Sanhuang heart-purging decoction fiber fabric as well as preparation method and application thereof

Abstract

The invention relates to a Sanhuang heart-fire-removing decoction fiber fabric and a preparation method and application thereof, the Sanhuang heart-fire-removing decoction fiber fabric is of a three-layer structure, and the Sanhuang heart-fire-removing decoction fiber fabric is formed by sequentially overlapping an inner baicalin fiber layer, a middle berberine fiber layer and an outer emodin fiber layer and carrying out hot press molding. Baicalin is loaded in the inner layer baicalin fiber layer, berberine is loaded in the middle layer berberine fiber layer, and emodin is loaded in the outer layer emodin fiber layer. The three active components of baicalin, berberine and emodin are respectively loaded on independent fiber carriers, so that the problems of solubility conflict and interaction precipitation caused by co-loading of the three components are fundamentally avoided, the drug loading capacity is effectively improved, the drug loading efficiency is remarkably improved, and meanwhile, the good drug release stability is ensured; and by combining with a hot press molding process after layered superposition, the interlayer binding force of the multi-layer fiber structure is enhanced, so that the fabric forms a complete and compact whole, and the structural carrier is relatively stable.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of traditional Chinese medicine functional fibers, in particular to a Sanhuang Xiexin Decoction fiber fabric, a preparation method and application thereof. BACKGROUND

[0002] Traditional Chinese medicine functional fibers are functional materials that combine active ingredients of traditional Chinese medicine and fiber materials, which can endow fibers with antibacterial, anti-inflammatory and other properties, and have great application potential in medical dressings, protective textiles and other fields.

[0003] Sanhuang Xiexin Decoction, as a classic traditional Chinese medicine prescription derived from Zhang Zhongjing's Golden Chamber, is composed of Huangqin, Dahuang and Huanglian. Its core active ingredients, Huangqin glycoside, emodin and berberine, can synergistically exert the effects of clearing heat, detoxifying and antibacterial, and have important application potential in topical antibacterial, wound care and protective textiles. Sanhuang Xiexin Decoction is composed of three traditional Chinese medicines, Huangqin, Dahuang and Huanglian, and has the effects of clearing heat, detoxifying and antibacterial.

[0004] To apply the active ingredients of Sanhuang Xiexin Decoction to functional fiber fabrics, existing technologies have attempted to co-load the three ingredients in a single fiber carrier. However, due to the significant differences in solubility, Huangqin glycoside is easily soluble in dimethylformamide and pyridine, slightly soluble in hot acetic acid, difficult to dissolve in methanol, ethanol and acetone, and almost insoluble in water, diethyl ether, benzene and chloroform; berberine has a high solubility in hot water, but is difficult to dissolve in common organic solvents such as propyl alcohol, chloroform or benzene; emodin is almost insoluble in water, but soluble in ethanol and alkaline solution, making it difficult to choose a common solvent and a polymer matrix; chemical reactions between the ingredients easily occur to produce precipitates, reducing the drug loading concentration; meanwhile, the self-precipitation formed between the three ingredients also affects the mechanical properties and drug release performance of the carrier. In other words, Huangqin glycoside is easily soluble in N,N-dimethylformamide, berberine is easily soluble in hot water, and emodin is difficult to dissolve in water and only soluble in ethanol and alkaline solution, making it difficult to select a common solvent and a polymer matrix for the three ingredients; and chemical reactions between the ingredients easily occur to produce precipitates, not only reducing the drug loading concentration, but also damaging the microstructure and mechanical properties of the fiber carrier, resulting in poor drug release stability and short antibacterial duration.

[0005] In summary, the active ingredients of Sanhuang Xiexin Decoction, Huangqin glycoside, emodin and berberine, have synergistic antibacterial effects, but due to the large differences in solubility and the easy interaction and precipitation between them, co-loading in a single fiber carrier affects the drug loading efficiency, drug release stability and mechanical properties of the fiber. Existing methods such as blending spinning are difficult to solve these problems, which restricts the application of Sanhuang Xiexin Decoction in functional fibers.

[0006] At the same time, functional fabrics need to have both structural stability and practical performance. The fiber structure formed by existing preparation methods such as blending spinning is loose, and the interlayer bonding force is weak, requiring additional processes to improve the structural integrity. However, traditional processes are difficult to achieve stable construction of multi-layer fiber structure while solving the problem of co-loading of ingredients, which restricts the research and application of Sanhuang Xiexin Decoction functional fiber fabric. SUMMARY

[0007] Therefore, in order to solve the problems of component interaction, solubility mismatch, release control difficulty and fiber performance damage when co-loading baicalin, emodin and berberine in Sanhuang Xiexin Decoction, the application provides a Sanhuang Xiexin Decoction fiber fabric with high drug loading capacity, high drug loading efficiency, good drug release stability and relatively stable structure carrier, and a preparation method and application thereof, so as to realize stable loading and synergistic release of the three components In a first aspect, the application provides a Sanhuang Xiexin Decoction fiber fabric, characterized in that the Sanhuang Xiexin Decoction fiber fabric has a three-layer structure, and is formed by sequentially stacking an inner baicalin fiber layer, a middle berberine fiber layer and an outer emodin fiber layer and hot pressing.

[0008] In one embodiment, the total loading amount of the three traditional Chinese medicine active ingredients of emodin, berberine and baicalin in the Sanhuang Xiexin Decoction fiber fabric is 5-20 wt%, and the mass ratio of emodin, berberine and baicalin is "1.5-3.0":1:"0.5-2.0".

[0009] In one embodiment, the inner baicalin fiber layer is formed by using polyurethane as a high molecular base material, loading baicalin and adding 5-15 wt% siloxane hydrophobic modifier, and a mixed solvent of N,N-dimethylformamide and tetrahydrofuran is used in the preparation of the fiber layer. In one embodiment, the middle berberine fiber layer is formed by using a polyamide, chitosan or silk fibroin polymer as a base material and loading berberine, and a mixed solvent of formic acid and acetic acid is used in the preparation of the fiber layer. In one embodiment, the outer emodin fiber layer is formed by using a polylactic acid or polyacrylonitrile polymer as a base material and loading emodin, and one or more of trichloromethane, acetone and N,N-dimethylformamide is used as a solvent in the preparation of the fiber layer.

[0010] In one embodiment, the inner baicalin fiber layer is formed by a spinning process through a baicalin spinning solution, the baicalin spinning solution uses polyurethane as a high molecular base material, a mixed solvent of N,N-dimethylformamide and tetrahydrofuran as a solvent, a volume ratio of 3:1~1:1, a mass concentration of the high molecular solution of 5-30%, a mass concentration of baicalin of 5-20%, and 5-15 wt% siloxane hydrophobic modifier is added, and the humidity is controlled to be 30-90% during the spinning process. In one of the embodiments, the middle berberine fiber layer is formed by a spinning process via a berberine spinning solution, the berberine spinning solution adopts a polyamide, chitosan, silk fibroin polymer as a high polymer base material for electrostatic spinning, a formic acid and acetic acid mixed solvent as a solvent, a volume ratio of 1:1, a mass concentration of the high polymer solution of 8-20%, a mass concentration of berberine of 5-20%, and a humidity control of the spinning process of 30-40%. In one of the embodiments, the outer emodin fiber layer is formed by a spinning process via an emodin spinning solution, the emodin spinning solution adopts a polylactic acid or polyacrylonitrile polymer as a high polymer base material for electrostatic spinning, one or more of trichloromethane, acetone, and N,N-dimethylformamide as a solvent, a mass concentration of the high polymer solution of 5-30%, a mass concentration of emodin of 5-20%, and a humidity control of the spinning process of 30-40%.

[0011] In one of the embodiments, the fabric area density is 15-35 g / m2, and the thickness is 100-400 μm.

[0012] In one of the embodiments, in the Sanhuang Xiexin Decoction fiber fabric, the single fiber diameter is 50 nm-2 μm; the water contact angle difference between the hydrophilic outer emodin fiber layer and the hydrophobic inner baicalin fiber layer is ≥45°, preferably, the water contact angle difference between the hydrophilic outer emodin fiber layer and the hydrophobic inner baicalin fiber layer is ≥50°.

[0013] In one of the embodiments, the fiber pore size of the outer emodin fiber layer is 1.5 microns to 3.3 microns, the fiber pore size of the middle berberine fiber layer is 2.9 microns to 5.3 microns, the fiber pore size of the inner baicalin fiber layer is 5.0 microns to 9.4 microns, and the water contact angle difference between the hydrophilic outer emodin fiber layer and the hydrophobic inner baicalin fiber layer is ≥45°, preferably, the water contact angle difference between the hydrophilic outer emodin fiber layer and the hydrophobic inner baicalin fiber layer is ≥50°.

[0014] In one of the embodiments, in the baicalin spinning solution, the mass concentration of baicalin is 10%; and / or, in the berberine spinning solution, the mass concentration of berberine is 10%; and / or, in the emodin spinning solution, the mass concentration of emodin is 10%; and / or, the mass ratio of emodin, berberine, and baicalin is 1:1:1.

[0015] In a second aspect, the application provides a preparation method of the Sanhuang Xiexin Decoction fiber fabric as described in any one of the above embodiments, characterized in that the method comprises the following steps: respectively preparing emodin spinning solution, baicalin spinning solution, and berberine spinning solution; The three kinds of spinning solutions are spun through layered electrospinning technology in the order of "baicalin fiber layer-berberine fiber layer-emodin fiber layer", and are directly stacked on the receiving device to form a multi-layer fiber structure corresponding to the baicalin fiber layer, the berberine fiber layer and the emodin fiber layer. The multi-layer fiber structure is formed into the Sanhuang Xiexin Decoction fiber fabric through hot pressing.

[0016] In one embodiment, in the emodin spinning solution, polylactic acid or polyacrylonitrile polymer is used as the polymer base material for electrospinning, and one or more of chloroform, acetone and N,N-dimethylformamide is used as the solvent; the mass concentration of the polymer solution is 5-30%, and the mass concentration of emodin is 5-20%; and the environmental humidity during spinning is controlled to be 30-40%. In one embodiment, in the baicalin spinning solution, polyurethane is used as the polymer base material, and a mixed solvent of N,N-dimethylformamide and tetrahydrofuran is used as the solvent, with a volume ratio of 3:1 to 1:1; the mass concentration of the polymer solution is 5-30%, and the mass concentration of baicalin is 5-20%; and 5-15 wt% of a siloxane hydrophobic modifier is added to the spinning solution; and the environmental humidity during spinning is controlled to be 30-90%. In one embodiment, in the berberine spinning solution, polyamide, chitosan or silk fibroin polymer is used as the polymer base material for electrospinning, and a mixed solvent of formic acid and acetic acid with a volume ratio of 1:1 is used as the solvent; the mass concentration of the polymer solution is 8-20%, and the mass concentration of berberine is 5-20%; and the environmental humidity during spinning is controlled to be 30-40%. In one embodiment, in the layered electrospinning, the voltage is controlled to be 15-35 kV, the receiving distance is 12-20 cm, the liquid feeding rate is 0.3-2 mL / h, and the environmental temperature is maintained at 25°C. In one embodiment, in the hot pressing, the hot pressing is performed at 40-100°C and 0.1-0.3 MPa.

[0017] In a third aspect, the application also provides the use of the Sanhuang Xiexin Decoction fiber fabric prepared according to any one of the above embodiments or prepared by the preparation method of the Sanhuang Xiexin Decoction fiber fabric according to any one of the above embodiments in the field of medical dressings and the field of protective textiles.

[0018] The three-yellow heart soup fiber fabric has a layered structure design of "inner layer of baicalin fiber layer-middle layer of berberine fiber layer-outer layer of emodin fiber layer", and the baicalin, berberine and emodin are loaded on the single fiber carrier respectively, so that the solubility conflict and interaction precipitation problem of the three components caused by co-loading are fundamentally avoided, the drug loading capacity is effectively improved, the drug loading efficiency is significantly improved, and the drug release stability is ensured to be good; and then, the heat pressing forming process after the layering and stacking is combined, the interlayer bonding force of the multi-layer fiber structure is enhanced, the fabric forms a complete and compact whole, and the structure carrier is relatively stable, which lays a foundation for further optimizing the fabric function and promoting the application in the related field.

[0019] In the preferred embodiments of the present application, the following advantages are also provided: 1. The "single fiber loading single component" strategy is adopted, so that the interaction and precipitation problem of the core components such as baicalin, emodin and berberine in the three-yellow heart soup caused by the solubility difference in the fiber carrier is fundamentally avoided, the release stability, drug loading efficiency and release duration of each component are significantly improved, and the release of the fiber fabric can be maintained for 10 times of washing during the washing process; 2. The high molecular substrate and solvent are selected according to the characteristics of each component, the spinnability of the spinning solution is optimized, the fiber diameter is uniform (50 nm-2 μm), the spinning stability is improved, and the mechanical strength of the fiber is improved.

[0020] 3. The three components are released cooperatively by layering spinning, and the fabric has the functions of long-acting sterilization, moisture absorption, sweat removal, waterproofness and air permeability by combining the hydrophilic and hydrophobic properties and pore structure adjustment of different high molecular fiber materials. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 The electron microscope pictures of the three fiber layers in Embodiment 1 of the present application Figure 2 The fiber mechanical property comparison chart of each embodiment of the present application Figure 3 The total cumulative drug release amount comparison chart in each embodiment of the present application. DETAILED DESCRIPTION

[0022] For the purpose of facilitating the understanding of the present application, in order to make the above-mentioned objects, features and advantages of the present application more apparent and comprehensible, the specific embodiments of the present application will be described in detail below with reference to the accompanying drawings. In the following description, a large number of specific details are set forth in order to provide a sufficient understanding of the present application, and the preferred embodiments of the present application are given in the accompanying drawings. However, the present application can be implemented in many different forms, and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive. The present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without departing from the scope of the present application, so the present application is not limited to the specific embodiments disclosed below. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as understood by those skilled in the art to which the present application belongs. The terms used herein are only for the purpose of describing the specific embodiments and are not intended to limit the present application. The term "and / or" as used herein includes any and all combinations of one or more of the related listed items.

[0023] In a first aspect, the present application provides a Sanhuang Xiexin Decoction fiber fabric, which is a three-layer structure formed by sequentially stacking and hot-pressing an inner layer of baicalin fiber layer, a middle layer of berberine fiber layer, and an outer layer of rhein fiber layer. The inner layer of baicalin fiber layer contains baicalin, the middle layer of berberine fiber layer contains berberine, and the outer layer of rhein fiber layer contains rhein. The baicalin, berberine, and rhein are loaded in separate fiber layers in the inner layer, middle layer, and outer layer, respectively, and are hot-pressed, which fundamentally avoids the solubility conflict and interaction precipitation problem of the three components due to co-loading, and enhances the interlayer bonding force of the multilayer fiber layer, making the fabric structure carrier more stable, laying a foundation for subsequent improvement of drug loading and release performance and fabric practical performance, and solving the core problem of component interaction and loose structure under the existing co-loading mode.

[0024] The above-mentioned Sanhuang Xiexin Decoction fiber fabric, through the layered structure design of "inner layer of baicalin fiber layer-middle layer of berberine fiber layer-outer layer of rhein fiber layer", loads the three active components of baicalin, berberine, and rhein on separate fiber carriers, which fundamentally avoids the solubility conflict and interaction precipitation problem of the three components due to co-loading, effectively improves the drug loading capacity, significantly improves the drug loading efficiency, and ensures good drug release stability; combined with the hot-pressing process after layering and stacking, the interlayer bonding force of the multilayer fiber structure is enhanced, the fabric forms a complete and compact whole, and the structure carrier is relatively stable, laying a foundation for further optimization of fabric function and promoting its application in related fields.

[0025] In one of the embodiments, the total loading amount of emodin, berberine and baicalin in the Sanhuang Xiexin Decoction fiber fabric is 5-20 wt%, and the mass ratio of emodin, berberine and baicalin is “1.5-3.0”:1: “0.5-2.0”. In this way, the loading amount and ratio match the synergistic antibacterial properties of the three components, which not only ensures sufficient drug content to achieve long-acting antibacterial effect, but also avoids the weakening of efficacy due to unbalanced component ratio; at the same time, compared with blended spinning, the cumulative drug release amount under this ratio significantly improves the stability, further optimizes the drug release performance, and meets the needs of compound delivery.

[0026] In one of the embodiments, the inner baicalin fiber layer is formed by loading baicalin and adding 5-15 wt% siloxane hydrophobic modifier based on polyurethane as the high molecular base material, and the fiber layer is prepared using a mixed solvent of N,N-dimethylformamide and tetrahydrofuran; for example, the inner baicalin fiber layer is formed by a spinning process through a baicalin spinning solution, the baicalin spinning solution uses polyurethane as the high molecular base material, the solvent is a mixed solvent of N,N-dimethylformamide and tetrahydrofuran with a volume ratio of 3:1~1:1, the mass concentration of the high molecular solution is 5-30%, the mass concentration of baicalin is 5-20%, and 5-15 wt% siloxane hydrophobic modifier is added, and the humidity control during the spinning process is 30-90%; in this way, it is ensured that baicalin is fully dissolved and the spinning process is stable, and the inner baicalin fiber layer is prepared based on polyurethane as the base material, N,N-dimethylformamide and tetrahydrofuran mixed solvent and adding siloxane hydrophobic modifier, which matches the solubility of baicalin and gives the inner layer hydrophobic properties; and it is also conducive to improving the antibacterial, antiviral and antipathogen properties of baicalin given to the fiber fabric.

[0027] In one of the embodiments, the middle berberine fiber layer is formed by loading berberine based on polyamide, chitosan or silk fibroin polymer as the base material, and the fiber layer is prepared using a mixed solvent of formic acid and acetic acid; in one of the embodiments, the middle berberine fiber layer is formed by a spinning process through a berberine spinning solution, the berberine spinning solution uses polyamide, chitosan or silk fibroin polymer as the high molecular base material for electrospinning, the solvent is a mixed solvent of formic acid and acetic acid with a volume ratio of 1:1, the mass concentration of the high molecular solution is 8-20%, and the mass concentration of berberine is 5-20%, and the humidity control during the spinning process is 30-40%; in this way, the berberine spinning solution limits the solvent volume ratio to 1:1, the high molecular solution concentration to 8-20%, and the spinning humidity to 30-40%, which ensures uniform loading of berberine and the quality of fiber formation; and it is also conducive to improving the antibacterial and antipathogen properties of berberine given to the fiber fabric.

[0028] In one embodiment, the outer emodin fiber layer is formed by loading emodin on polylactic acid or polyacrylonitrile polymer as a base material, and one or more of chloroform, acetone, and N,N-dimethylformamide is used as a solvent during the preparation of the fiber layer. In one embodiment, the outer emodin fiber layer is formed by a spinning process using an emodin spinning solution, in which polylactic acid or polyacrylonitrile polymer is used as a high molecular base material for electrospinning, and one or more of chloroform, acetone, and N,N-dimethylformamide is used as a solvent, the mass concentration of the high molecular solution is 5-30%, the mass concentration of emodin is 5-20%, and the humidity during the spinning process is controlled to be 30-40%. In this way, the outer emodin fiber layer is prepared using polylactic acid or polyacrylonitrile polymer as a base material and a specific mixed solvent to match the solubility of emodin, and the emodin spinning solution limits the high molecular solution concentration to 5-30% and the spinning humidity to 30-40% to improve the dispersibility and spinning stability of emodin. By setting the mass concentration of emodin to 5-20%, the antibacterial and anti-pathogen properties of the fabric imparted by emodin are improved.

[0029] In this application, due to the process and proportioning of the inner baicalin fiber layer, the middle berberine fiber layer, and the outer emodin fiber layer, the three active ingredients of baicalin, emodin, and berberine achieve synergistic effect through the design of "single fiber loading single component" in the layered co-loading: in terms of antibacterial, the three rely on their respective inhibitory advantages of different types of bacteria and the action characteristics at different stages of bacterial growth, and synergistically expand the antibacterial spectrum and improve the antibacterial efficiency, fully exerting the antibacterial efficacy of the classic Sanhuang Xiexin Decoction; in terms of drug release, the layered structure of the outer emodin fiber layer, the middle berberine fiber layer, and the inner baicalin fiber layer, combined with the hydrophilic and hydrophobic properties and pore size differences of the base materials of each layer, forms a synergistic drug release mode of "initial effect - mid-term maintenance - long-term endurance", avoiding the release disorder during co-loading, and significantly improving the stability of the cumulative drug release; in terms of durability, the specific high molecular base material matched by each fiber layer ensures the stable retention of the components, the addition of silicone hydrophobic modifier and the hot pressing process enhance the stability of the fabric structure, reduce the drug loss during washing, so that the synergistic effect of the three can be maintained for a long time, ensuring that the fabric has long-acting antibacterial, stable drug release, and stable use in complex delivery, surface antibacterial, and other application scenarios.

[0030] In one of the embodiments, the fabric area density is 15-35 g / m2, and the thickness is 100-400 μm. In this way, this range makes the fabric have both light and thin characteristics and structural strength: too high area density and thickness will result in thick and heavy fabric and reduced air permeability, and too low area density and thickness will result in insufficient mechanical properties of the fabric and easy breakage; under this parameter range, the fabric can meet the requirements of light and thin comfort of medical dressings and protective textiles, and can also ensure structural stability, while providing sufficient space for drug loading and avoiding insufficient drug loading due to too thin fabric, balancing the practicality and functional requirements of the fabric.

[0031] In one of the embodiments, the water contact angle difference between the hydrophilic outer layer of emodin fibers and the hydrophobic inner layer of baicalin fibers is ≥45°, and preferably, the water contact angle difference between the hydrophilic outer layer of emodin fibers and the hydrophobic inner layer of baicalin fibers is ≥50°. In this way, the single fiber diameter is limited to 50 nm-2 μm, which ensures that the fibers have a large specific surface area, which is beneficial for drug loading and release; the gradient pore size structure of the outer layer of emodin fibers with a fiber pore size of 1.5-3.3 μm, the middle layer of berberine fibers with a fiber pore size of 2.9-5.3 μm, and the inner layer of baicalin fibers with a fiber pore size of 5.0-9.4 μm, combined with the water contact angle difference of ≥50° between the hydrophilic outer layer and the hydrophobic inner layer, realizes the functions of fabric moisture absorption, sweat wicking, and waterproofing: the outer layer is hydrophilic and has a large pore size, which can quickly absorb body sweat; the inner layer is hydrophobic and has a small pore size, which can prevent external water from penetrating in, while sweat is discharged to the outer layer through the middle layer of gradient pore size for evaporation, solving the problem that traditional fabrics are difficult to balance waterproofing and moisture absorption and sweat wicking; in addition, the gradient pore size and the difference between hydrophilic and hydrophobic can also regulate the drug release rate, further improving the stability of drug release, so that the fabric has the comprehensive performance of long-acting sterilization, waterproofing, air permeability, moisture absorption, and sweat wicking.

[0032] The three-yellow heart soup fiber fabric has a layered structure of "inner layer of baicalin fiber layer-middle layer of berberine fiber layer-outer layer of emodin fiber layer", and baicalin, berberine and emodin are loaded on the single fiber carrier respectively, so that the solubility conflict and interaction and precipitation problem of the three components are fundamentally avoided, the drug loading capacity is effectively improved, the drug loading efficiency is significantly improved, and the drug release stability is ensured; in combination with the hot-pressing forming process after the layering and stacking, the interlayer bonding force of the multi-layer fiber structure is enhanced, the fabric forms a complete and compact whole, and the structure carrier is relatively stable, which lays a foundation for further optimizing the fabric function and promoting the application in the related field. Moreover, the "single fiber loading single component" strategy is adopted, the interaction and precipitation problem of the core components such as baicalin, emodin and berberine in the three-yellow heart soup due to the solubility difference in the fiber carrier is fundamentally avoided, the release stability, drug loading efficiency and release time of each component are significantly improved, and the release of the fiber fabric can be maintained for 10 times of washing. The polymer matrix and solvent are selected according to the characteristics of each component, the spinnability of the spinning solution is optimized, the fiber diameter is uniform (50 nm-2 μm), the spinning stability is improved, and the mechanical strength of the fiber is improved. The three components are released cooperatively by layering spinning, and the fabric has the functions of long-acting sterilization, moisture absorption, sweat removal, waterproofness and air permeability by adjusting the hydrophilic and hydrophobic properties and pore structure of different polymer fiber materials.

[0033] In a second aspect, the application provides a preparation method of the three-yellow heart soup fiber fabric as described in any one of the above embodiments, and the method comprises the following steps: Preparation of emodin spinning solution, baicalin spinning solution and berberine spinning solution respectively; Using the emodin spinning solution, the baicalin spinning solution and the berberine spinning solution as raw materials, the three spinning solutions are stacked in the order of "baicalin fiber layer-berberine fiber layer-emodin fiber layer", and the three spinning solutions are spun by the layered electrospinning technology to form the corresponding multi-layer fiber structure of baicalin fiber layer, berberine fiber layer and emodin fiber layer on the receiving device. The multi-layer fiber structure is formed into the three-yellow heart soup fiber fabric by hot-pressing.

[0034] Thus, by the steps of "preparing spinning solution separately - layering electrospinning superposition - hot pressing", the layered loading and stable molding of the three components are realized: preparing spinning solution separately avoids the premature mixing and interaction of components; layering electrospinning superposition ensures the integrity of each fiber layer structure and the uniformity of components; hot pressing enhances the interlayer bonding force. This method is controllable and can stably prepare a three-layer structure fabric, solving the problems of component interaction, uneven drug loading and loose structure in the existing blending spinning process. At the same time, it provides a feasible solution for large-scale production, ensures the batch stability of the product, and improves the preparation efficiency.

[0035] In one of the embodiments, in the emodin spinning solution, polylactic acid or polyacrylonitrile polymer is used as the electrospinning polymer matrix, and one or more of chloroform, acetone, and N,N-dimethylformamide is used as the solvent; the mass concentration of the polymer solution is 5-30%, and the mass concentration of emodin is 5-20%; the environmental humidity during the spinning process is controlled to be 30-40%; for example, in the baicalin spinning solution, polyurethane is used as the polymer matrix, and a mixed solvent of N,N-dimethylformamide and tetrahydrofuran is used as the solvent, with a volume ratio of 3:1 to 1:1; the mass concentration of the polymer solution is 5-30%, the mass concentration of baicalin is 5-20%, and 5-15 wt% of a siloxane hydrophobic modifier is added to the spinning solution; the environmental humidity during the spinning process is controlled to be 30-90%; for example, in the berberine spinning solution, polyamide, chitosan, or silk fibroin polymer is used as the electrospinning polymer matrix, and a mixed solvent of formic acid and acetic acid with a volume ratio of 1:1 is used as the solvent; the mass concentration of the polymer solution is 8-20%, and the mass concentration of berberine is 5-20%; the environmental humidity during the spinning process is controlled to be 30-40%; for example, in the layered electrospinning, the voltage is controlled to be 15-35 kV, the receiving distance is 12-20 cm, the liquid feeding rate is 0.3-2 mL / h, and the environmental temperature is maintained at 25°C; for example, in the hot-pressing forming, the hot-pressing forming is performed at 40-100°C and 0.1-0.3 MPa. In this way, by using the above spinning solution and preparation process, the baicalin, emodin, and berberine three active ingredients realize the synergistic effect through the layered co-loading design of “single fiber loading single component”: in terms of antibacterial effect, the three ingredients rely on their respective inhibitory advantages for different types of bacteria and the action characteristics at different stages of bacterial growth, and cooperatively expand the antibacterial spectrum and improve the antibacterial efficiency, thereby fully exerting the antibacterial effect of the classic Sanhuang Xiexin Decoction; in terms of drug release, the layered structure of the outer emodin fiber layer, the middle berberine fiber layer, and the inner baicalin fiber layer, combined with the hydrophilic and hydrophobic properties and pore size differences of the layers, forms a synergistic drug release mode of “initial effect - medium-term maintenance - long-term endurance”, avoids the release disorder during co-loading, and significantly improves the stability of the cumulative drug release amount; in terms of long-term performance, the specific polymer matrix matched by each fiber layer ensures the stable retention of the ingredients, the addition of the siloxane hydrophobic modifier and the hot-pressing forming process enhance the stability of the fabric structure, reduce the drug loss during the washing process, and make the synergistic effect of the three ingredients long-term maintained, thereby ensuring that the fabric has long-term antibacterial, stable drug release, and stable use in the application scenarios of compound delivery and body surface antibacterial effect.

[0036] In a third aspect, the application also provides the use of the Sanjiaoxin Decoction fiber fabric as in any of the above embodiments or the Sanjiaoxin Decoction fiber fabric prepared by the preparation method of the Sanjiaoxin Decoction fiber fabric as in any of the above embodiments in the field of medical dressings and the field of protective textiles.

[0037] The Sanjiaoxin Decoction fiber fabric described above, through the layered structure design of "inner layer of scutellarein fiber layer - middle layer of berberine fiber layer - outer layer of emodin fiber layer", loads the three active ingredients of scutellarein, berberine and emodin on separate fiber carriers respectively, fundamentally avoids the solubility conflict and interaction precipitation problem of the three components due to co-loading, effectively improves the drug loading capacity, significantly improves the drug loading efficiency, and at the same time ensures good drug release stability; combined with the hot-pressing forming process after layering and stacking, the interlayer bonding force of the multi-layer fiber structure is enhanced, the fabric forms a complete and compact whole, and the structure carrier is relatively stable, which lays a foundation for further optimizing the fabric function and promoting its application in related fields.

[0038] The application will be further described below in combination with specific examples.

[0039] Example 1 (S1): Preparation of outer layer PAN (polyacrylonitrile) 20 wt%, emodin 5 wt%, solvent DMF (dimethylformamide) 20 ml; middle layer PA6 (polycaprolactam, nylon 6) 20 wt%, berberine 5 wt%, formic acid:acetic acid = 1:1 (volume ratio) 20 ml; inner layer TPU (thermoplastic polyurethane) 20 wt%, scutellarein 5 wt%, DMF:THF (tetrahydrofuran) = 1:1, siloxane 7 wt%. Spinning voltage 20 kV, distance 15 cm, flow rate 0.8 mL / h, 25 °C, spinning environment humidity 30-40 %RH; hot-pressing at 60 °C, 0.20 MPa, 1 min. Spun composite fabric areal density 23.1±1.2 g / m², thickness 245±15 μm. Outer layer fiber diameter 420±80 nm, middle layer fiber diameter 81±17 nm, inner layer fiber diameter 925±84 nm. Outer layer fiber layer thickness 123±8 nm, middle layer fiber thickness 82±6 nm, inner layer fiber thickness 41±4 nm.

[0040] Example 2 (S2): Preparation of outer layer PAN 20 wt%, emodin 10 wt%, solvent DMF 20 ml; middle layer PA6 20 wt%, berberine 10 wt%, formic acid:acetic acid = 1 : 1 (volume ratio) 20 ml; inner layer TPU 20 wt%, baicalin 10 wt%, DMF:THF = 1 : 1, silicone 7 wt%. Spinning voltage 20 kV, distance 15 cm, flow rate 0.8 mL / h, 25 °C, spinning environment humidity 30-40 %RH; 60 °C, 0.20 MPa, 1 min hot pressing. Spun composite fabric areal density 23.1±1.2 g / m2, thickness 245±15 μm.

[0041] Example 3 (S3): Preparation of outer layer PAN 20 wt%, emodin 20 wt%, solvent DMF 20 ml; middle layer PA6 20 wt%, berberine 20 wt%, formic acid:acetic acid = 1 : 1 (volume ratio) 20 ml; inner layer TPU 20 wt%, baicalin 20 wt%, DMF:THF = 1 : 1, silicone 7 wt%. Spinning voltage 20 kV, distance 15 cm, flow rate 0.8 mL / h, 25 °C, spinning environment humidity 30-40 %RH; 60 °C, 0.20 MPa, 1 min hot pressing. Spun composite fabric areal density 23.1±1.2 g / m2, thickness 245±15 μm.

[0042] Comparative Example C1 : Preparation of outer layer PAN 20 wt%, emodin:berberine:baicalin in a ratio of 1 : 1 : 1, and the total mass concentration is 10 wt%, solvent DMF 20 ml; middle layer PA6 20 wt%, emodin:berberine:baicalin in a ratio of 1 : 1 : 1, and the total mass concentration is 10 wt%, formic acid:acetic acid = 1 : 1 (volume ratio) 20 ml; inner layer TPU 20 wt%, emodin:berberine:baicalin in a ratio of 1 : 1 : 1, and the total mass concentration is 10 wt%, DMF:THF = 1 : 1, silicone 7 wt%. Spinning voltage 20 kV, distance 15 cm, flow rate 0.8 mL / h, 25 °C, spinning environment humidity 30-40 %RH; 60 °C, 0.20 MPa, 1 min hot pressing. Spun composite fabric areal density 23.1±1.2 g / m2, thickness 245±15 μm.

[0043] Comparative Example C2: Preparation of outer layer PAN 20 wt%, solvent DMF 20 ml; middle layer PA6 20 wt%, formic acid:acetic acid = 1:1 (volume ratio) 20 ml; inner layer TPU 20 wt%, DMF:THF = 1:1, siloxane 7 wt%. Spinning voltage 20 kV, distance 15 cm, flow rate 0.8 mL / h, 25 °C, spinning environment humidity 30-40 %RH; 60 °C, 0.20 MPa, 1 min hot-pressing. Spun composite fabric areal density 23.1±1.2 g / m2, thickness 245±15 μm.

[0044] Comparative Example O1: Preparation of inner layer PAN 20 wt%, emodin 10 wt%, solvent DMF 20 ml; middle layer PA6 20 wt%, berberine 10 wt%, formic acid:acetic acid = 1:1 (volume ratio) 20 ml; outer layer TPU 20 wt%, baicalin 10 wt%, DMF:THF = 1:1, siloxane 7 wt%. Spinning voltage 20 kV, distance 15 cm, flow rate 0.8 mL / h, 25 °C, spinning environment humidity 30-40 %RH; 60 °C, 0.20 MPa, 1 min hot-pressing. Spun composite fabric areal density 23.1±1.2 g / m2, thickness 245±15 μm. The only difference from Example 1 is the order of the outer / middle / inner three layers.

[0045] Comparative Example O2: Preparation of inner layer PAN 20 wt%, emodin 10 wt%, solvent DMF 20 ml; middle layer PA6 20 wt%, berberine 10 wt%, formic acid:acetic acid = 1:1 (volume ratio) 20 ml; outer layer TPU 20 wt%, baicalin 10 wt%, DMF:THF = 1:1, siloxane 7 wt%. Spinning voltage 20 kV, distance 15 cm, flow rate 0.8 mL / h, 25 °C, spinning environment humidity 30-40 %RH; 60 °C, 0.20 MPa, 1 min hot-pressing. Spun composite fabric areal density 23.1±1.2 g / m2, thickness 245±15 μm. Outer layer fiber layer thickness 41±5 nm, middle layer fiber thickness 180±10 nm, inner layer fiber thickness 24±4 nm. The difference from Example 2 is the thickness of the outer layer, inner layer, and middle layer is different from Example 2.

[0046] The fiber samples of each example and comparative example were respectively subjected to release property determination, sterilization property evaluation, moisture absorption and quick drying property evaluation, and air permeability evaluation.

[0047] The test methods in the examples are described as follows: (1) Release assay: Accurately weigh 100 mg of fiber sample and place it in a stoppered conical flask. Add 50 mL of deionized water and shake at 37 °C and 130 r / min. Take 3 mL of solution at each set time point and add 3 mL of deionized water simultaneously. Measure the absorbance of the released solution using a UV-Vis spectrophotometer (the absorption peak of baicalin is set at 278 nm, and the absorption peaks of berberine and rhein are set at 265 nm). Calculate the cumulative release rate using the standard curves of the three traditional Chinese medicine components under the same conditions. Calculate using the following formula: Where M0 is the total drug content in the sample, and Mt is the cumulative drug released at time t.

[0048] (2) Evaluation of bactericidal properties: The fiber fabric was cut into 2×2 cm pieces, and the control group used blank fiber (Example C2). The samples were irradiated with ultraviolet light for 30 min. Typical strains (such as Escherichia coli ATCC 25922) were selected and cultured to the logarithmic growth phase. The bacterial concentration was adjusted to 10. 5 CFU / mL: The fiber fabric was placed in 2 mL of bacterial solution and incubated at 37℃ for 2 h. After incubation, the fiber sample was placed in 1 mL of physiological saline and sonicated for 10 min. 100 μL of the eluent was spread on LB agar plates and incubated for 24 h. The CFU reduction rate was calculated. Washing stability test: The washing process was repeated 10 times (warm water 30℃, gentle shaking for 10 min / time). After drying, the steps were repeated, and the sterilization rate after washing was measured. Data analysis: The sterilization rate (%) was calculated as follows: [(control group colony count - sample group colony count) / control group colony count] × 100%.

[0049] (3) Evaluation of moisture absorption and quick-drying properties: According to the method of GB / T 21655.1-2008, the droplet diffusion method is used to measure the ability of the fabric to quickly absorb and wick away sweat, reflecting the dryness and comfort of wearing. The fiber fabric is cut into 5×5 cm pieces, and the fabric is laid out naturally in the horizontal direction with the skin-friendly layer facing up (in this patent, the inner layer is placed facing up). A drop of 50 μL liquid is dropped onto the sample, and the diffusion time of the droplet is recorded.

[0050] (4) Air permeability evaluation: Cut the fiber fabric into 50 cm pieces 2 Size, and the permeation gas volume flow rate was measured using a fabric permeability meter at a constant pressure of 200 Pa.

[0051] The test results are shown in Tables 1 to 3. Figures 1 to 3 .in Figure 1 These are electron microscope images of the three fiber layers in Example 1. Figure 2 This is a comparison chart of the fiber mechanical properties of various embodiments. Figure 3 This is a comparison chart of the total cumulative drug release in each embodiment.

[0052] The structure, contact angle, air permeability, and mechanical properties of the fiber material are shown in Table 1. Table 1. Structure, contact angle, air permeability and mechanical properties of fiber materials As can be seen from Table 1: Fiber diameter: The outer layer (420±80~615±110nm), middle layer (81±17~123±21nm), and inner layer (925±84~1325±110nm) of Examples S1-S3 have uniform diameters and exhibit a gradient distribution. In contrast, the diameters of each layer (700±130 / 350±80 / 1400±120nm) of the blended comparative example C1 fluctuate more. This is because the three components in C1 are prone to precipitation when blended, which disrupts the uniformity of the spinning solution and leads to uneven fiber forming diameter. In the examples, due to the single component loading, the spinning solution is stable, and the fiber diameter is more controllable.

[0053] Pore ​​size distribution: In Examples S1-S3, the outer layer pore size (2.0±0.5~2.6±0.7μm), middle layer (3.6±0.8~4.2±1.1μm), and inner layer (6.0±1.0~7.8±1.6μm) exhibit a gradient of "smaller outside and larger inside". However, in O1, due to the reversed layer sequence, the pore size exhibits a gradient of "larger outside and smaller inside" (outer layer 6.50±1.2μm, inner layer 2.1±0.6μm). This gradient pore size is key to achieving moisture absorption and perspiration. The "smaller outside and larger inside" pore size in Examples S1 can guide sweat to diffuse from the inner layer (skin-friendly layer) to the outer layer, while the reversed pore size in O1 hinders sweat excretion.

[0054] Hydrophilicity and hydrophobicity: The difference in water contact angle between the outer and inner layers of Examples S1-S3 is ≥45° (53° for S1 / S2 and 45° for S3), which meets the functional requirements of "hydrophilic outer layer for moisture absorption + hydrophobic inner layer for water resistance"; while C1 has a difference of only 23° due to the blending of layers, which leads to confusion in the hydrophilicity and hydrophobicity between the layers, and cannot achieve waterproof and breathable synergy; although C2 (blank) has a difference of 51°, it has no drug loading and does not have antibacterial function.

[0055] The antibacterial test results are shown in Table 2: Table 2 Antibacterial rate (freshly prepared vs. washed 10 times) As can be seen from the above: Antibacterial rate of newly prepared samples: The antibacterial rates of Examples S1-S3 increased with increasing loading (S1 90.0%, S2 95.0%, S3 98.0%), while C1 (blended 10wt%) only achieved 60.0%, and C2 showed no antibacterial activity. Because the three components were layered and loaded in the examples, their synergistic antibacterial effects were fully utilized (emodin provides broad-spectrum antibacterial activity, berberine inhibits bacterial proliferation, and baicalin disrupts bacterial biofilms). However, blending in C1 resulted in the ineffective interaction of components, significantly reducing the antibacterial efficiency.

[0056] Water washing stability: After 10 water washes, the antibacterial rate of the examples remained at 85.0%~92.0% (S1 85.0%, S2 90.0%, S3 92.0%), while that of C1 was only 30.0% - the reason is that the drug in the examples is more tightly bound to the polymer substrate (single component loading without precipitation, drug molecules are uniformly dispersed in the substrate), and is not easily lost during water washing; in C1, the drug exists in the form of precipitation, has weak binding force with the substrate, is easily washed away by water, and leads to a rapid decline in antibacterial activity.

[0057] The moisture absorption and quick-drying properties are shown in Table 3: Table 3 Moisture Absorption and Quick-Drying Properties Example vs. Sequence Comparison: The droplet complete diffusion time of S1 is only 2.8±0.4s, while that of O1 (reversed sequence) is 12.0±2.0s and that of O2 (changed layer thickness) is 36.0±4.1s. The core is the sequence and gradient pore size of S1, which is "inner layer (hydrophobic TPU) - middle layer (PA6) - outer layer (hydrophilic PAN)," which can quickly guide droplets (simulating sweat) to diffuse from the inner layer to the outer layer. After the sequence of O1 is reversed, the hydrophobic outer layer hinders the diffusion of droplets. In O2, due to the inner layer being too thin (24±4nm) and the outer layer being too thick (41±5nm), the droplet transmission path between layers is blocked, and the moisture absorption and quick-drying properties are significantly reduced. This proves that "specific sequence + reasonable layer thickness" is the key to achieving moisture absorption and quick-drying properties.

[0058] pass Figure 1 The electron micrographs of the three fiber layers in Example 1 clearly demonstrate their microstructure, proving that the fibers have uniform diameter and no obvious precipitation under single-component loading, providing microstructural support for excellent mechanical properties and drug release performance; among them, Figure 1 The TPU in the text refers to the inner baicalin fiber layer, which mainly uses TPU (thermoplastic polyurethane) as a precursor. Figure 1 PA6 in the text is the designation of the middle layer of berberine fiber, which mainly uses PA6 (polycaprolactam, nylon 6) as a precursor. Figure 1PAN in the figure represents the outer emodin fiber layer, which primarily uses PAN (polyacrylonitrile) as a precursor. The microstructure of the inner baicalin fiber layer, the middle berberine fiber layer, and the outer emodin fiber layer demonstrates that under single-component loading, the fiber diameter is uniform and there is no significant precipitation, providing microstructural support for excellent mechanical properties and drug release performance.

[0059] Figure 2 The comparison chart of fiber mechanical properties of each embodiment shows that the quantitative verification of the effect of "layered loading" on improving mechanical properties clarifies that the optimal drug loading (10 wt%, 10 wt% emodin, 10 wt% berberine, 10 wt% baicalin) is found in Example 2, providing a basis for parameter selection in actual production.

[0060] Figure 3 The comparison chart of total cumulative drug release in each embodiment shows that the advantages of layered loading for drug release are visually presented, proving that embodiments 1 to 3 of this application can avoid burst release and achieve stable drug release, which meets the "long-lasting efficacy" requirement of medical dressings.

[0061] Examples 1 (S1), 2 (S2), and 3 (S3) of this application all employ a "single fiber loading a single component" strategy and a specific layered electrospinning process, exhibiting excellent results: all three achieve stable loading of baicalin, berberine, and emodin; the fabric surface density and thickness are uniform and meet design requirements; the fiber diameter is uniform (50nm-2μm); the interlayer water contact angle difference is ≥45°, providing a good foundation for waterproofing and breathability; the antibacterial performance increases with increasing drug loading, with newly prepared samples showing an antibacterial rate of 90.0%-98.0%, which remains at 85.0%-92.0% after 10 washes; in terms of mechanical properties, S2 (10wt%) exhibits the best tensile breaking strength at 17MPa, while S1 (5wt%) and S3 (20wt%) show strengths of 12MPa and 10MPa respectively, all meeting practical requirements; excellent moisture absorption and quick-drying properties are also observed in S1. The droplet diffusion time was only 2.8±0.4s; the drug release was stable with no obvious burst release, and the release stability was improved by 60% compared with the blended control (C1), which fully verified the advantages of this technical solution in terms of component loading, performance stability and functional synergy.

[0062] The aforementioned Sanhuang Xiexin Decoction fiber fabric, through its layered structural design of "inner baicalin fiber layer - middle berberine fiber layer - outer emodin fiber layer," loads the three active ingredients—baicalin, berberine, and emodin—on separate fiber carriers. This fundamentally avoids the solubility conflicts and precipitation problems caused by co-loading of the three components, effectively improving drug loading capacity and significantly enhancing drug loading efficiency while ensuring good drug release stability. Furthermore, the hot-pressing process after layering enhances the interlayer bonding of the multi-layered fiber structure, allowing the fabric to form a complete and compact whole, making the structural carrier relatively stable. This lays the foundation for further optimization of fabric function and promotion of its application in related fields.

[0063] This application discloses a method for preparing Sanhuang Xiexin Decoction fiber fabric by electrospinning, belonging to the field of functional fibers of traditional Chinese medicine. Using emodin, berberine, and baicalin as active ingredients, they are dissolved in polymer-solvent systems with matching solubility. Single-component drug fiber layers are formed by electrospinning using a "single fiber loading single component" strategy, and then composited into multi-layer fabrics according to a specific hydrophilic / hydrophobic arrangement. The total loading of the three traditional Chinese medicines in the fabric is 5-20 wt%. This fabric possesses long-lasting antibacterial, waterproof, breathable, moisture-absorbing, and perspiration-wicking functions, and is significantly superior to the control sample prepared by blended spinning in terms of antibacterial duration, drug release stability, and fabric mechanical properties. It can be used for compound delivery, surface antibacterial applications, wound dressings, and protective textiles.

[0064] In this application, the mass ratio of the three active ingredients of traditional Chinese medicine is 1.5-3.0 : 1 : 0.5-2.0 (emodin: berberine: baicalin). The cumulative drug release of the fiber fabric obtained by layering and loading the three traditional Chinese medicines is 60% higher than that of the fiber fabric obtained by blending traditional Chinese medicines. The multi-component traditional Chinese medicine fiber fabric of this application has long-lasting bactericidal, waterproof, breathable, and moisture-wicking functions. Its tensile strength is ≥20 MPa, air permeability is ≥260 mm / s, water contact angle is 90-135°, and after 10 washes, the antibacterial rate is ≥90%.

[0065] This application has the following advantages: 1. By adopting the strategy of "single fiber loading single component", the interaction and precipitation problems caused by the different solubility of various core components in Sanhuang Xiexin Decoction, such as baicalin, rhein, and berberine, are fundamentally avoided in the fiber carrier. This significantly improves the release stability, drug loading efficiency and release time of each component. Moreover, the fiber fabric can maintain its release within 10 washes during the washing process. 2. By selecting polymer substrates and solvents based on the characteristics of each component, the spinnability of the spinning solution is optimized, resulting in fibers with uniform diameter (50nm-2μm), improved spinning stability, and enhanced fiber mechanical strength.

[0066] 3. Through layered spinning, the three components are synergistically released. By combining the hydrophilic and hydrophobic properties and pore structure adjustment of different polymer fiber materials, the fabric has the functions of long-lasting sterilization, moisture absorption, perspiration wicking, waterproofing and breathability.

[0067] The technical features of the embodiments described above can be combined arbitrarily. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as the combination of these technical features does not contradict each other, it should be considered within the scope of this specification. It should be noted that the terms "in one embodiment," "for example," and "again," etc., in this application are intended to illustrate the application and not to limit it. The embodiments described above only illustrate several implementations of the present invention, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of the invention patent. It should be pointed out that for those skilled in the art, several modifications and improvements can be made without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this patent should be determined by the appended claims.

Claims

1. A fiber fabric made from Sanhuang Xiexin Decoction, characterized in that, The Sanhuang Xiexin Decoction fiber fabric has a three-layer structure, consisting of an inner baicalin fiber layer, a middle berberine fiber layer, and an outer emodin fiber layer stacked sequentially and formed by hot pressing. The inner baicalin fiber layer is loaded with baicalin, the middle berberine fiber layer is loaded with berberine, and the outer emodin fiber layer is loaded with emodin.

2. The Sanhuang Xiexin Decoction fiber fabric according to claim 1, characterized in that, The total loading of the three active ingredients of traditional Chinese medicine, namely emodin, berberine and baicalin, in the Sanhuang Xiexin Decoction fiber fabric is 5-20 wt%, and / or the mass ratio of emodin, berberine and baicalin is "1.5-3.0":1:"0.5-2.0".

3. The Sanhuang Xiexin Decoction fiber fabric according to claim 1 or 2, characterized in that, The inner baicalin fiber layer is formed by using polyurethane as a polymer substrate, loading baicalin, and adding 5-15 wt% of siloxane hydrophobic modifier. The fiber layer is prepared using a mixed solvent of N,N-dimethylformamide and tetrahydrofuran. And / or, the middle berberine fiber layer is formed by loading berberine onto a polyamide, chitosan, or silk fibroin polymer as a substrate, and the fiber layer is prepared using a mixed solvent of formic acid and acetic acid. And / or, the outer emodin fiber layer is formed by loading emodin onto polylactic acid or polyacrylonitrile polymer as a substrate, and one or more of chloroform, acetone, and N,N-dimethylformamide are used as solvents during the preparation of the fiber layer.

4. The Sanhuang Xiexin Decoction fiber fabric according to claim 3, characterized in that, The inner baicalin fiber layer is formed by spinning using a baicalin spinning solution. The baicalin spinning solution uses polyurethane as the polymer base material and N,N-dimethylformamide and tetrahydrofuran as the solvent in a volume ratio of 3:1 to 1:

1. The mass concentration of the polymer solution is 5-30%, the mass concentration of baicalin is 5-20%, and 5-15 wt% of a siloxane hydrophobic modifier is added. The humidity during the spinning process is controlled at 30-90%. And / or, the middle berberine fiber layer is formed by a spinning process using berberine spinning solution. The berberine spinning solution uses polyamide, chitosan, or silk fibroin as the polymer substrate for electrospinning, and the solvent is a mixture of formic acid and acetic acid in a volume ratio of 1:

1. The mass concentration of the polymer solution is 8-20%, the mass concentration of berberine is 5-20%, and the humidity during the spinning process is controlled at 30-40%. And / or, the outer emodin fiber layer is formed by a spinning process using an emodin spinning solution. The emodin spinning solution uses polylactic acid or polyacrylonitrile as the polymer substrate for electrospinning, and the solvent is one or more of chloroform, acetone, and N,N-dimethylformamide. The mass concentration of the polymer solution is 5-30%, the mass concentration of emodin is 5-20%, and the humidity during the spinning process is controlled at 30-40%.

5. The Sanhuang Xiexin Decoction fiber fabric according to claim 4, characterized in that, The fabric has a surface density of 15-35 g / m² and a thickness of 100-400 μm.

6. The Sanhuang Xiexin Decoction fiber fabric according to claim 4, characterized in that, In the Sanhuang Xiexin Decoction fiber fabric, the diameter of a single fiber is 50nm-2μm; And / or, the difference in water contact angle between the hydrophilic outer emodin fiber layer and the hydrophobic inner baicalin fiber layer is ≥45°, preferably, the difference in water contact angle between the hydrophilic outer emodin fiber layer and the hydrophobic inner baicalin fiber layer is ≥50°; Preferably, the outer emodin fiber layer has a pore size of 1.5 micrometers to 3.3 micrometers, the middle berberine fiber layer has a pore size of 2.9 micrometers to 5.3 micrometers, and the inner baicalin fiber layer has a pore size of 5.0 micrometers to 9.4 micrometers.

7. The Sanhuang Xiexin Decoction fiber fabric according to claim 4, characterized in that, The baicalin spinning solution contains 10% baicalin by mass. And / or, the berberine spinning solution has a berberine mass concentration of 10%; And / or, the mass concentration of emodin in the emodin spinning solution is 10%; And / or, the mass ratio of emodin, berberine, and baicalin is 1:1:1; And / or, the inner baicalin fiber layer is made of polyurethane as the polymer substrate, the middle berberine fiber layer is made of polyamide as the substrate, and the outer emodin fiber layer is made of polyacrylonitrile as the substrate.

8. A method for preparing a Sanhuang Xiexin Decoction fiber fabric as described in any one of claims 1 to 7, characterized in that, Includes the following steps: Emodin spinning solution, baicalin spinning solution and berberine spinning solution were prepared respectively. Using emodin spinning solution, baicalin spinning solution and berberine spinning solution as raw materials, the three spinning solutions are spun in the order of "baicalin fiber layer - berberine fiber layer - emodin fiber layer" through layered electrospinning technology. The three spinning solutions are then directly superimposed on the receiving device to form a multi-layer fiber structure with corresponding baicalin fiber layer, berberine fiber layer and emodin fiber layer. The multi-layered fiber structure is hot-pressed to form the Sanhuang Xiexin Decoction fiber fabric.

9. The preparation method according to claim 8, characterized in that, In the emodin spinning solution, polylactic acid or polyacrylonitrile polymers are used as the polymer substrate for electrospinning, and the solvent is one or more of chloroform, acetone, and N,N-dimethylformamide; the mass concentration of the polymer solution is 5-30%, and the mass concentration of emodin is 5-20%; the ambient humidity during the spinning process is controlled at 30-40%. And / or, in the baicalin spinning solution, polyurethane is used as the polymer matrix, and the solvent is a mixture of N,N-dimethylformamide and tetrahydrofuran in a volume ratio of 3:1 to 1:1; the mass concentration of the polymer solution is 5-30%, the mass concentration of baicalin is 5-20%, and 5-15 wt% of a siloxane hydrophobic modifier is added to the spinning solution; the ambient humidity during the spinning process is controlled at 30-90%. And / or, in the berberine spinning solution, polyamide, chitosan, or silk fibroin polymers are used as the polymer substrate for electrospinning, and the solvent is a mixture of formic acid and acetic acid in a 1:1 volume ratio; the mass concentration of the polymer solution is 8-20%, and the mass concentration of berberine is 5-20%; the ambient humidity during the spinning process is controlled at 30-40%. And / or, in layered electrospinning, the voltage is controlled at 15-35 kV, the receiving distance is 12-20 cm, the liquid feed rate is 0.3-2 mL / h, and the ambient temperature is maintained at 25℃; And / or, in hot pressing, hot pressing is performed at 40-100℃ and 0.1-0.3 MPa.

10. The application of the Sanhuang Xiexin Decoction fiber fabric as described in any one of claims 1 to 7, or the Sanhuang Xiexin Decoction fiber fabric prepared by the preparation method as described in claim 8 or 9, in the fields of medical dressings and protective textiles.

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