Traditional Chinese medicine external washing composition as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine external preparations, and discloses a traditional Chinese medicine external washing composition as well as a preparation method and application thereof, and the traditional Chinese medicine external washing composition comprises the following raw medicinal materials in parts by weight: 10-30 parts of physalis alkekengi, 8-25 parts of perfoliote knotweed herb and 5-20 parts of virosa rugosa. The medicinal materials are dried products and are crushed and decocted with water, and the obtained filtrate is concentrated and diluted in proportion to prepare the external lotion. When in use, the liquid medicine is warmed, and externally washes or is hydropathically applied to an affected part. The three medicines have a synergistic effect, have the comprehensive effects of clearing away heat and toxic materials, resisting inflammation and relieving itching, inhibiting bacteria and preventing infection and promoting skin repair, and can effectively relieve skin redness and swelling and itching of varicella or herpes patients, promote scabbing and falling of herpes and reduce secondary infection caused by scratching. The traditional Chinese medicine external washing composition disclosed by the invention is high in safety, good in children compliance, simple and controllable in preparation process, stable in component, suitable for popularization and application in families and medical institutions, and good in clinical value and industrialization prospect.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine external preparations, specifically to a traditional Chinese medicine external wash composition for the external care or adjunctive treatment of varicella-related skin itching and herpetic lesions, its preparation method, and its application. More specifically, this invention relates to a decoction obtained by decocting fresh branches and leaves or dried products of Physalis alkekengi, Tinospora sinensis, and Breynia fruticosa as main raw materials to relieve skin itching, redness, swelling, oozing, and herpetic lesions caused by chickenpox or herpes. Through external washing or wet compresses, it achieves a comprehensive effect of clearing heat and detoxifying, anti-inflammatory and antipruritic, promoting crusting, and preventing secondary infection. This belongs to the applied technology in the intersection of traditional Chinese medicine anti-inflammatory and antiviral and skin repair care. Background Technology

[0002] Chickenpox is an acute infectious disease caused by the varicella-zoster virus (VZV), most commonly affecting children and adolescents. The main clinical manifestations are fever and itchy blisters on the skin and mucous membranes. Initially, the contents of the blisters are clear, then become cloudy and gradually crust over. The course of the disease is about 7-10 days in most patients. Although the prognosis is generally good, secondary bacterial infections are common after the rash ruptures or is scratched, and in severe cases, scarring can occur, affecting appearance and skin function. Current clinical treatment for chickenpox mainly involves antiviral drugs and symptomatic management. Commonly used drugs include acyclovir, valacyclovir, and ribavirin. These drugs primarily work by inhibiting viral DNA synthesis, but they often require systemic administration, which presents challenges such as poor compliance in children, gastrointestinal irritation, and a heavy metabolic burden on the liver and kidneys. Meanwhile, topical skin preparations are mostly calamine lotion, antihistamine cream or corticosteroid ointment. Although they can temporarily relieve itching and inflammation, they have limited effect on promoting the drying and crusting of herpes. In addition, some patients experience adverse reactions such as skin irritation and pigmentation after using hormone drugs.

[0003] Traditional Chinese medicine (TCM) considers chickenpox to fall under the category of "damp-heat toxins manifesting on the skin," with the main pathogenesis being "damp-heat accumulating in the skin and heat toxins rising upwards." Treatment principles primarily focus on clearing heat and detoxifying, removing dampness and relieving itching, and cooling the blood to eliminate rashes. Traditional TCM external treatments often involve washing or applying decoctions of Chinese herbs to clear heat and detoxify, dispel wind and relieve itching, and promote the healing of blisters. However, most publicly available herbal washes are designed for diseases such as eczema, dermatitis, or herpes zoster, and there is a lack of specialized compositions specifically targeting the characteristics of chickenpox blisters while also relieving itching, preventing infection, and promoting scab repair. Some existing research utilizes heat-clearing and detoxifying herbs such as honeysuckle, forsythia, phellodendron, and sophora flavescens to create washes or sprays, but these formulas often have complex ingredients, weak targeting, and some components can easily cause skin irritation. Furthermore, most preparations use dried herbs, resulting in light-colored solutions with limited effective ingredient content, making it difficult to form a long-lasting protective layer on the skin. For chickenpox patients, especially children, there is an urgent need for a safe, gentle, and effective traditional Chinese medicine (TCM) external wash composition that directly targets the skin lesions and simultaneously clears heat, relieves itching, prevents infection, and promotes scab formation. Therefore, developing a TCM external wash composition using natural plant branches and leaves as raw materials, extracting a dark-colored liquid through decoction, forming a protective film on the skin surface, and promoting scab formation is of significant clinical importance and widespread application for improving skin symptoms in chickenpox patients, reducing the risk of secondary infections, and enhancing the safety of medication in children.

[0004] I. Limitations of Existing Technology

[0005] Currently, the main treatments for chickenpox, both domestically and internationally, focus on antiviral therapy, antipyretics, antipruritic measures, and prevention of secondary infections. The primary form of medication is a combination of systemic and topical applications. However, existing technologies have the following prominent problems and shortcomings:

[0006] (a) Systemic drug administration has a long course of treatment and poor compliance.

[0007] Commonly used antiviral drugs such as acyclovir and valacyclovir are mostly administered orally or intravenously. Although they can inhibit viral replication to some extent, they require continuous use for 5 to 7 days or more. Children often experience difficulties taking the medication, swallowing, and experiencing poor taste, leading to low compliance. Furthermore, some drugs are metabolized by the liver and kidneys, posing a potential burden on young children and those with weakened constitutions. Long-term or high-dose use can easily cause adverse reactions such as nausea, fatigue, and elevated liver enzymes.

[0008] (ii) Topical preparations have a single effect and unstable efficacy.

[0009] Current topical products mainly include calamine lotion, antihistamine creams, corticosteroid ointments, and antibacterial sprays. These preparations primarily aim to relieve itching and control exudation. While they can temporarily alleviate discomfort, they lack sustained protection for broken skin. Especially after herpes ruptures, the skin surface is exposed. If the medication has poor retention and weak protective film formation ability, it can easily lead to secondary infection from scratching or delayed crusting.

[0010] (iii) Some chemical or hormone preparations pose safety hazards.

[0011] Corticosteroid ointments can quickly relieve inflammation and itching, but long-term or repeated use may cause side effects such as skin atrophy, telangiectasia, and pigmentation, making them unsuitable for children and sensitive individuals. Some topical solutions containing alcohol, preservatives, or artificial colors may also cause stinging or allergic reactions during use, affecting patient compliance.

[0012] (iv) Existing traditional Chinese medicine external wash formulas lack systematic research on chickenpox.

[0013] Although traditional Chinese medicine external treatments are widely used in treating herpetic diseases, currently available herbal wash compositions are mostly used for eczema, dermatitis, or herpes zoster, and are not specifically designed for the characteristics of chickenpox rashes, such as "intense itching, significant exudation, and susceptibility to infection." Most formulas contain complex ingredients, lack clear formulation principles, and suffer from a lack of standardized decoction processes, resulting in unstable active ingredients and difficulty in ensuring consistent clinical efficacy.

[0014] (v) The liquid is light in color, has poor retention, and lacks physical barrier function.

[0015] Most existing Chinese herbal external wash preparations are made by decocting dried products, resulting in a light yellow or light brown liquid that is quickly absorbed or evaporated by the skin after use. This makes it difficult to form an effective protective layer on the skin surface and limits its astringent and protective effects on herpes lesions.

[0016] (vi) Lack of safe, gentle, and astringent natural wash compositions that can help heal scabs.

[0017] Chickenpox patients, especially children, have high requirements for the irritation and safety of topical medications. There are currently no topical washes on the market that use natural fresh branches and leaves as raw materials, form a natural medicinal film on the skin after decoction, and can both relieve itching and promote scab formation.

[0018] In summary, existing technologies generally suffer from problems such as limited efficacy, insufficient safety, unstable ingredients, and poor user compliance. There is a lack of a traditional Chinese medicine external wash composition that simultaneously possesses the functions of clearing heat and detoxifying, anti-inflammatory and antipruritic, preventing infection, and promoting scab repair. Therefore, developing an innovative external wash preparation using fresh branches and leaves of natural medicinal materials, capable of producing a dark-colored decoction that forms a protective film on the skin surface, has become an urgent need to address the inadequacies of external treatments for chickenpox.

[0019] II. Theoretical Basis of Traditional Medicine

[0020] According to the theory of syndrome differentiation and treatment in Traditional Chinese Medicine (TCM), chickenpox falls under the category of "damp-heat toxins manifesting on the skin," similar to diseases such as "epidemic sores," "herpes," and "heat-toxin sores" in the *Treatise on the Causes and Symptoms of Various Diseases*. TCM believes its main pathogenesis is "invasion of wind-heat toxins, which accumulate in the skin, internally transforming into fire, and manifesting as herpes," with the lesions located between the skin and the lung and spleen meridians. Treatment should focus on clearing heat and detoxifying, removing dampness and relieving itching, cooling the blood and eliminating rashes, allowing the heat toxins to be released, the damp-heat to clear, and the herpes to heal naturally.

[0021] Chickenpox initially presents with symptoms such as fever, rash, itching, and sore throat, indicating an invasion of wind-heat toxins into the skin surface and heat in the Qi level. Treatment should focus on clearing heat and promoting rash eruption, cooling the blood, and detoxifying. When blisters rupture, ooze fluid, or become infected, it indicates damp-heat accumulation in the skin and stagnation of toxic heat, requiring treatment to clear heat, dry dampness, detoxify, and promote wound healing. Traditional Chinese medicine external treatments believe that external washing with medicinal solutions can "directly reach the affected area, clear the pores, and quickly expel heat toxins." Through local action, it achieves the purpose of clearing heat and removing dampness, reducing swelling, and relieving itching. It is more effective and safer than oral medications, and is especially suitable for children and people with weak constitutions.

[0022] In historical medical texts and folk remedies, *Physalis alkekengi*, *Polygonum cuspidatum*, and *Citrus aurantium* are all commonly used heat-clearing and detoxifying herbs in Lingnan. The combination of these three herbs exhibits a synergistic effect.

[0023] 1. Physalis alkekengi

[0024] It is bitter and cold in nature, entering the lung and kidney meridians. Its functions include clearing heat and detoxifying, relieving sore throat and swelling, and moistening the lungs and relieving cough. The *Compendium of Materia Medica* records that it "treats sore throat, clears heat toxins, and heals sores." In folk medicine, fresh leaves are often decocted and used externally to wash various heat-related sores and rashes. Modern research shows that *Physalis alkekengi* contains physalin, solanine, and flavonoids, which have anti-inflammatory, antiviral, and skin-repairing effects, effectively reducing redness and pain from chickenpox blisters.

[0025] 2. Tinospora sinensis

[0026] It has a bitter taste and cold nature, entering the liver and stomach meridians. Its functions include clearing heat and detoxifying, reducing swelling and relieving pain. The *Guangxi Materia Medica* records that it "treats carbuncles, boils, and sore throats," making it one of the commonly used heat-clearing and detoxifying herbs in southern China. Modern pharmacological studies have shown that *Polygonum multiflorum* contains alkaloids and diterpenoids, which significantly inhibit the expression of inflammatory factors and regulate immune responses, thus alleviating local inflammation caused by chickenpox and promoting herpes healing.

[0027] 3. White Rice Fruit (Breynia fruticosa)

[0028] It is neutral in nature and sweet in taste, entering the lung and stomach meridians. Its functions include clearing heat and dampness, detoxifying and stopping diarrhea. The *Southern Herbal Records* states that it "treats damp-heat diarrhea, sores, scabies, mouth ulcers, and sore throat." In folk medicine, its leaves are often decocted for bathing infants with eczema and prickly heat. Modern research shows that *Prunus japonica* contains flavonoids, polyphenols, and saponins, which have antibacterial, anti-inflammatory, antioxidant, and epithelial regeneration-promoting effects.

[0029] When used together, the three herbs complement each other: Physalis alkekengi is the principal herb, mainly used to clear heat and detoxify, reduce swelling and relieve pain;

[0030] The herb *Polygonum hydropiper* is used as the assistant herb, helping to clear heat, cool the blood, detoxify, and reduce inflammation; the herb *Cinnamomum camphora* is used as the adjuvant herb, dispelling dampness, relieving itching, and harmonizing the effects of the other herbs. Together, these three herbs form a "principal-assistant-adjuvant" formula, working synergistically to clear heat, detoxify, dispel dampness, relieve itching, and promote wound healing and tissue regeneration. Furthermore, based on traditional external treatment theory, using this herbal wash has the advantage of "effective treatment close to the disease, directly targeting the affected area." The decoction obtained from boiling fresh branches and leaves is darker in color and contains more soluble polyphenols, tannins, and flavonoids, forming a natural medicinal film on the skin surface. This not only acts as a physical barrier, preventing scratching and infection, but also prolongs the time the medication remains on the skin, promoting natural drying and scab formation of herpes lesions, embodying the traditional external treatment philosophy of "detoxification, astringency, skin protection, and tissue regeneration."

[0031] In summary, this invention, based on the TCM treatment principles of "clearing heat and detoxifying, removing dampness and relieving itching, and promoting rash eruption and tissue regeneration," combines the medicinal properties and compatibility rules of three herbs—Physalis alkekengi, Polygonum aviculare, and Paeonia lactiflora—to act on chickenpox lesions through external washing. This achieves an organic combination of TCM syndrome differentiation theory and modern pharmacological mechanisms, providing a new approach and technical foundation for the safe external treatment of chickenpox.

[0032] III. Gaps in Modern Pharmacology and Technology

[0033] Modern medical research shows that varicella-zoster virus (VZV) infection primarily attacks the skin and nervous system, inducing the host's immune cells to release various inflammatory mediators, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), leading to typical symptoms such as skin erythema, blisters, and itching. The persistence of viral replication and inflammatory response delays the drying and crusting process of blisters and increases the risk of secondary bacterial infections.

[0034] Current pharmacological research on topical treatments for chickenpox is relatively limited. Commercially available medications mostly focus on antiviral or antipruritic effects, lacking comprehensive research on skin barrier repair, inflammation control, and prevention of secondary infections. Clinically commonly used calamine lotion, antihistamine creams, and corticosteroids primarily relieve itching by inhibiting inflammatory mediators or locally paralyzing nerve endings, but they are not effective in promoting lesion healing and are unlikely to prevent bacterial infections caused by scratching.

[0035] In the field of herbal medicine research, scholars have reported on the chemical components and some pharmacological activities of medicinal materials such as *Physalis alkekengi*, *Polygonum cuspidatum*, and *Citrus aurantium*. Studies have found that:

[0036] (1) Physalis contains physalin, solanine, flavonoids and steroidal alkaloids, which have antiviral, anti-inflammatory, antioxidant and tissue repair effects. It can inhibit inflammatory signaling pathways and reduce skin damage.

[0037] (2) Polygonum multiflorum contains alkaloids, polyphenols and diterpenoids, which can significantly reduce the level of inflammatory factors, improve capillary permeability and promote skin wound repair;

[0038] (3) White rice fruit is rich in flavonoids and polyphenols, which have antibacterial, antioxidant and free radical scavenging activities. It can inhibit the growth of Staphylococcus aureus and Streptococcus pyogenes and has a potential role in preventing secondary skin infections.

[0039] Although the above research provides a foundation for the prevention and treatment of skin inflammation with traditional Chinese medicine, the following gaps and deficiencies still exist in the current technology:

[0040] (i) Research has mostly focused on single medicinal materials, lacking verification of systematic compatibility and synergistic mechanisms.

[0041] Existing studies have mostly focused on anti-inflammatory or antiviral experiments of single-drug extracts, and have not yet systematically analyzed the synergistic effects, inter-component interactions, and overall efficacy of multi-drug combinations, making it difficult to explain the overall pharmacological effects of compound topical application.

[0042] (ii) Lack of in-depth research on the local mechanism of action on the skin.

[0043] Most pharmacological studies primarily utilize in vitro cell models and have not explored the penetration and retention patterns of drugs in the stratum corneum, hair follicles, and sweat gland pathways, taking into account the characteristics of the skin barrier structure. The mechanism by which external washes improve the local microenvironment and accelerate the drying of herpes lesions by forming a drug film has not yet been clearly reported.

[0044] (iii) The active characteristics of the decoction of fresh branches and leaves have not been fully explored.

[0045] Traditional Chinese medicine preparations mostly use dried products, resulting in light-colored decoctions with limited dissolution of active substances. Experiments have shown that fresh branches and leaves are rich in polyphenols, tannins, and volatile substances; their decoction is black and possesses stronger antioxidant and astringent effects. It can form a natural protective film on the skin surface, helping to prevent infection and exudation after blisters rupture. This characteristic has not yet been systematically revealed in existing patents or literature.

[0046] (iv) Lack of standardized external washing processes and quality control methods.

[0047] Most existing traditional Chinese medicine external wash formulas are empirical preparations with vague proportions and uncontrollable processes, resulting in large differences in the concentration of the medicinal solution and the content of effective ingredients, which affects the consistency of efficacy and product stability.

[0048] Therefore, from the perspective of modern pharmacology and engineering technology, there is an urgent need to develop a novel external wash composition of traditional Chinese medicine with *Physalis alkekengi*, *Polygonum cuspidatum*, and *Citrus aurantium* as its main ingredients. By optimizing the decoction and extraction process, and utilizing the abundant natural polyphenols and tannins in fresh branches and leaves, a dark-colored medicinal film can be formed that adheres to the skin surface, achieving a multi-target comprehensive effect of anti-inflammation, antipruritic properties, infection prevention, and promoting crust formation. This innovative approach can effectively compensate for the shortcomings of existing technologies in terms of local efficacy, drug retention, and quality standardization, providing new scientific basis and technical methods for external application of traditional Chinese medicine preparations for chickenpox or herpes.

[0049] IV. Technical Problem to be Solved by the Invention

[0050] To address the problems of limited efficacy, insufficient safety, poor drug retention, and lack of topical compositions that promote scab formation in existing chickenpox treatments, this invention aims to provide a traditional Chinese medicine external wash composition, its preparation method, and its application, to achieve a comprehensive therapeutic effect targeting multiple points. Specifically, the technical problems to be solved by this invention include:

[0051] (a) Solve the problem of the single effect of topical preparations.

[0052] Existing topical medications mostly only have antipruritic or anti-inflammatory effects, making it difficult to simultaneously achieve the comprehensive effects of clearing heat and detoxifying, preventing infection, and promoting scab formation. This invention, through the rational combination of three medicinal herbs—Physalis alkekengi, Polygonum aviculare, and Citrus aurantium—forms a synergistic system, enabling the medicinal liquid to possess multiple functions during topical application: clearing heat and detoxifying, removing dampness and relieving itching, anti-inflammatory and antibacterial properties, and promoting skin repair, thereby significantly improving the redness, swelling, and itching symptoms of herpes.

[0053] (ii) Solve the problem of poor drug retention and difficulty in forming a protective film.

[0054] Traditional Chinese medicine external washes are mostly light-colored aqueous extracts with low levels of active pharmaceutical ingredients, failing to form a stable medicinal film on the skin surface. This invention innovatively uses fresh branches and leaves to decoct the herbs, resulting in a black liquid rich in polyphenols and tannins. This liquid forms a thin, uniform natural medicinal film on the skin surface, exhibiting excellent adhesion and protection. It reduces exudation and infection risks after herpes ruptures while maintaining the sustained efficacy of the medicine.

[0055] (III) Solve the problems of non-standard processes and poor stability of traditional Chinese medicine preparations.

[0056] To address the problems of inconsistent decoction times and difficulty in controlling the concentration of the medicinal solution in traditional empirical formulas, this invention establishes a standardized decoction process and dilution ratio, ensuring stable content, color, and pH value of the effective components in the resulting medicinal solution. By controlling the number of decoctions, time, and dilution ratio, consistent efficacy and product repeatability are ensured, making it suitable for both home use and industrial production.

[0057] (iv) Addressing the issues of insufficient security and applicability.

[0058] Existing topical medications containing hormones or chemical preservatives have limited use in children. This invention uses pure plant-based raw materials, extracting natural active ingredients through water decoction. It is alcohol-free, hormone-free, and chemical preservative-free, making it safe and gentle to use, especially suitable for children and people with sensitive skin.

[0059] (v) To fill the gap in the development of a special Chinese herbal wash composition for the external treatment of chickenpox.

[0060] Currently, there are no publicly available external wash preparations, either domestically or internationally, that use *Physalis alkekengi*, *Polygonum cuspidatum*, and *Fructus buergerianum* as core ingredients for the external treatment of chickenpox. This invention, by verifying the synergistic effect of the three herbs, establishes an innovative treatment system with "clearing heat and detoxifying—relieving itching and preventing infection—promoting scab formation and repair" as its core action chain. This represents a breakthrough from both traditional Chinese medicine theory and modern pharmacology perspectives, forming a novel Chinese herbal external wash composition that can be widely applied.

[0061] In summary, the present invention aims to construct a safe, effective, and standardized traditional Chinese medicine external wash preparation, overcoming the shortcomings of existing technologies such as incomplete efficacy, poor drug retention, and insufficient safety, and providing a new technical approach and implementation scheme for the external treatment of chickenpox. Summary of the Invention

[0062] I. Purpose of the Invention

[0063] This invention aims to overcome the problems of limited efficacy, insufficient safety, poor drug retention, and slow scab healing in existing topical treatments for chickenpox. It provides a safe, effective, and standardized traditional Chinese medicine (TCM) external wash composition and its preparation method. This TCM external wash composition uses three herbs: *Physalis alkekengi*, *Polygonum aviculare*, and *Citrus aurantium*. The extract obtained by decocting fresh branches and leaves forms a natural medicinal film on the skin surface. Through a synergistic chain of action—clearing heat and detoxifying, relieving itching and preventing infection, and promoting scab repair—it achieves comprehensive treatment and care for chickenpox or herpes.

[0064] II. Technical Solution

[0065] To achieve the above-mentioned technical objectives, the present invention provides a traditional Chinese medicine external washing composition, its preparation method and application.

[0066] (I) Overview of Technical Solution

[0067] The traditional Chinese medicine external washing composition of the present invention is composed of the following raw medicinal materials in parts by weight: 10-30 parts of Physalis alkekengi; 8-25 parts of Polygonum aviculare; and 5-20 parts of Evodia rutaecarpa.

[0068] The medicinal materials can be fresh branches and leaves or dried products. Fresh branches and leaves are preferred, as the decoction obtained from them is dark brown to black and contains more active polyphenols and tannins, which can form a natural medicinal film on the skin surface, improving the retention and protection of the medicine. If dried products are used, the decoction is brownish-yellow and is suitable for seasonal or large-scale production.

[0069] When using fresh branches and leaves, they should be decocted within 24 hours of collection; when using dried products, the medicinal materials should be pulverized to 20-40 mesh before decoction.

[0070] (II) Preparation method

[0071] The preparation method of the traditional Chinese medicine external wash composition of the present invention includes the following steps:

[0072] First, raw material processing

[0073] Select fresh or dried branches and leaves of Physalis alkekengi, Polygonum cuspidatum, and Citrus aurantium, and wash them to remove mud and impurities; cut fresh medicinal materials into sections of about 2-3 cm, and pulverize dried medicinal materials to 20-40 mesh.

[0074] Second, soaking and boiling extraction.

[0075] (1) Weigh the three medicinal materials according to the weight ratio, mix them evenly, and then soak them in 8 to 12 times the amount of water for 20 to 40 minutes;

[0076] (2) Boil for 30-60 minutes for the first time, then filter the decoction;

[0077] (3) Boil for 30-40 minutes for the second time, then filter the decoction;

[0078] (4) Combine the two decoctions, let stand, and then filter to remove the residue.

[0079] Third, concentration and dilution

[0080] The obtained filtrate can be concentrated or diluted according to its intended use: First, for home and clinical use, it can be directly concentrated to a relative density of 1.05 to 1.15 (80℃); Second, for industrial production, it can be diluted with sterile water at a volume ratio of 1:2 to 1:5 to obtain an external washing solution.

[0081] Fourth, sterilization and filling

[0082] The liquid medicine is sterilized by heating at 100℃ for 15 minutes, then cooled, filled, and sealed for storage. The finished liquid medicine should be black or dark brown, with a natural plant-based odor, and free of off-odors and sediment. It has a shelf life of no less than 6 months at room temperature.

[0083] (III) Instructions for Use

[0084] Heat the solution to 35-45℃ before use. Wash or apply as a wet compress to the affected area for 10-20 minutes each time, 1-2 times daily. Continuous use for 3-7 days can significantly reduce skin redness and itching, and promote the drying and crusting of chickenpox blisters. The medicated film formed after discontinuation of the medication will naturally fall off with the skin flakes within 5-7 days, restoring the skin surface to a smooth state.

[0085] To improve the storage stability of the medicinal solution, 0.1% to 0.3% of potassium sorbate or sodium benzoate is added as a preservative to the traditional Chinese medicine external washing composition.

[0086] (iv) Compatibility principle

[0087] This invention selects three medicinal materials: Physalis alkekengi, Polygonum aviculare, and Citrus aurantium, following the principle of "clearing heat and detoxifying, removing dampness and relieving itching, and promoting wound healing and tissue regeneration."

[0088] First, Physalis alkekengi is the principal ingredient, which clears heat and detoxifies, reduces swelling and relieves pain, and is mainly used to treat herpetic skin lesions caused by external heat toxins;

[0089] Secondly, the pleuroplasty is classified as an assistant herb, assisting the physalis in clearing heat and cooling blood, detoxifying and reducing inflammation, and enhancing its antibacterial and immunomodulatory effects;

[0090] Third, white rice fruit is used as an adjuvant medicine to dispel dampness, relieve itching, astringe and promote tissue regeneration, thus moderating the effects of the medicine and harmonizing the effects of other medicines.

[0091] When used together, the three medications can form a natural protective film during the rupture stage of herpes, preventing secondary infection from scratching, promoting the shedding of scabs, and restoring the complete epidermal barrier.

[0092] (V) Technical Features and Innovations

[0093] First, the decoction of fresh branches and leaves forms a black liquid: Fresh branches and leaves contain more soluble polyphenols and tannins, and the decoction is dark in color and has strong adhesion. After use, it forms a film on the skin surface, which has both protective and astringent effects.

[0094] Secondly, the medication can naturally stain the skin and prolong its effectiveness: After application, a light black film appears on the skin surface, which generally does not fade within 24 hours and naturally falls off with skin metabolism in about 5-7 days. This film can prevent external irritation, reduce the probability of secondary infection, and prolong the duration of the medication's effect.

[0095] Third, the external washing method directly reaches the affected area, which is safe and gentle: This invention uses pure Chinese herbal decoction extraction, and the preparation does not contain alcohol, hormones or chemical preservatives, thus avoiding irritation to children and sensitive skin.

[0096] Fourth, the process is simple and the quality is controllable: This invention ensures the stability of the effective ingredient content of the decoction through standardized decoction conditions and dilution ratios, making it suitable for home, clinic and industrial applications.

[0097] (vi) Optional Implementation Forms

[0098] Depending on the application scenario, the external washing composition of the present invention can also be formulated into the following dosage forms:

[0099] (1) Spray type: The medicine is sterilized and filtered and then filled into a spray bottle. It can be sprayed directly onto the affected area and is suitable for mild cases and local use.

[0100] (2) Wet compress type: The non-woven fabric is soaked in the medicine solution to make a medicated cloth, which is used for the care of large-area rashes;

[0101] (3) Soaking type: The solution is diluted and used for whole-body bathing or local soaking, suitable for children or patients with multiple rashes;

[0102] (4) Gel type: The medicine solution is made into a topical gel by adding plant colloids, which is convenient to carry and use.

[0103] (vii) Key points of quality control

[0104] To ensure the stability and safety of the medicinal solution, the present invention standardizes and controls the key parameters in the preparation process: (1) Soaking time: 20-40 minutes; (2) Decoction time: 30-60 minutes each time; (3) Total extraction rate: not less than 40%; (4) pH value: 5.0-6.0; (5) Microbial limit: ≤100cfu / mL; (6) Storage conditions: protected from light, sealed, and stored at room temperature.

[0105] Through the above technical solution, the traditional Chinese medicine external wash prepared by the present invention can form a protective film on the skin surface, continuously exert a comprehensive effect of clearing heat and detoxifying, anti-inflammatory and antipruritic, preventing infection and promoting scab formation, significantly improving the skin symptoms of patients with chickenpox or herpes, and has good safety and practical value.

[0106] III. Technical Effects

[0107] This invention utilizes a scientifically formulated blend of three medicinal herbs—Physalis alkekengi, Polygonum aviculare, and Citrus aurantium—and employs a decoction process using fresh branches and leaves. The resulting liquid is dark brown to black, rich in polyphenols, tannins, and flavonoids, exhibiting excellent anti-inflammatory, antibacterial, antipruritic, and healing-promoting effects. When applied externally to chickenpox lesions via washing or wet compresses, it forms a natural medicinal film on the skin surface, significantly improving local inflammation and accelerating the drying and crusting process of blisters. Specific technical effects are as follows:

[0108] (I) It has significant effects in clearing heat and detoxifying, and in reducing inflammation and relieving itching.

[0109] In vitro experiments have verified that the medicinal solution of this invention can significantly reduce the levels of inflammatory mediators interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), inhibit the release of inflammatory cytokines, and alleviate local skin congestion and swelling. After external washing with the medicinal solution, patients experienced a significant reduction in itching and a decrease in skin temperature, indicating that it has good heat-clearing, detoxifying, and antipruritic effects.

[0110] (ii) Formation of a drug film, prolonging the duration of drug efficacy.

[0111] The decoction obtained from the decoction of fresh branches and leaves contains a high concentration of tannins and polyphenols, which can bind to the proteins in the stratum corneum of the skin, forming a black film on the skin surface. This film has strong adhesion and possesses astringent, protective, and sustained-release effects. The decoction does not fade within 24 hours after application and naturally falls off with skin flakes in about 5-7 days. During this period, it continues to release active ingredients, resulting in a lasting therapeutic effect.

[0112] (III) Accelerating the drying, scabbing, and repair of herpes lesions

[0113] Clinical observations show that after 3-5 external washes with the solution of this invention, the exudate from the rash is significantly reduced, and the vesicles dry up approximately 24-48 hours earlier than in the control group. After 5-7 days of continuous use, most of the vesicles scab over and fall off, leaving the skin surface dry and smooth with no obvious pigmentation. This indicates that this invention can effectively shorten the course of chickenpox and accelerate skin repair.

[0114] (iv) Outstanding antibacterial and anti-infection effects

[0115] In vitro antibacterial tests showed that the drug solution of this invention has a significant inhibitory effect on common skin pathogens such as Staphylococcus aureus, Streptococcus pyogenes, and Escherichia coli, with an inhibition zone diameter of 14-18 mm, effectively reducing the risk of secondary infection caused by scratching.

[0116] (v) Safe and gentle, suitable for a wide range of people

[0117] The formulation of this invention contains natural ingredients and is free of alcohol, hormones, and chemical preservatives. Skin irritation tests showed no significant irritation to rabbit skin or mice. No allergic reactions, burning, or pain were observed after use in children or those with sensitive skin, demonstrating the high safety of this formulation and its suitability for long-term external use.

[0118] (vi) The liquid has good stability and is easy to promote and apply.

[0119] The medicinal liquid of this invention, after standardized decoction and sterilization, showed no precipitation, discoloration, or off-odor after being stored at room temperature and away from light for 6 months. The change rate of the active ingredient content was less than 5%, meeting the requirements for drug storage stability and making it suitable for widespread application in homes and medical institutions.

[0120] (vii) The process is simple, the cost is low, and it can be mass-produced.

[0121] The medicinal materials used in this invention are widely available, the decoction and extraction process is simple, no special equipment is required, the cost is low, and it is easy to achieve standardized mass production.

[0122] IV. Manifestation of Inventive Creativity

[0123] This invention, based on the traditional Chinese medicine theories of "clearing heat and detoxifying, removing dampness and relieving itching, and promoting rash eruption and tissue regeneration," and combined with modern pharmacology and process optimization, has formed a technical system with significant innovation and practicality, specifically reflected in the following aspects:

[0124] (I) Innovation in raw material selection and formulation strategies

[0125] Existing traditional Chinese medicine external wash formulas mostly focus on eczema, dermatitis, or herpes zoster, lacking specificity for chickenpox. This invention is the first to apply a specific ratio of three herbs—Physalis alkekengi, Polygonum aviculare, and Citrus aurantium—to the treatment of chickenpox, forming a rational "principal, assistant, and adjuvant" structure: Physalis alkekengi is the principal herb, primarily clearing heat and detoxifying; Polygonum aviculare is the assistant herb, assisting the principal herb in detoxification and anti-inflammation; and Citrus aurantium is the adjuvant herb, removing dampness, relieving itching, and promoting tissue regeneration. The synergistic effect of these three herbs constructs a three-in-one external wash treatment system of "clearing heat, removing dampness, and astringing," demonstrating originality in its formulation.

[0126] (II) Technological innovation in the decoction of fresh branches and leaves

[0127] Traditional external wash preparations often involve decocting dried products, resulting in a light-colored liquid with low dissolution rates of active substances. This invention innovatively proposes using fresh branches and leaves for direct decoction, yielding a dark brown to black liquid containing higher concentrations of polyphenols, tannins, and flavonoids. These active substances possess anti-inflammatory, astringent, and antibacterial properties, forming a stable medicinal film on the skin surface and enhancing drug retention. This technology overcomes the limitations of traditional dried product preparations, which suffer from low effective ingredient content and short duration of efficacy.

[0128] (III) Innovation in the external application mechanism for forming a visible drug film

[0129] After external washing with this invention, a light black medicinal film forms on the skin surface. This film is formed by the combination of polyphenols and tannins in the medicine with proteins in the stratum corneum of the skin, exhibiting natural adhesion and protection. The film does not fade within 24 hours and naturally falls off with the renewal of skin flakes in about 5-7 days. During this period, the medicinal effect is continuously released, playing a dual role in preventing infection and promoting healing. This "natural medicinal film formation mechanism" is the first of its kind proposed in the existing field of external washing with traditional Chinese medicine, demonstrating significant creativity and application value.

[0130] (iv) Innovation of multi-target comprehensive treatment model

[0131] Existing topical preparations mostly act on a single aspect, while this invention achieves a multi-target combined mechanism of "anti-inflammatory, antipruritic, antibacterial, and scab-promoting" through synergistic effects of medicinal materials and sustained-release from the outer membrane. In vitro experiments show that the solution of this invention can significantly reduce IL-6 and TNF-α levels, and has inhibitory effects on Staphylococcus aureus and Streptococcus pyogenes. The time for herpes lesions to dry and scab over is 24-48 hours earlier than that of the control group, fully demonstrating the technological advancement.

[0132] (v) Innovation in security and application scope

[0133] This invention uses entirely natural plant-based ingredients and contains no alcohol, hormones, preservatives, or other chemical additives. It is mild and safe for children and those with sensitive skin. The decoction, after being boiled and sterilized, can be stably stored at room temperature for over 6 months, providing excellent storage and transportation conditions and expanding the application range of traditional Chinese medicine external preparations.

[0134] (vi) Innovation in the feasibility of standardization and industrialization

[0135] This invention establishes clear standards for decoction temperature, time, soaking ratio, and dilution concentration, transforming traditional Chinese medicine external wash formulas from empirical preparations to repeatable and quantifiable production methods, forming a standardized process that can be widely adopted. This standardized process is not only convenient for medical institutions to prepare and use, but can also be directly applied to the industrial production of pharmaceuticals, disinfectant solutions, and daily chemical products.

[0136] Compared with the prior art, the present invention has the following technical advantages:

[0137] (i) The formula is highly targeted and has a comprehensive therapeutic effect.

[0138] Existing traditional Chinese medicine external wash formulas are mostly for diseases such as eczema, dermatitis, or herpes zoster, lacking a combination specifically for chickenpox rashes. This invention, combining the pathogenesis of chickenpox—"damp-heat accumulation and wind-heat disturbance"—selects three herbs: *Physalis alkekengi*, *Polygonum aviculare*, and *Citrus aurantium*, establishing the formulation principle of "clearing heat and detoxifying, removing dampness and relieving itching, and promoting wound healing and tissue regeneration." The three herbs work synergistically, targeting inflammation suppression, itching relief, infection prevention, and skin repair, resulting in a more comprehensive therapeutic effect than existing external medications.

[0139] (ii) The decoction process using fresh branches and leaves results in a high dissolution rate of medicinal components.

[0140] Traditional Chinese medicine external washes often involve decocting dried herbs, resulting in a light-colored liquid with low levels of active ingredients. This invention innovatively uses fresh branches and leaves for direct decoction, yielding a dark brown to black liquid rich in polyphenols, tannins, and flavonoids. This significantly enhances its anti-inflammatory, astringent, and antibacterial activities, resulting in a longer-lasting effect.

[0141] (iii) Forms a natural medicinal film, enhancing retention and protection.

[0142] After application, the medicinal solution of this invention forms a light black film on the skin surface. This film is composed of tannins and polyphenols in the solution combined with keratinocyte proteins, exhibiting strong adhesion and resistance to detachment. The film acts as a physical barrier, effectively preventing external contamination and scratching damage, while continuously releasing the medicinal effect and prolonging the duration of drug action. This is significantly superior to existing light-colored external washes that are prone to evaporation and poor retention.

[0143] (iv) Scabbing and healing are significantly accelerated, and the course of the disease is significantly shortened.

[0144] Clinical observation results showed that after external washing with the medicinal solution of this invention, the scab formation time of chickenpox blisters was 24-48 hours earlier than that of the control group. The scabs were firm and not easily detached, and the skin was smooth after healing without obvious pigmentation. This effect has not been reported in existing traditional Chinese medicine washes.

[0145] (v) Outstanding antibacterial and anti-infection effects

[0146] In vitro experiments showed that the solution of this invention has a good inhibitory effect on pathogenic bacteria such as Staphylococcus aureus and Streptococcus pyogenes, with an inhibition zone diameter of 14-18 mm. External washing with the solution can significantly reduce the incidence of secondary skin infections, reduce suppuration and scar formation, and is superior to the single symptomatic effects of ordinary calamine lotion or hormone ointments.

[0147] (vi) High safety, suitable for children and sensitive groups

[0148] The formulations of this invention are all made from natural plant extracts and contain no alcohol, hormones, or chemical preservatives. Skin irritation tests showed no adverse reactions such as erythema, papules, or burning. The solution is mild, has a light odor, and is easy to use, making it especially suitable for children, pregnant women, and people with sensitive skin.

[0149] (vii) The process is controllable and suitable for standardized and industrialized production.

[0150] This invention clearly specifies the proportions of medicinal materials, decoction time, concentration ratio, dilution ratio, and sterilization conditions, forming a repeatable process standard. The preparation process requires no complex equipment, is low-cost, and produces stable quality, enabling large-scale production and widespread application.

[0151] (viii) Good stability, convenient storage and transportation

[0152] Stability testing showed that the liquid medicine of this invention did not exhibit precipitation, stratification, or discoloration after being stored at room temperature and away from light for 6 months, indicating that its physical and chemical properties are stable and it is suitable for long-term storage and distribution. Attached Figure Description

[0153] The accompanying drawings illustrate the typical skin manifestations of the traditional Chinese medicine external wash composition described in this invention against chickenpox and herpetic lesions consistent with its pathogen. The images shown are only for illustrating the types of skin lesions and are not intended to limit the efficacy of this invention. The embodiments and scope of protection of this invention are defined in the specification and claims.

[0154] Figure 1 This is a schematic diagram of the original plant *Polygonum cuspidatum* used in the external washing composition of the present invention.

[0155] Figure 2 A schematic diagram of the original plant of *Cephalotaxus fortunei* used in the external washing composition of the present invention.

[0156] Figure 3 This is a schematic diagram of the process of decocting fresh branches and leaves according to the present invention.

[0157] Figure 4 This is a schematic diagram showing the state of chickenpox blisters on the back of the skin before using the external washing composition of the present invention.

[0158] Figure 5 This is a schematic diagram illustrating the improvement of back skin herpes after using the external washing composition of the present invention.

[0159] Figure 6 This is a schematic diagram illustrating the state of facial skin herpes before use in this invention.

[0160] Figure 7 This is a schematic diagram illustrating the improvement of facial skin herpes after using the present invention. Detailed Implementation

[0161] The following embodiments are used to further illustrate the technical solutions of the present invention, but do not constitute a limitation on the scope of protection of the present invention. Equivalent substitutions or improvements made by those skilled in the art without departing from the spirit and substance of the present invention should all fall within the scope of protection of the present invention.

[0162] Example 1: External washing solution prepared by decoction of fresh branches and leaves (recommended standard preparation process)

[0163] Raw material ratio: Take 20 parts fresh groundcherry branches and leaves, and 15 parts fresh angelica branches and leaves (see...) Figure 1 ), 10 portions of fresh white rice fruit branches and leaves (see) Figure 2 ).

[0164] Preparation method: (1) Wash the three medicinal materials and cut them into 2 cm sections; (2) Soak them in 10 times the amount of water for 30 minutes; (3) Decoction for the first time (see Figure 3(3) 60 minutes, filter the decoction; (4) 40 minutes for the second decoction, filter the decoction; (5) combine the decoctions, let them stand for 2 hours to settle, then filter; (6) concentrate to a relative density of 1.10 (80℃) to obtain the concentrated liquid; (7) dilute with sterile water at a ratio of 1:3, heat at 100℃ for 15 minutes to sterilize, then fill and seal.

[0165] Product characteristics: The liquid is dark brown, clear and transparent, with a mild odor and a pH of 5.5. It will not deteriorate when stored at room temperature away from light for 6 months.

[0166] Instructions for use: Take an appropriate amount of the solution, warm it to 40℃, and wash the affected area with the solution for 15 minutes, twice daily. After 5 consecutive days of use, the average time for the blisters to dry and scab over was 36 hours earlier than the control group. A light black film will be visible on the skin surface after use, and it will naturally fall off with the skin flakes after 6 days.

[0167] Efficacy verification: A continuous observation of 20 patients with mild to moderate chickenpox showed that after using the solution of this invention, the itching relief rate was 95%, the scab formation rate of herpes was 90%, and there were no skin irritations or allergic reactions. The effects before and after use in one chickenpox patient are shown in the figures below. Figure 4 , 5 .

[0168] Example 2: External washing solution prepared from dried product (suitable for mass production and long-term storage)

[0169] Raw material ratio: Take 15 parts of dried sour syrup, 10 parts of dried angelica sinensis, and 8 parts of dried white rice cake.

[0170] Preparation method: (1) Pulverize the dried medicinal materials to 30 mesh; (2) Mix them according to the ratio and soak them in 8 times the amount of water for 40 minutes; (3) Decoction for 60 minutes for the first time and 45 minutes for the second time, and combine the decoctions; (4) Filter to remove the residue and concentrate to a relative density of 1.08 (80℃); (5) Dilute the medicine in a ratio of 1:4, heat it at 100℃ for 15 minutes to sterilize, and then fill it.

[0171] Product characteristics: The liquid is brownish-yellow to light brown, clear and transparent, with a slightly bitter odor. It has a pH of 5.8 and shows no precipitation or discoloration after 12 months of storage at room temperature away from light.

[0172] Instructions for use: Wash or apply a wet compress to the affected area of ​​herpes for 15 minutes each time, twice daily. After 7 days of continuous use, the exudate from the rash was significantly reduced, the herpes lesions formed uniform crusts, and there was no secondary infection. See the before and after results for a herpes patient. Figure 6 , 7 .

[0173] Efficacy verification: The efficacy of the dried product preparation is slightly lower than that of the fresh branch and leaf preparation, but it has high stability and is suitable for large-scale production. Comparative experiments show that the anti-inflammatory effect of the dried product solution is about 80% of that of the fresh preparation, and it still has significant clinical value.

[0174] Example 3: Child-specific external wash (mild, low concentration version)

[0175] Raw material ratio: Take 15 parts fresh sorrel branches and leaves, 10 parts fresh angelica branches and leaves, and 8 parts fresh white rice fruit branches and leaves.

[0176] Preparation method: (1) After cleaning, add 12 times the amount of water and soak for 20 minutes; (2) Decoction twice, 30 minutes each time, and combine the decoctions; (3) After filtration, dilute at a ratio of 1:5, heat at 100℃ for 10 minutes to sterilize, and then cool and fill.

[0177] Product characteristics: The liquid is light brown with a mild odor and a pH of 5.2. It has a high dilution potential, extremely low irritation, and is suitable for children and those with sensitive skin.

[0178] Instructions for use: Take an appropriate amount of the solution and warm it to approximately 38°C. Apply as a wet compress with gauze or use as a bath wash for 10 minutes each time, once daily. Continuous use for 4 days will significantly relieve itching and accelerate the drying of blisters.

[0179] Safety and efficacy: A trial was conducted on 10 children with chickenpox, and no skin allergies or irritations were observed. Itching relief was achieved in 100% of cases, and scabs formed approximately 24 hours earlier, indicating that even low-concentration formulations have good efficacy and safety.

[0180] The spray formulation provided in this embodiment is easy to carry and use, and is suitable for home care and local treatment of children.

[0181] Efficacy verification and safety trials:

[0182] I. Experimental Objective

[0183] The purpose of this invention is to verify the anti-inflammatory, antipruritic, astringent, and anti-infective effects of the traditional Chinese medicine external wash composition in the treatment of chickenpox, and to examine its safety.

[0184] II. Experimental Materials and Methods

[0185] First, preparation of the drug solution

[0186] The decoction of fresh branches and leaves prepared by the method in Example 1 was sterilized and kept for later use.

[0187] Second, the establishment of experimental animals and models.

[0188] Sixty ICR mice, weighing (20±2) g each, with half males and half females, were selected. A skin inflammation model was established by topical application of 0.1 mL of varicella-zoster virus antigen.

[0189] 24 hours after modeling, the models were randomly divided into three groups:

[0190] Third, efficacy evaluation indicators

[0191] (1) Skin inflammation score: based on redness, swelling, exudation, and crusting, it is divided into grades 0 to 4;

[0192] (2) Determination of IL-6 and TNF-α levels: The levels of inflammatory factors in skin tissue homogenate were detected by ELISA.

[0193] (3) Record the time for herpes lesions to dry up and the time for scab formation;

[0194] (4) In vitro antibacterial test: The diameter of the inhibition zone was determined by the paper disc diffusion method;

[0195] (5) Safety observation: Record the animal's mental state, diet and skin reaction.

[0196] III. Experimental Results

[0197] First, anti-inflammatory effect

[0198] The inflammation scores for each group on day 7 are shown in the table below:

[0199] Compared with the control group, the redness and swelling and exudation in the present invention group were significantly reduced, and the degree of crusting was significantly enhanced (P<0.01).

[0200] Second, changes in inflammatory factors

[0201] The levels of IL-6 and TNF-α in skin tissue on day 7 are shown in the table below (unit: pg / mg protein):

[0202]

[0203] It is evident that the solution of this invention can significantly reduce the expression level of inflammatory mediators, and its anti-inflammatory effect is superior to that of calamine lotion.

[0204] Third, the drying and scabbing of herpes lesions.

[0205]

[0206] The results showed that the solution of the present invention could significantly promote the drying and crusting of herpes (P<0.01) and significantly shorten the course of the disease.

[0207] Fourth, in vitro antibacterial results

[0208]

[0209] The medicinal solution of this invention has a significant inhibitory effect on common skin pathogens.

[0210] Fifth, safety observation

[0211] (1) In the animal experiments, the mice in each group gained weight normally and showed no behavioral abnormalities;

[0212] (2) No erythema, edema or ulceration at the application site;

[0213] (3) Skin staining observation: After external washing with the medicine, a light black medicine film appeared on the skin, which lasted for 5 to 7 days and then fell off naturally with the skin flakes;

[0214] (4) No irritation or allergic reaction was observed, indicating that the solution is safe.

[0215] Sixth, small clinical sample validation (20 patients with mild to moderate chickenpox).

[0216]

[0217] After using the medicinal solution of this invention for 5 to 7 days, the patient's rash redness, swelling and itching were significantly reduced, the blisters dried up quickly, the scabs formed completely, the skin was smooth, and there were no allergic or irritating symptoms.

[0218] IV. Experimental Conclusions

[0219] The herbal external wash composition described in this invention has shown significant anti-inflammatory, antibacterial, antipruritic, and crust-forming effects in animal experiments and preliminary clinical trials. Compared with the control group and the positive control group, the use of the herbal wash significantly reduced skin redness and exudation, significantly decreased the levels of inflammatory factors such as IL-6 and TNF-α, and advanced the drying and crusting time of herpes by an average of about 48 hours, with a crust integrity rate of over 90%. In vitro antibacterial tests showed that the herbal wash had good inhibitory effects on Staphylococcus aureus, Streptococcus pyogenes, and Escherichia coli, with the inhibition zone diameter significantly larger than that of calamine lotion. Safety tests showed that the herbal wash was non-irritating to the skin and caused no allergic reactions. Animals showed normal weight, behavior, and appetite. In clinical trials, after 5-7 days of external washing in 20 patients with mild to moderate chickenpox, the itching relief rate reached 95%, the secondary infection rate decreased by 80%, and no adverse reactions were observed. The overall results show that the medicinal solution of the present invention can form a stable film on the skin surface, and has multiple effects such as clearing heat and detoxifying, anti-inflammatory and antipruritic, preventing infection and promoting healing. The efficacy is definite, safe and reliable, and the therapeutic effect is significantly better than that of existing topical preparations. It has broad clinical application value and industrialization prospects.

Claims

1. A traditional Chinese medicine external wash composition, characterized in that, The raw medicinal materials include the following parts by weight: 10-30 parts of Physalis alkekengi, 8-25 parts of Polygonum aviculare, and 5-20 parts of Citrus aurantium.

2. The traditional Chinese medicine external wash composition according to claim 1, characterized in that, The raw materials for the sour physalis, guaiac, and white rice fruit are fresh branches and leaves or dried products.

3. The traditional Chinese medicine external wash composition according to claim 1, characterized in that, When using fresh branches and leaves, they should be added to the decoction within 24 hours of collection.

4. The traditional Chinese medicine external wash composition according to claim 1, characterized in that, When using dried products, the medicinal materials should be pulverized to 20-40 mesh before decoction.

5. The traditional Chinese medicine external wash composition according to any one of claims 1 to 4, characterized in that, The raw medicinal materials are mixed in proportion and then 8 to 12 times the amount of water is added. The mixture is soaked for 20 to 40 minutes, decocted twice for 30 to 60 minutes each time, and the decoctions are combined, allowed to stand, filtered, and then concentrated or diluted at a ratio of 1:2 to 1:5 to obtain the external washing solution.

6. A method for preparing a traditional Chinese medicine external wash composition according to any one of claims 1 to 5, characterized in that, Includes the following steps: (1) Collect fresh or dried branches and leaves of Physalis alkekengi, Gynostemma pentaphyllum and Scutellaria baicalensis, wash and remove impurities, and cut into sections for later use; (2) Mix according to the weight ratio, add 8 to 12 times the amount of water and soak for 20 to 40 minutes; (3) Heat and boil 2 to 3 times, each time for 30 to 60 minutes, and combine the decoctions; (4) Filter to remove residue, concentrate to a relative density of 1.05-1.15 (80℃), and dilute to form an external washing solution; (5) Sterilize by heating at 100°C for 15 minutes, cool and then fill and seal for storage.

7. The application of a traditional Chinese medicine external wash composition prepared according to the preparation method of claim 6, characterized in that, To improve the storage stability of the medicinal solution, 0.1% to 0.3% of potassium sorbate or sodium benzoate is added as a preservative to the traditional Chinese medicine external washing composition.

8. The application of a traditional Chinese medicine external wash composition prepared according to the preparation method of claim 6, characterized in that, In addition to being a wash solution, the medicinal liquid can also be prepared as a topical dosage form such as a wet compress, spray, gel, or soaking solution.

9. The application of the traditional Chinese medicine external wash composition according to claim 8, characterized in that, Heat the medicinal solution to 35-45℃ and apply it directly to the chickenpox rashes and scabs for external washing or wet compresses for 10-20 minutes each time, 1-2 times a day, for 3-7 consecutive days. This can significantly shorten the drying time of chickenpox blisters and promote skin recovery.

10. The application of the traditional Chinese medicine external wash composition according to claim 9, characterized in that, The herbal external wash composition is used to relieve skin itching, redness, swelling and oozing caused by chickenpox or herpes, promote the drying and crusting of herpes, and reduce scratching and secondary infection.

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