Production process of D3 calcium tablets capable of improving taste

Abstract

The invention belongs to the technical field of calcium tablet production processes, and particularly relates to a D3 calcium tablet production process capable of improving taste, which comprises the following steps: S1, mixing calcium powder, hydroxypropyl starch and water, and stirring to form mixed powder dough; s2, adding dry ice powder into the mixed dough; s3, drying the mixed powder dough containing the dry ice powder to obtain a calcium powder matrix with a porous structure; s4, segmenting the calcium powder matrix and preparing calcium tablet core particles; s5, filling micropores of the calcium tablet core particles with D3 powder to obtain D3 loaded core particles; and S6, enveloping the D3 loaded core particles to finally obtain the D3 calcium tablets. A large number of uniform three-dimensional microporous structures are formed in the D3 calcium tablet by using the sublimation characteristic of dry ice, so that the D3 calcium tablet is easy to break along a microporous interface during chewing, the chewing process is more labor-saving, and the mouthfeel is more palatable.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of calcium tablet production process, and particularly relates to a D3 calcium tablet production process for improving taste. BACKGROUND

[0002] Vitamin D3 and calcium are essential nutrients for the human body, and their synergistic effect is of great significance for maintaining bone health and promoting calcium absorption, so D3 calcium tablets have become a common nutritional supplement.

[0003] However, the existing D3 calcium tablets generally have poor taste, which is specifically manifested in that obvious grittiness and dryness are easily generated during chewing. The main reason is that in the traditional process, calcium powder particles are usually directly mixed with other auxiliary materials for tabletting, the particle size of the calcium powder is not uniformly dispersed, which easily leads to the existence of coarse and hard particles in the tablet, and the coarse taste is generated during chewing. At the same time, the calcium powder is pressed too tightly, and there is lack of fluffiness and palatability during chewing.

[0004] For children, the elderly and other people with weak swallowing function or sensitive to taste, the D3 calcium tablets with poor taste often reduce their willingness to take; at the same time, taste has become an important consideration factor for consumers to choose products, and the short board of the taste of the existing D3 calcium tablets limits the improvement of the market competitiveness of the product. Therefore, how to improve the taste of the D3 calcium tablets by optimizing the production process under the premise of ensuring the nutritional efficacy and product stability of the D3 calcium tablets has become a technical problem to be solved in the current D3 calcium tablet production field. SUMMARY

[0005] In order to solve the problems existing in the prior art, the application provides a D3 calcium tablet production process for improving taste, which utilizes the sublimation characteristics of dry ice to form a large number of uniform three-dimensional micropore structures in the D3 calcium tablet, so that the D3 calcium tablet is easily broken along the micropore interface during chewing, and the chewing process is more labor-saving and the taste is more palatable.

[0006] The specific technical scheme adopted by the application is as follows: A D3 calcium tablet production process for improving taste, comprising the following steps: S1, mixing calcium powder, hydroxypropyl starch and water to form a mixed powder mass by stirring; S2, adding dry ice powder to the mixed powder mass, and then continuing to stir to uniformly disperse the dry ice powder in the dough; S3, placing the mixed powder mass containing the dry ice powder in a negative pressure box for drying, during which the dry ice powder sublimates into gas, and uniform micropores are formed in the mixed powder mass to obtain a calcium powder matrix with a porous structure; S4, dividing the calcium powder matrix and making calcium tablet cores; S5, filling the D3 powder into the micropores of the calcium tablet core particles, and then spraying the adhesive spray to the surface of the calcium tablet core particles to form a thin adhesive layer to fix the D3 powder in the micropores, thereby obtaining D3 loaded core particles; S6, coating the D3 loaded core particles with a hydroxypropyl methyl cellulose aqueous solution as a coating liquid, and finally obtaining D3 calcium tablets.

[0007] Further, the calcium powder in step S1 is calcium carbonate powder with a particle size of 5-10 μm, and the mass ratio of the calcium powder, hydroxypropyl starch and water is 50-60:10-15:5-10.

[0008] Further, the mixed powder mass in step S1 further comprises a sugar substance and sorbitol, the sugar substance is white granulated sugar or stevia with a particle size of 5-10 μm, and the mass ratio of the calcium powder, hydroxypropyl starch, sugar substance, sorbitol and water is 50-60:10-15:2-3:1-2:5-10.

[0009] Further, the amount of dry ice powder added in step S2 is 5-8% of the total mass of the mixed powder mass, and the particle size of the dry ice powder is 0.2-0.5 mm.

[0010] Further, the pressure in the negative pressure box in step S3 is 0.06-0.07 MPa, and the drying temperature is 30-35℃.

[0011] Further, the calcium tablet core particles in step S4 are round tablet structures with a diameter of 5-8 mm.

[0012] Further, the D3 powder in step S5 is powdered cholecalciferol with a particle size of 0.01-0.03 mm.

[0013] Further, carboxymethyl starch sodium is added to the D3 powder in step S5, and the mass ratio of the D3 powder to carboxymethyl starch sodium is 90-100:2-3.

[0014] Further, the adhesive spray in step S5 is a povidone ethanol solution with a concentration of 3-5%, and the mass of the adhesive spray sprayed towards the calcium tablet core particles is 1-2% of the calcium tablet core particles.

[0015] Further, the specific steps of coating the D3 loaded core particles in step S6 are as follows: fluidized bed coating the D3 loaded core particles with a 5-8% concentration of hydroxypropyl methyl cellulose aqueous solution, setting the spray speed to 10-15 mL / min, the air inlet temperature to 35-40℃, and the air outlet temperature to 25-30℃, and finally forming D3 calcium tablets with a film layer thickness of 15-25 μm.

[0016] The beneficial effects of the present application are: 1、The dry ice is added in the mixed dough in the present application, the dry ice is sublimated into carbon dioxide gas rapidly by using the sublimation characteristics of the dry ice and escapes, and a uniform three-dimensional microporous structure is formed in the mixed dough, the porous structure causes a large number of holes to exist in the tablet, the tablet is easy to break along the microporous interface when chewed, and the dry and rough feeling caused by the tightness of the tablet in the traditional compression process is avoided, so that the chewing process is more labor-saving and the taste is more palatable.

[0017] 2、The hydroxypropyl starch in the present application is used as a core binder, the molecular chain has good flexibility and lubricity, can tightly combine calcium powder, sugar and other components to form a stable matrix, and can reduce the frictional resistance between particles, so that the surface of the tablet is smooth when chewed, and the dry and rough feeling is avoided. A small amount of sugar and sorbitol are used to improve the taste of the D3 calcium tablet, and the sorbitol and the sugar cooperate to provide a composite taste of sweetness and coolness, so as to mask the peculiar smell of the calcium tablet and make the taste of the D3 calcium tablet more rich.

[0018] 3、The porous structure of the calcium tablet core particles in the present application causes the gastric juice to quickly penetrate into the micropores after the calcium tablet enters the gastrointestinal tract, increases the contact area of the calcium powder and the digestive juice, and promotes the dissolution and absorption of the calcium carbonate; the carboxymethyl starch sodium as a disintegrating agent can accelerate the dispersion of the tablet in the gastrointestinal tract, further improve the utilization of calcium and D3, and solve the problems of slow dissolution and insufficient absorption of the traditional tight tablets.

[0019] 4、The hydroxypropyl methyl cellulose coating layer in the present application not only isolates the peculiar smell, but also blocks the external oxygen and moisture, avoids the moisture absorption and caking of the calcium powder and the oxidation and deterioration of D3, and prolongs the shelf life of the product. DETAILED DESCRIPTION

[0020] The present application will be further described below in combination with specific embodiments: I. Specific Embodiments Embodiment 1 S1, calcium powder with a particle size of 8 μm, hydroxypropyl starch, white granulated sugar, sorbitol and deionized water are mixed in a mass ratio of 55:12:2:2:8, stirred for 10 minutes by a high-speed shearing mixer with a rotation speed of 2000 rpm, and a mixed dough is formed; S2, dry ice powder with a particle size of 0.3 mm is added to the mixed dough, the amount of the dry ice powder added is 6% of the total mass of the mixed dough, and then the dry ice powder is uniformly dispersed in the dough by stirring at a rotation speed of 1500 rpm for 5 min; S3, the mixed dough containing the dry ice powder is placed in a negative pressure box for drying, the pressure in the negative pressure box is 0.06 MPa, the drying temperature is 32℃, and the drying is carried out for 1 h, during which the dry ice powder is sublimated into gas, and a uniform micropore is formed in the mixed dough, and a porous calcium powder matrix is obtained; S4, the calcium powder matrix is divided and made into calcium tablet core particles with a diameter of 6 mm. S5, the D3 powder with a particle size of 0.02 mm is mixed with carboxymethyl starch sodium according to a mass ratio of 95:2 to obtain a mixed powder, the mixed powder and the calcium tablet core particles are placed in a mixer to mix, the mixed powder is filled into the micropores, then a povidone ethanol solution with a concentration of 4% is sprayed onto the surface of the calcium tablet core particles to form a thin adhesive layer to fix the mixed powder in the micropores, and a D3 loaded core particle is obtained; S6, the D3 loaded core particle is coated by a fluidized bed coating with a 6% hydroxypropyl methyl cellulose aqueous solution, a spraying speed of 12 mL / min, an air inlet temperature of 38°C, and an air outlet temperature of 28°C are set, and finally a D3 calcium tablet is formed.

[0021] Example 2 S1, the calcium powder with a particle size of 5 μm, hydroxypropyl starch, white granulated sugar, sorbitol, and deionized water are mixed according to a mass ratio of 50:10:2:1:5, stirred by a high-speed shearing mixer with a rotating speed of 2000 rpm for 10 minutes to form a mixed dough; S2, dry ice powder with a particle size of 0.2 mm is added to the mixed dough, the amount of the dry ice powder added is 8% of the total mass of the mixed dough, and then the mixed dough is stirred at a rotating speed of 1500 rpm for 5 min to uniformly disperse the dry ice powder in the dough; S3, the mixed dough containing the dry ice powder is placed in a negative pressure box for drying, the pressure in the negative pressure box is 0.06 MPa, the drying temperature is 30°C, and the drying is performed for 1 h, during which the dry ice powder sublimates into gas, and uniform micropores are formed in the mixed dough to obtain a calcium powder matrix with a porous structure; S4, the calcium powder matrix is divided and made into calcium tablet core particles with a diameter of 8 mm; S5, the D3 powder with a particle size of 0.02 mm is mixed with carboxymethyl starch sodium according to a mass ratio of 90:2 to obtain a mixed powder, the mixed powder and the calcium tablet core particles are placed in a mixer to mix, the mixed powder is filled into the micropores, then a povidone ethanol solution with a concentration of 3% is sprayed onto the surface of the calcium tablet core particles to form a thin adhesive layer to fix the mixed powder in the micropores, and a D3 loaded core particle is obtained; S6, the D3 loaded core particle is coated by a fluidized bed coating with a 5% hydroxypropyl methyl cellulose aqueous solution, a spraying speed of 10 mL / min, an air inlet temperature of 35°C, and an air outlet temperature of 25°C are set, and finally a D3 calcium tablet is formed.

[0022] Example 3 S1, the calcium powder with a particle size of 10 μm, hydroxypropyl starch, white granulated sugar, sorbitol, and deionized water are mixed according to a mass ratio of 60:15:3:2:10, stirred by a high-speed shearing mixer with a rotating speed of 2000 rpm for 10 minutes to form a mixed dough; S2, add dry ice powder with a particle size of 0.5 mm to the mixed powder mass, the amount of dry ice powder added is 5% of the total mass of the mixed powder mass, then stir at a speed of 1500 rpm for 5 min to make the dry ice powder uniformly dispersed in the dough; S3, place the mixed powder mass containing dry ice powder in a negative pressure box for drying, the pressure in the negative pressure box is 0.07 MPa, the drying temperature is 35℃, and the drying time is 1 h, during which the dry ice powder sublimates into gas, and uniform micropores are formed in the mixed powder mass, obtaining a calcium powder matrix with a porous structure; S4, divide the calcium powder matrix and make calcium tablet core particles with a diameter of 8 mm; S5, mix D3 powder with a particle size of 0.03 mm and carboxymethyl starch sodium according to a mass ratio of 100:3 to obtain a mixed powder, and place the mixed powder and the calcium tablet core particles in a mixer to mix, so that the mixed powder fills the micropores, then spray a povidone ethanol solution with a concentration of 5% onto the surface of the calcium tablet core particles to form a thin adhesive layer to fix the mixed powder in the micropores, and obtain D3 loaded core particles; S6, fluidized bed coating of D3 loaded core particles with a 5% concentration of hydroxypropyl methyl cellulose aqueous solution, set the spray speed to 15 mL / min, the inlet air temperature to 40℃, and the outlet air temperature to 30℃, and finally form D3 calcium tablets.

[0023] Comparative Example 1 In Comparative Example 1, D3 calcium tablets were prepared by a traditional compression process, the specific steps are as follows: S1, mix calcium powder with a particle size of 8 μm, hydroxypropyl starch, white granulated sugar, sorbitol and deionized water according to a mass ratio of 55:12:2:2:8, stir for 10 minutes by a high-speed shearing mixer with a speed of 2000 rpm, and form a mixed powder mass; S2, dry the mixed powder mass under normal pressure conditions to obtain dried particles, crush and sieve to obtain mixed particles; S3, mix D3 powder with a particle size of 0.02 mm with the mixed particles, and then press the tablets by a tablet press to obtain D3 calcium tablets.

[0024] Comparative Example 2 In Comparative Example 2, dry ice was not used to make pores, the specific steps are as follows: S1, mix calcium powder with a particle size of 8 μm, hydroxypropyl starch, white granulated sugar, sorbitol and deionized water according to a mass ratio of 55:12:2:2:8, stir for 10 minutes by a high-speed shearing mixer with a speed of 2000 rpm, and form a mixed powder mass; S2, dry the mixed powder mass in a negative pressure box, the pressure in the negative pressure box is 0.06 MPa, the drying temperature is 32℃, and the drying time is 1 h, obtaining a dense calcium powder matrix; S3, divide the calcium powder matrix and make calcium tablet core particles with a diameter of 6 mm; S4, D3 powder with a particle size of 0.02 mm was mixed with sodium carboxymethyl starch according to a mass ratio of 95:2 to obtain a mixed powder, the mixed powder and calcium tablet core particles were placed in a mixer, a 4% povidone ethanol solution was sprayed onto the surface of the calcium tablet core particles, a thin adhesive layer was formed to adhere and fix the mixed powder, and D3 loaded core particles were obtained; S5, the D3 loaded core particles were coated in a fluidized bed using a 6% hydroxypropyl methyl cellulose aqueous solution, the spray speed was set to 12 mL / min, the inlet air temperature was 38°C, and the outlet air temperature was 28°C, and finally D3 calcium tablets were formed.

[0025] II. Performance testing 1. Sensory evaluation of taste Detection method: a 15-person professional sensory evaluation team tasted D3 calcium tablets, using a 10-point scoring system (10 points for the best, 1 point for the worst); Evaluation index: grit feeling (40%), dryness feeling (35%), chewing power saving (25%), and the average score of the group was taken as the comprehensive score.

[0026] 2. Sensory evaluation of taste Detection method: a 15-person professional sensory evaluation team tasted D3 calcium tablets, using a 10-point scoring system (10 points for the best, 1 point for the worst); Evaluation index: off-flavor residue (40%), sweetness coordination (30%), and cooling sensation (30%), and the average score of the group was taken as the comprehensive score.

[0027] 3. Disintegration time Detection method: According to the fourth part of Chinese Pharmacopoeia 2020 edition 0921, using a disintegration time tester, with artificial gastric juice (pH 1.2) as the medium, the time of complete disintegration of the tablets was recorded (n=6, taking the average value).

[0028] The detection results are shown in Table 1.

[0029] In Examples 1-3, the dry ice sublimation formed a microporous structure, resulting in a large number of three-dimensional pores inside the tablets, which were easy to break along the microporous interface during chewing, significantly reducing grit feeling and dryness feeling; at the same time, the flexible molecular chain of hydroxypropyl starch reduced the friction between particles, improving palatability and chewing power saving, so the comprehensive score of sensory evaluation of taste was high; White granulated sugar and sorbitol form a complex taste, and the hydroxypropyl methyl cellulose coating layer effectively isolates the bitter and metallic taste of calcium powder, and the sweetness is coordinated with the flavor of the raw materials, so the comprehensive score of sensory evaluation of taste is high.

[0030] The tablets in Comparative Example 1 had no dry ice hole, the structure of the tablets was compact after high pressure compression, the calcium powder particles aggregated, leading to strong grit feeling, obvious dry feeling, poor palatability and chewing labor-saving, so the oral sensory evaluation was very low.

[0031] In Comparative Example 2, although the hydroxypropyl starch and the coating process were retained, the easy breaking and high loft characteristics brought by the microporous were lacking, and the comprehensive score of the oral sensory evaluation was significantly lower than that of the examples.

[0032] In addition, the porous structure in Examples 1-3 allowed the artificial gastric juice to quickly penetrate into the inside of the tablets, combined with the disintegrating effect of the carboxymethyl starch sodium, accelerated the dispersion of the tablets, and the disintegration time was only 18-22 min, significantly improving the dissolution efficiency of calcium carbonate and D3; in Comparative Examples 1-2, due to the lack of porous structure, the disintegration time was longer.

Claims

1. A process for the production of D3 calcium tablets with improved mouth feel, characterized in that, The method comprises the following steps: S1, mixing calcium powder, hydroxypropyl starch and water to form a mixed powder; S2, adding dry ice powder to the mixed powder, and then continuing to stir to uniformly disperse the dry ice powder in the dough; S3, placing the mixed powder containing dry ice powder in a negative pressure box for drying, during which the dry ice powder sublimates into gas, forming uniform micropores in the interior of the mixed powder, and obtaining a calcium powder matrix with a porous structure; S4, dividing the calcium powder matrix and making calcium tablet core particles; S5, filling D3 powder into the micropores of the calcium tablet core particles, and then spraying adhesive spray onto the surface of the calcium tablet core particles to form a thin adhesive layer to fix the D3 powder in the micropores, and obtaining D3 loaded core particles; S6, using a hydroxypropyl methyl cellulose aqueous solution as a coating liquid to coat the D3 loaded core particles, and finally obtaining D3 calcium tablets.

2. The process for producing D3 calcium tablets with improved mouthfeel according to claim 1, characterized in that, The calcium powder in step S1 is calcium carbonate powder with a particle size of 5-10 μm, and the mass ratio of calcium powder, hydroxypropyl starch and water is 50-60:10-15:5-10.

3. The process for producing D3 calcium tablet with improved mouth feel according to claim 1, wherein, The mixed powder in step S1 also includes a sugar substance and sorbitol, the sugar substance is white granulated sugar or stevia with a particle size of 5-10 μm, and the mass ratio of calcium powder, hydroxypropyl starch, sugar substance, sorbitol and water is 50-60:10-15:2-3:1-2:5-10.

4. The process for producing D3 calcium tablets with improved mouthfeel according to claim 1, characterized in that, The amount of dry ice powder added in step S2 is 5-8% of the total mass of the mixed powder, and the particle size of the dry ice powder is 0.2-0.5 mm.

5. The process for producing D3 calcium tablet with improved mouth feel as claimed in claim 1 wherein, The pressure in the negative pressure box in step S3 is 0.06-0.07 MPa, and the drying temperature is 30-35℃.

6. The process for producing D3 calcium tablet with improved mouth feel according to claim 1, wherein, The calcium tablet core particles in step S4 are round tablet structures with a diameter of 5-8 mm.

7. The process for producing D3 calcium tablet with improved mouth feel according to claim 1, wherein, The D3 powder in step S5 is powdered cholecalciferol with a particle size of 0.01-0.03 mm.

8. The process for producing D3 calcium tablet with improved mouth feel according to claim 1, wherein, Carboxymethyl starch sodium is also added to the D3 powder in step S5, and the mass ratio of D3 powder to carboxymethyl starch sodium is 90-100:2-3.

9. The process for producing D3 calcium tablet with improved mouth feel according to claim 1, wherein, The adhesive spray in step S5 is a povidone ethanol solution with a concentration of 3-5%, and the mass of the adhesive spray sprayed onto the calcium tablet core particles is 1-2% of the mass of the calcium tablet core particles.

10. The process for producing D3 calcium tablet with improved mouth feel as claimed in claim 1 wherein, The specific steps for coating the D3 loaded core particles in step S6 are as follows: using a 5-8% concentration of hydroxypropyl methyl cellulose aqueous solution to fluidized bed coat the D3 loaded core particles, setting the spray speed to 10-15 mL / min, the air inlet temperature to 35-40℃, and the air outlet temperature to 25-30℃, and finally forming D3 calcium tablets with a film layer thickness of 15-25 μm.

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