Cervical cancer slide scanning device and working method thereof

Abstract

The application discloses a cervical cancer slide scanning device and a working method thereof. The cervical cancer slide scanning device is used for scanning and screening of a cervical cancer sample slide, and comprises an electron microscope and a stage. The device further comprises a base, an electron microscope and an electric stage are arranged at the middle position of the top platform plate of the base; a front warehouse mechanism is arranged at the right side of the stage, the front warehouse mechanism is vertically provided with a front warehouse chamber, a plurality of slide trays to be scanned and screened are stacked in the front warehouse chamber, and a push-out assembly is arranged at the bottom of the front warehouse chamber; a rear warehouse mechanism is arranged at the left side of the stage, the rear warehouse mechanism is vertically provided with a rear warehouse chamber, a plurality of slide trays to be scanned and screened are stacked in the rear warehouse chamber, and a rear warehouse bottom mechanism for pulling a single slide tray from the stage is arranged at the bottom of the rear warehouse chamber. The device realizes continuous automatic feeding and discharging, greatly improves the scanning efficiency of the microscope, fully utilizes the stage, and has low production and manufacturing cost.

Description

Technical Field

[0001] This invention relates to the field of electron microscope scanning equipment technology, and in particular to a cervical cancer slide scanning device and its working method. Background Technology

[0002] Cervical cancer is one of the most common cancers worldwide, and early screening plays a crucial role in its effective prevention. Timely detection and intervention to prevent precancerous cervical lesions are essential for treatment. Screening methods, such as cervical cytology screening, are recommended for population screening due to their simplicity and affordability. However, a severe shortage of cytopathologists in this field leads to low efficiency in cervical cytology screening and a high risk of human error, with a false negative rate often exceeding 10% in routine diagnoses.

[0003] Furthermore, traditional microscopic image scanning requires manual operation. Sample slides are placed on a stage, and the microscope is moved to scan and observe each sample individually. While this method can acquire images, the scanning speed is relatively slow, especially for large samples or applications requiring high-resolution imaging, where the scanning time can be very long. Prolonged scanning not only reduces work efficiency but also causes operator fatigue. Therefore, traditional cervical cancer cell microscopic image scanning faces challenges when processing large amounts of data.

[0004] Patent CN112965233A discloses a microscope scanner capable of automatically loading slides in batches. It includes a slide box loading module, a slide box moving module, a slide scanning module, a visual recognition module, and a slide box recycling module. The slide box loading module loads slide boxes. The slide box moving module includes a multi-functional pushing mechanism for horizontally pushing slides and a slide box moving mechanism. These mechanisms push the slides to the slide scanning module for scanning and detection. The visual recognition module acquires and numbers images of the slides to be scanned. The slide box recycling module collects scanned slides. While this patented technology can automatically load and inspect slides in batches, improving efficiency, it relies on an additional slide box moving module to transport slides between the loading, scanning, and recycling modules, failing to fully utilize the microscope's stage. Its complex structure makes manufacturing difficult and costly.

[0005] To overcome the above problems, a cervical cancer slide scanning device and its working method are needed. Summary of the Invention

[0006] The purpose of this invention is to provide a cervical cancer slide scanning device and its working method. Through continuous automatic loading and unloading, the scanning efficiency of the microscope is greatly improved, and the structure is relatively simple, making full use of the stage and reducing manufacturing costs.

[0007] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0008] This invention discloses a cervical cancer slide scanning device for scanning and screening cervical cancer sample slides. It includes an electron microscope and a stage, wherein the stage is a motorized stage comprising an X-axis motion component and a Y-axis motion component. The device also includes:

[0009] A base is provided for supporting the electron microscope and the stage, which are placed in the middle of the top platform plate of the base.

[0010] A front compartment mechanism is located on the right side of the stage. The front compartment mechanism has a vertically arranged front compartment chamber. Multiple slide trays that need to be scanned and screened are stacked in the front compartment chamber. The bottom of the front compartment chamber is provided with an ejection component for pushing a single slide tray onto the stage.

[0011] The rear compartment mechanism is located on the left side of the stage. The rear compartment mechanism has a vertically arranged rear compartment chamber. Multiple glass slide trays that have completed scanning and screening are stacked in the rear compartment chamber. The bottom of the rear compartment chamber is provided with a rear compartment bottom mechanism for pulling a single glass slide tray from the stage.

[0012] This application's technical solution primarily addresses the low efficiency of cervical cytology screening by employing automated scanning to replace manual screening. This significantly reduces the need for highly skilled cytopathologists, resolving a major industry pain point. It is particularly suitable for screening large batches of medical examination samples.

[0013] Furthermore, a stage top plate is horizontally provided on the top of the stage, and a guide groove that runs through the left and right sides is provided in the center of the top surface of the stage top plate. The width of the slide tray is adapted to the width of the guide groove. Multiple loading grooves are provided on the top surface of the slide tray, and the cervical cancer sample slide can be placed into the loading groove and locked by a spring-loaded foot at one end.

[0014] Furthermore, the top plate of the stage is provided with a spring clip mounting hole for mounting the spring clip, and a side groove is provided on the side wall of the slide tray. The spring clip can push against the end wall of the slide tray and the narrow end wall of the side groove to position and clamp the slide tray into the guide groove.

[0015] Furthermore, two guide strips are centrally located on the bottom surface of the guide groove, and a bottom sliding groove is centrally located on the bottom surface of the slide tray, which guides the slide to slide on the guide strips.

[0016] The shape and structure of the slide tray and the corresponding guide groove and spring clip are the key improvements of this application, ensuring accurate installation, smooth flow, and efficient operation.

[0017] Furthermore, the front compartment mechanism also includes a front compartment seat, a first C-shaped baffle, and a second C-shaped baffle. The front compartment seat is fixedly connected to the top platform plate of the base. The first C-shaped baffle and the second C-shaped baffle are vertically arranged and fixed face-to-face on the top of the front compartment seat. The first C-shaped baffle has a discharge port at its bottom end facing the right port of the guide groove.

[0018] This semi-open front compartment mechanism is easy to implement. Furthermore, the top-opening front compartment chamber and the opening on the side wall for placing an arm facilitate film placement and observation.

[0019] Furthermore, the ejection assembly includes a base frame, an ejection motor, a guide rod, a lead screw, an ejection slider, and a push block. The base frame is fixedly connected to the top platform plate of the base and located on the bottom surface of the front chamber. The ejection motor is mounted on the right end plate of the base frame. The guide rod and the lead screw are arranged parallel between the end plates of the base frame. The output shaft of the ejection motor is coaxially connected to the lead screw. The lead screw drives the ejection slider to move left and right along the guide rod. The push block is mounted on the top of the ejection slider and can push the glass slide tray, which is mounted on the lowest position of the receiving protrusion on the inner side wall of the front chamber, toward the discharge port. The rear part of the top of the push block is chamfered.

[0020] Furthermore, a tail groove is provided in the center of the right end of the slide tray, and the width of the push block is adapted to the tail groove; the inner wall of the second C-shaped baffle is set as an inclined baffle wall, the bottom end of the inclined baffle wall is inclined inward, and the two ends of the inclined baffle wall are provided with snap-fit ​​grooves, and the protruding heads at both ends of the tail groove are snapped into the snap-fit ​​grooves.

[0021] Furthermore, the rear compartment mechanism also includes a rear compartment seat and a third C-shaped baffle. The rear compartment seat is fixedly connected to the top platform plate of the base. The two third C-shaped baffles are vertically arranged and fixed face to face on the top of the rear compartment seat. The third C-shaped baffle on the right side has an inlet at its bottom end facing the left port of the guide groove.

[0022] Furthermore, the rear compartment bottom mechanism includes a pull-in component, a lifting component, and a first proximity switch. The working end of the pull-in component can pull the hook hole at the front end of the slide tray. The lifting component can lift the slide trays stacked in the rear compartment cavity to allow the working end of the pull-in component to reset to its original height. The first proximity switch feeds back the height signal of the lowest slide tray to the electronic control system of the equipment.

[0023] The present invention also discloses a working method of a cervical cancer slide scanning device, which uses the cervical cancer slide scanning device described in any of the above claims to perform scanning and screening of a large number of cervical cancer sample slides. The slide trays are stacked in the front chamber, and automatic loading and unloading improves the efficiency of operation.

[0024] Compared with the prior art, the beneficial technical effects of the present invention are as follows:

[0025] This invention relates to a cervical cancer slide scanning device. By positioning the front and rear compartment mechanisms on the right and left sides of the stage, respectively, a single stack of slides needs to be placed into the front compartment for scanning and then removed from the rear compartment in one go. This creates a unidirectional material flow from right to left, ensuring smooth and efficient sample transport. This cervical cancer slide scanning device significantly improves microscope scanning efficiency through continuous automatic loading and unloading, while maintaining a relatively simplified structure, fully utilizing the stage, and resulting in low manufacturing costs.

[0026] Furthermore, a through-flow guide groove on the top surface of the stage allows for smooth connection with the front and rear chamber mechanisms. Four sets of spring clips and spring clip blocks symmetrically arranged on both sides of the guide groove position and clamp the pushed-in slide trays, facilitating scanning observation with an electron microscope. The bottom slide groove and guide strip work together to achieve precise left-right positioning, enabling accurate zonal scanning of the sample slides. The addition of a chamfered angle allows for smooth entry into the guide groove during left-right movement. The front chamber, formed by the face-to-face interaction of the first and second C-shaped baffles, provides omnidirectional positioning and loading of the slide trays at all four corners. The openings on the front and rear side walls between the two baffles allow for easy access for the operator's arms, enhancing operational convenience. The ejection assembly uses a screw-slider structure to achieve linear reciprocating motion of the ejector block, resulting in high displacement control precision. The chamfered rear end of the ejector block allows for upward pushing of the stacked slide trays during rearward reset. By adapting the push block to the width of the tail groove, the forward and backward swaying of the slide tray during its ejection from the discharge port is reduced. The inclined baffle and locking groove ensure that the push block accurately enters the tail groove of the lowest slide tray at the initial push position. Furthermore, the inclined baffle allows for a slight left-right offset between slide trays stacked at different heights within the front chamber, facilitating smooth separation of the lowest slide tray from its adjacent upper counterpart. The smooth pulling of the slide tray is achieved through the coordinated action of the pull-in and lifting components. The hook strip and hook hole enable a detachable connection between the pull-in component and the slide tray. The L-shaped hook hole requires movement along the X and Y axes of the stage to engage the hook strip. Vertical guidance via guide blocks and guide columns allows for vertical movement of the U-shaped frame. By adding a camera, the ID number of the slide tray on the platform can be captured, allowing the equipment's electronic control system to record it and achieve traceability. The addition of a third proximity switch improves safety; the equipment stops operating when human intervention is detected. Attached Figure Description

[0027] The present invention will be further described below with reference to the accompanying drawings.

[0028] Figure 1 This is a three-dimensional structural diagram of the cervical cancer slide scanning device of the present invention;

[0029] Figure 2 This is a schematic diagram of the main structure of the cervical cancer slide scanning device of the present invention;

[0030] Figure 3 This is a top view schematic diagram of the cervical cancer slide scanning device of the present invention;

[0031] Figure 4This is a schematic diagram of the main cross-sectional structure of the cervical cancer slide scanning device of the present invention;

[0032] Figure 5 This is a three-dimensional structural diagram of the top plate of the platform of the present invention;

[0033] Figure 6 This is a three-dimensional structural diagram of the ejection component of the present invention;

[0034] Figure 7 This is a three-dimensional structural diagram of the rear compartment bottom mechanism of the present invention;

[0035] Figure 8 This is a schematic diagram of the three-dimensional structure of the slide tray of the present invention.

[0036] Explanation of reference numerals in the attached drawings: 1. Base; 101. Support leg; 2. Electron microscope; 3. Stage; 301. Stage top plate; 3011. Guide slot; 3012. Guide strip; 3013. Right slot opening; 3014. Left slot opening; 3015. Spring clip mounting hole; 4. Front compartment seat; 401. Receiving protrusion; 5. First C-shaped baffle; 6. Second C-shaped baffle; 601. Snap-fit ​​groove; 602. Sloping baffle wall; 7. Ejection assembly; 701. Base frame; 702. Ejection motor; 703. Guide rod; 704. Lead screw; 705. Ejection slider; 706. Push block; 707. Limit switch; 8. Rear compartment seat; 9. Rear compartment Bottom mechanism; 901, Pull-in assembly; 9011, Pull-in motor; 9012, Pull-in slider; 9013, Hook bar; 902, Lifting assembly; 9021, Guide sleeve block; 9022, Guide column; 9023, Bottom fixing seat; 903, First proximity switch; 10, Third C-shaped plate; 11, Front compartment chamber; 12, Rear compartment chamber; 13, Camera; 14, Light source; 15, Second proximity switch; 16, Third proximity switch; 17, Slide tray; 171, Loading groove; 172, Spring-loaded foot; 173, Side groove; 174, Tail groove; 175, Hook hole; 176, Bottom slide groove; 177, Beveled corner. Detailed Implementation

[0037] The core of this invention is to provide a cervical cancer slide scanning device and its working method. Through continuous automatic loading and unloading, the scanning efficiency of the microscope is greatly improved, and the structure is relatively simple, making full use of the stage and resulting in low manufacturing cost.

[0038] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0039] In the description of this invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0040] Refer to the attached diagram. Figure 1 This is a three-dimensional structural diagram of the cervical cancer slide scanning device of the present invention; Figure 2 This is a schematic diagram of the main structure of the cervical cancer slide scanning device of the present invention; Figure 3 This is a top view schematic diagram of the cervical cancer slide scanning device of the present invention; Figure 4 This is a schematic diagram of the main cross-sectional structure of the cervical cancer slide scanning device of the present invention; Figure 5 This is a three-dimensional structural diagram of the top plate of the platform of the present invention; Figure 6 This is a three-dimensional structural diagram of the ejection component of the present invention; Figure 7 This is a three-dimensional structural diagram of the rear compartment bottom mechanism of the present invention; Figure 8 This is a schematic diagram of the three-dimensional structure of the slide tray of the present invention.

[0041] In one specific implementation, such as Figures 1-8 As shown, the cervical cancer slide scanning device of the present invention is used for scanning and screening cervical cancer sample slides, especially suitable for screening large numbers of samples. The cervical cancer slide scanning device of the present invention includes an electron microscope 2 and a stage 3. The stage 3 is a motorized stage including an X-axis motion component and a Y-axis motion component. The lens assembly of the electron microscope 2 can move up and down along its own Z-axis motion component to achieve automatic focusing. The electron microscope 2 and the stage 3 in this part are prior art, and there are many similar devices on the market; therefore, they will not be described in detail here.

[0042] The key innovations of this invention are, for example Figures 1-4 As shown, the cervical cancer slide scanning device of the present invention further includes:

[0043] The base 1 supports the electron microscope 2 and the stage 3, which are positioned in the middle of the top platform plate of the base 1. Specifically, the bottom of the top platform plate has four leveling feet 101 at its four corners, and the top of the feet 101 is connected to the threaded holes at the corners of the top platform plate by screws.

[0044] The front chamber mechanism is located on the right side of the stage 3. The front chamber mechanism has a vertically arranged front chamber 11, in which multiple glass slide trays 17 to be scanned and screened are stacked. That is, the front chamber 11 is a sample placement chamber. The bottom of the front chamber 11 is provided with an ejection component 7 for pushing single glass slide trays 17 onto the stage 3.

[0045] The rear chamber mechanism is located on the left side of the stage 3. The rear chamber mechanism has a vertically arranged rear chamber 12, in which multiple glass slide trays 17 that have completed scanning and screening are stacked. That is, the rear chamber 12 is a sample collection chamber after testing. The bottom of the rear chamber 12 is provided with a rear chamber bottom mechanism 9 for pulling in a single glass slide tray 17 from the stage 3.

[0046] By positioning the front and rear chamber mechanisms on the right and left sides of the stage 3, a single stack of slide trays 17 can be placed into the front chamber 11 for scanning and then removed from the rear chamber 12. This creates a unidirectional material flow from right to left, ensuring smooth and efficient sample transport. This cervical cancer slide scanning device significantly improves microscope scanning efficiency through continuous automatic loading and unloading, while maintaining a relatively simple structure, fully utilizing the stage, and resulting in low manufacturing costs.

[0047] In one specific embodiment of the present invention, such as Figures 1-5 and Figure 8 As shown, a stage 3 has a horizontally mounted stage top plate 301. Driven by the X-axis and Y-axis motion components, the stage top plate 301 can move along the X and Y axes. A slide tray 17 is held on the stage top plate 301. A through-slot 3011 is centrally located on the top surface of the stage top plate 301, and the width of the slide tray 17 is adapted to the through-slot 3011. Multiple parallel loading grooves 171 are formed on the top surface of the slide tray 17, allowing the cervical cancer sample slides to be horizontally placed within the loading grooves 171 and secured by a spring-loaded foot 172 at one end. The slide tray 17 is made of plastic, and the spring-loaded foot 172 is also made of elastic plastic.

[0048] Specifically, such as Figure 5 and Figure 8 As shown, the top plate 301 of the stage is provided with spring clip mounting holes 3015 for mounting spring clips. The spring clips and spring clip blocks are installed with screws and are not shown in the attached drawings. The spring clips are formed by bending stainless steel strips. There are a total of four sets of spring clips and spring clip blocks on the top plate 301 of the stage, which are respectively arranged on both sides of the guide groove 3011. The side wall of the slide tray 17 is provided with a side groove 173. The spring clips can push against the end wall of the slide tray 17 and the narrow end wall of the side groove 173 to position and clamp the slide tray 17 into the guide groove 3011.

[0049] Specifically, such as Figure 5 and Figure 8 As shown, two guide bars 3012 are centrally located on the bottom surface of the guide groove 3011, and a bottom sliding groove 176 is centrally located on the bottom surface of the slide tray 17, which slides horizontally. The bottom sliding groove 176 slides along the guide bars 3012.

[0050] Specifically, such as Figure 5 and Figure 8 As shown, the long sidewalls of the slide tray 17 are provided with chamfered corners 177 at both ends.

[0051] By creating a through-slot 3011 on the top surface of the stage top plate 301, it can smoothly connect with the front and rear compartment mechanisms. By symmetrically arranging four sets of spring clips and spring clip blocks on both sides of the through-slot 3011, the pushed-in slide tray 17 can be positioned and secured, facilitating scanning observation by the electron microscope 2. The cooperation of the bottom sliding groove 176 and the guide strip 3012 enables precise left-right positioning, facilitating accurate zonal scanning of the sample slides. The addition of a chamfered angle 177 allows for smooth entry into the through-slot 3011 during left-right movement.

[0052] In one specific embodiment of the present invention, such as Figures 1-4 As shown, the front compartment mechanism also includes a front compartment seat 4, a first C-shaped baffle 5, and a second C-shaped baffle 6. The front compartment seat 4 is fixedly connected to the top platform plate of the base 1 using screws and corner blocks. The first C-shaped baffle 5 and the second C-shaped baffle 6 are vertically arranged and fixed face-to-face on the top of the front compartment seat 4. The first C-shaped baffle 5 has a discharge port at its bottom end facing the right port of the guide groove 3011.

[0053] Specifically, such as Figures 1-4 and Figure 6 As shown, the ejection assembly 7 includes a base frame 701, an ejection motor 702, a guide rod 703, a lead screw 704, an ejection slider 705, and a push block 706. The base frame 701 is fixedly connected to the top platform plate of the base 1 by screws and is located on the bottom surface of the front chamber 11. The ejection motor 702 is mounted on the right end plate of the base frame 701. The guide rod 703 and the lead screw 704 are arranged parallel to each other between the end plates of the base frame 701, with the lead screw 704 positioned between the two guide rods 703. The output shaft of the ejection motor 702 is coaxially connected to the lead screw 704. The lead screw 704 is threaded into the threaded hole in the middle of the ejection slider 705, driving the ejection slider 705 to move left and right along the guide rod 703. The push block 706 is mounted on top of the ejection slider 705 and can push the lowest position glass slide tray 17, which is mounted on the receiving protrusion 401 on the inner side wall of the front chamber 4, towards the discharge port. Furthermore, the rear of the top end of the push block 706 is chamfered.

[0054] Specifically, such as Figure 4 As shown, the receiving protrusions 401 are divided into two parts, left and right, on the inner wall of the front compartment 4 on one side. Each receiving protrusion 401 has a stepped shape with the right side higher than the left. When the slide tray 17 is pushed out by the pusher 706 at the lowest position, it can be separated from the adjacent slide tray 17 above by the yielding and falling of the side groove 173, reducing the pushing resistance. The adjacent slide tray 17 above is abutted by the top edge of the discharge port and cannot be conveyed backward.

[0055] Obviously, the ejection component 7 can also be implemented using a guided linear motor or electric actuator, that is, by using a linear motor or electric actuator to reciprocately push and pull out the slider 705 and the push block 706. Similar simple substitutions all fall within the protection scope of this invention.

[0056] Specifically, such as Figure 6 As shown, the ejection assembly 7 also includes a limit switch 707, which is installed on the top surface of the base frame 701 near the discharge port. A trigger baffle for triggering the limit switch 707 is provided at the bottom end of the ejection slider 705. The limit switch 707 feeds back the position signal of the leftmost end of the ejection slider 705 to the electrical control system of the equipment.

[0057] Specifically, such as Figure 5 , Figure 6 and Figure 8 The slide tray 17 has a centrally located tail groove 174 at its right end, and the width of the pusher 706 is adapted to the tail groove 174. The inner wall of the second C-shaped baffle 6 is configured as an inclined baffle 602, with the bottom end of the inclined baffle 602 sloping inward. The two ends of the inclined baffle 602 are provided with locking grooves 601, and the protruding heads at both ends of the tail groove 174 are engaged in the locking grooves 601.

[0058] Specifically, such as Figure 5 As shown, a right slot 3013 is provided in the center of the right end of the top plate 301 of the stage, and the push block 706 can move to the right slot 3013.

[0059] The front chamber 11, formed by the face-to-face interaction of the first C-shaped baffle 5 and the second C-shaped baffle 6, allows for omnidirectional loading and positioning of the four corners of the slide tray 17. Furthermore, the openings on the front and rear side walls between them facilitate the movement of the operator's arms, making operation more convenient. The ejection assembly 7 employs a screw-slider structure to achieve the left-right linear reciprocating motion of the push block 706, resulting in high displacement control precision. The chamfered rear end of the push block 706 allows for upward pushing of the stacked slide trays 17 during rearward reset. The width of the push block 706 is adapted to the tail groove 174, reducing the front-to-back swaying of the slide tray 17 during ejection from the discharge port. The inclined baffle 602 and the snap-fit ​​groove 601 ensure that the pusher 706 accurately enters the tail groove 174 of the lowest slide tray 17 at the starting position of the push. Moreover, the inclined baffle 602 allows the slide trays 17 stacked at different heights in the front chamber 11 to be slightly offset from left to right, which facilitates the smooth separation of the lowest slide tray 17 from the adjacent slide tray 17 above.

[0060] In one specific embodiment of the present invention, such as Figures 1-4 As shown, the rear compartment mechanism also includes a rear compartment seat 8 and a third C-shaped baffle 10. The rear compartment seat 8 is fixedly connected to the top platform plate of the base 1 using screws and corner blocks. The two third C-shaped baffles 10 are vertically arranged and fixed face-to-face to the top of the rear compartment seat 8 using screws. The third C-shaped baffle 10 on the right side has an inlet at its bottom end facing the left port of the guide groove 3011.

[0061] Specifically, such as Figures 1-4 As shown, weight-reducing holes are provided on the middle sidewalls of the first C-shaped baffle 5, the second C-shaped baffle 6, and the third C-shaped baffle 10. There are multiple weight-reducing holes, which are arranged at equal intervals along the height direction. The condition of the slide trays 17 inside the front chamber 11 and the rear chamber 12 can also be observed from the positions of these weight-reducing holes.

[0062] Specifically, such as Figures 1-4 and Figure 7 As shown, the rear compartment bottom mechanism 9 includes a pull-in component 901, a lifting component 902, and a first proximity switch 903 located at the bottom of the rear compartment chamber 12. The working end of the pull-in component 901 can pull the hook hole 175 at the front end of the slide tray 17, and the hook hole 175 adopts an L-shaped opening. The lifting component 902 can lift the slide trays 17 stacked in the rear compartment chamber 12 upward to make room for the passage height when the working end of the pull-in component 901 is reset. The first proximity switch 903 feeds back the height signal of the lowest slide tray 17 to the electronic control system of the equipment.

[0063] Specifically, such as Figure 7As shown, the pull-in assembly 901 includes a pull-in base frame, a pull-in motor 9011, a pull-in slider 9012, and a pull hook 9013. The pull-in base frame is equipped with a lead screw and a guide rod. The guide rod guides the pull-in slider 9012 left and right. The lead screw is driven by the pull-in motor 9011 at its left end, causing the pull-in slider 9012 to move left and right along the guide rod. The pull hook 9013 is centrally mounted on the right end of the top surface of the pull-in slider 9012 and can be hooked into the hook hole 175.

[0064] Specifically, such as Figure 5 As shown, a left slot 3014 is provided in the center of the left end of the top plate 301 of the platform, and the hook bar 9013 can move into the left slot 3014.

[0065] Specifically, such as Figure 7 As shown, the lifting assembly 902 includes a U-shaped plate frame, guide sleeves 9021, guide posts 9022, and a bottom fixing seat 9023. The U-shaped plate frame is laid flat with its opening facing the feed inlet, and the opening end is chamfered. Two guide sleeves 9021 are respectively fixedly connected to the bottom of the two sides of the U-shaped plate frame. The bottom fixing seat 9023 is fixedly connected to the bottom surface of the rear chamber 12. Two or more guide posts 9022 are vertically fixedly connected to the bottom fixing seat 9023, and the guide posts 9022 are guided through the vertical guide holes of the guide sleeves 9021. A compression spring is provided between the bottom fixing seat 9023 and the guide sleeves 9021. An electromagnet is installed in the middle of the bottom fixing seat 9023. When the electromagnet is energized, it can attract the guide sleeves 9021 downward, so that the guide sleeves 9021 press down to compress the compression spring and contact the bottom fixing seat 9023.

[0066] The slide tray 17 can be smoothly pulled in by the coordinated action of the pull-in component 901 and the lifting component 902. The cooperation between the hook strip 9013 and the hook hole 175 enables a detachable connection between the pull-in component 901 and the slide tray 17. The hook hole 175, which has an L-shaped opening, requires movement of the X and Y axes of the stage 3 to engage the hook strip 9013. The vertical guidance of the guide block 9021 and the guide post 9022 enables the vertical up and down movement of the U-shaped frame.

[0067] In one specific embodiment of the present invention, such as Figures 1-4 As shown, the cervical cancer slide scanning device of the present invention also includes a camera 13 and a light source 14. The camera 13 is mounted on the housing of the electron microscope 2 and is positioned facing the stage 3. The camera 13 can collect the ID number of the slide tray 17 on the stage 3 and feed it back to the electronic control system of the device. The light source 14 is installed in the middle of the top platform plate of the base 1 below the central hole of the stage 3. The light source 14 illuminates the field of view below the objective lens of the electron microscope 2 from below.

[0068] In one specific embodiment of the present invention, such as Figures 1-4 As shown, the cervical cancer slide scanning device of the present invention also includes a second proximity switch 15 and a third proximity switch 16. The second proximity switch 15 is mounted on the left outer shell of the electron microscope 2, and can collect signals when the slide tray 17 is pulled away by the pull-in assembly 901. The third proximity switch 16 is mounted on the front side of the front compartment 4, and can collect signals when the operator's arm moves a stack of slide trays 17. The second proximity switch 15 and the third proximity switch 16 feed back corresponding signals to the equipment's electrical control system.

[0069] By adding camera 13, the ID number of the slide tray 17 on the stage 3 can be collected, facilitating corresponding recording by the equipment's electrical control system and achieving traceability. The safety performance is improved by the installation of the third proximity switch 16; the equipment stops operating when personnel are detected.

[0070] In summary, the cervical cancer slide scanning device of the present invention, by setting the front chamber mechanism and the rear chamber mechanism on the right and left sides of the stage 3, only requires placing the entire stack of slide trays 17 into the front chamber 11 once for scanning and screening, and then removing them all at once from the rear chamber 12. This enables a unidirectional material flow from right to left, ensuring smooth and efficient sample transport. The cervical cancer slide scanning device of the present invention, through continuous automatic loading and unloading, significantly improves the scanning efficiency of the microscope, and has a relatively simplified structure, making full use of the stage and resulting in low manufacturing costs. Furthermore, by opening a through-flow guide groove 3011 on the top surface of the stage top plate 301, it can smoothly receive the front and rear chamber mechanisms; by symmetrically arranging four sets of springs and spring clamps on both sides of the guide groove 3011, the pushed-in slide trays 17 can be positioned and clamped, facilitating scanning observation by the electron microscope 2. The cooperation of the bottom groove 176 and the guide bar 3012 enables precise left and right positioning, facilitating accurate zonal scanning of the sample slides. The addition of a chamfered corner 177 allows for smooth entry into the guide groove 3011 during left and right movement. The front chamber 11, formed by the face-to-face interaction of the first C-shaped baffle 5 and the second C-shaped baffle 6, provides omnidirectional positioning and loading of the slide tray 17 at all four corners. Furthermore, the openings on the front and rear side walls between the two baffles allow for easy access to the operator's arms, making operation more convenient. The ejection assembly 7 employs a screw-slider structure to achieve the left-right linear reciprocating motion of the push block 706, resulting in high displacement control precision. The chamfered corner at the rear top of the push block 706 allows for upward pushing of the stacked slide trays 17 during rearward reset. The width of the push block 706 is adapted to the tail groove 174, reducing the front-to-back swaying of the slide tray 17 during ejection from the discharge port. The inclined baffle 602 and the locking groove 601 ensure that the push block 706 accurately enters the tail groove 174 of the lowest slide tray 17 at the initial push position. Furthermore, the inclined baffle 602 allows the slide trays 17 stacked at different heights in the front chamber 11 to be slightly offset left and right, facilitating smooth separation of the lowest slide tray 17 from the adjacent slide tray 17 above. The smooth pulling of the slide tray 17 is achieved through the coordinated action of the pull-in component 901 and the lifting component 902. The engagement of the hook strip 9013 and the hook hole 175 enables a detachable connection between the pull-in component 901 and the slide tray 17. The hook hole 175, with its L-shaped opening, requires movement of the X and Y axes of the stage 3 to engage the hook strip 9013. The vertical guidance provided by guide block 9021 and guide column 9022 enables the U-shaped plate frame to move vertically up and down. The addition of camera 13 allows for the acquisition of the ID number of the slide tray 17 on the stage 3, facilitating corresponding recording by the equipment's electrical control system and ensuring traceability.The safety performance is improved by setting the third proximity switch 16, which stops the equipment when personnel operation is detected.

[0071] This invention also discloses a method for operating a cervical cancer slide scanning device. Using the cervical cancer slide scanning device in any of the above embodiments, a large number of cervical cancer sample slides are scanned and screened. A stack of slides is placed on a tray 17 in the front chamber 11, and automatic loading and unloading improves operational efficiency. Specifically, the method includes the following steps:

[0072] S1. Place the slide tray 17 to be scanned and screened, and start the equipment to complete the initialization. Place the stack of slide trays 17 from top to bottom into the front chamber 11 of the front chamber mechanism. Note that the protruding heads at both ends of the tail groove 174 are inserted into the locking groove 601, and the lowest slide tray 17 is placed on the receiving protrusion 401.

[0073] S2. Loading: Start the equipment. The push motor 702 drives the lead screw 704 to rotate, which in turn drives the push slider 705 and the push block 706 to move from right to left. The top left side of the push block 706 contacts the bottom surface of the tail groove 174 and pushes the lowest end of the slide tray 17 outward. The slide tray 17 falls down step by step as it moves on the receiving protrusion 401. It detaches from the upper slide tray 17 and is output from the discharge port, which is exactly level with the aligned guide groove 3011. The push block 706 continues to push to the left until the limit switch 707 is triggered. At this time, the slide tray 17 enters the middle of the guide groove 3011 and is positioned and locked by the spring piece.

[0074] Push block 706 retracts, and push motor 702 drives lead screw 704 to rotate in the opposite direction, driving push slider 705 and push block 706 to move from left to right to reset. The chamfer at the rear of the top of push block 706 can push the glass slide tray 17 at the lowest end of the front chamber 11 slightly upward.

[0075] S3. Scanning and screening: Driven by the X-axis motion assembly and the Y-axis motion assembly, the stage top plate 301 moves the slide tray 17 along the X-axis and Y-axis. First, the ID number position of the slide tray 17 is moved to directly below the camera 13 to complete the acquisition and recording of the ID number. Then, the electron microscope 2 starts working, sequentially scanning the four cervical cancer sample slides on the slide tray 17 in sections, and storing the scan images.

[0076] S4. Unloading: After scanning, the stage top plate 301 moves to the vicinity of the inlet. At this time, the opening position of the hook hole 175 is aligned with the push-out position of the pull hook 9013. The stage top plate 301 then moves backward to allow the pull hook 9013 to be hooked into the hook hole 175. The pull-in component 901 is activated, and the pull-in motor 9011 drives the pull-in slider 9012 to move from right to left. As a result, the pull hook 9013 pulls the glass slide tray 17 away from the spring and into the rear chamber 12 from the inlet. If there are stacked glass slide trays 17 in the rear chamber 12, the stacked glass slide trays 17 will be pushed upward.

[0077] When the lifting component 902 is activated, the U-shaped plate frame pushes the lowest end of the glass slide tray 17 upward, and the entire stack rises to a set height. At this time, the hook bar 9013 disengages from below the hook hole 175, and the pull-in motor 9011 drives the pull-in slider 9012 to move from left to right, thereby resetting the hook bar 9013 to the rightmost position.

[0078] While the pull-in component 901 is resetting, the top plate 301 of the stage moves to the receiving position of the discharge port and restarts steps S2 to S4, repeating the cycle until all glass slide trays 17 in the front chamber 11 are scanned and screened.

[0079] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on its differences from other embodiments. Similar or identical parts between embodiments can be referred to interchangeably. For the apparatus disclosed in the embodiments, since they correspond to the methods disclosed in the embodiments, the description is relatively simple; relevant parts can be referred to the method section.

[0080] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A cervical cancer slide scanning device for scanning and screening cervical cancer sample slides, comprising an electron microscope (2) and a stage (3), wherein the stage (3) is an electric stage including an X-axis motion component and a Y-axis motion component, characterized in that, Also includes: The base (1) is used to support the electron microscope (2) and the stage (3), and the electron microscope (2) and the electric stage (3) are placed in the middle of the top platform plate of the base (1); A front chamber mechanism is located on the right side of the stage (3). The front chamber mechanism has a vertically arranged front chamber chamber (11). Multiple slide trays (17) that need to be scanned and screened are stacked in the front chamber chamber (11). The bottom of the front chamber chamber (11) is provided with a push-out component (7) for pushing a single slide tray (17) to the stage (3). The push-out component (7) includes a push block (706). The push block (706) can push the lowest position of the slide tray (17) mounted on the bottom of the inner side wall of the front chamber chamber (11) towards the discharge port. The rear part of the top of the push block (706) is chamfered. The slide tray (17) has a centrally located tail groove (174) at the right end, and the width of the pusher (706) is adapted to the tail groove (174); the right side wall of the front chamber (11) is configured as a sloping baffle (602), the bottom end of the sloping baffle (602) is inclined inward, and the two ends of the sloping baffle (602) are provided with snap-fit ​​grooves (601), and the protruding heads at both ends of the tail groove (174) are snapped into the snap-fit ​​grooves (601); The rear compartment mechanism is located on the left side of the stage (3). The rear compartment mechanism has a vertically arranged rear compartment chamber (12). Multiple glass slide trays (17) that have completed scanning and screening are stacked in the rear compartment chamber (12). The bottom of the rear compartment chamber (12) is provided with a rear compartment bottom mechanism (9) for pulling a single glass slide tray (17) from the stage (3). The top of the stage (3) is horizontally provided with a stage top plate (301), and a guide groove (3011) that runs through the left and right sides is provided in the center of the top surface of the stage top plate (301). The width of the glass slide tray (17) is adapted to the width of the guide groove (3011). The slide tray (17) is provided with a hook hole (175) at the front end. The hook hole (175) adopts an L-shaped opening. The hook bar (9013) of the rear compartment bottom mechanism (9) can be hooked into the hook hole (175) with the cooperation of the platform (3). The top plate (301) of the platform has a right slot (3013) at the center of the right end, and the push block (706) can move into the right slot (3013); the top plate (301) of the platform has a left slot (3014) at the center of the left end, and the hook bar (9013) can move into the left slot (3014).

2. The cervical cancer slide scanning device according to claim 1, characterized in that: The top surface of the slide tray (17) has a plurality of loading grooves (171) arranged side by side, and the cervical cancer sample slide can be placed in the loading grooves (171) and held in place by the spring-loaded foot (172) at one end.

3. The cervical cancer slide scanning device according to claim 2, characterized in that: The top plate (301) of the stage is provided with a spring clip mounting hole (3015) for mounting the spring clip, and the side wall of the slide tray (17) is provided with a side groove (173). The spring clip can push against the end wall of the slide tray (17) and the narrow end wall of the side groove (173) to position and clamp the slide tray (17) into the guide groove (3011).

4. The cervical cancer slide scanning device according to claim 2, characterized in that: Two guide strips (3012) are provided in the center of the bottom surface of the guide groove (3011), and a bottom sliding groove (176) that runs through the left and right sides is provided in the center of the bottom surface of the slide tray (17). The bottom sliding groove (176) slides on the guide strips (3012).

5. The cervical cancer slide scanning device according to claim 2, characterized in that: The front compartment mechanism also includes a front compartment seat (4), a first C-shaped baffle (5), and a second C-shaped baffle (6). The front compartment seat (4) is fixedly connected to the top platform plate of the base (1). The first C-shaped baffle (5) and the second C-shaped baffle (6) are vertically arranged and fixed face to face on the top of the front compartment seat (4). The first C-shaped baffle (5) has a discharge port at the bottom end facing the right port of the guide groove (3011).

6. The cervical cancer slide scanning device according to claim 5, characterized in that, The ejection assembly (7) includes a base frame (701), an ejection motor (702), a guide rod (703), a lead screw (704), and an ejection slider (705). The base frame (701) is fixedly connected to the top platform plate of the base (1) and located on the bottom surface of the front compartment chamber (11). The ejection motor (702) is mounted on the right end plate of the base frame (701). The guide rod (703) and the lead screw (704) are arranged parallel between the end plates of the base frame (701). The output shaft of the ejection motor (702) is coaxially connected to the lead screw (704). The lead screw (704) drives the ejection slider (705) to move left and right along the guide rod (703). The push block (706) is mounted on the top of the ejection slider (705).

7. The cervical cancer slide scanning device according to claim 2, characterized in that: The rear compartment mechanism also includes a rear compartment seat (8) and a third C-shaped baffle (10). The rear compartment seat (8) is fixedly connected to the top platform plate of the base (1). The two third C-shaped baffles (10) are vertically arranged and fixed face to face on the top of the rear compartment seat (8). The third C-shaped baffle (10) on the right side has an inlet at the bottom end facing the left port of the guide groove (3011).

8. The cervical cancer slide scanning device according to claim 7, characterized in that: The rear compartment bottom mechanism (9) includes a pull-in component (901), a lifting component (902), and a first proximity switch (903). The working end of the pull-in component (901) can pull the hook hole (175) at the front end of the slide tray (17). The lifting component (902) can lift the slide tray (17) stacked in the rear compartment chamber (12) upward to allow the working end of the pull-in component (901) to reset. The first proximity switch (903) feeds back the height signal of the lowest slide tray (17) to the electrical control system of the equipment.

9. A method for operating a cervical cancer slide scanning device, characterized in that: Using the cervical cancer slide scanning device described in any one of claims 1 to 8, a large number of cervical cancer sample slides are scanned and screened. The slide trays (17) are stacked in the front chamber (11), and the automatic loading and unloading improves the efficiency of the operation.

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