Novel carboxamide derivatives

By developing selective Kv7.2 enhancer compounds, the shortcomings of existing drugs in regulating Kv7.2 channels have been overcome, enabling effective treatment and prevention of related diseases, improving neural network stability, alleviating symptoms, and slowing disease progression.

CN121368581APending Publication Date: 2026-01-20ANGELINI PHARMA SPA
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Patent Information

Application Number
CN202480042158.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2023-05-09
Filing Date
2024-05-08
Publication Date
2026-01-20

AI Technical Summary

Technical Problem

Existing drugs have failed to effectively regulate the Kv7.2 channel, resulting in untreated related diseases such as epilepsy, autism, and intellectual disability. Furthermore, existing Kv7.2 modulators suffer from insufficient selectivity and pharmacological properties.

Method used

To develop Kv7.2 enhancer compounds with selective and favorable pharmacological properties to enhance the activity of Kv7.2 channels, and to prepare corresponding pharmaceutical compositions and kits for the treatment of Kv7.2-related disorders, diseases or disabilities.

Benefits of technology

By enhancing Kv7.2 channel activity, improving neural network stability, reducing abnormal neural activity, providing therapeutic and preventative treatment effects, alleviating disease symptoms, improving quality of life, and slowing disease progression.

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Abstract

The present invention provides novel dicyclopentyl compounds having the general formula (I) or solvates or pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, R5, R6, A1, A2 and X are as defined herein, compositions including these compounds, methods of making these compounds, and methods of using these compounds.
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Citation Information

Patent Citations

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