Sample analyzer and cleaning assembly

Abstract

The embodiment of the invention provides a sample analyzer and a cleaning assembly, the sample analyzer comprises a dispensing device, a needle processing device, a cleaning device and a controller, the dispensing device comprises a pipetting needle, a needle moving mechanism and a power mechanism; the needle treatment device is used for treating attachments on the outer wall of the pipetting needle or attachments on the needle tip of the pipetting needle; the cleaning device comprises a first cleaning pool provided with a first liquid inlet and a first liquid supply component communicated with the first liquid inlet; the controller is used for controlling the needle moving mechanism to drive the pipetting needle to move to a first processing position and controlling the needle processing device to execute first processing operation on the pipetting needle, and the first processing operation is used for processing attachments on the outer wall of the pipetting needle or attachments on the needle point of the pipetting needle; after the first treatment operation is executed, the needle moving mechanism is controlled to drive the pipetting needle to move to the first cleaning pool, and the first liquid supply component is controlled to supply liquid to the first cleaning pool through the first liquid inlet so as to clean the outer wall of the pipetting needle.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical apparatuses, and particularly relates to a sample analyzer and a cleaning assembly. BACKGROUND

[0002] In a sample analyzer, a pipette needle is usually used to transfer samples and / or reagents, and therefore, in order to prevent the surface of the pipette needle from carrying a pollution source, the pipette needle needs to be cleaned, wherein cleaning of the outer wall of the pipette needle is an important part of pipette needle cleaning.

[0003] The outer wall cleaning method in the related art usually involves transferring the pipette needle into a cleaning pool, and then cleaning the outer wall of the pipette needle by using a cleaning liquid. However, due to differences in the liquid to be transferred, different to-be-transferred liquids have different effects on the outer wall cleaning of the pipette needle. Taking the liquid to be transferred as a sample as an example, in some use scenarios, the sample contains impurities such as fibrin, separation gel or mixed beads. These impurities usually have the characteristics of high adhesion or large size. After the pipette needle completes the sample transfer, the conventional outer wall cleaning method is not applicable, for example, the conventional outer wall cleaning method based on the fact that the impurities usually have high adhesion may cause incomplete cleaning of the outer wall of the pipette needle or the impurities with large size cleaned out of the pipette needle may easily cause the cleaning component to be blocked. SUMMARY

[0004] The main purpose of the embodiments of the present application is to provide a sample analyzer and a cleaning assembly, which aims to improve the cleaning effect of the outer wall of the sample needle, so as to improve the accuracy and reliability of the detection result of the sample analyzer.

[0005] In a first aspect, the embodiments of the present application provide a sample analyzer, comprising: a dispensing device configured to perform a dispensing operation of a sample and / or a reagent, wherein the dispensing device comprises a pipette needle, a needle moving mechanism and a power mechanism, the pipette needle is configured to transfer at least the sample, the needle moving mechanism is configured to drive the pipette needle to move, and the power mechanism is configured to provide power for the pipette needle to suck and discharge the sample; a needle processing device configured to process at least the adhering matter of the outer wall of the pipette needle or the adhering matter of the needle tip of the pipette needle, and the needle tip of the pipette needle is provided with a needle liquid discharge port configured to at least suck and discharge the sample; a cleaning device comprising a first cleaning pool and a first liquid supply component, the first cleaning pool is provided with a first liquid inlet, the first liquid supply component is communicated with the first liquid inlet, and the first liquid supply component is configured to supply liquid to the first cleaning pool through the first liquid inlet; a controller in communication connection with the needle moving mechanism, the needle processing device and the first liquid supply component, and configured to: controlling the needle moving mechanism to drive the pipetting needle to move to a first processing position, and controlling the needle processing device to perform a first processing operation on the pipetting needle, the first processing operation being used at least for processing attachments on the outer wall of the pipetting needle or attachments on the needle tip of the pipetting needle; After the first processing operation is completed, the needle moving mechanism is controlled to drive the pipetting needle to move from the first processing position to the first cleaning pool, and the first liquid supply component is controlled to supply liquid to the first cleaning pool through the first liquid inlet to clean the outer wall of the pipetting needle.

[0006] As can be seen from the above embodiments, the sample analyzer provided in the embodiments is provided with a needle processing device. Before the outer wall of the pipetting needle is cleaned, the needle processing device is used to perform a first processing operation on the pipetting needle to process attachments on the outer wall of the pipetting needle or attachments on the needle tip of the pipetting needle. In this way, the larger or more viscous attachments such as mixed beads, fibrin or separation gel attached to the outer wall or needle tip of the pipetting needle are cleaned, so that the pipetting needle does not transfer the attachments such as mixed beads, fibrin or separation gel to the cleaning device for cleaning, thereby preventing the cleaning device from being blocked.

[0007] Further, after the first processing operation is completed, the pipetting needle is transferred to the cleaning device and the outer wall of the pipetting needle is cleaned in the cleaning device, so that the cleaning effect of the outer wall of the pipetting needle is better.

[0008] In a second aspect, the embodiments of the present application also provide a sample analyzer, comprising: a dispensing device used for performing a dispensing operation of a sample and / or a reagent, wherein the dispensing device comprises a pipetting needle, a needle moving mechanism and a power mechanism, the pipetting needle is used to transfer the sample and / or the reagent, the needle moving mechanism is used to drive the pipetting needle to move, and the power mechanism is used to provide power for the pipetting needle to suck and discharge the sample and / or the reagent; a needle processing device used at least for processing attachments on the outer wall of the pipetting needle or attachments on the needle tip of the pipetting needle; a cleaning device used at least for providing cleaning liquid to clean the outer wall of the pipetting needle; a controller, the sample analyzer is provided with a first cleaning mode and a second cleaning mode, and the controller is used to: selecting one of a first cleaning mode and a second cleaning mode to clean the pipette tip, wherein in the first cleaning mode, the controller controls the needle moving mechanism to drive the pipette tip to move to a first processing position, controls the needle processing device to perform a first processing operation, controls the needle moving mechanism to drive the pipette tip to move to a first cleaning position after the first processing operation is completed, and controls the cleaning device to perform the first cleaning operation on the pipette tip located at the first cleaning position, the first processing operation being used at least to process attachments on the outer wall of the pipette tip or attachments on the tip of the pipette tip, the tip of the pipette tip being provided with a needle discharge port used at least to suck and discharge the sample; in the second cleaning mode, the controller controls the cleaning device to perform the first cleaning operation, the first cleaning operation being used to clean the outer wall of the pipette tip.

[0009] As can be seen from the above embodiments, the sample analyzer provided in the embodiments is provided with two different cleaning modes, and the cleaning operations performed on the pipette tip are different in different cleaning modes, thereby providing multiple adaptive cleaning modes for different pipette tip use scenarios, which helps to improve the cleaning effect of the pipette tip in different use scenarios. For example, in the case where attachments such as mixing beads, fibrin or separation gel are attached to at least one of the outer wall and the tip of the pipette tip, the first cleaning mode is selected to clean the pipette tip, so as to at least process the attachments on the outer wall of the pipette tip or the attachments on the tip of the pipette tip by the needle processing device, thereby avoiding the poor cleaning effect or even cleaning blockage of the attachments on the outer wall and the tip of the pipette tip in the conventional cleaning mode, and effectively improving the cleaning effect of the pipette tip.

[0010] In the case where no attachments such as mixing beads, fibrin or separation gel are attached to the outer wall and the tip of the pipette tip, the second cleaning mode is selected to perform the conventional cleaning on the pipette tip by the cleaning device, and the cleaning time or cleaning consumables corresponding to the first cleaning mode are greater than the cleaning time or cleaning consumables corresponding to the second cleaning mode, so that the adaptive cleaning mode is selected for different pipette tip use scenarios, thereby effectively saving the time cost and consumable cost of pipette tip cleaning while improving the cleaning effect of the pipette tip.

[0011] In a third aspect, the embodiments of the present application further provide a cleaning assembly applied to a sample analyzer, the sample analyzer being provided with a pipette tip used to transfer a sample and / or a reagent, and the cleaning assembly comprises: a needle processing device used to process attachments on the outer wall of the pipette tip or attachments on the tip of the pipette tip; a cleaning device used at least to provide cleaning liquid to clean the outer wall of the pipette tip.

[0012] As can be seen from the above embodiments, the cleaning assembly provided by the present application is provided with a needle processing device and a cleaning device, so that in the case that the outer wall and / or the needle tip of the pipetting needle is attached with mixed beads, fibrin or separation gel, etc., the needle processing device can at least process the attachment on the outer wall of the pipetting needle or the attachment on the needle tip of the pipetting needle, and then the cleaning device can clean the pipetting needle regularly. In the case that the outer wall and the needle tip of the pipetting needle are not attached with mixed beads, fibrin or separation gel, etc., the cleaning device can at least clean the pipetting needle regularly. Therefore, the cleaning method can be selected according to different application scenarios of the pipetting needle, so as to improve the cleaning effect of the pipetting needle and effectively save the time cost and consumable cost of the pipetting needle cleaning.

[0013] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the disclosure of the embodiments of the present application. BRIEF DESCRIPTION OF DRAWINGS

[0014] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed in the embodiment description will be briefly introduced below. Obviously, the drawings in the following description are some embodiments of the present application, and those skilled in the art can also obtain other drawings according to these drawings without creative labor.

[0015] Figure 1 A schematic structural block diagram of a sample analyzer provided by an embodiment of the present application is shown in the figure. Figure 2 A structural schematic diagram of a sample analyzer in an embodiment is shown in the figure. Figure 3 A structural schematic diagram of a dispensing device of a sample analyzer in an embodiment is shown in the figure. Figure 4 A structural schematic diagram of a cleaning device of a sample analyzer in an embodiment is shown in the figure. Figure 5 A structural schematic diagram of a needle processing device of a sample analyzer in an embodiment is shown in the figure. Figure 6 A structural schematic diagram of a needle processing device of a sample analyzer in another embodiment is shown in the figure. Figures 7-8 A structural schematic diagram of a needle processing device of a sample analyzer in another embodiment is shown in the figure. DETAILED DESCRIPTION

[0016] With reference to the drawings, the technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present application, but not all of them. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts are within the scope of the present application.

[0017] In the description of the present application, unless explicitly defined and limited, the terms "mounting", "connection", "connecting" should be understood in a broad sense, for example, can be fixed connection, can also be detachable connection, or integral connection; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be internal communication of two elements. For those of ordinary skill in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0018] The flowchart shown in the drawings is only an example and does not necessarily include all contents and operations / steps, nor does it necessarily execute in the order described. For example, some operations / steps can also be decomposed, combined or partially combined, so the actual execution order may be changed according to the actual situation.

[0019] Some embodiments of the present application will be described in detail below with reference to the drawings. The following embodiments and features in the embodiments can be combined with each other without conflict.

[0020] Please refer to Figure 1 The present application provides a sample analyzer 100 for analyzing a sample to be tested to obtain a corresponding analysis result.

[0021] In some embodiments, the sample analyzer 100 includes, but is not limited to, at least one of the following: a biochemical analyzer, an immune analyzer, a coagulation analyzer, a urine analyzer.

[0022] As Figure 1 The sample analyzer 100 includes a dispensing device 10, a sample device 20, a reagent device 30, a reaction device 40, a measuring device 80 and a controller 70.

[0023] The sample device 20 is used to provide a sample, and the reagent device 30 is used to provide a reagent for reacting with the sample. For example, the reagent device 30 is provided with a plurality of reagent placement positions for carrying reagent containers, and the reagent for reacting with the sample is stored in the reagent containers, wherein the reagent includes, but is not limited to, a chromogenic reagent, a diluent, a substrate solution, an enzyme-labeled reagent, a magnetic bead reagent, etc.

[0024] The dispensing device 10 is used to perform a dispensing operation of the sample and / or the reagent to dispense the sample and / or the reagent to a target container.

[0025] The reaction apparatus 40 is provided with at least one reaction position for placing a reaction container. This reaction container is used to receive samples and reagents and to provide a mixing space for the samples and reagents. The reaction container includes, but is not limited to, a reaction cup. For example, the sample analyzer 100 is provided with a sample aspiration position and a reagent aspiration position. During the sample and reagent mixing process, the dispensing device 10 aspirates the sample supplied by the sample device 20 and the reagent supplied by the reagent device 30, respectively, and dispenses the aspirated sample and reagent into the reaction container placed in the preset operating position, so that the sample and reagent mix within the reaction container to form a reaction solution. Optionally, the reaction apparatus 40 is also used to incubate the reaction solution formed by the mixture of samples and reagents.

[0026] The measuring device 80 is used to detect and analyze the reaction solution formed by mixing the sample and reagents to obtain detection data. For example, the measuring device 80 is used to measure the reaction solution in the reaction vessel to obtain the sample's detection data.

[0027] Optionally, the measuring device 80 includes a photometric mechanism for detecting the luminescence intensity of the reaction liquid to obtain the luminescence intensity of the reaction liquid. Then, using a calibration curve and the luminescence intensity, the concentration of the analyte in the sample is calculated. It is understood that the detection data acquired by the measuring device 80 can be either the luminescence intensity of the reaction liquid or the concentration of the analyte in the reaction liquid. That is, calculating the concentration of the analyte in the sample using a calibration curve and the luminescence intensity can be performed by the measuring device 80 or the controller 70; no limitation is made here. Optionally, the measuring device 80 is separately disposed around the reaction device 40.

[0028] In another embodiment, the measuring device 80 includes an electrical detection mechanism (e.g., an impedance measuring mechanism) or a detection mechanism based on other principles (e.g., an imaging measuring mechanism).

[0029] Skilled technicians should understand that Figure 1 This is merely an example of a sample analyzer 100 and does not constitute a limitation on the sample analyzer 100. The sample analyzer 100 may include components such as... Figure 1 The sample analyzer 100 may include more or fewer components, or combinations of certain components, or different components. It may also include input / output devices, network access devices, etc.

[0030] The sample analyzer 100 also includes a scheduling device (not shown), which is used to perform scheduling of the reaction vessel. Specifically, the scheduling device is used to move the target object in two-dimensional or three-dimensional space to achieve the scheduling of the target object. For example, the scheduling device grabs the target object and moves it in two-dimensional or three-dimensional space, or after the target object is placed in the scheduling position set on the scheduling device, the scheduling device moves the target object placed in the scheduling position in two-dimensional or three-dimensional space.

[0031] For example, the scheduling device schedules the reaction container to a sample site in the sample analyzer 100, so that the dispensing device 10 performs a sample dispensing operation on the reaction container placed in the sample site, or the scheduling device schedules the reaction container to a reagent site in the sample analyzer 100, so that the dispensing device 10 performs a reagent dispensing operation on the reaction container placed in the reagent site.

[0032] Referring to Figure 2 In some embodiments, the reaction device 40 has a support portion 401, and the support portion 401 is provided with at least one reaction site for placing a reaction container (e.g., a reaction cup 4011), which is used to receive a sample and a reagent and provide a reaction space for the sample and the reagent to mix to form a reaction liquid. For example, the reaction container receives the sample obtained from the sample device 20 and the reagent obtained from the reagent device 30 by the dispensing device 10, so that the sample and the reagent mix in the reaction container to form a reaction liquid.

[0033] Optionally, the support portion 401 of the reaction device 40 can be a reaction disc, which is a disc-shaped assembly provided with one or more reaction sites for placing reaction containers. The reaction disc can incubate the reaction liquid in the reaction containers and can rotate to drive the reaction containers placed in the reaction sites to rotate, so as to schedule the reaction containers in the reaction disc to a predetermined area, for example, to schedule the reaction containers in the reaction sites to a position for reagent dispensing. Figure 2

[0034] It can be understood that the reaction sites for carrying the reaction containers can be provided not only in the reaction disc of the reaction device 40, but also independently of the reaction disc of the reaction device 40. The reaction sites provided independently of the reaction disc means that the provision of the reaction sites does not interfere with the rotation of the reaction disc itself.

[0035] Referring to Figure 2 In some embodiments, the sample device 20 can include a sample delivery module (SDM) and a front-end track. The sample device 20 can also be a sample disc including a plurality of sample sites for placing sample tubes. The sample disc can schedule the samples to a corresponding position, for example, to a sample suction position for the dispensing device 10 to suck the samples, by rotating the disc-shaped assembly of the sample disc. The dispensing device 10 is used to suck the samples and discharge them to the reaction containers to be dispensed.

[0036] ​In some embodiments, the dispensing device 10 is used to perform the dispensing operation of the sample and / or reagent, so as to dispense the sample and / or reagent to the target container. For example, the dispensing device 10 sucks the sample supplied by the sample sucking device 20 and transfers the sample to the reaction container to be added, or the dispensing device 10 sucks the reagent supplied by the reagent sucking device 30 and transfers the reagent to the reaction container to be added.

[0037] Referring to Figure 3 In some embodiments, the dispensing device 10 comprises a sample dispensing mechanism 10a, wherein the sample dispensing mechanism 10a is used to suck the sample supplied by the sample sucking device 20 and transfer the sample to the preset position. For example, the sample sucking device 20 carries a sample tube containing the sample to be measured, and the sample dispensing mechanism 10a sucks the sample to be measured from the sample tube carried by the sample sucking device 20 and discharges the sample to the reaction container to be added.

[0038] The sample dispensing mechanism 10a comprises a sample needle 101, a first needle moving mechanism 102 and a first power mechanism 103. The first needle moving mechanism 102 is used to support and drive the sample needle 101 to move. For example, the sample needle 101 moves in two or three dimensions in space through the two or three dimensional first needle moving mechanism 102, so that the sample needle 101 can move to suck the sample carried by the sample sucking device 20.

[0039] The first power mechanism 103 is used to suck the sample through the sample needle 101. For example, the sample to be measured is the blood sample to be measured, the sample needle 101 moves into the sample tube carrying the blood sample on the sample sucking device 20 under the drive of the first needle moving mechanism 102, and sucks the blood sample to be measured under the drive of the first power mechanism 103, and delivers the blood sample to be measured into the reaction container in the reaction position of the reaction device 40, so that the blood sample to be measured sucked by the dispensing device 10 is mixed with the reagent provided by the reagent sucking device 30 in the reaction container.

[0040] As Figure 3 shown, in some embodiments, the first needle moving mechanism 102 comprises a support frame 1021 fixed on a support rod 1022, the support rod 1022 is vertically movable and rotatable, and the support frame 1021 is vertically movable and horizontally rotatable under the drive of the support rod 1022. The sample needle 101 is arranged on the support frame 1021 and can reach the target position under the drive of the support frame 1021. For example, the first needle moving mechanism 102 further comprises a driver 1023 for driving the support rod 1022 to move, such as a stepping motor, but is not limited thereto. Optionally, the sample needle 101 is detachably connected with the first needle moving mechanism 102, or fixedly connected.

[0041] Optionally, the first power mechanism 103 comprises a tube 1031 and a power assembly 1033, wherein the tube 1031 is used to transport fluid medium, one end of the tube 1031 is in communication with the pipette needle 101, and the other end is in communication with the power assembly 1033, so as to change the flow direction of the fluid medium in the tube 1031 under the action of the power assembly 1033, so that the pipette needle 101 can carry out sample and / or reagent transfer.

[0042] As shown in FIG. 1, in some embodiments, the dispensing device 10 further comprises a reagent dispensing mechanism 10b, and the reagent device 30 comprises a reagent carrying mechanism 301 for carrying reagent containers, and the reagent dispensing mechanism 10b of the dispensing device 10 is used to suck reagents in the reagent containers carried by the reagent device 30 and then provide the reagents to the reaction device 40. Figure 2

[0043] Optionally, the reagent carrying mechanism 301 can be a reagent disc, which is a disc-shaped assembly and has a plurality of positions for carrying reagent containers. The reagent carrying mechanism 301 can rotate and drive the reagent containers carried thereby to rotate, so as to rotate the reagent containers to a predetermined position, for example, a reagent suction position for being sucked by the reagent dispensing mechanism 10b. The number of the reagent carrying mechanism 301 can be one or more.

[0044] In some embodiments, the reagent dispensing mechanism 10b can comprise a reagent needle, a second needle moving mechanism, and a second power mechanism. The reagent needle can move in two or three dimensions in space through the two or three dimensional second needle moving mechanism, so that the reagent needle can move and cooperate with the second power mechanism to suck reagents carried by the reagent carrying mechanism 301, and move to a reaction container to be added with reagents and discharge the reagents to the reaction container.

[0045] In some embodiments, the second needle moving mechanism and the first needle moving mechanism 102 have the same structure, and / or the second power mechanism and the first power mechanism 103 have the same structure, which will not be described herein.

[0046] In some embodiments, the reagent dispensing mechanism 10b does not add reagents through the reagent needle, but adds reagents in a reagent tube to a reaction container through a special tube. In such embodiments, there is only the sample needle 101, but no reagent needle.

[0047] ​It can be understood that, according to different body fluids and different detection items, the sample and the reagent have different adding modes. For example, the sample and the reagent can be added by the sample needle 101, or the sample is added by the sample needle 101 and the reagent is added by the reagent needle, or only the sample is added by the sample needle 101 and the reagent is added by other means. That is, the sample dispensing mechanism 10a of the dispensing device 10 is used for transferring the sample and transferring the reagent, or the sample dispensing mechanism 10a of the dispensing device 10 is used for transferring the sample and the reagent dispensing mechanism 10b is used for transferring the reagent, or the sample dispensing mechanism 10a of the dispensing device 10 is used for transferring the sample, and the reagent is added to the reaction container by connecting the reagent container carrying the reagent to the special pipeline. Therefore, the sample needle 101 and / or the reagent needle are also called pipetting needles, that is, the pipetting needles at least include any one of the sample needle 101 and the reagent needle.

[0048] As described above, the dispensing device 10 includes pipetting needles (such as the sample needle 101 and the reagent needle), needle moving mechanisms (such as the first needle moving mechanism and the second needle moving mechanism), and power mechanisms (such as the first power mechanism and the second power mechanism). The pipetting needles are used to transfer the sample and / or the reagent. The needle moving mechanisms are used to drive the pipetting needles to move. The power mechanisms are used to provide power for the pipetting needles to suck and discharge the sample and / or the reagent.

[0049] As shown in FIG. 1, in some embodiments, the sample analyzer 100 further includes a cleaning assembly, which is used at least to clean the pipetting needles of the sample analyzer 100. Figure 1 The cleaning assembly includes a cleaning device 60 and a needle processing device 50. The cleaning device 60 is used at least to provide cleaning liquid to clean the outer wall of the pipetting needles (such as the sample needle 101 and the reagent needle). Optionally, the cleaning device 60 is also used to provide cleaning liquid to clean the inner wall of the pipetting needles.

[0050] The needle processing device 50 is used to process the attachments on the outer wall of the pipetting needles (such as the sample needle 101 and the reagent needle) or the attachments on the needle tip of the pipetting needles.

[0051] For example, in some scenarios, the outer wall and the needle tip of the pipetting needles are not attached with preset types of attachments such as fibrin, separation gel, or mixing beads, and only the outer wall of the pipetting needles needs to be cleaned. At this time, the pipetting needles can be cleaned by the cleaning device 60.

[0052] In some scenarios, the outer wall of the pipette needle, the tip of the pipette needle is attached with a preset type of attachment such as fibrin, separation gel or mixed beads. Only cleaning the pipette needle by the cleaning device 60 may result in poor cleaning effect of the pipette needle, and even may cause the cleaning device 60 to be blocked. At this time, the needle processing device 50 can be used to process the attachment on the outer wall of the pipette needle or the attachment on the tip of the pipette needle, and then the pipette needle can be cleaned by the cleaning device 60, or only the needle processing device 50 can be used to process the attachment on the outer wall of the pipette needle or the attachment on the tip of the pipette needle.

[0053] Please refer to Figure 4 In some embodiments, the cleaning device 60 comprises a first cleaning pool 601 and a first liquid supply component 602, wherein the first cleaning pool 601 forms a first cleaning cavity 6012 for inserting the pipette needle, the side wall of the first cleaning cavity 6012 is provided with at least one first liquid inlet 6011 and a first liquid outlet 6013 communicating with the first cleaning cavity 6012, the first liquid supply component 602 communicates with the first liquid inlet 6011 and is used to supply liquid to the first cleaning pool 601 through the first liquid inlet 6011, and the liquid in the first cleaning cavity 6012 can be discharged from the first cleaning cavity 6012 through the first liquid outlet 6013.

[0054] Optionally, the first liquid inlet 6011 provided on the side wall of the first cleaning cavity 6012 is at least two, and the at least two first liquid inlets 6011 are oppositely arranged on the side wall of the first cleaning pool 601, so that a jet flow is formed during the process of supplying liquid to the first cleaning cavity 6012 through the first liquid inlet 6011 by the liquid supply component, so as to better clean the target device in the first cleaning cavity 6012, such as the pipette needle.

[0055] Optionally, the first liquid inlet 6011 extends in a first direction, and the first cleaning cavity 6012 extends in a second direction, and the second direction and the first direction are arranged at an angle, so that the liquid flow emitted through the first liquid inlet 6011 has a larger width during the process of supplying liquid to the first cleaning cavity 6012 through the first liquid inlet 6011, which can better cover the outer surface in the width direction and enhance the cleaning effect of the outer surface of the pipette needle.

[0056] Optionally, the angle between the second direction and the first direction is less than 90 degrees.

[0057] In some embodiments, the pipette needle is provided with a needle liquid inlet and a needle liquid outlet, and the cleaning liquid can clean the inner wall of the pipette needle through the needle liquid inlet, and the liquid during the cleaning process is discharged through the needle liquid outlet. Optionally, the needle liquid outlet is arranged at the tip of the pipette needle.

[0058] For example, the cleaning device 60 further comprises a fourth liquid supply component 603, which is connected to the needle liquid inlet and used to supply liquid to the pipette needle through the needle liquid inlet to clean the inner wall of the pipette needle. Alternatively, the first liquid supply component 601 is connected to the needle liquid inlet of the pipette needle and used to supply liquid to the pipette needle through the needle liquid inlet to clean the inner wall of the pipette needle, and the liquid during the cleaning of the inner wall of the pipette needle (also referred to as waste liquid) is discharged through the needle liquid outlet. That is, the first liquid supply component 601 is connected to the needle liquid inlet of the pipette needle and used to supply liquid to the pipette needle through the needle liquid inlet and discharge the liquid during the cleaning of the inner wall of the pipette needle through the needle liquid outlet to clean the inner wall of the pipette needle.

[0059] For the convenience of explanation, the following embodiments of the present application take the pipette needle as an example to illustrate the sample needle 101, but the pipette needle can also be a reagent needle.

[0060] As shown in FIG. 1, when the sample needle 101 needs to be cleaned, the first needle moving mechanism 102 moves the sample needle 101 to the first cleaning pool 601, and the control device 70 controls the first liquid supply component 602 to transport cleaning liquid to the first cleaning cavity 6012 through the first liquid inlet 6011 to clean the sample needle 101 located in the first cleaning cavity 6012. Figure 4

[0061] The sample needle 101 is provided with a needle liquid inlet 1011 and a needle liquid outlet 1012, and the needle liquid outlet 1012 is arranged at the needle tip of the sample needle 101. When the sample needle 101 is cleaned, the first needle moving mechanism 102 moves the sample needle 101 to the first cleaning pool 601, and the control device 70 controls the fourth liquid supply component 603 to transport cleaning liquid to the needle liquid inlet 1011 of the sample needle 101, so that the cleaning liquid ejected from the needle liquid inlet 1011 cleans the inner wall of the sample needle 101, and the liquid during the cleaning of the inner wall of the sample needle 101 can be discharged from the sample needle 101 through the needle liquid outlet 1012, thereby completing the cleaning of the inner wall of the sample needle 101.

[0062] It can be understood that the sample needle 101 can be supplied with liquid by the same liquid supply component during the cleaning of the inner wall and the outer wall, or the liquid supply components used for the cleaning of the inner wall and the outer wall can be arranged independently, that is, the liquid supply component used for the cleaning of the inner wall of the sample needle 101 is different from the liquid supply component used for the cleaning of the outer wall. For example, the first liquid supply component 602 is connected to the first liquid inlet 6011 through a first pipeline to provide cleaning liquid to the first cleaning pool 601 through the first liquid inlet 6011. The first liquid supply component 602 is connected to the needle liquid inlet 1011 of the sample needle 101 through a second pipeline, and the liquid is discharged through the needle liquid outlet 1012 of the sample needle 101 to clean the inner wall of the sample needle 101.

[0063] ​Alternatively, the cleaning device 60 comprises a first liquid supply component 602 and a fourth liquid supply component 603. The first liquid supply component 602 is configured to supply cleaning liquid for cleaning the outer wall of the sample needle 101. That is, the first liquid supply component 602 is connected to the first liquid inlet 6011 by a pipe to supply cleaning liquid to the first cleaning pool 601 through the first liquid inlet 6011. The fourth liquid supply component 603 is configured to supply cleaning liquid for cleaning the inner wall of the sample needle 101. That is, the fourth liquid supply component 603 is connected to the needle liquid inlet 1011 of the sample needle 101 by a pipe and discharges liquid through the needle liquid outlet 1012 of the sample needle 101 to clean the inner wall of the sample needle 101.

[0064] Referring to Figure 5 In some embodiments, the needle processing device 50 comprises a second cleaning pool 501a and a second liquid supply component 502a. The second cleaning pool 501a forms a second cleaning cavity 5012a for insertion of a pipette needle. The sidewall of the second cleaning cavity 5012a is provided with at least one second liquid inlet 5011a and a second liquid outlet 5013a communicating with the second cleaning cavity 5012a. The second liquid supply component 502a communicates with the second liquid inlet 5011a and is configured to supply liquid to the second cleaning pool 501a through the second liquid inlet 5011a. The liquid in the second cleaning cavity 5012a can be discharged from the second cleaning cavity 5012a through the second liquid outlet 5013a. The inner diameter of the first cleaning cavity 6012 is a first inner diameter, and the inner diameter of the second cleaning cavity 5012a is a second inner diameter, and the second inner diameter is greater than the first inner diameter. Thus, after the second liquid supply component 502a supplies liquid to the second cleaning cavity 5012a through the second liquid inlet 5011a, the adhering objects such as mixed beads and fibrin adhering to the outer wall of the pipette needle and / or the needle tip are less likely to adhere to the inner wall of the second cleaning cavity 5012a after being cleaned by the liquid flow, thereby reducing the probability of clogging of the needle processing device 50. Optionally, the second inner diameter of the second cleaning cavity 5012a is at least twice the first inner diameter of the first cleaning cavity 6012. Optionally, the second liquid inlet 5011a provided on the sidewall of the second cleaning cavity 5012a is at least two, and the at least two second liquid inlets 5011a are oppositely arranged on the sidewall of the second cleaning pool 501a, thereby forming a jet flow during the process of supplying liquid to the second cleaning cavity 5012a by the liquid supply component through the second liquid inlet 5011a, so as to better clean the target device such as the pipette needle located in the second cleaning cavity 5012a.

[0065] Optionally, the second liquid inlet 5011a extends along a first direction, and the second cleaning cavity 5012a extends along a second direction, the second direction and the first direction are arranged at an angle, so that when the second liquid inlet 5011a supplies liquid to the second cleaning cavity 5012a, the liquid flow emitted by the second liquid inlet 5011a has a large width, which can better cover the outer surface in the width direction and enhance the cleaning effect of the outer surface of the pipette tip.

[0066] Optionally, the second liquid supply component 502a of the needle processing device 50 and the first liquid supply component 602 of the cleaning device 60 share the same power assembly, which includes but is not limited to at least one of a pump and a syringe, that is, the same power assembly can be connected to the second liquid inlet 5011a of the second cleaning cavity 5012a and the first liquid inlet 6011 of the first cleaning cavity 6012 through different pipelines. When the power assembly supplies liquid to the first cleaning cavity 6012, the first switch unit arranged on the first pipeline in communication with the first liquid inlet 6011 is controlled to make the channel through which the power assembly supplies liquid to the first cleaning cavity 6012 conductive, so that the power assembly can drive the cleaning liquid to flow to the first cleaning cavity 6012 through the first pipeline, thereby achieving liquid supply to the first cleaning cavity 6012. Similarly, when the power assembly supplies liquid to the second cleaning cavity 5012a, the second switch unit arranged on the second pipeline in communication with the second liquid inlet 5011a is controlled to make the channel through which the power assembly supplies liquid to the second cleaning cavity 5012a conductive, so that the power assembly can drive the cleaning liquid to flow to the second cleaning cavity 5012a through the second pipeline, thereby achieving liquid supply to the second cleaning cavity 5012a.

[0067] In some embodiments, the needle processing device 50 further comprises a filter 504, which is connected with the second cleaning pool 501a and arranged at the second liquid outlet 5013a, that is, the filter 504 is arranged corresponding to the second liquid outlet 5013a and connected with the second cleaning pool 501a. Optionally, the connection between the filter 504 and the second cleaning pool 501a is realized by means of detachable connection such as threaded connection, buckle connection, interference fit or pin connection.

[0068] In addition, the filter 504 can be directly detachably connected with the second cleaning pool 501a, or the filter 504 is detachably connected with an adapter, and the adapter is detachably connected with the second cleaning pool 501a, thereby indirectly realizing the detachable connection between the filter 504 and the second cleaning pool 501a.

[0069] Optionally, the filter 504 is formed with a filter cavity 5041, the inner diameter of the filter cavity 5041 is greater than or equal to the inner diameter of the second cleaning cavity 5012a, and after the outer wall attachments of the pipette tip and / or the tip attachments of the pipette tip are processed in the second cleaning cavity 5012a, the fallen attachments are not easy to block the second cleaning cavity 5012a.

[0070] In some embodiments, the needle processing device 50 further comprises a third liquid supply component 503a, which is in communication with the liquid inlet of the pipette needle and is configured to supply liquid to the pipette needle through the liquid inlet to discharge the adhering matter on the tip of the pipette needle into a preset container. Optionally, the third liquid supply component 503a and the first liquid supply component 602 are powered by the same power assembly, or the third liquid supply component 503a and the fourth liquid supply component 603 are powered by the same power assembly.

[0071] Referring to Figure 6 In some embodiments, the needle processing device 50 comprises a wiping component 501b and a recovery component 502b, the wiping component 501b is provided with a wiping member 5011b configured to wipe the pipette needle, and the recovery component 502b is configured to recover the adhering matter dropped from the pipette needle.

[0072] As Figure 6 illustrated, the pipette needle is taken as an example of the sample needle 101, but the pipette needle can also be a reagent needle.

[0073] During the process of the needle processing device 50 processing the adhering matter on the sample needle 101, the wiping component 501b and the sample needle 101 are controlled to have relative displacement, so that the wiping member 5011b of the wiping component 501b is in contact with the sample needle 101, and the adhering matter adhering to the outer wall or the tip of the sample needle 101 is separated from the sample needle 101 and dropped into the recovery component 502b or adheres to the wiping member 5011b, thereby achieving the processing of the adhering matter on the outer wall and / or the tip of the sample needle 101.

[0074] Referring to Figure 7 and Figure 8 In some embodiments, the needle processing device 50 further comprises an ultrasonic cleaning tank 501c and an ultrasonic generator 502c. The ultrasonic cleaning tank 501c is formed with an ultrasonic cleaning cavity 5011c for inserting the pipette needle, a third liquid inlet 5012c in communication with the ultrasonic cleaning cavity 5011c, and a third liquid outlet 5013c in communication with the ultrasonic cleaning cavity 5011c. The cleaning liquid can enter the ultrasonic cleaning cavity 5011c through the third liquid inlet 5012c, and the liquid in the ultrasonic cleaning cavity 5011c can be discharged through the third liquid outlet 5013c.

[0075] Optionally, the needle treatment device 50 further includes an overflow tank 503c, which is used to collect liquid overflowing from the ultrasonic cleaning chamber 501c, and the overflowing liquid is discharged through an overflow drain port 5031c provided in the overflow tank. For example, during ultrasonic cleaning, excess cleaning fluid may overflow from the top of the ultrasonic cleaning chamber 5011c into the overflow tank 503c, and then be discharged through the overflow drain port 5031c connected to the overflow tank 503c.

[0076] like Figure 7 and Figure 8 As shown, during the process of treating the deposits on the sample needle 101 by the needle treatment device 50, the sample needle 101 is placed in the ultrasonic cleaning chamber 5011c, and ultrasonic vibration is output by the ultrasonic generator 502c. The sample needle 101 is ultrasonically cleaned by the cleaning fluid in the ultrasonic cleaning chamber 5011c, thereby achieving the treatment of the deposits on the outer wall and / or the needle tip of the sample needle 101.

[0077] In some embodiments, the sample analyzer 100 further includes a needle detection device 90, which is used to detect whether there are any deposits on the outer wall of the pipette or the tip of the pipette, and outputs corresponding detection information so that the controller 70 can determine whether there are any deposits on the outer wall of the pipette or the tip of the pipette based on the detection information output by the needle detection device 90.

[0078] For example, a pipette is typically used to aspirate at least one of a sample, reagent, or reaction solution at a preset aspiration pressure. The pipette detection device 90 detects the pressure change of the pipette during the aspiration or dispensing process, and if the detected pressure is greater than a threshold, it indicates that the tip of the pipette may be blocked, and thus determines that there is deposited material on the tip of the pipette.

[0079] For example, the needle detection device 90 acquires an image of the pipette after it has aspirated a sample, performs image analysis on the image, and determines whether there are any attached substances on the outer wall or tip of the pipette in the acquired image, and outputs the corresponding detection information to the controller 70.

[0080] The controller 70 is communicatively connected to the dispensing device 10, sample device 20, reagent device 30, reaction device 40, needle detection device 90, cleaning device 60, and measuring device 80 to control at least one of the dispensing device 10, sample device 20, reagent device 30, reaction device 40, needle detection device 90, cleaning device 60, and measuring device 80 to perform preset operations, such as testing the sample to be tested or cleaning the target device.

[0081] Figure 1As shown, in some embodiments, the controller 70 can be one or more, and the controller 70 can be disposed in at least one of the dispensing device 10, the sample device 20, the reagent device 30, the reaction device 40, the needle detection device 90, the cleaning device 60, and the measuring device 80, or can be independently disposed, which is not limited herein.

[0082] Optionally, the controller 70 at least includes a processor 701, a memory 702, a communication interface (not shown in the figure), and an I / O interface (not shown in the figure). The processor 701, the memory 702, the communication interface, and the I / O interface communicate through a bus. The processor 701 can be a central processing unit (CPU), and the processor can also be other general-purpose processors, digital signal processors (DSPs), application-specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components, and the like. Among them, the general-purpose processor can be a microprocessor or the processor can also be any conventional processor and the like.

[0083] The memory 702 stores various computer programs and data required for executing the computer programs by the processor 701, such as an operating system and an application program. If necessary, data to be locally stored during the analysis of the to-be-tested sample can be stored in the memory 702. The I / O interface includes but is not limited to a serial interface such as a USB, an IEEE 1394, or an RS-232C, a parallel interface such as a SCSI, an IDE, or an IEEE 1284, and an analog signal interface composed of a D / A converter and a converter. An input component is connected to the I / O interface, and a user can directly input data to the controller 70 by using the input component, which includes but is not limited to a keyboard, a mouse, a touch screen, or a control button. A display component can be communicatively connected to the controller 70 through the I / O interface to prompt relevant information. The communication interface can be an interface of any known communication protocol, and the communication interface communicates with the outside through a network. The controller 70 can transmit data between any components connected through the network by using a preset communication protocol through the communication interface.

[0084] In some embodiments, the controller 70 is at least used to perform the following operations, specifically, the processor 701 of the controller 70 calls a computer program in the memory 702 to perform the following operations: controlling the needle moving mechanism to drive the pipetting needle to move to a first processing position, and controlling the needle processing device to perform a first processing operation on the pipetting needle, the first processing operation being used at least for processing the attachments on the outer wall of the pipetting needle or the attachments on the needle tip of the pipetting needle; After the first processing operation is performed, the controller controls the needle moving mechanism to drive the pipetting needle to move from the first processing position to the first cleaning pool, and controls the first liquid supply component to supply liquid to the first cleaning pool through the first liquid inlet to clean the outer wall of the pipetting needle.

[0085] For example, the pipetting needle is taken as the sample needle 101, and in the case that there are preset types of attachments such as fibrin, separation gel or mixed beads on the needle tip of the sample needle 101 or on the outer wall of the sample needle, or in the case that the user wants to process the sample needle 101 by using the needle processing device 50.

[0086] The controller 70 controls the first needle moving mechanism 102 to drive the sample needle 101 to move to a first processing position, and controls the needle processing device 50 to perform a first processing operation on the sample needle located at the first processing position, so as to process the preset types of attachments attached to the outer wall of the sample needle 101 and / or the preset types of attachments attached to the needle tip of the sample needle 101 by the first processing operation.

[0087] After the first processing operation is performed, the controller 70 controls the first needle moving mechanism 102 to drive the sample needle 101 to move from the first processing position to the first cleaning pool 601, and controls the first liquid supply component 602 to supply liquid to the first cleaning pool 601 through the first liquid inlet 6011 to clean the outer wall of the sample needle 101 located in the first cleaning pool 601.

[0088] As can be seen from the above embodiments, the sample analyzer is provided with the needle processing device 50, and before the pipetting needle is cleaned, the pipetting needle (such as the sample needle 101) is first processed by the needle processing device to perform a first processing operation, so as to process the attachments on the outer wall of the pipetting needle or the attachments on the needle tip of the pipetting needle (also referred to as the attachments on the needle tip), thereby cleaning the mixed beads, fibrin or separation gel and other relatively large or relatively viscous attachments attached to the outer wall or the needle tip of the pipetting needle, avoiding the pipetting needle transferring the mixed beads, fibrin or separation gel and other attachments to the cleaning device for cleaning, and causing the cleaning device 60 to be blocked. Further, after the first processing operation is performed, the pipetting needle is transferred from the first processing position to the cleaning device 60, and the outer wall of the pipetting needle is cleaned in the cleaning device 60, so that the cleaning effect of the outer wall of the pipetting needle is better.

[0089] As Figure 5As shown, in some embodiments, the needle processing device 50 comprises a second cleaning tank 501a and a second liquid supply component 502a, the second cleaning tank 501a is formed with a second cleaning cavity 5012a for insertion of the pipette needle, a second liquid inlet 5011a communicating with the second cleaning cavity 5012a, a second liquid outlet 5013a communicating with the second cleaning cavity 5012a, liquid in the second cleaning cavity 5012a can be discharged through the second liquid outlet 5013a, and the inner diameter of the second cleaning cavity 5012a is greater than the inner diameter of the first cleaning cavity, and the second liquid supply component 502a is configured to supply liquid to the second cleaning cavity 5012a through the second liquid inlet 5011a.

[0090] During the first processing operation performed by the needle processing device 50, the controller 70 is configured to control the second liquid supply component 502a to supply liquid to the second liquid inlet 5011a to clean the adhering substances on the outer wall of the pipette needle and / or the needle tip of the pipette needle located in the second cleaning cavity 5012a.

[0091] Alternatively, the needle processing device 50 and the cleaning device 60 share the first liquid supply component 602, and the needle processing device 50 comprises a second cleaning tank 501a, the second cleaning tank 501a is formed with a second cleaning cavity 5012a for insertion of the pipette needle, a second liquid inlet 5011a communicating with the second cleaning cavity 5012a, a second liquid outlet 5013a communicating with the second cleaning cavity 5012a, liquid in the second cleaning cavity 5012a can be discharged through the second liquid outlet 5013a, and the inner diameter of the second cleaning cavity 5012a is greater than the inner diameter of the first cleaning cavity, and the first liquid supply component 602 is in communication with the second liquid inlet 5011a and is configured to supply liquid to the second cleaning cavity 5012a through the second liquid inlet 5011a.

[0092] During the first processing operation performed by the needle processing device 50, the controller 70 is configured to control the first liquid supply component 602 to supply liquid to the second liquid inlet 5011a to clean the adhering substances on the outer wall of the pipette needle and / or the needle tip of the pipette needle located in the second cleaning cavity 5012a.

[0093] That is, in order to improve the cleaning effect of the outer wall of the pipette needle, the cleaning effect of the outer wall of the pipette needle is generally not too large between the inner wall of the first cleaning cavity and the pipette needle located in the first cleaning cavity, and therefore, the inner diameter of the first cleaning cavity is set in the first preset range, which can effectively improve the impact of the liquid flow discharged from the first liquid outlet on the outer wall of the pipette needle, thereby improving the cleaning effect of cleaning the outer wall of the pipette needle.

[0094] However, based on the small inner diameter of the first cleaning cavity, when the outer surface or the tip of the pipette needle has a larger or more viscous pre-set type of adherent such as a mixed bead, fibrin or a separation gel, if the pipette needle is directly transferred to the first cleaning pool 601 of the cleaning device 60 for cleaning, the mixed bead, fibrin or separation gel pre-set type of adherent may be separated from the pipette needle, and based on the close distance between the outer surface of the pipette needle and the inner wall of the first cleaning pool 601, the adherent may be attached to the inner wall of the first cleaning cavity, causing the first cleaning cavity to be blocked.

[0095] The inner diameter of the second cleaning cavity 5012a formed by the second cleaning pool 501a is larger than the inner diameter of the first cleaning cavity 6012 formed by the first cleaning pool 601, and therefore, during the cleaning process of the pre-set type of adherent on the outer wall or the tip of the pipette needle (such as a sample needle) in the second cleaning pool 5012a, the distance between the outer wall of the pipette needle and the inner wall of the second cleaning cavity 5012a is larger, and the adherent is not easy to stick to the inner wall of the second cleaning cavity, avoiding the situation that the pipette needle with the pre-set type of adherent is directly cleaned in the first cleaning pool 601, causing the first cleaning cavity to be blocked.

[0096] Please refer to Figure 6 In some embodiments, the needle processing device 50 includes a wiping component 501b, the wiping component 501b is provided with a wiping member 5011b for wiping the pipette needle, and the recovery component 502b is at least used for recovering the adherent attached to the pipette needle, such as the outer wall adherent and / or the tip adherent attached to the pipette needle.

[0097] The controller 70 performs the following operations during the process of controlling the needle processing device 50 to perform the first processing operation on the pipette needle: controlling the needle moving mechanism to drive the pipette needle to move towards the wiping component 501b, so that the pipette needle and the wiping member 5011b of the wiping component 501b are in contact; and controlling the needle moving mechanism and / or the wiping component 501b to perform a first processing action to wipe the outer wall adherent of the pipette needle and / or the tip adherent of the pipette needle by the wiping member 5011b; the first processing action includes one of the following: controlling the needle moving mechanism to drive the pipette needle to move relative to the wiping component 501b in the extension direction of the pipette needle; controlling the wiping component 501b to move relative to the pipette needle in the extension direction of the pipette needle; controlling the needle moving mechanism to drive the pipette needle to move in the extension direction of the pipette needle, and controlling the wiping component 501b to move in the extension direction of the pipette needle so that the pipette needle and the wiping member 5011b provided on the wiping component 501b move relative to each other at least in the extension direction of the pipette needle.

[0098] Alternatively, the controller 70 controls the wiping component 501b to move towards the pipette needle located at the first processing position so that the pipette needle and the wiper 5011b of the wiping component 501b are in contact, and controls the needle moving mechanism and / or the wiping component 501b to perform a first processing action to wipe the adherents on the outer wall of the pipette needle and / or the needle tip of the pipette needle by the wiper 5011b; the first processing action comprises one of the following: controlling the needle moving mechanism to drive the pipette needle to move relative to the wiping component 501b in the extension direction of the pipette needle; controlling the wiping component 501b to move relative to the pipette needle in the extension direction of the pipette needle; controlling the needle moving mechanism to drive the pipette needle to move in the extension direction of the pipette needle, and controlling the wiping component 501b to move in the extension direction of the pipette needle so that the pipette needle and the wiper 5011b provided on the wiping component 501b move relative to each other at least in the extension direction of the pipette needle.

[0099] For example, during the first processing operation performed by the needle processing device 50 on the sample needle 101, the first needle moving mechanism 102 drives the sample needle 101 located at the first processing position to move towards the wiping component 501b so that the sample needle 101 and the wiper 5011b of the wiping component 501b are in contact, and controls the first needle moving mechanism 102 and / or the wiping component 501b to perform a first processing action to wipe the adherents on the outer wall of the sample needle 101 and / or the needle tip of the sample needle 101 by the wiper 5011b, and the adherents (e.g. beads) fallen from the sample needle 101 can be collected by the collection component 502b.

[0100] Alternatively, the controller 70 controls the wiping component 501b to move towards the sample needle 101 located at the first processing position so that the sample needle 101 and the wiper 5011b of the wiping component 501b are in contact, and controls the first needle moving mechanism 102 and / or the wiping component 501b to perform a first processing action to wipe the adherents on the outer wall of the sample needle 101 and / or the needle tip of the sample needle 101 by the wiper 5011b, and the adherents (e.g. beads) fallen from the sample needle 101 can be collected by the collection component 502b.

[0101] The first processing action comprises one of the following: controlling the first needle moving mechanism 102 to drive the sample needle 101 to move relative to the wiping component 501b in the extension direction of the sample needle 101; controlling the wiping component 501b to move relative to the sample needle 101 in the extension direction of the sample needle 101; controlling the first needle moving mechanism 102 to drive the sample needle 101 to move in the extension direction of the sample needle 101, and controlling the wiping component 501b to move in the extension direction of the sample needle 101 so that the sample needle 101 and the wiper 5011b provided on the wiping component 501b move relative to each other at least in the extension direction of the sample needle 101.

[0102] Referring to Figures 7-8 In some embodiments, the needle processing device 50 comprises an ultrasonic cleaning tank 501c and an ultrasonic generator 502c, the ultrasonic cleaning tank 501c is formed with an ultrasonic cleaning cavity 5011c for inserting the pipette needle, a third liquid inlet 5012c communicating with the ultrasonic cleaning cavity 5011c, and a third liquid outlet 5013c communicating with the ultrasonic cleaning cavity 5011c, the cleaning liquid can enter the ultrasonic cleaning cavity 5011c through the third liquid inlet 5012c, and the liquid in the ultrasonic cleaning cavity 5011c can be discharged through the third liquid outlet 5013c; the first processing position is located in the ultrasonic cleaning tank 501c, and during the execution of the first processing operation by the needle processing device 50, the controller is configured to control the ultrasonic generator 502c to output ultrasonic vibration to perform ultrasonic cleaning on the adherend on the outer wall of the pipette needle and / or the adherend on the needle tip of the pipette needle in the ultrasonic cleaning tank 501c through the cleaning liquid in the ultrasonic cleaning tank 501c.

[0103] For example, when the sample needle 101 needs to perform the first processing operation by the needle processing device 50, the controller 70 controls the first pipette needle moving mechanism 102 to drive the sample needle 101 to move into the ultrasonic cleaning cavity 5011c of the ultrasonic cleaning tank 501c, so that the sample needle 101 is inserted into the cleaning liquid in the ultrasonic cleaning cavity 5011c, and controls the ultrasonic generator 502c to output ultrasonic vibration to perform ultrasonic cleaning on the adherend on the outer wall of the sample needle 101 and / or the adherend on the needle tip of the pipette needle in the ultrasonic cleaning tank 501c through the cleaning liquid in the ultrasonic cleaning tank 501c, that is, under the condition that the ultrasonic generator 502c outputs ultrasonic vibration, the ultrasonic vibration can be transmitted to the outer wall and the needle tip of the pipette needle through the cleaning liquid in the ultrasonic cleaning tank 501c, so that the adherend on the outer wall of the pipette needle falls off from the outer wall of the pipette needle, and / or the adherend on the needle tip of the pipette needle falls off from the needle tip of the pipette needle, thereby realizing ultrasonic cleaning of the adherend on the outer wall of the sample needle 101 and / or the adherend on the needle tip of the pipette needle.

[0104] Referring to Figure 3 In some embodiments, the sample analyzer 100 further comprises a needle detection device 90, the needle detection device 90 is in communication connection with the controller 70 and is configured to detect whether the adherend exists on the outer wall of the pipette needle and / or the needle tip of the pipette needle; before the controller 70 controls the needle moving mechanism to drive the pipette needle to move to the first processing position, the controller 70 is further configured to: receive the first detection information output by the needle detection device 90; When it is determined according to the first detection information that the outer wall of the pipette needle or the needle tip of the pipette needle has the attachment, the needle moving mechanism is controlled to drive the pipette needle to move to the first processing position, and the needle processing device 50 is controlled to perform the first processing operation on the pipette needle; after the first processing operation is completed, the needle moving mechanism is controlled to drive the pipette needle to move to the first cleaning pool 601, and the first liquid supply component 602 is controlled to supply liquid to the first cleaning pool 601 through the first liquid inlet 6011 to clean the outer wall of the pipette needle. When it is determined according to the first detection information that the outer wall of the pipette needle and the needle tip of the pipette needle do not have the attachment, the needle moving mechanism is controlled to drive the pipette needle to move to the first cleaning pool 601, and the first liquid supply component 602 is controlled to supply liquid to the first cleaning pool 601 through the first liquid inlet 6011 to clean the outer wall of the pipette needle.

[0105] Exemplarily, the needle detection device 90 is arranged to detect whether the outer wall of the sample needle 101 or the needle tip of the sample needle 101 has the attachment of the preset type.

[0106] When it is determined according to the first detection information that the outer wall of the sample needle 101 or the needle tip of the sample needle 101 has the attachment, it is indicated that the sample needle 101 needs to be pretreated, the first needle moving mechanism 102 is controlled to drive the sample needle 101 to move to the first processing position, and the needle processing device 50 is controlled to perform the first processing operation on the sample needle 101; after the first processing operation is completed, the first needle moving mechanism 102 is controlled to drive the sample needle 101 to move to the first cleaning pool 601, and the first liquid supply component 602 is controlled to supply liquid to the first cleaning pool 601 through the first liquid inlet 6011 to clean the outer wall of the sample needle 101.

[0107] When it is determined according to the first detection information that the outer wall of the sample needle 101 and the needle tip of the sample needle 101 do not have the attachment, it is indicated that the sample needle 101 does not need to be pretreated, the first needle moving mechanism 102 is controlled to drive the sample needle 101 to move to the first cleaning pool 601, and the first liquid supply component 602 is controlled to supply liquid to the first cleaning pool 601 through the first liquid inlet 6011 to clean the outer wall of the sample needle 101.

[0108] Optionally, the first detection information at least includes inner wall pressure information of the pipette needle, and the controller 70 is configured to: determine whether the inner wall pressure information is greater than a pressure threshold value, and when the inner wall pressure information is greater than the pressure threshold value, determine that the needle tip of the pipette needle has the attachment.

[0109] Exemplarily, the needle detection device 90 comprises a needle inner wall pressure detection component for detecting the inner wall pressure of the pipetting needle (e.g., the sample needle 101), which usually performs pipetting on at least one of the sample, the reagent or the reaction liquid at a preset pipetting pressure. The needle detection device 90 detects the pressure change of the pipetting needle during the pipetting or liquid discharging process, and when the detected pressure is greater than a threshold value, it indicates that the needle tip of the pipetting needle may be blocked, and then it is determined that the needle tip of the pipetting needle is attached with foreign matter.

[0110] Optionally, the needle detection device 90 comprises an image acquisition component for acquiring images of the pipetting needle during the pipetting or liquid discharging process, and the acquired images are analyzed to determine whether the outer wall of the sample needle 101 or the needle tip of the sample needle 101 is attached with foreign matter, and the corresponding detection information is output.

[0111] In some embodiments, before receiving the first detection information output by the needle detection device 90, the controller 70 is further configured to: control the needle moving mechanism to drive the pipetting needle to move below the liquid level of the target container located at the sample suction position, and control the power mechanism to drive the pipetting needle to perform a pipetting operation to suck the target liquid carried in the target container, the target liquid being the sample or a pretreatment liquid formed by the sample and a pretreatment reagent; after the pipetting operation is completed, control the needle moving mechanism to drive the pipetting needle to rise to a preset position; and during the process of the pipetting needle rising to the preset position, or after the pipetting needle rises to the preset position, control the needle detection device 90 to detect whether the outer wall of the pipetting needle and / or the needle tip of the pipetting needle is attached with foreign matter.

[0112] It can be understood that the pretreatment reagent can be a diluent, or other reagent for pretreating the sample, such as a fat-removing agent or a hemolytic agent.

[0113] Exemplarily, the first needle moving mechanism 102 is controlled to drive the sample needle 101 to move below the liquid level of the target container located at the sample suction position, and the first power mechanism 103 is controlled to drive the sample needle 101 to perform a pipetting operation to suck the target sample carried in the target container; after the pipetting operation is completed, the first needle moving mechanism 102 is controlled to drive the sample needle 101 to rise to a preset position; and during the process of the sample needle 101 rising to the preset position, or after the sample needle 101 rises to the preset position, the needle detection device 90 is controlled to detect whether the outer wall of the sample needle 101 and / or the needle tip of the sample needle 101 is attached with foreign matter, and output the corresponding detection information, so that the controller 70 determines whether the outer wall of the sample needle 101 and / or the needle tip of the sample needle 101 is attached with foreign matter according to the detection information output by the needle detection device 90, and selects a corresponding suitable cleaning mode to clean the sample needle 101.

[0114] In some embodiments, the needle treatment device 50 further includes a third liquid supply component 503a, which is connected to the needle inlet of the pipette needle and is used to supply liquid to the pipette needle through the needle inlet and discharge it through the needle outlet of the pipette needle to clean the inner wall of the pipette needle. When the controller 70 determines that there is deposited material on the tip of the pipette, it controls the needle processing device 50 to perform a first processing operation on the pipette, including: controlling the third liquid supply component 503a to supply liquid to the pipette through the needle inlet of the pipette, so that the deposited material on the tip of the pipette is discharged into a preset container under the action of the liquid discharged from the outlet of the pipette.

[0115] like Figure 5 As shown, when it is determined that there are deposits on the tip of the sample needle 101, the needle processing device 50 is controlled to perform a first processing operation on the sample needle 101, including: controlling the third liquid supply component 503a to supply liquid to the sample needle 101 through the needle inlet 1011 of the sample needle 101, so that the deposits on the tip of the sample needle 101 are discharged into a preset container under the action of liquid discharged from the needle outlet 1012 of the sample needle 101.

[0116] Optionally, the third liquid supply component 503a and the liquid supply component of the cleaning device 60 are powered by the same power assembly. For example, the third liquid supply component 503a and the first liquid supply component 602 are powered by the same power assembly.

[0117] In some embodiments, the sample analyzer 100 performs sample detection operations on the sample to be tested during the sample detection cycle; the controller 70 is also used for: When it is determined that there are deposits on the outer wall of the pipette and / or the tip of the pipette, the sample analyzer 100 is controlled to stop executing the sub-actions that have not been executed in the sample detection operation corresponding to the current sample detection cycle, and the needle moving mechanism is controlled to drive the pipette to the first processing position, and the needle processing device 50 is controlled to perform the first processing operation on the pipette. After the first processing operation is completed, the control needle moving mechanism drives the pipette needle to move to the first cleaning tank 601, and controls the first liquid supply component 602 to supply liquid to the first cleaning tank 601 through the first liquid inlet 6011 to clean the outer wall of the pipette needle. After the outer wall of the pipette is cleaned, the sample analyzer 100 is controlled to re-execute the sample detection operation on the target sample in other sample detection cycles after the current sample cycle. The target sample is the sample to be detected in the sample detection cycle that determines that there are deposits on the outer wall of the pipette and / or the tip of the pipette.

[0118] Exemplarily, the sample analyzer 100 performs a sample detection operation on a sample to be detected in a sample detection period, each sample detection period T detects and analyzes one sample to be detected, when it is determined that the outer wall of the sample needle 101 and / or the needle tip of the sample needle 101 has attachments, the control sample analyzer 100 stops performing the sub-operations that have not been performed in the sample detection operation corresponding to the current sample detection period, for example, if the current sample detection period is T0, if the mixing operation of the reaction solution, the incubation operation of the reaction solution, and the detection operation of the reaction solution in the current sample detection period have not been performed, stop the mixing operation, the incubation operation and the detection operation to be performed subsequently in the current sample detection period T0, and control the first needle moving mechanism 102 to drive the sample needle 101 to move to the first processing position, and control the needle processing device to perform the first processing operation on the sample needle 101, so as to process the attachments on the outer wall of the sample needle 101 and / or the needle tip of the sample needle 101 by performing the first processing operation in the remaining time of the current sample detection period T0.

[0119] After the first processing operation is completed, the control first needle moving mechanism 102 drives the sample needle 101 to move to the first cleaning pool 601, and controls the first liquid supply component 602 to supply liquid to the first cleaning pool 601 through the first liquid inlet 6011, so as to clean the outer wall of the sample needle 101.

[0120] After the outer wall of the sample needle 101 is cleaned, the control sample analyzer 100 re-performs the sample detection operation on the target sample in other sample detection periods after the current sample period, wherein the target sample is the sample to be detected in the sample detection period in which it is determined that the outer wall of the sample needle 101 and / or the needle tip of the sample needle 101 has attachments. For example, the current inspection item has N sample detection periods, and the periods after the current sample detection period T0 include T1, T2, T3, …, TN, one of T1 to TN is selected as the sample detection period of the target sample for re-measurement of the sample, or, the current inspection item has N sample detection periods, and the periods after the current sample detection period T0 include T1, T2, T3, …, TN, a new detection period is inserted between any two of T0 to TN, and the target sample is re-measured in the new detection period.

[0121] In some embodiments, the pipetting needle is provided with a needle liquid inlet and a needle liquid outlet, and the first liquid supply component is further configured to supply liquid to the pipetting needle through the needle liquid inlet; and the controller 70 is further configured to: after the first processing operation is completed, control the first liquid supply component 602 to supply liquid to the pipetting needle through the needle liquid inlet and discharge through the needle liquid outlet of the pipetting needle, so as to clean the inner wall of the pipetting needle. Alternatively, the pipetting needle is provided with a needle liquid inlet and a needle liquid outlet, and the cleaning device 60 further comprises a fourth liquid supply component 603 for supplying liquid to the pipetting needle through the needle liquid inlet, and the controller 70 is further configured to: after the first processing operation is completed, control the fourth liquid supply component 603 to supply liquid to the pipetting needle through the needle liquid inlet and discharge through the needle liquid outlet of the pipetting needle, so as to clean the inner wall of the pipetting needle.

[0122] As shown in Figure 4 As an example, the pipetting needle is taken as the sample needle 101, the sample needle 101 is provided with a needle liquid inlet 1011 and a needle liquid outlet 1012, and the inner wall of the sample needle 101 can be cleaned by supplying cleaning liquid to the needle liquid inlet 1011 of the sample needle 101 and discharging through the needle liquid outlet 1012 of the sample needle 101. The liquid supply component for supplying liquid to the needle liquid inlet 1011 can be the first liquid supply component 602 or the fourth liquid supply component 603. Alternatively, the first liquid supply component 602 and the fourth liquid supply component 603 are powered by the same power assembly.

[0123] In some embodiments, the sample analyzer 100 is provided with a first cleaning mode and a second cleaning mode, and the controller 70 is configured to: select one of the first cleaning mode and the second cleaning mode to clean the pipetting needle, wherein in the first cleaning mode, the controller 70 at least controls the needle moving mechanism to drive the pipetting needle to move to the first processing position, controls the needle processing device 50 to perform the first processing operation, after the first processing operation is completed, controls the needle moving mechanism to drive the pipetting needle to move to the first cleaning position, and controls the cleaning device 60 to perform the first cleaning operation on the pipetting needle located at the first cleaning position, the tip of the pipetting needle is provided with at least a needle liquid outlet for aspirating and discharging sample; The first processing operation is at least used for processing the attachments on the outer wall of the pipetting needle or the attachments on the tip of the pipetting needle; in the second cleaning mode, the controller 70 at least controls the cleaning device 60 to perform the first cleaning operation, and the first cleaning operation is used for cleaning the outer wall of the pipetting needle.

[0124] Alternatively, in the first cleaning mode, the controller is further configured to: after the first processing operation is completed, control the needle moving mechanism to drive the pipetting needle to move to the first cleaning position, and control the cleaning device 60 to perform the first cleaning operation on the pipetting needle located at the first cleaning position.

[0125] As an example, the pipetting needle is taken as the sample needle 101, the sample needle 101 is provided with a needle liquid inlet 1011 and a needle liquid outlet 1012, and the inner wall of the sample needle 101 can be cleaned by supplying cleaning liquid to the needle liquid inlet 1011 of the sample needle 101 and discharging through the needle liquid outlet 1012 of the sample needle 101. The liquid supply component for supplying liquid to the needle liquid inlet 1011 can be the first liquid supply component 602 or the fourth liquid supply component 603. Alternatively, the first liquid supply component 602 and the fourth liquid supply component 603 are powered by the same power assembly.

[0126] The controller 70 selects the first cleaning mode to clean the sample needle 101, specifically, controls the first needle moving mechanism 102 to drive the sample needle 101 to move to the first processing position, and controls the needle processing device 50 to perform a first processing operation on the sample needle located at the first processing position, so as to process the preset type of attachments attached to the outer wall of the sample needle 101 and / or the preset type of attachments attached to the needle tip of the sample needle 101 through the first processing operation.

[0127] Optionally, after the first processing operation is completed, the controller 70 controls the first needle moving mechanism 102 to drive the sample needle 101 to move from the first processing position to the first cleaning pool 601, and controls the first liquid supply component 602 to supply liquid to the first cleaning pool 601 through the first liquid inlet 6011, so as to clean the outer wall of the sample needle 101 located in the first cleaning pool 601.

[0128] In the case that the preset type of attachments such as fibrin, separation gel or mixed beads does not exist on the needle tip of the sample needle 101, or the preset type of attachments does not exist on the outer wall of the sample needle, or the user wants to process the sample needle 101 through the cleaning device 60.

[0129] The controller 70 selects the second cleaning mode to clean the sample needle 101, specifically, controls the first needle moving mechanism 102 to drive the sample needle 101 to move to the first cleaning position, and controls the cleaning device 60 to clean the sample needle 101 located at the first cleaning position, for example, the first cleaning position is located in the first cleaning pool 601, and the first liquid supply component 602 is controlled to supply liquid to the first cleaning pool 601 through the first liquid inlet 6011, so as to clean the outer wall of the sample needle 101 located in the first cleaning pool 601.

[0130] As can be seen from the above embodiments, the sample analyzer 100 is provided with two different cleaning modes, and the cleaning operations performed on the pipette needle are different in different cleaning modes, thereby providing multiple adaptive cleaning modes for different pipette needle use scenarios, which helps to improve the cleaning effect of the pipette needle in different use scenarios. For example, in the case that the attachments such as mixed beads, fibrin or separation gel are attached to at least one of the outer wall and the needle tip of the pipette needle, the first cleaning mode is selected to clean the pipette needle, so as to at least process the attachments on the outer wall of the pipette needle or the needle tip of the pipette needle through the needle processing device 50, thereby avoiding the poor cleaning effect or even the cleaning blockage caused by the conventional cleaning mode for cleaning the attachments on the outer wall and the needle tip of the pipette needle, and effectively improving the cleaning effect of the pipette needle.

[0131] In some embodiments, the sample analyzer 100 further comprises a needle detection device 90 for detecting whether the attachments exist on the outer wall of the pipette needle and / or the needle tip of the pipette needle. The controller 70 is further configured to receive first detection information output by the needle detection device 90, select the first cleaning mode to clean the pipetting needle when it is determined according to the first detection information that there is attachment on the outer wall of the pipetting needle or the needle tip of the pipetting needle, and select the second cleaning mode to clean the pipetting needle when it is determined according to the first detection information that there is no attachment on the outer wall of the pipetting needle and the needle tip of the pipetting needle.

[0132] It should be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the present application. As used in this specification and the appended claims, the singular forms "a", "an" and "the" are intended to include plural forms as well, unless the context clearly indicates otherwise.

[0133] It should also be understood that the term "and / or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items, and that the term "at least one of" followed by a list of two or more items means any single one of the items in the list, and that the term "one or more of" followed by a list of two or more items means any single one or plurality of the items in the list. It should be further understood that the terms "comprises" and / or "comprising", or "includes" and / or "including" when used in this specification and in the following claims, are intended to specify the presence of stated features, integers, steps, operations, processes, actions, elements, or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, processes, actions, elements, components, or groups thereof.

[0134] The above-mentioned sequence numbers of the embodiments of the present application are only for description, and do not represent advantages or disadvantages of the embodiments. The above describes only specific embodiments of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art can easily think of various equivalent modifications or replacements within the technical scope disclosed by the present application, and these modifications or replacements should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A sample analyzer characterized by, The sample analyzer comprises: a dispensing device configured to perform a dispensing operation of a sample and / or a reagent, wherein the dispensing device comprises a pipette needle, a pipette needle moving mechanism, and a power mechanism, the pipette needle is configured to transfer at least the sample, the pipette needle moving mechanism is configured to drive the pipette needle to move, and the power mechanism is configured to provide power for the pipette needle to suck and discharge the sample; a needle processing device configured to process at least an adherent on an outer wall of the pipette needle or an adherent on a needle tip of the pipette needle, the needle tip of the pipette needle is provided with at least a needle discharge port configured to suck and discharge the sample; a cleaning device comprising a first cleaning pool and a first liquid supply component, the first cleaning pool is provided with a first liquid inlet, and the first liquid supply component is connected to the first liquid inlet and configured to supply liquid to the first cleaning pool through the first liquid inlet; a controller connected in communication with the pipette needle moving mechanism, the needle processing device, and the first liquid supply component, and configured to: control the pipette needle moving mechanism to drive the pipette needle to move to a first processing position, and control the needle processing device to perform a first processing operation on the pipette needle, the first processing operation is configured to process at least the adherent on the outer wall of the pipette needle or the adherent on the needle tip of the pipette needle; after the first processing operation is completed, control the pipette needle moving mechanism to drive the pipette needle to move from the first processing position to the first cleaning pool, and control the first liquid supply component to supply liquid to the first cleaning pool through the first liquid inlet to clean the outer wall of the pipette needle.

2. The sample analyzer of claim 1, wherein, The sample analyzer further comprises a needle detection device connected in communication with the controller and configured to detect whether there is an adherent on the outer wall of the pipette needle and / or the needle tip of the pipette needle; before controlling the pipette needle moving mechanism to drive the pipette needle to move to the first processing position, the controller is further configured to receive first detection information output by the needle detection device; when it is determined according to the first detection information that there is an adherent on the outer wall of the pipette needle or the needle tip of the pipette needle, control the pipette needle moving mechanism to drive the pipette needle to move to the first processing position, and control the needle processing device to perform the first processing operation on the pipette needle; after the first processing operation is completed, control the pipette needle moving mechanism to drive the pipette needle to move to the first cleaning pool, and control the first liquid supply component to supply liquid to the first cleaning pool through the first liquid inlet to clean the outer wall of the pipette needle; when it is determined according to the first detection information that there is no adherent on the outer wall of the pipette needle and the needle tip of the pipette needle, control the pipette needle moving mechanism to drive the pipette needle to move to the first cleaning pool, and control the first liquid supply component to supply liquid to the first cleaning pool through the first liquid inlet to clean the outer wall of the pipette needle.

3. The sample analyzer of claim 2, wherein, The first detection information at least comprises inner wall pressure information of the pipette needle, and the controller is further configured to: determine whether the inner wall pressure information is greater than a pressure threshold value, and when the inner wall pressure information is greater than the pressure threshold value, determine that there is an adherent on the needle tip of the pipette needle.

4. The sample analyzer of claim 2, wherein, The sample analyzer performs a sample detection operation on a sample to be detected in a sample detection period; the controller is further configured to: When it is determined that the outer wall of the pipette needle and / or the tip of the pipette needle has the attachment, the controller controls the sample analyzer to stop performing a sub-action not performed in the sample detection operation corresponding to the current sample detection period, controls the needle moving mechanism to drive the pipette needle to move to the first processing position, and controls the needle processing device to perform the first processing operation on the pipette needle. After the first processing operation is performed, the controller controls the needle moving mechanism to drive the pipette needle to move to the first cleaning pool, and controls the first liquid supply component to supply liquid to the first cleaning pool through the first liquid inlet to clean the outer wall of the pipette needle. After the outer wall of the pipette needle is cleaned, the controller controls the sample analyzer to re-perform the sample detection operation on a target sample in a sample detection period after the current sample period, wherein the target sample is a sample to be detected in the sample detection period in which it is determined that the outer wall of the pipette needle and / or the tip of the pipette needle has the attachment.

5. The sample analyzer of claim 2, wherein, Before receiving the first detection information output by the needle detection device, the controller is further configured to: control the needle moving mechanism to drive the pipette needle to move below the liquid surface of a target container located at the sample suction position, and control the power mechanism to drive the pipette needle to perform a liquid suction operation to suck the target liquid carried in the target container, the target liquid being a sample or a pretreatment liquid formed by a sample and a pretreatment reagent; After the liquid suction operation is performed, the controller controls the needle moving mechanism to drive the pipette needle to rise to a preset position, and controls the needle detection device to detect whether the outer wall of the pipette needle and / or the tip of the pipette needle has the attachment during the process of the pipette needle rising to the preset position or after the pipette needle rises to the preset position.

6. The sample analyzer of claim 1, wherein, The first cleaning pool further forms a first cleaning cavity for the pipette needle to be inserted and a first liquid outlet communicating with the first cleaning cavity, and the liquid in the first cleaning cavity can be discharged through the first liquid outlet; the needle processing device comprises a second cleaning pool and a second liquid supply component, the second cleaning pool forms a second cleaning cavity for the pipette needle to be inserted, a second liquid inlet communicating with the second cleaning cavity, and a second liquid outlet communicating with the second cleaning cavity, the liquid in the second cleaning cavity can be discharged through the second liquid outlet, and the inner diameter of the second cleaning cavity is greater than that of the first cleaning cavity, and the second liquid supply component is configured to supply liquid to the second cleaning cavity through the second liquid inlet; during the execution of the first processing operation by the needle processing device, the controller is configured to control the second liquid supply component to supply liquid to the second liquid inlet to clean the attachment on the outer wall of the pipette needle and / or the tip of the pipette needle in the second cleaning cavity. Alternatively, the first cleaning pool is further formed with a first cleaning cavity for insertion of the pipetting needle and a first liquid discharge port communicating with the first cleaning cavity, liquid in the first cleaning cavity being discharged through the first liquid discharge port; the needle processing device further comprises a second cleaning pool, the second cleaning pool being formed with a second cleaning cavity for insertion of the pipetting needle, a second liquid inlet port communicating with the second cleaning cavity, and a second liquid discharge port communicating with the second cleaning cavity, liquid in the second cleaning cavity being discharged through the second liquid discharge port, and an inner diameter of the second cleaning cavity being greater than an inner diameter of the first cleaning cavity, the first liquid supply component further being configured to supply liquid to the second cleaning cavity through the second liquid inlet port; The controller controls the needle processing device to perform the first processing operation, including controlling the first liquid supply component to supply liquid to the second liquid inlet port to clean the adhering matter on the outer wall of the pipetting needle and / or the adhering matter on the needle tip of the pipetting needle in the second cleaning cavity.

7. The sample analyzer of claim 6, wherein, The needle processing device further comprises a filter, the filter being connected with the second cleaning pool and being arranged at the second liquid discharge port.

8. The sample analyzer of claim 7, wherein, The filter is detachably connected with the second cleaning pool, and the filter is formed with a filter cavity, an inner diameter of the filter cavity being greater than or equal to an inner diameter of the second cleaning cavity.

9. The sample analyzer of claim 6, wherein, The second liquid inlet port arranged at the second cleaning cavity extends in a first direction, the second cleaning cavity extends in a second direction, and the second direction and the first direction are arranged at an included angle.

10. The sample analyzer of claim 1, wherein, At least two first liquid inlet ports are oppositely arranged at the side wall of the first cleaning pool.

11. The sample analyzer of claim 1, wherein, The needle processing device further comprises an ultrasonic cleaning pool and an ultrasonic generator, the ultrasonic cleaning pool being formed with an ultrasonic cleaning cavity for insertion of the pipetting needle, a third liquid inlet port communicating with the ultrasonic cleaning cavity, and a third liquid discharge port communicating with the ultrasonic cleaning cavity, cleaning liquid being able to enter the ultrasonic cleaning cavity through the third liquid inlet port, and liquid in the ultrasonic cleaning cavity being able to be discharged through the third liquid discharge port; during the first processing operation performed by the needle processing device, the controller is configured to control the ultrasonic generator to output ultrasonic vibration, so that the ultrasonic vibration is transmitted to the outer wall and the needle tip of the pipetting needle through the cleaning liquid in the ultrasonic cleaning pool.

12. The sample analyzer of claim 1, wherein, The needle processing device comprises a wiping component, the wiping component being provided with a wiping member for wiping the pipetting needle, and the recovery component is configured to recover at least the adhering matter on the outer wall of the pipetting needle or the adhering matter on the needle tip of the pipetting needle. The controller controls the needle processing device to perform a first processing operation on the pipetting needle, including: controlling the needle moving mechanism to drive the pipetting needle to move towards the wiping component so that the pipetting needle and the wiping member of the wiping component are in contact; and controlling the needle moving mechanism and / or the wiping component to perform a first processing action to wipe the adhering matter on the outer wall of the pipetting needle and / or the needle tip of the pipetting needle by the wiping member; the first processing action includes one of: controlling the needle moving mechanism to drive the pipetting needle to move relative to the wiping component in the extension direction of the pipetting needle; controlling the wiping component to move relative to the pipetting needle in the extension direction of the pipetting needle; controlling the needle moving mechanism to drive the pipetting needle to move in the extension direction of the pipetting needle, and controlling the wiping component to move in the extension direction of the pipetting needle so that the pipetting needle and the wiping member arranged on the wiping component move relatively at least in the extension direction of the pipetting needle. Alternatively, the controller controls the needle processing device to perform a first processing operation on the pipetting needle, including: controlling the wiping component to move towards the pipetting needle located at the first processing position so that the pipetting needle and the wiping member of the wiping component are in contact; and controlling the needle moving mechanism and / or the wiping component to perform a first processing action to wipe the adhering matter on the outer wall of the pipetting needle and / or the needle tip of the pipetting needle by the wiping member; the first processing action includes one of: controlling the needle moving mechanism to drive the pipetting needle to move relative to the wiping component in the extension direction of the pipetting needle; controlling the wiping component to move relative to the pipetting needle in the extension direction of the pipetting needle; controlling the needle moving mechanism to drive the pipetting needle to move in the extension direction of the pipetting needle, and controlling the wiping component to move in the extension direction of the pipetting needle so that the pipetting needle and the wiping member arranged on the wiping component move relatively at least in the extension direction of the pipetting needle.

13. The sample analyzer of claim 2, wherein, The pipetting needle is also provided with a needle liquid inlet, and the needle processing device further includes a third liquid supply component which communicates with the needle liquid inlet and is used to supply liquid to the pipetting needle through the needle liquid inlet. When the controller determines that the needle tip of the pipetting needle has adhering matter, the controller controls the needle processing device to perform a first processing operation on the pipetting needle, including: controlling the third liquid supply component to supply liquid to the pipetting needle through the needle liquid inlet and discharge the liquid through the needle liquid outlet, so that the adhering matter on the needle tip of the pipetting needle is discharged to a preset container under the action of the liquid discharged through the needle liquid outlet.

14. The sample analyzer of claim 13, wherein, The third liquid supply component and the first liquid supply component are powered by the same power assembly.

15. The sample analyzer of claim 1, wherein, The pipetting needle is also provided with a needle liquid inlet, and the first liquid supply component is also used to supply liquid to the pipetting needle through the needle liquid inlet; and the controller is further configured to: after the first processing operation is completed, control the first liquid supply component to supply liquid to the pipetting needle through the needle liquid inlet and discharge the liquid through the needle liquid outlet, so as to clean the inner wall of the pipetting needle; Alternatively, the pipetting needle is provided with a needle liquid inlet, and the cleaning device further comprises a fourth liquid supply component configured to supply liquid to the pipetting needle through the needle liquid inlet and discharge the liquid through the needle liquid outlet, and the controller is further configured to: after the first treatment operation is completed, control the fourth liquid supply component to supply liquid to the pipetting needle through the needle liquid inlet and discharge the liquid through the needle liquid outlet, so as to clean the inner wall of the pipetting needle.

16. A sample analyzer characterized by, The sample analyzer comprises: a dispensing device configured to perform a dispensing operation of a sample and / or a reagent, wherein the dispensing device comprises a pipetting needle, a needle moving mechanism, and a power mechanism, the pipetting needle is configured to transfer the sample and / or the reagent, the needle moving mechanism is configured to drive the pipetting needle to move, and the power mechanism is configured to provide power for the pipetting needle to suck and discharge the sample and / or the reagent; a needle treatment device configured to at least treat the adhering matter on the outer wall of the pipetting needle or the adhering matter on the needle tip of the pipetting needle; a cleaning device configured to at least provide cleaning liquid to clean the outer wall of the pipetting needle; a controller, the sample analyzer is provided with a first cleaning mode and a second cleaning mode, and the controller is configured to: select one of the first cleaning mode and the second cleaning mode to clean the pipetting needle, wherein in the first cleaning mode, the controller is configured to at least control the needle moving mechanism to drive the pipetting needle to move to a first treatment position, control the needle treatment device to perform a first treatment operation, after the first treatment operation is completed, control the needle moving mechanism to drive the pipetting needle to move to a first cleaning position, and control the cleaning device to perform the first cleaning operation on the pipetting needle located at the first cleaning position, the first treatment operation is at least configured to treat the adhering matter on the outer wall of the pipetting needle or the adhering matter on the needle tip of the pipetting needle, and the needle tip of the pipetting needle is provided with a needle liquid outlet configured to at least suck and discharge the sample; in the second cleaning mode, the controller is configured to at least control the cleaning device to perform the first cleaning operation, and the first cleaning operation is configured to clean the outer wall of the pipetting needle.

17. The sample analyzer of claim 16, wherein, In the first cleaning mode, the controller is further configured to: after the first treatment operation is completed, control the needle moving mechanism to drive the pipetting needle to move to a first cleaning position, and control the cleaning device to perform the first cleaning operation on the pipetting needle located at the first cleaning position.

18. The sample analyzer of claim 16, wherein, The sample analyzer further comprises a needle detection device configured to detect whether there is adhering matter on the outer wall of the pipetting needle and / or the needle tip of the pipetting needle; the controller is further configured to: receive first detection information output by the needle detection device; when it is determined according to the first detection information that there is adhering matter on the outer wall of the pipetting needle or the needle tip of the pipetting needle, select the first cleaning mode to clean the pipetting needle; when it is determined according to the first detection information that there is no adhering matter on the outer wall of the pipetting needle and the needle tip of the pipetting needle, select the second cleaning mode to clean the pipetting needle.

19. The sample analyzer of claim 18, wherein, The sample analyzer performs a sample detection operation on a sample to be detected in a sample detection period, and the controller is further configured to: When it is determined that the outer wall of the pipette needle and / or the tip of the pipette needle has the attachment, the controller controls the sample analyzer to stop performing a sub-action that is not performed in the sample detection operation corresponding to the current sample detection period, and controls the sample analyzer to select the first cleaning mode to clean the outer wall of the pipette needle. After the cleaning of the outer wall of the pipette needle is completed, the controller controls the sample analyzer to re-perform the sample detection operation on a target sample in a sample detection period subsequent to the current sample period, wherein the target sample is a sample to be detected in the sample detection period in which it is determined that the outer wall of the pipette needle and / or the tip of the pipette needle has the attachment.

20. The sample analyzer of claim 16, wherein, Before receiving the first detection information output by the needle detection device, the controller is further configured to: control the needle moving mechanism to drive the pipette needle to move below the liquid level of a target container located at the sample suction position, and control the power mechanism to drive the pipette needle to perform a liquid suction operation to suck a target liquid carried in the target container, the target liquid being a sample or a pretreatment liquid formed by a sample and a pretreatment reagent; after the liquid suction operation is completed, control the needle moving mechanism to drive the pipette needle to rise to a preset position; and during the process that the pipette needle rises to the preset position, or after the pipette needle rises to the preset position, control the needle detection device to detect whether the outer wall of the pipette needle and / or the tip of the pipette needle has the attachment.

21. The sample analyzer of claim 16, wherein, The cleaning device comprises a first cleaning pool and a first liquid supply component, the first cleaning pool is provided with a first liquid inlet, and the first liquid supply component is connected to the first liquid inlet and is configured to supply liquid to the first cleaning pool through the first liquid inlet; During the process that the controller controls the cleaning device to perform the first cleaning operation, the controller is configured to: control the needle moving mechanism to drive the pipette needle to move to the first cleaning pool, and control the first liquid supply component to supply liquid to the first cleaning pool through the first liquid inlet to clean the outer wall of the pipette needle; The first cleaning pool further forms a first cleaning cavity for the pipette needle to be inserted and a first liquid outlet connected to the first cleaning cavity, and the liquid in the first cleaning cavity can be discharged through the first liquid outlet; the needle processing device comprises a second cleaning pool and a second liquid supply component, the second cleaning pool forms a second cleaning cavity for the pipette needle to be inserted, a second liquid inlet connected to the second cleaning cavity, and a second liquid outlet connected to the second cleaning cavity, the liquid in the second cleaning cavity can be discharged through the second liquid outlet, and the inner diameter of the second cleaning cavity is greater than the inner diameter of the first cleaning cavity, and the second liquid supply component is configured to supply liquid to the second cleaning cavity through the second liquid inlet; during the process that the needle processing device performs the first processing operation, the controller is configured to: control the second liquid supply component to supply liquid to the second liquid inlet to clean the attachment on the outer wall of the pipette needle and / or the tip of the pipette needle located in the second cleaning cavity; Alternatively, the first cleaning pool is further formed with a first cleaning cavity for the pipette needle to be inserted and a first liquid discharge port communicating with the first cleaning cavity, liquid in the first cleaning cavity being able to be discharged through the first liquid discharge port; the needle processing device comprises a second cleaning pool, the second cleaning pool being formed with a second cleaning cavity for the pipette needle to be inserted, a second liquid inlet port communicating with the second cleaning cavity, and a second liquid discharge port communicating with the second cleaning cavity, liquid in the second cleaning cavity being able to be discharged through the second liquid discharge port, and an inner diameter of the second cleaning cavity being greater than an inner diameter of the first cleaning cavity, the first liquid supply component being further used for supplying liquid to the second cleaning cavity through the second liquid inlet port; during execution of the first processing operation by the needle processing device, the controller is used for controlling the first liquid supply component to supply liquid to the second liquid inlet port, so as to clean the adhering matter on the outer wall of the pipette needle and / or the adhering matter on the needle tip of the pipette needle located in the second cleaning cavity.

22. The sample analyzer of claim 16, wherein, The needle processing device comprises a wiping component, the wiping component being provided with a wiping member for wiping the pipette needle, and the recovery component is used for recovering at least the adhering matter adhered to the pipette needle. During execution of the first processing operation by the needle processing device, the controller is used for: controlling the needle moving mechanism to drive the pipette needle to move towards the wiping component, so that the pipette needle and the wiping member of the wiping component are in contact; and controlling the needle moving mechanism and / or the wiping component to perform a first processing action, so as to wipe the adhering matter on the outer wall of the pipette needle and / or the adhering matter on the needle tip of the pipette needle by the wiping member; the first processing action comprises one of the following: controlling the needle moving mechanism to drive the pipette needle to move relative to the wiping component in an extension direction of the pipette needle; controlling the wiping component to move relative to the pipette needle in the extension direction of the pipette needle; controlling the needle moving mechanism to drive the pipette needle to move in the extension direction of the pipette needle, and controlling the wiping component to move in the extension direction of the pipette needle, so that the pipette needle and the wiping member provided on the wiping component move relatively at least in the extension direction of the pipette needle. Alternatively, the controller controls the wiping component to move towards the pipette needle located at the first processing position to make the pipette needle contact with a wiping member of the wiping component during the control of the needle processing device to perform the first processing operation on the pipette needle; and controls the needle moving mechanism and / or the wiping component to perform a first processing action to wipe the adhering matter on the outer wall of the pipette needle and / or the adhering matter on the needle tip of the pipette needle by the wiping member; the first processing action comprises one of the following: controlling the needle moving mechanism to drive the pipette needle to move relative to the wiping component in the extension direction of the pipette needle; controlling the wiping component to move relative to the pipette needle in the extension direction of the pipette needle; controlling the needle moving mechanism to drive the pipette needle to move in the extension direction of the pipette needle, and controlling the wiping component to move in the extension direction of the pipette needle to make the pipette needle and the wiping member arranged on the wiping component relatively move at least in the extension direction of the pipette needle.

23. The sample analyzer of claim 16, wherein, The needle processing device comprises an ultrasonic cleaning tank and an ultrasonic generator, the ultrasonic cleaning tank is formed with an ultrasonic cleaning cavity for inserting the pipette needle, a third liquid inlet communicating with the ultrasonic cleaning cavity, and a third liquid outlet communicating with the ultrasonic cleaning cavity; cleaning liquid can enter the ultrasonic cleaning cavity through the third liquid inlet, and liquid in the ultrasonic cleaning cavity can be discharged through the third liquid outlet; during the execution of the first processing operation by the needle processing device, the controller is configured to control the ultrasonic generator to output ultrasonic vibration to perform ultrasonic cleaning on the adhering matter on the outer wall of the pipette needle and / or the adhering matter on the needle tip of the pipette needle by the cleaning liquid in the ultrasonic cleaning tank.

24. The sample analyzer of claim 18, wherein, The pipette needle is provided with a needle liquid outlet, and the cleaning liquid emitted through the needle liquid outlet is used to clean the inner wall of the pipette needle; the needle processing device further comprises a third liquid supply component, the third liquid supply component communicates with the needle liquid outlet and is configured to supply liquid to the pipette needle through the needle liquid outlet; The controller controls the needle processing device to perform the first processing operation on the pipette needle when it is determined that the needle tip of the pipette needle has adhering matter, including: controlling the third liquid supply component to supply liquid to the pipette needle through the needle liquid outlet to discharge the adhering matter on the needle tip of the pipette needle to a preset container; wherein the third liquid supply component and the liquid supply component of the cleaning device are powered by the same power assembly.

25. A cleaning assembly for use in a sample analyzer provided with a pipetting needle for performing sample and / or reagent transfer, characterized in that, The cleaning assembly comprises: a needle processing device configured to process the adhering matter on the outer wall of the pipette needle or the adhering matter on the needle tip of the pipette needle; a cleaning device configured to at least supply cleaning liquid to clean the outer wall of the pipette needle.

26. The cleaning assembly of claim 25, wherein, The cleaning device comprises a first cleaning tank and a first liquid supply component, wherein the first cleaning tank is formed with a first cleaning cavity for inserting the pipette needle, a first liquid inlet, and a first liquid outlet communicating with the first cleaning cavity; the first liquid supply component communicates with the first liquid inlet and is configured to supply liquid to the first cleaning tank through the first liquid inlet, and liquid in the first cleaning cavity can be discharged through the first liquid outlet; The needle processing device comprises a second cleaning tank and a second liquid supply component, wherein the second cleaning tank is formed with a second cleaning cavity for inserting the pipetting needle, a second liquid inlet communicating with the second cleaning cavity, and a second liquid outlet communicating with the second cleaning cavity, liquid in the second cleaning cavity can be discharged through the second liquid outlet, and the inner diameter of the second cleaning cavity is larger than that of the first cleaning cavity.

27. The cleaning assembly of claim 26, wherein, The first liquid supply component and the second liquid supply component share the same power assembly.

28. The cleaning assembly of claim 26, wherein, The needle processing device further comprises a filter, which is detachably connected with the second cleaning tank and arranged at the second liquid outlet.

29. The cleaning assembly of claim 26, wherein, The needle processing device comprises a wiping component and a recovery component, the wiping component is provided with a wiping member for wiping the pipetting needle, and the recovery component is used for recovering at least the attachments falling off during wiping the pipetting needle.

30. The sample analyzer of claim 26, wherein, The needle processing device further comprises an ultrasonic cleaning tank and an ultrasonic generator, the ultrasonic cleaning tank is formed with an ultrasonic cleaning cavity for inserting the pipetting needle, a third liquid inlet communicating with the ultrasonic cleaning cavity, and a third liquid outlet communicating with the ultrasonic cleaning cavity, cleaning liquid can enter the ultrasonic cleaning cavity through the third liquid inlet, and liquid in the ultrasonic cleaning cavity can be discharged through the third liquid outlet.

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