Nutritional composition for short-time internal inflammation balance after medium-high-intensity resistance training and application of nutritional composition

Abstract

The invention discloses a nutritional composition for short-time internal inflammation balance after medium-high-strength resistance training and application of the nutritional composition, and belongs to the technical field of food processing. The composition comprises an inflammation control component composed of a plant inflammation control component and a milk source inflammation control component, the inflammation control component is composed of a plant source component and a milk source component and specifically comprises omega-3 unsaturated fatty acid, curcumin, iron unsaturated lactoferrin and a milk fat globule membrane according to a specific weight ratio, the weight ratio of EPA to DHA in the omega-3 unsaturated fatty acid is not lower than 1.5: 1, and the weight ratio of the curcumin to the iron unsaturated lactoferrin to the milk fat globule membrane is not lower than 1.5: 1. The iron saturation of the iron unsaturated lactoferrin is less than or equal to 30%, and the phospholipid accounts for 4-10% of the milk fat ball membrane. Experimental results show that the composition can effectively regulate and control the level of inflammatory factors within 6 hours after training, and accurate regulation and control of inflammatory response within an inflammatory regulation window period within 6 hours after training are achieved. The invention also relates to application of the composition in preparation of functional food and dairy products.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of food processing, and relates to a nutritional composition, in particular, a nutritional composition for short-term inflammation balance after medium-high intensity resistance training and application thereof. BACKGROUND

[0002] With age, human muscle mass decreases progressively after the age of 30. When the total amount of muscle attenuation exceeds a certain threshold, muscle attenuation syndrome develops, affecting physiological function. Among the interventions to combat muscle loss, medium-high intensity resistance training, represented by 65%-85% 1RM, can effectively activate muscle hypertrophy mechanisms and promote muscle growth.

[0003] However, the physiological response after resistance training has a clear time sequence feature. Within 2-6 hours after training, the body enters a special inflammation regulation stage. This short-term inflammation has a dual nature: moderate inflammation is a necessary signal to start the repair process, which can remove damaged tissues and activate repair mechanisms; but excessive inflammation will hinder the recovery process, inhibit muscle synthesis signaling pathways, and prolong functional recovery time.

[0004] Existing nutritional supplements after resistance training are still mainly based on the idea of supplementing protein and carbohydrates, providing amino acids and energy substrates to support muscle repair. The special value of inflammation balance regulation within 6 hours after medium-high intensity resistance training is often not recognized, and there is a lack of special design for this specific time window. This leads to a mismatch between the nutritional supplement strategy and the timing of physiological changes after training, affecting the final recovery effect.

[0005] Some anti-inflammatory ingredients currently used also have obvious limitations. For example, milk fat globule membrane has a relatively single mechanism of action, mainly by inhibiting core inflammation pathways. This mode of action can reduce inflammation factor levels, but at the same time, it inhibits the inflammation signals necessary for repair. Other single anti-inflammatory ingredients also face similar problems, making it difficult to achieve precise regulation of inflammation balance suitable for body recovery. SUMMARY

[0006] The purpose of the present application is to provide a nutritional composition for short-term inflammation balance after medium-high intensity resistance training and application thereof. The key synergistic effect of four specific ingredients, EPA:DHA=1.5-3:1 omega-3 unsaturated fatty acids, iron unsaturated lactoferrin, milk fat globule membrane with specific phospholipid content, and curcumin, achieves precise regulation of inflammation response during the 6-hour inflammation regulation window after training.

[0007] The present application is dedicated to solving the problem of ignoring the regulation needs of inflammation balance at a specific stage after medium-high intensity resistance training, which is common in existing muscle-building anti-inflammatory nutritional products.

[0008] To achieve the above object, the technical scheme adopted by the present application is: A nutritional composition for short-term inflammation balance after medium-high intensity resistance training, comprising an inflammation control component composed of a plant inflammation control component and a milk-derived inflammation control component; The plant inflammation control component is composed of omega-3 unsaturated fatty acids and curcumin; The milk-derived inflammation control component is composed of unsaturated ferritin and milk fat globule membrane in a weight ratio of 1:1-2; The weight ratio of omega-3 unsaturated fatty acids, curcumin and milk-derived inflammation control component is 2-5:1:2; Among them, the omega-3 unsaturated fatty acids are unsaturated fatty acids with a weight ratio of EPA:DHA=1.5-3:1; The iron saturation of the unsaturated ferritin is ≤30%; The weight ratio of phospholipids in the milk fat globule membrane is 4%-10%.

[0009] Further, the unsaturated ferritin is a natural glycosylated form of complete molecule derived from cow milk.

[0010] As a limitation, 0.5-2 parts by weight of the inflammation control component, 25-40 parts by weight of protein synthesis component, 30-60 parts by weight of carbohydrate, and 0.1-0.5 parts by weight of immune regulation component are included.

[0011] As another limitation, the protein synthesis component is leucine and beta-hydroxy-beta-methylbutyric acid.

[0012] Further, the weight ratio of leucine and beta-hydroxy-beta-methylbutyric acid is preferably 2:1.

[0013] Further, the carbohydrate includes at least one of glucose, fructose, maltose, sucrose and oligosaccharide. Further, the immune regulation component includes glutamine and immunoglobulin. Further, the weight ratio of glutamine and immunoglobulin is preferably 2:1.

[0014] The present application also provides a use of the above-mentioned nutritional composition in the preparation of a functional food for regulating inflammation balance. The present application also provides a use of the above-mentioned nutritional composition in the preparation of a functional dairy product for regulating inflammation balance. Further, the above-mentioned nutritional composition is added to the raw materials for preparing adult formula milk powder. The application also provides a method for regulating inflammation balance in a short time after high-intensity resistance training, which is to use the above-mentioned nutritional composition for inflammation balance in a short time after high-intensity resistance training as a nutritional supplement after high-intensity resistance training to achieve regulation of inflammation balance in a 6-hour inflammation regulation window period after high-intensity resistance training.

[0015] Compared with the prior art, the application has the following technical progress: ①The nutritional composition for inflammation balance in a short time after high-intensity resistance training provided by the application takes a synergistic system of plant inflammation control components and milk-derived inflammation control components as key components, which not only maintains necessary inflammation signals to start the repair mechanism, but also inhibits excessive inflammation, thereby regulating inflammation balance to ensure the recovery process of the body, and thus solving the problem that a single anti-inflammatory component cannot adapt to the demand for inflammation balance in a short time window period after training.

[0016] ②The nutritional composition for inflammation balance in a short time after high-intensity resistance training provided by the application regulates inflammation balance through the synergistic effect of specific components and ratios. The inflammation control components are composed of omega-3 unsaturated fatty acids, curcumin and milk-derived inflammation control components in a weight ratio of 2-5:1:2; the milk-derived inflammation control components are composed of iron unsaturated lactoferrin and milk fat globule membrane in a weight ratio of 1:1-2; the ratio of EPA to DHA in the omega-3 unsaturated fatty acids is not less than 1.5:1; the iron saturation of the iron unsaturated lactoferrin is not higher than 30%; and the proportion of phospholipids in the milk fat globule membrane is not less than 4%. Under this specific composition, the iron unsaturated lactoferrin preferentially chelates free iron released after exercise to suppress excessive initiation of inflammation signals from the source; curcumin and milk fat globule membrane produce synergistic and complementary effects in inhibiting core inflammation pathways such as NF-κB, effectively avoiding complete inhibition of inflammation signals required for repair; milk fat globule membrane further promotes the conversion of macrophages to M2 type for anti-inflammatory and repair promotion; and the omega-3 unsaturated fatty acids with a high proportion of EPA actively promote inflammation subsidence through their metabolites. The components are connected to each other in terms of action sequence and target, and together achieve a balanced state of retaining beneficial repair signals while inhibiting destructive inflammation.

[0017] ③The present application realizes the synergistic effect of the nutritional components by compounding the anti-inflammatory component, the protein synthesis component, the carbohydrate and the immune-regulating component in a weight ratio of 0.5-2:25-40:30-60:0.1-0.5, and in this ratio, the insulin secretion promoted by the carbohydrate and the protein synthesis component together accelerate the transport of amino acids to muscle tissue and protein synthesis, providing a material basis for body repair; this anabolic environment and the anti-inflammatory microenvironment created by the anti-inflammatory component synergize with each other to optimize the muscle repair efficiency; at the same time, the immune-regulating component can more effectively support the stability of the overall immune system in this nutritional environment, consolidating the inflammation balance state, and this compounding scheme realizes all-round recovery support from inflammation control, protein synthesis to energy supplementation. DETAILED DESCRIPTION

[0018] The present application will be further described in detail by specific examples. It should be understood that the described examples are only for the purpose of explaining the present application and do not limit the present application.

[0019] The experimental methods used in the following examples are conventional methods in the art unless otherwise specified. The materials, reagents, etc. used in the following examples can be obtained from commercial channels unless otherwise specified.

[0020] Example 1 This example is a nutritional composition for short-term inflammation balance after moderate to high intensity resistance training, denoted as composition Z1, which is composed of 1.2 kg of anti-inflammatory components, 33 kg of protein synthesis components, 40 kg of carbohydrates and 0.2 kg of immune-regulating components. The anti-inflammatory components in this example are a complex system composed of two types of active substances, plant anti-inflammatory components and dairy anti-inflammatory components; the plant anti-inflammatory components are a combination of omega-3 unsaturated fatty acids and curcumin, and the dairy anti-inflammatory components are composed of unsaturated lactoferrin and milk fat globule membrane in a weight ratio of 1:1. In this complex anti-inflammatory system, the weight ratio of omega-3 unsaturated fatty acids, curcumin and dairy anti-inflammatory components is 3:1:2. That is, the anti-inflammatory components are composed of 0.3 kg of omega-3 unsaturated fatty acids, 0.2 kg of curcumin, 0.2 kg of unsaturated lactoferrin and 0.2 kg of milk fat globule membrane.

[0021] Among them, the omega-3 unsaturated fatty acids require an eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) weight ratio of 1.5:1 to competitively reduce the release of the pro-inflammatory factor arachidonic acid (ARA), effectively clear inflammatory factors and promote tissue repair. The two omega-3 unsaturated fatty acids play a synergistic role in the long-term inflammation reduction process. The iron-unsaturated lactoferrin has an iron saturation of ≤30% and is a complete molecule derived from the natural glycosylated form of cow's milk. At the same time, the phospholipid weight percentage of the milk fat globule membrane is 4%~10%.

[0022] In this embodiment, the protein synthesis components consist of leucine and β-hydroxy-β-methylbutyric acid in a weight ratio of 2:1.

[0023] In this embodiment, the carbohydrate consists of equal amounts of glucose, fructose, and maltose.

[0024] In this embodiment, the immunomodulatory component consists of glutamine and immunoglobulin in a weight ratio of 2:1. The immunoglobulin is obtained by directly adding immunoglobulin raw materials or by adding milk with an immunoglobulin content that meets the requirements.

[0025] The composition Z1 of this embodiment, through a specific combination of the above-mentioned components and proportions, rapidly regulates the acute inflammatory response induced by exercise during the post-training window, thereby effectively promoting the body's recovery process by regulating the inflammatory balance.

[0026] Effect Experiment Example 1 The effects of the composition Z1 prepared in Example 1 of this invention on the inflammatory balance after medium-to-high intensity resistance training were verified by detecting changes in inflammation and muscle recovery indicators 6 hours after medium-to-high intensity resistance training.

[0027] The specific experimental method is as follows: (1) Experimental design: A randomized, double-blind, crossover experimental design was adopted, and 40 healthy male subjects were recruited. All subjects completed 10 sets of moderate-to-high intensity resistance training at 80% of 1RM. The experiment was set up with three groups for comparison: No intervention group: no nutritional intervention was given after training; Composition Z1 group: Composition Z1 of the present invention was supplemented after training; Ordinary anti-inflammatory group: Ibuprofen 400mg and vitamin C 500mg were taken after training.

[0028] (2) Detection Indicators and Methods: Changes in inflammation and recovery indicators were detected within 6 hours after training. Serum ELISA levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were measured; nuclear factor-κB (NF-κB) activity was determined using electrophoretic mobility shift analysis (EMSA); and the degree of delayed onset muscle soreness (DOMS) was assessed using the visual analog scale. In the DOMS assessment of soreness, no pain was scored as 0 points and severe pain as 10 points, with scores based on the subject's experience.

[0029] Among the various indicators tested: TNF-α is an inflammation-related cytokine secreted by macrophages. High-intensity resistance training can induce muscle micro-damage, leading to a significant increase in TNF-α levels after exercise. TNF-α works synergistically with inflammatory factors such as IL-6 to participate in tissue repair. Short-term increases in TNF-α activate the NF-κB pathway, stimulating the proliferation of muscle satellite cells and accelerating muscle regeneration. IL-6 is a pleiotropic cytokine produced by immune cells, endothelial cells, etc., and participates in physiological processes such as immune regulation, inflammatory responses, and metabolic regulation. Its normal serum concentration is usually low, but it is significantly elevated in infections, trauma, or chronic diseases. High-intensity resistance training can induce a rapid increase in IL-6, with peak values ​​occurring 2-4 hours after exercise, reaching levels several times higher than baseline. NF-κB is a transcription factor that regulates inflammation, immunity, and cell survival. High-intensity resistance training may temporarily activate NF-κB through mechanical stress or metabolic stress (such as the accumulation of reactive oxygen species), promoting the release of inflammatory factors (such as TNF-α and IL-6) and participating in muscle repair and adaptive remodeling.

[0030] (3) The results are shown in Table 1.

[0031] Table 1. Comparison of inflammation and recovery indicators 6 hours after resistance training Note: In the table, superscript 1 indicates p < 0.01 compared to the non-intervention group, and 2 indicates p < 0.05 compared to the composition Z1 group of Example 1 of this invention.

[0032] The results showed that, compared with the non-intervention group, the Z1 composition group exhibited significantly reduced TNF-α and IL-6 levels (>50%), while preserving and increasing NF-κB activity by 15%, ensuring normal transmission of repair signals. The Z1 composition group of Example 1 of this invention showed a 51% reduction in DOMS pain scores, demonstrating effective relief of discomfort without interfering with repair. The conventional anti-inflammatory group excessively inhibited NF-κB activity, leaving only 15%, leading to interruption of muscle repair signals. The non-intervention group resulted in persistent inflammatory damage.

[0033] Experimental results show that the nutritional composition of this invention can effectively reduce the level of inflammatory factors after exercise, relieve muscle soreness, and preserve the activity of the necessary NF-κB signaling pathway. This regulatory mode controls excessive inflammatory response while ensuring the transmission of physiological signals required for muscle repair, achieving the goal of regulating inflammatory balance. In contrast, while common anti-inflammatory drugs can inhibit inflammation, they may hinder the normal muscle repair process.

[0034] Comparative Example 1 This comparative example is a nutritional composition D1, whose components and amounts are basically the same as those in Example 1. The only difference is that the Ω-3 unsaturated fatty acids are composed of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in a weight ratio of 1:2, and the iron saturation of lactoferrin is >30%.

[0035] Comparative Example 2 This comparative example is a nutritional composition D2, whose components and dosages are basically the same as those in Example 1, except that the proportion of phospholipids in the milk fat globule membrane is 2% and the content of sphingomyelin is 35g / 100g phospholipids.

[0036] Comparative Example 3 This comparative example is a nutritional composition D3. The components and amounts of this composition are basically the same as those in Example 1. The only difference is that Ω-3 unsaturated fatty acids are not added, but curcumin is added instead. The specific anti-inflammatory components are: 0.5 kg of curcumin, 0.2 kg of iron-unsaturated lactoferrin and 0.2 kg of milk fat globule membrane.

[0037] Effect Experiment Example 2 This experimental example examines the changes in inflammation and muscle recovery indicators 6 hours after moderate-to-high intensity resistance training, comparing the regulatory effects of composition Z1 prepared in Example 1 of this invention and nutritional compositions D1-D3 prepared in Comparative Examples 1-3 on the inflammatory balance after moderate-to-high intensity resistance training.

[0038] The experimental method and effect were the same as in Experiment 1, and the results are shown in Table 2.

[0039] Table 2 Comparison of inflammation and recovery indicators 6 hours after resistance training Note: In the table, superscript 1 indicates p < 0.01 compared to the non-intervention group, and 2 indicates p < 0.05 compared to the composition Z1 group of Example 1 of this invention.

[0040] The results showed that although there was no significant difference in DOMS scores, TNF-α and IL-6 in nutritional composition groups D1 and D2 were significantly higher than those in composition group Z1 of Example 1 of the present invention, indicating poor anti-inflammatory effects. In terms of NF-κB activity, nutritional composition groups D1 and D3 were significantly lower than those in composition group Z1 of Example 1 of the present invention, indicating that they excessively inhibited the NF-κB pathway, which in turn affected the transmission of muscle repair signals.

[0041] The above results demonstrate that the present invention, with its rational formulation of specific nutrient components, can more effectively support the stability of the overall immune system, consolidate the inflammatory balance, and avoid excessive inhibition of the NF-κB pathway. It can promote bodily repair by regulating the inflammatory balance shortly after moderate-to-high intensity resistance training. Through the precise formulation of key components such as omega-3 fatty acids (in a specific ratio), milk fat globule membrane (with a specific composition), and curcumin, comparative experiments have shown that any deviation from a single component (such as changing the fatty acid ratio, replacing membrane components, or removing core components) will disrupt the precise balance between anti-inflammatory and repair-promoting effects, leading to insufficient anti-inflammatory effects or excessive inhibition of the NF-κB signaling pathway necessary for muscle repair. This indicates that the overall formulation of the present invention has an irreplaceable anti-inflammatory effect in synergistically regulating post-exercise recovery.

[0042] Example 2 This embodiment is a nutritional composition for short-term inflammatory balance after medium-to-high intensity resistance training. The composition consists of a mixture of 1 kg of anti-inflammatory components, 25 kg of protein synthesis components, 40 kg of carbohydrates, and 0.2 kg of immunomodulatory components.

[0043] In this embodiment, the anti-inflammatory component is a complex system composed of two types of active substances: plant-based anti-inflammatory components and milk-derived anti-inflammatory components. The plant-based anti-inflammatory component is a combination of omega-3 unsaturated fatty acids and curcumin, while the milk-derived anti-inflammatory component consists of iron-unsaturated lactoferrin and milk fat globule membrane in a 1:1 weight ratio. In this complex anti-inflammatory system, the weight ratio of omega-3 unsaturated fatty acids, curcumin, and milk-derived anti-inflammatory components is 3:1:2.

[0044] Among them, the omega-3 unsaturated fatty acids require an eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) weight ratio of 3:1 to competitively reduce the release of the pro-inflammatory factor arachidonic acid (ARA), effectively clear inflammatory factors and promote tissue repair. The two omega-3 unsaturated fatty acids play a synergistic role in the long-term inflammation reduction process. The iron-unsaturated lactoferrin has an iron saturation of ≤30% and is a complete molecule derived from the natural glycosylated form of cow's milk. At the same time, the weight percentage of phospholipids in the milk fat globule membrane is ≥4%.

[0045] In this embodiment, the protein synthesis components consist of leucine and β-hydroxy-β-methylbutyric acid in a weight ratio of 2:1.

[0046] In this embodiment, the carbohydrate is composed of a mixture of glucose, sucrose and oligosaccharides in a weight ratio of 2:1:1.

[0047] In this embodiment, the immunomodulatory component consists of glutamine and immunoglobulin in a weight ratio of 2:1.

[0048] The composition of this embodiment, through a specific combination of the above-mentioned components and proportions, rapidly regulates the acute inflammatory response induced by exercise during the post-training window, thereby effectively promoting the body's recovery process by regulating inflammatory balance.

[0049] Example 3 This embodiment is a nutritional composition for short-term inflammatory balance after medium-to-high intensity resistance training. The composition consists of a mixture of 2 kg of anti-inflammatory components, 40 kg of protein synthesis components, 30 kg of carbohydrates, and 0.3 kg of immunomodulatory components.

[0050] In this embodiment, the anti-inflammatory component is a complex system composed of two types of active substances: plant-based anti-inflammatory components and milk-derived anti-inflammatory components. The plant-based anti-inflammatory component is a combination of omega-3 unsaturated fatty acids and curcumin, while the milk-derived anti-inflammatory component consists of iron-unsaturated lactoferrin and milk fat globule membrane in a weight ratio of 1:1.5. In this complex anti-inflammatory system, the weight ratio of omega-3 unsaturated fatty acids, curcumin, and milk-derived anti-inflammatory components is 2:1:2.

[0051] Among them, the omega-3 unsaturated fatty acids require an eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) weight ratio of 2.5:1 to competitively reduce the release of the pro-inflammatory factor arachidonic acid (ARA), effectively clear inflammatory factors and promote tissue repair. The two omega-3 unsaturated fatty acids play a synergistic role in the long-term inflammation reduction process. The iron-unsaturated lactoferrin has an iron saturation of ≤30% and is a complete molecule derived from the natural glycosylated form of cow's milk. At the same time, the weight percentage of phospholipids in the milk fat globule membrane is ≥4%.

[0052] In this embodiment, the protein synthesis components consist of leucine and β-hydroxy-β-methylbutyric acid in a weight ratio of 2:1.

[0053] In this embodiment, the carbohydrate is composed of equal amounts of glucose, fructose, maltose, sucrose, and oligosaccharides.

[0054] In this embodiment, the immunomodulatory component consists of glutamine and immunoglobulin in a weight ratio of 2:1.

[0055] The composition of this embodiment, through a specific combination of the above-mentioned components and proportions, rapidly regulates the acute inflammatory response induced by exercise during the post-training window, thereby effectively promoting the body's recovery process by regulating inflammatory balance.

[0056] Example 4 This embodiment is a nutritional composition for short-term inflammatory balance after medium-to-high intensity resistance training. The composition consists of a mixture of 0.5 kg of anti-inflammatory components, 25 kg of protein synthesis components, 50 kg of carbohydrates, and 0.1 kg of immunomodulatory components.

[0057] In this embodiment, the anti-inflammatory component is a complex system composed of two types of active substances: plant-based anti-inflammatory components and milk-derived anti-inflammatory components. The plant-based anti-inflammatory component is a combination of omega-3 unsaturated fatty acids and curcumin, while the milk-derived anti-inflammatory component consists of iron-unsaturated lactoferrin and milk fat globule membrane in a weight ratio of 1:1.8. In this complex anti-inflammatory system, the weight ratio of omega-3 unsaturated fatty acids, curcumin, and milk-derived anti-inflammatory components is 5:1:2.

[0058] Among them, the omega-3 unsaturated fatty acids require an eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) weight ratio of 2:1 to competitively reduce the release of the pro-inflammatory factor arachidonic acid (ARA), effectively clear inflammatory factors and promote tissue repair. The two omega-3 unsaturated fatty acids play a synergistic role in the long-term inflammation reduction process. The iron-unsaturated lactoferrin has an iron saturation of ≤30% and is a complete molecule derived from the natural glycosylated form of cow's milk. At the same time, the weight percentage of phospholipids in the milk fat globule membrane is ≥4%.

[0059] In this embodiment, the protein synthesis components consist of leucine and β-hydroxy-β-methylbutyric acid in a weight ratio of 2:1.

[0060] In this embodiment, the carbohydrates consist of glucose, fructose, maltose, sucrose, and oligosaccharides in a weight ratio of 3:1:1:1:1.

[0061] In this embodiment, the immunomodulatory component consists of glutamine and immunoglobulin in a weight ratio of 2:1.

[0062] The composition of this embodiment, through a specific combination of the above-mentioned components and proportions, rapidly regulates the acute inflammatory response induced by exercise during the post-training window, thereby effectively promoting the body's recovery process by regulating inflammatory balance.

[0063] Example 5 This embodiment is a nutritional composition for short-term inflammatory balance after medium-to-high intensity resistance training. The composition consists of a mixture of 1.5 kg of anti-inflammatory components, 30 kg of protein synthesis components, 60 kg of carbohydrates, and 0.5 kg of immunomodulatory components.

[0064] In this embodiment, the anti-inflammatory component is a complex system composed of two types of active substances: plant-based anti-inflammatory components and milk-derived anti-inflammatory components. The plant-based anti-inflammatory component is a combination of omega-3 unsaturated fatty acids and curcumin, while the milk-derived anti-inflammatory component consists of iron-unsaturated lactoferrin and milk fat globule membrane in a 1:1 weight ratio. In this complex anti-inflammatory system, the weight ratio of omega-3 unsaturated fatty acids, curcumin, and milk-derived anti-inflammatory components is 4:1:2.

[0065] Among them, the omega-3 unsaturated fatty acids require an eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) weight ratio of 3:1 to competitively reduce the release of the pro-inflammatory factor arachidonic acid (ARA), effectively clear inflammatory factors and promote tissue repair. The two omega-3 unsaturated fatty acids play a synergistic role in the long-term inflammation reduction process. The iron-unsaturated lactoferrin has an iron saturation of ≤30% and is a complete molecule derived from the natural glycosylated form of cow's milk. At the same time, the weight percentage of phospholipids in the milk fat globule membrane is ≥4%.

[0066] In this embodiment, the protein synthesis components consist of leucine and β-hydroxy-β-methylbutyric acid in a weight ratio of 2:1.

[0067] In this embodiment, the carbohydrate is composed of equal amounts of fructose and maltose.

[0068] In this embodiment, the immunomodulatory component consists of glutamine and immunoglobulin in a weight ratio of 2:1.

[0069] The composition of this embodiment, through a specific combination of the above-mentioned components and proportions, rapidly regulates the acute inflammatory response induced by exercise during the post-training window, thereby effectively promoting the body's recovery process by regulating inflammatory balance.

[0070] In other embodiments, the carbohydrates are composed of at least one of glucose, fructose, maltose, sucrose, and oligosaccharides, all of which can successfully prepare a nutritional composition for short-term inflammatory balance after medium- to high-intensity resistance training.

[0071] In other embodiments, a functional food for regulating inflammatory balance is prepared by adding a flavoring agent to any of the nutritional compositions in Examples 1-5 that regulate inflammatory balance in a short period of time after high-intensity resistance training. In practice, the nutritional composition of the present invention can be transformed into products of different forms through conventional food processing methods. For example, by mixing the composition with a flavoring agent, it can be processed into solid beverage powder, protein bars, or ready-to-drink liquid beverages.

[0072] The nutritional composition of this invention, which regulates inflammatory balance in the short term after moderate-to-high intensity resistance training, is also applicable to dairy product systems. One embodiment involves adding the composition to raw materials used in the production of adult formula milk powder, and then producing the finished product through mixing and spray drying. Another embodiment involves processing the composition, particularly its milk-derived components, with milk-based raw materials to prepare fermented dairy products or flavored milk beverages. In terms of application, this invention also provides a pathway for regulating post-exercise inflammatory responses through nutritional supplementation. This method involves ingesting a unit dose of the nutritional composition after moderate-to-high intensity resistance training. By ingesting this specific composition, the inflammatory response process in the body after training is intervened.

Claims

1. A nutritional composition for use in the balance of inflammation in the short term after moderate to high intensity resistance training, characterized in that, The anti-inflammatory ingredients comprise plant anti-inflammatory ingredients and milk-derived anti-inflammatory ingredients; The plant anti-inflammatory ingredients comprise omega-3 unsaturated fatty acids and curcumin; The milk-derived anti-inflammatory ingredients comprise unsaturated ferro-lactoferrin and milk fat globule membrane at a weight ratio of 1:1-2; The weight ratio of the omega-3 unsaturated fatty acids, curcumin and milk-derived anti-inflammatory ingredients is 2-5:1:2; The omega-3 unsaturated fatty acids are unsaturated fatty acids with a ratio of EPA:DHA of 1.5-3:

1. The iron saturation of the unsaturated ferro-lactoferrin is ≤30%. The weight ratio of phospholipids in the milk fat globule membrane is 4%-10%.

2. Nutritional composition for the post-acute phase inflammatory balance after moderate-high intensity resistance training according to claim 1, characterized in that, The anti-inflammatory ingredients, 0.5-2 parts by weight; protein synthesis ingredients, 25-40 parts by weight; carbohydrates, 30-60 parts by weight; and immune regulation ingredients, 0.1-0.5 parts by weight.

3. Nutritional composition for the post-exercise inflammatory balance in the short term after moderate-high intensity resistance training according to claim 2, characterized by the fact that, The protein synthesis ingredients are leucine and beta-hydroxy-beta-methylbutyric acid.

4. Nutritional composition for the post-acute phase inflammatory balance after moderate-high intensity resistance training according to claim 2, characterized in that, The carbohydrates comprise at least one of glucose, fructose, maltose, sucrose and oligosaccharides.

5. Nutritional composition for the balance of inflammation in the short term after moderate to high intensity resistance training according to any one of claims 2 to 4, characterized in that, The immune regulation ingredients comprise glutamine and immunoglobulin.

6. Use of the nutritional composition for short-term inflammation balance after medium-high intensity resistance training according to any one of claims 1-5 in the preparation of a functional food for regulating inflammation balance.

7. Use of the nutritional composition for short-term inflammation balance after medium-high intensity resistance training according to any one of claims 1-5 in the preparation of a functional dairy product for regulating inflammation balance.

8. The adult formula of claim 7, wherein, The nutritional composition for short-term inflammation balance after medium-high intensity resistance training according to any one of claims 1-5 is added to raw materials for preparing adult formula milk powder.

9. A method of modulating the inflammatory balance in the short term after moderate to high intensity resistance training, characterized in that, The nutritional composition for short-term inflammation balance after medium-high intensity resistance training according to any one of claims 1-5 is used as a nutritional supplement after medium-high intensity resistance training.

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