Method and device for preparing 212Pb based on 226Ra

Abstract

The embodiment of the invention discloses a method and a device for preparing 212Pb based on 226Ra, and the method comprises the following steps: carrying out reactor irradiation treatment on a target material containing 226Ra to obtain an irradiated target material; and dissolving the irradiation target material to obtain a target material dissolving solution. The target material dissolving solution is placed in a first separation column to be subjected to first acid leaching treatment, a Th-containing adsorption column is obtained, and the first separation column is used for adsorbing Th. And carrying out second acid leaching treatment on the Th-containing adsorption column to obtain a Th-containing eluent. And carrying out standing treatment on the Th-containing eluent to obtain a standing solution containing 228Th. And the standing liquid containing 228Th is placed in a second separation column to be subjected to third acid leaching treatment, eluant containing 212Pb is obtained, and the second separation column is used for separating lead.

Description

Technical Field

[0001] This application relates to the field of isotope technology, and more particularly to a method based on... 226 Ra preparation 212 Methods and apparatus for Pb. Background Technology

[0002] Targeted alpha therapy (TAT) uses alpha radionuclides instead of traditional beta and positron-emitting radionuclides for cancer treatment, demonstrating unique advantages in the treatment of small tumors, scattered tumors, and tumors with micrometastases. 212 Pb is a typical medical isotope suitable for TAT technology. Its daughter particles can emit high-energy alpha particles and have high cytotoxicity, showing great promise for cancer treatment.

[0003] at present, 212 Common extraction methods for Pb include: (1) from natural nuclides 232 Extracted from the daughter of Th; (2) through 232 Extraction of decay products of U. However, the above extraction methods have complex processes, are difficult to engineer, and are hard to produce stably in the long term. 212 Pb. Summary of the Invention

[0004] Firstly, this application provides a method based on... 226 Ra preparation 212 Pb's methods include:

[0005] S102, for containing 226 Ra target material is subjected to reactor irradiation treatment to obtain irradiated target material;

[0006] S104, dissolves the irradiated target material to obtain a target material solution;

[0007] S106, The target material solution is placed in the first separation column for the first acid elution treatment to obtain a Th-containing adsorption column. The first separation column is used to adsorb Th.

[0008] S108, the Th-containing adsorption column is subjected to a second acid elution to obtain a Th-containing eluent;

[0009] S110, the th-containing eluent was allowed to stand for a period of time to obtain... 228 Th standing liquid;

[0010] S112, containing 228 The Th settling solution was placed in the second separation column for a third acid elution treatment to obtain a solution containing... 212 The Pb eluent was used to separate lead in the second separation column.

[0011] In a possible implementation, S110, the Th-containing eluate is subjected to a standing treatment, specifically including: standing the Th-containing eluate for 150-300 days.

[0012] In a possible implementation, the method further includes: S114, subjecting the second separation column after the third acid elution treatment to a fourth acid elution treatment to obtain a Th-containing recovery solution.

[0013] In a possible implementation, the acid concentration in the fourth acid elution treatment is different from the acid concentration in the third acid elution treatment.

[0014] In a possible implementation, the Th-containing eluate 226 The Ra target material includes one of radium nitrate, radium chloride, radium carbonate, radium sulfate, and radium bromide.

[0015] In a possible implementation, one of nitric acid, hydrochloric acid, and hydrofluoric acid is used in the dissolution treatment, and the acid concentration in the dissolution treatment is 1-4 mol / L.

[0016] In a possible implementation, inorganic acid is used in the first acid elution treatment, the second acid elution treatment, the third acid elution treatment, and the fourth acid elution treatment, and the inorganic acid is nitric acid or hydrochloric acid.

[0017] In a possible implementation, when the adsorption material of the Th-containing adsorption column is ion exchange resin, the acid concentration in the second acid elution treatment is 6-11.0 mol / L.

[0018] In a possible implementation, when the adsorption material of the Th-containing adsorption column is ion exchange resin, the acid concentration in the second acid elution treatment is 6-11.0 mol / L.

[0019] In a possible implementation, the acid concentration in the third acid elution treatment is 0.01-2 mol / L.

[0020] In a possible implementation, the acid concentration in the fourth acid elution treatment is 0.5-1.5 mol / L.

[0021] In a possible implementation, the elution flow rate in the first acid elution treatment, the second acid elution treatment, the third acid elution treatment, and the fourth acid elution treatment is 0.01-5 mL / min.

[0022] In a second aspect, the present application provides a kind of based on 226 Ra preparation 212A device for implementing any of the above methods, the device comprising a shielding box, a target material dissolving assembly, a first separation column, a second separation column and a solution bottle, the target material dissolving assembly is arranged in the shielding box and used for accommodating and dissolving irradiation target material. The inlet end of the first separation column is in communication with the target material dissolving assembly, and the first separation column is used for adsorbing Th. The second separation column is in communication with the outlet end of the first separation column, and the second separation column is used for separating lead. The solution bottle is in communication with the outlet end of the second separation column and used for collecting the lead eluent. 212 Pb eluent.

[0023] Compared with the prior art, the application has the beneficial effects that:

[0024] In the application, the Ra target material is subjected to reactor irradiation treatment to obtain irradiation target material containing a plurality of nuclides, and then the irradiation target material is subjected to separation and extraction to obtain 226 Pb. 212 The preparation process is simple, the separation efficiency is high, the yield is high, and the amount of waste is small, which can effectively reduce the irradiation dose of the operator, the preparation method is suitable for medical scenarios, can realize 212 Large-scale preparation of Pb, and alleviate the situation of insufficient supply of Pb. 212 Pb for tumor treatment research. 212 Pb medical isotopes.

[0025] Additional aspects and advantages of the application will be in part apparent and in part pointed out hereinafter in the description. BRIEF DESCRIPTION OF DRAWINGS

[0026] In order to more clearly illustrate the technical solutions in the embodiments of the application, the drawings needed in the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the application, and other drawings can be obtained by those skilled in the art without creative labor.

[0027] Figure 1 A flowchart of the method for preparing 226 Ra to Pb provided by an embodiment of the application; 212 Pb.

[0028] Figure 2 A flowchart of the method for preparing 226 Ra to Pb provided by an embodiment of the application; 212 Pb.

[0029] Figure 3 A device for preparing 226 Ra to Pb provided by an embodiment of the application; 212 Pb.

[0030] Reference Signs List:

[0031] 1 first solution bottle, 2 second solution bottle, 3 first multi-way valve, 4 first power pump, 5 third solution bottle, 6 flask, 7 second power pump, 8 second multi-way valve, 9 first separation column, 10 third multi-way valve, 11 fourth solution bottle, 12 third power pump, 13 fifth solution bottle, 14 fourth multi-way valve, 15 second separation column, 16 fifth multi-way valve, 17 sixth solution bottle, 18 seventh solution bottle, 19 fourth power pump, 20 eighth solution bottle, 21 hot plate, 22 shield box. DETAILED DESCRIPTION

[0032] The technical solutions in the embodiments of the present application will be described clearly and completely below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work are within the scope of protection of the present application.

[0033] In the present application, the terms "upper", "lower", "left", "right", "front", "back", "top", "bottom", "inner", "outer", "vertical", "horizontal", "lateral", "longitudinal", and the like indicate the orientation or positional relationship shown in the drawings. These terms are mainly used to better describe the present application and its embodiments, and are not intended to limit the indicated devices, elements or components to have a specific orientation, or to be constructed and operated in a specific orientation.

[0034] In addition, in addition to being used to indicate the orientation or positional relationship, the above-mentioned partial terms can also be used to indicate other meanings, for example, the term "upper" can also be used to indicate a certain dependent relationship or connection relationship in some cases. Those of ordinary skill in the art can understand the specific meaning of these terms in the present application according to the specific circumstances.

[0035] In addition, the terms "mount", "set", "provided with", "connect", "connected" should be understood broadly. For example, it can be fixedly connected, detachably connected, or integrally constructed; it can be mechanically connected, or electrically connected; it can be directly connected, or indirectly connected through an intermediate medium, or internal communication between two devices, elements or components. Those of ordinary skill in the art can understand the specific meaning of the above-mentioned terms in the present application according to the specific circumstances.

[0036] Furthermore, the terms "first," "second," etc., are primarily used to distinguish different devices, elements, or components (which may be the same or different in specific type and construction), and are not intended to indicate or imply the relative importance or quantity of the indicated devices, elements, or components. Unless otherwise stated, "a plurality of" means two or more.

[0037] Firstly, such as Figure 1 As shown, this application provides a method based on 226 Ra preparation 212 Pb's methods include:

[0038] S102, for containing 226 Ra target material is subjected to reactor irradiation treatment to obtain irradiated target material;

[0039] S104, dissolves the irradiated target material to obtain a target material solution;

[0040] S106, The target material solution is placed in the first separation column for the first acid elution treatment to obtain a Th-containing adsorption column. The first separation column is used to adsorb Th.

[0041] S108, the Th-containing adsorption column is subjected to a second acid elution to obtain a Th-containing eluent;

[0042] S110, the th-containing eluent was allowed to stand for a period of time to obtain... 228 Th standing liquid;

[0043] S112, containing 228 The Th settling solution was placed in the second separation column for a third acid elution treatment to obtain a solution containing... 212 The Pb eluent was used to separate lead in the second separation column.

[0044] In this embodiment, for containing 226 Ra target material is subjected to reactor irradiation treatment to obtain irradiated target material containing multiple nuclides. The irradiated target material is then separated and extracted to obtain... 212 Pb has the advantages of simple preparation process, high separation efficiency, high yield and low waste generation, which can effectively reduce the radiation dose of operators. The preparation method is suitable for medical scenarios and can achieve... 212 Large-scale preparation of Pb alleviates 212 The shortage of Pb supply is thus needed to address the needs of tumor treatment research. 212 The source of Pb medical isotopes.

[0045] In this application 212 The main principles of Pb preparation include:

[0046] 226Ra is generated by (n, γ) reaction during reactor irradiation treatment 227 Ra.

[0047] 227 Ra is generated by β decay 227 Ac, 227 Ac is generated by (n, γ) reaction 228 Ac. Alternatively, 227 Ra is generated by (n, γ) reaction 228 Ra, 228 Ra is generated by β decay 228 Ac.

[0048] 228 Ac is generated by β decay 228 Th.

[0049] 228 Th is generated by α decay 224 Ra.

[0050] 224 Ra is generated by 3 α decays 212 Pb.

[0051] In S102, the target material containing 226 Ra is subjected to reactor irradiation treatment, and after the irradiation target material, a plurality of nuclides are contained in the irradiation target material, for example, Th 228 , 227 Th, 226 Ra, 223 Ra, 224 Ra, 227 Ac, 228 Ac, and the like.

[0052] In S104, since the irradiation target material mainly contains various metals, in order to facilitate the separation and extraction of the nuclides, the irradiation target material is dissolved to obtain a target material solution.

[0053] In S106, mainly for extracting Th, the separation material filled in the first separation column is used to adsorb Th to form a Th-containing adsorption column, and other nuclides in the target material solution are eluted out.

[0054] Specifically, 228 Th, 227 Th is retained in the first separation column, that is, the Th-containing adsorption column adsorbs 228 Th, 227 Th.

[0055] 226 Ra, 223 Ra, 224 Ra, 227 Ac, and 228Ac and other nuclides are eluted, meaning that other nuclides remain in the eluent after the first acid washing treatment.

[0056] In S108, the Th nuclide is used to elute it from the Th-containing adsorption column, yielding a Th-containing eluent, which contains... 228 Th、 227 Th.

[0057] S110, due to 228 The half-life of Th compared to 227 Th has a longer half-life, therefore, when the Th-containing eluent is allowed to stand, the Th-containing eluent will contain more Th. 227 Th will become less and less, until finally only Th remains. 228 Th, that is, to obtain the content 228 Th standing liquid.

[0058] In S112, it will contain 228 The Th standing liquid is separated by a second separation column. 212 Pb separation: The material packed inside the second separation column is used for adsorption. 228 Th and its decay 224 Ra, non-adsorbent 212 Pb, during the rinsing process 228 Th and 224 Ra nuclide will remain in the second separation column. 212 Pb will be separated during the rinsing process.

[0059] The separation materials in the first separation column, used to separate Th from Ac and Ra, include ion exchange resins, extraction resins, COFs or MOFs, with a mesh size of 80-400 mesh. The separation materials in the second separation column, used to separate Pb from Th and Ra, also include ion exchange resins, extraction resins, COFs or MOFs, with a mesh size of 80-400 mesh.

[0060] In one specific embodiment, the preparation method includes: firstly, weighing 2g to 10g of separation material A and separation material B, and loading them into the first separation column and the second separation column respectively, and pre-washing them with 2 to 4 column volumes of sterile water for injection and the corresponding inorganic acid, adjusting the flow rate to 0.01mL / min to 1mL / min, and after pre-treatment, transferring them into a shielded box.

[0061] Using an inorganic acid of a certain concentration to treat the irradiated 226 Ra target material is rinsed into a round-bottom flask and dissolved at a specific heating temperature. The dissolved target material is then transferred to the first separation column using a power pump. The first separation column is eluted with 6–10 mol / L acid. Th( 228 Th、 227Th) was retained in the first separation column, while radium ( 226 Ra、 223 Ra、 224 Ra), Ac( 227 Ac、 228 Nuclide such as Ac was eluted, with a elution volume of approximately 20–70 mL.

[0062] Use 10–50 mL of 0.1–0.8 mol / L inorganic acid to separate Th(t) from the first separation column. 228 Th、 227 After elution, the sample is transferred to a temporary storage vial for storage. It can be removed by decay after 180–220 days. 228 Mixed in Th 227 Th, obtain pure 228 Th solution.

[0063] Through the pump 228 The Th solution was transferred to the second separation column. After standing for adsorption for a certain period of time, it was eluted with 0.8–1.2 mol / L acid, with a wash volume of less than 10 mL. 212 Pb was eluted to obtain pure Pb. 212 Pb products.

[0064] Finally, the second separation column can be eluted with acid of a specific concentration to recover the product. 228 Th.

[0065] In one possible implementation, S110, the Th-containing eluent is subjected to a standing treatment, specifically including: standing the Th-containing eluent for 150 days to 300 days.

[0066] In this embodiment, due to 228 The half-life of Th is 1.9 years, while 227 Th has a half-life of only 6.15 hours. By setting a reasonable settling time, it is possible to... 227 Th decays completely until it is completely removed, eventually forming a substance containing only Th. 228 Th's standing solution.

[0067] In one possible implementation, such as Figure 2 As shown, the method also includes: S114, performing a fourth acid elution on the second separation column after the third acid elution to obtain a Th-containing recovery solution.

[0068] In this embodiment, after the third acid elution treatment, the second separation column contains adsorbed... 228 Th and its decay 224 Ra, and then by performing a fourth acid elution on the second separation column, can be obtained 228 Th is effectively recycled.

[0069] In one possible implementation, the acid concentration in the fourth acid rinsing process is different from the acid concentration in the third acid rinsing process.

[0070] In one possible implementation, containing 226 Ra targets include one of the following: radium nitrate, radium chloride, radium carbonate, radium sulfate, and radium bromide.

[0071] What one can think of is, containing 226 Ra targets can contain... 226 Inorganic salts of Ra.

[0072] In one possible implementation, the dissolution process uses one of nitric acid, hydrochloric acid, and hydrofluoric acid, with an acid concentration of 1 mol / L to 4 mol / L.

[0073] Hydrochloric acid and nitric acid are preferred for the dissolution process.

[0074] In one possible implementation, the first acid rinsing treatment, the second acid rinsing treatment, the third acid rinsing treatment, and the fourth acid rinsing treatment are performed using inorganic acids, such as nitric acid or hydrochloric acid.

[0075] It should be noted that hydrochloric acid is preferred in any acid rinsing process. Hydrochloric acid includes medical-grade hydrochloric acid; the solution preparation conditions should be suitable for a medical-grade hydrochloric acid system, thus facilitating… 212 Subsequent use of PbCl2 solution.

[0076] In one possible implementation, when the adsorption material of the Th-containing adsorption column is an ion exchange resin, the acid concentration in the second acid rinsing treatment is 6 mol / L to 11.0 mol / L.

[0077] In one possible implementation, when the adsorbent material of the Th-containing adsorption column is an extraction resin, the acid concentration in the second acid rinsing treatment is 0.01 mol / L to 1 mol / L.

[0078] In one possible implementation, the acid concentration in the third acid rinsing treatment is 0.01 mol / L to 2 mol / L.

[0079] In one possible implementation, the acid concentration in the fourth acid rinsing treatment is 0.5 mol / L to 1.5 mol / L.

[0080] In one possible implementation, the rinsing flow rate in the first acid rinsing treatment, the second acid rinsing treatment, the third acid rinsing treatment, and the fourth acid rinsing treatment is 0.01 mL / min to 5 mL / min.

[0081] Secondly, this application provides a method based on 226 Ra preparation212 A device for treating Pb, used in implementing any of the methods described above, includes a shielding box, a target dissolution assembly, a first separation column, a second separation column, and a solution bottle. The target dissolution assembly is located inside the shielding box and is used to contain and dissolve the irradiated target. The inlet end of the first separation column is connected to the target dissolution assembly, and the first separation column is used to adsorb Th. The second separation column is connected to the outlet end of the first separation column and is used to separate lead. The solution bottle is connected to the outlet end of the second separation column and is used to collect Pb-containing solutions. 212 Pb eluent.

[0082] The apparatus provided in this application includes a shielding box, a target dissolution assembly, a first separation column, a second separation column, and a solution bottle. 226 After the Ra target material completes reactor irradiation treatment, the irradiated target material is dissolved in the target dissolution assembly.

[0083] After the irradiated target material is dissolved, the target material solution is transported to the inlet of the first separation column. The target material solution reacts in the first separation column, and the Th nuclides in the target material solution are adsorbed onto the separation material in the first separation column.

[0084] Next, the Th nuclides adsorbed on the first separation column are subjected to a second acid elution to obtain a Th-containing eluent. This Th-containing eluent is then allowed to stand to obtain a solution containing... 228 Th standing liquid.

[0085] Then, add the 228 The th settling solution is transferred to the second separation column, where it undergoes further processing. 212 Pb separation, 212 Pb was eluted and ultimately retained in the solution bottle.

[0086] In a specific embodiment, such as Figure 3 As shown, the device provided in this application includes multiple solution bottles, multiple power pumps, multiple multi-way valves, a flask 6, a first separation column 9, a second separation column 15, a heating plate 21, and a shielding box 22.

[0087] The system includes multiple solution bottles, namely, solution bottle 1, solution bottle 2, solution bottle 5, solution bottle 11, solution bottle 13, solution bottle 17, solution bottle 18, and solution bottle 20. It is worth noting that these solution bottles can store solutions and are made of quartz glass, which is heat-resistant and corrosion-resistant. They are graduated, some are located outside the shielded working chamber, and their capacities range from 10mL to 2L.

[0088] Among them, multiple power pumps include a first power pump 4, a second power pump 7, a third power pump 12, and a fourth power pump 19.

[0089] Among them, the multiple multi-way valves include the first multi-way valve 3, the second multi-way valve 8, the third multi-way valve 10, the fourth multi-way valve 14, and the fifth multi-way valve 16.

[0090] It should be noted that the power pump can be a peristaltic pump, syringe pump, constant flow pump, etc., which can precisely control the volume and flow rate of the required solution and inject it into the system.

[0091] The separation column is filled with a specific separation material, which can be PEK or quartz glass, and is corrosion resistant. The upper and lower ends of the separation column are connected to pipelines through quick-connect interfaces, which can achieve the retention and elution of different nuclides.

[0092] The device includes a multi-way valve that can be easily operated by a robotic arm. The valve can be turned to control the flow of the solution and direct it to different branches.

[0093] The shielding box is used to shield the radiation dose during operation. It measures 2*1.5*1.5m and is mainly composed of lead, lead glass, and stainless steel.

[0094] The specific preparation process is as follows:

[0095] After transferring the irradiated target material to flask 6, the first power pump 4 is turned on to add the solution from the third solution bottle 5, and the heating plate 6 is turned on to dissolve the irradiated target material, thus obtaining the target material solution.

[0096] The target material solution is transferred to the first separation column 9 by the second power pump 7 and the second multi-way valve 8, and then allowed to stand for adsorption.

[0097] Open the first power pump 4, the first multi-way valve 3, and the second multi-way valve 8. Use the solution in the first solution bottle 1 to rinse the first separation column 9. Adjust the third multi-way valve 10 to collect the eluent (containing radium, Ac, and other nuclides) into the fourth solution bottle 11. Open the first power pump 4, the first multi-way valve 3, and the second multi-way valve 8. Use the solution in the second solution bottle 2 to rinse the first separation column 9. Adjust the third multi-way valve 10 to collect the eluent (containing Th nuclides) into the fifth solution bottle 13. After standing for 180 days, open the third power pump 12 and the fourth multi-way valve 14. Transfer the solution in the fifth solution bottle 13 to the second separation column 15 and allow it to stand for adsorption. Open the fourth power pump 19, adjust the fourth multi-way valve 14 and the fifth multi-way valve 16, and use the solution in the eighth solution bottle 20 to rinse the second separation column 15 to obtain... 212 Pb solution. If recovery is required after a period of time. 228 Th, replace the solution in the solution bottle with an acid of a different concentration, turn on the fourth power pump 19, and adjust the fifth multi-way valve 16 to... 228 Th is recovered into the seventh solution bottle 18.

[0098] Example 1

[0099] Weigh 2g of Dowex 1X8 anion exchange resin and pack it into the first separation column 9. Then, pretreat the first separation column 9 by washing it with 30mL of sterile water for injection and 30mL of 8.0mol / L hydrochloric acid.

[0100] Weigh 2g of Dowex 50WX8 cation exchange resin and pack it into the second separation column 15. Pre-treat the second separation column 15 by washing it with 30mL of sterile water for injection and 30mL of 1.0mol / L hydrochloric acid in sequence, and then pack it into the shielded box 22.

[0101] Example 2

[0102] 44.6 mg of radium nitrate after being irradiated by the reactor ( 226 The Ra(NO3)2) target material was transferred to flask 6, and 10 mL of 2M hydrochloric acid was added. The temperature of the heating plate was adjusted to allow the solution to gently boil. After 30 minutes, the target material was completely dissolved, and the solution became clear and transparent. The syringe pump was turned on, and the target material solution was transferred to separation column 9. The solution was allowed to stand for 40 minutes to allow for complete adsorption. The separation column was eluted with 50 mL of 8M hydrochloric acid, and the eluent containing Ac and Ra was collected into a solution bottle. The separation column 9 was then eluted with 50 mL of 0.8M hydrochloric acid, and the solution containing Th was collected into a solution bottle. After 180 days, 227 Th decays completely, yielding pure th. 228 Th solution.

[0103] Example 3

[0104] In Example 2 228 The Th solution was added to separation column 15 and allowed to stand for 1 hour to allow complete adsorption. The column was then eluted with 20 mL of 0.9 M hydrochloric acid to obtain pure Th solution. 212 PbCl2 solution, elution efficiency greater than 95%, nuclear purity greater than 99.5%; after standing for 3 days, wait... 212 Pb continued to grow, and the separation column was washed with 20 mL of 0.9 M hydrochloric acid for 15 minutes to obtain... 212 PbCl2 solution. After rinsing for a period of time, it can be treated with 9M hydrochloric acid. 228 The recovery rate is greater than 80%.

[0105] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. A method based on 226 Ra preparation 212 The method of Pb is characterized by, include: For containing 226 Ra target material is subjected to reactor irradiation treatment to obtain irradiated target material; The irradiated target is dissolved to obtain a target solution; The target material solution is placed in the first separation column and subjected to the first acid elution treatment to obtain a Th-containing adsorption column. The first separation column is used to adsorb Th. The Th-containing adsorption column was subjected to a second acid elution to obtain a Th-containing eluent. The Th-containing eluent was allowed to stand to obtain a solution containing Th. 228 Th standing liquid; The containing 228 The Th settling solution was placed in the second separation column for a third acid elution treatment to obtain a solution containing... 212 Pb eluent, the second separation column is used to separate lead.

2. The method according to claim 1, characterized in that, The step of allowing the Th-containing eluent to stand for a period of time specifically includes: The Th-containing eluent was allowed to stand for 150 to 300 days.

3. The method according to claim 1, characterized in that, The method further includes: The second separation column, after the third acid elution treatment, is subjected to a fourth acid elution treatment to obtain a Th-containing recovery solution.

4. The method according to claim 3, characterized in that, The acid concentration in the fourth acid rinsing treatment is different from the acid concentration in the third acid rinsing treatment.

5. The method according to claim 1, characterized in that, The containing 226 Ra targets include one of the following: radium nitrate, radium chloride, radium carbonate, radium sulfate, and radium bromide.

6. The method according to claim 1, characterized in that, The dissolution process uses one of nitric acid, hydrochloric acid, and hydrofluoric acid, and the acid concentration in the dissolution process is 1 mol / L to 4 mol / L.

7. The method according to claim 4, characterized in that, The first acid rinsing treatment, the second acid rinsing treatment, the third acid rinsing treatment and the fourth acid rinsing treatment are performed using inorganic acids, namely nitric acid or hydrochloric acid.

8. The method according to claim 7, characterized in that, When the adsorption material of the Th-containing adsorption column is an ion exchange resin, the acid concentration in the second acid rinsing treatment is 6 mol / L to 11.0 mol / L; When the adsorption material of the Th-containing adsorption column is an extraction resin, the acid concentration in the second acid rinsing treatment is 0.01 mol / L to 1 mol / L.

9. The method according to claim 7, characterized in that, The acid concentration in the third acid rinsing treatment is 0.01 mol / L to 2 mol / L; The acid concentration in the fourth acid rinsing treatment is 0.5 mol / L to 1.5 mol / L; The rinsing flow rate in the first acid rinsing treatment, the second acid rinsing treatment, the third acid rinsing treatment, and the fourth acid rinsing treatment is 0.01 mL / min to 5 mL / min.

10. A method based on 226 Ra preparation 212 The device of Pb, used for carrying out the method according to any one of claims 1 to 9, is characterized in that, The device includes: Shielding box; The target dissolution assembly, located inside the shielding box, is used to contain and dissolve the irradiated target material; A first separation column, the inlet end of which is connected to the target material dissolution assembly, is used to adsorb Th; The second separation column is connected to the outlet end of the first separation column, and the second separation column is used to separate lead; A solution bottle, connected to the outlet end of the second separation column, is used to collect solutions containing... 212 Pb eluent.

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