 201 for storage, while the liquid that has been retained and concentrated is returned to the ceramic membrane feed tank 101 to await the next cycle. The liquid in the ultrafiltration membrane feed tank 201 is pumped to the second bag filter 203 by the second feed pump 202 for filtration. The filtered liquid is sent to the ultrafiltration membrane filter 204. The ultrafiltration membrane filter 204 has two outlets: one outlet is the permeate outlet, which is used to discharge the filtered permeate liquid, and the other outlet is the retentate outlet, which is used to connect with the ultrafiltration membrane feed tank 201 and output the retentate liquid. The compounding machine is mainly used to stir and compound small molecule grade wolfberry extract and sodium hyaluronate solution. The sodium hyaluronate solution is obtained by dissolving sodium hyaluronate in water. When compounding, sodium hyaluronate solution is added to small molecule grade wolfberry extract at a ratio of 2 to 5‰. The linear electron accelerator uses a high-frequency electromagnetic field in a straight vacuum tube to accelerate electrons to extremely high speeds and obtain high energy. These high-energy electrons are directly extracted to form an electron beam that bombards the macromolecules of sodium hyaluronate and goji berry nutrients, causing physical and chemical changes. Specifically, the excitation and ionization processes put the molecules in a highly unstable state, leading to homolytic cleavage of chemical bonds, thereby degrading macromolecules and molecular clusters. After the macromolecules are converted into smaller molecules, the absorption rates of sodium hyaluronate and goji berry nutrients are greatly improved. In addition, the viscosity of sodium hyaluronate is reduced, improving the taste when drinking. During sterilization, the cumulative dose of irradiation by the linear electron accelerator is guaranteed to reach 8-10 kGy. During the reduction of molecules, the pulse high voltage of the linear electron accelerator is adjusted to 150 kV and the operating frequency of the excitation source is between 170-200 Hz. Example

[0020] like Figure 1As shown, this embodiment provides a hyaluronic acid-goji berry small molecule stock solution production device based on electron irradiation. The difference from Embodiment 1 is that a backwashing structure for the ceramic membrane filter 104 is designed, which includes a backwashing pump 105 and a backwashing tank 106. The backwashing tank 106 stores backwashing liquid. One end of the backwashing pump 105 is connected to the backwashing tank 106, and the other end is connected to the permeate outlet of the ceramic membrane filter 104. The pipeline between the concentrated liquid outlet of the ceramic membrane filter 104 and the ceramic membrane raw material tank 101 is connected to a backwashing drain pipe. The flow direction of the liquid in each pipeline is controlled by valves.

[0021] In this embodiment, the backwash pump 105 pumps the backwash liquid in the backwash tank 106 to the leachate outlet of the ceramic membrane filter 104, so that the backwash liquid impacts the impurities trapped on the ceramic filter membrane and carries these impurities away from the ceramic filter membrane, so that the ceramic filter membrane can restore its filtration capacity. The impurities mixed with the backwash liquid are discharged through the backwash drain pipe, and the liquid flow direction is controlled by the valve.

[0022] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the present invention. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in the present invention should still be covered by the claims of the present invention.

Claims

1. A production equipment for hyaluronic acid-goji berry small molecule stock solution based on electron irradiation, characterized in that: include, A high-speed shear emulsifier is used to crush, homogenize, and emulsify soaked goji berries to obtain goji berry liquid; The multi-stage filtration structure is used to filter wolfberry juice in multiple stages to obtain small-molecule wolfberry raw juice; The compounding machine is used to stir and compound small-molecule grade wolfberry extract and sodium hyaluronate solution to obtain a compound solution; as well as An irradiation generator is used to cold sterilize and reduce the molecular size of the compound solution to obtain hyaluronic acid-goji berry small molecule stock solution.

2. The hyaluronic acid-goji berry small molecule stock solution production equipment based on electron irradiation according to claim 1, characterized in that: The multi-stage filtration structure includes a pre-filtration structure, a middle filtration structure, and a final filtration structure.

3. The hyaluronic acid-goji berry small molecule stock solution production equipment based on electron irradiation according to claim 2, characterized in that: The primary filtration structure uses a 200-300 mesh filter.

4. The equipment for producing hyaluronic acid-goji berry small molecule stock solution based on electron irradiation according to claim 2, characterized in that: The intermediate filter structure includes a ceramic membrane raw material tank (101), a first feed pump (103), a first bag filter (102), and a ceramic membrane filter (104). The ceramic membrane raw material tank (101) stores the pre-filtrate after filtration by the pre-filtration structure; The first feed pump (103) is connected to the outlet end of the ceramic membrane raw material tank (101) and the inlet end of the first bag filter (102). The outlet end of the first bag filter (102) is connected to the inlet end of the ceramic membrane filter (104). The leachate outlet end of the ceramic membrane filter (104) is connected to the input side of the final filter structure. The concentrate outlet end of the ceramic membrane filter (104) is connected to the ceramic membrane raw material tank (101).

5. The equipment for producing hyaluronic acid-goji berry small molecule stock solution based on electron irradiation according to claim 4, characterized in that: It also includes a backwash pump (105) and a backwash tank (106), the backwash tank (106) storing backwash liquid, one end of the backwash pump (105) being connected to the backwash tank (106) and the other end being connected to the leachate outlet of the ceramic membrane filter (104), and a backwash drain pipe being connected to the pipeline between the concentrate outlet of the ceramic membrane filter (104) and the ceramic membrane raw material tank (101).

6. The equipment for producing hyaluronic acid-goji berry small molecule stock solution based on electron irradiation according to claim 4 or 5, characterized in that: The intermediate filter structure also includes a valve for controlling the flow direction.

7. The hyaluronic acid-goji berry small molecule stock solution production equipment based on electron irradiation according to claim 4, characterized in that: The ceramic membrane filter (104) uses a ceramic filter membrane with a filtration accuracy of 90-110 nanometers.

8. The equipment for producing hyaluronic acid-goji berry small molecule stock solution based on electron irradiation according to claim 2, characterized in that: The final filtration structure includes an ultrafiltration membrane feed tank (201), a second feed pump (202), a second bag filter (203), an ultrafiltration membrane filter (204), and an ultrafiltration product tank (205). The second feed pump (202) is connected to the outlet end of the ultrafiltration membrane raw material tank (201) and the inlet end of the second bag filter (203); The inlet end of the ultrafiltration membrane filter (204) is connected to the outlet end of the second bag filter (203), the permeate outlet of the ultrafiltration membrane filter (204) is connected to the ultrafiltration product tank (205), and the retentate outlet of the ultrafiltration membrane filter (204) is connected to the ultrafiltration membrane raw material tank (201).

9. The equipment for producing hyaluronic acid-goji berry small molecule stock solution based on electron irradiation according to claim 8, characterized in that: The ultrafiltration membrane filter (204) has an ultrafiltration accuracy of 2900-3100 Daltons.

10. The equipment for producing hyaluronic acid-goji berry small molecule stock solution based on electron irradiation according to claim 1, characterized in that: The irradiation generator can be any one of a linear electron accelerator, an X-ray irradiation device, or a cobalt-60 irradiation device.

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