Plant management module and preparation device and preparation method of positive reference substance

Abstract

The invention relates to the technical field of positive sample preparation, in particular to a tube implanting module and a preparation device and method of a positive reference substance, the preparation device comprises a clamping assembly and a processing assembly, and the clamping assembly is used for clamping a target sample. The machining assembly comprises a plurality of machining modules, each machining module and the clamping assembly can move relatively, and when the machining modules correspond to the clamping assembly and are located at the machining stations of the target samples, the machining modules conduct machining treatment on the target samples. Wherein the plurality of processing modules comprise a punching module and a pipe planting module, and the punching module can perform punching treatment on the target sample so as to form a hole in the target sample. And the tube implanting module can perform tube implanting treatment on the target sample so as to implant a microtube into the hole. According to the preparation device, the target sample is subjected to punching treatment and tube implanting treatment through the punching module and the tube implanting module, part of manual operation is replaced, micro-tube implanting is completed, and the preparation efficiency of the positive reference substance is effectively improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of positive sample preparation, and particularly relates to a plant pipe module, a preparation device of a positive control sample and a preparation method thereof. BACKGROUND

[0002] In order to ensure that a drug product meets safety and quality requirements, in the actual production process of the drug product, a leak detection machine is used to test the sealing integrity of a drug product packaging system. Common test methods of the leak detection machine include vacuum decay method and high-voltage discharge method. However, no matter which test method is used, a positive control sample needs to be used in the test process. The positive control sample refers to a drug product packaging system with a known defect leak.

[0003] At present, the positive control sample is generally prepared by manually implanting a micro tube into a drug product packaging to obtain a positive control sample with a known defect leak. The positive control sample is required for the capability verification of the leak detection machine, the development of a detection method and the verification of a single product. However, the manual preparation method is slow and cannot meet the detection and verification requirements of the leak detection machine, which affects the production cycle of the drug product. Meanwhile, the manual preparation process is prone to cause the tip of the micro tube to break, resulting in an unqualified positive control sample. SUMMARY

[0004] The present application aims to at least solve one of the problems in the related art.

[0005] In a first aspect, the present application provides a preparation device of a positive control sample, comprising a clamping assembly and a processing assembly. The clamping assembly is used to clamp a target sample. The processing assembly comprises a plurality of processing modules. Each processing module is capable of relative movement with the clamping assembly. When the processing module and the clamping assembly correspond to each other and are located at a processing station of the target sample, the processing module processes the target sample. The plurality of processing modules comprises a punching module and a plant pipe module. The punching module is capable of punching the target sample to form a hole on the target sample. The plant pipe module is capable of implanting a micro tube into the hole.

[0006] In an optional embodiment, the punching module comprises a first housing, a first driving part and a drill bit part. The first driving part is connected with the first housing. The drill bit part is arranged on a driving end of the first driving part. The first driving part is capable of driving the drill bit part to rotate relative to the first housing to form a hole on the target sample.

[0007] In an optional embodiment, the plant pipe module comprises a mounting seat, a tube conveying channel and a conveying assembly. The tube conveying channel is arranged on the mounting seat and is used to convey the micro tube. When the plant pipe module is located at the processing station of the target sample, a tube conveying port of the tube conveying channel is opposite to the hole. The conveying assembly is arranged on the mounting seat and is used to move the micro tube in the tube conveying channel to the tube conveying port.

[0008] In an alternative embodiment, the tube channel comprises a top-opened tube groove. The delivery assembly comprises a delivery wheel, a wheel surface of the delivery wheel being capable of contacting the microtube, the delivery wheel being rotatable relative to the mounting base to drive the microtube to move within the tube groove.

[0009] In an alternative embodiment, the tube implanting module comprises a fixing plate, the fixing plate being movably arranged on the mounting base, the fixing plate having a pressing position and a releasing position, the fixing plate being arranged on the microtube within the tube groove when being at the pressing position, the fixing plate being away from the tube groove when being at the releasing position.

[0010] In an alternative embodiment, the tube implanting module comprises a positioning tube, the positioning tube being arranged on the mounting base, the positioning tube being in communication with the tube port, the microtube being capable of moving to the hole through the tube channel and the positioning tube.

[0011] In an alternative embodiment, the inner diameter of the positioning tube gradually decreases in a direction away from the tube channel.

[0012] In an alternative embodiment, the positioning tube comprises a tube body and a flexible body, the tube body being arranged on the mounting base, one end of the tube body being in communication with the tube port. The flexible body is arranged at the other end of the tube body, the flexible body being capable of contacting the hole wall of the hole.

[0013] In an alternative embodiment, the flexible body comprises a plurality of positioning ribs and a connecting rib, the plurality of positioning ribs being spaced apart and connected to the other end of the tube body, free ends of the positioning ribs being capable of extending into the hole. The connecting rib is connected to the plurality of positioning ribs and arranged close to the tube body.

[0014] In an alternative embodiment, the processing module further comprises a dust removal module, the dust removal module being capable of performing a dust removal process on the target sample to remove residual dust within the hole.

[0015] In an alternative embodiment, the processing module further comprises a solidification module, the solidification module being capable of performing a solidification process on the target sample to solidify the microtube within the hole.

[0016] In an alternative embodiment, the processing module further comprises a cutting module, the cutting module being capable of performing a cutting process on the target sample to adjust the length of the microtube after the solidification process.

[0017] In an alternative embodiment, the dust removal module comprises a second housing, a plasma generator and an air outlet tube, the plasma generator being connected to the second housing. The air outlet tube is connected to the plasma generator, the air outlet tube being capable of delivering plasma wind generated by the plasma generator to the hole of the target sample.

[0018] In an alternative embodiment, the solidification module comprises an ultraviolet generator, and the hole of the target sample is located within the ultraviolet light range of the ultraviolet generator.

[0019] In an alternative embodiment, the pipe cutting module comprises a third housing, a second driving part and a cutting part, the second driving part is connected with the third housing. The cutting part is arranged on the driving end of the second driving part, and the second driving part can drive the cutting part to rotate to cut the micro-pipe after the solidification treatment.

[0020] In an alternative embodiment, the pipe cutting module further comprises a collection groove, and the groove opening of the collection groove is located below the cutting part.

[0021] In an alternative embodiment, the clamping assembly comprises a first clamping arm and a second clamping arm, and the second clamping arm can move relative to the first clamping arm to clamp the target sample between the first clamping arm and the second clamping arm.

[0022] In an alternative embodiment, the clamping assembly further comprises a clamping seat, an avoiding hole, a connecting rod and a fastener, the first clamping arm and the second clamping arm are arranged on the clamping seat. The avoiding hole is arranged on the second clamping arm. The connecting rod is connected to the first clamping arm through the avoiding hole. The fastener is connected to the connecting rod and located on the side of the second clamping arm away from the first clamping arm.

[0023] In an alternative embodiment, the preparation device further comprises a plurality of adjusting modules, and the plurality of adjusting modules are respectively connected to the plurality of processing modules, for adjusting the position to be processed of the target sample clamped by the clamping assembly when the processing module is located at the processing station of the corresponding clamping assembly.

[0024] In an alternative embodiment, the adjusting module comprises a connecting column and a connecting seat, the connecting seat is rotatably installed on the connecting column through a connecting shaft, the processing module is arranged on the connecting seat, and the position of the target sample clamped by the clamping assembly can be adjusted by rotating the connecting seat.

[0025] In an alternative embodiment, the adjusting module further comprises a rotating groove, a first shaft hole and a second shaft hole, the rotating groove is arranged at one end of the connecting column, and a part of the connecting seat is located in the rotating groove. The first shaft hole is arranged on the opposite two side walls of the connecting column, and the first shaft hole is in communication with the rotating groove. The second shaft hole is arranged on the connecting seat, and the connecting shaft passes through the second shaft hole and the first shaft hole respectively, so that the connecting seat and the connecting column are rotatably connected.

[0026] In an alternative embodiment, the preparation device further comprises a locking assembly, and the locking assembly is used to limit the relative movement between the processing module and the clamping assembly when the processing module is located at the processing station of the target sample.

[0027] In an alternative embodiment, the locking assembly comprises a first locking seat, a plurality of second locking seats, and a locking portion. The first locking seat is fixedly assembled with one of the machining module or the clamping assembly. The plurality of second locking seats are respectively fixedly assembled with the other of the machining module or the clamping assembly. The locking portion is arranged on the first locking seat, and the locking portion is selectively connected with one of the plurality of second locking seats.

[0028] In an alternative embodiment, the second locking seat comprises a matching hole. The locking portion comprises a locking pin, which is movable relative to the first locking seat, and in the locking position, the locking pin extends into the matching hole for locking.

[0029] In an alternative embodiment, the machining module and the clamping assembly are relatively rotatable or relatively movable.

[0030] In an alternative embodiment, the preparation device further comprises a first base and a second base. One of the clamping assembly and the machining assembly is arranged on the first base. The other of the clamping assembly and the machining assembly is arranged on the second base. The first base and the second base are relatively movable.

[0031] In an alternative embodiment, the number of the first bases is one or more, and the number of the second bases is one or more.

[0032] In an alternative embodiment, the second base is movable relative to the first base. The number of the clamping assemblies is one or more, and the clamping assemblies are arranged on the same or different first bases. The plurality of machining modules are arranged on the same or different second bases.

[0033] In an alternative embodiment, the second base is movable relative to the first base. The number of the clamping assemblies is one or more, and the clamping assemblies are arranged on the same or different second bases. The plurality of machining modules are arranged on the same or different first bases.

[0034] In an alternative embodiment, the preparation device further comprises a support table. The first base and the second base are arranged on the support table, and an assembly space is formed between the first base and the support table. The second base is arranged around the first base and located in the assembly space.

[0035] In an alternative embodiment, the first base is a circular table, and the second base is an annular table. The second base can be sleeved outside the first base and relatively rotate around the first base.

[0036] In a second aspect, the present application provides a tube implanting module for implanting a microtube into a hole of a target sample in preparation of a positive control, the tube implanting module comprising a mounting base, a tube channel and a tube delivery assembly, the tube channel is arranged on the mounting base, the tube channel is used for delivering the microtube, and a tube opening of the tube channel is used for being opposite to the hole on the target sample. The tube delivery assembly is arranged on the mounting base, and the tube delivery assembly is used for moving the microtube in the tube channel to the tube opening and implanting the microtube into the hole on the target sample.

[0037] In an alternative embodiment, the tube channel comprises a top-opened tube groove. The tube delivery assembly comprises a tube delivery wheel, a wheel surface of the tube delivery wheel is capable of contacting the microtube, and the tube delivery wheel rotates relative to the mounting base to drive the microtube to move in the tube groove.

[0038] In an alternative embodiment, the tube implanting module comprises a fixing press, the fixing press is movably arranged on the mounting base, the fixing press has a pressing position and a releasing position, the fixing press is arranged on the microtube in the tube groove when the fixing press is in the pressing position, and the fixing press is away from the tube groove when the fixing press is in the releasing position.

[0039] In an alternative embodiment, the tube implanting module comprises a positioning tube, the positioning tube is arranged on the mounting base, the positioning tube is communicated with the tube opening, and the microtube moves to the hole through the tube channel and the positioning tube.

[0040] In an alternative embodiment, the inner diameter of the positioning tube gradually decreases in a direction away from the tube channel.

[0041] In an alternative embodiment, the positioning tube comprises a tube body and a flexible body, the tube body is arranged on the mounting base, and one end of the tube body is communicated with the tube opening. The flexible body is arranged on the other end of the tube body, and the flexible body is capable of contacting a hole wall of the hole.

[0042] In an alternative embodiment, the flexible body comprises a plurality of positioning ribs and a connecting rib, the plurality of positioning ribs are spaced apart and connected to the other end of the tube body, and free ends of the positioning ribs are capable of extending into the hole. The connecting rib is connected to the plurality of positioning ribs and arranged close to the tube body.

[0043] In a third aspect, the present application provides a method for preparing a positive control, the method is implemented by using the positive control preparation device in any of the above-mentioned embodiments, and the method comprises the following steps: clamping the target sample by using the clamping assembly; controlling relative movement of the clamping assembly and the hole forming module, so that the hole forming module is located at a processing station of the target sample; performing hole forming treatment on the target sample by using the hole forming module, so as to form a hole on the target sample; controlling relative movement of the clamping assembly and the tube implanting module, so that the tube implanting module is located at the processing station of the target sample; The target sample is treated by the tube implanting module to implant the microtubes in the holes.

[0044] In an alternative embodiment, the preparation method further comprises: Controlling relative movement of the clamping assembly and the dust removal module to position the dust removal module at the processing station of the target sample; The target sample is treated by the dust removal module to remove residual dust in the holes.

[0045] In an alternative embodiment, the preparation method further comprises: Controlling relative movement of the clamping assembly and the solidification module to position the solidification module at the processing station of the target sample; The target sample is treated by the solidification module to solidify the microtubes in the holes.

[0046] In an alternative embodiment, the preparation method further comprises: Controlling relative movement of the clamping assembly and the tube cutting module to position the tube cutting module at the processing station of the target sample; The target sample is treated by the tube cutting module to adjust the length of the microtubes after the solidification treatment.

[0047] Compared with the prior art, the application has the following advantages: The clamping assembly and the processing module of the preparation device of the positive control provided in the application can move relative to each other to adjust the position between the processing module and the target sample. When the processing module is at the processing station of the target sample, the target sample is treated by the punching module and the tube implanting module to punch and implant microtubes, replacing part of the manual operation, completing the implantation of the microtubes, effectively improving the preparation speed of the positive control, allowing the supply quantity of the positive control to meet the detection needs of the leak detection machine, and avoiding affecting the production cycle of the medicine. At the same time, by implanting the microtubes in the target sample through the tube implanting module, the number of broken tips of the microtubes can be significantly reduced, and the success rate of the positive control production can be improved. In addition, when multiple processing modules simultaneously perform processing treatment, the simultaneous preparation of multiple target samples can be realized, and the preparation efficiency of the positive control can be further improved. BRIEF DESCRIPTION OF DRAWINGS

[0048] Figure 1 An exploded view of the preparation device of the positive control of one embodiment provided by the application is shown; Figure 2 A structural schematic view of the preparation device of the positive control of one embodiment provided by the application is shown; Figure 3 An exploded view of the punching module in one embodiment provided by the application is shown; Figure 4A structural diagram of a punching module in one embodiment of the present application is shown. Figure 5 An exploded view of a drill head in a punching module in one embodiment of the present application is shown. Figure 6 A structural diagram of a tube implanting module in one embodiment of the present application is shown. Figure 7 One of the partial enlarged views of a positioning tube in a tube implanting module in one embodiment of the present application is shown. Figure 8 The second partial enlarged view of a positioning tube in a tube implanting module in one embodiment of the present application is shown. Figure 9 A schematic diagram of a tube implanting module in one embodiment of the present application is shown. Figure 10 A schematic diagram of a positioning tube in a tube implanting module in one embodiment of the present application is shown. Figure 11 A structural diagram of a dust removing module in one embodiment of the present application is shown. Figure 12 A structural diagram of a solidifying module in one embodiment of the present application is shown. Figure 13 A structural diagram of a tube cutting module in one embodiment of the present application is shown. Figure 14 A structural diagram of a clamping assembly in one embodiment of the present application is shown. Figure 15 A structural diagram of an adjusting module in one embodiment of the present application is shown. Figure 16 A structural diagram of a locking assembly in one embodiment of the present application is shown. Figure 17 A flow chart of a method for preparing a positive control in one embodiment of the present application is shown.

[0049] Reference signs 1 clamping assembly, 11 first clamping arm, 12 second clamping arm, 13 clamping seat, 14 connecting rod, 15 fastener; 2 punching module, 21 first housing, 22 first driving part, 23 drill head, 231 drill shaft, 232 drill head, 233 recessed hole, 24 first switch, 25 rotating speed adjusting knob, 26 first heat dissipation opening; 3 planting module, 31 mounting seat, 32 pipe channel, 321 pipe port, 322 pipe groove, 33 conveying wheel, 333 positioning groove, 34 fixed pressing piece, 35 positioning pipe, 351 pipe body, 352 flexible body, 3521 positioning rib, 3522 connecting rib, 36 micro-pipe; 4 dust removal module, 41 second housing, 42 plasma generator, 43 air outlet pipe, 44 second switch, 45 temperature adjusting knob, 46 air speed adjusting knob, 47 generation amount control knob, 48 display screen, 49 second heat dissipation opening; 5 curing module, 51 ultraviolet generator, 52 ultraviolet light source; 6 pipe cutting module, 61 third housing, 62 second driving part, 63 cutting part, 64 collecting groove; 7 adjusting module, 71 connecting column, 711 first shaft hole, 712 rotating groove, 72 connecting seat, 721 second shaft hole, 73 connecting shaft; 8 locking assembly, 81 first locking seat, 82 second locking seat, 821 matching hole, 83 locking part; 91 first base, 92 second base, 93 assembly space, 94 supporting table, 941 annular groove, 95 guide part; 10 target sample, 101 hole. DETAILED DESCRIPTION

[0050] In order to better understand the above technical solutions, the technical solutions of the embodiments of the present application will be described in detail below through the drawings and specific embodiments. It should be understood that the specific features in the embodiments of the present application and the specific embodiments are detailed descriptions of the technical solutions of the embodiments of the present application, and are not limitations of the technical solutions of the present application. In the case of no conflict, the technical features in the embodiments of the present application and the specific embodiments can be combined with each other.

[0051] In a first aspect, the present application provides a preparation device for positive control, as shown in Figure 1 and Figure 2 The preparation device includes a clamping assembly 1 and a processing assembly. The clamping assembly 1 is used for clamping a target sample 10. The processing assembly includes a plurality of processing modules. Each processing module and the clamping assembly 1 can move relative to each other. When the processing module and the clamping assembly 1 correspond to each other and are in a processing station of the target sample 10, the processing module processes the target sample 10. Among them, the plurality of processing modules at least include a punching module 2 and a planting module 3. The punching module 2 can punch the target sample 10 to form a hole 101 on the target sample 10. The planting module 3 can plant the target sample 10 to implant a micro-pipe 36 in the hole 101.

[0052] The processing module and the clamping assembly 1 can move relative to each other, and the relative position between the processing module and the target sample 10 can be adjusted, that is, when the processing module and the clamping assembly 1 correspond to each other and are located at the processing position of the target sample 10, the processing module processes the target sample 10. Specifically, the relative movement between the processing module and the clamping assembly 1 includes various implementation manners, for example, the clamping assembly 1 is fixed, and the processing module can move relative to the clamping assembly 1 to adjust the position between the two. Alternatively, the processing module is fixed, and the clamping assembly 1 can move relative to the processing module. Alternatively, the processing module and the clamping assembly 1 can move.

[0053] It should be noted that the relative movement between the processing module and the clamping assembly 1 can include relative movement and / or relative rotation between the processing module and the clamping assembly 1.

[0054] The preparation device of the positive control provided in the present application can realize the relative movement between the clamping assembly 1 and the processing module, and the position between the processing module and the target sample 10 can be adjusted. When the processing module is located at the processing position of the target sample 10, the target sample 10 is processed by the punching module 2 and the tube implanting module 3, which replaces part of the manual operation, implants the micro tube 36, effectively improves the preparation speed of the positive control, and makes the supply quantity of the positive control meet the detection demand of the leak detection machine, avoids affecting the production cycle of the medicine, implants the micro tube 36 in the target sample 10 through the tube implanting module 3, and can significantly reduce the breaking frequency of the tip of the micro tube 36, and improve the success rate of the positive control.

[0055] It should be noted that the plurality of processing modules in the present application can simultaneously process, that is, simultaneously prepare a plurality of target samples 10, which can further improve the preparation efficiency of the positive control.

[0056] It should be noted that the target sample 10 includes a medicine plate, a soft bag, an eye drop bottle, etc. The medicine plate includes a BFS (Blow Fill Seal) medicine plate.

[0057] In an optional embodiment, as shown in Figure 3 and Figure 4 The punching module 2 includes a first housing 21, a first driving part 22 and a drill bit part 23, and the first driving part 22 is connected with the first housing 21. The drill bit part 23 is arranged on the driving end of the first driving part 22, and the first driving part 22 can drive the drill bit part 23 to rotate relative to the first housing 21 to form a hole 101 on the target sample 10.

[0058] In this embodiment, after the first drive unit 22 is started, the drill head 23 can be rotated relative to the first housing 21 by the drive end, thereby forming a hole 101 on the target sample 10.

[0059] The first drive unit 22 includes a first drive motor, and the drill head 23 is connected to the first drive shaft of the first drive motor.

[0060] The punching module 2 also includes a first switch 24, which is disposed on the first housing 21 and electrically connected to the first drive unit 22. The operator can control the start and stop of the first drive unit 22 through the first switch 24.

[0061] The drilling module 2 also includes a speed adjustment knob 25, which is located on the first housing 21 and is electrically connected to the first drive unit 22. The operator can adjust the speed of the first drive unit 22 through the speed adjustment knob 25, thereby controlling the speed of the drill bit 23.

[0062] The drilling module 2 also includes a first heat dissipation vent 26, which is disposed on the first housing 21 and / or the first driving part 22. The first heat dissipation vent 26 is used to dissipate heat inside the first housing 21 and / or the first driving part 22 to the outside in a timely manner, so as to avoid electronic component failure caused by overheating inside the first housing 21 and / or the first driving part 22. The first heat dissipation vent 26 is located on the side of the first housing 21 and / or the first driving part 22 opposite to the drill bit 23.

[0063] Among them, such as Figure 5 As shown, the drill head 23 includes a drill shaft 231 and a drill bit 232. The first end of the drill shaft 231 is connected to the drive end of the first drive unit 22, and the drill bit 232 is detachably mounted on the second end of the drill shaft 231. The second end of the drill shaft 231 has a recessed hole 233, and the drill bit 232 is inserted into the recessed hole 233 and connected to the drill shaft 231. Since the target sample 10 belongs to different types of packaging materials, during the drilling process, a corresponding drill bit 232 is required for each type of packaging material. By detachably mounting the drill bit 232 on the drill shaft 231, the drill bit 232 can be replaced to adapt to the drilling needs of different types of packaging materials, thus expanding the applicability of the drilling module 2.

[0064] In one alternative implementation, such as Figure 6 to Figure 10As shown, the implantation module 3 includes a mounting base 31, a delivery channel 32, and a delivery assembly. The delivery channel 32 is mounted on the mounting base 31 and is used to deliver the microtube 36. When the implantation module 3 is in the processing position of the target sample 10, the delivery port 321 of the delivery channel 32 is opposite to the hole 101. The delivery assembly is mounted on the mounting base 31 and is used to move the microtube 36 located in the delivery channel 32 to the delivery port 321 and implant it into the hole 101 of the target sample 10. The microtube 36 can move within the delivery channel 32.

[0065] In order to enable the microtube 36 to move within the delivery channel 32, a delivery component is provided on the mounting base 31, which can provide kinetic energy for the movement of the microtube 36.

[0066] Specifically, such as Figure 10 As shown, under the action of the delivery component, the microtube 36 can be delivered through the delivery port 321. When the implantation module 3 is in the processing position of the target sample 10, the delivery port 321 is aligned with the hole 101 of the target sample 10, that is, the delivery channel 32, the delivery port 321 and the hole 101 are coaxially arranged, and the microtube 36 will enter the hole 101 of the target sample 10 through the delivery port 321 to complete the implantation of the microtube 36.

[0067] It should be noted that the delivery channel 32 is a straight channel, which allows the microtube 36 to move smoothly within the straight channel, reducing the resistance during the delivery process of the microtube 36 and preventing damage to the microtube 36 during delivery.

[0068] In one alternative implementation, such as Figure 9 As shown, the delivery channel 32 includes a delivery groove 322 with a top opening. The delivery assembly includes a delivery wheel 33, the wheel surface of which can contact the microtube 36, and the delivery wheel 33 rotates relative to the mounting base 31 to drive the microtube 36 to move within the delivery groove 322.

[0069] In this embodiment, the delivery channel 32 includes a delivery groove 322, the top of which is open. When the microtube 36 is in the delivery groove 322, the operator can observe the movement state of the microtube 36 through the top opening of the delivery groove 322, thus realizing the visualization of the movement process of the microtube 36.

[0070] The conveying assembly includes a conveying wheel 33, which is rotatably mounted on a mounting base 31. The wheel surface of the conveying wheel 33 contacts the microtube 36 located in the delivery groove 322. When the conveying wheel 33 rotates, it can drive the microtube 36 to move along the delivery groove 322 toward the target sample 10.

[0071] When the microtube 36 is placed in the microtube groove 322, a part of the microtube 36 protrudes from the microtube groove 322, so that the conveying wheel 33 is in contact with the microtube 36.

[0072] The conveying wheel 33 is provided with a positioning groove 333 on the wheel surface, and the positioning groove 333 is arranged on the wheel surface along the circumferential direction of the conveying wheel 33, that is, the positioning groove 333 is an annular groove. The part of the microtube 36 protruding from the microtube groove 322 cooperates with the positioning groove 333, so that the conveying wheel 33 drives the microtube 36 to move.

[0073] In an alternative embodiment, as shown in Figure 6 and Figure 9 The tube implanting module 3 comprises a fixing pressing plate 34 movably arranged on the mounting seat 31, and the fixing pressing plate 34 has a pressing position and a releasing position. When the fixing pressing plate 34 is in the pressing position, the fixing pressing plate 34 is arranged on the microtube 36 in the microtube groove 322, and when the fixing pressing plate 34 is in the releasing position, the fixing pressing plate 34 is away from the microtube groove 322.

[0074] In this embodiment, the fixing pressing plate 34 is movably arranged on the mounting seat 31, and the fixing pressing plate 34 has a pressing position and a releasing position. The fixing pressing plate 34 can be switched between the pressing position and the releasing position. When the microtube 36 moves along the microtube groove 322, the fixing pressing plate 34 is arranged on the microtube 36, so as to ensure the position stability of the microtube 36 and avoid the microtube 36 from being pulled out of the microtube channel 32.

[0075] It should be noted that the pressing force of the fixing pressing plate 34 on the microtube 36 is small, and the pressing force is only used to limit the microtube 36 from being pulled out of the microtube channel 32, and will not affect the driving effect of the conveying wheel 33 on the microtube 36, and will not affect the movement of the microtube 36 along the microtube channel 32 towards the target sample 10.

[0076] In an alternative embodiment, as shown in Figure 7 , Figure 8 and Figure 10 The tube implanting module 3 comprises a positioning tube 35 arranged on the mounting seat 31, and the positioning tube 35 is in communication with the microtube port 321. The microtube 36 moves to the hole 101 through the microtube channel 32 and the positioning tube 35.

[0077] In this embodiment, the positioning tube 35 is provided on the side of the mounting base 31 close to the target sample 10, and is in communication with the delivery tube channel 32, thereby forming a complete microtube 36 movement channel. The microtube 36 passes through the delivery tube channel 32, the delivery tube port 321, and enters the positioning tube 35, which can be aligned with the hole 101 of the target sample 10. The positioning tube 35 can extend into the hole 101, so that the microtube 36 can be accurately delivered into the hole 101, and the tip of the microtube 36 is protected from collision between the tip of the microtube 36 and the target sample 10, which can effectively reduce the damage to the tip of the microtube 36.

[0078] In an alternative embodiment, as shown in Figure 7 , Figure 8 the inner diameter of the positioning tube 35 gradually decreases in the direction away from the delivery tube channel 32.

[0079] In this embodiment, the inner diameter of the positioning tube 35 gradually decreases in the direction away from the delivery tube channel 32, i.e. the movement direction of the microtube 36 in the delivery tube channel 32.

[0080] The tip of the positioning tube 35 is small in size, so that the tip of the positioning tube 35 can be easily connected with the hole 101 to form a channel, and the microtube 36 can be protected from collision during tube implantation, and the tip of the microtube 36 can be prevented from breaking. It is conceivable that although the inner diameter of the positioning tube 35 gradually decreases, the size of the tip of the positioning tube 35 is still greater than the size of the microtube 36, so that the microtube 36 can be smoothly moved into the hole 101, and the resistance during tube implantation can be minimized.

[0081] In an alternative embodiment, as shown in Figure 7 , Figure 8 and Figure 10 the positioning tube 35 includes a tube body 351 and a flexible body 352, the tube body 351 is arranged on the mounting base 31, and one end of the tube body 351 is in communication with the delivery tube port 321. The flexible body 352 is arranged at the other end of the tube body 351, and can be in contact with the hole wall of the hole 101.

[0082] In this embodiment, the positioning tube 35 includes a tube body 351 and a flexible body 352, the tube body 351 is connected to the mounting base 31, one end of the tube body 351 is in communication with the delivery tube port 321, and the other end of the tube body 351 is provided with the flexible body 352. The flexible body 352 is used to contact the hole 101 of the target sample 10, and can provide a certain buffer space. When the microtube 36 is delivered into the hole 101 through the positioning tube 35, the flexible body 352 can protect the tip of the microtube 36 from being broken by a rigid collision.

[0083] In an alternative embodiment, as shown in Figure 7 andFigure 8 As shown, the flexible body 352 includes multiple positioning ribs 3521 and connecting ribs 3522. The multiple positioning ribs 3521 are spaced apart and connected to the other end of the tube body 351. The free ends of the positioning ribs 3521 can extend into the holes 101. The connecting ribs 3522 are connected to the multiple positioning ribs 3521 and are arranged close to the tube body 351.

[0084] In this embodiment, the flexible body 352 includes a plurality of positioning ribs 3521 and connecting ribs 3522. The positioning ribs 3521 are spaced apart and connected to the other end of the tube body 351, with the tips of the positioning ribs 3521 approaching each other, causing the inner diameter of the flexible body 352 to gradually decrease. The connecting ribs 3522 are connected to the plurality of positioning ribs 3521 respectively, which can improve the connection stability of the connecting ribs 3522. Specifically, the connecting ribs 3522 are annular ribs.

[0085] The number of positioning ribs 3521 is 3, 4, 5, 6, 7, or 8. Multiple positioning ribs 3521 are evenly spaced and connected to the pipe body 351. Each positioning rib 3521 includes a first end connected to the pipe body 351 and a second end away from the pipe body 351, such as... Figure 8 As shown, the thickness of the second end of the positioning rib 3521 is less than the thickness of the first end of the positioning rib 3521. That is, along the direction away from the delivery channel 32, the thickness of the positioning rib 3521 gradually decreases, which makes it convenient for the second end of the positioning rib 3521 to extend into the hole 101 of the target sample 10.

[0086] It should be noted that, secondly, the implantation module 3 provided in this application can be used independently as a separate embodiment. It is used to implant microtubes 36 into the pores 101 of the target sample 10 during the preparation of a positive control. The implantation module 3 includes a mounting base 31, a delivery channel 32, and a delivery assembly. The delivery channel 32 is disposed on the mounting base 31 and is used to deliver the microtubes 36. The delivery port 321 of the delivery channel 32 is positioned opposite the pores 101 on the target sample 10. The delivery assembly is disposed on the mounting base 31 and is used to transfer the microtubes 36 located within the delivery channel 32 to the delivery port 321 and implant them into the pores 101 of the target sample 10.

[0087] The implantation module 3, which is an independent embodiment, also includes other structures included in the implantation module 3 in any of the above embodiments, which will not be described in detail here.

[0088] In one alternative implementation, such as Figure 1 , Figure 2 and Figure 11 As shown, the processing module also includes a dust removal module 4, which can perform dust removal on the target sample 10 to remove residual dust in the holes 101.

[0089] In the process of processing the target sample 10, the target sample 10 is first punched to form a hole 101 on the target sample 10. In the process of punching, debris and dust will be generated. When the target sample 10 is an eye drop bottle, in addition to dust, the drug liquid may also overflow during the punching process. The dust removal module 4 can blow dry the overflowed drug liquid.

[0090] In this embodiment, the dust removal module 4 removes the dust, overflowed drug liquid, etc. to clean the hole 101 of the target sample 10, avoiding interference with the subsequent processing process.

[0091] In an alternative embodiment, as shown in Figure 11 The dust removal module 4 includes a second housing 41, a plasma generator 42, and an air outlet pipe 43. The plasma generator 42 is connected to the second housing 41. The air outlet pipe 43 is connected to the plasma generator 42, and the air outlet pipe 43 can transport the plasma wind generated by the plasma generator 42 to the hole 101 of the target sample 10.

[0092] In this embodiment, the dust removal module 4 includes a second housing 41, a plasma generator 42, and an air outlet pipe 43. The second housing 41 is used to install the plasma generator 42. After the plasma generator 42 is started, plasma wind can be generated. The plasma wind is transported to the hole 101 of the target sample 10 through the air outlet pipe 43, so that the dust, overflowed drug liquid, and other substances at the hole 101 are removed.

[0093] The dust removal module 4 further includes a second switch 44. The second switch 44 is arranged on the second housing 41 and is electrically connected to the plasma generator 42. The second switch 44 is used to control the opening or closing of the plasma generator 42.

[0094] The dust removal module 4 further includes a temperature adjustment knob 45. The temperature adjustment knob 45 is used to control the temperature of the plasma gas generated by the plasma generator 42.

[0095] The dust removal module 4 further includes a wind speed adjustment knob 46. The wind speed adjustment knob 46 is used to control the speed of the plasma gas generated by the plasma generator 42.

[0096] The dust removal module 4 further includes a generation amount control knob 47. The generation amount control knob 47 is used to control the corresponding plasma generation amount of the plasma generator 42.

[0097] The dust removal module 4 further includes a display screen 48. The display screen 48 is used to display the working parameters of the plasma generator 42.

[0098] The dust removal module 4 further comprises a second heat dissipation port 49 arranged on the plasma generator 42 and / or the second shell 41, for timely dissipating heat to the outside to avoid overheating of the dust removal module 4 and possible failure. The second heat dissipation port 49 is arranged on the side of the second shell 41 / plasma generator 42 away from the drill bit 23.

[0099] In an alternative embodiment, as shown in Figure 1 , Figure 2 and Figure 12 , the processing module further comprises a solidification module 5 capable of performing solidification treatment on the target sample 10 to solidify the microtubes 36 in the pores 101.

[0100] In this embodiment, the processing module further comprises a solidification module 5, which performs solidification treatment on the pores 101 of the target sample 10 after the microtubes 36 are implanted in the pores 101 of the target sample 10 to prevent the microtubes 36 from being pulled out of the pores 101.

[0101] It is worth noting that during the solidification treatment, a solidification medium needs to be applied to the pores 101 of the target sample 10. During the solidification treatment, the solidification medium changes from one state to another, and the solidification medium undergoes chemical or physical changes, eventually forming a hard and stable structure. For example, the solidification medium is a photocuring medium, which changes state under the action of light.

[0102] In an alternative embodiment, as shown in Figure 12 , the solidification module 5 comprises an ultraviolet generator 51, and the pores 101 of the target sample 10 are located within the ultraviolet range of the ultraviolet generator 51.

[0103] In this embodiment, the solidification module 5 comprises an ultraviolet generator 51, and the solidification medium comprises a photosensitive resin. After the microtubes 36 are implanted in the pores 101, the photosensitive resin is applied to the position between the pore wall of the pore 101 and the microtube 36. Since the photosensitive resin is within the ultraviolet range of the ultraviolet generator 51, the photosensitive resin is cured under the action of ultraviolet light, achieving encapsulation of the pores 101 of the target sample 10.

[0104] The solidification medium comprises an epoxy resin.

[0105] The ultraviolet generator 51 comprises a plurality of ultraviolet light sources 52 arranged at intervals, and the light-emitting ends of each ultraviolet light source 52 are close to each other. The plurality of ultraviolet light sources 52 simultaneously perform solidification treatment on the target sample 10, which can shorten the time required for solidification treatment. The number of ultraviolet light sources 52 includes 2, 3, 4, etc.

[0106] In an alternative embodiment, as shown in Figure 1 ,Figure 2 and Figure 13 As shown, the processing module also includes a tube cutting module 6, which can cut the target sample 10 to adjust the length of the microtube 36 after curing.

[0107] In this embodiment, the processing module also includes a tube cutting module 6, which is used to adjust the length of the cured microtubes 36 so that the outer contour surface of the target sample 10 is flat and there are no protruding microtubes 36, which facilitates subsequent transportation and other processing.

[0108] In one alternative implementation, such as Figure 13 As shown, the tube cutting module 6 includes a third housing 61, a second drive unit 62, and a cutting unit 63. The second drive unit 62 is connected to the third housing 61. The cutting unit 63 is disposed on the drive end of the second drive unit 62, and the second drive unit 62 can drive the cutting unit 63 to rotate to cut the solidified microtubes 36.

[0109] In this embodiment, the third housing 61 is used to mount the second drive unit 62. The cutting unit 63 is connected to the drive end of the second drive unit 62. After the second drive unit 62 is started, the drive end can drive the cutting unit 63 to rotate relative to the third housing 61, thereby realizing the cutting operation of the cutting unit 63 on the microtube 36.

[0110] The second drive unit 62 includes a second drive motor, and the cutting unit 63 is connected to the second drive shaft of the second drive motor. The cutting unit 63 includes a cutting blade, which is connected to the second drive shaft and moves synchronously with the second drive shaft.

[0111] The pipe cutting module 6 also includes a pipe cutting switch, which is mounted on the third housing 61 and is electrically connected to the second drive unit 62. The pipe cutting switch is used to control the start and stop of the second drive unit 62.

[0112] It should be noted that, considering that the microtube 36 is made of glass and glass has a high rigidity, when the cured microtube 36 is cut by the cutting part 63, the cutting part 63 can be controlled to cut the microtube 36 once or twice to form a cut on the microtube 36. The operator can then break the microtube 36, minimizing the number of cuts and reducing the generation of debris during the cutting process, thus avoiding the impact of debris on the quality of the positive control.

[0113] In one alternative implementation, such as Figure 13 As shown, the pipe cutting module 6 also includes a collection groove 64, the opening of which is located below the cutting section 63.

[0114] In this embodiment, a collecting groove 64 is arranged below the cutting part 63. The debris generated during the cutting process falls into the collecting groove 64 through the groove opening under the action of gravity, ensuring that the debris generated during the preparation process is effectively collected, avoiding the debris from splashing everywhere to pollute and affect the normal work of other processing modules.

[0115] The inner surface of the collecting groove 64 is provided with an anti-static coating. The anti-static coating is used to reduce the accumulation of static electricity during the collection of the microtubule 36, prevent static discharge, safely dissipate the electric charge, and avoid triggering electric shock, sparks, and other dangers during the preparation of the positive control sample. Specifically, the anti-static coating is made of a conductive material.

[0116] In an alternative embodiment, as shown in Figure 14 The clamping assembly 1 includes a first clamping arm 11 and a second clamping arm 12. The second clamping arm 12 is movable relative to the first clamping arm 11 to clamp the target sample 10 between the first clamping arm 11 and the second clamping arm 12.

[0117] In this embodiment, the clamping assembly 1 is used to clamp the target sample 10. The clamping assembly 1 includes two clamping arms, i.e., the first clamping arm 11 and the second clamping arm 12. The first clamping arm 11 is a fixed clamping arm, and the second clamping arm 12 is a movable clamping arm. The second clamping arm 12 is movable relative to the first clamping arm 11, so that the clamping space between the first clamping arm 11 and the second clamping arm 12 is adjustable.

[0118] On the one hand, different types of target samples 10 require different clamping spaces. On the other hand, a certain installation space is required during the installation of the target sample 10 on the clamping assembly 1. In this embodiment, the second clamping arm 12 is movably arranged relative to the first clamping arm 11, so that the installation of the target sample 10 is facilitated, and the clamping requirements of different types of target samples 10 can be met, thereby improving the versatility of the preparation device.

[0119] In an alternative embodiment, as shown in Figure 14 The clamping assembly 1 further includes a clamping seat 13, an avoiding hole, a connecting rod 14, and a fastener 15. The first clamping arm 11 and the second clamping arm 12 are arranged on the clamping seat 13. The avoiding hole is arranged on the second clamping arm 12. The connecting rod 14 is connected to the first clamping arm 11 through the avoiding hole. The fastener 15 is connected to the connecting rod 14 and located on the side of the second clamping arm 12 away from the first clamping arm 11.

[0120] In this embodiment, the clamping assembly 1 further includes a clamping seat 13. The clamping seat 13 is used to install the first clamping arm 11 and the second clamping arm 12, thereby realizing the modular assembly of the clamping assembly 1. The first clamping arm 11 is fixedly installed on the clamping seat 13, and the second clamping arm 12 is movably installed on the clamping seat 13. The second clamping arm 12 is provided with an avoiding hole. The connecting rod 14 is connected to the first clamping arm 11 after passing through the avoiding hole.

[0121] Wherein, after the target sample 10 is placed between the first clamping arm 11 and the second clamping arm 12, the second clamping arm 12 is moved to clamp the target sample 10 with the first clamping arm 11, and then the fastener 15 on the connecting rod 14 is tightened to stabilize the position of the second clamping arm 12 and the target sample 10.

[0122] Wherein, the number of the avoidance hole, the connecting rod 14 and the fastener 15 is one-to-one. Optionally, the number of the avoidance hole, the connecting rod 14 and the fastener 15 is two.

[0123] In an optional embodiment, as shown in Figure 1 、 Figure 2 and Figure 15 The preparation device further comprises a plurality of adjustment modules 7, each of which is connected to a plurality of processing modules, and is used to adjust the to-be-processed position of the target sample 10 clamped by the clamping assembly 1 when the processing module is in the processing position of the corresponding clamping assembly 1.

[0124] In this embodiment, the preparation device further comprises a plurality of adjustment modules 7, which are arranged one-to-one with the plurality of processing modules, and each processing module is installed at the to-be-installed position through an adjustment module 7. When the processing module is in the processing position of the target sample 10, the adjustment module 7 can be used to adjust the to-be-processed position of the target sample 10.

[0125] It should be noted that for each target sample 10, the processing position thereof refers to the position directly opposite to the target sample 10, and the relative movement between the processing module and the clamping assembly 1 is used to realize that the processing module is in the processing position, so that the processing module can process the target sample 10.

[0126] Meanwhile, for each target sample 10, the to-be-processed position thereof refers to the specific position of the target sample 10 that needs to be processed, and the adjustment module 7 can finely adjust the processing posture of the processing module, so that the processing module can be aligned with the to-be-processed position of the target sample 10 to realize accurate processing.

[0127] Specifically, the punching module 2 is installed on the adjustment module 7, and under the action of the adjustment module 7, the punching module 2 can move in the direction of approaching or moving away from the target sample 10, adjust the position of the drill bit 232, and align the punching position and the punching depth of the target sample 10.

[0128] Specifically, the implanting module 3 is installed on the adjusting module 7, and under the action of the adjusting module 7, the implanting module 3 can move along the direction of approaching or moving away from the target sample 10. Before the microtube 36 is implanted, the implanting module 3 is controlled to move along the direction of approaching the target sample 10 by the adjusting module 7, so that the positioning tube 35 of the implanting module 3 extends into the hole 101 of the target sample 10. Then, the conveying wheel 33 is controlled to rotate, so that the conveying wheel 33 drives the microtube 36 to move along the conveying channel 32, and the microtube 36 is conveyed to the hole 101 through the conveying port 321 and the positioning tube 35. Finally, the implanting module 3 is controlled to move along the direction of moving away from the target sample 10 by the adjusting module 7, so that the microtube 36 is separated from the implanting module 3, and the implanting process is completed.

[0129] Specifically, the implanting module 3 is installed on the adjusting module 7, and under the action of the adjusting module 7, the implanting module 3 can move along the direction of approaching or moving away from the target sample 10. Before the microtube 36 is implanted, the implanting module 3 is controlled to move along the direction of approaching the target sample 10 by the adjusting module 7, so that the positioning tube 35 of the implanting module 3 extends into the hole 101 of the target sample 10. Then, the conveying wheel 33 is controlled to rotate, so that the conveying wheel 33 drives the microtube 36 to move along the conveying channel 32, and the microtube 36 is conveyed to the hole 101 through the conveying port 321 and the positioning tube 35. Finally, the implanting module 3 is controlled to move along the direction of moving away from the target sample 10 by the adjusting module 7, so that the microtube 36 is separated from the implanting module 3, and the implanting process is completed.

[0130] Specifically, the implanting module 3 is installed on the adjusting module 7, and under the action of the adjusting module 7, the implanting module 3 can move along the direction of approaching or moving away from the target sample 10. Before the microtube 36 is implanted, the implanting module 3 is controlled to move along the direction of approaching the target sample 10 by the adjusting module 7, so that the positioning tube 35 of the implanting module 3 extends into the hole 101 of the target sample 10. Then, the conveying wheel 33 is controlled to rotate, so that the conveying wheel 33 drives the microtube 36 to move along the conveying channel 32, and the microtube 36 is conveyed to the hole 101 through the conveying port 321 and the positioning tube 35. Finally, the implanting module 3 is controlled to move along the direction of moving away from the target sample 10 by the adjusting module 7, so that the microtube 36 is separated from the implanting module 3, and the implanting process is completed.

[0131] Specifically, the implanting module 3 is installed on the adjusting module 7, and under the action of the adjusting module 7, the implanting module 3 can move along the direction of approaching or moving away from the target sample 10. Before the microtube 36 is implanted, the implanting module 3 is controlled to move along the direction of approaching the target sample 10 by the adjusting module 7, so that the positioning tube 35 of the implanting module 3 extends into the hole 101 of the target sample 10. Then, the conveying wheel 33 is controlled to rotate, so that the conveying wheel 33 drives the microtube 36 to move along the conveying channel 32, and the microtube 36 is conveyed to the hole 101 through the conveying port 321 and the positioning tube 35. Finally, the implanting module 3 is controlled to move along the direction of moving away from the target sample 10 by the adjusting module 7, so that the microtube 36 is separated from the implanting module 3, and the implanting process is completed.

[0132] In an alternative embodiment, as shown in Figure 15 The adjusting module 7 includes a connecting column 71 and a connecting seat 72, the connecting seat 72 is rotatably installed on the connecting column 71 through a connecting shaft 73, and the processing module is arranged on the connecting seat 72. The processing module can adjust the position of the target sample 10 clamped relative to the clamping assembly 1 through the rotation of the connecting seat 72.

[0133] In this embodiment, the adjusting module 7 includes a connecting column 71 and a connecting seat 72, the connecting seat 72 is rotatably connected to the connecting column 71, and the connecting column 71 is used to be installed on the to-be-installed position. The processing module is arranged on the connecting seat 72, and when the connecting seat 72 rotates relative to the connecting column 71, the processing module can approach or move away from the target sample 10.

[0134] It is worth mentioning that the connecting seat 72 is provided with a structure matched with the processing module. For example, the connecting seat 72 is provided with a connecting groove, and a part of any one of the punching module 2, the dust removal module 4, the curing module 5 and the pipe cutting module 6 is embedded in the connecting groove. Alternatively, the connecting seat 72 is provided with a connecting surface, and the mounting seat 31 of the pipe planting module 3 is arranged on the connecting surface. It is conceivable that, in order to realize the matched connection of the connecting seat 72 and the processing module, the matched structure provided on the connecting seat 72 can also be other forms, which is not limited in the present application.

[0135] In an alternative embodiment, as shown in Figure 15 , the adjusting module 7 further comprises a rotating groove 712, a first shaft hole 711 and a second shaft hole 721. The rotating groove 712 is arranged at one end of the connecting column 71, and a part of the connecting seat 72 is located in the rotating groove 712. The first shaft hole 711 is arranged on the opposite two side walls of the connecting column 71, and the first shaft hole 711 is in communication with the rotating groove 712. The second shaft hole 721 is arranged on the connecting seat 72, and the connecting shaft 73 passes through the second shaft hole 721 and the first shaft hole 711 respectively, so that the connecting seat 72 and the connecting column 71 are rotatably connected.

[0136] In this embodiment, the adjusting module 7 further comprises a rotating groove 712, which is arranged at one end of the connecting column 71, and the other end of the connecting column 71 is used for mounting at the installation position. Specifically, the connecting column 71 comprises a top end and a bottom end, and the bottom end of the connecting column 71 is used for connecting at the installation position, and the top end of the connecting column 71 is provided with the rotating groove 712.

[0137] A part of the connecting seat 72 is located in the rotating groove 712, and the connecting shaft 73 passes through the first shaft hole 711 on the connecting column 71 and the second shaft hole 721 on the connecting seat 72 respectively, so that the connecting seat 72 and the connecting column 71 are rotatably connected. When the connecting seat 72 rotates around the connecting shaft 73, the processing module located on the connecting seat 72 will also move with the connecting seat 72. Among them, when the connecting seat 72 rotates counterclockwise around the connecting shaft 73, the processing module located on the connecting seat 72 will move towards the direction close to the target sample 10. When the connecting seat 72 rotates clockwise, the processing module will move away from the target sample 10.

[0138] In an alternative embodiment, as shown in Figure 1 , Figure 2 and Figure 16 , the preparation device further comprises a locking assembly 8, which is used to limit the relative movement of the processing module and the clamping assembly 1 when the processing module is at the processing station of the target sample 10.

[0139] In this embodiment, the preparation device further comprises a locking assembly 8, which limits the relative movement between the processing module and the clamping assembly 1 when the processing module is in the processing position, so as to provide a stable processing environment for the processing module during the processing process and avoid processing failure caused by the relative movement between the processing module and the target sample 10 during the processing process.

[0140] The locking assembly 8 comprises a magnetic locking structure, a buckle locking structure, etc.

[0141] In an alternative embodiment, as shown in Figure 16 The locking assembly 8 comprises a first locking seat 81, a plurality of second locking seats 82, and a locking part 83. The first locking seat 81 is fixedly assembled with one of the processing module or the clamping assembly 1. The plurality of second locking seats 82 are respectively fixedly assembled with the other of the processing module or the clamping assembly 1. The locking part 83 is arranged on the first locking seat 81, and the locking part 83 is selectively connected in the plurality of second locking seats 82.

[0142] In this embodiment, the locking assembly 8 comprises the first locking seat 81 with the locking part 83 and the plurality of second locking seats 82. The first locking seat 81 is arranged on one of the processing module or the clamping assembly 1, and the plurality of second locking seats 82 are arranged on the other of the processing module or the clamping assembly 1.

[0143] When the processing module is in the processing position of the target sample 10, the locking part 83 is selectively connected in the plurality of second locking seats 82.

[0144] In an alternative embodiment, as shown in Figure 16 The second locking seat 82 comprises a matching hole 821. The locking part 83 comprises a locking pin, which is movable relative to the first locking seat 81 and is inserted into the matching hole 821 to be locked when in the locking position.

[0145] In this embodiment, the second locking seat 82 is provided with the matching hole 821, and the locking part 83 comprises the locking pin, which is movable relative to the first locking seat 81 to switch between the locking position and the unlocking position.

[0146] When the processing module is in the processing position, the locking pin is in the locking position and is inserted into the matching hole 821 of the second locking seat 82 to realize the position stability between the processing module and the clamping assembly 1. When the processing process is completed, the locking pin returns to the unlocking position, i.e., the locking pin is withdrawn from the matching hole 821 and returns to the first locking seat 81, so as to release the position locking between the processing module and the clamping assembly 1.

[0147] In a possible embodiment, as shown in Figure 1 andFigure 2 As shown in FIGS. 1 and 2, the machining module and the clamping assembly 1 can rotate relative to each other or move relative to each other.

[0148] In this embodiment, the machining module and the clamping assembly 1 can rotate relative to each other, for example, the clamping assembly 1 is stationary, and the machining module rotates around the clamping assembly 1. Alternatively, the clamping assembly 1 rotates around the machining module.

[0149] In this embodiment, the machining module and the clamping assembly 1 can move relative to each other, i.e., linear motion occurs between the two, for example, the machining module and the clamping assembly 1 can move linearly relative to each other, or curve.

[0150] In an alternative embodiment, as shown in FIGS. 3 and 4, the manufacturing device further comprises a first base 91 and a second base 92, one of the clamping assembly 1 and the machining assembly is arranged on the first base 91. The other of the clamping assembly 1 and the machining assembly is arranged on the second base 92; the first base 91 and the second base 92 can move relative to each other. Figure 1 Figure 2 In this embodiment, the clamping assembly 1 and the machining assembly are respectively provided with mounting structures, which can achieve motion control of the clamping assembly 1 and the machining assembly, and the structure is simple and easy to control. Specifically, when the first base 91 and the second base 92 can move relative to each other, the first base 91 and the second base 92 drive the clamping assembly 1 and the machining assembly to move relative to each other.

[0151] In this embodiment, the clamping assembly 1 and the machining assembly are respectively provided with mounting structures, which can achieve motion control of the clamping assembly 1 and the machining assembly, and the structure is simple and easy to control. Specifically, when the first base 91 and the second base 92 can move relative to each other, the first base 91 and the second base 92 drive the clamping assembly 1 and the machining assembly to move relative to each other.

[0152] In an alternative embodiment, the number of first bases 91 is one or more, and the number of second bases 92 is one or more.

[0153] In this embodiment, the number of clamping assemblies 1 can be one or more. The machining assembly includes a plurality of machining modules. The number of first bases 91 and the number of second bases 92 are one or more, which can provide multiple choices for the installation of the clamping assembly 1 and the plurality of machining modules, so that the clamping assembly 1 and the plurality of machining modules can be arranged on a proper number of first bases 91 and second bases 92 according to actual production needs.

[0154] For example, a plurality of clamping assemblies 1 are arranged on one first base 91, and a plurality of machining modules are arranged on a plurality of second bases 92 respectively. The plurality of second bases 92 can move relative to one first base 91.

[0155] In an alternative embodiment, the second base 92 moves relative to the first base 91. That is, the first base 91 is stationary, and the second base 92 moves relative to the first base 91.

[0156] ​For example, the number of clamping assemblies 1 is one or more, which are arranged on the same or different first base 91, and a plurality of processing modules are arranged on the same or different second base 92, that is, the clamping assemblies 1 are different, and the plurality of processing modules move.

[0157] For example, the number of clamping assemblies 1 is one or more, which are arranged on the same or different second base 92, and a plurality of processing modules are arranged on the same or different first base 91, that is, the plurality of processing modules are stationary, and the clamping assemblies 1 move.

[0158] In an alternative embodiment, the preparation device further comprises a support table 94, the first base 91 and the second base 92 are arranged on the support table 94, and the assembly space 93 is formed between the first base 91 and the support table 94. The second base 92 is arranged around the first base 91 and located in the assembly space 93.

[0159] In this embodiment, the support table 94 is used to carry the first base 91 and the second base 92, the first base 91 is arranged on the support table 94, the assembly space 93 is formed between the first base 91 and the support table 94, and the second base 92 is arranged around the first base 91. The second base 92 can rotate relative to the first base 91 and the support table 94, thereby realizing the relative movement between the clamping assembly 1 and the processing module.

[0160] In an alternative embodiment, as shown in Figure 1 and Figure 2 , the first base 91 is a circular table, and the second base 92 is an annular table. The second base 92 can be sleeved outside the first base 91 and rotate relative to the first base 91.

[0161] In this embodiment, the first base 91 is a circular table, and the support table 94 is arranged at the bottom of the circular table to support the circular table. The support table 94 is provided with an annular groove 941, and the diameter of the annular groove 941 is greater than that of the circular table. The annular groove 941 is provided with a guide 95.

[0162] When the annular table is sleeved outside the circular table, the guide 95 is clamped between the annular table and the support table 94. The guide 95 can assist the annular table to rotate relative to the circular table, so that the annular table can move stably and smoothly along the annular groove 941.

[0163] In a specific embodiment, a plurality of adjustment modules 7 are arranged on the annular table, and a plurality of processing modules are connected to the top of the plurality of adjustment modules 7. The first locking seat 81 is arranged on the annular table. The plurality of processing modules include a punching module 2, a dust removal module 4, a pipe planting module 3, a solidification module 5, and a pipe cutting module 6 arranged at intervals around the circular table.

[0164] A plurality of clamping assemblies 1 are arranged on the circular table. A plurality of second locking seats 82 are arranged on the circular table. It is worth noting that the clamping assemblies 1 and the second locking seats 82 are arranged alternately on the circular table.

[0165] In a third aspect, as shown in the drawings, the application provides a preparation method of a positive control, which is implemented by the preparation device of the positive control in any of the above embodiments, and the preparation method comprises the following steps: Figure 17 S102, clamping the target sample by the clamping assembly; S104, controlling relative movement of the clamping assembly and the punching module, so that the punching module is located at a processing station of the target sample; S106, performing punching processing on the target sample by the punching module, so as to form a hole on the target sample; S108, controlling relative movement of the clamping assembly and the pipe implanting module, so that the pipe implanting module is located at the processing station of the target sample; S110, performing pipe implanting processing on the target sample by the pipe implanting module, so as to implant a micro-pipe into the hole. In the preparation method of the positive control provided by the application, the target sample is first fixed by the clamping assembly, and then the relative movement of the clamping assembly clamping the target sample and the punching module is controlled, so that the punching module is located at the processing station of the target sample. At the same time, the locking between the first locking seat and the second locking seat can be realized by the locking part on the first locking seat.

[0166] Then, the posture of the punching module is adjusted by the adjusting module, so that the drill bit of the punching module is aligned with the to-be-processed position of the target sample, the punching module is started, and a hole is formed at the to-be-processed position of the target sample. After the punching processing is completed, the locking part is unlocked.

[0167] Then, the relative movement of the clamping assembly and the pipe implanting module is controlled, so that the pipe implanting module is located at the processing station of the target sample. At this time, for the target sample, a hole has been formed at the to-be-processed position. At the same time, the locking between the first locking seat and the second locking seat can be realized by the locking part on the first locking seat.

[0168] Then, the posture of the pipe implanting module is adjusted by the adjusting module, so that the positioning pipe of the pipe implanting module is aligned with the hole of the target sample, and the position of the pipe implanting module is adjusted, so that the positioning pipe extends into the hole. The conveying assembly in the pipe implanting module is started, and the micro-pipe in the pipe conveying channel is conveyed to the outlet of the positioning pipe, that is, the micro-pipe is sent into the hole. Then, the pipe implanting module is moved away from the target sample by the adjusting module, so that the micro-pipe is separated from the pipe implanting module, and the pipe implanting processing is completed. After the pipe implanting processing is completed, the locking part is unlocked.

[0169]

[0170] ​The preparation method of the positive control provided by the application realizes the position adjustment between the processing module and the target sample by controlling the relative movement of the clamping assembly and the processing module. When the processing module is at the processing station of the target sample, the target sample is punched and the microtube is implanted by the punching module and the tube implanting module, replacing part of the manual operation, completing the microtube implantation, effectively improving the preparation speed of the positive control, enabling the supply quantity of the positive control to meet the detection needs of the leak detection machine, avoiding affecting the drug production cycle, implanting the microtube in the target sample through the tube implanting module, which can significantly reduce the number of microtube tip breakage and improve the success rate of positive control production.

[0171] In an alternative embodiment, the preparation method further comprises: controlling the relative movement of the clamping assembly and the dust removal module so that the dust removal module is located at the processing station of the target sample; performing dust removal treatment on the target sample by the dust removal module to remove residual dust in the hole.

[0172] In this embodiment, after the punching treatment of the target sample is completed by the punching module, a hole is formed on the target sample. Then the residual dust, overflowed drug solution and the like at the hole are removed by the dust removal module to clean the hole of the target sample, avoiding interference with the subsequent processing process.

[0173] Specifically, the relative movement of the dust removal module and the clamping assembly is controlled first so that the dust removal module is located at the processing station of the target sample. At the same time, the locking between the first locking seat and the second locking seat can be realized through the locking part on the first locking seat.

[0174] Then, under the action of the adjusting module, the dust removal module can be close to the target sample, so that the air outlet pipe in the dust removal module is close to the hole, thereby removing the residual dust in the hole. After the dust removal is completed, the dust removal module is moved away from the target sample by the adjusting module. After the dust removal treatment is completed, the locking part is unlocked.

[0175] In an alternative embodiment, the preparation method further comprises: controlling the relative movement of the clamping assembly and the curing module so that the curing module is located at the processing station of the target sample; performing curing treatment on the target sample by the curing module to cure the microtube in the hole.

[0176] In this embodiment, after the tube implanting treatment is completed, the target sample with the microtube is subjected to curing treatment, and the relative movement of the curing module and the clamping assembly is controlled so that the curing module is located at the processing station of the target sample. At the same time, the locking between the first locking seat and the second locking seat can be realized through the locking part on the first locking seat.

[0177] Under the action of the adjusting module, the control solidification module can move in the direction of approaching the target sample. During the solidification process, the solidification module can approach the target sample, so that the ultraviolet generator in the solidification module approaches and aligns with the hole, so that the ultraviolet light is concentrated to irradiate the solidification medium between the hole wall of the hole and the microtube, so as to realize rapid solidification and rapid fixation of the microtube. After the solidification is completed, the solidification module is moved away from the target sample by the adjusting module, and finally slowly retreats to the original position of the solidification module, and then the locking part is unlocked.

[0178] In an optional embodiment, the preparation method further comprises: The clamping assembly and the pipe cutting module are controlled to move relatively, so that the pipe cutting module is located at the processing station of the target sample. The target sample is subjected to pipe cutting treatment by the pipe cutting module, so as to adjust the length of the microtube after the solidification treatment.

[0179] In this embodiment, after the solidification treatment is completed, the microtube after the solidification treatment is subjected to pipe cutting treatment. The pipe cutting module moves relatively with the clamping assembly, so that the pipe cutting module is located at the processing station of the target sample. At the same time, the locking between the first locking seat and the second locking seat can be realized by the locking part on the first locking seat.

[0180] Under the action of the adjusting module, the pipe cutting module approaches the target sample, the cutting part in the pipe cutting module starts and contacts the remaining microtube, so as to realize the adjustment of the pipe cutting length. After the pipe cutting treatment is completed, the pipe cutting module is moved away from the target sample by the adjusting module, and then the locking part is unlocked.

[0181] For the preparation of the positive control, the punching treatment, the dust removal treatment, the pipe planting treatment, the solidification treatment and the pipe cutting treatment are performed according to the procedures. After the pipe cutting treatment is completed, the target sample with the microtube can be taken off from the clamping assembly and placed in the transfer box.

[0182] In the description of the present application, it should be understood that the terms "first", "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first", "second" can be explicitly or implicitly included one or more of the features. In the description of the present application, the meaning of "a plurality of" is two or more, unless otherwise specifically limited.

[0183] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0184] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first and second features are in direct contact, or that they are in indirect contact through an intermediate medium. Furthermore, "above," "over," or "on top" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," or "beneath" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0185] In the description of this specification, the terms "one embodiment," "some embodiments," "embodiment," "exemplary embodiment," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0186] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make modifications, alterations, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. An apparatus for preparing a positive control, characterized in that, include: Clamping assembly (1) for clamping target sample (10); The processing assembly includes multiple processing modules, each of which is movable relative to the clamping assembly (1). When a processing module is positioned at a processing station corresponding to the clamping assembly (1) on the target sample (10), the processing module processes the target sample (10); wherein, The plurality of processing modules include: The punching module (2) is capable of punching the target sample (10) to form holes (101) in the target sample (10). The tube implantation module (3) is capable of performing tube implantation on the target sample (10) to implant microtubes (36) into the hole (101).

2. The apparatus for preparing a positive control according to claim 1, characterized in that, The punching module (2) includes: First shell (21); The first drive unit (22) is connected to the first housing (21); The drill bit (23) is disposed on the drive end of the first drive unit (22), which can drive the drill bit (23) to rotate relative to the first housing (21) to form the hole (101) on the target sample (10).

3. The apparatus for preparing a positive control according to claim 1, characterized in that, The implantation module (3) includes: Mounting bracket (31); The delivery channel (32) is provided on the mounting base (31). The delivery channel (32) is used to deliver microtubes (36). When the implantation module (3) is in the processing position of the target sample (10), the delivery port (321) of the delivery channel (32) is opposite to the hole (101). A delivery assembly is provided on the mounting base (31) for transferring a microtube (36) located in the delivery channel (32) to the delivery port (321).

4. The apparatus for preparing a positive control according to claim 1, characterized in that, The processing module also includes: The dust removal module (4) is capable of performing dust removal treatment on the target sample (10) to remove residual dust inside the pores (101); and / or The curing module (5) is capable of curing the target sample (10) to solidify the microtube (36) within the pore (101); and / or The tube cutting module (6) can cut the target sample (10) to adjust the length of the microtube (36) after curing.

5. The apparatus for preparing a positive control according to claim 1, characterized in that, The clamping assembly (1) includes: First clamping arm (11); The second clamping arm (12) is movable relative to the first clamping arm (11) to clamp the target sample (10) between the first clamping arm (11) and the second clamping arm (12).

6. The apparatus for preparing a positive control according to any one of claims 1 to 5, characterized in that, The preparation apparatus further includes: Multiple adjustment modules (7) are respectively connected to multiple processing modules, and are used to adjust the processing module to align the processing module with the target sample (10) held by the clamping component (1) when the processing module is in the processing position of the corresponding clamping component (1).

7. The apparatus for preparing a positive control according to any one of claims 1 to 5, characterized in that, The preparation apparatus further includes: The locking component (8) is used to restrict the relative movement between the processing module and the clamping component (1) when the processing module is in the processing position of the target sample (10).

8. The apparatus for preparing a positive control according to any one of claims 1 to 5, characterized in that, The processing module and the clamping assembly (1) can rotate or move relative to each other.

9. A planting tube module, characterized in that, It is used in the preparation of a positive control to implant a microtube into a hole (101) in the target sample (10), the implantation module (3) comprising: Mounting bracket (31); A delivery channel (32) is provided on the mounting base (31). The delivery channel (32) is used to deliver microtubes (36). The delivery port (321) of the delivery channel (32) is used to be opposite to the hole (101) on the target sample (10). A delivery assembly is provided on the mounting base (31) for transferring a microtube (36) located in the delivery channel (32) to the delivery port (321) and implanting it into a hole (101) on the target sample (10).

10. A method for preparing a positive control, implemented using the apparatus for preparing a positive control according to any one of claims 1 to 8, characterized in that, The preparation method includes: The target sample is held by the clamping components; Control the relative movement of the clamping assembly and the drilling module so that the drilling module is positioned at the processing station of the target sample; The target sample is punched using the punching module to form holes in the target sample; Control the relative movement of the clamping assembly and the tube implantation module so that the tube implantation module is positioned at the processing station of the target sample; The target sample is treated with the implantation module to implant microtubes into the pores.

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